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idiopathic inflammatory myopathy

Linqing Zhong, Zhongxun Yu, Hongmei Song
BACKGROUND: Several complications like calcinosis, interstitial lung disease (ILD) or malignancy, are primary causes leading to poor outcomes in idiopathic inflammatory myopathies (IIM) patients. Specific antibodies might help to indicate the occurrence or absence of these complications. OBJECTIVE: The aim of this study was to evaluate the association of anti-nuclear matrix protein 2 antibody (anti-NXP2) with calcinosis, ILD and malignancy in IIM patients. METHODS: Two investigators independently searched literature about the relation of anti-NXP2 with calcinosis, ILD, malignancy in IIM patients in PubMed, EMBASE, Web of Science databases, then selected eligible articles and extracted data from the included studies...
November 13, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Andrés Tirado-Sánchez, Alexandro Bonifaz, Rosa María Ponce-Olivera
Introduction: Dermatomyositis is an autoimmune disease and the most common idiopathic inflammatory myopathy. During patient follow-up, determining biochemical parameters is required in order to assess for disease activity and treatment efficacy. Objective: To determine the relationship between the degree of activation of the complement system through the soluble membrane attack complex (c5b-9), dermatomyositis clinical activity and its variations with conventional treatment...
2018: Gaceta Médica de México
Young Kim, Kyu Sang Song, Eun Hee Sohn, Seong Wook Kang, In Seol Yoo, Seung-Cheol Shim, Su-Jin Yoo, Jinhyun Kim
OBJECTIVE: Anti-transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression of TIF1s in IIMs. METHOD: TIF1α, β or γ expression in the skin and muscle of patients and controls was studied by immunohistochemistry. Serum myositis-specific autoantibodies were detected by immunoblot. RESULTS: TIF1α was expressed in the skin of most dermatomyositis (DM) patients but not in the controls (80% vs 0%, P < 0...
November 5, 2018: International Journal of Rheumatic Diseases
Tatiana Cobo-Ibáñez, Francisco-Javier López-Longo, Beatriz Joven, Patricia E Carreira, Santiago Muñoz-Fernández, Valentina Maldonado-Romero, Carmen Larena-Grijalba, Irene Llorente Cubas, Eva Tomero Muriel, Carmen Barbadillo Mateos, Paloma García de la Peña Lefebvre, Alejandro Gomez-Gomez, Laura Barrio Nogal, Ana Pérez, Raquel Almodovar, Leticia Lojo, Lucía Ruiz-Gutiérrez, Juan Carlos López-Robledillo, María Jesús García de Yébenes, Laura Nuño-Nuño
OBJECTIVE: To study prognostic factors in different types of idiopathic inflammatory myopathies (IIM) associated with interstitial lung disease (ILD). PATIENTS AND METHODS: Multicenter retrospective study of a Spanish cohort of patients diagnosed with IIM. Patients were classified into four categories: polymyositis (PM), dermatomyositis (DM), antisynthetase syndrome (ASS), and overlap myositis (OM). Sociodemographic data, clinical characteristics, antibodies, and treatments were collected...
November 3, 2018: Clinical Rheumatology
Thuy Nguyen Thi Phuong, Lan Nguyen Thi Ngoc, Hien Nguyen Xuan, Johan Rönnelid, Leonid Padyukov, Ingrid E Lundberg
No abstract text is available yet for this article.
October 26, 2018: Rheumatology
Maya Antoine, Patrick T Reeves, Luis Rohena, Olcay Jones, Brian Faux
Juvenile dermatomyositis (JDM) is a rare, but well recognized multi-systemic inflammatory myopathy in children defined by proximal muscle weakness and distinctive skin lesions, that if recognized and treated early result in decreased morbidity and mortality. The 1975 criteria established by Bohan and Peter center around the propensity for early development of heliotrope and Gottron's lesions in combination with specific laboratory abnormalities, and are still the leading diagnostic tool. The following case demonstrates a toddler with an atypical presentation of JDM in which delayed dermatologic manifestations hindered initial diagnosis...
November 2018: Journal of Clinical Medicine Research
Paula Fernández-Rodríguez, Juan José Martín-Marcuartu, Jose Manuel Jiménez-Hoyuela
We present a 44-year-old woman with scapular and pelvic muscle weakness, joint inflammation, and fever. Bone scintigraphy showed high uptake in proximal regions of upper and lower limbs, suspecting inflammatory myopathy and polyarticular damage. These features were the clue to request other complementary tests such as anti-aminoacyl-tRNA-synthetase antibodies and chest CT, which showed interstitial lung disease, defining an antisynthetase syndrome. Therefore, BS allows an earlier diagnosis of inflammatory muscle disease and to identify the optimal site for muscle biopsy...
October 15, 2018: Clinical Nuclear Medicine
Cécile Bergua, Hélène Chiavelli, Yves Allenbach, Louiza Arouche-Delaperche, Christophe Arnoult, Gwladys Bourdenet, Laetitia Jean, Rachid Zoubairi, Nicolas Guerout, Michael Mahler, Olivier Benveniste, Laurent Drouot, Olivier Boyer
OBJECTIVES: In autoimmunity, autoantibodies (aAb) may be simple biomarkers of disease or true pathogenic effectors. A form of idiopathic inflammatory myopathy associated with anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) aAb has been individualised and is referred to as immune-mediated necrotising myopathy (IMNM). The level of aAb correlates with IMNM activity and disease may respond to immunosuppression, suggesting that they are pathogenic...
October 11, 2018: Annals of the Rheumatic Diseases
Katerina Kubínová, R Dejthevaporn, Herman Mann, Pedro M Machado, Jiří Vencovský
OBJECTIVES: To describe imaging modalities for diagnosing and monitoring of patients with idiopathic inflammatory myopathies. METHODS: A detailed literature search summarising recent data documenting the contribution of different imaging techniques to current management of idiopathic inflammatory myopathies was performed. RESULTS: An overview of methods most frequently used for evaluation of inflammatory myopathies and the description of their role in the diagnostic and monitoring process is presented...
September 2018: Clinical and Experimental Rheumatology
Ekkehard Genth
Idiopathic inflammatory myopathies (IIM) are a rare and clinically polymorphic and heterogenous group of myositis syndromes. Myositis is part of a systemic autoimmune disorder with various extramuscular manifestations affecting skin, lungs, joints, esophagus and other organ systems. Most myositis patients have autoantibodies against non organspecific antigens. More than 20 different autoantibodies are known. They are associated with different clinical phenotypes of adult or juvenile dermatomyositis or myositis-overlap syndromes and different genetic markers...
October 2018: Deutsche Medizinische Wochenschrift
María Victoria Collado, María De Los Ángeles Gargiulo, Ramiro Gómez, Graciela Gómez, Nicolás Pérez, Lorena Suarez, Ana Lía Taratuto, Patricia Aruj
Dematomyositis is an idiopathic inflammatory myopathy with a variable clinical spectrum. In recent years, a number of myositis-specific antibodies have been identified including anti-MDA5, which is us eful for diagnosis, prognosis and classification of the diverse clinical forms of the disease. This antibody is associated with cutaneous ulcers, rapidly progressive interstitial lung disease, early mortality and poor prognosis, so the detection of this antibody in a suitable clinical context, raises the need for an aggressive immunosuppressive treatment...
2018: Medicina
Nathalie Berghen, Jean-Baptiste Vulsteke, Rene Westhovens, Jan Lenaerts, Ellen De Langhe
OBJECTIVES: To review the therapeutic option of Rituximab, a chimeric anti-CD20 antibody, in systemic autoimmune rheumatic diseases (SARDs) such as systemic lupus erythematosus, systemic sclerosis, primary Sjögren syndrome and idiopathic inflammatory myopathy. METHODS: A non-systematic review was conducted. RESULTS: The specific role and indication of rituximab in SARDs has been the subject of multiple trials in recent years. Evidence supports the use of rituximab in moderate-to-severe refractory systemic lupus erythematosus, diffuse skin involvement in systemic sclerosis and systemic involvement in primary Sjögren syndrome...
September 26, 2018: Acta Clinica Belgica
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Abdullah Mahmood, Mitchell Hare, Nicholas Taklalsingh, Isabel M McFarlane
Idiopathic inflammatory myopathy (IIM) is a rare autoimmune myopathy that includes polymyositis, dermatomyositis, inclusion body myositis and autoimmune necrotizing myositis. Cardiac involvement was considered a rare occurrence in IIM however, recent reports suggests that cardiac involvement is a common feature and portends poor prognosis as it is usually encountered in advanced disease. IIM leads to myocarditis with subsequent development of myocardial fibrosis, cardiac conduction system disease and cardiomyopathy resulting in both systolic and diastolic heart failure...
2018: American journal of medical case reports
Christopher A Mecoli, Jin Kyun Park, Helene Alexanderson, Malin Regardt, Merrilee Needham, Ingrid de Groot, Catherine Sarver, Ingrid E Lundberg, Beverley Shea, Marianne de Visser, Yeong Wook Song, Clifton O Bingham, Lisa Christopher-Stine
OBJECTIVE: Patient-reported outcome measures (PROM) that incorporate the patient perspective have not been well established in idiopathic inflammatory myopathies (IIM). As part of our goal to develop IIM-specific PROM, the Outcome Measures in Rheumatology (OMERACT) Myositis special interest group sought to determine which aspects of disease and its effects are important to patients and healthcare providers (HCP). METHODS: Based on a prior qualitative content analysis of focus groups, an initial list of 24 candidate domains was constructed...
September 15, 2018: Journal of Rheumatology
Buenaventura Brito Díaz, Delia Almeida González, Fadoua Gannar, M Cristo Rodríguez Pérez, Antonio Cabrera de León
Myokines are peptides produced and released by myocytes of muscle fibers that influence physiology of muscle and other organs and tissues. They are involved in mediating the beneficial effects that exercise has on health. More than one hundred have been identified and among them are IL6, myostatin, irisin, mionectin and decorin. Physical inactivity leads to an altered response of the secretion of myokines and resistance to them; this leads to a pro-inflammatory state that favors sarcopenia and fat accumulation, promoting the development of cardiovascular diseases, insulin resistance, and diabetes mellitus type 2...
September 5, 2018: Immunology Letters
Satoshi Kubo, Yasuyuki Todoroki, Shingo Nakayamada, Kazuhisa Nakano, Minoru Satoh, Aya Nawata, Yurie Satoh, Ippei Miyagawa, Kazuyoshi Saito, Vanessa Smith, Maurizio Cutolo, Yoshiya Tanaka
Objective: The aim of this study was to investigate the clinical and immunological significance of nailfold videocapillaroscopy (NVC) abnormalities in patients with idiopathic inflammatory myopathies (IIMs). Methods: Seventy consecutive Japanese patients with untreated IIMs, enrolled between April 2014 and August 2017, were prospectively studied. Clinical features, NVC findings, autoantibody profile by immunoprecipitation and ELISA, and histopathological findings of skin biopsies of DM rash were assessed at baseline and after 1-year of immunosuppressive therapy...
August 28, 2018: Rheumatology
Karina Rotella, Milena Rodriguez Alvarez, Yair Saperstein, Manjeet S Bhamra, Su Zhaz Leon, Alekznder Feoktiztov, Isabel MFarlane
Idiopathic inflammatory myopathies are rare autoimmune disorders characterized by proximal muscle weakness, elevation of muscle enzymes, abnormal electromyogram and imaging studies revealing areas of edema and inflammation. Initial approach to inflammatory myopathies includes steroids and immunosuppressive agents, with most individuals responding satisfactorily to therapy. However, treatment-refractory myopathies prompts clinicians to use second line agents to achieve remission. In this case series, we describe three patients with refractory idiopathic inflammatory myopathies who were treated with tacrolimus (TAC) added to mycophenolate mofetil (MMF) and steroid therapy, who achieved clinical and biochemical remission...
2018: Rheumatology: Current Research
Miranda Houtman, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M Reed, Ingrid E Lundberg, Leonid Padyukov
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell infiltrates in muscle tissue. In PM, a major component of inflammatory cell infiltrates is CD8+ T cells, whereas in DM, CD4+ T cells, plasmacytoid dendritic cells, and B cells predominate. In this study, with the aim to differentiate involvement of CD4+ and CD8+ T-cell subpopulations in myositis subgroups, we investigated transcriptomic profiles of T cells from peripheral blood of patients with myositis...
August 29, 2018: Arthritis Research & Therapy
Mehrzad Hajialilo, Amir Ghorbanihaghjo, Alireza Khabbazi, Sousan Kolahi, Mohammad Reza Jafari Nakhjavani, Ali Asghar Ebrahimi, Hamid Zareh, Aida Malek Mahdavi
AIM: This study aimed to follow up patients with polymyositis (PM) and/or dermatomyositis (DM) to determine survival rate, pattern of disease, response to treatment, malignancy incidence and poor prognostic factors (PPFs). METHOD: A total of 76 patients with PM (n = 47) and/or DM (n = 29) based on Bohan and Peter diagnostic criteria referred to the Imam-Reza Hospital were followed up from 2004 to 2016. The follow-up period was considered from diagnosis to patient's death or last visit...
August 2018: International Journal of Rheumatic Diseases
Qing-Lin Peng, Jin-Ming Lin, Yong-Biao Zhang, Xue-Zhi Zhang, Pan-Pan Wang, Ting-Ting Wu, Jun Yu, Xiao-Qun Dong, Ming-Liang Gu, Guo-Chun Wang
OBJECTIVES: Previous association studies have identified genetic variants in the human leukocyte antigen (HLA) complex as substantial risk factors for idiopathic inflammatory myopathies (IIMs). However, a great number of genes are located in the HLA region, and thus fine mapping is quite necessary. METHODS: Targeted capture sequencing were performed on the whole HLA region in 42 IIM patients and 24 healthy controls. A microarray analysis was applied to analyze gene expression profiles in additional 20 newly diagnosed IIM and five healthy controls...
August 2018: International Journal of Rheumatic Diseases
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