keyword
https://read.qxmd.com/read/38535998/targeting-mitochondrial-dysfunction-using-methylene-blue-or-mitoquinone-to-improve-skeletal-aging
#1
JOURNAL ARTICLE
Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, Shoshana Yakar
Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in vitro and in vivo settings. Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive oxygen species. To investigate the effect of long-term administration of MB on skeletal morphology, we administered MB to aged (18 months old) female C57BL/J6 mice, as well as to adult male and female mice with a genetically diverse background (UM-HET3)...
March 25, 2024: Aging
https://read.qxmd.com/read/38534474/engineered-dual-antioxidant-enzyme-complexes-targeting-icam-1-on-brain-endothelium-reduce-brain-injury-associated-neuroinflammation
#2
JOURNAL ARTICLE
Brian M Leonard, Vladimir V Shuvaev, Trent A Bullock, Kalpani N Udeni Galpayage Dona, Vladimir R Muzykantov, Allison M Andrews, Servio H Ramirez
The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species, which are key mediators of TBI pathology. The role of the blood-brain barrier (BBB) is essential for proper neuronal function and is vulnerable to oxidative stress. Results herein explore the notion that attenuating oxidative stress at the vasculature after TBI may result in improved BBB integrity and neuroprotection...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534392/eye-drop-with-fas-blocking-peptide-attenuates-age-related-macular-degeneration
#3
JOURNAL ARTICLE
Yujong Yi, Seon-Hong Pyun, Chae-Yeon Kim, Gyeongju Yun, Eunhwa Kang, Seoyoun Heo, Irfan Ullah, Sang-Kyung Lee
Age-related macular degeneration (AMD), characterized by macular retinal degeneration, poses a significant health concern due to the lack of effective treatments for prevalent dry AMD. The progression of AMD is closely linked to reactive oxygen species and Fas signaling, emphasizing the need for targeted interventions. In this study, we utilized a NaIO3 -induced retinal degeneration mouse model to assess the efficacy of Fas-blocking peptide (FBP). Intravitreal administration of FBP successfully suppressed Fas-mediated inflammation and apoptosis, effectively arresting AMD progression in mice...
March 20, 2024: Cells
https://read.qxmd.com/read/38530761/probiotics-supplementation-in-the-treatment-of-male-infertility-a-systematic-review
#4
REVIEW
Licia Cristina Silva de Lima Oliveira, Elton Carvalho Costa, Fernanda Domingues Gomes Martins, Alcenir Sales da Rocha, Girlandia Alexandre Brasil
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents...
March 26, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38530061/covid-19-severity-and-mortality-in-veterans-with-chronic-lung-disease
#5
JOURNAL ARTICLE
Kristina Crothers, Scott V Adams, Aaron P Turner, Lisa Batten, Reyhaneh Nikzad, John R Kundzins, Vincent S Fan
INTRODUCTION: Chronic lung disease (CLD) has been associated with risk for more severe manifestations and death with COVID-19. However, few studies have evaluated the risk overall and by type of CLD for severity of COVID-19 outcomes in a US national cohort. METHODS: Using data from the Veterans Health Administration, we determined the risk associated with CLDs including COPD (mild/severe), asthma (mild/active/severe), idiopathic pulmonary fibrosis (IPF), sarcoidosis and other interstitial lung diseases (ILDs) for outcomes among veterans with SARS-CoV-2 positive tests between 3/1/2020-4/30/2021...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38528388/nanoparticle-drug-delivery-systems-responsive-to-tumor-microenvironment-promising-alternatives-in-the-treatment-of-triple-negative-breast-cancer
#6
REVIEW
Ye Cao, Fansu Meng, Tiange Cai, Lanwen Gao, Jaiwoo Lee, Sergey O Solomevich, Uladzislau E Aharodnikau, Tingting Guo, Meng Lan, Fengjie Liu, Qianwen Li, Timoshenko Viktor, Detang Li, Yu Cai
The conventional therapeutic treatment of triple-negative breast cancer (TNBC) is negatively influenced by the development of tumor cell drug resistant, and systemic toxicity of therapeutic agents due to off-target activity. In accordance with research findings, nanoparticles (NPs) responsive to the tumor microenvironment (TME) have been discovered for providing opportunities to selectively target tumor cells via active targeting or Enhanced Permeability and Retention (EPR) effect. The combination of the TME control and therapeutic NPs offers promising solutions for improving the prognosis of the TNBC because the TME actively participates in tumor growth, metastasis, and drug resistance...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38525077/the-effect-and-mechanism-of-volatile-oil-emulsion-from-leaves-of-clausena-lansium-lour-skeels-on-staphylococcus-aureus-in-vitro
#7
JOURNAL ARTICLE
Yan-Na Guo, Ke-Ren He, Shao-Shan Liang, Rui-Wei Mou, Meng-Han Lu, Yong-Ming He, Lu-Ping Tang
This study aimed to develop a suitable dosage form of volatile oil from wampee leaves and to explore its antibacterial mechanism in vitro . The chemical composition of the volatile oil from wampee leaves was determined by gas chromatography-mass spectrometry (GC-MS). Different microemulsion ratios were tested and their stabilities were investigated to determine the optimal ratio. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the wampee leaves volatile oil emulsion (WVOE) against Salmonella typhimurium ( S...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38524568/the-zeep-peep-test-to-evaluate-the-response-to-positive-end-expiratory-pressure-delivered-by-helmet-a-prospective-physiologic-study
#8
JOURNAL ARTICLE
Marco Giani, Benedetta Fumagalli, Francesco Cipulli, Emanuele Rezoagli, Matteo Pozzi, Denise Fumagalli, Letizia Fumagalli, Katia Ferrari, Roberto Rona, Giacomo Bellani, Alberto Lucchini, Giuseppe Foti
INTRODUCTION: The improvement in oxygenation after helmet application in hypoxemic patients may be explained by the alveolar recruitment obtained with positive end expiratory pressure (PEEP) or by the administration of a more accurate inspiratory fraction of oxygen (Fi O2 ). We have designed the "ZEEP-PEEP test", capable to distinguish between the Fi O2 -related or PEEP-related oxygenation improvement. Our primary aim was to describe the use of this test during helmet CPAP to assess the oxygenation improvement attributable to PEEP application...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524548/sequential-respiratory-support-in-septic-patients-undergoing-continuous-renal-replacement-therapy-a-study-based-on-mimic-iii-database
#9
JOURNAL ARTICLE
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
OBJECTIVE: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT). METHODS: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524101/changes-in-feno-d-roms-and-bh-4-by-intravenous-l-arginine-in-children-and-its-putative-role-in-asthma-treatment
#10
JOURNAL ARTICLE
Naho Yamamoto, Saki Kasuga, Daijiro Kabata, Myu Ono, Sakura Ando, Taisuke Hashimoto, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki
PURPOSE: Pteridines are metabolites of tetrahydrobiopterin (BH4 ), being coenzymes for nitric oxide synthase (NOS). No study has clarified the relationship among pteridines and NOS, fractional exhaled nitric oxide (FeNO) generated by pteridines, and reactive oxygen species. In this study, we administered arginine, a precursor of NO, and confirmed changes in the levels of pteridines, FeNO, and reactive oxygen species and their relationship to clarify the pathogenesis of airway inflammation in which oxidative stress is involved, such as bronchial asthma...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38524063/fulminant-myocarditis-and-venoarterial-extracorporeal-membrane-oxygenation-a-systematic-review
#11
REVIEW
Spencer E Briglio, Viraj Khanduja, Justin D Lothan, Vasavi Rakesh Gorantla
This systematic review aimed to look at the effectiveness of venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy in treating fulminant myocarditis and evaluating the optimal length of time a patient should be placed on VA-ECMO. Fulminant myocarditis is a potentially life-threatening medical condition most commonly brought on by cardiogenic shock, which often progresses to severe circulatory compromise, requiring the patient to be placed on some form of mechanical circulatory assistance to maintain adequate tissue perfusion...
February 2024: Curēus
https://read.qxmd.com/read/38523877/effect-of-dexmedetomidine-on-oxygen-and-intrapulmonary-shunt-qs-qt-during-one-lung-ventilation-in-pediatric-surgery-a-randomized-controlled-trial
#12
JOURNAL ARTICLE
Ayham Khddam, Faten Rostom, Mohammad Y Hajeer
Background One-lung ventilation (OLV) is a common ventilation technique used during thoracic surgery. It can cause serious complications in children, and hypoxic pulmonary vasoconstriction (HPV) is a protective mechanism against the resulting hypoxia. Dexmedetomidine does not affect HPV, so we will investigate its impact on the partial pressure of oxygen in arterial blood (PaO2) and pulmonary shunt fraction (Qs/Qt). Methods Children who underwent OLV were divided into two equal groups. The Dex group received 0...
March 2024: Curēus
https://read.qxmd.com/read/38523733/resistance-training-in-cardiovascular-diseases-a-review-on-its-effectiveness-in-controlling-risk-factors
#13
REVIEW
Arnengsih Nazir, Henhen Heryaman, Cep Juli, Azizah Ugusman, Januar Wibawa Martha, Marina Annette Moeliono, Nur Atik
Cardiovascular Disease (CVD), a term encompassing various disorders affecting the heart and blood vessels, includes coronary artery disease (CAD). CAD is primarily due to the development of atherosclerotic plaques that disrupt blood flow, oxygenation, and nutrient delivery to the myocardium. Risk factors contributing to CAD progression include smoking, hypertension, diabetes mellitus (DM), dyslipidaemia, and obesity. While aerobic exercise (AE) has shown promising results in controlling CVD risk factors, the impact of resistance training (RT) has not been extensively investigated...
2024: Integrated Blood Pressure Control
https://read.qxmd.com/read/38523198/ozone-infiltration-as-an-adjunctive-treatment-to-piezoelectric-surgery-in-the-management-of-medication-related-osteonecrosis-of-the-jaws-case-series-of-29-patients
#14
JOURNAL ARTICLE
Funda Goker, Girolamo Donati, Francesco Gallo, Antonella Sparaco, Vito Rania, Alberto Busa, Francesco Grecchi, Emma Grecchi, Gianluca Colapinto, Massimo Del Fabbro
PURPOSE: Medication-related osteonecrosis of the jaws has been reported to be associated with bisphosphonate and RANKL inhibitor medications. This prospective clinical study aimed to assess the outcomes of pre-operative ozone infiltration therapy in patients with established MRONJ. METHODS: The treatment protocol for ozone applications were designed as 20 applications ozone infiltration therapy followed by surgical interventions of necrotic tissue debridement using piezoelectric surgery instruments...
March 25, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38522941/synthesis-of-ottonia-anisum-extract-mediated-zno-nps-and-their-local-anesthetic-analgesic-and-hcl%C3%A2-induced-acute-lung-injury-activities
#15
JOURNAL ARTICLE
Guiqin Fan, Jing Yu, Zhengzheng Tao, Xingjia Qian, Qinghong Qian, Jun Shu, Dongfang Shi, Luhong Shen, Bing Lu, Hong Lv
In this study, we outlined the green synthesis of Zinc oxide nanoparticles (ZnO NPs) using the plant-mediated method. Employing the nitrate derivative of Zinc and the extract from the native medicinal plant, Ottonia anisum, the nanoparticles were effectively produced. After obtaining a yellow-colored paste, it was meticulously dried, gathered, and set aside for subsequent examination. The UV-visible spectrometry analysis indicated an absorption peak at 320 nm, which is indicative of ZnO NPs. Characterization techniques, such as XRD and HR-TEM, confirmed the existence of agglomerated ZnO NPs with an average diameter of 40 nm...
March 25, 2024: Journal of Oleo Science
https://read.qxmd.com/read/38521474/suppression-of-nsclc-progression-via-the-co-administration-of-danusertib-an-aurk-inhibitor-and-kribb11-an-hsf1-inhibitor
#16
JOURNAL ARTICLE
Xiang Zhang, Ying Lei, Xiang Chen, Jiahuang He, Zitian Liu, Wentao Zhu, Yi Xu, Xuru Jin
Aurora kinase (AURK) and heat shock factor 1 (HSF1) are commonly overexpressed in non-small cell lung cancer (NSCLC), correlating with poor prognosis. This study aims to assess the therapeutic potential of combining the Danusertib (Danu, AURK inhibitor) and KRIBB11 (HSF1 inhibitor) for NSCLC treatment. The effects of this combination were investigated in A549 cells and a tumor xenograft mouse model. The findings demonstrate that concurrent administration of Danu and KRIBB11 effectively impedes cell proliferation, induces apoptosis, and triggers G2/M cell cycle arrest...
March 21, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38521371/cardioprotective-potential-of-compound-3k-a-selective-pkm2-inhibitor-in-isoproterenol-induced-acute-myocardial-infarction-a-mechanistic-study
#17
JOURNAL ARTICLE
Mohd Rihan, Shyam Sunder Sharma
Myocardial infarction (MI) or heart attack arises from acute or chronic prolonged ischemic conditions in the myocardium. Although several risk factors are associated with MI pathophysiology, one of the risk factors is an imbalance in the oxygen supply. The current available MI therapies are still inadequate due to the complexity of MI pathophysiology. Pyruvate kinase M2 (PKM2) has been implicated in numerous CVDs pathologies. However, the effect of specific pharmacological intervention targeting PKM2 has not been studied in MI...
March 21, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38521369/l-methionine-accentuates-anti-tumor-action-of-gefitinib-in-gefitinib-resistant-lung-adenocarcinoma-role-of-egfr-erk-akt-signaling-and-histone-h3k36me2-alteration
#18
JOURNAL ARTICLE
Swagata Pal, Shaheen Wasil Kabeer, Kulbhushan Tikoo
Adenocarcinoma, the predominant subtype of non-small cell lung cancer (NSCLC), poses a significant clinical challenge due to its prevalence and aggressive nature. Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor is often susceptible to development of resistance despite being the preferred treatment option for NSCLC. In this study, we investigated the potential of L-Methionine in enhancing the cytotoxicity of Gefitinib and preventing resistance development. In vitro experiment employing the H1975 cell line demonstrated a notable enhancement in cytotoxic efficacy when L-Methionine (10 mM) was combined with Gefitinib, as indicated by a substantial reduction in IC50 values (155...
March 21, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38520788/syringin-alleviates-bisphenol-a-induced-spermatogenic-defects-and-testicular-injury-by-suppressing-oxidative-stress-and-inflammation-in-male-zebrafish
#19
JOURNAL ARTICLE
Ye Zhao, Xu Luo, Jinyuan Hu, Mogellah John Panga, Clara Appiah, Zhanxiang Du, Lin Zhu, Vladimir Retyunskiy, Xing Gao, Bo Ma, Qi Zhang
Syringin (SRG) is a bioactive principle possessing extensive activities including scavenging of free radicals, inhibition of apoptosis, and anti-inflammatory properties. However, its effects on spermatogenic defects and testicular injury as well as the underlying mechanisms are still unclear. This study aims to investigate the protective effect of SRG on testis damage in zebrafish and explore its potential molecular events. Zebrafish testicular injury was induced by exposure to bisphenol A (BPA) (3000 μg/L) for two weeks...
March 22, 2024: International Immunopharmacology
https://read.qxmd.com/read/38518637/exploring-the-role-and-mechanism-of-hyperoside-against-cardiomyocyte-injury-in-mice-with-myocardial-infarction-based-on-jak2-stat3-signaling-pathway
#20
JOURNAL ARTICLE
Tingcai Rao, Hua Tong, Jing Li, Jiahao Huang, Yanyan Yin, Junyan Zhang
BACKGROUND: Myocardial infarction (MI) is one of the most deadly diseases in the world. Hyperoside (Hyp) has been shown to have a protective effect on cardiovascular function through various signaling pathways, but whether it can protect myocardial infarction by regulating JAK2/STAT3 signaling pathway is unknown. AIM OF THE STUDY: To investigate whether Hyp could protect the heart against myocardial infarction injury in mice by modulating JAK2/STAT3 signaling pathway and its potential mechanism...
December 25, 2023: Phytomedicine
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