Daniel A N Barbosa, Sandra Gattas, Juliana S Salgado, Fiene Marie Kuijper, Allan R Wang, Yuhao Huang, Bina Kakusa, Christoph Leuze, Artur Luczak, Paul Rapp, Robert C Malenka, Dora Hermes, Kai J Miller, Boris D Heifets, Cara Bohon, Jennifer A McNab, Casey H Halpern
Only recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing1-4 . This function has been reported to be mediated at least in part by lateral hypothalamic inputs, including those involving orexigenic lateral hypothalamic neuropeptides, such as melanin-concentrating hormone5,6 . This circuit, however, remains elusive in humans. Here we combine tractography, intracranial electrophysiology, cortico-subcortical evoked potentials, and brain-clearing 3D histology to identify an orexigenic circuit involving the lateral hypothalamus and converging in a hippocampal subregion...
August 30, 2023: Nature