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Resveratrol

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https://www.readbyqxmd.com/read/28748416/cryoprotective-effect-of-resveratrol-on-dna-damage-and-crucial-human-sperm-messenger-rnas-possibly-through-5-amp-activated-protein-kinase-activation
#1
Maryam Shabani Nashtaei, Saeid Nekoonam, Mohammad Naji, Shabnam Bakhshalizadeh, Fardin Amidi
This work aimed at investigating the effect of resveratrol on (1) DNA integrity and (2) fertilizing capacity of sperm by quantifying the presence of key paternal transcripts considered as markers for male fertility (protamine 1 [PRM1] and protamine 2 [PRM2]) and pregnancy success (adducin 1 alpha [ADD1]) in cryopreserved human spermatozoa through modulation of AMP-activated protein kinase (AMPK). The study populations was drawn from 22 normozoospermic healthy volunteers which were incubated with or without AMPK activator (resveratrol [RSV], 15 µM) or inhibitor (Compound C [CC], 30 µM) for 1 h and were then cryopreserved...
July 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28748373/novel-combination-of-salinomycin-and-resveratrol-synergistically-enhances-the-anti-proliferative-and-pro-apoptotic-effects-on-human-breast-cancer-cells
#2
Jayant Dewangan, Divya Tandon, Sonal Srivastava, Ajeet Kumar Verma, Ashok Yapuri, Srikanta Kumar Rath
Resveratrol (RES) is a natural polyphenol having anti-proliferative activity against breast cancer cells. RES in combination with other chemo modulatory agents, minimizes toxicity and increases efficacy of the treatment. Salinomycin (SAL), a monocarboxylic polyether ionophore is known for selectively targeting breast cancer stem cells. Purpose of the present study was to investigate whether RES in combination with SAL exerts synergistic anti-proliferative activity on breast cancer cells. We further evaluated the molecular mechanism behind SAL and RES mediated cell death...
July 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28747009/pilot-scale-repeated-fed-batch-fermentation-processes-of-the-wine-yeast-dekkera-bruxellensis-for-mass-production-of-resveratrol-from-polygonum-cuspidatum
#3
Hsiao-Ping Kuo, Reuben Wang, Yi-Sheng Lin, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang
Resveratrol has long been used as an ingredient in functional foods. Currently, Polygonum cuspidatum extract is the greatest natural source for resveratrol because of high concentrations of glycosidic-linked resveratrol. Thus, developing a cost-effective procedure to hydrolyze glucoside could substantially enhance resveratrol production from P. cuspidatum. This study selected Dekkera bruxellensis from several microorganisms based on its bioconversion and enzyme-specific activities. We demonstrated that the cells could be reused at least nine times while maintaining an average of 180...
July 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28745768/the-sos-chromotest-applied-for-screening-plant-antigenotoxic-agents-against-ultraviolet-radiation
#4
J L Fuentes, A García Forero, N Quintero Ruiz, C A Prada Medina, N Rey Castellanos, D A Franco Niño, D A Contreras García, Y Córdoba Campo, E E Stashenko
In this work, we investigated the usefulness of the SOS Chromotest for screening plant antigenotoxic agents against ultraviolet radiation (UV). Fifty Colombian plant extracts obtained by supercritical fluid (CO2) extraction, twelve plant extract constituents (apigenin, carvacrol, β-caryophyllene, 1,8-cineole, citral, p-cymene, geraniol, naringenin, pinocembrin, quercetin, squalene, and thymol) and five standard antioxidant and/or photoprotective agents (curcumin, epigallocatechin gallate, resveratrol, α-tocopherol, and Trolox®) were evaluated for their genotoxicity and antigenotoxicity against UV using the SOS Chromotest...
July 26, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28745229/delivering-resveratrol-on-the-buccal-mucosa-using-mucoadhesive-tablets-a-potential-treatment-strategy-for-inflammatory-oral-lesions
#5
Isadora Conde Ferreira Martins, Nádia Rezende Barbosa Raposo, Hanny Reis Mockdeci, Hudson Caetano Polonini, Anderson de Oliveira Ferreira, Gisele Maria Campos Fabri, Maria das Graças Afonso Miranda Chaves
Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. We observed that the tablet with a lower percentage of viscosity agents delivered more resveratrol, although a large amount of the drug was found retained within the stratum corneum...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28744755/resveratrol-protects-against-vacuous-chewing-movements-induced-by-chronic-treatment-with-fluphenazine
#6
Alcindo Busanello, Caroline Queiroz Leal, Luis Ricardo Peroza, Jivago Röpke, Elizete de Moraes Reis, Catiuscia Molz de Freitas, Milena Libardoni, Nilda Berenice de Vargas Barbosa, Roselei Fachinetto
Typical antipsychotics, which are commonly used to treat schizophrenia, cause motor disorders such as tardive dyskinesia (TD) in humans and orofacial dyskinesia (OD) in rodents. The disease mechanisms as well as treatment effectiveness are still unknown. In this study, we investigated the effect of resveratrol, a polyphenol with neuroprotective properties, on behavioral changes induced by chronic treatment with fluphenazine in rats and the possible relationship between monoamine oxidase (MAO) activity and vacuous chewing movements (VCMs)...
July 25, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28744004/sirt1-negatively-regulates-fc%C3%AE%C2%B5ri-mediated-mast-cell-activation-through-ampk-and-ptp1b-dependent-processes
#7
Xian Li, Youn Ju Lee, Fansi Jin, Young Na Park, Yifeng Deng, Youra Kang, Ju Hye Yang, Jae-Hoon Chang, Dong-Young Kim, Jung-Ae Kim, Young-Chae Chang, Hyun-Jeong Ko, Cheorl-Ho Kim, Makoto Murakami, Hyeun Wook Chang
Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation of allergic reactions, although the underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation and anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) and protein tyrosine phosphatase 1B (PTP1B). Mast cell-specific knockout of Sirt1 dampened AMPK-dependent suppression of FcεRI signaling, thereby augmenting mast cell activation both in vitro and in vivo...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28741661/effect-of-dietary-resveratrol-supplementation-on-meat-quality-muscle-antioxidative-capacity-and-mitochondrial-biogenesis-of-broilers
#8
Cheng Zhang, Lei Yang, Xiaohui Zhao, Xingyong Chen, Li Wang, Zhaoyu Geng
BACKGROUND: The naturally occurring polyphenol resveratrol has been acknowledged with many beneficial biological effects. The aim of this study was to evaluate the influence of dietary resveratrol supplementation on meat quality, muscle antioxidative capacity and mitochondrial biogenesis of broilers. One hundred and eighty 21-d-old male Cobb broilers were randomly assigned to two groups and fed on a 0 mg kg(-1) or 400 mg kg(-1) resveratrol-supplemented diet for 21 d. Then, chickens were slaughtered and pectoralis major muscle (PM) samples were collected for analysis...
July 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28739690/nicotine-exposure-augments-renal-toxicity-of-5-aza-cytidine-through-p66shc-prevention-by-resveratrol
#9
Istvan Arany, Samuel Hall, Amir Faisal, Mehul Dixit
BACKGROUND/AIM: We have shown that either chronic nicotine (NIC) exposure or 5-aza-cytidine (AZA) augments oxidative stress-dependent injury through stimulating p66shc in renal cells. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. MATERIALS AND METHODS: Renal proximal tubule cells (NRK52E) were treated with 20 μM RES prior to 200 μM NIC plus 100 nM AZA and cell injury (LDH release) was determined...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738770/effects-of-resveratrol-and-other-polyphenols-on-the-most-common-brain-age-related-diseases
#10
Fiorella Sarubbo, David Moranta, Victor Jose Asensio, Antonio Miralles, Susana Esteban
With the global increase in the elderly population, modern societies must meet the challenge to find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Over the last two decades, oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. As a suggested treatment, the consumption or administration of antioxidant and anti-inflammatory molecules, such as polyphenols, present in food, is recommended as a beneficial strategy for preventing brain aging and several brain age-related diseases...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28738536/effect-of-apigenin-kaempferol-and-resveratrol-on-the-gene-expression-and-protein-secretion-of-tumor-necrosis-factor-alpha-tnf-%C3%AE-and-interleukin-10-il-10-in-raw-264-7-macrophages
#11
Marta Palacz-Wrobel, Paulina Borkowska, Monika Paul-Samojedny, Malgorzata Kowalczyk, Anna Fila-Danilow, Renata Suchanek-Raif, Jan Kowalski
Polyphenols such as apigenin, kaempferol or resveratrol are typically found in plants, including fruits, vegetables, herbs and spices, which have a wide range of biological functions such as antioxidative, anti-inflammatory, vasodilative, anticoagulative and proapoptotic. Discovering such multifunctional compounds in widely consumed plant-based products - ones that both inhibit the release of TNF-α from tissue macrophages and at the same time enhance the secretion of IL-10 - would be an important signpost in the quest for effective pharmacological treatment of numerous diseases that have an inflammatory etiology...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28736128/the-effect-of-pro-nanolipospheres-pnl-formulation-containing-natural-absorption-enhancers-on-the-oral-bioavailability-of-delta-9-tetrahydrocannabinol-thc-and-cannabidiol-cbd-in-a-rat-model
#12
Irina Cherniakov, Dvora Izgelov, Abraham J Domb, Amnon Hoffman
The lipophilic phytocannabinoids cannabidiol (CBD) and Δ(9)-tetrahydrocannabinol (THC) show therapeutic efficacy in various medical conditions. Both molecules are poorly water soluble and subjected to extensive first pass metabolism in the gastrointestinal tract, leading to a limited oral bioavailability of approximately 9%. We have developed an advanced lipid based Self-Emulsifying Drug Delivery System termed Advanced Pro-NanoLiposphere (PNL) pre-concentrate. The PNL is composed of lipid and emulsifying excipients of GRAS status and are known to increase solubility and reduce Phase I metabolism of lipophilic active compounds...
July 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28736027/suppression-of-delayed-xenograft-rejection-by-resveratrol-in-a-hamster-to-rat-cardiac-transplantation-model
#13
Y Lian, C Gao, Y Wu, J Xia, Y Leng, Y Liu, M Zhu, J Chen, Z Qi
BACKGROUND: Delayed xenograft rejection (DXR) is an insurmountable barrier for xenotransplantation. Previous studies reported that hamster hearts transplanted into rats undergo DXR and stop functioning after the cessation of immunosuppression. Herein, we investigated the effects of resveratrol on preventing DXR in a hamster-to-rat vascularized cardiac xenograft model. METHODS: Hamster hearts were engrafted into Lewis rat recipients. Recipient rats received a graft acceptance-inducing treatment of leflunomide and FK506 for 2 weeks to prevent acute xenograft rejection (AXR)...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735861/protective-role-of-benzoselenophene-derivatives-of-resveratrol-on-the-induced-oxidative-stress-in-intestinal-myofibroblasts-and-osteocytes
#14
Vladana Domazetovic, Filippo Fontani, Damiano Tanini, Veronica D'Esopo, Caterina Viglianisi, Gemma Marcucci, Lucia Panzella, Alessandra Napolitano, Maria Luisa Brandi, Antonella Capperucci, Stefano Menichetti, Maria Teresa Vincenzini, Teresa Iantomasi
Resveratrol (RE), a polyphenolic compound present in some food and plants, is characterized by anti-inflammatory and antioxidant properties. However, it is quickly metabolized with consequent loss of its efficacy. In this study, the antioxidant effect of 2-phenyl-benzoselenophene derivatives (VD0, VD1 and VD3) was detected in intestinal myofibroblast and osteocyte cell lines in which the oxidative stress was induced by GSH depletion or starvation, respectively. In fact, the oxidative stress is involved in pathogenesis of inflammatory bowel diseases (IBD) and in increased osteoclastogenesis in osteoporosis...
July 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28735008/trehalose-induced-structural-modulation-of-bovine-serum-albumin-at-ambient-temperature
#15
Ahana Das, Pijush Basak, Rudradip Pattanayak, Turban Kar, Rajib Majumder, Debadrita Pal, Anindita Bhattacharya, Maitree Bhattacharyya, Samudra Prosad Banik
Trehalose is a well-known protein stabilizing osmolyte. The present study has been designed to understand the interaction of trehalose with BSA at ambient temperature. Steady state fluorescence and life-time analysis along with CD, DLS and ITC have been employed to show that trehalose causes surface-associated structural perturbation of BSA to promote its compaction. Trehalose at 0.1M concentration resulted in increased solvent exposure of one of the two tryptophans of BSA with a 5nm redshift in emission and enhanced susceptibility to acrylamide quenching with an increase in KSV from 2...
July 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#16
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
July 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28733146/resveratrol-efficiently-improves-pulmonary-function-via-stabilizing-mast-cells-in-a-rat-intestinal-injury-model
#17
Xiaolei Huang, Weicheng Zhao, Dan Hu, Xue Han, Hanbin Wang, Jianyu Yang, Yang Xu, Yuantao Li, Weifeng Yao, Chaojin Chen
BACKGROUND: Intestinal ischemia/reperfusion (IIR) leads to acute lung injury (ALI) distally by aggravating pulmonary oxidative stress. Resveratrol is effective in attenuating ALI through its antioxidant capacity. This study aimed to determine the effects of resveratrol on IIR-induced ALI and to explore the role of mast cells (MCs) activation in a rat model of IIR. METHODS: Adult Sprague-Dawley rats were subjected to IIR by occluding the superior mesenteric artery for 60min followed by 4-hour reperfusion...
July 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/28732359/resveratrol-inhibits-age-dependent-spontaneous-tumorigenesis-by-sirt1-mediated-post-translational-modulations-in-the-annual-fish-nothobranchius-guentheri
#18
Tingting Liu, Long Ma, Zhaodi Zheng, Fenglin Li, Shan Liu, Yingbo Xie, Guorong Li
Resveratrol, SIRT1 activator, inhibits carcinogenesis predominantly performed in transgenic animal models, orthotopic cancers of nude mice or different cancer cell lines, but its effects during process of spontaneous tumors using vertebrate models remain untested. Spontaneous liver neoplasm is an age-related disease and is inhibited by resveratrol in the annual fish Nothobranchius guentheri, which indicates that the fish can act as an excellent model to study spontaneous tumorigenesis. Totally, 175 fish were fed with resveratrol and another 175 fish for controls...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730834/resveratrol-alleviates-ethanol-induced-hormonal-and-metabolic-disturbances-in-the-rat
#19
J Popelář, M Díaz Gómez, J Lindovský, N Rybalko, J Burianová, T Oohashi, J Syka
Brain-specific link protein Bral2 represents a substantial component of perineuronal nets (PNNs) enwrapping neurons in the central nervous system. To elucidate the role of Bral2 in auditory signal processing, the hearing function in knockout Bral2(-/-) (KO) mice was investigated using behavioral and electrophysiological methods and compared with wild type Bral2(+/+) (WT) mice. The amplitudes of the acoustic startle reflex (ASR) and the efficiency of the prepulse inhibition of ASR (PPI of ASR), produced by prepulse noise stimulus or gap in continuous noise, was similar in 2-week-old WT and KO mice...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28729062/pharmacological-activation-of-ampk-inhibits-incision-evoked-mechanical-hypersensitivity-and-the-development-of-hyperalgesic-priming-in-mice
#20
Michael D Burton, Dipti V Tillu, Khadijah Mazhar, Galo L Mejia, Marina N Asiedu, Kufreobong Inyang, Travis Hughes, Bo Lian, Gregory Dussor, Theodore J Price
New therapeutics to manage post-surgical pain are needed to mitigate the liabilities of opioid and other analgesics. Our previous work shows that key modulators of excitability in peripheral nociceptors, such as extracellular signal-regulated kinases (ERK) are inhibited by activation of adenosine monophosphate activated protein kinase (AMPK). We hypothesized that AMPK activation would attenuate acute incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming caused by surgery in mice...
July 17, 2017: Neuroscience
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