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fibrosis amiodarone

Bhaskar Nandi, R Ajay Handa, K S Brar, Umar Nazir Kabli
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Anastasia Zagorianou, Meletios Marougkas, Stavros G Drakos, Nikolaos Diakos, Panagiotis Konstantopoulos, Despina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (LV) remodeling in a porcine model of ischemic cardiomyopathy. Eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). Evolution of LV remodeling over 3 months post-myocardial infarction was examined at tissue level (myocyte size, myocardial fibrosis and vascular density assessed by whole-field digital histopathology), organ level (LV structure and function assessed by echocardiography), and systemic level (BNP and MMP-9 levels)...
2016: SpringerPlus
Poornima Mahavadi, Lars Knudsen, Shalini Venkatesan, Ingrid Henneke, Jan Hegermann, Christoph Wrede, Matthias Ochs, Saket Ahuja, Shashi Chillappagari, Clemens Ruppert, Werner Seeger, Martina Korfei, Andreas Guenther
Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its antiarrhythmic properties. It exerts serious side-effects even in patients receiving low doses. AD is well-known to induce apoptosis of type II alveolar epithelial cells (AECII), a mechanism that has been suggested to play an important role in AD-induced lung fibrosis. The precise molecular mechanisms underlying this disease are, however, still unclear. Because of its amphiphilic nature, AD becomes enriched in the lysosomal compartments, affecting the general functions of these organelles...
October 2015: Journal of Pathology. Clinical Research
Yuichi Hori, Shiro Nakahara, Sohtaro Mine, Naofumi Anjo, Akiko Fujii, Yoshihiko Ueda, Isao Taguchi
A 65-year-old man with non-ischemic cardiomyopathy, underwent an autopsy 2 months after the successful ablation of a sustained left ventricular (LV) summit ventricular tachycardia (VT). The patient died due to interstitial pneumonia from amiodarone use. The earliest activation sites of the VT were documented from both inside the anterior interventricular vein (AIV) and epicardial surface. The diameter of the AIV was 3-4 mm, and the radiofrequency (RF) lesion inside the AIV was a slight lesion due to high impedance with a high temperature...
May 13, 2016: Heart and Vessels
Elizabeth R Magden, Meg M Sleeper, Stephanie J Buchl, Rebekah A Jones, Erica J Thiele, Gregory K Wilkerson
Cardiovascular disease is a leading cause of death in captive chimpanzees and is often associated with myocardial fibrosis, which increases the risk of cardiac arrhythmias. In this case report, we present a 36-y-old male chimpanzee (Pan troglodytes) diagnosed with frequent ventricular premature complexes (VPC). We placed a subcutaneous implantable loop recorder for continual ECG monitoring to assess his arrhythmias without the confounding effects of anesthetics. During his initial treatment with the antiarrhythmia medication amiodarone, he developed thrombocytopenia, and the drug was discontinued...
February 2016: Comparative Medicine
Erik Robinson, Sunjay Kaushal, Justice Alaboson, Sudhish Sharma, Amogh Belagodu, Claire Watkins, Brandon Walker, Gregory Webster, Patrick McCarthy, Dean Ho
Suppressing perioperative inflammation and post-operative atrial fibrillation requires effective drug delivery platforms (DDP). Localized anti-inflammatory and anti-arrhythmic agent release may be more effective than intravenous treatment to improve patient outcomes. This study utilized a dexamethasone (DEX) and amiodarone (AMIO)-loaded Parylene-C (PPX) nano-structured film to inhibit inflammation and atrial fibrillation. The PPX film was tested in an established pericardial adhesion rabbit model. Following sternotomy, the anterior pericardium was resected and the epicardium was abraded...
February 21, 2016: Nanoscale
Abeer A I Sharaf El-Din, Omaima M Abd Allah
Amiodarone (AD) is one of the most frequently prescribed antiarrhythmic agents worldwide but its effectiveness is limited due to the development of pulmonary toxicity. Several lines of evidence have suggested that AT1 receptor antagonists can attenuate pulmonary fibrosis in different animal models. This study was performed to evaluate the effect of olmesartan medoxomil (OM) on lung injury induced in rats by AD which was assessed biochemically (hydroxyproline content, MDA level and SOD activity), histologically (Ashcroft criteria and Masson's trichrome stain) and immunohistochemically (TGF-β1 expression in lung tissue)...
January 18, 2016: Basic & Clinical Pharmacology & Toxicology
Hamid-Reza Nasri, Siyavash Joukar, Hamid Kheradmand, Hamid-Reza Poursalehi, Shahriar Dabiri
OBJECTIVE: The purpose of this study was to evaluate the effect of atorvastatin administration on amiodarone-induced pulmonary fibrosis in rats. MATERIALS AND METHODS: Thirty-six male Wistar rats were randomly divided into 4 groups. The control group (CTL) received distilled water (0.3 ml intratracheally on days 0 and 2 and 0.5 ml orally from day 0 for 3 weeks). The atorvastatin group (AT), in addition to intratracheal distilled water, received 1 mg/kg of atorvastatin orally from day 0 for 3 weeks...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Aashish Sharma, Marco Sartori, Jose J Zaragoza, Gianluca Villa, Renhua Lu, Elena Faggiana, Alessandra Brocca, Luca Di Lullo, Sandro Feriozzi, Claudio Ronco
Cardiorenal syndrome type 5 (CRS-5) includes conditions where there is a simultaneous involvement of the heart and kidney from a systemic disorder. This is a bilateral organ cross talk. Fabry's disease (FD) is a devastating progressive inborn error of metabolism with lysosomal glycosphingolipid deposition in variety of cell types, capillary endothelial cells, renal, cardiac and nerve cells. Basic effect is absent or deficient activity of lysosomal exoglycohydrolase a-galactosidase A. Renal involvement consists of proteinuria, isosthenuria, altered tubular function, presenting in second or third decade leading to azotemia and end-stage renal disease in third to fifth decade mainly due to irreversible changes to glomerular, tubular and vascular structures, especially highlighted by podocytes foot process effacement...
November 2015: Heart Failure Reviews
Jonathan Buggey, Matthew Kappus, Anand S Lagoo, Carla W Brady
We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.
January 2015: ACG Case Reports Journal
Bastian Birkelbach, Dennis Lutz, Clemens Ruppert, Ingrid Henneke, Elena Lopez-Rodriguez, Andreas Günther, Matthias Ochs, Poornima Mahavadi, Lars Knudsen
Chronic injury of alveolar epithelial type II cells (AE2 cells) represents a key event in the development of lung fibrosis in animal models and in humans, such as idiopathic pulmonary fibrosis (IPF). Intratracheal delivery of amiodarone to mice results in a profound injury and macroautophagy-dependent apoptosis of AE2 cells. Increased autophagy manifested in AE2 cells by disturbances of the intracellular surfactant. Hence, we hypothesized that ultrastructural alterations of the intracellular surfactant pool are signs of epithelial stress correlating with the severity of fibrotic remodeling...
July 1, 2015: American Journal of Physiology. Lung Cellular and Molecular Physiology
Manoj Thangam, Sriram Nathan, Marija Petrovica, Biswajit Kar, Manish Patel, Pranav Loyalka, L Maximilian Buja, Igor D Gregoric
A 33-year-old African-American woman was bridged to heart transplantation with a left ventricular assist device. She had a 14-month history of heart failure secondary to viral cardiomyopathy. The patient's refractory ventricular tachycardia was treated with intravenous procainamide owing to the patient's history of amiodarone-induced thyroiditis. After orthotopic cardiac transplant, she experienced prolonged respiratory failure. Serial computed tomography evaluation of the lung revealed diffuse bilateral ground-glass opacities and septal thickening...
July 2015: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
In Sook Kang, Kyung Jin Kim, Yookyung Kim, Seong-Hoon Park
BACKGROUND/AIMS: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate the feasibility of chest computed tomography (CT) as a diagnostic tool for APT and to assess the utility of the CT APT score as an index for predicting the severity of APT. METHODS: Patients underwent amiodarone treatment for various reasons, most often atrial fibrillation, for more than 2 years, and those that received a cumulative dose > 100 g were enrolled...
November 2014: Korean Journal of Internal Medicine
Philippe Bonniaud, Marjolaine Georges, Nicolas Favrolt, Philippe Camus
Drug-induced infiltrative lung disease may manifest as variable clinical radiological patterns, including subacute or chronic interstitial pneumonia, pulmonary fibrosis, eosinophilic pneumonia, organising pneumonia, pulmonary edema, or sarcoidosis. A large amount of drugs have been incriminated, including those used in cardiovascular diseases (amiodarone, statins and angiotensin converting enzyme inhibitors), antibiotics (minocycline, nitrofurantoin), most of anticancer drugs (and especially chemotherapy and chest radiation), treatment of rheumatoid arthritis, as well as more recent drugs...
September 2014: La Revue du Praticien
S S Sirsikar, S M Ranpise, A S Patil, K Y Deodhar
Pulmonary opacities have many causes we are presenting a case of pulmonary opacity in a patient of breathlessness; who was on amiodarone for atrial fibrillation (AF).
April 2014: Journal of the Association of Physicians of India
Wim A Wuyts, Alberto Cavazza, Giulio Rossi, Francesco Bonella, Nicola Sverzellati, Paolo Spagnolo
Idiopathic pulmonary fibrosis (IPF), the most common and lethal of the idiopathic interstitial pneumonias, is defined by a radiological and/or pathological pattern of usual interstitial pneumonia (UIP). However, UIP is not synonymous with IPF as other clinical conditions may be associated with UIP, including chronic hypersensitivity pneumonitis, collagen vascular disease, drug toxicity, asbestosis, familial IPF and Hermansky-Pudlak syndrome. Differentiating IPF ("idiopathic UIP") from conditions that mimic IPF ("secondary UIP") has substantial therapeutic and prognostic implications...
September 2014: European Respiratory Review: An Official Journal of the European Respiratory Society
Poornima Mahavadi, Ingrid Henneke, Clemens Ruppert, Lars Knudsen, Shalini Venkatesan, Gerhard Liebisch, Rachel C Chambers, Matthias Ochs, Gerd Schmitz, Carlo Vancheri, Werner Seeger, Martina Korfei, Andreas Guenther
Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects. Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may cause interstitial pneumonia as well as lung fibrosis. Apoptosis of alveolar epithelial type II cells (AECII) has been suggested to play an important role in this disease. In the current study, we aimed to establish a murine model of AD-induced lung fibrosis and analyze surfactant homeostasis, lysosomal, and endoplasmic reticulum (ER) stress in this model...
November 2014: Toxicological Sciences: An Official Journal of the Society of Toxicology
Maha Baligh Zickri, Sahar Gamal Aboul Fadl, Hala Gabr Metwally
BACKGROUND AND OBJECTIVES: The fibrosing form of lung injury (occupational, environmental, infective or drug induced) is associated with significant morbidity and mortality. Amiodarone (AM), often prescribed for control of arrhythmias is considered a potential cause. No effective treatment was confirmed, except lung transplantation. Intravenous (IV) stem cell therapy may produce pulmonary emboli or infarctions. Despite being commonly used in clinical practice, the intraperitoneal (IP...
May 2014: International Journal of Stem Cells
Stefka Valcheva-Kuzmanova, Galya Stavreva, Violeta Dancheva, Ljudmil Terziev, Milena Atanasova, Angelina Stoyanova, Anelia Dimitrova, Veneta Shopova
BACKGROUND: The fruits of Aronia melanocarpa (Michx.) Elliot is extremely rich in biologically active polyphenols. OBJECTIVE: We studied the protective effect of A. melanocarpa fruit juice (AMFJ) in a model of amiodarone (AD)-induced pneumotoxicity in rats. MATERIALS AND METHODS: AD was instilled intratracheally on days 0 and 2 (6.25 mg/kg). AMFJ (5 mL/kg and 10 mL/kg) was given orally from day 1 to days 2, 4, 9, and 10 to rats, which were sacrificed respectively on days 3, 5, 10, and 28 when biochemical, cytological, and immunological assays were performed...
April 2014: Pharmacognosy Magazine
J Mankikian, O Favelle, A Guillon, L Guilleminault, B Cormier, A P Jonville-Béra, D Perrotin, P Diot, S Marchand-Adam
UNLABELLED: Amiodarone-induced pulmonary toxicity (APT) is a serious adverse event that can lead to death. The aims of our study are to determine factors associated with mortality and to describe outcome and sequelae of patients with APT. METHODS: Forty-six patients with APT were divided into two groups according to survival at day 90 for a clinical, functional, biological and radiological comparaison. We then evaluated the evolution of 15 survivors at a median of three months [1-6 months] and/or 12 months [8-36 months]...
April 2014: Respiratory Medicine
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