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https://www.readbyqxmd.com/read/28213295/determination-of-imm-h004-a-novel-neuroprotective-agent-in-rat-plasma-and-brain-tissue-by-liquid-chromatography-tandem-mass-spectrometry
#1
Ziqian Zhang, Xiangmeng Wu, Manman Zhao, Yakun Yang, Yan Wang, Jinping Hu, Baolian Wang, Li Sheng, Yan Li
A rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of IMM-H004, a novel neuroprotective agent, in rat plasma and brain was developed. Plasma and brain tissue homogenate samples containing IMM-H004 and propranolol (internal standard, IS) were prepared by using a direct protein precipitation of acetonitrile. Separation was carried out in Zorbax SB-C18 column at a flow rate of 0.3mL/min utilizing acetonitrile/water as mobile phases which contain 0.5% formic acid (v/v)...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28213230/the-pentafluorophenyl-stationary-phase-shows-a-unique-separation-efficiency-for-performing-fast-chromatography-determination-of-highbush-blueberry-anthocyanins
#2
Barbora Šmídová, Dalibor Šatínský, Kateřina Dostálová, Petr Solich
A high-performance liquid chromatography method using an alternative pentafluorophenyl (PFP) core-shell stationary phase has been developed and used for rapid separation of 23 anthocyanins in a highbush blueberry Bluehaven cultivar. A high efficiency of separation of anthocyanins was achieved in the core-shell column Kinetex PFP, 150×4.6mm (particle size 2.6µm) with a 5×4.6mm precolumn, using a simple linear gradient elution with a mobile phase of acetonitrile and a water solution of 2% formic acid at a flow rate of 1...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213176/lc-ms-ms-assay-for-the-simultaneous-quantitation-of-the-atm-inhibitor-az31-and-the-atr-inhibitor-azd6738-in-mouse-plasma
#3
Brian F Kiesel, Jeffrey C Shogan, Madani Rachid, Robert A Parise, Frank P Vendetti, Christopher J Bakkenist, Jan H Beumer
The ATM kinase inhibitor AZ31 and ATR kinase inhibitor AZD6738 are in various phases of preclinical and clinical evaluation for their ability to potentiate chemoradiation. To support the preclinical evaluation of their pharmacokinetics, we developed and validated an LC-MS/MS assay for the simultaneous quantification of AZ31 and AZD6738 in mouse plasma. A "dilute and shoot" method was used to precipitate proteins from a sample volume of 50μL. Chromatographic separation was achieved using a Phenomenex Polar-RP column and a gradient mobile phase consisting of methanol-water with 0...
February 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28207286/lc-ms-ms-simultaneous-analysis-of-allopregnanolone-epiallopregnanolone-pregnanolone-dehydroepiandrosterone-and-dehydroepiandrosterone-3-sulfate-in-human-plasma
#4
Luana Lionetto, Fernando De Andrés, Matilde Capi, Martina Curto, Donata Sabato, Maurizio Simmaco, Paola Bossù, Eleonora Sacchinelli, Maria Donata Orfei, Federica Piras, Nerisa Banaj, Gianfranco Spalletta
AIM: Several neuropsychopharmacological properties have been attributed to the 3α-reduced pregnane steroids, allopregnanolone and pregnanolone, as well as to dehydroepiandrosterone sulfate because of their ability to modulate γ-aminobutyric acid (GABAA) receptors in the CNS. In order to understand better their role in several mechanisms in CNS, a new methodology is proposed to monitor these compounds in human plasma. Methodology & results: The analytes were first derivatized with 2-hydrazinopyridine and extracted from plasma using SPE...
February 16, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28206761/molecular-cobalt-complexes-with-pendant-amines-for-selective-electrocatalytic-reduction-of-carbon-dioxide-to-formic-acid
#5
Souvik Roy, Bhaskar Sharma, Jacques Pecaut, Philippe Simon, Marc Fontecave, Phong D Tran, Etienne Derat, Vincent Artero
We report here on a new series of CO2-reducing molecular catalysts based on Earth-abundant elements that are very selective for the production of acid formic in DMF/water mixtures (Faradaic efficiency of 90±10%) at moderate overpotentials (500-700 mV in DMF measured at the middle of the catalytic wave). The [CpCo(PR2NR'2)I]+compounds contain diphosphine ligands PR2NR'2 with two pendent amine residues that act as proton relays during CO2 reduction catalysis and tune their activity. Four different PR2NR'2 ligands with cyclohexyl or phenyl substituents on phosphorus and benzyl or phenyl substituents on nitrogen were employed and the compound with the most electron-donating phosphine ligand and the most basic amine functions performs best among the series with turnover frequency >1000 s 1...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28205294/simultaneous-determination-of-the-bioactive-components-in-rat-plasma-by-uplc-ms-ms-and-application-in-pharmacokinetic-studies-after-oral-administration-of-radix-scutellariae-extract
#6
Jin-Hua Tao, Jun Xu, Shu Jiang, Yong Ling, Dong-Geng Wang
A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of the four main bioactive compounds, i.e., baicalin, baicalein, wogonoside and wogonin in rat plasma after oral administration of Radix scutellariae extract. Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100 mm × 2...
February 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28205290/development-and-qualification-of-an-lc-ms-ms-method-for-investigating-the-biological-implications-of-micelle-entrapped-paclitaxel-in-cell-culture-and-rats
#7
Amal Kaddoumi, Kanwaldeep K Gill, Khaled Elfakhri, Sami Nazzal
Paclitaxel is a front-line antineoplastic drug used in chemotherapeutic modalities for treatment of various types of malignancies. However, its efficacy is limited by dose related toxicities. In this study, we have explored two important biological aspects of entrapping paclitaxel in PEG2000 -DSPE micelles. First, we evaluated the impact of this micellar delivery system on P-glycoprotein (P-gp)-paclitaxel interaction, and we investigated differences in plasma pharmacokinetics of free and micelle entrapped paclitaxel...
February 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28199945/contribution-of-methane-sulfonic-acid-to-new-particle-formation-in-the-atmosphere
#8
Hailiang Zhao, Xiaotong Jiang, Lin Du
Methane sulfonic acid (MSA) is present in substantial concentrations in the gas phase over oceans and coastal regions. We present an investigation into the contribution of MSA to new particle formation with the common atmospheric aerosol nucleation precursors including MSA, methanol, formic acid, acetone, dimethylether, formaldehyde, methyl formate, by making use a quantum chemical approach. Density functional theory calculations indicate that these bimolecular complexes are characterized by the presence of strong inter-molecular hydrogen bonds (SOH⋯O) with large binding energies and thermodynamic equilibrium constants...
February 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28197561/selective-hydrogenolysis-of-carbon-oxygen-bonds-with-formic-acid-over-a-au-pt-alloy-catalyst
#9
Liang Wang, Jian Zhang, Guoxiong Wang, Wei Zhang, Chengtao Wang, Chaoqun Bian, Feng-Shou Xiao
We reported selective hydrogenolysis of carbon-oxygen species over a CeO2-supported Au-Pt alloy catalyst (Au-Pt/CeO2) using biomass-derived formic acid as the hydrogen source. The success of this reaction is reasonably attributed to the high efficiency of Au-Pt/CeO2 in the tandem steps of formic acid dehydrogenation and carbon-oxygen species hydrodeoxygenation.
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28192758/ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simple-and-simultaneous-quantification-of-cannabinoids
#10
Rohitash Jamwal, Ariel R Topletz, Bharat Ramratnam, Fatemeh Akhlaghi
Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of cannabinoids in human biological specimens rely on complex extraction process and lengthy analysis time. We established a rapid and simple assay for quantification of Δ(9)-tetrahydrocannabinol (THC), cannabidiol (CBD), 11-hydroxy Δ(9)-tetrahydrocannabinol (11-OH THC) and 11-nor-9-carboxy-Δ(9)-tetrahydrocannbinol (THCCOOH) in human plasma by U-HPLC-MS/MS usingΔ9-tetrahydrocannabinol-D3 (THC-D3) as the internal standard...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28191359/simultaneous-determination-of-5-flavonoids-and-7-saponins-for-quality-control-of-traditional-chinese-medicine-preparation-xinnaoshutong-capsule-using-hplc-vwd-elsd
#11
Jin Li, Yang Bai, Peng Zhang, Jun He, Jun Cao, Mingrui An, Li-Min Hu, Xiu-Mei Gao, Yan-Xu Chang
Xinnaoshutong capsule (XC) is a traditional Chinese prescription derived from the ripe fruit of Tribulus terrestris L. (TT). Although XC has long been considered as an important herbal medicine, no analytical method of marker compounds for quality assessment is registered in the Chinese Pharmacopoeia. A simple analytical method of twelve marker components was developed and validated by HPLC-VWD-ELSD method. Chromatographic separation by HPLC was carried out on a Hedera ODS 2 column (4.6 × 250 mm, 5 μm) by gradient elution with acetonitrile-water (0...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28187377/simultaneous-quantification-of-reparixin-and-paclitaxel-in-plasma-and-urine-using-ultra-performance-liquid-chromatography-tandem-mass-spectroscopy-uhplc-ms-ms-application-to-a-preclinical-pharmacokinetic-study-in-rats
#12
Sarandeep Malhi, Nicholas Stesco, Samaa Alrushaid, Ted M Lakowski, Neal M Davies, Xiaochen Gu
A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) assay was developed and validated to simultaneously quantify anticancer drugs reparixin and paclitaxel in this study. The compounds were extracted from plasma and urine samples by protein precipitation with acetone (supplemented with 0.1% formic acid). Chromatographic separation was achieved using a C18 column, and drug molecules were ionized using dual ion source electrospray and atmospheric pressure chemical ionization (DUIS: ESI-APCI). Reparixin and paclitaxel were quantified using negative and positive multiple reaction monitoring (MRM) mode, respectively...
February 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28185178/spatiotemporal-distribution-and-source-apportionment-of-low-molecular-weight-organic-acids-in-wet-precipitation-at-a-coastal-city-china
#13
Wenjiao Du, Zhenyu Hong, Yanting Chen, Junjun Deng, Jinsheng Chen, Lingling Xu, Youwei Hong, Hang Xiao
To investigate the characteristics and sources of low molecular weight (LMW) organic acids in wet precipitation at a coastal city, Xiamen, a total of 313 rainwater samples were collected at seven different functional areas from September 2012 to August 2013. Spatiotemporal characteristics of LMW organic acids as well as pH and electrical conductivity were analyzed. Meanwhile, air mass clusters in different seasons and the positive matrix factorization (PMF) source apportion model were comprehensively used to identify the sources of organic acids...
February 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28178839/substrate-selectivity-in-the-low-temperature-atomic-layer-deposition-of-cobalt-metal-films-from-bis-1-4-di-tert-butyl-1-3-diazadienyl-cobalt-and-formic-acid
#14
Marissa M Kerrigan, Joseph P Klesko, Sara M Rupich, Charles L Dezelah, Ravindra K Kanjolia, Yves J Chabal, Charles H Winter
The initial stages of cobalt metal growth by atomic layer deposition are described using the precursors bis(1,4-di-tert-butyl-1,3-diazadienyl)cobalt and formic acid. Ruthenium, platinum, copper, Si(100), Si-H, SiO2, and carbon-doped oxide substrates were used with a growth temperature of 180 °C. On platinum and copper, plots of thickness versus number of growth cycles were linear between 25 and 250 cycles, with growth rates of 0.98 Å/cycle. By contrast, growth on ruthenium showed a delay of up to 250 cycles before a normal growth rate was obtained...
February 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28176533/simultaneous-assay-of-multiple-antibiotics-in-human-plasma-by-lc-ms-ms-importance-of-optimizing-formic-acid-concentration
#15
Feng Chen, Zhe-Yi Hu, S Casey Laizure, Joanna Q Hudson
AIM: Optimal dosing of antibiotics in critically ill patients is complicated by the development of resistant organisms requiring treatment with multiple antibiotics and alterations in systemic exposure due to diseases and extracorporeal drug removal. Developing guidelines for optimal antibiotic dosing is an important therapeutic goal requiring robust analytical methods to simultaneously measure multiple antibiotics. METHODS: An LC-MS/MS assay using protein precipitation for cleanup followed by a 6-min gradient separation was developed to simultaneously determine five antibiotics in human plasma...
February 8, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28171790/study-on-the-forced-degradation-behaviour-of-ledipasvir-identification-of-major-degradation-products-using-lc-qtof-ms-ms-and-nmr
#16
Debasish Swain, Gananadhamu Samanthula
Ledipasvir, a novel NS5A inhibitor is used in the management of hepatitis C virus infections. The drug was subjected to forced degradation studies as per the conditions prescribed in ICH Q1 (R2) guideline. Ledipasvir degraded in hydrolytic (acid, alkaline and neutral) and oxidative stress conditions. The drug was found to be stable in thermal and photolytic conditions. Eight novel degradation products were obtained and were well separated using an HPLC C18 stationary phase (150×4.6mm, 5μm) and mobile phase composed of formic acid/acetonitrile in gradient elution mode...
January 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28170232/contaminant-removal-from-source-waters-using-cathodic-electrochemical-membrane-filtration-mechanisms-and-implications
#17
Junjian Zheng, Jinxing Ma, Zhiwei Wang, Shaoping Xu, T David Waite, Zhichao Wu
Removal of recalcitrant anthropogenic contaminants from water calls for the development of cost-effective treatment technologies. In this work, a novel electrochemical membrane filtration (EMF) process using a conducting microfiltration membrane as the cathode has been developed and the degradation of sulphanilic acid (SA) examined. The electrochemical degradation of SA in flow-by mode followed pseudo-first-order kinetics with the degradation rate enhanced with increase in charging voltage. Hydrogen peroxide as well as oxidants such as HO• and Fe(IV)O2+ were generated electrochemically with HO• found to be the dominant oxidant responsible for SA degradation...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28169862/quantification-of-acetaminophen-and-its-metabolites-in-plasma-using-uplc-ms-doors-open-to-therapeutic-drug-monitoring-in-special-patient-populations
#18
Robert B Flint, Paola Mian, Bart van der Nagel, Nuria Slijkhuis, Birgit C P Koch
BACKGROUND: Acetaminophen (APAP, paracetamol) is the most commonly used drug for pain and fever in both the United States and Europe and considered safe when used at registered dosages. Nevertheless, differences between specific populations lead to remarkable changes in exposure to potentially toxic metabolites. Furthermore, extended knowledge is required on metabolite formation following intoxication, to optimize antidote treatment. Therefore, the authors aimed to develop and validate a quick and easy analytical method for simultaneous quantification of APAP, APAP-glucuronide, APAP-sulfate, APAP-cysteine, APAP-glutathione, APAP-mercapturate, and protein-derived APAP-cysteine in human plasma by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-MS/MS)...
February 6, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28168648/homogeneous-reduction-of-carbon-dioxide-with-hydrogen
#19
REVIEW
Kaiwu Dong, Rauf Razzaq, Yuya Hu, Kuiling Ding
Carbon dioxide (CO2), a key greenhouse gas produced from both anthropogenic and natural sources, has been recently considered to be an important C1 building-block for the synthesis of many industrial fuels and chemicals. Catalytic hydrogenation of CO2 using a homogeneous system is regarded as an efficient process for CO2 valorization. This approach leads to the direct products including formic acid (HCOOH), carbon monoxide (CO), methanol (MeOH), and methane (CH4). The hydrogenation of CO2 to CO followed by alkene carbonylation provides value-added compounds, which also avoids the tedious separation and transportation of toxic CO...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28167419/comparative-pharmacokinetic-profiles-of-selected-irreversible-tyrosine-kinase-inhibitors-neratinib-and-pelitinib-with-apigenin-in-rat-plasma-by-uplc-ms-ms
#20
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Ashwag O Abahussain
Neratinib (NER) and pelitinib (PEL) are irreversible tyrosine kinase inhibitors (TKIs) that have been recently employed in cancer treatment. Apigenin (API), among other flavonoids, is known to have antioxidant, anti-proliferative, and carcinogenic effect. API can potentiate the antitumor effect of chemotherapeutic agents and/or alleviate the side effects of many anticancer agents. Since TKIs are mostly metabolized by CYP3A4 enzymes and that API could alter the enzymatic activity, potential drug interactions could be expected following their co-aministration...
January 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
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