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idiopathic inflammatory myopathy

Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Abdullah Mahmood, Mitchell Hare, Nicholas Taklalsingh, Isabel M McFarlane
Idiopathic inflammatory myopathy (IIM) is a rare autoimmune myopathy that includes polymyositis, dermatomyositis, inclusion body myositis and autoimmune necrotizing myositis. Cardiac involvement was considered a rare occurrence in IIM however, recent reports suggests that cardiac involvement is a common feature and portends poor prognosis as it is usually encountered in advanced disease. IIM leads to myocarditis with subsequent development of myocardial fibrosis, cardiac conduction system disease and cardiomyopathy resulting in both systolic and diastolic heart failure...
2018: American journal of medical case reports
Christopher A Mecoli, Jin Kyun Park, Helene Alexanderson, Malin Regardt, Merrilee Needham, Ingrid de Groot, Catherine Sarver, Ingrid E Lundberg, Beverley Shea, Marianne de Visser, Yeong Wook Song, Clifton O Bingham, Lisa Christopher-Stine
OBJECTIVE: Patient-reported outcome measures (PROM) that incorporate the patient perspective have not been well established in idiopathic inflammatory myopathies (IIM). As part of our goal to develop IIM-specific PROM, the Outcome Measures in Rheumatology (OMERACT) Myositis special interest group sought to determine which aspects of disease and its effects are important to patients and healthcare providers (HCP). METHODS: Based on a prior qualitative content analysis of focus groups, an initial list of 24 candidate domains was constructed...
September 15, 2018: Journal of Rheumatology
Buenaventura Brito Díaz, Delia Almeida González, Fadoua Gannar, M Cristo Rodríguez Pérez, Antonio Cabrera de León
Myokines are peptides produced and released by myocytes of muscle fibers that influence physiology of muscle and other organs and tissues. They are involved in mediating the beneficial effects that exercise has on health. More than one hundred have been identified and among them are IL6, myostatin, irisin, mionectin and decorin. Physical inactivity leads to an altered response of the secretion of myokines and resistance to them; this leads to a pro-inflammatory state that favors sarcopenia and fat accumulation, promoting the development of cardiovascular diseases, insulin resistance, and diabetes mellitus type 2...
September 5, 2018: Immunology Letters
Satoshi Kubo, Yasuyuki Todoroki, Shingo Nakayamada, Kazuhisa Nakano, Minoru Satoh, Aya Nawata, Yurie Satoh, Ippei Miyagawa, Kazuyoshi Saito, Vanessa Smith, Maurizio Cutolo, Yoshiya Tanaka
Objective: The aim of this study was to investigate the clinical and immunological significance of nailfold videocapillaroscopy (NVC) abnormalities in patients with idiopathic inflammatory myopathies (IIMs). Methods: Seventy consecutive Japanese patients with untreated IIMs, enrolled between April 2014 and August 2017, were prospectively studied. Clinical features, NVC findings, autoantibody profile by immunoprecipitation and ELISA, and histopathological findings of skin biopsies of DM rash were assessed at baseline and after 1-year of immunosuppressive therapy...
August 28, 2018: Rheumatology
Karina Rotella, Milena Rodriguez Alvarez, Yair Saperstein, Manjeet S Bhamra, Su Zhaz Leon, Alekznder Feoktiztov, Isabel MFarlane
Idiopathic inflammatory myopathies are rare autoimmune disorders characterized by proximal muscle weakness, elevation of muscle enzymes, abnormal electromyogram and imaging studies revealing areas of edema and inflammation. Initial approach to inflammatory myopathies includes steroids and immunosuppressive agents, with most individuals responding satisfactorily to therapy. However, treatment-refractory myopathies prompts clinicians to use second line agents to achieve remission. In this case series, we describe three patients with refractory idiopathic inflammatory myopathies who were treated with tacrolimus (TAC) added to mycophenolate mofetil (MMF) and steroid therapy, who achieved clinical and biochemical remission...
2018: Rheumatology: Current Research
Miranda Houtman, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M Reed, Ingrid E Lundberg, Leonid Padyukov
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell infiltrates in muscle tissue. In PM, a major component of inflammatory cell infiltrates is CD8+ T cells, whereas in DM, CD4+ T cells, plasmacytoid dendritic cells, and B cells predominate. In this study, with the aim to differentiate involvement of CD4+ and CD8+ T-cell subpopulations in myositis subgroups, we investigated transcriptomic profiles of T cells from peripheral blood of patients with myositis...
August 29, 2018: Arthritis Research & Therapy
Mehrzad Hajialilo, Amir Ghorbanihaghjo, Alireza Khabbazi, Sousan Kolahi, Mohammad Reza Jafari Nakhjavani, Ali Asghar Ebrahimi, Hamid Zareh, Aida Malek Mahdavi
AIM: This study aimed to follow up patients with polymyositis (PM) and/or dermatomyositis (DM) to determine survival rate, pattern of disease, response to treatment, malignancy incidence and poor prognostic factors (PPFs). METHOD: A total of 76 patients with PM (n = 47) and/or DM (n = 29) based on Bohan and Peter diagnostic criteria referred to the Imam-Reza Hospital were followed up from 2004 to 2016. The follow-up period was considered from diagnosis to patient's death or last visit...
August 2018: International Journal of Rheumatic Diseases
Qing-Lin Peng, Jin-Ming Lin, Yong-Biao Zhang, Xue-Zhi Zhang, Pan-Pan Wang, Ting-Ting Wu, Jun Yu, Xiao-Qun Dong, Ming-Liang Gu, Guo-Chun Wang
OBJECTIVES: Previous association studies have identified genetic variants in the human leukocyte antigen (HLA) complex as substantial risk factors for idiopathic inflammatory myopathies (IIMs). However, a great number of genes are located in the HLA region, and thus fine mapping is quite necessary. METHODS: Targeted capture sequencing were performed on the whole HLA region in 42 IIM patients and 24 healthy controls. A microarray analysis was applied to analyze gene expression profiles in additional 20 newly diagnosed IIM and five healthy controls...
August 2018: International Journal of Rheumatic Diseases
Evangelia Zampeli, Aliki Venetsanopoulou, Ourania D Argyropoulou, Clio P Mavragani, Maria G Tektonidou, Panayiotis G Vlachoyiannopoulos, Athanasios G Tzioufas, Fotini N Skopouli, Haralampos M Moutsopoulos
Myositis-specific (MSAs) or-associated autoantibodies (MAAs) have been linked to particular clinical phenotypes of idiopathic inflammatory myopathies (IIM) and appear to aid diagnosis. The objective of this study was to analyze the prevalence of MSAs and MAAs and their possible clinical associations in Greek IIM patients. This study comprised 95 IIM patients classified based on the 2017 EULAR/ACR classification criteria. All patients had MSAs and MAAs measured in their sera by line immunoblot assay. Dermatomyositis was the most prevalent IIM clinical subtype...
August 25, 2018: Clinical Rheumatology
Alexander Oldroyd, Hector Chinoy
PURPOSE OF REVIEW: The aim of this review was to summarize key developments in classification and diagnosis of the idiopathic inflammatory myopathies (IIMs). RECENT FINDINGS: The recently published European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for the IIMs provide a comprehensive, accurate and data-driven approach to identification of IIM cases appropriate for inclusion in research studies. Further, recent studies have advanced understanding of clinical manifestations of the IIMs and delineated the role of imaging, particularly magnetic resonance...
August 22, 2018: Current Opinion in Rheumatology
Veerle Ide, Xavier Bossuyt, Daniël Blockmans, Ellen De Langhe
Objective: As rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPAs) are not routinely tested in idiopathic inflammatory myositis (IIM), little is known about their prevalence and clinical implications in this patient group. In antisynthetase syndrome (ASS), presence of ACPA is reportedly associated with more severe and erosive arthritis. We aim to retrospectively determine the prevalence of RF and ACPA in a cross-sectional cohort of 121 patients diagnosed with IIM and to assess clinical associations...
2018: RMD Open
Juqiang Han, Shuai Wang, Thomas Ngai Yeung Kwong, Jian Liu
RATIONALE: Dermatomyositis is an idiopathic inflammatory myopathy with specific cutaneous manifestations, which is closely associated with malignancy. However, the exact mechanism remains elusive. Even less is known about dermatomyositis with hepatocellular carcinoma (HCC). PATIENT CONCERNS: We reported a case of dermatomyositis with hepatitis B virus (HBV) infection. He incidentally found his lower limbs little weakness accompanied with his wrist erythema. He was found HBsAg positive for forty years with slightly positive of α-fetal protein (AFP)...
August 2018: Medicine (Baltimore)
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No abstract text is available yet for this article.
September 2018: Annals of the Rheumatic Diseases
Leandro Ladislau, Louiza Arouche-Delaperche, Yves Allenbach, Olivier Benveniste
PURPOSE OF REVIEW: This review provides an overview of the potential pathogenic roles of anti-SRP and anti-HMGCR in IMNM over the past 5 years. RECENT FINDINGS: Idiopathic inflammatory myopathies (IIM) are a group of acquired autoimmune disorders that mainly affect the skeletal muscle tissue. Classification criteria of IIM are comprised of polymyositis, dermatomyositis, inclusion body myositis and immune-mediated necrotizing myopathies. One important hallmark of autoimmune diseases is the detection of autoantibodies in patient sera...
August 3, 2018: Current Rheumatology Reports
Jaka Ostrovršnik, Alojzija Hočevar, Žiga Rotar, Monika Krošel, Saša Čučnik, Vesna Jurčić, Matija Tomšič
Idiopathic Inflammatory myopathies (IIM) are rare disorders. The aim of our study was to determine the incidence of IIM in a well-defined Slovenian region. This retrospective study was conducted at the Department of Rheumatology, University Medical Centre Ljubljana, the only secondary/tertiary rheumatology center in a region with a population of 704,342 adults. We identified potential IIM cases by searching the electronic patient records for ICD-10 codes M33, M35.1, M35.8, M60, G72, G73, and J84. We included incipient IIM cases between January 2010 and December 2017, who were at the time of the diagnosis, residents of the inspected region...
August 2, 2018: Clinical Rheumatology
Gillian E Caughey, Genevieve M Gabb, Saffron Ronson, Michael Ward, Timothy Beukelman, Catherine L Hill, Vidya Limaye
Importance: Statin medications are widely prescribed for cardiovascular risk reduction. Myalgia and rhabdomyolysis are well-recognized adverse effects of statins, and they resolve with the cessation of statin therapy. Idiopathic inflammatory myositis (IIM) is a heterogeneous group of autoimmune myopathies that may also be associated with statin use. Recently, statin-associated autoimmune myopathy has been recognized as a distinct entity with the presence of specific autoantibodies against hydroxymethylglutaryl-coenzyme A reductase, which results in a necrotizing myositis that does not resolve with cessation of statin therapy and requires treatment with immunosuppressive agents...
September 1, 2018: JAMA Internal Medicine
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Samuel Katsuyuki Shinjo
BACKGROUND: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. OBJECTIVES: To analyze this autoantibody in the Brazilian population. METHODS: This was a single-center cross-sectional study in which 131 consecutive adult patients (109 dermatomyositis and 22 clinically amyopathic dermatomyositis) with active disease were evaluated from 2000 to 2016...
July 2018: Anais Brasileiros de Dermatologia
Namita A Goyal, Tahseen Mozaffar
PURPOSE OF REVIEW: The purpose of this review is to update the audience on the recent progress in the treatment of idiopathic inflammatory myopathies, highlighting a myriad of treatment trials aimed at slowing down progression of muscle weakness and/or skin involvement in idiopathic inflammatory myopathies. RECENT FINDINGS: Myositis continues to be an active area of clinical and translational research. Through the work of a number of investigators, we now have a much better understanding of the pathogenesis underlying the various myositides...
July 23, 2018: Current Treatment Options in Neurology
Adam M Huber
The juvenile idiopathic inflammatory myopathies (JIIM) are a group of rare, chronic, autoimmune illnesses that affect muscle and, to a lesser extent, skin. The presence of new-onset weakness and, in juvenile dermatomyositis, typical rahes, should lead to consideration of these diagnoses. Careful evaluation to exclude alternative diagnoses is needed. Investigations include a variety of blood tests, imaging, and possibly muscle biopsy. Validated clinical assessments are available for monitoring. Standard treatment includes corticosteroids and methotrexate and often extends beyond 1 year...
August 2018: Pediatric Clinics of North America
John Svensson, Ingrid E Lundberg, Mia Von Euler, Elizabeth V Arkema, Marie Holmqvist
OBJECTIVE: To study the occurrence of ischemic (IS) and haemorrhagic stroke (HS) in idiopathic inflammatory myopathies (IIM) compared to the general population and to investigate how it varies by sex, age, clinical sub-diagnosis and time since IIM diagnosis. METHODS: All newly diagnosed IIM patients in Sweden were identified from the National Patient Register and general population comparators were identified from the Total Population Register. The study population was followed prospectively until death, emigration, December 2013 or first incident stroke...
July 12, 2018: Arthritis Care & Research
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