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Percentile preterm infant

Kathryn J Sharma, Tania F Esakoff, Alyson Guillet, Richard M Burwick, Aaron B Caughey
OBJECTIVE: To determine whether adverse outcomes were more common in late preterm pregnancies complicated by preeclampsia and growth restriction compared to those affected by preeclampsia alone. METHODS: This was a retrospective cohort study of 8,927 singleton pregnancies with preeclampsia. Pregnancies with small for gestational age (SGA) neonates (birthweight <10(th) percentile) were compared to those appropriate for gestational age (AGA) neonates. Maternal outcomes included cesarean delivery (CD) rate, CD for fetal heart rate (FHR) abnormalities, abruption, postpartum hemorrhage (PPH), maternal transfusion, acute renal failure, and peripartum cardiomyopathy...
October 19, 2016: Journal of Maternal-fetal & Neonatal Medicine
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Nelly Padilla, Peter Fransson, Antonio Donaire, Francesc Figueras, Angela Arranz, Magdalena Sanz-Cortés, Violeta Tenorio, Núria Bargallo, Carme Junqué, Hugo Lagercrantz, Ulrika Ådén, Eduard Gratacós
Fetal growth restriction (FGR) affects brain development in preterm infants, but little is known about its effects on resting-state functional connectivity. We compared 20 preterm infants, born at <34 weeks of gestation with abnormal antenatal Doppler measurements and birth weights <10th percentile, with 20 appropriate for gestational age preterm infants of similar gestational age and 20 term infants. They were scanned without sedation at 12 months of age and screened for autistic traits at 26 months...
September 6, 2016: Cerebral Cortex
Michael W Rankin, Elizabeth Yakes Jimenez, Marina Caraco, Marie Collinson, Lisa Lostetter, Tara L DuPont
OBJECTIVE: To evaluate the accuracy of pre- and postfeeding weights to estimate enteral feeding volumes in preterm infants. STUDY DESIGN: Single-center prospective cohort study of infants 28-36 weeks' corrected age receiving gavage feedings. For each test weight, 3 pre- and 3 postgavage feeding weights were obtained by study personnel, blinded to feeding volume, via a specific protocol. The correlation between test weight difference and actual volume ingested was assessed by the use of summary statistics, Spearman rho, and graphical analyses...
August 29, 2016: Journal of Pediatrics
Eun Jin Kwon, Hye Ah Lee, Young-Ah You, Hyesook Park, Su Jin Cho, Eun Hee Ha, Young Ju Kim
The association of preterm birth with obesity and metabolic syndrome later in life is well established. Although the biological mechanism for this association is poorly understood, epigenetic alterations of metabolic-related genes in early life may have important roles in metabolic dysfunction. Thus, we investigated the associations of DNA methylations of melanocortin 4 receptor (MC4R) and hepatocyte nuclear factor 4 alpha (HNF4α) with metabolic profiles in cord blood of term and preterm infants.We measured metabolic profiles in cord blood samples of 85 term and 85 preterm infants...
August 2016: Medicine (Baltimore)
Sabine Huenecke, Esther Fryns, Boris Wittekindt, Horst Buxmann, Christoph Königs, Andrea Quaiser, Doris Fischer, Melanie Bremm, Thomas Klingebiel, Ulrike Koehl, Rolf Schloesser, Konrad Bochennek
Preterm newborns show an increased susceptibility to infections, conceivably related to their immature immune system. To gain further knowledge about the immune development in early preterm infants, we aimed to establish references for lymphocyte subsets and compare the maturation process during hospitalization to healthy term-born children and adolescents. For this purpose peripheral blood samples (n=153) were collected from 40 preterm infants; gestational age (GA) 26 to 30 week between 2(nd) and 6(th) day of life and were monitored in intervals of every 2 or rather 4 weeks until the end of hospitalization...
August 22, 2016: Scandinavian Journal of Immunology
Eisha Christian, Thomas Imahiyerobo, Alexis Johns, Pedro Sanchez, Mark D Krieger, J Gordon McComb, Mark Urata
INTRODUCTION: Patients with nonsyndromic sagittal craniosynostosis (SC) were previously thought to have normal neurocognitive development; however, a pattern of mild delays has been described in these patients. We reviewed our patients with SC to identify potential perinatal risk factors that serve as indicators for subsequent developmental delay. METHODS: Nonsyndromic patients with SC (n = 66) completed preoperative Bayley Scales of Infant and Toddler Development (III) with a single examiner between August 2009 and April 2015...
August 2016: Neurosurgery
Serdar Umit Sarici, Omer Gunes, Esad Koklu, Muhittin A Serdar
OBJECTIVE: We aimed to develop a transcutaneous bilirubin (TcB) nomogram for assessment of the risk of significant hyperbilirubinemia and prolonged jaundice during the first month of life in term and late-preterm Turkish newborns. METHODS: On the basis of the daily (3rd, 7th, 15th and 30th days) TcB measurements, 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentiles, and 5 percentile tracks were obtained. TcB measurements were made by a transcutaneous bilirubinometer (JaundiceDetector JH20-1C)...
July 7, 2016: Journal of Tropical Pediatrics
Sarah K Dotters-Katz, Whitney M Humphrey, Kayli L Senz, Vanessa R Lee, Brian L Shaffer, Aaron B Caughey
Objective This study aims to evaluate the perinatal and neonatal outcomes associated with prenatal diagnosis of 45,X, both with and without fetal cardiac anomalies. Study Design A retrospective cohort of singleton pregnancies in California, 2005 to 2008, using vital statistics and International Classification of Diseases, Ninth Revision data, identifying prenatally diagnosed 45,X. Outcomes included preterm delivery, preeclampsia, intrauterine fetal demise (IUFD), cesarean section, small for gestational age (SGA), neonatal death, and infant death...
October 2016: American Journal of Perinatology
Jun Sasahara, Keisuke Ishii, Nagayoshi Umehara, Mari Oba, Kenji Kiyoshi, Takeshi Murakoshi, Tomohiro Tanemoto, Hiroshi Ishikawa, Kiyotake Ichizuka, Aya Yoshida, Kei Tanaka, Katsusuke Ozawa, Haruhiko Sago
AIM: The aim of this study was to evaluate the association between oligohydramnios and other perinatal factors in preterm small-for-gestational-age (SGA) infants who had cerebral palsy at 18 months of age or who had died before this age. METHODS: This retrospective study included 320 infants with birthweights < 3rd percentile delivered between 22 and 33 complete weeks of gestation. We evaluated the incidence of CP at 18 months of age and of death before this age...
June 29, 2016: Journal of Obstetrics and Gynaecology Research
Cristina T Navarrete, Lisa A Wrage, Waldemar A Carlo, Michele C Walsh, Wade Rich, Marie G Gantz, Abhik Das, Kurt Schibler, Nancy S Newman, Anthony J Piazza, Brenda B Poindexter, Seetha Shankaran, Pablo J Sánchez, Brenda H Morris, Ivan D Frantz, Krisa P Van Meurs, C Michael Cotten, Richard A Ehrenkranz, Edward F Bell, Kristi L Watterberg, Rosemary D Higgins, Shahnaz Duara
OBJECTIVE: To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. STUDY DESIGN: We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges...
September 2016: Journal of Pediatrics
Jamie L Morgan, David B Nelson, Scott W Roberts, C Edward Wells, Donald D McIntire, F Gary Cunningham
Objective To examine blood pressure patterns across pregnancy in women with treated chronic hypertension according to the occurrence of severe preeclampsia, growth restriction, and preterm birth <34 weeks. Methods This retrospective descriptive case study included only pregnant women receiving antihypertensive therapy. Using a random effects model, mean arterial pressures were plotted across gestation for women with and without preeclampsia, fetal growth restriction, and preterm birth <34 weeks with differences analyzed for each curve...
October 2016: American Journal of Perinatology
Mabel Berrueta, Jennifer Hemingway-Foday, Vanessa R Thorsten, Robert L Goldenberg, Waldemar A Carlo, Ana Garces, Archana Patel, Sarah Saleem, Omrana Pasha, Elwyn Chomba, Patricia L Hibberd, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Fabian Esamai, Edward A Liechty, Janet L Moore, Elizabeth M McClure, Marion Koso-Thomas, Pierre M Buekens, José M Belizán, Fernando Althabe
BACKGROUND: Antenatal corticosteroids (ACS) for women at high risk of preterm birth is an effective intervention to reduce neonatal mortality among preterm babies delivered in hospital settings, but has not been widely used in low-middle resource settings. We sought to assess the rates of ACS use at all levels of health care in low and middle income countries (LMIC). METHODS: We assessed rates of ACS in 7 sites in 6 LMIC participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Global Network for Women and Children's Health Research Antenatal Corticosteroids Trial (ACT), a cluster-randomized trial to assess the feasibility, effectiveness, and safety of a multifaceted intervention designed to increase the use of ACS...
2016: Reproductive Health
Ju Lee Oei, Alpana Ghadge, Elisabeth Coates, Ian M Wright, Ola D Saugstad, Maximo Vento, Giuseppe Buonocore, Tatsuo Nagashima, Keiji Suzuki, Shiguhero Hosono, Peter G Davis, Paul Craven, Lisa Askie, Jennifer Dawson, Shalabh Garg, Anthony Keech, Yacov Rabi, John Smyth, Sunil Sinha, Ben Stenson, Kei Lui, Carol Lu Hunter, William Tarnow Mordi
AIM: This study determined current international clinical practice and opinions regarding initial fractional inspired oxygen (FiO2 ) and pulse oximetry (SpO2 ) targets for delivery room resuscitation of preterm infants of less than 29 weeks of gestation. METHODS: An online survey was disseminated to neonatal clinicians via established professional clinical networks using a web-based survey programme between March 9 and June 30, 2015. RESULTS: Of the 630 responses from 25 countries, 60% were from neonatologists...
September 2016: Acta Paediatrica
Steven Caskey, Aisling Gough, Stephen Rowan, Scott Gillespie, Jim Clarke, Marshall Riley, Jacqui Megarry, Paul Nicholls, Chris Patterson, Henry L Halliday, Michael D Shields, Lorcan McGarvey
RATIONALE: As more preterm infants recover from severe bronchopulmonary dysplasia (BPD), it is critical to understand the clinical consequences of this condition on the lung health of adult survivors. OBJECTIVES: To assess structural and functional lung parameters in young adult BPD survivors and preterm and term control subjects. METHODS: Young adult survivors of BPD (mean age, 24 yr) underwent spirometry, lung volume assessment, transfer factor, lung clearance index, and fractional exhaled nitric oxide measurements, together with high-resolution chest computed tomography and cardiopulmonary exercise testing...
August 2016: Annals of the American Thoracic Society
Elizabeth M McClure, Robert L Goldenberg, Alan H Jobe, Menachem Miodovnik, Marion Koso-Thomas, Pierre Buekens, Jose Belizan, Fernando Althabe
The Global Network's Antenatal Corticosteroids Trial (ACT), was a multi-country, cluster-randomized trial to improve appropriate use of antenatal corticosteroids (ACS) in low-resource settings in low-middle income countries (LMIC). ACT substantially increased ACS use in the intervention clusters, but the intervention failed to show benefit in the targeted < 5th percentile birth weight infants and was associated with increased neonatal mortality and stillbirth in the overall population. In this issue are six papers which are secondary analyses related to ACT that explore potential reasons for the increase in adverse outcomes overall, as well as site differences in outcomes...
2016: Reproductive Health
Karen Klein, Elizabeth M McClure, Daniela Colaci, Vanessa Thorsten, Patricia L Hibberd, Fabian Esamai, Ana Garces, Archana Patel, Sarah Saleem, Omrana Pasha, Elwyn Chomba, Waldemar A Carlo, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Edward A Liechty, Marion Koso-Thomas, Pierre M Buekens, José M Belizán, Robert L Goldenberg, Fernando Althabe
BACKGROUND: The Antenatal Corticosteroid Trial (ACT) assessed the feasibility, effectiveness, and safety of a multifaceted intervention to increase the use of antenatal corticosteroids (ACS) in mothers at risk of preterm birth at all levels of care in low and middle-income countries. The intervention effectively increased the use of ACS but had no overall impact on neonatal mortality in the targeted <5(th) percentile birth weight infants. Being in the intervention clusters was also associated with an overall increase in neonatal deaths...
2016: Reproductive Health
Ana Garces, Elizabeth M McClure, Lester Figueroa, Sayury Pineda, K Michael Hambidge, Nancy F Krebs, Vanessa R Thorsten, Dennis D Wallace, Fernando Althabe, Robert L Goldenberg
BACKGROUND: The Global Network for Women's and Children's Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala's improvement in neonatal mortality was by far the largest...
2016: Reproductive Health
Fernando Althabe, Vanessa Thorsten, Karen Klein, Elizabeth M McClure, Patricia L Hibberd, Robert L Goldenberg, Waldemar A Carlo, Ana Garces, Archana Patel, Omrana Pasha, Elwyn Chomba, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Fabian Esamai, Edward A Liechty, Nellie I Hansen, Sreelatha Meleth, Dennis D Wallace, Marion Koso-Thomas, Alan H Jobe, Pierre M Buekens, José M Belizán
BACKGROUND: The Antenatal Corticosteroid Trial assessed the feasibility, effectiveness, and safety of a multifaceted intervention to increase the use of antenatal corticosteroids (ACS) in mothers at risk of preterm birth at all levels of care in low and middle-income countries. The intervention effectively increased the use of ACS but was associated with an overall increase in neonatal deaths. We aimed to explore plausible pathways through which this intervention increased neonatal mortality...
2016: Reproductive Health
Alfa Muhihi, Christopher R Sudfeld, Emily R Smith, Ramadhani A Noor, Salum Mshamu, Christina Briegleb, Mohamed Bakari, Honorati Masanja, Wafaie Fawzi, Grace Jean-Yee Chan
BACKGROUND: Few studies have differentiated risk factors for term-small for gestational age (SGA), preterm-appropriate for gestational age (AGA), and preterm-SGA, despite evidence of varying risk of child mortality and poor developmental outcomes. METHODS: We analyzed birth outcome data from singleton infants, who were enrolled in a large randomized, double-blind, placebo-controlled trial of neonatal vitamin A supplementation conducted in Tanzania. SGA was defined as birth weight <10th percentile for gestation age and sex using INTERGROWTH standards and preterm birth as delivery at <37 complete weeks of gestation...
2016: BMC Pregnancy and Childbirth
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