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Keiko Fujita, Yoshinao Aoki, Shunji Suzuki
Vitis vinifera cv. Koshu is an indigenous cultivar in Japan and has several characteristics that distinguish it from European V. vinifera. In Japan, Koshu is the most popular cultivar for wine making. We report herein a cell culture established from Koshu for use as a system for the production of resveratrol and its derivatives. Grape cell culture YU-1 was developed from the apex tissues of Koshu. YU-1 growth was favorably compared with BY-2 growth, a standard cell line in plant cell biology. Stilbene production and stilbene synthesis gene expression in YU-1 were upregulated by UV-C irradiation...
March 15, 2018: Cytotechnology
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
Behjat Javadi
Cancer is the second leading cause of death with profound socio-economic consequences worldwide. Growing evidence suggests the crucial role of diet on cancer prevention and treatment. In Traditional Persian Medicine (TPM) there is a major focus on contribution of special diet and foods to cancer management. In the present article, the cytotoxic and antitumor activities of several food items including plants and animal products recommended by TPM as anticancer agents are discussed. Strong evidence supports the anticancer effects of beetroot (Beta vulgris) and its major compound betanin, cinnamon and cinnamaldehyde, barley (H...
March 15, 2018: Nutrition and Cancer
Purabi Sarkar, Ananya Bhowmick, Sofia Banu
Enhanced oxidative stress plays an important role in the progression and onset of diabetes and its complications. Strategies or efforts meant to reduce the oxidative stress are needed which may mitigate these pathogenic processes. The present study aims to investigate the in vitro ameliorative potential of nine antioxidant molecules in L6 myotubes under oxidative stress condition induced by 4-hydroxy-2-nonenal and also to comprehend the gene expression patterns of oxidative stress genes upon the supplementation of different antioxidants in induced stress condition...
March 14, 2018: Cytotechnology
Xuren Gao, Jian Ge, Weiyi Li, Wangchen Zhou, Lei Xu
Background: Resveratrol (RSV) has been reported to stimulate osteoblast differentiation in which Wnt/β-catenin signaling pathway played a crucial role. However, whether and how RSV activated Wnt/β-catenin pathway in osteogenic differentiation still remained elusive. Methods: In vivo polymethylmethacrylate (PMMA) particle-induced osteolysis (PIO) mouse model and in vitro PMMA particle-stimulated mouse mesenchymal stem cells (mMSCs) experiments were established...
2018: Cell & Bioscience
Chunjiang Lv, Yongsheng Zhang, Lili Shen
BACKGROUND: Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated. METHODS: We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18-60 years) with severe persistent AR were divided into a placebo-treated group (n = 50), a positive control budesonide-treated group (n = 50), and a resveratrol-treated group (n = 51)...
March 14, 2018: International Archives of Allergy and Immunology
Michael L Ekaney, Gabrielle Gonzalez Gray, Iain H McKillop, Susan L Evans
BACKGROUND: Limited availability and use of whole blood (WB) following trauma is driven by perceptions that hemostatic function is limited by platelet dysfunction within 5 days storage. We sought to define the hemostatic function of WB stored at 4°C for up to 25 days, elucidate changes in metabolic parameters and mitochondrial dysfunction in platelets in WB, and the effect of supplementation using resveratrol (Res) or cytochrome c (Cyt c). METHODS: WB was collected, aliquoted, and stored at 4°C without agitation...
March 12, 2018: Journal of Trauma and Acute Care Surgery
Chih-Chien Wang, Chih-Hsin Wang, Hsiang-Cheng Chen, Juin-Hong Cherng, Shu-Jen Chang, Yi-Wen Wang, Adrienne Chang, Jue-Zong Yeh, Yi-Huei Huang, Cheng-Che Liu
Repair and regeneration of craniofacial tissues is particularly challenging because they comprise a complex structure of hard and soft tissues involved in intricate functions. This study combined collagen scaffolds and human adipose stem cells (hASCs) for oral mucosal and calvarial bone regeneration by using resveratrol (RSV), which affects the differentiation of mesenchymal stem cells. We have evaluated the effect of collagen scaffold-containing RSV (collagen/RSV) scaffolds both in vitro and in vivo for their wound healing and bone regeneration potential...
March 13, 2018: International Wound Journal
Wen-Jun Yan, Ruo-Bin Liu, Ling-Kai Wang, Ya-Bing Ma, Shao-Li Ding, Fei Deng, Zhong-Yuan Hu, Da-Bin Wang
Endoplasmic reticulum (ER) stress occurring in stringent conditions is critically involved in neuronal survival and death. Resveratrol is a non-flavonoid polyphenol that has neuroprotective effects against many neurological disorders. Here, we investigated the potential protective effects of resveratrol in an in vitro ER stress model mimicked by tunicamycin (TM) treatment in neuronal HT22 cells. We found that TM dose-dependently decreased cell viability and increased apoptosis, which were both significantly attenuated by resveratrol treatment...
2018: Frontiers in Neuroscience
Dong-Dong Shi, Celia M Dong, Leon C Ho, C T W Lam, Xi-Dan Zhou, Ed X Wu, Zhong-Jun Zhou, Xiao-Min Wang, Zhang-Jin Zhang
Chemotherapy-induced cognitive impairment, also known as "chemobrain," is a common side effect. The purpose of this study was to examine whether resveratrol, a natural polyphenol that has nootropic effects, could prevent chemobrain and its underlying mechanisms. Mice received three injections of docetaxel, adriamycin, and cyclophosphamide (DAC) in combination, a common chemotherapy regimen, at two-day intervals within one week. Resveratrol (50 and 100 mg/kg per day) was orally administered for three weeks, beginning one week before the DAC treatment...
March 10, 2018: Neurobiology of Disease
Laura A Calvo-Castro, Christina Schiborr, Franziska David, Heidi Ehrt, Jenny Voggel, Nadine Sus, Dariush Behnam, Anja Bosy-Westphal, Jan Frank
SCOPE: Grapevine-shoot extract Vineatrol® 30 contains abundant resveratrol monomers and oligomers with health-promoting potential. However, the oral bioavailability of these compounds in humans is low (˂1-2%). The aim of this study was to improve the oral bioavailability of resveratrol from vineatrol by micellar solubilization. METHODS AND RESULTS: Twelve healthy volunteers (6 women, 6 men) randomly ingested a single dose of 500 mg vineatrol (30 mg trans-resveratrol, 75 mg trans-ε-viniferin) as native powder or liquid micelles...
March 13, 2018: Molecular Nutrition & Food Research
N Khodaie, N Tajuddin, R M Mitchell, E J Neafsey, M A Collins
Preconditioning brain cultures with moderate concentrations of ethanol (EtOH) or trans-resveratrol (RES), key red wine constituents, can prevent amyloid-β (Aβ) neurotoxicity. Past studies have indicated that moderate EtOH activates synaptic N-methyl-D-aspartate receptors (NMDAR) that, in part, signal via protein kinase C (PKC) to increase protective antioxidant proteins such as peroxiredoxin-2 (Prx2). RES preconditioning also is reported to involve NMDAR and PKC. However, although moderate, the EtOH and RES concentrations used have been noticeably above circulating levels from two glasses of wine, a daily intake linked to reduced risk of cognitive decline among older social drinkers...
March 12, 2018: Neurotoxicity Research
Jin-Wei Zhou, Tong-Tong Chen, Xiao-Juan Tan, Ji-Yang Sheng, Ai-Qun Jia
Pseudomonas aeruginosa infection is a serious disease in cystic fibrosis (CF) patients and is difficult to cure due to biofilm persistence and emerging multidrug resistance. Considering the essential role of quorum sensing (QS) in P. aeruginosa infections, the enhanced effects between quorum sensing inhibitor (QSI) resveratrol and several antibiotics against P. aeruginosa PAO1 were investigated. Crystal violet staining assay revealed that the biofilms of P. aeruginosa PAO1 grown in the presence of resveratrol were more susceptible to aminoglycoside antibiotics...
March 9, 2018: International Journal of Antimicrobial Agents
Alessandro Vannozzi, Darren Chern Jan Wong, Janine Höll, Ibrahim Hmmam, José Tomás Matus, Jochen Bogs, Tobias Ziegler, Ian Dry, Gianni Barcaccia, Margherita Lucchin
Stilbene synthase (STS) is the key enzyme leading to the biosynthesis of resveratrol. Recently we reported two R2R3-MYB transcription factors (TFs) that regulate the stilbene biosynthetic pathway in grapevine: VviMYB14 and VviMYB15. These genes strongly co-express with STSs under a range of stress and developmental conditions, in agreement with the specific activation of STS promoters by these TFs. Genome-wide gene co-expression analysis using two separate transcriptome compendia based on microarray and RNA-Seq data revealed that WRKY TFs were the top TF family correlated with STS genes...
February 26, 2018: Plant & Cell Physiology
M Bilgehan Pektas, Ozge Turan, Gozde Ozturk Bingol, Esra Sumlu, Gökhan Sadi, Fatma Akar
Transient elevations in blood glucose level may lead to changes in vascular function. Herein, we investigated the effects of high-glucose or high-fructose challenge as well as potential influence of juglone or resveratrol on vascular reactivity, Akt/eNOS and insulin signaling effectors in rat aorta. Aortic segments of rats were incubated with high-glucose (30 mM) or high-fructose (2 mM) in the absence and presence of juglone (5 μM) or resveratrol (10 μM). Acute high-glucose incubation markedly decreased acetylcholine-induced relaxation, which is further inhibited by juglone, but ameliorated by resveratrol...
March 10, 2018: Canadian Journal of Physiology and Pharmacology
Wei Liu, Qi Zhao, Luyang Lv, Suo Yan, Qin Song, Tian Chen, Qian Yao
Pomegranate seed oil (PSO) is primarily composed of unsaturated fatty acids, implying its potential application as a transdermal enhancer. In this study, the function of PSO in prompting the percutaneous absorption of resveratrol was examined and compared with isopropyl palmitate (IP). IP of 10% enhanced the cumulative permeation amount of resveratrol by 50% but did not influence the permeation velocity. Though 2.5% and 5.0% IP accelerated the penetration process of resveratrol, they had no discernable impact on total permeation amount...
March 9, 2018: Journal of Oleo Science
S Jahan, D Kumar, S Singh, V Kumar, A Srivastava, A Pandey, C S Rajpurohit, V K Khanna, A B Pant
The role of resveratrol (RV) as a neuroprotectant is well recognized, and cellular molecules involved in imparting the physiological effect have been well illustrated. However, some ambiguity still prevails as the specific receptor, and downstream signaling molecules are not yet clearly stated. So, we investigated the signaling pathway(s) involved in its cellular protection in the human umbilical cord blood mesenchymal stem cell (hUCB-MSC) derived neuronal cells. The mesenchymal stem cells were exposed to various concentrations (10, 100, 1000 μM) of monocrotophos (MCP), a known developmental neurotoxic organophosphate pesticide, for a period of 24 h...
March 10, 2018: Molecular Neurobiology
Ying Liu, HongNa Yang, GuoYong Jia, Lan Li, Hui Chen, JianZhong Bi, CuiLan Wang
BACKGROUND: It is well accepted that both rosuvastatin and resveratrol exert neuroprotective effects on cerebral ischemia/reperfusion injury through some common pathways. Resveratrol has also been demonstrated to protect against cerebral ischemia/reperfusion injury through enhancing autophagy. Thus, we hypothesized that combined rosuvastatin and resveratrol pretreatment had synergistic effects on cerebral ischemia/reperfusion injury. MATERIALS AND METHODS: Adult male Sprague Dawley rats receiving middle cerebral artery occlusion surgery as animal model of cerebral ischemia/reperfusion injury were randomly assigned to 4 groups: control, resveratrol alone pretreatment, rosuvastatin alone pretreatment, and combined rosuvastatin and resveratrol pretreatment...
March 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Maryam Safahani, Hadi Aligholi, Farshid Noorbakhsh, Mahmoud Djalali, Hamideh Pishva, Sayed Mostafa Modarres Mousavi, Fatemeh Alipour, Ali Gorji, Fariba Koohdani
OBJECTIVE: Adult hypothalamic neurogenesis has been considered a central regulator of energy balance. Resveratrol (RSV), a natural polyphenol, influences the body fat mass and reduces the amount of adipose tissue. The present study was designed to evaluate the effect of RSV on dynamic of hypothalamic neurons in a diet-induced obesity model of mice. METHODS: Apoptosis, neurogenesis, the expression of the main trophic factors, and the fate of newborn cells were evaluated in the hypothalamus of adult male C57 BL/6 J mice fed a normal diet, a high-fat (HF) diet, or an HF diet supplemented with 400 mg/kg RSV (HF + RSV) for 6 wk...
December 2, 2017: Nutrition
Dubravka Rašić, Marin Mladinić, Davor Želježić, Alica Pizent, Srđan Stefanović, Dragan Milićević, Paško Konjevoda, Maja Peraica
A multimycotoxin analysis approach in grains results in frequent simultaneous findings of nephrotoxic mycotoxins ochratoxin A (OTA) and citrinin (CTN). The mechanism of CTN and OTA toxicities in biological systems is not fully understood but it is known that oxidative stress is involved. In this study, oxidative damage of DNA, lipids, and the concentration of glutathione (GSH), as well as possible antioxidative effects of resveratrol (RSV) were studied in vivo. Male adult Wistar rats were treated orally with OTA (0...
March 7, 2018: Toxicon: Official Journal of the International Society on Toxinology
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