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https://www.readbyqxmd.com/read/29960014/chronic-depression-symptoms-desensitize-renin-activity-to-protect-against-volume-loading-hypertension-in-blacks-the-sabpa-study
#1
Arnoldeen C De Vos, Leone Malan, Yackoob K Seedat, Marike Cockeran, Nicolaas T Malan
BACKGROUND: Low-renin levels in Blacks have been associated with volume-loading hypertension (HT). Depressive symptoms, frequently co-occurring with vascular dysregulation, might reflect a disturbed renin-angiotensin-aldosterone-system (RAAS). We aimed to assess prospective changes (∆) in depression symptoms, RAAS (renin, aldosterone), diastolic blood pressure (DBP), and estimated glomerular filtration rate (eGFR) in a bi-ethnic sex cohort. METHODS: We included 195 Black and White teachers (43...
June 27, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29952792/from-hiv-prevention-to-non-communicable-disease-health-promotion-efforts-in-sub-saharan-africa-a-narrative-review
#2
Kenneth Juma, Michael Reid, Monika Roy, Susan Vorkoper, Tecla M Temu, Naomi S Levitt, Oladimeji Oladepo, David Zakus, Gerald Yonga
OBJECTIVE: To synthesize published literature on noncommunicable disease (NCD) behavior change communication (BCC) interventions in sub-Saharan Africa (SSA) among persons living with HIV (PLHIV) and in the general population to inform efforts to adopt similar HIV and NCD BCC intervention activities. METHODS: We conducted a literature review of NCD BCC interventions and included 20 SSA-based studies. Inclusion criteria entailed describing a BCC intervention targeting any four priority NCDs (cardiovascular disease, type 2 diabetes, cervical cancer, and depression) or both HIV and any of the NCDs...
July 1, 2018: AIDS
https://www.readbyqxmd.com/read/29952786/noncommunicable-diseases-among-hiv-infected-persons-in-low-income-and-middle-income-countries-a-systematic-review-and-meta-analysis
#3
Pragna Patel, Charles E Rose, Pamela Y Collins, Bernardo Nuche-Berenguer, Vikrant V Sahasrabuddhe, Emmanuel Peprah, Susan Vorkoper, Sonak D Pastakia, Dianne Rausch, Naomi S Levitt
OBJECTIVE: To appropriately identify and treat noncommunicable diseases (NCDs) among persons living with HIV (PLHIV) in low-and-middle-income countries (LMICs), it is imperative to understand the burden of NCDs among PLHIV in LMICs and the current management of the diseases. DESIGN: Systematic review and meta-analysis. METHODS: We examined peer-reviewed literature published between 1 January 2010 and 31 December 2016 to assess currently available evidence regarding HIV and four selected NCDs (cardiovascular disease, cervical cancer, depression, and diabetes) in LMICs with a focus on sub-Saharan Africa...
July 1, 2018: AIDS
https://www.readbyqxmd.com/read/29939214/depressive-symptoms-and-their-relation-to-age-and-chronic-diseases-among-middle-aged-and-older-adults-in-rural-south-africa
#4
Pascal Geldsetzer, Maria Vaikath, Ryan Wagner, Julia K Rohr, Livia Montana, Francesc X Gómez-Olivé, Molly S Rosenberg, Jennifer Manne-Goehler, Farrah J Mateen, Collin F Payne, Kathleen Kahn, Stephen M Tollman, Joshua A Salomon, Thomas A Gaziano, Till Bärnighausen, Lisa F Berkman
Background: Understanding how depression is associated with chronic conditions and socio-demographic characteristics can inform the design and effective targeting of depression screening and care interventions. In this study, we present some of the first evidence from sub-Saharan Africa on the association between depressive symptoms and a range of chronic conditions (diabetes, HIV, hypertension, and obesity) as well as socio-demographic characteristics. Methods: A questionnaire was administered to a population-based simple random sample of 5,059 adults aged 40 years in Agincourt, South Africa...
June 22, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29927346/the-effect-of-medical-technology-innovations-on-patient-outcomes-1990-2015-results-of-a-physician-survey
#5
David E Wamble, Michael Ciarametaro, Robert Dubois
BACKGROUND: Developments in diagnostics, medical devices, procedures, and prescription drugs have increased life expectancy and quality of life after diagnosis for many diseases. Previous research has shown that, overall, increased investment in medical technology has led to increased health outcomes. In addition, the value of investment in specific innovations, particularly in new pharmaceuticals or biopharmaceuticals, has frequently been shown through an evaluation of the associated health outcomes and costs...
June 21, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29851265/real-world-effectiveness-of-elbasvir-grazoprevir-in-hcv-infected-patients-in-the-us-veterans-affairs-healthcare-system
#6
J R Kramer, A Puenpatom, K F Erickson, Y Cao, D Smith, H B El-Serag, F Kanwal
Elbasvir/grazoprevir (EBR/GZR) is an all-oral direct-acting antiviral agent (DAA) with high sustained virologic response (SVR) in clinical trials. This study's primary objective was to evaluate effectiveness of EBR/GZR among HCV-infected patients in a real-world clinical setting. We conducted a nationwide retrospective observational cohort study of HCV-infected patients in the US Department of Veterans Affairs (VA) using the VA Corporate Data Warehouse. The study population included patients with positive HCV RNA who initiated EBR/GZR from February 1 to August 1, 2016...
May 31, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29807146/stroke-cerebrovascular-diseases-and-vascular-cognitive-impairment-in-africa
#7
REVIEW
Rufus O Akinyemi, Mayowa O Owolabi, Masafumi Ihara, Albertino Damasceno, Adesola Ogunniyi, Catherine Dotchin, Stella-Maria Paddick, Julius Ogeng'o, Richard Walker, Raj N Kalaria
With increased numbers of older people a higher burden of neurological disorders worldwide is predicted. Stroke and other cerebrovascular diseases do not necessarily present with different phenotypes in Africa but their incidence is rising in tandem with the demographic change in the population. Age remains the strongest irreversible risk factor for stroke and cognitive impairment. Modifiable factors relating to vascular disease risk, diet, lifestyle, physical activity and psychosocial status play a key role in shaping the current spate of stroke related diseases in Africa...
May 25, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29771779/cost-of-integrating-non-communicable-disease-screening-into-home-based-hiv-testing-and-counseling-in-south-africa
#8
Ilya Golovaty, Monisha Sharma, Alastair Van Heerden, Heidi van Rooyen, Jared M Baeten, Connie Celum, Ruanne V Barnabas
INTRODUCTION: Integrated HIV-non-communicable disease (NCD) services have the potential to avert death and disability, but require data on program costs to assess the impact of integrated services on affordability. METHODS: We estimated the incremental costs of NCD screening as part of home-based HIV testing and counseling (HTC) and referral to care in KwaZulu-Natal, South Africa. All adults in the households were offered integrated HIV-NCD screening (for HIV, diabetes, hypertension, hypercholesterolemia, obesity, depression, tobacco and alcohol use), counseling, and linkage to care...
May 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29733939/ethnic-differences-and-comorbidities-of-909-prurigo-nodularis-patients
#9
Emily Boozalis, Olive Tang, Shivani Patel, Yevgeniy R Semenov, Manuel P Pereira, Sonja Stander, Sewon Kang, Shawn G Kwatra
BACKGROUND: Prurigo Nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life. OBJECTIVE: To characterize the demographics and comorbidities associated with PN. METHODS: Cross-sectional study of patients ≥ 18 years old seen at the Johns Hopkins Health System (JHHS) between 12/6/2012-12/6/2017. RESULTS: Over the last five years, 909 patients with PN were seen at JHHS. African-American patients were 3...
May 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29561173/evaluation-of-statin-eligibility-prescribing-practices-and-therapeutic-responses-using-atp-iii-acc-aha-and-nla-dyslipidemia-treatment-guidelines-in-a-large-urban-cohort-of-hiv-infected-outpatients
#10
Matthew E Levy, Alan E Greenberg, Manya Magnus, Naji Younes, Amanda Castel
Statin coverage has been examined among HIV-infected patients using Adult Treatment Panel III (ATP III) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines, although not with newer National Lipid Association (NLA) guidelines. We investigated statin eligibility, prescribing practices, and therapeutic responses using these three guidelines. Sociodemographic, clinical, and laboratory data were collected between 2011 and 2016 for HIV-infected outpatients enrolled in the DC Cohort, a multi-center, prospective, observational study in Washington, DC...
February 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29548302/comparing-dedicated-and-designated-models-of-integrating-mental-health-into-chronic-disease-care-study-protocol-for-a-cluster-randomized-controlled-trial
#11
Bronwyn Myers, Crick Lund, Carl Lombard, John Joska, Naomi Levitt, Christopher Butler, Susan Cleary, Tracey Naledi, Peter Milligan, Dan J Stein, Katherine Sorsdahl
BACKGROUND: In low- and middle-income countries (LMIC), it is uncertain whether a "dedicated" approach to integrating mental health care (wherein a community health worker (CHW) has the sole responsibility of delivering mental health care) or a "designated" approach (wherein a CHW provides this service in addition to usual responsibilities) is most effective and cost-effective. This study aims to compare the effectiveness and cost-effectiveness of these two models of service integration relative to treatment as usual (TAU) for improving mental health and chronic disease outcomes among patients with HIV or diabetes...
March 16, 2018: Trials
https://www.readbyqxmd.com/read/29435953/role-of-noncommunicable-diseases-ncds-in-resource-limited-settings-rls
#12
REVIEW
Mosepele Mosepele, Elizabeth Botsile
PURPOSE OF REVIEW: As access to effective antiretroviral therapy (ART) expands globally, a decline in AIDS-related morbidity and mortality has been complicated by rising rates of noncommunicable diseases (NCDs). This review provides a brief description of NCDs and existing gaps on knowledge about NCDs among HIV-infected adults mostly in Africa. RECENT FINDINGS: Recent reports show that one in every five persons living with HIV has a chronic illness, predominantly diabetes and/or hypertension, depression, and most of these conditions are either not diagnosed or not being managed...
April 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29430957/anxiety-depression-and-health-related-quality-of-life-in-aging-people-living-with-hiv-compared-to-diabetes-patients-and-patients-with-minor-health-conditions-a-longitudinal-study
#13
Joram Ronel, Andreas Dinkel, Eva Wolf, Birgitt Marten-Mittag, Birgit Mueck, Christoph Mayr, Christian Hoffmann, Martin Karwat, Knud Schewe, Axel Baumgarten, Hans Jaeger
HIV infection has evolved from a fatal to a treatable condition, leading to an increase in the rate of elderly People Living with HIV (PLWH). However, little is known about the psychosocial burden of elderly PLWH. Thus, the aim of this longitudinal multi-center cohort study was to investigate whether elderly PLWH experience more anxiety and depression and reduced health related quality of life (HRQOL) compared to elderly patients with other chronic conditions. PLWH were compared to diabetes patients (DM) and patients with minor health conditions (MHC), e...
February 11, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29424096/low-education-and-lack-of-spousal-relationship-are-associated-with-dementia-in-older-adults-with-diabetes-mellitus-in-nigeria
#14
Abdulkareem J Yusuf, Olusegun Baiyewu, Adamu G Bakari, Sani B Garko, Mohammed E-B Jibril, Aishatu M Suleiman, Haruna M Muktar, Micheal A Amedu
BACKGROUND: The relationship between dementia and type 2 diabetes mellitus (T2DM) in older adults is well established in the literature. However, there have been few studies on this relationship in older adults living in low- and middle-income countries, and most demographic projections predict that older adult population will increase substantially in these regions by 2050. METHODS: In this study, older adults with T2DM attending a tertiary health facility were examined and compared with community-dwelling older adults without T2DM...
May 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29383534/psychosocial-complications-of-hiv-aids-metabolic-disorder-comorbidities-among-patients-in-a-rural-area-of-southeastern-united-states
#15
Dominica Hernandez, Seth C Kalichman, Harold P Katner, Kaylee Burnham, Moira O Kalichman, Marnie Hill
As people living with HIV experience longer life-expectancies resulting from antiretroviral therapy, comorbid conditions are increasing, particularly metabolic disorders. There is potential for psychosocial factors such as stigma experiences, depression, and alcohol use to complicate both HIV infection and metabolic disorders, including diabetes mellitus and hyperlipidemia. While the impact of these psychosocial factors on HIV infection alone are widely studied, their role in potentially complicating HIV co-morbid metabolic conditions has received little attention...
January 30, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29369158/the-growing-burden-of-noncommunicable-disease-among-persons-living-with-hiv-in-zimbabwe
#16
Mikaela Smit, Jack Olney, Nathan P Ford, Marco Vitoria, Simon Gregson, Anna Vassall, Timothy B Hallett
OBJECTIVES: We aim to characterize the future noncommunicable disease (NCD) burden in Zimbabwe to identify future health system priorities. METHODS: We developed an individual-based multidisease model for Zimbabwe, simulating births, deaths, infection with HIV and progression and key NCD [asthma, chronic kidney disease (CKD), depression, diabetes, hypertension, stroke, breast, cervical, colorectal, liver, oesophageal, prostate and all other cancers]. The model was parameterized using national and regional surveillance and epidemiological data...
March 27, 2018: AIDS
https://www.readbyqxmd.com/read/29323557/neuropsychological-assessment-of-412-hiv-infected-individuals-in-s%C3%A3-o-paulo-brazil
#17
Maria Rita Polo Gascón, José Ernesto Vidal, Yolanda Marques Mazzaro, Jerusa Smid, Rosa Maria Nascimento Marcusso, Claudio Garcia Capitão, Elizeu Macedo Coutinho, Glaucia Rosana Guerra Benute, Mara Cristina Souza De Lucia, Augusto César Penalva de Oliveira
HIV-associated neurocognitive disorders (HAND) remain frequent even among individuals receiving combined antiretroviral therapy (cART). In addition, HAND may adversely affect the quality of life and adherence to cART. There is scarce epidemiological information about HAND in Latin America. This cross-sectional study recruited HIV-infected patients from a tertiary teaching institution in São Paulo, Brazil, between May 2013 and February 2015. The patients were adults with at least 4 years of education and patients with current neurological or psychiatric diseases were excluded...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29228820/associations-between-depressive-symptomatology-and-neurocognitive-impairment-in-hiv-aids
#18
Sarah Tymchuk, Daniela Gomez, Noshin Koenig, M John Gill, Esther Fujiwara, Christopher Power
OBJECTIVE: Mood disorders and neurocognitive impairments are debilitating conditions among patients with HIV/AIDS. How these comorbidities interact and their relationships to systemic factors remain uncertain. Herein, we investigated factors contributing to depressive symptomatology (DS) in a prospective cohort of patients with HIV/AIDS in active care that included neuropsychological assessment. METHODS: Among patients with HIV/AIDS receiving combination antiretroviral therapy (cART) and ongoing clinical assessments including measures of sleep, health-related quality of life (HQoL), neuropsychological testing, and mood evaluation (Patient Health Questionnaire-9 [PHQ-9]) were performed...
May 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29197403/setting-priorities-for-knowledge-translation-of-cochrane-reviews-for-health-equity-evidence-for-equity
#19
Peter Tugwell, Jennifer Petkovic, Vivian Welch, Jennifer Vincent, Zulfiqar A Bhutta, Rachel Churchill, Don deSavigny, Lawrence Mbuagbaw, Tomas Pantoja
BACKGROUND: A focus on equity in health can be seen in many global development goals and reports, research and international declarations. With the development of a relevant framework and methods, the Campbell and Cochrane Equity Methods Group has encouraged the application of an 'equity lens' to systematic reviews, and many organizations publish reviews intended to address health equity. The purpose of the Evidence for Equity (E4E) project was to conduct a priority-setting exercise and apply an equity lens by developing a knowledge translation product comprising summaries of systematic reviews from the Cochrane Library...
December 2, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29100941/impact-of-clinical-pharmacist-services-delivered-via-telemedicine-in-the-outpatient-or-ambulatory-care-setting-a-systematic-review
#20
REVIEW
Joshua D Niznik, Harvey He, Sandra L Kane-Gill
BACKGROUND: Utilization of telemedicine allows pharmacists to extend the reach of clinical interventions, connecting them with patients and providers, but the overall impact of these services is under-studied. OBJECTIVE: Identify the impact of clinical pharmacist telemedicine interventions on clinical outcomes, subsequently defined as clinical disease management, patient self-management, and adherence, in outpatient or ambulatory settings. METHODS: A literature search was conducted from database inception through May 2016 in Medline, SCOPUS, and EMBASE...
October 28, 2017: Research in Social & Administrative Pharmacy: RSAP
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