Kelly L Bolton, Denise Chen, Rosario I Corona de la Fuente, Zhuxuan Fu, Rajmohan Murali, Martin Köbel, Yanis Tazi, Julie M Cunningham, Irenaeus C C Chan, Brian J Wiley, Lea A Moukarzel, Stacey J Winham, Sebastian M Armasu, Jenny Lester, Esther Elishaev, Angela Laslavic, Catherine J Kennedy, Anna Piskorz, Magdalena Sekowska, Alison H Brand, Yoke-Eng Chiew, Paul Pharoah, Kevin M Elias, Ronny Drapkin, Michael Churchman, Charlie Gourley, Anna DeFazio, Beth Karlan, James D Brenton, Britta Weigelt, Michael S Anglesio, David Huntsman, Simon A Gayther, Jason Konner, Francesmary Modugno, Kate Lawrenson, Ellen L Goode, Elli Papaemmanuil
PURPOSE: To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation and outcomes. EXPERIMENTAL DESIGN: We profiled 421 primary CCOCs that passed quality control using a targeted deep sequencing panel of 163 putative CCOC driver genes and whole transcriptome sequencing of 211 of these tumors. Molecularly-defined subgroups were identified and tested for association with clinical characteristics and overall survival...
July 11, 2022: Clinical Cancer Research