keyword
MENU ▼
Read by QxMD icon Read
search

indomethacin

keyword
https://www.readbyqxmd.com/read/27914176/prophylactic-rectal-indomethacin-may-be-ineffective-for-preventing-post-ercp-pancreatitis-in-general-patients-a-meta-analysis
#1
REVIEW
Yunlu Feng, Udayakumar Navaneethan, Xiang Zhu, Shyam Varadarajulu, Ingrid Schwartz, Robert H Hawes, Muhammad K Hasan, Aiming Yang
BACKGROUND AND AIMS: The efficacy of prophylactic indomethacin for prevention of post-ERCP pancreatitis (PEP) in general patients remains controversial. To address this, we therefore conducted a meta-analysis of clinical trials specifically on rectal indomethacin in prevention of PEP in consecutive patients undergoing ERCP. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases to identify randomized, double-blinded, controlled clinical trials on rectal indomethacin in prevention of PEP in consecutive patients undergoing ERCP...
December 3, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27913816/genetic-ablation-or-pharmacologic-inhibition-of-autophagy-mitigated-nsaid-associated-gastric-damages
#2
Chan Young Ock, Jong-Min Park, Young-Min Han, Migyeong Jeong, Mi-Young Kim, Ho Jae Lee, Ki Baik Hahm
: Non-steroidal anti-inflammatory drug (NSAID)-associated endoplasmic reticulum (ER) stress (a cyclooxygenase-2-independent mechanism) and consequent autophagic cell death are responsible for NSAID-associated gastric damage. Therefore, alleviating cytotoxicity executed via ER stress and autophagy can be a strategy to prevent NSAID-associated gastric damage. Here, we explored whether genetic or pharmacologic inhibition of autophagy can mitigate NSAID-associated gastric damage in in vitro and in vivo models...
December 2, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27898408/sulodexide-protects-contrast-induced-nephropathy-in-sprague-dawley-rats
#3
Qing Zhao, Jianyong Yin, Zeyuan Lu, Yiwei Kong, Guangyuan Zhang, Binghui Zhao, Feng Wang
BACKGROUND: Sulodexide is a powerful antithrombin agent with reno-protective property. However, whether it has beneficial effects on Contrast-Induced Nephropathy (CIN) remained elusive. In the current study, we evaluated the therapeutic effects of Sulodexide on CIN and investigated the potential mechanisms. METHODS: CIN model was induced by intravenous injection of indomethacin, followed by Ioversol and L-NAME. Sprague-Dawley rats were divided into 4 groups: control group, CIN group, CIN+vehicle group (CIN rats pretreated with vehicle) and CIN+ Sulodexide (CIN rats pretreated with Sulodexide)...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27896585/effect-of-an-herbal-mixture-of-cinnamon-cortex-persicae-semen-and-natril-sulfas-on-collagen-induced-arthritis-and-lipopolysaccharides-induced-nuclear-factor-%C3%AE%C2%BA-b-signaling
#4
Ji-Won Lee, Jae-Hwan Lew, Tae-Woo Kim, Hee Kang
OBJECTIVE: To investigate the anti-arthritic and anti-inflammatory effects of the mixture of three herbal agents, Cinnamon Cortex, Persica Semen, and Natril Sulfas (CPN), the major ingredients of Taoren Chengqi Decoction (). METHODS: Collagen-induced arthritis (CIA) was induced by immunization with bovine type II collagen on day 1 and 21. DBA/1J mice were orally administered the water extract of CPN (100 and 500 mg/kg) and indomethacin (1 mg/kg) or vehicle (water) 3 times per week for 6 weeks...
November 17, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27890711/the-endogenous-lipid-n-arachidonoyl-glycine-is-hypotensive-and-nitric-oxide-cgmp-dependent-vasorelaxant
#5
Yousuf M Al Suleimani, Ahmed S Al Mahruqi
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance arteries. This study investigates its hemodynamic effects and mechanisms of vasorelaxation. Hemodynamic effects of NAGLY in rats were assessed using a Biopac system and its vascular responses were assessed using a wire myograph. NAGLY (1 mg/kg) decreased blood pressure by 69.4 ± 5.5% and reduced renal blood flow by 88 ± 12% and the effects were not sensitive to inhibition by O-1918 (3 mg/kg)...
November 24, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27890595/the-formation-and-physical-stability-of-two-phase-solid-dispersion-systems-of-indomethacin-in-supercooled-molten-mixtures-with-different-matrix-formers
#6
Kristian Semjonov, Karin Kogermann, Ivo Laidmäe, Osmo Antikainen, Clare J Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki
Amorphous solid dispersions (SDs) are a promising approach to improve the dissolution rate of and oral bioavailability of poorly water-soluble drugs. In some cases multi-phase, instead of single-phase, SD systems with amorphous drug are obtained. While it is widely assumed that one-phase amorphous systems are desirable, two-phase systems may still potentially exhibit enhanced stability and dissolution advantages over undispersed systems. The objective of the present study was to understand the solid-state properties of two-phase SDs with amorphous drug and their relation to physical stability...
November 23, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27888143/dissolution-behavior-of-co-amorphous-amino-acid-indomethacin-mixtures-the-ability-of-amino-acids-to-stabilize-the-supersaturated-state-of-indomethacin
#7
Rami Ojarinta, Aki T Heikkinen, Elina Sievänen, Riikka Laitinen
Arginine, phenylalanine, and tryptophan have been previously shown to improve the solid-state stability of amorphous indomethacin. The present study investigates the ability of these amino acids to prolong the supersaturation of indomethacin in both aqueous and biorelevant conditions either when freely in solution or when formulated as co-amorphous mixtures. The co-amorphous amino acid-indomethacin mixtures (molar ratio 1:1) and amorphous indomethacin were prepared by cryomilling. Dissolution and precipitation tests were performed in buffer solutions (pH 5 and 6...
November 22, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27886112/synthesis-characterization-and-anti-inflammatory-activities-of-methyl-salicylate-derivatives-bearing-piperazine-moiety
#8
Jingfen Li, Yong Yin, Lisheng Wang, Pengyun Liang, Menghua Li, Xu Liu, Lichuan Wu, Hua Yang
In this study, a new series of 16 methyl salicylate derivatives bearing a piperazine moiety were synthesized and characterized. The in vivo anti-inflammatory activities of target compounds were investigated against xylol-induced ear edema and carrageenan-induced paw edema in mice. The results showed that all synthesized compounds exhibited potent anti-inflammatory activities. Especially, the anti-inflammatory activities of compounds M15 and M16 were higher than that of aspirin and even equal to that of indomethacin at the same dose...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27884639/amphiphilic-poly-n-vinylpyrrolidone-nanoparticles-as-carriers-for-non-steroidal-anti-inflammatory-drugs-in-vitro-cytotoxicity-and-in-vivo-acute-toxicity-study
#9
Andrey N Kuskov, Pavel P Kulikov, Anastasia V Goryachaya, Manolis N Tzatzarakis, Anca O Docea, Kelly Velonia, Michael I Shtilman, Aristidis M Tsatsakis
Polymeric nanoparticles were prepared from self-assembled amphiphilic N-vinylpyrrolidone polymers in aqueous media and evaluated as novel carriers of indomethacin, a non-steroidal, anti-inflammatory drug. It was determined that these nanoparticles could be created in spherical morphologies with sizes less than 100nm, narrow size distributions and high indomethacin contents(up to 35%) combined with high drug loading efficiencies(up to 95%). In cytotoxicity tests using the human embryonic stem cell derived fibroblasts (EBF-H9) and hepatocellular carcinoma cells (HepG2), the indomethacin-loaded polymeric nanoparticles showed higher cell viability compared to that of free indomethacin at the same concentration...
November 21, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27883262/phytochemicals-enhance-antioxidant-enzyme-expression-to-protect-against-nsaid-induced-oxidative-damage-of-the-gastrointestinal-mucosa
#10
REVIEW
Yu-Ting Cheng, Chi-Cheng Lu, Gow-Chin Yen
The gastrointestinal mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to gastrointestinal damage, such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and haven been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27881647/activation-of-cox-2-pge2-promotes-sapovirus-replication-via-the-inhibition-of-nitric-oxide-production
#11
Mia Madel Alfajaro, Jong-Soon Choi, Deok-Song Kim, Ja-Young Seo, Ji-Yun Kim, Jun-Gyu Park, Mahmoud Soliman, Yeong-Bin Baek, Eun-Hyo Cho, Joseph Kwon, Hyung-Jun Kwon, Su-Jin Park, Woo Song Lee, Mun-Il Kang, Myra Hosmillo, Ian Goodfellow, Kyoung-Oh Cho
: Enteric caliciviruses in the genera Norovirus and Sapovirus are important pathogens that cause severe acute gastroenteritis in both humans and animals. Cyclooxygenases (COXs) and their final product prostaglandin E2 (PGE2) are known to play important roles in the modulation of both the host response to the infection and replicative cycle of several viruses. However, the precise mechanism(s) by which the COXs/PGE2 pathway regulates sapoviruses replication remains largely unknown. In this study, the infection of porcine sapovirus (PSaV) Cowden strain, the only cultivable virus within the genus Sapovirus, markedly increased COX-2 mRNA and protein levels at 24 and 36 hours post-infection (hpi) with only a transient increase of COX-1 levels seen at 24 hpi...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27880955/long-term-angiotensin-ii-receptor-blockade-limits-hypertension-aortic-dysfunction-and-structural-remodeling-in-a-rat-model-of-chronic-kidney-disease
#12
Omar Z Ameer, Mark Butlin, Elena Kaschina, Manuela Sommerfeld, Alberto P Avolio, Jacqueline K Phillips
BACKGROUND/AIMS: Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 receptor inhibition with valsartan on aortic function and structure in the Lewis polycystic kidney (LPK) rat model of CKD. METHODS: Mixed sex LPK and Lewis control (total n = 28) treated (valsartan 60 mg/kg/day p.o. from 4 to 18 weeks) and vehicle groups were studied...
November 24, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27878455/structural-insight-into-binding-mode-of-9-hydroxy-aristolochic-acid-diclofenac-and-indomethacin-to-pla2
#13
Mohsen Ebrahimi, Omidreza Firuzi, Ramin Miri, Nima Razzaghi-Asl, Ahmad Ebadi
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is modified by cyclooxygenases into active compounds called eicosanoids that act as signaling molecules in a number of physiological processes. Excessive production of eicosanoids leads to several pathological conditions such as inflammation. In order to block the inflammatory effect of these compounds, upstream enzymes such as PLA2 are valid targets. In the present contribution, molecular dynamic analysis was performed to evaluate the binding of diclofenac, 9-hydroxy aristolochic acid (9-HAA) and indomethacin to PLA2...
November 22, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27872694/long-term-treatment-by-vitamin-b1-and-reduction-of-serum-proinflammatory-cytokines-hyperalgesia-and-paw-edema-in-adjuvant-induced-arthritis
#14
Jalal Zaringhalam, Akhtar Akbari, Alireza Zali, Homa Manaheji, Vida Nazemian, Mahdi Shadnoush, Somayeh Ezzatpanah
INTRODUCTION: Immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. Given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin B1 on the proinflammatory cytokines, edema, and hyperalgesia during the acute and chronic phases of adjuvant-induced arthritis. METHODS: On the first day of study, inflammation was induced by intraplantar injection of complete Freund's adjuvant (CFA) in the hindpaws of rats...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27871896/gastroprotective-and-ulcer-healing-effects-of-hydroethanolic-extract-of-leaves-of-caryocar-coriaceum-mechanisms-involved-in-the-gastroprotective-activity
#15
Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes
This work aimed to determine the chemical fingerprint of hydroethanolic extract of leaves of Caryocar coriaceum (HELCC) and the gastroprotective activity. The chemical fingerprint of HELCC was analyzed by HPLC-DAD, to quantify total phenols and flavonoids were carried out by Folin-Ciocalteu reagent and aluminum chloride assay, while in vitro antioxidant activity was evaluated by the DPPH method. The methods used to determine pharmacological activity were: gastroprotective screening test in classical models of induced acute and chronic gastric lesions and physical barrier test...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871194/lipopolysaccharide-reduces-food-passage-rate-from-the-crop-by-a-prostaglandin-independent-mechanism-in-chickens
#16
T Tachibana, M Ogino, R Makino, M S I Khan, M A Cline
We examined the effect of lipopolysaccharide (LPS), a component of Gram-negative bacteria, on food passage in the digestive tract of chickens (Gallus gallus) in order to clarify whether bacterial infection affects food passage in birds. Food passage in the crop was significantly reduced by intraperitoneal (IP) injection of LPS while it did not affect the number of defecations, suggesting that LPS may affect food passage only in the upper digestive tract. Similar to LPS, prostaglandin E2 (PGE2), one of the mediators of LPS, also reduced crop-emptying rate in chickens while it had no effect on the number of defecations...
December 2, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27867110/poly-%C3%AE%C2%B5-benzyloxycarbonyl-l-lysine-grafted-branched-polyethylenimine-as-efficient-nanocarriers-for-indomethacin-with-enhanced-oral-bioavailability-and-anti-inflammatory-efficacy
#17
Chao Lu, Xin Li, Wenquan Xia, Siheng Lu, Hongjun Luo, Danyan Ye, Yanmei Zhang, Daojun Liu
: Star-block copolymers PEI-g-PZLL with a branched polyethylenimine (PEI) core and multiple grafted poly(ε-benzyloxycarbonyl-L-lysine) (PZLL) peripheral chains were designed, synthesized, and evaluated as nanocarriers for indomethacin (IND). In an aqueous solution, PEI-g-PZLL self-assembled into spherical nanoparticles capable of encapsulating IND at high loading capacity and loading efficiency. Differential scanning calorimetry and X-ray diffraction measurements indicated that IND was molecularly or amorphously dispersed in the nanoparticles...
November 17, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27864128/prostaglandin-e2-activates-yap-and-a-positive-signaling-loop-to-promote-colon-regeneration-following-colitis-but-also-carcinogenesis-in-mice
#18
Han-Byul Kim, Minchul Kim, Young-Soo Park, Intae Park, Tackhoon Kim, Sung-Yeun Yang, Charles J Cho, DaeHee Hwang, Jin-Hak Jung, Sanford D Markowitz, Sung Wook Hwang, Suk-Kyun Yang, Dae-Sik Lim, Seung-Jae Myung
BACKGROUND & AIMS: Prostaglandin E2 (PGE2) is mediator of inflammation that regulates tissue regeneration, but its continual activation has been associated with carcinogenesis. Little is known about factors in the PGE2 signaling pathway that contribute to tumor formation. We investigated whether yes associated protein 1 (YAP1), a transcriptional co-activator in the Hippo signaling pathway, mediates PGE2 function. METHODS: DLD-1 and SW480 colon cancer cell lines were transfected with vectors expressing transgenes or small hairpin RNAs and incubated with recombinant PGE2, with or without pharmacologic inhibitors of signaling proteins, and analyzed by immunoblot, immunofluorescence, quantitative reverse transcription PCR, transcriptional reporter, and proliferation assays...
November 15, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27862196/synthesis-and-biological-evaluation-of-novel-indomethacin-derivatives-as-potential-anti-colon-cancer-agents
#19
Amel Mostafa Farrag
The molecular structure of indomethacin was used as a starting scaffold for the synthesis of 20 novel analogs and to study their effects on the proliferation of three human colon cancer cell lines, HCT-116, HT-29, and Caco-2, by MTT assay. The synthesized indomethacin analogs were characterized on the basis of IR, (1) H NMR, (13) C NMR, mass spectral data, and elemental analysis results. Cytotoxicity assay results showed that the indomethacin amide analog 2 was the most potent anticancer agent (IC50  = 0...
December 2016: Archiv der Pharmazie
https://www.readbyqxmd.com/read/27861830/hemicrania-continua-beneficial-effect-of-non-invasive-vagus-nerve-stimulation-in-a-patient-with-a-contraindication-for-indomethacin
#20
Ozan Eren, Andreas Straube, Florian Schöberl, Christoph Schankin
Hemicrania continua (HC) is a primary chronic headache disorder, characterized by a continuous and strictly unilateral headache, with possible cranial autonomic symptoms during episodes of pain exacerbation. The unilateral headache generally responds well to indomethacin; however, continuous indomethacin intake is often not tolerated due to severe adverse effects, like hypertension, gastrointestinal discomfort (especially if combined with aspirin), slightly increased risk of vascular events, and bronchial spasms...
November 11, 2016: Headache
keyword
keyword
109312
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"