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https://www.readbyqxmd.com/read/30236102/associations-between-post-operative-rehabilitation-of-hip-fracture-and-outcomes-national-database-analysis
#1
Bowen Su, Roger Newson, Harry Soljak, Michael Soljak
BACKGROUND: Rehabilitation programmes are used to improve hip fracture outcomes. There is little published trial clinical trial or population-based data on the effects of the type or provider of rehabilitation treatments on hip fracture outcomes. We evaluated the associations of rehabilitation interventions with post-operative hip fracture outcomes. METHODS: Cross-sectional (2013-2015) analysis of data from the English National Hip Fracture Database (NHFD) from all 191 English hospitals treating hip fractures...
July 9, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30232769/autosomal-recessive-iron-deficiency-anemia-dystonia-and-hypermanganesemia-caused-by-new-variant-mutation-of-the-manganese-transporter-gene-slc39a14
#2
Adel Zeglam, Abdusalam Abugrara, Mariam Kabuka
This inborn error of manganese metabolism has only recently been identified. A total of 28 affected individuals from ten families are known worldwide. Mutations in SLC39A14, encoding a Mn uptake transporter, have recently been recognized to cause excessive Mn concentrations in the blood which is believed to be neurotoxic and lead to a parkinsonian-like movement disorder caused by accumulation of Mn in the basal ganglia. We are reporting a new variant of SLC39A14 gene mutation (OMIM 608736 8p21.3) that has never been described in the literature so far...
September 19, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/30223404/development-and-validation-of-a-modified-performance-oriented-mobility-assessment-tool-for-assessing-mobility-in-children-with-hypophosphatasia
#3
Dawn Phillips, Donna Griffin, Tracy Przybylski, Erica Morrison, Amy L Reeves, Marc Vallee, Kenji P Fujita, Katherine L Madson
PURPOSE: To modify the Performance-Oriented Mobility Assessment-Gait (POMA-G) subtest and validate this modified POMA-G (mPOMA-G) in children with hypophosphatasia (HPP), a rare metabolic disorder that can manifest with musculoskeletal symptoms that impair mobility and ambulation. METHODS: Based on feedback from an expert panel, the POMA-G was modified by removing gait initiation/path assessments and expanding the rating scale for step length/continuity to capture aspects of observational gait analysis relevant to children with HPP...
September 7, 2018: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/30216556/autopsy-case-of-v180i-genetic-creutzfeldt-jakob-disease-presenting-with-early-disease-pathology
#4
Yasushi Iwasaki, Hiroko Kato, Tetsuo Ando, Akio Akagi, Maya Mimuro, Hiroaki Miyahara, Tetsuyuki Kitamoto, Mari Yoshida
The patient was a Japanese woman who experienced a decrease in activity and gait disturbance as the initial symptoms at the age of 86, followed by disorientation and memory dysfunction. Magnetic resonance imaging showed extensive cortical regions with hyperintensity in diffusion-weighted images, and these regions showed swelling in T2-weighted and fluid-attenuated inversion recovery (FLAIR) images. The medial occipital cortex and striatum showed no apparent hyperintensity on diffusion-weighted imaging (DWI)...
September 14, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/30209583/variety-of-preoperative-mri-changes-in-spinal-cord-ependymoma-of-who-grade-ii-a-case-series
#5
Kazuyoshi Kobayashi, Kei Ando, Fumihiko Kato, Koji Sato, Mitsuhiro Kamiya, Mikito Tsushima, Masaaki Machino, Kyotaro Ota, Masayoshi Morozumi, Satoshi Tanaka, Shunsuke Kanbara, Sadayuki Ito, Naoki Ishiguro, Shiro Imagama
PURPOSE: To report a case series of surgically proven spinal ependymomas of WHO grade II in which there were changes in the preoperative MRI characteristics over time. METHODS: A total of 71 patients with spinal cord ependymoma of WHO grade II underwent surgery. There were ten cases in which surgery was performed at an average of 2.2 years after the tumor was found. Cystic components, syringomyelia, hemorrhage "cap sign," Gd enhancement pattern, characteristic changes in MRI, MIB-1 index, and neurological assessment during the preoperative period were examined...
September 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/30197627/central-precocious-puberty-in-a-child-with-metachromatic-leukodystrophy
#6
Gilda Belli, Emanuele Bartolini, Andrea Bianchi, Mario Mascalchi, Stefano Stagi
Metachromatic leucodystrophy (MLD) is a rare inherited lysosomal disorder caused by reduced activity of the enzyme arylsulfatase A with accumulation of sulfatides in the nervous system. We report a female child affected by MLD who developed central precocious puberty (CPP). This association has not been described so far. The proposita, after normal growth and psychomotor development, at age of 30 months presented with a rapidly progressive gait disturbance with frequent falls and with loss of acquired language skills...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30195221/how-do-children-with-bilateral-spastic-cerebral-palsy-manage-walking-on-inclines
#7
Miray-Su Yılmaz Topçuoğlu, Britta K Krautwurst, Matthias Klotz, Thomas Dreher, Sebastian I Wolf
BACKGROUND: Walking on inclined surfaces is an everyday task, which challenges stability and propulsion even in healthy adults. Children with cerebral palsy adapt similarly to inclines like healthy children do. However, how stability and propulsion in these subjects are influenced by different inclines remained unaddressed as of yet. RESEARCH QUESTION: The aim was to examine the feeling of safety, stability and propulsion of children with cerebral palsy when walking on inclines to gain insight into the challenges they might face on these conditions...
August 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30194247/retinal-vasculopathy-with-cerebral-leukoencephalopathy-rvcl-a-rare-mimic-of-tumefactive-ms
#8
Jenelle Raynowska, Dhanashri P Miskin, Bidyut Pramanik, Saeed Asiry, Todd Anderson, John Boockvar, Souhel Najjar, Asaff Harel
OBJECTIVE: We report a series of 2 brothers who each developed tumefactive brain lesions, initially thought to have brain tumors or tumefactive multiple sclerosis (MS), but who were ultimately diagnosed with a rare autosomal dominant condition known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL). METHODS: Case series and literature review. RESULTS: We present 2 brothers who developed tumefactive right frontal brain lesions leading to gait disturbances and cognitive changes...
September 7, 2018: Neurology
https://www.readbyqxmd.com/read/30193080/is-there-a-pathological-gait-associated-with-common-soft-tissue-running-injuries
#9
Christopher Bramah, Stephen J Preece, Niamh Gill, Lee Herrington
BACKGROUND: Previous research has demonstrated clear associations between specific running injuries and patterns of lower limb kinematics. However, there has been minimal research investigating whether the same kinematic patterns could underlie multiple different soft tissue running injuries. If they do, such kinematic patterns could be considered global contributors to running injuries. HYPOTHESIS: Injured runners will demonstrate differences in running kinematics when compared with injury-free controls...
September 7, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30189263/pedunculopontine-nucleus-an-integrative-view-with-implications-on-deep-brain-stimulation
#10
REVIEW
Andreas Nowacki, Salvatore Galati, Janine Ai-Schlaeppi, Claudio Bassetti, Alain Kaelin, Claudio Pollo
The pedunculopontine nucleus (PPN) is a reticular nucleus located in the mesencephalic and upper pontine tegmentum. Initially, characterized by its predominant cholinergic projection neurons, it was associated with the "mesencephalic locomotor region" and "reticular activating system". Furthermore, based on histopathological studies, the PPN was hypothesized to play a role in the manifestation of symptoms in movement disorders such as Parkinson's disease (PD). Since axial symptoms represent unmet needs of PD treatments, a series of pioneering experiments in Parkinsonian monkeys promoted the idea of a potential new target for deep brain stimulation (DBS) and much clinical interest was generated in the following years leading to a number of trials analysing the role of PPN for gait disorders...
September 3, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30175511/evaluation-of-neurobehavioral-impairment-in-methylmercury-treated-kk-ay-mice-by-dynamic-weight-bearing-test
#11
Megumi Yamamoto, Eriko Motomura, Rie Yanagisawa, Van Anh Thi Hoang, Masaki Mogi, Tomohisa Mori, Masaaki Nakamura, Motohiro Takeya, Komyo Eto
Methylmercury (MeHg) is known to cause neurobehavioral impairment in human and experimental animals. We previously reported that MeHg (5 mg Hg/kg) induced severe neurobehavioral dysfunction in 4-week-old KK-Ay mice, although it is difficult to evaluate quantitatively the neurobehavioral impairment in MeHg-treated KK-Ay mice because of their obesity. The aim of this study was to evaluate MeHg-induced neurobehavioral dysfunction in KK-Ay mice using the dynamic weight-bearing test, which analyzes the animal's weight distribution between the four limbs...
September 2, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/30171655/predicting-responsiveness-to-fampridine-in-gait-impaired-patients-with-multiple-sclerosis
#12
Linard Filli, Jana Werner, Gerrit Beyer, Katja Reuter, Jens A Petersen, Michael Weller, Björn Zörner, Michael Linnebank
BACKGROUND: Fampridine leads to significant walking improvements in many persons with multiple sclerosis (PwMS). However, a relevant proportion of PwMS does not respond to fampridine and predictors of initial drug responsiveness are unknown. METHODS: Drug response to prolonged-release (PR)-fampridine was assessed in 55 PwMS using the timed 25-foot walk (T25FW), the 6-minute walk test (6MWT) and the 12-item multiple sclerosis walking scale (MSWS-12) as outcome parameters...
September 1, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30170139/the-functional-spatio-temporal-and-satisfaction-outcomes-of-transtibial-amputees-with-a-hydrocast-socket-following-an-extended-usage-period-in-an-under-resourced-environment
#13
Sheridan Laing, Peter V S Lee, Jim Lavranos, Noel Lythgo
BACKGROUND: Transtibial hydrocast sockets have been shown to be a potential alternative to hand-cast patella-tendon bearing sockets, the use of which would have particular benefits in under-resourced environments. However, data concerning wearer outcomes of hard hydrocast sockets (i.e. those without silicone liners), especially over long-term usage periods, is scarce in the literature. RESEARCH QUESTIONS: Are there any changes in wearer functional, spatio-temporal or satisfaction outcomes over a long usage period with a hydrocast socket? And how do the post-usage period outcomes compare with those from the wearers original prostheses? METHODS: In this pre-post interventional study, the clinical outcomes of twenty-one experienced transtibial prostheses users were evaluated using widely-accepted and employed methods to assess wearer functional capacity, mobility, gait and satisfaction...
August 22, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30168357/does-an-inverted-pendulum-model-represent-the-gait-of-individuals-with-unilateral-transfemoral-amputation-while-walking-over-level-ground
#14
Gerda Strutzenberger, Nathalie Alexander, Alan De Asha, Hermann Schwameder, Cleveland Thomas Barnett
BACKGROUND: An inverted pendulum model represents the mechanical function of able-bodied individuals walking accurately, with centre of mass height and forward velocity data plotting as sinusoidal curves, 180° out of phase. OBJECTIVES: This study investigated whether the inverted pendulum model represented level gait in individuals with a unilateral transfemoral amputation. STUDY DESIGN: Controlled trial. METHODS: Kinematic and kinetic data from 10 individuals with unilateral transfemoral amputation and 15 able-bodied participants were recorded during level walking...
August 31, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/30161216/gait-comparison-of-unicompartmental-knee-arthroplasty-and-total-knee-arthroplasty-during-level-walking
#15
Kyung-Wook Nha, Oog-Jin Shon, Byung-Sic Kong, Young-Soo Shin
This meta-analysis compared the gait patterns of unicompartmental knee arthroplasty (UKA) patients and total knee arthroplasty (TKA) patients during level walking by evaluating the kinetics, kinematics, and spatiotemporal parameters. Studies were included in the meta-analysis if they assessed the vertical ground reaction force (GRF), joint moment at stance, flexion at initial contact, flexion at swing, overall range of motion (ROM), coronal knee angle at stance, walking speed, cadence, and stride length in UKA patients or TKA patients...
2018: PloS One
https://www.readbyqxmd.com/read/30160572/physical-activity-and-future-physical-function-data-from-the-osteoarthritis-initiative
#16
Chris Hopkins
Declining physical function is common among aging adults, however physical activity may decrease the rate of functional loss among adults with or at risk of developing osteoarthritis. Previous studies on this topic used subjective measures of physical activity and were subject to higher selection bias. This study employed propensity score matching techniques to reduce selection bias when measuring the association between objectively-measured physical activity and future physical function. 687 participants of the Osteoarthritis Initiative were included in either a physically active group (n=280) or a physically inactive group (n=407) according to baseline accelerometer data...
August 30, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/30156089/use-of-3d-gait-analysis-as-predictor-of-achilles-tendon-lengthening-surgery-outcomes-in-children-with-cerebral-palsy
#17
Giuseppina Pilloni, Massimiliano Pau, Francesco Costici, Claudia Condoluci, Manuela Galli
BACKGROUND: In children with spastic Cerebral Palsy (CP), the treatment of equinus foot with Achilles tendon lengthening (ATL) surgery is associated with high incidence of overcorrection, which may result in crouch gait. AIM: We aimed to assess if gait pattern in preoperative time could be a predictor of the surgery outcome. DESIGN: Cross-sectional retrospective study. SETTING: Movement Analysis Lab, IRCCS San Raffaele Pisana Hospital, Rome (ITALY)...
August 27, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/30155740/startreact-during-gait-initiation-reveals-differential-control-of-muscle-activation-and-inhibition-in-patients-with-corticospinal-degeneration
#18
Bas J H van Lith, Milou J M Coppens, Jorik Nonnekes, Bart P C van de Warrenburg, Alexander C Geurts, Vivian Weerdesteyn
Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of reaction times by a startling acoustic stimulus (SAS) simultaneously presented with the imperative stimulus. As previous StartReact studies mainly focused on isolated single-joint movements, the question remains whether the reticulospinal tract can also be utilized for controlling whole-body movements...
August 28, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30149783/a-case-of-mercury-toxicity-complicated-by-acute-inflammatory-demyelinating-polyneuropathy
#19
Stacey Evans, Jeffrey Smith, Elena Caron
A 13-year-old African American male presented with 2 months of subacute altered mental status, ptosis, areflexia, disordered gait, constipation, weight loss, abdominal and testicular pain, and hyperhidrosis. Initial workup at our facility was unrevealing until elevated serum mercury level was detected. Diagnosis of mercury toxicity was confirmed, and chelation therapy with succimer was started. After beginning succimer, the patient developed acute-onset weakness and was diagnosed with acute inflammatory demyelinating polyneuropathy...
August 28, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/30148245/effects-of-an-articulated-ankle-foot-orthosis-on-gait-biomechanics-in-adolescents-with-traumatic-brain-injury-a-case-series-report
#20
B M Rogozinski, S E Schwab, T M Kesar
Purpose: To quantify the effects of an articulated ankle foot orthosis on genu recurvatum gait in adolescents with traumatic brain injury (TBI). Methods: Gait analysis was conducted in 2 individuals with TBI during over ground ambulation with (braced condition) and without (barefoot condition) the AAFO. For each participant, stride-by-stride gait data were compared to assess differences between barefoot and braced walking conditions. Results: During the braced versus barefoot condition, both participants demonstrated reduced plantar flexion at initial contact, increased knee flexion at initial contact, reduced peak knee extension during stance, and reduced peak and integral of internal knee flexor moment during stance...
2018: Physical Medicine and Rehabilitation International
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