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https://www.readbyqxmd.com/read/27863673/laser-irradiation-to-produce-amorphous-pharmaceuticals
#1
Varin Titapiwatanakun, Junlathip Tankul, Abdul W Basit, Simon Gaisford
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27832954/efficient-approach-to-enhance-drug-solubility-by-particle-engineering-of-bovine-serum-albumin
#2
Mouhamad Khoder, Hamdy Abdelkader, Amr ElShaer, Ayman Karam, Mohammad Najlah, Raid G Alany
The aim of this study was to investigate the use of bovine serum albumin (BSA) as a solubility enhancer for indometacin (IND) as a model drug. IND-BSA solid dispersions were prepared by both spray drying and freeze drying techniques using IND:BSA solution (20:1 Molar Ratio (MR)) and IND:BSA suspension (100:1 MR). The solid state of IND in solid dispersions was characterised by SEM, DSC and XRD. The aqueous solubility of IND in the presence of increased amounts of BSA was evaluated. Additionally, IND dissolution and release profiles were evaluated...
November 7, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27602398/in-vitro-cytotoxic-effects-of-celecoxib-mefenamic-acid-aspirin-and-indometacin-on-several-cells-lines
#3
Maryam Alsadat Hashemipour, Hoda Mehrabizadeh Honarmand, Farideh Falsafi, Mehrnaz Tahmasebi Arashlo, Saied Rajabalian, Sayed Amir Hossein Gandjalikhan Nassab
STATEMENT OF THE PROBLEM: Use of cyclooxygenase inhibitors as chemotherapy agents has attracted the attention of a large number of investigators in recent years. Given the importance of cancer therapy, only a limited number of studies have been carried out to investigate the effects of cyclooxygenase inhibitors on specific cell lines. PURPOSE: This research aimed to determine the in vitro cytotoxic effects of cyclooxygenase inhibitors (COX-1 and COX-2 inhibitors) on KB, Saos-2, 1321N, U-87MG, SFBF-PI 39 cell lines...
September 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27580214/endoscopic-and-pharmacological-treatment-for-prophylaxis-against-postendoscopic-retrograde-cholangiopancreatography-pancreatitis-a-meta-analysis-and-systematic-review
#4
Salvatore F Vadalà di Prampero, Giacomo Faleschini, Nikola Panic, Milutin Bulajic
BACKGROUND AND AIM: Postendoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis (PEP) is the most common complication following ERCP. We carried out a systematic review and meta-analysis of the global literature on PEP prevention to provide clinical guidance and a framework for future research in this important field. METHODS: PubMed, Embase, Science Citation Index, Ovid, and the Cochrane Controlled Trials Register were searched by two independent reviewers to identify full-length, prospective, randomized controlled trials (RCTs) published up until March 2016 investigating the use of pancreatic duct stents and pharmacological agents to prevent PEP...
August 31, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27511050/the-study-on-mechanism-of-the-modified-chinese-herbal-compound-jianpijiedu-on-a-mouse-model-of-hepatic-carcinoma-cachexia
#5
Baoguo Sun, Haoxuan Luo, Liuxiang Deng, Shijun Zhang, Zexiong Chen
Various studies have investigated hepatic carcinoma cachexia, however, there is little published information regarding the effect of Chinese Medicine carcinoma cachexia. The present study was performed to investigate the effect of modified Chinese herbal compound jianpijiedu (MJPJD) on a mouse model of ascites‑induced hepatic carcinoma cachexia. C57BL/6 mice were randomized to five groups: Control (Group A); xenograft tumor (Group B); low concentration of MJPJD (Group C); high concentration of MJPJD (Group D) and medroxyprogesterone (MPA) combined with indometacin (IND; Group E)...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27495133/trigeminal-autonomic-cephalgia-caused-by-recurrent-posterior-scleritis
#6
Ali Alim-Marvasti, Jason Ho, Mark Weatherall, Maneesh Patel, Sheena George, Stuart Viegas
A 40-year-old woman presented with a side-locked headache with autonomic features, which then switched sides before reverting to the original side. The atypical features of side swapping, partial response to indometacin and abnormal optic disc appearances ultimately led to a diagnosis of recurrent posterior scleritis. We discuss the differential diagnosis of trigeminal autonomic cephalgias and its secondary causes, and provide practical pointers for its investigation and management.
August 5, 2016: Practical Neurology
https://www.readbyqxmd.com/read/27466236/scissor-spinal-cord-injury-study-on-small-molecule-derived-rho-inhibition-a-clinical-study-protocol
#7
Marcel A Kopp, Thomas Liebscher, Ralf Watzlawick, Peter Martus, Stefan Laufer, Christian Blex, Ralf Schindler, Gerhard J Jungehulsing, Sven Knüppel, Martin Kreutzträger, Axel Ekkernkamp, Ulrich Dirnagl, Stephen M Strittmatter, Andreas Niedeggen, Jan M Schwab
INTRODUCTION: The approved analgesic and anti-inflammatory drugs ibuprofen and indometacin block the small GTPase RhoA, a key enzyme that impedes axonal sprouting after axonal damage. Inhibition of the Rho pathway in a central nervous system-effective manner requires higher dosages compared with orthodox cyclooxygenase-blocking effects. Preclinical studies on spinal cord injury (SCI) imply improved motor recovery after ibuprofen/indometacin-mediated Rho inhibition. This has been reassessed by a meta-analysis of the underlying experimental evidence, which indicates an overall effect size of 20...
July 26, 2016: BMJ Open
https://www.readbyqxmd.com/read/27444038/loxoprofen-a-review-in-pain-and-inflammation
#8
Sarah L Greig, Karly P Garnock-Jones
Loxoprofen (Loxonin(®), Loxonin(®) Pap, Loxonin(®) Tape) is a prodrug-type NSAID that is available in several formulations, including 60 mg tablets, 100 mg hydrogel patches and 50 or 100 mg tape. In active comparator-controlled trials, oral loxoprofen therapy (ranging from 2 days to 6 weeks' duration depending on the pain type) provided analgesic efficacy that generally did not significantly differ from that of celecoxib for postoperative pain or frozen shoulder, ibuprofen for knee osteoarthritis or naproxen for lumbar pain...
September 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27285464/prediction-of-fetal-ductus-arteriosus-constriction-by-systemic-and-local-dermatological-formulations-of-nsaids-based-on-pk-pd-analysis
#9
Shingo Tanaka, Satoko Hori, Hiroki Satoh, Yasufumi Sawada
AIM: Use of nonsteroidal antiinflammatory drugs (NSAIDs) during the final trimester of pregnancy can cause fetal toxicity, such as ductus arteriosus (DA) constriction. The aim of this study was to predict quantitatively the fetal DA-constrictive effects of NSAIDs after various routes of administration to the mother by means of harmacokinetic/pharmacodynamic (PK/PD) modeling. METHODS: We evaluated acetaminophen, which is a first-line analgesic/antipyretic for the third trimester of pregnancy, together with the following NSAIDs: indometacin, diclofenac, ibuprofen, flurbiprofen, ketoprofen, loxoprofen, felbinac, naproxen, and celecoxib...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27175607/diet-supplementation-with-rice-bran-enzymatic-extract-restores-endothelial-impairment-and-wall-remodelling-of-apoe-mice-microvessels
#10
Cristina Perez-Ternero, Rosalia Rodriguez-Rodriguez, Maria Dolores Herrera, Maria Alvarez de Sotomayor
BACKGROUND AND AIMS: Small mesenteric artery resistance and functionality are key factors for the maintenance of blood homeostasis. We attained to evaluate the effects of a rice bran enzymatic extract (RBEE) on structural, mechanic and myogenic alterations and endothelial dysfunction secondary to atherosclerosis disease. METHODS: Seven week-old ApoE(-/-) mice were fed on standard (ST) or high fat (HF) diets supplemented or not with 1 or 5% RBEE (w/w) for 23 weeks...
July 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27154251/transdermal-permeation-of-drugs-with-differing-lipophilicity-effect-of-penetration-enhancer-camphor
#11
Feng Xie, Jia-Ke Chai, Quan Hu, Yong-Hui Yu, Li Ma, Ling-Ying Liu, Xu-Long Zhang, Bai-Ling Li, Dong-Hai Zhang
The aim of the present study was to investigate the potential application of (+)-camphor as a penetration enhancer for the transdermal delivery of drugs with differing lipophilicity. The skin irritation of camphor was evaluated by in vitro cytotoxicity assays and in vivo transdermal water loss (TEWL) measurements. A series of model drugs with a wide span of lipophilicity (logP value ranging from 3.80 to -0.95), namely indometacin, lidocaine, aspirin, antipyrine, tegafur and 5-fluorouracil, were tested using in vitro transdermal permeation experiments to assess the penetration-enhancing profile of camphor...
June 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27133971/routine-pre-procedural-rectal-indometacin-versus-selective-post-procedural-rectal-indometacin-to-prevent-pancreatitis-in-patients-undergoing-endoscopic-retrograde-cholangiopancreatography-a-multicentre-single-blinded-randomised-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Hui Luo, Lina Zhao, Joseph Leung, Rongchun Zhang, Zhiguo Liu, Xiangping Wang, Biaoluo Wang, Zhanguo Nie, Ting Lei, Xun Li, Wence Zhou, Lingen Zhang, Qi Wang, Ming Li, Yi Zhou, Qian Liu, Hao Sun, Zheng Wang, Shuhui Liang, Xiaoyang Guo, Qin Tao, Kaichun Wu, Yanglin Pan, Xuegang Guo, Daiming Fan
BACKGROUND: Rectal indometacin decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, the population most at risk and the optimal timing of administration require further investigation. We aimed to assess whether pre-procedural administration of rectal indometacin in all patients is more effective than post-procedural use in only high-risk patients to prevent post-ERCP pancreatitis. METHODS: We did a multicentre, single-blinded, randomised controlled trial at six centres in China...
June 4, 2016: Lancet
https://www.readbyqxmd.com/read/27023565/non-steroidal-anti-inflammatory-drugs-and-aspirin-therapy-for-the-treatment-of-acute-and-recurrent-idiopathic-pericarditis
#13
REVIEW
Nicholas Schwier, Nicole Tran
Aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) are a mainstay of therapy for the treatment of idiopathic pericarditis (IP). A comprehensive review consisting of pertinent clinical literature, pharmacokinetic, and pharmacodynamic considerations, has not been released in recent years. This review will facilitate the clinician's understanding of pharmacotherapeutic considerations for using ASA/NSAIDs to treat IP. Data were compiled using clinical literature consisting of case reports, cohort data, retrospective and prospective studies, and manufacturer package inserts...
2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27022241/celastrol-inhibits-prostaglandin-e2-induced-proliferation-and-osteogenic-differentiation-of-fibroblasts-isolated-from-ankylosing-spondylitis-hip-tissues-in-vitro
#14
Yu-Cong Zou, Xian-Wen Yang, Shi-Guo Yuan, Pei Zhang, Yi-Kai Li
BACKGROUND: Heterotopic ossification on the enthesis, which develops after subsequent inflammation, is one of the most distinctive features in ankylosing spondylitis (AS). Prostaglandin E2 (PGE-2) serves as a key mediator of inflammation and bone remodeling in AS. Celastrol, a well-known Chinese medicinal herb isolated from Tripterygium wilfordii, is widely used in treating inflammatory diseases, including AS. It has been proven that it can inhibit lipopolysac-charide-induced expression of various inflammation mediators, such as PGE-2...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26901291/jujuboside-b-reduces-vascular-tension-by-increasing-ca2-influx-and-activating-endothelial-nitric-oxide-synthase
#15
Yixiu Zhao, Xin Zhang, Jiannan Li, Yu Bian, Miaomiao Sheng, Bin Liu, Zidong Fu, Yan Zhang, Baofeng Yang
Jujuboside B has been reported to have protective effect on many cardiovascular diseases. However, the effects of Jujuboside B on vascular tension and endothelial function are unknown. The present study investigated the effects of Jujuboside B on reducing vascular tension, protecting endothelial function and the potential mechanisms. The tension of isolated rat thoracic aorta ring was measured by Wire myograph system. The concentration of nitric oxide (NO) and the activity of endothelial nitric oxide synthase (eNOS) in human aortic endothelial cells (HAECs) were determined by Griess reagent method and enzyme-linked immune sorbent assay...
2016: PloS One
https://www.readbyqxmd.com/read/26776663/involvement-of-bradykinin-b2-and-muscarinic-receptors-in-the-prolonged-diuretic-and-antihypertensive-properties-of-echinodorus-grandiflorus-cham-schltdl-micheli
#16
Thiago Buno Lima Prando, Lorena Neris Barboza, Valdinei de Oliveira Araújo, Francielly Mourão Gasparotto, Lauro Mera de Souza, Emerson Luiz Botelho Lourenço, Arquimedes Gasparotto Junior
BACKGROUND: Although Echinodorus grandiflorus (Cham. & Schltr.) Michel are used in Brazilian folk medicine as a diuretic drug, to date, no study has evaluated the mechanisms involved in this activity after prolonged administration in rats. AIM OF THE STUDY: Evaluate the possible mechanisms involved in the prolonged diuretic activity of ethanol soluble fraction obtained from Echinodorus grandiflorus (ES-EG) and to assess its relationship with hypotensive and antihypertensive activity using normotensive rats and those with renovascular hypertension (2K1C)...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26660274/coordination-polymers-derived-from-non-steroidal-anti-inflammatory-drugs-for-cell-imaging-and-drug-delivery
#17
Mithun Paul, Parthasarathi Dastidar
A new series of Mn(II) coordination polymers, namely, [{Mn(L)(H2 O)2 }⋅2 Nap]∞ (CP1), [{Mn(L)(Ibu)2 (H2 O)2 }]∞ (CP2), [{Mn(L)(Flr)2 (H2 O)2 }]∞ (CP3), [{Mn(L)(Ind)2 (H2 O)2 }⋅H2 O]∞ (CP4), [{Mn2 (L)2 (μ-Flu)4 (H2 O)}⋅L]∞ (CP5), [{Mn2 (L)2 (μ-Tol)4 (H2 O)2 }]∞ (CP6) and [{Mn2 (L)2 (μ-Mef)4 (H2 O)2 }]∞ (CP7) (Nap=naproxen, Ibu=ibuprofen, Flr=flurbiprofen, Ind=indometacin, Flu=flufenamic acid, Tol=tolfenamic acid and Mef=mefenamic acid) derived from various non-steroidal anti-inflammatory drugs (NSAIDs) and the organic linker 1,2-bis(4-pyridyl)ethylene (L) have been synthesized with the aim of being used for cell imaging and drug delivery...
January 18, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26613737/colloidal-silica-induced-hypersensitivity-myth-or-reality
#18
Nadia Ben Fredj, Najeh Ben Fadhel, Amel Chaabane, Zohra Chadly, Haifa Ben Romdhane, Abderrazzek Boughattas, Karim Aouam
BACKGROUND: Many excipients have been reported to induce drug hypersensitivity (e.g. colouring additives, preservatives). Colloidal silica has never been reported to induce drug hypersensitivity reactions. CASE REPORT: We report herein a 40-year-old patient who developed a skin eruption 2 days after Voltarene(®) (diclofenac) intake, confirmed by a positive patch test. Investigation of cross reactivity, assessed by patch testing to other non steroidal anti-inflammatory drugs, have showed a positive reaction only to piroxicam (Piroxen(®)), ketoprofen (Oki(®)) and indometacin (Indocid(®))...
February 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/26480553/-clinical-research-of-chronic-pelvic-cavity-pain-syndrome-treated-with-acupoint-catgut-embedding-therapy
#19
RANDOMIZED CONTROLLED TRIAL
Yong Ma, Xinyuan Li, Fuqiang Li, Wenjun Yu, Zulong Wang
OBJECTIVE: To explore the clinical efficacy of acupoint catgut embedding therapy on chronic pelvic cavity pain syndrome differentiated as kidney deficiency and stagnation of damp heat, and explore the impacts on plasma P substance (SP), plasma beta-endorphin (β-EP). METHODS: One hundred and eighty cases were randomly divided into a catgut embedding group (90 cases) and a western medication group (90 cases). In the western medication group, tamsulosin capsules 0...
June 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/26476168/towards-high-potential-magnetic-biocatalysts-for-on-demand-elimination-of-pharmaceuticals
#20
Vaidyanathan Vinoth Kumar, Hubert Cabana
The present study investigated the applicability of a laccase based bioprocess for the treatment of a mixture containing 13 selected pharmaceuticals. To do so, laccase was immobilized as cross-linked enzyme aggregates (MAC-CLEAs) on amine functionalized magnetic nanoparticles using chitosan/1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC) as the cross-linking system. The activity recovery of laccase reached 61.4% under the optimal conditions of MAC-CLEAs formation. The latter exhibited enhanced storage stability over one year at 4°C and showed better temperature resistance compared to its soluble counterpart...
January 2016: Bioresource Technology
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