Laure Campillo-Gimenez, Félix Renaudin, Maud Jalabert, Pierre Gras, Marjolaine Gosset, Christian Rey, Stéphanie Sarda, Corinne Collet, Martine Cohen-Solal, Christèle Combes, Frédéric Lioté, Hang-Korng Ea
Background: Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide clinical phenotypes, including acute and chronic arthritis, that are interleukin 1β (IL-1β)-driven. Two CPP microcrystals, namely monoclinic and triclinic CPP dihydrates (m- and t-CPPD), have been identified in human tissues in different proportions according to clinical features. m-CPP tetrahydrate beta (m-CPPTβ) and amorphous CPP (a-CPP) phases are considered as m- and t-CPPD crystal precursors in vitro . Objectives: We aimed to decipher the inflammatory properties of the three crystalline phases and one amorphous CPP phase and the intracellular pathways involved...
2018: Frontiers in Immunology