Lingyu Ruan, Mengyun Zheng, Xinru Xia, Chaofan Pang, Yating Wang, Zhiwei Fan, Jingtian Yang, Qing Qing, Hongyan Lin, Yuheng Tao, Junsong Wang, Liqun Wang
Polygonum multiflorum Thunb. (PMT) has shown promise in exerting cerebrovascular protective effects, and its potential for treating ischemic stroke (IS) has garnered attention. However, the lack of clarity regarding its chemical constituents and mechanisms has significantly hindered its clinical application. In this study, we employed network pharmacology and molecular docking techniques for the first time to elucidate the potential compounds and targets of PMT in treating IS. The databases CTD, DrugBank, DisGeNET, GeneCards, OMIM, TTD, PGKB, NCBI, TCMIP, CNKI, PubMed, ZINC, STITCH, BATMAN, ETCM and Swiss provided information on targets related to IS and components of PMT, along with their associated targets...
April 15, 2024: Combinatorial Chemistry & High Throughput Screening