keyword
https://read.qxmd.com/read/38388163/a-model-based-approach-to-estimating-the-prevalence-of-disease-combinations-in-south-africa
#1
JOURNAL ARTICLE
Leigh F Johnson, Reshma Kassanjee, Naomi Folb, Sarah Bennett, Andrew Boulle, Naomi S Levitt, Robyn Curran, Kirsty Bobrow, Rifqah A Roomaney, Max O Bachmann, Lara R Fairall
BACKGROUND: The development of strategies to better detect and manage patients with multiple long-term conditions requires estimates of the most prevalent condition combinations. However, standard meta-analysis tools are not well suited to synthesising heterogeneous multimorbidity data. METHODS: We developed a statistical model to synthesise data on associations between diseases and nationally representative prevalence estimates and applied the model to South Africa...
February 22, 2024: BMJ Global Health
https://read.qxmd.com/read/38381724/hiv-multimorbidity-and-health-related-quality-of-life-in-rural-kwazulu-natal-south-africa-a-population-based-study
#2
JOURNAL ARTICLE
Amelia M Stanton, Ryan L Boyd, Conall O'Cleirigh, Stephen Olivier, Brett Dolotina, Resign Gunda, Olivier Koole, Dickman Gareta, Tshwaraganang H Modise, Zahra Reynolds, Thandeka Khoza, Kobus Herbst, Thumbi Ndung'u, Willem A Hanekom, Emily B Wong, Deenan Pillay, Mark J Siedner
Health-related quality of life (HRQoL) assesses the perceived impact of health status across life domains. Although research has explored the relationship between specific conditions, including HIV, and HRQoL in low-resource settings, less attention has been paid to the association between multimorbidity and HRQoL. In a secondary analysis of cross-sectional data from the Vukuzazi ("Wake up and know ourselves" in isiZulu) study, which identified the prevalence and overlap of non-communicable and infectious diseases in the uMkhanyakunde district of KwaZulu-Natal, we (1) evaluated the impact of multimorbidity on HRQoL; (2) determined the relative associations among infectious diseases, non-communicable diseases (NCDs), and HRQoL; and (3) examined the effects of controlled versus non-controlled disease on HRQoL...
2024: PloS One
https://read.qxmd.com/read/38281250/syndemic-of-substance-abuse-depression-and-type-2-diabetes-and-their-association-with-retention-in-care-among-people-living-with-hiv
#3
JOURNAL ARTICLE
Tarek B Eshak, Andrea L Hobkirk, Cynthia J Whitener, Liza M Conyers, Wenke Hwang, Kristin K Sznajder
Substance abuse (SA), depression, and type 2 diabetes (DM2) often co-occur among people living with HIV (PLHIV). Guided by a syndemic framework, this cross-sectional retrospective study examined the cumulative and interaction effects of SA, depression, and DM2 on retention in HIV care (RIC) among 621 PLHIV receiving medical care in central Pennsylvania. We performed logistic regression analysis to test the associations between SA, depression, and DM2 and RIC. To test the "syndemic" model, we assessed additive and multiplicative interactions...
January 28, 2024: AIDS and Behavior
https://read.qxmd.com/read/38236326/risk-factors-for-herpes-zoster-infections-a-systematic-review-and-meta-analysis-unveiling-common-trends-and-heterogeneity-patterns
#4
JOURNAL ARTICLE
Maren Steinmann, David Lampe, John Grosser, Juliana Schmidt, Marla Louise Hohoff, Anita Fischer, Wolfgang Greiner
PURPOSE: The burden of herpes zoster (HZ) is substantial and numerous chronic underlying conditions are known as predisposing risk factors for HZ onset. Thus, a comprehensive study is needed to synthesize existing evidence. This study aims to comprehensively identify these risk factors. METHODS: A systematic literature search was done using MEDLINE via PubMed, EMBASE and Web of Science for studies published from January 1, 2003 to January 1, 2023. A random-effects model was used to estimate pooled Odds Ratios (OR)...
January 18, 2024: Infection
https://read.qxmd.com/read/38215160/the-forecasted-prevalence-of-comorbidities-and-multimorbidity-in-people-with-hiv-in-the-united-states-through-the-year-2030-a-modeling-study
#5
JOURNAL ARTICLE
Keri N Althoff, Cameron Stewart, Elizabeth Humes, Lucas Gerace, Cynthia Boyd, Kelly Gebo, Amy C Justice, Emily P Hyle, Sally B Coburn, Raynell Lang, Michael J Silverberg, Michael A Horberg, Viviane D Lima, M John Gill, Maile Karris, Peter F Rebeiro, Jennifer Thorne, Ashleigh J Rich, Heidi Crane, Mari Kitahata, Anna Rubtsova, Cherise Wong, Sean Leng, Vincent C Marconi, Gypsyamber D'Souza, Hyang Nina Kim, Sonia Napravnik, Kathleen McGinnis, Gregory D Kirk, Timothy R Sterling, Richard D Moore, Parastu Kasaie
BACKGROUND: Estimating the medical complexity of people aging with HIV can inform clinical programs and policy to meet future healthcare needs. The objective of our study was to forecast the prevalence of comorbidities and multimorbidity among people with HIV (PWH) using antiretroviral therapy (ART) in the United States (US) through 2030. METHODS AND FINDINGS: Using the PEARL model-an agent-based simulation of PWH who have initiated ART in the US-the prevalence of anxiety, depression, stage ≥3 chronic kidney disease (CKD), dyslipidemia, diabetes, hypertension, cancer, end-stage liver disease (ESLD), myocardial infarction (MI), and multimorbidity (≥2 mental or physical comorbidities, other than HIV) were forecasted through 2030...
January 12, 2024: PLoS Medicine
https://read.qxmd.com/read/38100401/mapping-evidence-on-barriers-to-and-facilitators-of-diagnosing-noncommunicable-diseases-ncds-among-people-living-with-human-immunodeficiency-virus-plwh-in-low-and-middle-income-countries-lmics-in-africa-a-scoping-review-protocol
#6
JOURNAL ARTICLE
Abebe Sorsa Badacho, Ozayr Harron Mahomed
BACKGROUND: Noncommunicable diseases (NCDs) represent a global public health challenge in all population groups, but the prevalence of major NCDs, such as depression, hypercholesterolemia, hypertension, obesity and diabetes, is increasing at a rapid rate among people living with human immunodeficiency virus (PLWH). Studies show that integrated NCDs and human immunodeficiency virus (HIV) services have improved the patient outcome of PLWH with comorbidities with NCDs. It requires a strengthened and sustainable way of diagnosing major NCDs early among PLWH...
2023: PloS One
https://read.qxmd.com/read/38081957/health-effects-associated-with-exposure-to-intimate-partner-violence-against-women-and-childhood-sexual-abuse-a-burden-of-proof-study
#7
JOURNAL ARTICLE
Cory N Spencer, Mariam Khalil, Molly Herbert, Aleksandr Y Aravkin, Alejandra Arrieta, María Jose Baeza, Flavia Bustreo, Jack Cagney, Renzo J C Calderon-Anyosa, Sinclair Carr, Jaidev Kaur Chandan, Carolina V N Coll, Fabiana Martins Dias de Andrade, Gisele N de Andrade, Alexandra N Debure, Luisa S Flor, Ben Hammond, Simon I Hay, Felicia N Knaul, Rachel Q H Lim, Susan A McLaughlin, Sonica Minhas, Jasleen K Mohr, Erin C Mullany, Christopher J L Murray, Erin M O'Connell, Vedavati Patwardhan, Sofia Reinach, Dalton Scott, Reed J D Sorenson, Caroline Stein, Heidi Stöckl, Aisha Twalibu, Nádia Vasconcelos, Peng Zheng, Nicholas Metheny, Joht Singh Chandan, Emmanuela Gakidou
The health impacts of intimate partner violence against women and childhood sexual abuse are not fully understood. Here we conducted a systematic review by comprehensively searching seven electronic databases for literature on intimate partner violence-associated and childhood sexual abuse-associated health effects. Following the burden of proof methodology, we evaluated the evidence strength linking intimate partner violence and/or childhood sexual abuse to health outcomes supported by at least three studies...
December 2023: Nature Medicine
https://read.qxmd.com/read/38029949/the-association-of-prescribed-opioids-and-incident-cardiovascular-disease
#8
JOURNAL ARTICLE
Minhee L Sung, Svetlana K Eden, William C Becker, Stephen Crystal, Meredith S Duncan, Kirsha S Gordon, Robert D Kerns, Suman Kundu, Matthew Freiberg, Kaku A So-Armah, E Jennifer Edelman
Opioid prescribing remains common despite known overdose-related harms. Less is known about links to nonoverdose morbidity. We determined the association between prescribed opioid receipt with incident cardiovascular disease (CVD) using data from the Veterans Aging Cohort Study, a national prospective cohort of Veterans with/without Human Immunodeficiency Virus (HIV) receiving Veterans Health Administration care. Selected participants had no/minimal prior exposure to prescription opioids, no opioid use disorder, and no severe illness 1 year after the study start date (baseline period)...
November 27, 2023: Journal of Pain
https://read.qxmd.com/read/37963101/interventions-for-improving-health-literacy-in-migrants
#9
REVIEW
Annika Baumeister, Angela Aldin, Digo Chakraverty, Constanze Hübner, Anne Adams, Ina Monsef, Nicole Skoetz, Elke Kalbe, Christiane Woopen
BACKGROUND: Health literacy (HL) is a determinant of health and important for autonomous decision-making. Migrants are at high risk for limited HL. Improving HL is important for equitable promotion of migrants' health. OBJECTIVES: To assess the effectiveness of interventions for improving HL in migrants. To assess whether female or male migrants respond differently to the identified interventions. SEARCH METHODS: We ran electronic searches to 2 February 2022 in CENTRAL, MEDLINE, Embase, PsycInfo and CINAHL...
November 14, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37894084/hiv-and-an-ageing-population-what-are-the-medical-psychosocial-and-palliative-care-challenges-in-healthcare-provisions
#10
REVIEW
Mohamed H Ahmed, Fatima Ahmed, Abu-Bakr Abu-Median, Maria Panourgia, Henry Owles, Bertha Ochieng, Hassan Ahamed, Jane Wale, Benjamin Dietsch, Dushyant Mital
The continuing increase in patient numbers and improvement in healthcare provisions of HIV services in the UK, alongside the effectiveness of combined antiretroviral therapy (cART), has resulted in increasing numbers of the ageing population among people living with HIV (PLWH). It is expected that geriatricians will need to deal with many older people living with HIV (OPLWH) as life expectancy increases. Therefore, geriatric syndromes in OPLWH will be similar to the normal population, such as falls, cognitive decline, frailty, dementia, hypertension, diabetes and polypharmacy...
September 28, 2023: Microorganisms
https://read.qxmd.com/read/37842552/the-burden-of-non-communicable-diseases-among-people-living-with-hiv-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Maureen Moyo-Chilufya, Kuhlula Maluleke, Kabelo Kgarosi, Monde Muyoyeta, Charles Hongoro, Alfred Musekiwa
BACKGROUND: Non-communicable diseases (NCDs) are increasing among people living with HIV (PLHIV), especially in Sub-Saharan Africa (SSA). We determined the prevalence of NCDs and NCD risk factors among PLHIV in SSA to inform health policy makers. METHODS: We conducted a systematic review and meta-analysis on the prevalence of NCDs and risk factors among PLHIV in SSA. We comprehensively searched PubMed/MEDLINE, Scopus, and EBSCOhost (CINAHL) electronic databases for sources published from 2010 to July 2023...
November 2023: EClinicalMedicine
https://read.qxmd.com/read/37625185/study-protocol-using-cohort-data-and-latent-variable-modeling-to-guide-sampling-women-with-type-2-diabetes-and-depressive-symptoms
#12
JOURNAL ARTICLE
Nicole Beaulieu Perez, Gail D'Eramo Melkus, Gary Yu, Janet Brown-Friday, Kathryn Anastos, Brad Aouizerat
BACKGROUND: Depression affects one in three women with Type 2 diabetes, and this concurrence significantly increases the risks of diabetes complications, disability, and early mortality. Depression is underrecognized because of wide variation in presentation and the lack of diagnostic biomarkers. Converging evidence suggests inflammation is a shared biological pathway in diabetes and depression. Overlapping epigenetic associations and social determinants of diabetes and depression implicate inflammatory pathways as a common thread...
September 2023: Nursing Research
https://read.qxmd.com/read/37523187/prevalence-of-12-common-health-conditions-in-sexual-and-gender-minority-participants-in-the-all-of-us-research-program
#13
JOURNAL ARTICLE
Nguyen K Tran, Mitchell R Lunn, Claire E Schulkey, Samantha Tesfaye, Siddhartha Nambiar, Snigdhansu Chatterjee, Dawn Kozlowski, Paula Lozano, Fornessa T Randal, Yicklun Mo, Siya Qi, Ell Hundertmark, Chloe Eastburn, Anthony T Pho, Zubin Dastur, Micah E Lubensky, Annesa Flentje, Juno Obedin-Maliver
IMPORTANCE: Limited data describe the health status of sexual or gender minority (SGM) people due to inaccurate and inconsistent ascertainment of gender identity, sex assigned at birth, and sexual orientation. OBJECTIVE: To evaluate whether the prevalence of 12 health conditions is higher among SGM adults in the All of Us Research Program data compared with cisgender heterosexual (non-SGM) people. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from a multidisciplinary research consortium, the All of Us Research Program, that links participant-reported survey information to electronic health records (EHR) and physical measurements...
July 3, 2023: JAMA Network Open
https://read.qxmd.com/read/37346348/recent-medicinal-approaches-of-novel-pyrimidine-analogs-a-review
#14
REVIEW
Sharanabasappa B Patil
Pyrimidine derivatives attract researchers due to their versatile scaffold & their medicinal significance. Pyrimidine associated analogs are majorly contributed to the field of medicinal chemistry. In this review article, the recent new structural design and development of active agent studies and biological approaches are highlighted. In addition, the biological potency and the structure-activity relationship of pyrimidines such as antimicrobial, anticancer, anti-inflammatory, analgesic, anti-diabetic, anti-HIV, anthelmintic, CNS depressants, and cardiac agents are discussed...
June 2023: Heliyon
https://read.qxmd.com/read/37336537/estimate-of-the-prevalence-of-subjects-with-chronic-diseases-in-a-province-of-northern-italy-a-retrospective-study-based-on-administrative-databases
#15
JOURNAL ARTICLE
Chiara Airoldi, Federico Pagnoni, Tiziana Cena, Daniele Ceriotti, Damiano De Ambrosi, Marta De Vito, Fabrizio Faggiano
OBJECTIVE: To find a definition of chronic disease based on literature review and to estimate the population-based prevalence rate of chronicity in a province in Northern Italy. DESIGN: Retrospective observational study based on administrative databases. DATA SOURCES/SETTING: Archives of the National Health Service that contain demographic and administrative information linked with the archives of ticket exemptions (2000-2019), the hospital discharge and drug prescriptions (2016-2019)...
June 19, 2023: BMJ Open
https://read.qxmd.com/read/37325955/androgens-and-selective-androgen-receptor-modulators-to-treat-functional-limitations-associated-with-aging-and-chronic-disease
#16
REVIEW
Shalender Bhasin, Venkatesh Krishnan, Thomas W Storer, Mitchell Steiner, Adrian S Dobs
Testosterone, many steroidal androgens, and nonsteroidal ligands that bind to androgen receptor and exert tissue-specific transcriptional activity (selective androgen receptor modulators [SARMs]) are being developed as function-promoting therapies to treat functional limitations associated with aging and chronic diseases. This narrative review describes preclinical studies, mechanisms, and randomized trials of testosterone, other androgens, and nonsteroidal SARMs. Sex differences in muscle mass and strength and empiric use of anabolic steroids by athletes to increase muscularity and athletic performance provide supportive evidence of testosterone's anabolic effects...
June 16, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/37325316/association-between-depression-and-hiv-infection-vulnerable-populations-in-united-states-adults-a-cross-sectional-analysis-of-nhanes-from-1999-to-2018
#17
JOURNAL ARTICLE
Yan Xu, Yuexin Huang, Jie Peng, Ruiti Tang, Bin Luo, Zhiwei Xia
BACKGROUND: Although the government has made a commitment to advance education on HIV disclosure, depression continues to play a significant role in whether people living with HIV (PLWH) choose to disclose their HIV status to families or friends. Vulnerable populations who are at risk of contracting HIV may also be more susceptible to mental illness. However, there is a limited understanding of the association between depression and vulnerable populations affects by HIV among United States adults...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37276199/an-assessment-of-hiv-risk-perceptions-of-risk-and-potential-adherence-to-preexposure-prophylaxis-among-hiv-negative-people-with-injection-drug-use-who-access-mobile-outreach-services
#18
JOURNAL ARTICLE
Jane Dimmitt Champion, Pam Recto
OBJECTIVE: The purpose of this study was to assess HIV risk, perceptions of risk, and potential adherence to preexposure prophylaxis (PrEP) for the prevention of HIV infection among people who inject drugs (PWID), who self-report HIV negative status and access mobile outreach intravenous drug use (IVDU) services. METHODS/SAMPLE: Participants (N = 93) were non-Hispanic White (59.1%) and Hispanic (36.6%), between the ages of 18 and 63 years, primarily male (58.1%), who reported a length of IVDU between 1 and >20 years and accessed mobile outreach IVDU services in a metropolitan area of the Southwestern United States; all self-reported HIV-negative status...
April 2023: Journal of Addictions Nursing
https://read.qxmd.com/read/37191342/study-protocol-using-cohort-data-and-latent-variable-modeling-to-guide-sampling-women-with-type-2-diabetes-and-depressive-symptoms
#19
JOURNAL ARTICLE
Nicole Beaulieu Perez, Gail D'Eramo Melkus, Gary Yu, Janet Brown-Friday, Kathryn Anastos, Brad Aouizerat
BACKGROUND: Depression affects one in three women with type 2 diabetes, and this concurrence significantly increases the risks of diabetes complications, disability, and early mortality. Depression is underrecognized due to wide variation in presentation and the lack of diagnostic biomarkers. Converging evidence suggests inflammation is a shared biological pathway in diabetes and depression. Overlapping epigenetic associations and social determinants of diabetes and depression implicate inflammatory pathways as a common thread...
May 12, 2023: Nursing Research
https://read.qxmd.com/read/37058293/estimated-use-of-prescription-medications-among-individuals-incarcerated-in-jails-and-state-prisons-in-the-us
#20
JOURNAL ARTICLE
Jill Curran, Brendan Saloner, Tyler N A Winkelman, G Caleb Alexander
IMPORTANCE: Although incarcerated individuals experience higher rates of chronic conditions, little is known regarding the use of prescription medications in jails and prisons in the US. OBJECTIVE: To characterize treatment with prescription medications in jails and state prisons relative to noncorrectional settings in the US. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional analysis using 2018 to 2020 data from the National Survey on Drug Use and Health (NSDUH) estimated the prevalence of disease among recently incarcerated and nonincarcerated adults in the US...
April 7, 2023: JAMA health forum
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