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oxygen administration

David Bennett, Antonella Fossi, Luca Marchetti, Nicola Lanzarone, Sauro Sisi, Rosa Metella Refini, Piersante Sestini, Luca Luzzi, Piero Paladini, Paola Rottoli
OBJECTIVES: Acute kidney injury (AKI) is a common postoperative complication after lung transplantation. The aim of the present study was to evaluate the incidence of AKI in lung transplant patients and its effect on patients and graft outcome in relation to degree of severity. METHODS: Data from 135 patients who underwent lung transplant in the same Italian institution were recorded retrospectively and analysed (69 unilateral and 66 bilateral lung transplants, age 51...
January 10, 2019: Interactive Cardiovascular and Thoracic Surgery
Gábor Bari, Dániel Érces, Gabriella Varga, Szilárd Szucs, Zoltán Varga, Gábor Bogáts, Mihály Boros
OBJECTIVES: Extracorporeal circulation induces cellular and humoral inflammatory reactions, thus possibly leading to detrimental secondary inflammatory responses. Previous data have demonstrated the bioactive potential of methane and confirmed its anti-inflammatory effects in model experiments. Our goal was to investigate the in vivo consequences of exogenous methane administration on extracorporeal circulation-induced inflammation. METHODS: Two groups of anaesthetized Vietnamese minipigs (non-treated and methane treated, n = 5 each) were included...
January 12, 2019: European Journal of Cardio-thoracic Surgery
Hongying Zhao, Hongguang Chen, Meng Xiaoyin, Guotao Yang, Ying Hu, Keliang Xie, Yonghao Yu
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) undergoes the process of pathological event including lung tissue dysfunction, pulmonary edema, and inflammation in sepsis. Autophagy is a cytoprotective process recognized as one of the major pathways for degradation and recycling of cellular constituents. Autophagy as a protective or maladaptive response was still confused in ALI during sepsis. Acute lung injury was performed by cecal ligation and puncture (CLP). Autophagic inducer rapacymin and inhibitor 3-MA and autophagosomal-lysosome fusion inhibitor bafilomucin (Baf) A1 and chloroquine (CQ) were administrated by intraperitoneal injection at 1 h after CLP operation...
January 15, 2019: Inflammation
Min Yi, Hekai Li, Xiaoya Wang, Jianyun Yan, Long Gao, Yinyan He, Xinglong Zhong, Yanbin Cai, Weijing Feng, Zhanpeng Wen, Chengtie Wu, Caiwen Ou, Jiang Chang, Minsheng Chen
Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border-zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell-cell communications...
January 9, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Asa Ahimbisibwe, Kevin Coughlin, Genevieve Eastabrook
OBJECTIVE: This study sought to determine the incidence and severity of respiratory morbidity among late preterm and term babies born by elective Caesarean section (CS) in London, Ontario. METHODS: A retrospective chart review was conducted of all elective CSs performed at or beyond 36+0 weeks gestation from June 2010 to June 2014 at London Health Sciences Centre and St. Joseph's Health Care (Canadian Task Force Classification II-2). RESULTS: The main indications for elective CS were previous CS (59...
January 12, 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
David Bellamy, Gabrielle Nuthall, Stuart Dalziel, Jonathan R Skinner
OBJECTIVES: To raise awareness among pediatric intensive care specialists of catecholaminergic polymorphic ventricular tachycardia; an uncommon cause of polymorphic ventricular tachycardia and ventricular fibrillation arrest in children and young adults where epinephrine (adrenaline), even when given according to international protocols, can be counter-productive and life-threatening. We review three cases of cardiac arrest in children, later proven to be catecholaminergic polymorphic ventricular tachycardia related, where delay in recognition of this condition resulted in significantly longer resuscitation efforts, more interventions, and a longer time to return of spontaneous circulation...
January 11, 2019: Pediatric Critical Care Medicine
Marina Makrecka-Kuka, Stanislava Korzh, Karlis Vilks, Reinis Vilskersts, Helena Cirule, Maija Dambrova, Edgars Liepinsh
Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this study was to evaluate the changes in heart, brain and kidney mitochondrial function in an experimental model of lipopolysaccharide (LPS)-induced endotoxaemia.Samples were collected 4 and 24 h after single injection of LPS (10 mg/kg) in mice. Marked increases in inflammation-related gene expression were observed in all studied tissues 4 h after LPS administration...
January 9, 2019: Shock
Eirini Koutsouraki, Steve Pells, Paul A De Sousa
Hypoxia benefits undifferentiated pluripotent stem cell renewal, and 2-oxoglutarate (2OG) dioxygenases have been implicated in pluripotent stem cell induction and renewal. We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2 ) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hydroxymethylcytosine (5hmC)...
December 12, 2018: Stem Cell Research
Ying Cheng, Dao-Zhou Liu, Chang-Xiong Zhang, Han Cui, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Zi-Fan Lu, Si-Yuan Zhou
Efficient delivery of antioxidant drugs into mitochondria of ischemic cardiomyocytes where reactive oxygen species largely induced is a major challenge for precise treatment of myocardial ischemia-reperfusion injury. Herein, we report a smart dual-shell polymeric nanoparticle, MCTD-NPs, which utilizes multistage continuous targeted strategy to deliver reactive oxygen species scavenger specifically to mitochondria of ischemic cardiomyocytes upon systemic administration. In vitro experiments indicated that the intracellular uptake of MCTD-NPs was specifically enhanced in hypoxia reoxygenation injured H9c2 cells...
January 9, 2019: Nanomedicine: Nanotechnology, Biology, and Medicine
Sevil Korkmaz-Icöz, Shiliang Li, Regina Hüttner, Mihály Ruppert, Tamás Radovits, Sivakkanan Loganathan, Alex Ali Sayour, Paige Brlecic, Felix Lasitschka, Matthias Karck, Gábor Szabó
BACKGROUND: Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). We hypothesized that the preservation of donor hearts with a CM would protect the graft from IRI after prolonged storage in 15-month-old rats and investigated mRNA changes attributable to CM...
December 6, 2018: Journal of Heart and Lung Transplantation
R Peter Alston, Michael Connelly, Christopher MacKenzie, George Just, Natalie Homer
BACKGROUND: Administering isoflurane 2.5% into the oxygenator during cardiopulmonary bypass results in no patient movement. However, doing so may result in an excessive depth of anaesthesia particularly, when hypothermia is induced. Bispectral index and arterial blood and oxygenator exhaust concentrations of volatile anaesthetics should be related to depth of anaesthesia. The primary aim of this study was to measure the depth of anaesthesia using bispectral index, resulting from administering isoflurane 2...
January 12, 2019: Perfusion
Patrik Persson, Angelica Fasching, Fredrik Palm
AIM: Common kidney alterations early after the onset of insulinopenic diabetes include glomerular hyperfiltration, increased oxygen consumption and tissue hypoxia. Increased activity of the renin-angiotensin-aldosterone system (RAAS) has been implicated in most of these early alterations. The RAAS peptide angiotensin (1-7) has the potential to modulate RAAS-mediated alterations in kidney function. Thus, the aim of the present study was to determine the acute effects of angiotensin (1-7) in the kidney of insulinopenic type 1 diabetic rat and the results compared to that of normoglycaemic controls...
January 11, 2019: Acta Physiologica
Seock-Won Youn, Yang Li, Young-Mee Kim, Varadarajan Sudhahar, Kareem Abdelsaid, Ha Won Kim, Yutao Liu, David J R Fulton, Muhammad Ashraf, Yaoliang Tang, Tohru Fukai, Masuko Ushio-Fukai
Myocardial infarction (MI) is the primary cause of cardiovascular mortality, and therapeutic strategies to prevent or mitigate the consequences of MI are a high priority. Cardiac progenitor cells (CPCs) have been used to treat cardiac injury post-MI, and despite poor engraftment, they have been shown to inhibit apoptosis and to promote angiogenesis through poorly understood paracrine effects. We previously reported that the direct injection of exosomes derived from CPCs (CPCexo) into mouse hearts provides protection against apoptosis in a model of acute ischemia/reperfusion injury...
January 10, 2019: Antioxidants (Basel, Switzerland)
Michelle E LeBlanc, Weiwen Wang, Yanli Ji, Hong Tian, Dachuan Liu, Xuxiang Zhang, Wei Li
Wet age-related macular degeneration (AMD) with choroidal neovascularization (CNV) is a leading cause of vision loss in the elderly. The advent of anti-vascular endothelial growth factor (VEGF) drugs represents a major breakthrough in wet AMD therapy but with limited efficacy to improve visual acuity. Secretogranin III (Scg3, SgIII) was recently discovered as a novel angiogenic factor with VEGF-independent mechanisms. Scg3-neutralizing monoclonal antibody (mAb) was reported to alleviate pathological retinal neovascularization in oxygen-induced retinopathy mice and retinal vascular leakage in diabetic mice with high efficacy and disease selectivity...
January 8, 2019: Experimental Eye Research
Kyle M Burk, Derek J Sakata, Kai Kuck, Joseph A Orr
BACKGROUND: Supplemental oxygen is administered during procedural sedation to prevent hypoxemia. Continuous flow oxygen, the most widespread method, is generally adequate but distorts capnography. Pulsed flow oxygen is novel and ideally will not distort capnography. We have developed a prototype oxygen administration system designed to try to facilitate end-tidal carbon dioxide (ETCO2) measurement. We conducted a volunteer study (, NCT02886312) to determine how much nasal ETCO2 measurements vary with oxygen flow rate...
January 8, 2019: Anesthesia and Analgesia
P Rostin, B J Teja, S Friedrich, S Shaefi, K R Murugappan, S K Ramachandran, T T Houle, M Eikermann
It is unclear which criteria should be used to define readiness for tracheal extubation in the operating theatre. We studied the effects of desaturation in the operating theatre immediately after tracheal extubation on long-term outcomes. Performing a pre-specified, retrospective analysis of 71,025 cases involving previously independent adults undergoing non-cardiac surgery, we evaluated the association between desaturation events (oxygen saturation < 90%) within 10 min of tracheal extubation and adverse discharge (to a skilled nursing facility or long-term care facility)...
January 10, 2019: Anaesthesia
Naoyuki Kamatani, Akifumi Kushiyama, Licht Toyo-Oka, Teruhiko Toyo-Oka
Since mitochondria are energy-generating micro-organisms, most of the disorders in patients with mitochondrial diseases (mt-disease) are considered secondary to defects in ATP synthesis, although some other factors such as reactive oxygen species may be involved. A simultaneous oral administration of febuxostat and inosine was reported to elevate both hypoxanthine and ATP levels in peripheral blood. Based on those results, we attempted co-administration of febuxostat and inosine in two patients with mitochondrial disease: one patient with mitochondrial cardiomyopathy and the other patient with mitochondrial diabetes...
January 10, 2019: Journal of Human Genetics
Matthew W Semler, David R Janz, Jonathan D Casey, Wesley H Self, Todd W Rice
RATIONALE: The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. OBJECTIVES: To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. METHODS: In a single-center phase II/III randomized trial, we enrolled adults with suspected infection, ≥2 systemic inflammatory response syndrome criteria, and either shock (mean arterial pressure <60 mm Hg or vasopressors) or respiratory insufficiency (mechanical ventilation or oxygen saturation <97% and fraction of inspired oxygen ≥0...
January 10, 2019: Journal of Intensive Care Medicine
Chunyan Wang, Yang Liu, Yao Wang, Zhijian Wei, Dongmei Suo, Guangzhi Ning, Qiuli Wu, Shiqing Feng, Chunxiao Wan
Low‑frequency pulsed electromagnetic fields (LPEMFs) have been reported to be protective for multiple diseases. However, whether the administration of LPEMFs inhibits inflammation and oxidative stress following spinal cord injury requires further investigation. In the current study, a contusion spinal cord injury model was used and LPEMFs administration was applied to investigate the molecular changes, including inflammation, oxidative stress and heat shock protein 70 (HSP70) levels. The results revealed that LPEMFs significantly promoted functional recovery following spinal cord injury, as demonstrated by an increased Basso, Beattie and Bresnahan score...
January 4, 2019: Molecular Medicine Reports
Shan-Shan Meng, Wei Chang, Zhong-Hua Lu, Jian-Feng Xie, Hai-Bo Qiu, Yi Yang, Feng-Mei Guo
INTRODUCTION: Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effect of surfactant administration on outcomes of adult patients with acute respiratory distress syndrome. METHODS: PubMed, EMBASE, Medline, Cochrane database, Elsevier, Web of Science and were searched and investigated until December 2017...
January 9, 2019: BMC Pulmonary Medicine
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