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https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#1
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28886079/associations-between-lower-limb-muscle-activation-and-knee-flexion-in-post-stroke-individuals-a-study-on-the-stance-to-swing-phases-of-gait
#2
Wei Wang, Ke Li, Shouwei Yue, Cuiping Yin, Na Wei
Reduced knee flexion is a leading feature of post-stroke gait, but the causes have not been well understood. The purpose of this study was to investigate the relationship between the knee flexion and the lower-limb muscle activation within the stance-to-swing phases of gait cycle in the post-stroke hemiplegic patients. Ten stroke patients and 10 age- and gender-matched healthy subjects participated in the experiment. The lower-limb kinematic signals and the surface electromyography (sEMG) signals of the left and right rectus femoris (RF), biceps femoris (BF) and lateral gastrocnemius (GS) were recorded during walking...
2017: PloS One
https://www.readbyqxmd.com/read/28873030/differences-in-hamstring-activation-characteristics-between-the-acceleration-and-maximum-speed-phases-of-sprinting
#3
Ayako Higashihara, Yasuharu Nagano, Takashi Ono, Toru Fukubayashi
This study aimed to investigate activation characteristics of the biceps femoris long head (BFlh) and semitendinosus (ST) muscles during the acceleration and maximum-speed phases of sprinting. Lower-extremity kinematics and electromyographic (EMG) activities of the BFlh and ST muscles were examined during the acceleration sprint and maximum-speed sprint in 13 male sprinters during an overground sprinting. Differences in hamstring activation during each divided phases and in the hip and knee joint angles and torques at each time point of the sprinting gait cycle were determined between two sprints...
September 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28869185/gait-variability-and-motor-control-in-patients-with-knee-osteoarthritis-as-measured-by-the-uncontrolled-manifold-technique
#4
Gwenllian Fflur Tawy, Philip Rowe, Leela Biant
Knee osteoarthritis (OA) causes pain, reduced muscular strength and stiffness of the affected joint. In response, the motor control mechanism is altered, potentially compromising stability during acts of daily living. Reduced walking stability can be quantified in terms of gait variability. This study therefore aimed to identify and quantify the effects of knee arthritis on gait variability. Fifty adults (25 males/25 females) with end-stage OA of the knee sufficiently symptomatic to require joint replacement, walked on a self-paced treadmill for 2min...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28813993/the-influence-of-a-user-adaptive-prosthetic-knee-on-planned-gait-termination
#5
Erik C Prinsen, Marc J Nederhand, Bart F Koopman, Johan S Rietman
The added value of user-adaptive prosthetic knees has been predominantly evaluated in level walking or ramp/stair negotiation. Previous studies indicate that the activity pattern of individuals with an amputation mainly consists of short periods of continuous walking, indicating that a high percentage of ambulatory activity involves gait termination. The potential added value of user-adaptive prosthetic knees in gait termination has not been studied yet. Ten individuals with an amputation were measured with their own non-microprocessor controlled prosthetic knee and with the Rheo Knee II (a user-adaptive prosthetic knee)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28803956/selective-cholinergic-depletion-of-pedunculopontine-tegmental-nucleus-aggravates-freezing-of-gait-in-parkinsonian-rats
#6
Hu Xiao, Min Li, Junbin Cai, Nanxiang Li, Ming Zhou, Peng Wen, Zhengyuan Xie, Qiang Wang, Jingyu Chang, Wangming Zhang
Many patients of advanced Parkinson's disease (PD) suffer from intractable axial symptoms (severe gait and postural impairments), which were recently speculated to be more relevant to cholinergic degeneration in the brainstem than dopaminergic degeneration in the substantia nigra compacta (SNc). To investigate the role of the cholinergic cells of the pedunculopontine tegmental nucleus (PPTg) on motor deficits, especially the axial motor impairments, we measured and analyzed the gait performance of sham lesion rats, SNc dopaminergic lesion rats, PPTg cholinergic lesion rats, and combined lesion rats by using the CatWalk system...
August 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28754312/exercise-in-an-animal-model-of-parkinson-s-disease-motor-recovery-but-not-restoration-of-the-nigrostriatal-pathway
#7
M J Churchill, L Pflibsen, M D Sconce, C Moore, K Kim, C K Meshul
Many clinical studies have reported on the benefits of exercise therapy in patients with Parkinson's disease (PD). Exercise cannot stop the progression of PD or facilitate the recovery of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) (Bega et al., 2014). To tease apart this paradox, we utilized a progressive MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) mouse model in which we initiated 4weeks of treadmill exercise after the completion of toxin administration (i.e., restoration)...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28752319/lower-limb-muscle-activity-during-gait-in-individuals-with-hearing-loss
#8
Mahdi Majlesi, Elaheh Azadian, Nader Farahpour, Amir Ali Jafarnezhad, Hosein Rashedi
The objective of this study was to investigate the electrical activity of lower limb muscles during gait in an able-bodied control group and in deaf individuals. Thirty male children were equally divided into a control group and a group of deaf children. A portable EMG system was used to record the activity of the bilateral tibialis anterior, gastrocnemius medialis and vastus lateralis muscles during barefoot walking with and without dual task. For EMG analysis, the average root mean square (RMS) values of the five trials were calculated and then normalized based on the peak RMS obtained by the maximum isometric voluntary contraction...
July 27, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28735780/electromyographic-activity-of-the-vastus-intermedius-muscle-in-patients-with-stiff-knee-gait-after-stroke-a-retrospective-observational-study
#9
Davide Mazzoli, Erika Giannotti, Mario Manca, Maria Longhi, Paolo Prati, Michela Cosma, Giovanni Ferraresi, Monica Morelli, Paolo Zerbinati, Stefano Masiero, Andrea Merlo
Stiff-knee gait (SKG) in hemiplegic patients is often due to an inappropriate activity of the quadriceps femoris. However, there are no studies in literature addressing the vastus intermedius (VI) involvement in SKG. In this study, VI activity was analyzed in a sample of 46 chronic stroke patients with SKG, during spontaneous gait. VI activity was recorded by fine-wire electrodes inserted under ultrasound guidance then confirmed by electrical stimulation. The measured VI activity was compared to the normal reference pattern reported in literature and classified (e...
July 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28725270/inter-segmental-motions-of-the-foot-differences-between-younger-and-older-healthy-adult-females
#10
Dong Yeon Lee, Sang Gyo Seo, Eo Jin Kim, Doo Jae Lee, Kee Jeong Bae, Kyoung Min Lee, In Ho Choi
BACKGROUND: Although accumulative evidence exists that support the applicability of multi-segmental foot models (MFMs) in evaluating foot motion in various pathologic conditions, little is known of the effect of aging on inter-segmental foot motion. The objective of this study was to evaluate differences in inter-segmental motion of the foot between older and younger adult healthy females during gait using a MFM with 15-marker set. METHODS: One hundred symptom-free females, who had no radiographic evidence of osteoarthritis, were evaluated using MFM with 15-marker set...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28710326/cortical-influences-drive-amyotrophic-lateral-sclerosis
#11
REVIEW
Andrew Eisen, Heiko Braak, Kelly Del Tredici, Roger Lemon, Albert C Ludolph, Matthew C Kiernan
The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related to vocalisation and breathing, and possibly diffuse fasciculation, characteristic of ALS...
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28576131/analysis-of-31-year-old-patient-with-syngap1-gene-defect-points-to-importance-of-variants-in-broader-splice-regions-and-reveals-developmental-trajectory-of-syngap1-associated-phenotype-case-report
#12
Darina Prchalova, Marketa Havlovicova, Katalin Sterbova, Viktor Stranecky, Miroslava Hancarova, Zdenek Sedlacek
BACKGROUND: Whole exome sequencing is a powerful tool for the analysis of genetically heterogeneous conditions. The prioritization of variants identified often focuses on nonsense, frameshift and canonical splice site mutations, and highly deleterious missense variants, although other defects can also play a role. The definition of the phenotype range and course of rare genetic conditions requires long-term clinical follow-up of patients. CASE PRESENTATION: We report an adult female patient with severe intellectual disability, severe speech delay, epilepsy, autistic features, aggressiveness, sleep problems, broad-based clumsy gait and constipation...
June 2, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28549648/characterization-of-long-term-gait-deficits-in-mouse-dmcao-using-the-catwalk-system
#13
E Caballero-Garrido, J C Pena-Philippides, Z Galochkina, E Erhardt, T Roitbak
Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance...
July 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28535762/gait-initiation-and-termination-strategies-in-patients-with-prader-willi-syndrome
#14
Veronica Cimolin, Nicola Cau, Manuela Galli, Cristina Santovito, Graziano Grugni, Paolo Capodaglio
BACKGROUND: Gait Initiation (GI) is a functional task representing one of the first voluntary destabilizing behaviours observed in the development of a locomotor pattern as the whole body centre of mass transitions from a large to a small base of support. Conversely, Gait Termination (GT) consists in the transition from walking to standing which, in everyday life, is a very common movement. Compared to normal walking, it requires higher control of postural stability. For a safe GT, the forward movement of the body has to be slowed down to achieve a stable upright position...
May 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28530503/comparison-of-self-selected-walking-speeds-and-walking-speed-variability-when-data-are-collected-during-repeated-discrete-trials-and-during-continuous-walking
#15
Marcus J Brown, Laura A Hutchinson, Michael J Rainbow, Kevin J Deluzio, Alan R De Asha
A typical gait analysis data collection consists of a series of discrete trials, where a participant initiates gait, walks through a motion capture volume, and then terminates gait. This is not a normal 'everyday' gait pattern, yet measurements are considered representative of normal walking. However, walking speed, a global descriptor of gait quality that can affect joint kinematics and kinetics, may be different during discrete trials, compared to continuous walking. Therefore, the purpose of this study was to investigate the effect of continuous walking versus discrete trials on walking speed and walking speed variability...
May 22, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28487630/analysis-of-interrelationships-among-voluntary-and-prosthetic-leg-joint-parameters-using-cyclograms
#16
Farahiyah Jasni, Nur Azah Hamzaid, Nor Elleeiana Mohd Syah, Tze Y Chung, Noor Azuan Abu Osman
The walking mechanism of a prosthetic leg user is a tightly coordinated movement of several joints and limb segments. The interaction among the voluntary and mechanical joints and segments requires particular biomechanical insight. This study aims to analyze the inter-relationship between amputees' voluntary and mechanical coupled leg joints variables using cyclograms. From this analysis, the critical gait parameters in each gait phase were determined and analyzed if they contribute to a better powered prosthetic knee control design...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28450686/serial-neurophysiological-and-neurophysiological-examinations-for-delayed-facial-nerve-palsy-in-a-patient-with-fisher-syndrome
#17
Motoyuki Umekawa, Keiko Hatano, Hideyuki Matsumoto, Takahiro Shimizu, Hideji Hashida
The patient was a 47-year-old man who presented with diplopia and gait instability with a gradual onset over the course of three days. Neurological examinations showed ophthalmoplegia, diminished tendon reflexes, and truncal ataxia. Tests for anti-GQ1b antibodies and several other antibodies to ganglioside complex were positive. We made a diagnosis of Fisher syndrome. After administration of intravenous immunoglobulin, the patient's symptoms gradually improved. However, bilateral facial palsy appeared during the recovery phase...
May 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28380319/the-coefficient-of-friction-in-parkinson-s-disease-gait
#18
Ana Kleiner, M Galli, M Franceschini, M F De Pandis, F Stocchi, G Albertini, Ricardo Machado Leite de Barros
This study aimed to characterize the coefficient of friction (COF) curves of patients with Parkinson's disease (PD) during barefoot gait and to evaluate the relationships between this variable and functional scales. Twenty-two subjects with PD (ON phase of levodopa) and 22 healthy subjects participated in this study. The participants walked barefoot along a pathway that went over two force plates embedded in the floor of the data collection room. The instantaneous COF was calculated as the ratio between the horizontal and vertical components of the ground reaction forces...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28324993/dynamic-knee-muscle-co-contraction-quantified-during-walking
#19
Annachiara Strazza, Alessandro Mengarelli, Valentina Agostini, Marco Knaflitz, Laura Burattini, Sandro Fioretti, Francesco Di Nardo
The purpose of the present study was the quantification of the co-activation patterns of the knee extensor and flexor muscles during walking at self-selected speed and cadence. To this aim, the Statistical Gait Analysis, a recent methodology providing a statistical characterization of gait, was performed on surface EMG signals from Vastus Lateralis (VL) and Medial Hamstrings (MH) in 14 healthy young adult subjects. Muscular co-contraction was assessed as the overlapping period between activation intervals of agonist and antagonist muscles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28306641/a-kinematic-symmetry-index-of-gait-pattern-between-older-adults-with-and-without-low-back-pain
#20
Paul S Sung, Pamela Danial
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To investigate the symmetry index for limb support patterns in right limb dominant older adults with and without low back pain (LBP). SUMMARY OF BACKGROUND DATA: The effects of bilateral asymmetry on gait performance were reported; however, there is a lack of understanding on kinematic symmetry to assess subjects with LBP. This asymmetry might be related to increased compensatory patterns to the dominant side in subjects with LBP...
March 16, 2017: Spine
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