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https://www.readbyqxmd.com/read/30243978/sleep-apnea-increases-the-risk-of-new-hospitalized-atrial-fibrillation-a-historical-cohort-study
#1
Tetyana Kendzerska, Andrea Gershon, Clare Atzema, Paul Dorian, Iqwal Mangat, Gillian Hawker, Richard Leung
OBJECTIVES: We examined the relationship between newly diagnosed obstructive sleep apnea (OSA) and incident hospitalized atrial fibrillation (AF) over the subsequent ten years in a large arrhythmia-free cohort. METHODS: Adults referred between 1994 and 2010 to a large academic hospital with suspected OSA who were arrhythmia-free at the time of first diagnostic sleep study were included. Clinical data were linked to provincial health administrative data to define outcome...
September 19, 2018: Chest
https://www.readbyqxmd.com/read/30243113/long-term-administration-of-fatty-acid-amide-hydrolase-inhibitor-urb597-to-rats-with-spontaneous-hypertension-disturbs-liver-redox-balance-and-phospholipid-metabolism
#2
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Elżbieta Skrzydlewska
PURPOSE: The effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate (URB597), inhibitor of fatty acid amide hydrolase (FAAH) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (SHRs) was investigated. MATERIALS/METHODS: Experiments were conducted using SHRs and normotensive control Wistar-Kyoto rats treated by intraperitoneal injection with URB597 for 14 days...
September 19, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30241122/oxygen-exposures-at-nasa-s-neutral-buoyancy-lab-a-20-year-experience
#3
Shane C Walker, Alejandro Garbino, Kristi Ray, Renny Hardwick, Daniel T Fitzpatrick, Robert W Sanders
Astronauts training for extravehicular activity (EVA) operations can spend many hours submerged underwater in a pressurized suit, called an extravehicular mobility unit (EMU), exposed to pressures exceeding 2 atmospheres absolute (ATA). To minimize the risk of decompression sickness (DCS) a 46% nitrox mixture is used. This limits the nitrogen partial pressure, decreasing the risk of DCS. The trade-off with using a 46% nitrox mixture is the increased potential for oxygen toxicity, which can lead to severe neurologic symptoms including seizures...
July 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/30241121/effect-of-hyperbaric-oxygen-treatment-in-central-retinal-artery-occlusion
#4
Bekir Selim Bagli, Sadik Görkem Çevik, Mediha Tok Çevik
Background: Central retinal artery occlusion (CRAO) is a rare and serious ophthalmologic emergency with a bad prognosis. Hyperbaric oxygen (HBO2) treatment has been reported to improve visual acuity of CRAO patients. However, there are unknown variables for HBO2 treatment such as initiation period, number of sessions and efficacy. In this study, we aimed to investigate efficacy of HBO2 treatment in CRAO patients. Methods: Patients who had been diagnosed with CRAO and referred to our Hyperbaric Oxygen Treatment Unit with the indication of HBO2 treatment were included in the study...
July 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/30240953/targeted-cellular-delivery-of-robust-enzyme-nanoparticles-for-the-treatment-of-drug-induced-hepatotoxicity-and-liver-injury
#5
Min Sang Lee, Nak Won Kim, Jung Eun Lee, Myung Goo Kim, Yue Yin, Sun Young Kim, Bo Sung Ko, Aeseon Kim, Jong Han Lee, Su Yeon Lim, Dong Woo Lim, Sun Hwa Kim, Ji Won Park, Yong Taik Lim, Ji Hoon Jeong
Direct delivery of proteins into cells has been considered an effective approach for treating the protein-related diseases. However, clinical use of proteins has still been limited due to their instability in the blood and poor membrane permeability. To achieve an efficient cellular delivery of the protein to target cells via a systemic administration, a multifunctional carrier system having desirable stability both in the blood stream and the cells, specific cell-targeting property and endosomal escape functions may be required...
September 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30240793/sglt1-inhibition-pros-and-cons
#6
REVIEW
Vasilis Tsimihodimos, Sebastien Filippas-Ntekouan, Moses Elisaf
Sodium Glucose Cotransporters 1 (SGLT1) play important roles in the intestinal absorption of glucose and the renal reabsorption of glucose, especially in patients with uncontrolled diabetes and those receiving SGLT2 inhibitors. As a consequence, the inhibition of SGLT1 transporters may represent an interesting therapeutic option in patients with diabetes. However, genetic models of SGLT1 inactivation indicate that the malfunction of these transporters may have adverse effects on various tissues. In this review, we discuss the available evidence on the beneficial and detrimental effects that the inhibition of SGLT1 transporters might have...
September 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30237735/anticancer-and-cardio-protective-effects-of-liposomal-doxorubicin-in-the-treatment-of-breast-cancer
#7
REVIEW
Yesenia L Franco, Tanaya R Vaidya, Sihem Ait-Oudhia
Breast cancer (BC) is a highly prevalent disease, accounting for the second highest number of cancer-related mortalities worldwide. The anthracycline doxorubicin (DOX), isolated from Streptomyces peucetius var. caesius , is a potent chemotherapeutic drug that is successfully used to treat various forms of liquid and solid tumors and is currently approved to treat BC. DOX exerts its effects by intercalation into DNA and inhibition of topoisomerases I and II, causing damage to DNA and the formation of reactive oxygen species (ROS), resulting in the activation of caspases, which ultimately leads to apoptosis...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30237578/astaxanthin-alleviated-ethanol-induced-liver-injury-by-inhibition-of-oxidative-stress-and-inflammatory-responses-via-blocking-of-stat3-activity
#8
Ji Hye Han, Jung Heun Ju, Yong Sun Lee, Ju Ho Park, In Jun Yeo, Mi Hee Park, Yoon Seok Roh, Sang Bae Han, Jin Tae Hong
Astaxanthin (AXT) is classified as a xanthophyll carotenoid compound which have broader functions including potent antioxidant, anti-inflammatory and neuroprotective properties. Considerable researches have demonstrated that AXT shows preventive and therapeutic properties against for Diabetes, Osteoarthritis and Rheumatoid Arthritis. However, the protective effect of AXT on liver disease has not yet been reported. In this study, we investigated effects of AXT on ethanol-induced liver injury in chronic plus binge alcohol feeding model...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30235661/assessment-of-graft-perfusion-and-oxygenation-for-improved-outcome-in-esophageal-cancer-surgery-protocol-for-a-single-center-prospective-observational-study
#9
Elke Van Daele, Yves Van Nieuwenhove, Wim Ceelen, Christiaan Vanhove, Bart P Braeckman, Anne Hoorens, Jurgen Van Limmen, Oswald Varin, Dirk Van de Putte, Wouter Willaert, Piet Pattyn
INTRODUCTION: The main cause of anastomotic leakage (AL) is tissue hypoxia, which results from impaired perfusion of the pedicle stomach graft after esophageal reconstruction. Clinical judgment is unreliable in determining graft perfusion. Therefore, an objective, validated, and reproducible method is urgently needed. Near infrared fluorescence perfusion imaging using indocyanine green (ICG) is an emerging and promising modality. This study's objectives are to evaluate the feasibility of quantification of ICG angiography (ICGA) to assess graft perfusion and to validate ICGA by comparison with hemodynamic parameters, blood and tissue expression of hypoxia-induced markers, and tissue mitochondrial respiration rates...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30235451/apelin-13-administration-protects-against-lps-induced-acute-lung-injury-by-inhibiting-nf-%C3%AE%C2%BAb-pathway-and-nlrp3-inflammasome-activation
#10
Hailin Zhang, Sha Chen, Meichun Zeng, Daopeng Lin, Yu Wang, Xunhang Wen, Changfu Xu, Li Yang, Xiaofang Fan, Yongsheng Gong, Hongyu Zhang, Xiaoxia Kong
BACKGROUND/AIMS: Acute lung injury (ALI) is induced by a variety of external and internal factors and leads to acute progressive respiratory failure. Previous studies have shown that apelin-13 can decrease the acute lung injury induced by LPS, but the specific mechanism is unclear. Therefore, a mouse lung injury model and a cell model were designed to explore the mechanism of how apelin-13 alleviates the acute lung injury caused by LPS. METHODS: The effect of apelin-13 on LPS-induced structural damage was determined by H&E staining and by the wet/dry weight ratio...
September 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30235299/oxygen-therapy-may-worsen-the-survival-rate-in-rats-with-monocrotaline-induced-pulmonary-arterial-hypertension
#11
Naoto Fujita, Natsuki Yamasaki, Kanako Eto, Makoto Asaeda, Wataru Kuwahara, Hidetaka Imagita
Although oxygen therapy rapidly improves arterial oxygen saturation in idiopathic pulmonary arterial hypertension, the effects of chronic administration of oxygen are unknown. The purpose of the present study was to investigate the effects of chronic oxygen therapy on the histological changes and survival rate in rats with idiopathic pulmonary arterial hypertension. Idiopathic pulmonary arterial hypertension was induced by monocrotaline injection. The rats were then randomly assigned to receive or not receive oxygen therapy (O2 group and non-O2 group, respectively)...
2018: PloS One
https://www.readbyqxmd.com/read/30234112/antioxidative-cxxc-peptide-motif-from-mesencephalic-astrocyte-derived-neurotrophic-factor-antagonizes-programmed-cell-death
#12
Valentina Božok, Li-Ying Yu, Jaan Palgi, Urmas Arumäe
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a potent survival-promoting protein with neurorestorative effect for neurodegenerative diseases. Its mechanism of action, albeit poorly known, depends strongly on the CXXC motif (CKGC). Here we studied the survival-promoting properties of the CKGC tetrapeptide from MANF. In the Jurkat T lymphocytic cell line, CKGC potently inhibits death receptor Fas-induced apoptosis and mildly counteracts mitochondrial apoptosis and necroptosis. The peptide with serines instead of cysteines (SKGS) has no survival-promoting activity...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/30232174/decreased-expression-of-pigment-epithelium-derived-factor-within-the-penile-tissues-contributes-to-erectile-dysfunction-in-diabetic-rats
#13
Hongjie Qiao, Yuanyuan Zhang, Wenwen Lin, Yu-Feng Wang, Cristina M Furdui, Qiuling Jiang, Xiao Li, Ting Long, Yunguang Wang, Da-Nian Qin
Increased production of reactive oxygen species (ROS) and inflammation are major contributors to the development and progression of diabetes-associated erectile dysfunction (DMED). As an endogenous anti-oxidant and anti-inflammatory factor, the potential implication of pigment epithelium-derived factor (PEDF) in DMED has not been revealed. To assess the potential antioxidant and anti-inflammatory function of PEDF in DMED, we first demonstrated that PEDF was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls...
September 19, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/30226445/response-to-lenvatinib-in-children-with-papillary-thyroid-carcinoma
#14
Priya Mahajan, Jonathan Dawrant, Albert Kheradpour, Norma M Quintanilla, Monica E Lopez, Robert C Orth, Ioanna Athanassaki, Rajkumar Venkatramani
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy in children and adolescents. Infrequently, children with PTC may present with or develop disease not amenable to surgery or radioactive iodine (RAI), and systemic therapy may be an option. Lenvatinib is an oral tyrosine kinase inhibitor that is approved by the Food and Drug Administration for the treatment of adults with locally recurrent or metastatic, progressive, RAI-refractory well differentiated thyroid carcinoma...
September 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30226240/targeting-myeloid-regulators-by-paclitaxel-loaded-enzymatically-degradable-nanocups
#15
Seth C Burkert, Galina V Shurin, David L White, Xiaoyun He, Alexandr A Kapralov, Valerian E Kagan, Michael R Shurin, Alexander Star
Tumor microenvironment is characterized by immunosuppressive mechanisms associated with the accumulation of immune regulatory cells - myeloid-derived suppressor cells (MDSC). Therapeutic depletion of MDSC has been associated with inhibition of tumor growth and therefore represents an attractive approach to cancer immunotherapy. MDSC in cancer are characterized by enhanced enzymatic capacity to generate reactive oxygen and nitrogen species (RONS) which have been shown to effectively degrade carbonaceous materials...
September 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/30224944/ss-31-provides-neuroprotection-by-reversing-mitochondrial-dysfunction-after-traumatic-brain-injury
#16
Yihao Zhu, Handong Wang, Jiang Fang, Wei Dai, Jiang Zhou, Xiaoliang Wang, Mengliang Zhou
SS-31, a novel mitochondria-targeted peptide, has been proven to provide neuroprotection in a variety of neurological diseases. Its role as a mitochondrial reactive oxygen species (ROS) scavenger and the underlying pathophysiological mechanisms in traumatic brain injury (TBI) are still not well understood. The aim of the designed study was to investigate the potential neuroprotective effects of SS-31 and fulfill our understanding of the process of the mitochondrial change in the modified Marmarou weight-drop model of TBI...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30221765/survey-analysis-of-the-use-effectiveness-and-patient-reported-tolerability-of-inhaled-oxygen-compared-with-injectable-sumatriptan-for-the-acute-treatment-of-cluster-headache
#17
Emmanuelle A D Schindler, Douglas A Wright, Marsha J Weil, Christopher H Gottschalk, Brian P Pittman, Jason J Sico
OBJECTIVE: In this secondary analysis of the Clusterbusters® Medication Use survey, the use, effectiveness, and tolerability of inhaled oxygen were investigated and compared with injectable sumatriptan. We also sought to understand the predictors of medication response. BACKGROUND: Inhaled oxygen is a mainstay abortive intervention in cluster headache but is not approved by the Food and Drug Administration (FDA). Unlike injectable sumatriptan, the only FDA-approved pharmacologic intervention for cluster headache, oxygen can be used multiple times a day, which is highly relevant for a condition with numerous daily attacks...
September 17, 2018: Headache
https://www.readbyqxmd.com/read/30221185/photodynamic-therapy-mediated-immune-therapy-of-brain-tumors
#18
Henry Hirschberg, Kristian Berg, Qian Peng
Photodynamic therapy of tumors requires the topical, systemic or oral administration of a photosensitizing compound, illumination of the tumor area by light of a specific wavelength and the presence of oxygen. Light activation of the photosensitizer transfers energy to molecular oxygen creating singlet oxygen, a highly reactive and toxic species that rapidly reacts with cellular components causing oxidative damage, ultimately leading to cell death. Tumor destruction caused by photodynamic therapy is not only a result of direct tumor cell toxicity via the generation of reactive oxygen species but there is also an immunological and vascular component involved...
2018: Neuroimmunology and Neuroinflammation
https://www.readbyqxmd.com/read/30219120/thermal-regulation-of-emergency-oxygen-supplies-in-commercial-space-vehicles
#19
James M Pattarini, Rebecca S Blue, David J Alexander
INTRODUCTION: While NASA requires that commercial spaceflight vehicles provide onboard emergency oxygen supplies for crew, there are currently no requirements in place regarding thermal constraints of delivered gas. The question has been raised whether or not onboard emergency oxygen supplies must be warmed prior to administration to the crew, as inclusion of warming capabilities will increase the complexity and mass of life support systems in the vehicle. We sought to identify the risk of various inhaled oxygen temperatures and resultant pulmonary inflammatory response in potentially injured crewmembers...
October 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/30218980/myeloperoxidase-deficiency-attenuates-systemic-and-dietary-iron-induced-adverse-effects
#20
Xia Xiao, Piu Saha, Beng San Yeoh, Jennifer A Hipp, Vishal Singh, Matam Vijay-Kumar
Iron deficiency is routinely treated with oral or systemic iron supplements, which are highly reactive and could induce oxidative stress via augmenting the activity of proinflammatory enzyme myeloperoxidase (MPO). To investigate the extent to which MPO is involved in iron-induced toxicity, acute (24 h) iron toxicity was induced by intraperitoneal administration of FeSO4 (25 mg/kg body weight) to MPO-deficient (MpoKO) mice and their wild-type (WT) littermates. Acute iron toxicity was also assessed in WT mice pretreated with an MPO inhibitor, 4-aminobenzoic acid hydrazide...
August 21, 2018: Journal of Nutritional Biochemistry
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