keyword
MENU ▼
Read by QxMD icon Read
search

Resveratrol

keyword
https://www.readbyqxmd.com/read/29778389/resveratrol-improves-in-vitro-maturation-of-oocytes-in-aged-mice-and-humans
#1
Mei-Ju Liu, Ai-Gang Sun, Shi-Gang Zhao, Hui Liu, Shui-Ying Ma, Mei Li, Ying-Xue Huai, Han Zhao, Hong-Bin Liu
OBJECTIVE: To evaluate the effects of resveratrol on oocyte maturation in aged mice and humans. DESIGN: Experimental laboratory study. SETTING: University-based reproductive medicine center. PATIENT(S): A total of 64 women 38-45 years of age undergoing intracytoplasmic sperm injection (ICSI) and 48-52-week-old female C57BL/6J mice. INTERVENTION(S): In vitro culture in the presence of three different concentrations of resveratrol (0...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29775898/particle-induced-sirt1-downregulation-promotes-osteoclastogenesis-and-osteolysis-through-er-stress-regulation
#2
Liang Zhang, Dongmei Bao, Peng Li, Zhidong Lu, Long Pang, Zhirong Chen, Haohui Guo, Zhihui Gao, Qunhua Jin
BACKGROUND: Sirtuin 1 (SIRT1) downregulation has been found to be induced by wear particles in aseptic prosthesis loosening (APL). Osteoclastogenesis and osteoclast activation are the main pathological factors associated with APL. However, whether SIRT1 downregulation contributes to the formation and activation of osteoclasts through the induction of endoplasmic reticulum (ER) stress is unclear. METHODS: To address this, an osteolysis mouse model was used in which animals were treated with the SIRT1 activator, resveratrol (RES), or an ER stress inhibitor, 4-PBA, for two weeks...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29770579/cholinesterase-targeting-by-polyphenols-a-therapeutic-approach-for-the-treatment-of-alzheimer-s-disease
#3
REVIEW
Nasimudeen R Jabir, Fayaz Rahman Khan, Shams Tabrez
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29769094/screening-of-melatonin-%C3%AE-tocopherol-folic-acid-acetyl-l-carnitine-and-resveratrol-for-anti-dengue-2-virus-activity
#4
Atchara Paemanee, Atitaya Hitakarun, Sittiruk Roytrakul, Duncan R Smith
OBJECTIVE: Infections with the mosquito transmitted dengue virus (DENV) are a significant public health burden in many parts of the world. Despite the introduction of a commercial vaccine in some parts of the world, the majority of the populations at risk of infection remain unprotected against this disease, and there is currently no treatment for DENV infection. Natural compounds offer the prospect of cheap and sustainable therapeutics to reduce the disease burden during infection, and thus potentially alleviate the risk of more severe disease...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29767332/recent-development-in-antihyperalgesic-effect-of-phytochemicals-anti-inflammatory-and-neuro-modulatory-actions
#5
REVIEW
Ajeet Kumar Singh, Sanjay Kumar, Manjula Vinayak
INTRODUCTION: Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain relievers in present day practice as pain is mostly initiated due to inflammation. However, due to potentially serious side effects, long term use of these antihyperalgesic drugs raises concern. Therefore there is a demand to search novel medicines with least side effects...
May 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29766146/the-effect-of-resveratrol-on-oxidative-stress-in-the-liver-and-serum-of-a-rat-model-of-polycystic-ovary-syndrome-an-experimental-study
#6
Mahnaz Ghowsi, Homayoun Khazali, Sajjad Sisakhtnezhad
Background: Studies of oxidative status in polycystic ovarian syndrome (PCOS) patients are limited with inconsistent results. The effects of resveratrol as a natural antioxidant on oxidative status in PCOS aren't clear. Objective: This study evaluated effects of resveratrol on oxidative stress in the liver and serum of the PCOS rats. Materials and Methods: Fifteen female Wistar rats (3 wk old) were divided into 3 groups (n=5/each e): Control group, PCO-Control group, and PCO-Resveratrol group...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29765509/resveratrol-induced-downregulation-of-naf-1-enhances-the-sensitivity-of-pancreatic-cancer-cells-to-gemcitabine-via-the-ros-nrf2-signaling-pathways
#7
Liang Cheng, Bin Yan, Ke Chen, Zhengdong Jiang, Cancan Zhou, Junyu Cao, Weikun Qian, Jie Li, Liankang Sun, Jiguang Ma, Qingyong Ma, Huanchen Sha
NAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, is known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural polyphenolic compound, is considered as a potent anticancer agent. Nevertheless, the molecular mechanisms underlying the effects of resveratrol and NAF-1 and their mediation of drug resistance in pancreatic cancer remain unclear. Here, we demonstrate that resveratrol suppresses the expression of NAF-1 in pancreatic cancer cells by inducing cellular reactive oxygen species (ROS) accumulation and activating Nrf2 signaling...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29765505/inhibition-of-protein-aggregation-by-several-antioxidants
#8
Samra Hasanbašić, Alma Jahić, Selma Berbić, Magda Tušek Žnidarič, Eva Žerovnik
Amyloid fibril formation is a shared property of all proteins; therefore, model proteins can be used to study this process. We measured protein aggregation of the model amyloid-forming protein stefin B in the presence and absence of several antioxidants. Amyloid fibril formation by stefin B was routinely induced at pH 5 and 10% TFE, at room temperature. The effects of antioxidants NAC, vitamin C, vitamin E, and the three polyphenols resveratrol, quercetin, and curcumin on the kinetics of fibril formation were followed using ThT fluorescence...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29765076/resveratrol-significantly-improves-the-fertilisation-capacity-of-bovine-sex-sorted-semen-by-inhibiting-apoptosis-and-lipid-peroxidation
#9
Chong-Yang Li, Ya-Han Zhao, Hai-Sheng Hao, Hao-Yu Wang, Jin-Ming Huang, Chang-Liang Yan, Wei-Hua Du, Yun-Wei Pang, Pei-Pei Zhang, Yan Liu, Hua-Bin Zhu, Xue-Ming Zhao
The aim of this study was to test the effects of five different concentrations (0, 10-3 , 10-4 , 10-5 , and 10-6  M) of resveratrol (Res) supplementation in bull sperm washing and fertilisation medium on levels of reactive oxygen species (ROS), phosphatidylserine (PS) externalisation, mitochondrial membrane potential (Δψm), ATP and malondialdehyde (MDA), acrosomal integrity, blastocyst rate, and blastocyst quality after in vitro fertilisation (IVF). The results for sex-sorted sperm from three bulls showed: (1) ROS and MDA levels in 10-3  M and 10-4  M Res groups were significantly lower than those of controls (P < 0...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764766/efficient-monooxygenase-catalyzed-piceatannol-production-application-of-cyclodextrins-for-reducing-product-inhibition
#10
Toshiki Furuya, Masahiko Sai, Kuniki Kino
Piceatannol is a rare, costly plant-based stilbene derivative and exhibits various health-enhancing properties. Recently, we demonstrated that piceatannol could be produced from resveratrol through site-selective hydroxylation using Escherichia coli cells expressing the monooxygenase HpaBC. However, piceatannol production ceased at approximately 25 mM, even when sufficient levels of the substrate resveratrol remained in the reaction mixture. In this study, we found that high concentrations (>20-25 mM) of piceatannol significantly inhibited the HpaBC-catalyzed reaction...
May 12, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29762078/resveratrol-promoted-interferon-%C3%AE-induced-growth-inhibition-and-apoptosis-of-smmc7721-cells-by-activating-the-sirt-stat1
#11
Zhanchun Yang, Qingyu Meng, Yuying Zhao, Rui Han, Shishun Huang, Meiqi Li, Xuan Wu, Wenna Cai, Haihe Wang
Interferon-α (IFN-α) resistance is a major hurdle in the treatment of hepatocellular carcinoma (HCC). Signal transducers and activators of transcription 1 (STAT1) play a key role in exerting the antiproliferative and proapoptotic effects of IFN-α on tumors. In this study, we aimed to investigate whether resveratrol can promote IFN-α-induced growth inhibition and the apoptosis on HCC cells through the SIRT/STAT1 pathway. We found that IFN-α induced growth inhibition and apoptosis of SMMC7721 cells, and the effects could be significantly enhanced and blocked by resveratrol and EX527, respectively...
May 15, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29761542/ameliorative-effect-of-resveratrol-on-testicular-oxidative-stress-spermatological-parameters-and-dna-damage-in-glyphosate-based-herbicide-exposed-rats
#12
F Avdatek, Y O Birdane, R Türkmen, H H Demirel
In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20 mg kg-1 daily-1 RES, group III received normal feed containing 375 mg kg-1 daily-1 GLF, and group IV received normal feed containing 375 mg kg-1 daily-1 GLF+20 mg kg-1 daily-1 RES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats...
May 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29758202/mounting-evidence-validates-ursolic-acid-directly-activates-sirt1-a-powerful-stac-which-mimic-endogenous-activator-of-sirt1
#13
Nuredin Bakhtiari, Sako Mirzaie, Roohullah Hemmati, Elham Moslemee-Jalalvand, Ali Reza Noori, Jahanfard Kazemi
Ursolic Acid (UA), a pentacyclic triterpenoid compound, plays a vital role in aging process. However, the role of UA in the regulation of aging and longevity is still controversial as we have previously demonstrated that UA increases SIRT1 protein level in aged-mice. Here, we reveal that UA directly activates SIRT1 in silico, in vitro and in vivo. We have identified that UA binds to outer surface of SIRT1 and leads to tight binding of substrates to enzyme in comparison with Resveratrol (RSV) and control. Furthermore, our results indicate that UA drives the structure of SIRT1 toward a closed state (an active form of enzyme)...
May 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29757003/transglutaminase-2-mediates-the-cytotoxicity-of-resveratrol-in-a-human-cholangiocarcinoma-and-gallbladder-cancer-cell-lines
#14
Leda Roncoroni, Luca Elli, Paola Braidotti, Delfina Tosi, Valentina Vaira, Lorenza Tacchini, Vincenza Lombardo, Federica Branchi, Alice Scricciolo, Luisa Doneda
Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Our aim was to evaluate if the cytotoxic effect of resveratrol (RES) on cholangiocarcinoma (CC) and gallbladder cancer (GBC) cell lines could be abolished by TG2 inhibition. Human CC and GBC cell lines (SK-ChA-1 and MZ-ChA-1), grown in a three-dimensional cell culture system (MCTS, multicellular tumor spheroids), were treated for 72 h with RES (32, 64 µM) alone or combined with different TG2 inhibitors (Cystamine, B003, T101)...
May 14, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29756977/effects-of-red-wine-grape-juice-and-resveratrol-consumption-on-bone-parameters-of-wistar-rats-submitted-to-high-fat-diet-and-physical-training
#15
Letícia Monteiro da Fonseca Cardoso, Nina Da Matta Alvarez Pimenta, Raiza Da Silva Ferreira Fiochi, Bruna Ferreira Mota Mota, Juliana Arruda de Souza Monnerat, Cristiane Correia Teixeira, Renata Beatriz Da Rocha Ramalho, Isabelle Waleska Maldronato, Manuela Dolisnky, Gilson Teles Boaventura, Vilma Blondet, Sergio Girão Barroso, Carlos Alberto Soares da Costa, Gabrielle De Souza Rocha
INTRODUCTION: intake of diets with high saturated fat may produce deleterious effects on bone mineralization. Lifestyle changes help reduce the bone loss observed in osteoporosis. Resveratrol, present in grape juice and red wine, has osteogenic and osteoinductive effects, being potentially beneficial for bone health. OBJECTIVE: to evaluate the effects of red grape juice, red wine and resveratrol consumption on bone parameters in Wistar rats submitted to a high-fat diet and physical training...
October 27, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29755200/capture-and-purification-of-polyphenols-using-functionalized-hydrophobic-resins
#16
Marcelo Silva, Leydi Castellanos, Marcel Ottens
Adsorption can be an effective way of purifying polyphenols from complex mixtures. However, polyphenols may be present in small concentrations, making it difficult to selectively adsorb them onto standard hydrophobic resins and obtain appreciable adsorption. In this work, nonfunctionalized hydrophobic resins (Amberlite XAD-7HP, XAD-16) are compared with functionalized resins with imidazole (Biotage RENSA PX) and pyridine (RENSA PY) in terms of capacity and selectivity toward p -coumaric acid, trans -resveratrol, and naringenin...
April 18, 2018: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/29754265/resveratrol-analogue-e-n-2-4-methoxystyryl-phenyl-furan-2-carboxamide-induces-g-2-m-cell-cycle-arrest-through-the-activation-of-p53-p21-cip1-waf1-in-human-colorectal-hct116-cells
#17
Foo Kit Cheah, Kok Hoong Leong, Noel Francis Thomas, Hui Kee Chin, Azhar Ariffin, Khalijah Awang
Resveratrol, a naturally occurring polyphenolic antioxidant, is a potential chemoprophylactic agent for various cancers, including colorectal cancer. Although emerging evidence continually suggests that a number of resveratrol derivatives may be better cancer chemopreventive candidates than resveratrol, studies on the mechanism of action of these derivatives are limited. This is the first study which investigates the mechanism underlying the cytotoxic effect of a synthesized resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide (CS) on colorectal cancer...
May 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29752339/resveratrol-enhances-matrix-biosynthesis-of-nucleus-pulposus-cells-through-activating-autophagy-via-the-pi3k-akt-pathway-under-oxidative-damage
#18
Jinlou Gao, Qingyun Zhang, Lin Song
BACKGROUND: The decrease in nucleus pulposus (NP) matrix production is a classic  feature during disc degeneration. Resveratrol (RSV) is reported to play protective effects under many pathological factors. OBJECTIVE: This study aims to study the effects of RSV on NP matrix homeostasis under oxidative damage and the potential mechanism. METHODS: Rat NP cells were exposed to H2 O2 solution to create an oxidative damage. RSV and the 3‑Methyladenine (3-MA) was added along with the culture medium to respectively investigate the role of RSV and cellular autophagy...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29751913/does-resveratrol-retain-its-antioxidative-properties-in-wine-redox-behaviour-of-resveratrol-in-the-presence-of-cu-ii-and-tebuconazole
#19
Jana Jaklová Dytrtová, Michal Straka, Kateřina Bělonožníková, Michal Jakl, Helena Ryšlavá
Resveratrol is antioxidant naturally occurring in wine grapes. It is thought to have a preventive biological activity against number of diseases. However, it has been recently shown that in the presence of metal ions, such as Cu2+ , resveratrol forms oxidative radicals. Cu2+ is usually present in wine due to former usage of bluestone in vineyards. Fungicide tebuconazole has substituted bluestone and is presently one of the most widely used agrochemicals in wine industry; wine thus may contain traces of tebuconazole...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29751609/pterostilbene-and-4-methoxyresveratrol-inhibited-lipopolysaccharide-induced-inflammatory-response-in-raw264-7-macrophages
#20
Yun Yao, Kehai Liu, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang
Pterostilbene (Pte) and 4&prime;-Methoxyresveratrol (4MR) are methylated derivatives of resveratrol. We investigated the anti-inflammatory effect of Pte and 4MR in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. Both Pte and 4MR significantly reduced LPS-induced nitric oxide release by inhibiting the inducible nitric oxide synthase mRNA expression. Moreover, both of them inhibited LPS-induced mRNA expression of inflammatory cytokines including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6 and IL-1&beta;, and tumor necrosis factor &alpha; (TNF-&alpha;), and attenuated LPS-induced nuclear factor-&kappa;B (NF-&kappa;B) activation by decreasing p65 phosphorylation...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
10927
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"