keyword
MENU ▼
Read by QxMD icon Read
search

Placenta obesity

keyword
https://www.readbyqxmd.com/read/28443479/melatonin-improves-mitochondrial-respiration-in-syncytiotrophoblasts-from-placentas-of-obese-women
#1
Kayla E Ireland, Alina Maloyan, Leslie Myatt
Maternal obesity is associated with increased oxidative stress but decreased placental mitochondrial respiration and expression of mitochondrial electron transport chain (ETC) complexes I to V. Melatonin acts as an antioxidant and prevents oxidative stress-induced changes in cytotrophoblasts. Placentas were collected at term by cesarean delivery from obese (first trimester body mass index [BMI] ≥30, n = 10) or lean (BMI < 25, n = 6) women. Cytotrophoblasts were isolated and allowed to syncytialize for 72 hours with or without melatonin (0...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28426649/the-importance-of-appropriate-initial-bacterial-colonization-of-the-intestine-in-newborn-child-and-adult-health
#2
REVIEW
W Allan Walker
The fetus does not reside in a sterile intrauterine environment and is exposed to commensal bacteria from the maternal gut/blood stream which crosses the placenta and enters the amniotic fluid. This intestinal exposure to colonizing bacteria continues at birth and during the first year of life and has a profound influence on lifelong health. Why is this important? Intestinal crosstalk with colonizing bacteria in the developing intestine affects the infant's adaptation to extrauterine life (immune homeostasis) and provides protection against disease expression (allergy, autoimmune disease, obesity, etc...
April 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28368446/dysregulation-of-placental-mirna-in-maternal-obesity-is-associated-with-pre-and-post-natal-growth
#3
Gemma Carreras-Badosa, Alexandra Bonmatí, Francisco-Jose Ortega, Josep-Maria Mercader, Marta Guindo-Martínez, David Torrents, Anna Prats-Puig, Jose-Maria Martinez-Calcerrada, Francis DE Zegher, Lourdes Ibáñez, Jose-Manuel Fernandez-Real, Abel Lopez-Bermejo, Judit Bassols
Context: Human placenta exhibits a specific miRNA expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders like preeclampsia and intrauterine growth restriction, and are potential biomarkers for these pathologies. Objective: To study the placental miRNA profile in pregnant women with pregestational (preOB) or gestational obesity (gestOB) and explore the associations of placental miRNAs dysregulated in maternal obesity with pre- and post-natal growth...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28346921/bacterial-colonization-of-the-newborn-gut-immune-development-and-prevention-of-disease
#4
W Allan Walker
We now know that the fetus does not reside in a sterile intrauterine environment but is exposed to commensal bacteria from the maternal gut which cross the placenta and infiltrate the amniotic fluid. This exposure to colonizing bacteria continues at birth and during the first year of life, and it has a profound influence on lifelong health. Why is this important? Cross talk with colonizing bacteria in the developing neonatal intestine helps in the initial adaptation of the infant to extrauterine life, particularly in acquiring immune homeostasis, and provides protection against disease expression (e...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346919/the-pregnancy-microbiome
#5
Hadar Neuman, Omry Koren
In recent years, microbiome research has revealed multiple essential roles of the microorganisms residing within the human body in host metabolism, immunity, and overall health. Numerous physiological and pathological states, including obesity and the metabolic syndrome, have been correlated with microbial changes, termed dysbiosis. Our microbiomes change in response to our environment, diet, weight, hormones, and other factors. It is, therefore, not surprising that there are also significant changes in the microbiome during pregnancy when dramatic weight gain and metabolic and immunological changes occur...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28315860/determinants-and-duration-of-impact-of-early-gut-bacterial-colonization
#6
Christine Ann Edwards
BACKGROUND: An increasing number of studies show low diversity of the gut microbiome in those with chronic diseases such as obesity, inflammatory bowel disease, and allergy. Manipulation of the microbiota may promote health. However, the adult microbiota is stable and may be difficult to change. Understanding the fixed and modifiable factors, which determine colonization in early life, may provide strategies for acquisition of a health-promoting microbiome. SUMMARY: Not enough is known about the long-term effects of established determinants of gut colonization, including delivery mode, perinatal antibiotics, and infant diet...
March 18, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28301855/placental-lipid-and-fatty-acid-transfer-in-maternal-overnutrition
#7
Rohan M Lewis, Gernot Desoye
BACKGROUND: The increasing incidence of childhood obesity is a significant public health challenge, the consequences of which extend across the life course. SUMMARY: Diet and exercise are clearly the major contributors to childhood obesity, but the factors predisposing to obesity may become established in the womb. Worryingly maternal overnutrition, in particular when it leads to obesity and diabetes, perpetuate an intergenerational cycle of obesity through its effects on placental function and fetal metabolism...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28301844/the-placenta-maternal-diet-and-adipose-tissue-development-in-the-newborn
#8
Michael E Symonds, Ian Bloor, Shalini Ojha, Helen Budge
BACKGROUND: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other organ in the body. The extent to which maternal obesity and/or an obesogenic diet impacts on placental function thereby resetting the relative distribution of different types of fat in the fetus is unknown. SUMMARY: Developmentally the majority (if not all) fat in the fetus can be considered as classical brown fat, in which UCP1 is highly abundant...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28292470/sexual-dimorphism-in-the-effect-of-maternal-obesity-on-antioxidant-defense-mechanisms-in-the-human-placenta
#9
LaShauna Evans, Leslie Myatt
INTRODUCTION: Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal sex on pro- and anti-oxidant status in placenta and placental mitochondria. METHODS: Placental villous tissue was collected at term via c-section prior to labor from four groups of patients based on fetal sex and prepregnancy/1st trimester body mass index: lean - BMI 22...
March 2017: Placenta
https://www.readbyqxmd.com/read/28292465/lipopolysaccharide-and-double-stranded-viral-rna-mediate-insulin-resistance-and-increase-system-a-amino-acid-transport-in-human-trophoblast-cells-in%C3%A2-vitro
#10
Stella Liong, Martha Lappas
INTRODUCTION: Inflammation and underlying low-grade maternal infection can impair insulin signalling and upregulate nutrient transport in the placenta which contribute to fetal overgrowth associated with GDM and/or obese pregnancies. There are, however, no studies on the role of infection on placental nutrient transport in pregnancies complicated by GDM and/or obesity. Thus, the aims of this study were to determine the effect of the bacterial product lipopolysaccharide (LPS) or the viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on the insulin signalling pathway and amino acid transport in primary human trophoblast cells...
March 2017: Placenta
https://www.readbyqxmd.com/read/28285098/role-of-leptin-as-a-link-between-metabolism-and-the-immune-system
#11
REVIEW
Antonio Pérez-Pérez, Teresa Vilariño-García, Patricia Fernández-Riejos, Jenifer Martín-González, Juan José Segura-Egea, Víctor Sánchez-Margalet
Leptin is an adipocyte-derived hormone not only with an important role in the central control of energy metabolism, but also with many pleiotropic effects in different physiological systems. One of these peripheral functions of leptin is a regulatory role in the interplay between energy metabolism and the immune system, being a cornerstone of the new field of immunometabolism. Leptin receptor is expressed throughout the immune system and the regulatory effects of leptin include cells from both the innate and adaptive immune system...
March 4, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28235645/modification-of-the-fatty-acid-composition-of-an-obesogenic-diet-improves-the-maternal-and-placental-metabolic-environment-in-obese-pregnant-mice
#12
Martina Gimpfl, Jan Rozman, Maik Dahlhoff, Raphaela Kübeck, Andreas Blutke, Birgit Rathkolb, Martin Klingenspor, Martin Hrabě de Angelis, Soner Öner-Sieben, Annette Seibt, Adelbert A Roscher, Eckhard Wolf, Regina Ensenauer
Peri-conceptional exposure to maternal obesogenic nutrition is associated with in utero programming of later-life overweight and metabolic disease in the offspring. We aimed to investigate whether dietary intervention with a modified fatty acid quality in an obesogenic high-calorie (HC) diet during the preconception and gestational phases can improve unfavourable effects of an adipogenic maternal environment. In NMRI mice, peri-conceptional and gestational obesity was induced by feeding a HC diet (controls), and they were compared with dams on a fat-modified (Fat-mod) HC diet of the same energy content but enriched with medium-chain fatty acids (MCFAs) and adjusted to a decreased ratio of n-6 to n-3 long-chain polyunsaturated fatty acids (LC-PUFAs)...
February 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28193219/the-effect-of-an-antenatal-lifestyle-intervention-in-overweight-and-obese-women-on-circulating-cardiometabolic-and-inflammatory-biomarkers-secondary-analyses-from-the-limit-randomised-trial
#13
Lisa J Moran, Louise M Fraser, Tulika Sundernathan, Andrea R Deussen, Jennie Louise, Lisa N Yelland, Rosalie M Grivell, Anne Macpherson, Matthew W Gillman, Jeffrey S Robinson, Julie A Owens, Jodie M Dodd
BACKGROUND: Maternal overweight and obesity during pregnancy is associated with insulin resistance, hyperglycaemia, hyperlipidaemia and a low-grade state of chronic inflammation. The aim of this pre-specified analysis of secondary outcome measures was to evaluate the effect of providing antenatal dietary and lifestyle advice on cardiometabolic and inflammatory biomarkers. METHODS: We conducted a multicentre trial in which pregnant women who were overweight or obese were randomised to receive either Lifestyle Advice or Standard Care...
February 14, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28186371/gene-expression-and-epigenetic-aberrations-in-f1-placentas-fathered-by-obese-males
#14
Megan Mitchell, Reiner Strick, Pamela L Strissel, Ralf Dittrich, Nicole O McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Gene expression and/or epigenetic deregulation may have consequences for sperm and blastocysts, as well as for the placenta, together potentially contributing to problems observed in offspring. We previously demonstrated specific perturbations of fertilization, blastocyst formation, implantation, as well as aberrant glucose metabolism and adiposity in offspring using a mouse model of paternal obesity. The current investigation analyzed gene expression and methylation of specific CpG residues in F1 placentas of pregnancies fathered by obese and normal-weight male mice, using real-time PCR and bisulfite pyrosequencing...
February 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28177716/a-role-for-maternally-derived-myokines-to-optimize-placental-function-and-fetal-growth-across-gestation
#15
Chantal Dubé, Céline Aguer, Kristi Adamo, Shannon Bainbridge
Exercise during pregnancy is associated with improved health outcomes for both mother and baby, including a reduced risk of future obesity and susceptibility to chronic diseases. Overwhelming evidence demonstrates a protective effect of maternal exercise against fetal birth weight extremes, reducing the rates of both large- and small-for-gestational-age infants. It is speculated that this protective effect is mediated in part through exercise-induced regulation of maternal physiology and placental development and function...
May 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28168960/sex-specific-neurodevelopmental-programming-by-placental-insulin-receptors-on-stress-reactivity-and-sensorimotor-gating
#16
Stefanie L Bronson, Jennifer C Chan, Tracy L Bale
BACKGROUND: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk...
December 30, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28161063/influence-of-maternal-bmi-on-the-exosomal-profile-during-gestation-and-their-role-on-maternal-systemic-inflammation
#17
Omar Elfeky, Sherri Longo, Andrew Lai, Gregory E Rice, Carlos Salomon
Recent studies report that 35% of women are either overweight or obese at reproductive age. The placenta continuously releases exosomes across gestation and their concentration is higher in pregnancy complications. While there is considerable interest in elucidating the role of exosomes during gestation, important questions remain to be answered: i) Does maternal BMI affect the exosomal profile across gestation? and ii) What is the contribution of placenta-derived exosomes to the total number of exosomes present in maternal plasma across gestation? Plasma samples were classified according to the maternal BMI into three groups (n = 15 per group): Lean, overweight, and obese...
February 2017: Placenta
https://www.readbyqxmd.com/read/28125591/maternal-pre-pregnancy-obesity-is-associated-with-altered-placental-transcriptome
#18
Signe Altmäe, Maria Teresa Segura, Francisco J Esteban, Sabine Bartel, Pilar Brandi, Martin Irmler, Johannes Beckers, Hans Demmelmair, Carmen López-Sabater, Berthold Koletzko, Susanne Krauss-Etschmann, Cristina Campoy
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5) and normal weight women (n = 5), using the Affymetrix microarray platform. Analyses of expression data were carried out using non-parametric methods...
2017: PloS One
https://www.readbyqxmd.com/read/28111084/prepregnancy-maternal-diabetes-combined-with-obesity-impairs-placental-mitochondrial-function-involving-nrf2-are-pathway-and-detrimentally-alters-metabolism-of-offspring
#19
Yang Duan, Fuqiang Sun, Shengshun Que, Yueqin Li, Suyan Yang, Geli Liu
Metabolic disorders usually increase the level of reactive oxygen species (ROS) and damage mitochondrial function. The placenta supplies nutrients and hormonal signals to the fetus for regulating fetal metabolism, and is also prone to injury by oxidants. The aim of this study was to determine the effect of pre-existing maternal type 2 diabetes mellitus (DM) combined with obesity on placental mitochondrial function and metabolism disorders of offspring. The study included 96 pregnant women. The women were put into the following groups: healthy women (control, n=24), women with DM (DM, n=24), women with obesity (OB, n=24) and women with both DM and obesity (DM+OB, n=24)...
January 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28110332/role-of-insulin-in-placental-transport-of-nutrients-in-gestational-diabetes-mellitus
#20
María Ruiz-Palacios, Antonio José Ruiz-Alcaraz, María Sanchez-Campillo, Elvira Larqué
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects of diet or insulin treatment on the placental pathophysiology of GDM are unknown. SUMMARY: There are very few studies on possible defects in the insulin signaling pathway in the GDM placenta...
2017: Annals of Nutrition & Metabolism
keyword
keyword
109265
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"