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https://www.readbyqxmd.com/read/29145040/pornography-headache
#1
Wei-Hsi Chen, Kuo Yen Chen, Hsin-Ling Yin
The headache associated with intercourse or masturbatory activity is a well-recognized clinical entity but pornography headache is barely mentioned. We report a young man who suffered preorgasmic headache pertaining only to pornography of specific erotic contents but not to other sexual or nonsexual act. An antecedent activation of sexual arousal and vasoconstriction during pain were found. Finally, oral indomethacin favorably prevented the pain. Therefore, pornography headache is a distinguished headache disorder distinct from other sexual-related headache disorders...
November 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29140411/effect-of-angiotensin-ii-and-acth-on-adrenal-blood-flow-in-the-male-rat-adrenal-gland-in-vivo
#2
Abdul J Shah, Tamas Kriska, Kathryn M Gauthier, John R Falck, William B Campbell
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and/or zona glomeulosa cell-derived mediators. The role of these mediators in regulating adrenal blood flow (ABF) and mean arterial pressure (MAP) was examined in anesthetized rats. Ang II (0.01-100 ng/kg) increased ABF (maximal increase of 97.2 ± 6.9 perfusion units (PU) at 100 ng/kg) and MAP (basal, 115 ± 7 mm Hg; Ang II, 163 ± 5 mm Hg). ACTH (0.1-1000 ng/kg) also increased ABF (maximum increase of 91...
November 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29137170/design-synthesis-and-biological-activity-of-tetrahydrobenzo-4-5-thieno-2-3-d-pyrimidine-derivatives-as-anti-inflammatory-agents
#3
Yuan Zhang, Lu Luo, Chao Han, Handeng Lv, Di Chen, Guoliang Shen, Kaiqi Wu, Suwei Pan, Faqing Ye
We designed and synthesized 26 prototype compounds and studied their anti-inflammatory activity and underlying molecular mechanisms. The inhibitory effects of the compounds on the production of nitric oxide (NO), cytokines, inflammatory-related proteins, and mRNAs in lipopolysaccharide (LPS)-stimulated macrophages were determined by the Griess assay, Enzyme linked immunosorbent assay (ELISA), Western blot analysis, and Reverse transcription-Polymerase Chain Reaction (RT-PCR), respectively. Our results indicated that treatment with A2, A6 and B7 significantly inhibited the secretion of NO and inflammatory cytokines in RAW264...
November 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29136948/gastroprotective-effect-and-mode-of-action-of-methanol-extract-of-sphenodesme-involucrata-var-paniculata-c-b-clarke-munir-lamiaceae-leaves-on-experimental-gastric-ulcer-models
#4
Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, Sathyanarayanan Saikumar, Muniyandi Kasipandi, Sivaraj Dhivya, Rajan Murugan, Thangaraj Parimelazhagan
Sphenodesme involucrata var. paniculata (C. B. Clarke) Munir, endemic to South Asia, is used by tribal for alleviation from abdominal disorders, inflammation and body pain. However, the gastroprotective properties of this species have not yet been studied. The leaves of S. involucrata were extracted by Soxhlet extraction using different solvents successively and the extracts were analyzed for antioxidant and anti-Helicobacter pylori activities using different in vitro assays. The chemical composition of methanol extract of S...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136777/anti-hypertensive-and-vasodilatory-effects-of-amended-banxia-baizhu-tianma-tang
#5
Chu Shan Tan, Yean Chun Loh, Chiew Hoong Ng, Yung Sing Ch'ng, Mohd Zaini Asmawi, Mariam Ahmad, Mun Fei Yam
Although Banxia Baizhu Tianma Tang (BBT) has been long administered for hypertensive treatment in Traditional Chinese Medicine (TCM), the ratio of the herbal components that makes up the formulation has not been optimized with respect to the anti-hypertensive effect that it inherently possesses. A newly amended BBT (ABBT) formulation was developed using the evidence-based approach of orthogonal stimulus-response compatibility model. The ABBT showed enhanced therapeutic effect while maintaining its traditional theoretical approach rooted in TCM...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29134814/direct-uv-triggered-thiol-ene-cross-linking-of-electrospun-polyester-fibers-from-unsaturated-poly-macrolactone-s-and-their-drug-loading-by-solvent-swelling
#6
Fernando C S de Oliveira, Dinorath Olvera, Michael J Sawkins, Sally-Ann Cryan, Scott D Kimmins, Tatiane Eufrasio da Silva, Daniel J Kelly, Garry P Duffy, Cathal Kearney, Andreas Heise
Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 μm is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology...
November 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29128794/baicalin-protects-against-gastroduodenal-ulcers-via-the-modulation-of-nrf2-expression-experimental-biochemical-and-histological-analyses
#7
Tao Zhang, Dong Yang, Xiangyu Meng
BACKGROUND: The present study aimed to determine the mechanisms underlying the gastroprotective effects of baicalin using several animal models of chemically induced gastric ulcers. METHODS: The gastroprotective effects of baicalin against ulcers induced by water immersion stress, alcohol-induced ligation, and indomethacin-induced pylorus ligation were assessed in the present study. Additionally, macroscopic evaluations were performed at the completion of the study and Western blot analyses of Nrf2 were conducted to determine the possible mechanisms of action underlying the effects of baicalin...
July 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128789/diuretic-and-natriuretic-effect-of-luteolin-in-normotensive-and-hypertensive-rats-role-of-muscarinic-acetylcholine-receptors
#8
Thaise Boeing, Luísa Mota da Silva, Marihá Mariott, Sérgio Faloni de Andrade, Priscila de Souza
BACKGROUND: Luteolin is a very common phenolic compound found in a wide variety of natural products. Although several biological properties have already been described regarding the beneficial effect of luteolin in the cardiovascular and renal system, no scientific research explored its potential effect as a diuretic agent in experimental trials. METHODS: Groups of male normotensive (NTR) and spontaneously hypertensive rats (SHR) were orally treated with vehicle, hydrochlorothiazide or luteolin...
May 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127031/sulfur-mustard-induced-mast-cell-degranulation-in-mouse-skin-is-inhibited-by-a-novel-anti-inflammatory-and-anticholinergic-bifunctional-prodrug
#9
Laurie B Joseph, Gabriella M Composto, Roberto M Perez, Hong-Duck Kim, Robert P Casillas, Ned D Heindel, Sherri C Young, Carl J Lacey, Jaya Saxena, Christophe D Guillon, Claire R Croutch, Jeffrey D Laskin, Diane E Heck
Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated the role of mast cells in SM-induced skin injury using a murine vapor cup exposure model. Mast cells, identified by toluidine blue staining, were localized in the dermis, adjacent to dermal appendages and at the dermal/epidermal junction...
November 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29126792/in-vivo-cellular-and-molecular-gastroprotective-mechanisms-of-chrysin-emphasis-on-oxidative-stress-inflammation-and-angiogenesis
#10
Mina Y George, Ahmed Esmat, Mariane G Tadros, Ebtehal El-Demerdash
Gastric ulcer is one of the major gastrointestinal disorders affecting people worldwide. Despite medical advances, management of gastric ulcer and its complications remains a challenge facing medicine nowadays. In addition, currently available medicines exhibit limited efficacy and several side effects. In the current study, the potential protective effects of chrysin -naturally occurring flavonoid- were tested against indomethacin-induced gastric ulcer model in rats. It was found that chrysin in both doses; 50 and 100mg/kg were effective in promoting mucus secretion and preventing the rise in ulcer and lesion indices, acid production and histologic changes induced by indomethacin...
November 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29125764/selective-acceleration-of-crystal-growth-of-indomethacin-polymorphs-by-low-concentration-poly-ethylene-oxide
#11
Qin Shi, Jie Zhang, Chen Zhang, Jing Jiang, Jun Tao, Dongshan Zhou, Ting Cai
Physical stability of pharmaceutical amorphous solid dispersions is one of the critical attributes to the successful development of the formulation. Herein, we studied the impact of low-concentration poly(ethylene oxide) (PEO) on the crystallization rates of three polymorphs of indomethacin (IMC, γ, α and δ-form). We observed that the addition of 3% w/w PEO significantly increased the crystal growth rates of γ-form and α-from of IMC, but had a negligible effect on the δ-form. The reduction of the activation energy for the crystal growth of IMC polymorphs after adding the PEO follows the order γ-form > α-form > δ-form, which is consistent with the trend toward the accelerating effects of PEO on the crystal growth rates of three polymorphs...
November 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29123442/functional-effects-of-alagebrium-alt-711-isolated-rat-carotid-artery
#12
Cigdem Toprak, Basar Sirmagul, Semra Yigitaslan
Objective: In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings. Materials and Methods: To clarify the vasodilator mechanism of alagebrium, different antagonists such as N(G)-Nitro-L-arginine methyl ester (L-NAME), glibenclamide, indomethacin, metoprolol, propranolol, tetraethylammonium, and calcium channel activator BAYK-8644 were used to reverse this effect...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29120271/apple-polyphenol-suppresses-indomethacin-induced-gastric-damage-in-experimental-animals-by-lowering-oxidative-stress-status-and-modulating-the-mapk-signaling-pathway
#13
Yi-Chen Lee, Chun-Wen Cheng, Huei-Jane Lee, Huei-Chuien Chu
Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades...
November 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29113822/lack-of-tnf-%C3%AE-signaling-through-p55-makes-the-mice-more-susceptible-to-acute-infection-but-does-not-alter-state-of-latency-and-reactivation-of-hsv-1
#14
Aditi Mohankrishnan, Rajesh Parmar, Vishakha Bhurani, Sarat Kumar Dalai
TNF-α has been shown to play an important role in pathogenesis and latency of HSV-1 infections. TNF-α signals through TNFR1 (p55) and TNFR2 (p75), and signaling through p55 generally results in gene activation leading to induction of inflammatory responses. Here, we studied the role of TNF-α signaling in latent virus reactivation in p55-knock out (KO) mouse model of ocular HSV-1 infection. We found that KO mice are more susceptible to HSV-1 infection compared to wild type C57Bl/6 mice. While the absence of TNFRI signaling enhanced the ganglion latent DNA content by two folds, there was no difference in the maintenance and reactivation of latent HSV-1...
November 4, 2017: Virus Research
https://www.readbyqxmd.com/read/29111765/nanostructures-and-dynamics-of-isochorically-confined-amorphous-drug-mediated-by-cooling-rate-interfacial-and-intermolecular-interactions
#15
Chen Zhang, Ye Sha, Yue Zhang, Ting Cai, Linling Li, Dongshan Zhou, Xiaoliang Wang, Gi Xue
The production and stabilization of amorphous drugs by the nanoconfinement effect has recently become a research hotspot in pharmaceutical sciences. Herein, two guest/host systems-indomethacin (IMC) and griseofulvin (GSF)-confined in anodic aluminum oxide (AAO) templates with different pore diameters (25-250 nm) are investigated by differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS). The crystallization of the confined drugs is suppressed, and their glass transition temperatures show an evident pore-size dependency...
November 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29107615/the-natural-bile-acid-surfactant-sodium-taurocholate-natc-as-a-coformer-in-coamorphous-systems-enhanced-physical-stability-and-dissolution-behavior-of-coamorphous-drug-natc-systems
#16
Katarzyna Gniado, Pól MacFhionnghaile, Patrick McArdle, Andrea Erxleben
The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or after cryomilling and 14 of the 18 coamorphous drug-NaTC systems were physically stable for between one to eleven months under ambient storage conditions. In three cases, namely carbamazepine-NaTC, indomethacin-NaTC and mefenamic acid-NaTC, significant dissolution advantages over the crystalline drugs were observed, both for the freshly prepared samples and after storage for seven months...
October 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29104249/carrageenans-sulfated-polysaccharides-from-red-seaweeds-as-matrices-for-the-inclusion-of-echinochrome
#17
Irina M Yermak, Natalia P Mischchenko, Viktoria N Davydova, Valery P Glazunov, Daria V Tarbeeva, Anna O Kravchenko, Evgeniya A Pimenova, Irina V Sorokina
The possibility of using different types of carrageenans (CRG) as matrixes for incorporating of echinochrome A (Ech) was investigated. Ech interacts with carrageenans and is incorporated into the macromolecular structure of the polysaccharide. The inclusion of Ech in carrageenan matrices decreased its oxidative degradation and improved its solubility. The changing in the charge and morphology of CRGs during binding with Ech was observed. The rate of Ech release from CRG matrices depended on the structure of the used polysaccharide and the presence of specific ions...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29101812/the-effect-of-ketorolac-and-triamcinolone-acetonide-on-adipogenic-and-hepatogenic-differentiation-through-mirnas-16-15-195-possible-clinical-application-in-regenerative-medicine
#18
Sedigheh Fekri Aval, Nosratollah Zarghami, Effat Alizadeh, Seyed Abolghasem Mohammadi
OBJECTIVE: The role of miR-16/15b/195 and complementary compounds in the commitment of mesenchymal stem cells (MSCs) to different lineages is unknown. The aim of this work was to investigate the effect of ketorolac and triamcinolone acetonide on adipogenic and hepatogenic processes, respectively. Also, miR-16/15 and miR-195 expression levels were evaluated under different induction conditions. METHODS: MSCs were isolated, expanded and directed using adipogenesis medium or medium supplemented with ketorolac, and also subjected to hepatogenic differentiation using a cocktail of hepatocyte growth factor (HGF) and Oncostatin M (OSM) either with or without triamcinolone acetonide...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29099894/effects-of-platelet-rich-plasma-and-indomethacin-on-biomechanics-of-rotator-cuff-repair
#19
Molly C Meadows, David M Levy, Christopher M Ferry, Thomas R Gardner, Takeshi Teratani, Christopher S Ahmad
We conducted a study to determine if platelet-rich plasma (PRP) enhances the strength of rotator cuff repair (RCR) and if concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) affects PRP efficacy. We also wanted to determine the optimal centrifugation protocol for making PRP from rats. This study used 48 rats, 14 in a centrifugation protocol and 34 in an operative protocol. Six syngeneic rats from the operative group were used as PRP blood donors; the other 28 operative rats underwent bilateral RCRs...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29097142/exploring-the-feasibility-of-the-use-of-biopolymers-as-a-carrier-in-the-formulation-of-amorphous-solid-dispersions-part-i-gelatin
#20
Timothy Pas, Bjorn Vergauwen, Guy Van den Mooter
Biopolymers have rarely been used so far as carriers in the formulation of amorphous solid dispersions (ASD) to overcome poor solubility of active pharmaceutical ingredients (APIs). In an attempt to enlarge our knowledge on this topic, gelatin, type 50PS was selected. A screening study was initiated in which twelve structurally different poorly soluble biopharmaceutical classification system (BCS) Class II drugs (carbamazepine, cinnarizine, diazepam, itraconazole, nifedipine, indomethacin, darunavir (ethanolate), ritonavir, fenofibrate, griseofulvin, ketoconazole and naproxen) were selected for evaluation...
October 31, 2017: International Journal of Pharmaceutics
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