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https://www.readbyqxmd.com/read/29148155/identifying-biomechanical-gait-parameters-in-adolescent-boys-with-haemophilia-using-principal-component-analysis
#1
L B Suckling, D Stephensen, M C Cramp, R Mahaffey, W I Drechsler
INTRODUCTION: Improvements in the medical management for those with haemophilia have resulted in improved clinical outcomes. However, current treatment regimens do not alleviate all joint haemarthroses with the potential for long-term joint deterioration remaining. The evaluation of functional activities such as gait, using standardized tools to monitor children with haemophilia is emerging. AIM: This study explored differences in sagittal plane biomechanics of walking in adolescent boys aged 11-18 years with haemophilia and an age-matched group of typically developing boys...
November 17, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29121964/muscle-force-distribution-of-the-lower-limbs-during-walking-in-diabetic-individuals-with-and-without-polyneuropathy
#2
Aline A Gomes, Marko Ackermann, Jean P Ferreira, Maria Isabel V Orselli, Isabel C N Sacco
BACKGROUND: Muscle force estimation could advance the comprehension of the neuromuscular strategies that diabetic patients adopt to preserve walking ability, which guarantees their independence as they deal with their neural and muscular impairments due to diabetes and neuropathy. In this study, the lower limb's muscle force distribution during gait was estimated and compared in diabetic patients with and without polyneuropathy. METHODS: Thirty individuals were evaluated in a cross-sectional study, equally divided among controls (CG) and diabetic patients with (DNG) and without (DG) polyneuropathy...
November 9, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29109113/generation-and-characterization-of-sult4a1-mutant-mouse-models
#3
Patrick L Garcia, Mohammed I Hossain, Shaida A Andrabi, Charles N Falany
Sulfotransferase 4A1 (SULT4A1) belongs to the cytosolic sulfotransferase (SULT) superfamily of enzymes that catalyze sulfonation reactions with a variety of endogenous and exogenous substrates. Of the SULTs, SULT4A1 was shown to have the highest sequence homology between vertebrate species, yet no known function or enzymatic activity have been identified for this orphan SULT. To better understand SULT4A1 function in mammalian brain, two mutant SULT4A1 mouse strains were generated utilizing CRISPR-Cas9 technology...
November 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29103600/upper-body-accelerations-during-planned-gait-termination-in-young-and-older-women
#4
Lorenzo Rum, Luca Laudani, Andrea Macaluso, Giuseppe Vannozzi
Transitory tasks, such as gait termination, involve interactions between neural and biomechanical factors that challenge postural stability and head stabilization patterns in older adults. The aim of the study was to compare upper body patterns of acceleration during planned gait termination at different speeds between young and older women. Ten young and 10 older women were asked to carry out three gait termination trials at slow, comfortable and fast speed. A stereophotogrammetric system and a 15-body segments model were used to calculate antero-posterior whole-body Center of Mass (AP CoM) speed and to reconstruct the centroids of head, trunk and pelvis segments...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29080098/gait-bradykinesia-in-parkinson-s-disease-a-change-in-the-motor-program-which-controls-the-synergy-of-gait
#5
Tateo Warabi, Hiroyasu Furuyama, Eri Sugai, Masamichi Kato, Nobuo Yanagisawa
This study examined how gait bradykinesia is changed by the motor programming in Parkinson's disease. Thirty-five idiopathic Parkinson's disease patients and nine age-matched healthy subjects participated in this study. After the patients fixated on a visual-fixation target (conditioning-stimulus), the voluntary-gait was triggered by a visual on-stimulus. While the subject walked on a level floor, soleus, tibialis anterior EMG latencies, and the y-axis-vector of the sole-floor reaction force were examined. Three paradigms were used to distinguish between the off-/on-latencies...
October 27, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29075175/three-dimensional-trunk-and-lower-limbs-characteristics-during-gait-in-patients-with-huntington-s-disease
#6
Elzbieta Mirek, Magdalena Filip, Wiesław Chwała, Krzysztof Banaszkiewicz, Monika Rudzinska-Bar, Jadwiga Szymura, Szymon Pasiut, Andrzej Szczudlik
Objective: A number of studies on gait disturbances have been conducted, however, no clear pattern of gait disorders was described. The aim of the study was to characterize the gait pattern in HD patients by conducting analysis of mean angular movement changes the lower limb joints and trunk (kinematics parameters). Methods: The study group consisted of 30 patients with HD (17 women and 13 men). The reference data include the results of 30 healthy subjects (17 women and 13 men). Registration of gait with the Vicon 250 system was performed using passive markers attached to specific anthropometric points directly on the skin, based on the Golem biomechanical model (Oxford Metrics Ltd...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29060644/antagonist-thigh-muscle-activity-in-6-to-8-year-old-children-assessed-by-surface-emg-during-walking
#7
Francesco Di Nardo, Annachiara Strazza, Alessandro Mengarelli, Serena Ercolani, Laura Burattini, Sandro Fioretti
Analysis of muscle co-contractions seems to be relevant in the characterization of children pathologies such as spastic cerebral palsy. The aim of the study was the quantification of thigh-muscle co-contractions during walking in healthy children. To this aim, the Statistical Gait Analysis, a recent methodology providing a statistical characterization of gait, was performed on surface EMG signals from Vastus Medialis (VM) and Lateral Hamstrings (LH) in 30 healthy 6-to-8-year-old children. Muscular co-contraction was assessed as the overlapping period between activation intervals of agonist and antagonist muscles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28985487/lower-extremity-dynamics-of-walking-in-neuropathic-diabetic-patients-who-wear-a-forefoot-offloading-shoe
#8
Sicco A Bus, Josina C Maas, Nicoline M Otterman
BACKGROUND: A forefoot-offloading shoes has a negative-heel rocker outsole and is used to treat diabetic plantar forefoot ulcers, but its mechanisms of action and their association with offloading and gait stability are not sufficiently clear. METHODS: Ten neuropathic diabetic patients were tested in a forefoot-offloading shoe and subsequently in a control shoe with no specific offloading construction, both worn on the right foot (control shoe on left), while walking at 1...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28981420/knee-motion-generation-method-for-transfemoral-prosthesis-based-on-kinematic-synergy-and-inertial-motion
#9
Hiroshi Sano, Takahiro Wada
Previous research has shown that the effective use of inertial motion (i.e., less or no torque input at the knee joint) plays an important role in achieving a smooth gait of transfemoral prostheses in the swing phase. In our previous research, a method for generating a timed knee trajectory close to able-bodied individuals, which leads to sufficient clearance between the foot and the floor and the knee extension, was proposed using the inertial motion. Limb motions are known to correlate with each other during walking...
October 5, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#10
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 14, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28886079/associations-between-lower-limb-muscle-activation-and-knee-flexion-in-post-stroke-individuals-a-study-on-the-stance-to-swing-phases-of-gait
#11
Wei Wang, Ke Li, Shouwei Yue, Cuiping Yin, Na Wei
Reduced knee flexion is a leading feature of post-stroke gait, but the causes have not been well understood. The purpose of this study was to investigate the relationship between the knee flexion and the lower-limb muscle activation within the stance-to-swing phases of gait cycle in the post-stroke hemiplegic patients. Ten stroke patients and 10 age- and gender-matched healthy subjects participated in the experiment. The lower-limb kinematic signals and the surface electromyography (sEMG) signals of the left and right rectus femoris (RF), biceps femoris (BF) and lateral gastrocnemius (GS) were recorded during walking...
2017: PloS One
https://www.readbyqxmd.com/read/28873030/differences-in-hamstring-activation-characteristics-between-the-acceleration-and-maximum-speed-phases-of-sprinting
#12
Ayako Higashihara, Yasuharu Nagano, Takashi Ono, Toru Fukubayashi
This study aimed to investigate activation characteristics of the biceps femoris long head (BFlh) and semitendinosus (ST) muscles during the acceleration and maximum-speed phases of sprinting. Lower-extremity kinematics and electromyographic (EMG) activities of the BFlh and ST muscles were examined during the acceleration sprint and maximum-speed sprint in 13 male sprinters during an overground sprinting. Differences in hamstring activation during each divided phases and in the hip and knee joint angles and torques at each time point of the sprinting gait cycle were determined between two sprints...
September 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28869185/gait-variability-and-motor-control-in-patients-with-knee-osteoarthritis-as-measured-by-the-uncontrolled-manifold-technique
#13
Gwenllian Fflur Tawy, Philip Rowe, Leela Biant
Knee osteoarthritis (OA) causes pain, reduced muscular strength and stiffness of the affected joint. In response, the motor control mechanism is altered, potentially compromising stability during acts of daily living. Reduced walking stability can be quantified in terms of gait variability. This study therefore aimed to identify and quantify the effects of knee arthritis on gait variability. Fifty adults (25 males/25 females) with end-stage OA of the knee sufficiently symptomatic to require joint replacement, walked on a self-paced treadmill for 2min...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28813993/the-influence-of-a-user-adaptive-prosthetic-knee-on-planned-gait-termination
#14
Erik C Prinsen, Marc J Nederhand, Bart F Koopman, Johan S Rietman
The added value of user-adaptive prosthetic knees has been predominantly evaluated in level walking or ramp/stair negotiation. Previous studies indicate that the activity pattern of individuals with an amputation mainly consists of short periods of continuous walking, indicating that a high percentage of ambulatory activity involves gait termination. The potential added value of user-adaptive prosthetic knees in gait termination has not been studied yet. Ten individuals with an amputation were measured with their own non-microprocessor controlled prosthetic knee and with the Rheo Knee II (a user-adaptive prosthetic knee)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28803956/selective-cholinergic-depletion-of-pedunculopontine-tegmental-nucleus-aggravates-freezing-of-gait-in-parkinsonian-rats
#15
Hu Xiao, Min Li, Junbin Cai, Nanxiang Li, Ming Zhou, Peng Wen, Zhengyuan Xie, Qiang Wang, Jingyu Chang, Wangming Zhang
Many patients of advanced Parkinson's disease (PD) suffer from intractable axial symptoms (severe gait and postural impairments), which were recently speculated to be more relevant to cholinergic degeneration in the brainstem than dopaminergic degeneration in the substantia nigra compacta (SNc). To investigate the role of the cholinergic cells of the pedunculopontine tegmental nucleus (PPTg) on motor deficits, especially the axial motor impairments, we measured and analyzed the gait performance of sham lesion rats, SNc dopaminergic lesion rats, PPTg cholinergic lesion rats, and combined lesion rats by using the CatWalk system...
October 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28754312/exercise-in-an-animal-model-of-parkinson-s-disease-motor-recovery-but-not-restoration-of-the-nigrostriatal-pathway
#16
M J Churchill, L Pflibsen, M D Sconce, C Moore, K Kim, C K Meshul
Many clinical studies have reported on the benefits of exercise therapy in patients with Parkinson's disease (PD). Exercise cannot stop the progression of PD or facilitate the recovery of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) (Bega et al., 2014). To tease apart this paradox, we utilized a progressive MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) mouse model in which we initiated 4weeks of treadmill exercise after the completion of toxin administration (i.e., restoration)...
September 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28752319/lower-limb-muscle-activity-during-gait-in-individuals-with-hearing-loss
#17
Mahdi Majlesi, Elaheh Azadian, Nader Farahpour, Amir Ali Jafarnezhad, Hosein Rashedi
The objective of this study was to investigate the electrical activity of lower limb muscles during gait in an able-bodied control group and in deaf individuals. Thirty male children were equally divided into a control group and a group of deaf children. A portable EMG system was used to record the activity of the bilateral tibialis anterior, gastrocnemius medialis and vastus lateralis muscles during barefoot walking with and without dual task. For EMG analysis, the average root mean square (RMS) values of the five trials were calculated and then normalized based on the peak RMS obtained by the maximum isometric voluntary contraction...
September 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28735780/electromyographic-activity-of-the-vastus-intermedius-muscle-in-patients-with-stiff-knee-gait-after-stroke-a-retrospective-observational-study
#18
Davide Mazzoli, Erika Giannotti, Mario Manca, Maria Longhi, Paolo Prati, Michela Cosma, Giovanni Ferraresi, Monica Morelli, Paolo Zerbinati, Stefano Masiero, Andrea Merlo
Stiff-knee gait (SKG) in hemiplegic patients is often due to an inappropriate activity of the quadriceps femoris. However, there are no studies in literature addressing the vastus intermedius (VI) involvement in SKG. In this study, VI activity was analyzed in a sample of 46 chronic stroke patients with SKG, during spontaneous gait. VI activity was recorded by fine-wire electrodes inserted under ultrasound guidance then confirmed by electrical stimulation. The measured VI activity was compared to the normal reference pattern reported in literature and classified (e...
July 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28725270/inter-segmental-motions-of-the-foot-differences-between-younger-and-older-healthy-adult-females
#19
Dong Yeon Lee, Sang Gyo Seo, Eo Jin Kim, Doo Jae Lee, Kee Jeong Bae, Kyoung Min Lee, In Ho Choi
BACKGROUND: Although accumulative evidence exists that support the applicability of multi-segmental foot models (MFMs) in evaluating foot motion in various pathologic conditions, little is known of the effect of aging on inter-segmental foot motion. The objective of this study was to evaluate differences in inter-segmental motion of the foot between older and younger adult healthy females during gait using a MFM with 15-marker set. METHODS: One hundred symptom-free females, who had no radiographic evidence of osteoarthritis, were evaluated using MFM with 15-marker set...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28710326/cortical-influences-drive-amyotrophic-lateral-sclerosis
#20
REVIEW
Andrew Eisen, Heiko Braak, Kelly Del Tredici, Roger Lemon, Albert C Ludolph, Matthew C Kiernan
The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related to vocalisation and breathing, and possibly diffuse fasciculation, characteristic of ALS...
November 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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