Alec A Schmaier, Papa F Anderson, Siyu M Chen, Emale El-Darzi, Ivan Aivasovsky, Milan P Kaushik, Kelsey D Sack, H Criss Hartzell, Samir M Parikh, Robert Flaumenhaft, Sol Schulman
Endothelial cells (ECs) normally form an anticoagulant surface under physiological conditions, but switch to support coagulation following pathogenic stimuli. This switch promotes thrombotic cardiovascular disease. To generate thrombin at physiologic rates, coagulation proteins assemble on a membrane containing anionic phospholipid, most notably phosphatidylserine (PS). PS can be rapidly externalized to the outer cell membrane leaflet by phospholipid "scramblases," such as TMEM16F. TMEM16F-dependent PS externalization is well characterized in platelets...
June 1, 2023: Journal of Clinical Investigation