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https://www.readbyqxmd.com/read/29913768/chronic-non-cancer-pain-and-the-long-term-efficacy-and-safety-of-opioids-some-blind-men-and-an-elephant
#1
C Peter, N Watson
Background The use of opioids for chronic non-cancer pain (CNCP) remains very controversial. There are a number of randomized controlled trials (RCTs) showing efficacy and safety in the short-term, but long-term data are limited. Methods This article contains 10 case reports (followed to 2011) that were selected from a survey of 84 patients with intractable CNCP treated with opioids and followed every 3 months now for a median of 10 years. The previous published survey of this group reported outcomes of pain severity, adverse effects, pain relief, satisfaction, mood, problematic opioid use, tolerance, physical dependency, functional status, health-related quality of life (HRQL), immune status and sexual function...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912442/eqtls-weighted-genetic-correlation-analysis-detected-brain-region-differences-in-genetic-correlations-for-complex-psychiatric-disorders
#2
Yan Wen, Feng Zhang, Xiancang Ma, Qianrui Fan, Wenyu Wang, Jiawen Xu, Feng Zhu, Jingcan Hao, Awen He, Li Liu, Xiao Liang, Yanan Du, Ping Li, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo
Background: Psychiatric disorders are usually caused by the dysfunction of various brain regions. Incorporating the genetic information of brain regions into correlation analysis can provide novel clues for pathogenetic and therapeutic studies of psychiatric disorders. Methods: The latest genome-wide association study (GWAS) summary data of schizophrenia (SCZ), bipolar disorder (BIP), autism spectrum disorder (AUT), major depression disorder (MDD), and attention-deficit/hyperactivity disorder (ADHD) were obtained from the Psychiatric GWAS Consortium (PGC)...
June 15, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29909818/individual-responses-of-rodents-in-modelling-of-affective-disorders-and-in-their-treatment-prospective-review
#3
Haim Einat, Itamar Ezer, Nirit Z Kara, Catherine Belzung
IntroductionLack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals. RESULTS: Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past...
June 18, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29909305/the-association-of-duration-and-severity-of-disease-with-executive-function-differences-between-drug-na%C3%A3-ve-patients-with-bipolar-and-unipolar-depression
#4
Tao Yang, Guoqing Zhao, Ruizhi Mao, Jia Huang, Xianrong Xu, Yousong Su, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Fan Wang, Rui Liu, Xing Wang, Zhijia Huang, Yong Wang, Yingyan Hu, Lan Cao, Chengmei Yuan, Zuowei Wang, Raymond W Lam, Jun Chen, Yiru Fang
BACKGROUND: The aims of this study were to investigate the differences in executive function and the relationship with clinical factors between drug-naïve patients with bipolar depression (BDD) and unipolar depression (UPD). METHODS: Drug-naïve patients with BDD, UPD and healthy controls (HC) were recruited (30 cases in each group). All patients were assessed with Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression-17 (HAM-D), and Young Mania Rating Scale (YMRS)...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909303/quality-of-life-in-stabilized-outpatients-with-bipolar-i-disorder-associations-with-resilience-internalized-stigma-and-residual-symptoms
#5
Fabienne Post, Silvia Pardeller, Beatrice Frajo-Apor, Georg Kemmler, Catherine Sondermann, Armand Hausmann, W Wolfgang Fleischhacker, Yuya Mizuno, Hiroyuki Uchida, Alex Hofer
OBJECTIVES: Improving Quality of Life (QoL) is an important objective in the treatment of bipolar disorder. The aim of the current study was to examine to which extent resilience, internalized stigma, and psychopathology are correlated to QoL. METHODS: We recruited 60 outpatients diagnosed with bipolar I disorder according to DSM-IV criteria and 77 healthy control subjects from the general community. In patients, symptoms were quantified by the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Young Mania Rating Scale (YMRS) and internalized stigma by the Internalized Stigma of Mental Illness (ISMI) scale...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909301/intrinsic-functional-neurocircuitry-associated-with-treatment-response-to-transdiagnostic-cbt-in-bipolar-disorder-with-anxiety
#6
Kristen K Ellard, Aishwarya G Gosai, Emily E Bernstein, Navneet Kaur, Lousia G Sylvia, Joan A Camprodon, Darin D Dougherty, Andrew A Nierenberg, Thilo Deckersbach
BACKGROUND: Anxiety in bipolar disorder (BD) exacerbates emotion dysregulation and reduces treatment response. We recently conducted a pilot trial of transdiagnostic CBT to target anxiety and emotion dysregulation in BD adjunctive to pharmacotherapy. Reductions in depression and anxiety symptoms were significantly predicted by baseline levels of neuroticism and perceived affective control, as well as changes over time in emotion regulation skills. The present study investigates mechanism of treatment response by examining the relationship between baseline emotion regulation-related neural circuitry and trial outcomes...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909300/parsing-cyclothymic-disorder-and-other-specified-bipolar-spectrum-disorders-in-youth
#7
Anna Van Meter, Benjamin I Goldstein, Tina R Goldstein, Shirley Yen, Heather Hower, Michael Strober, John A Merranko, Mary Kay Gill, Rasim S Diler, David Axelson, Neal D Ryan, Martin B Keller, Boris Birmaher
OBJECTIVE: Most studies of pediatric bipolar disorder (BP) combine youth who have manic symptoms, but do not meet criteria for BP I/II, into one "not otherwise specified" (NOS) group. Consequently, little is known about how youth with cyclothymic disorder (CycD) differ from youth with BP NOS. The objective of this study was to determine whether youth with a research diagnosis of CycD (RDCyc) differ from youth with operationalized BP NOS. METHOD: Participants from the Course and Outcome of Bipolar Youth study were evaluated to determine whether they met RDCyc criteria...
June 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29905660/resilience-predicts-social-functioning-in-clinically-stable-patients-with-bipolar-disorder
#8
Vasilis P Bozikas, Eleni Parlapani, Evangelos Ntouros, Stavroula I Bargiota, Georgios Floros, Elena I Nazlidou, Georgios Garyfallos
The current study focused on the association between resilience and social functioning in patients with bipolar disorder (BD). Forty clinically stable patients with BD type I and BD type II, as well as 40 healthy controls, matched for age, sex, and educational background were enrolled. Clinical status was assessed by the Montgomery-Åsberg Depression Rating Scale and the Young Mania Rating Scale. Functioning was evaluated by the Mini International Classification of Functioning, Disability and Health rating of activities and participation in mental illnesses, and the Social and Occupational Functioning Scale...
June 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29904359/analysis-of-the-influence-of-micrornas-in-lithium-response-in-bipolar-disorder
#9
Céline S Reinbold, Andreas J Forstner, Julian Hecker, Janice M Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Antonio Benabarre, Susanne Bengesser, Abesh K Bhattacharjee, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Alexandre Dayer, Bruno Étain, Peter Falkai, Louise Frisén, Sébastien Gard, Julie S Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Stéphane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Urban Ösby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A Rouleau, Peter R Schofield, K Oliver Schubert, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Jordan W Smoller, Alessio Squassina, Thomas J Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H Witt, Adam J Wright, L Trevor Young, Peter P Zandi, James B Potash, J Raymond DePaulo, Michael Bauer, Eva Reininghaus, Tomáš Novák, Jean-Michel Aubry, Mario Maj, Bernhard T Baune, Philip B Mitchell, Eduard Vieta, Mark A Frye, Janusz K Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R Wray, John R Kelsoe, Martin Alda, Francis J McMahon, Thomas G Schulze, Marcella Rietschel, Markus M Nöthen, Sven Cichon
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29902821/lithium-clinics-in-berlin-and-dresden-a-50-year-experience
#10
Werner Felber, Michael Bauer, Ute Lewitzka, Bruno Müller-Oerlinghausen
Although lithium's serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and eastern part until 1990...
June 14, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29898625/branched-chain-amino-acids-are-associated-with-metabolic-parameters-in-bipolar-disorder
#11
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29898284/a-within-subject-consideration-of-the-psychotic-spectrum-disorder-concept-in-a-patient-in-remission-associated-with-cortical-gray-matter-recovery
#12
Herbert Y Meltzer, Min Young Sim, Adam Anderson, Christopher Cannistraci, Karu Jayathilake, Daniel Barrett Share, Myung Lee
INTRODUCTION: Psychotic spectrum disorder (PSD) links the syndromes of bipolar disorder, psychotic depression, and schizophrenia, often viewed as unique disorders. AIMS: Application of the PSD concept to a single patient rather than across groups of patients and demonstration of a remarkable remission of schizophrenia phenotype with recovery of gray matter in specific brain regions. RESULTS: We report a woman who experienced discrete, nonoverlapping periods of each of the above syndromes, in the order noted, over a 30-year period, followed by abrupt ending of psychosis and full remission lasting at least 7 years...
July 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29897593/shared-and-distinct-functional-architectures-of-brain-networks-across-psychiatric-disorders
#13
Mingrui Xia, Fay Y Womer, Miao Chang, Yue Zhu, Qian Zhou, Elliot Kale Edmiston, Xiaowei Jiang, Shengnan Wei, Jia Duan, Ke Xu, Yanqing Tang, Yong He, Fei Wang
Brain network alterations have increasingly been implicated in schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). However, little is known about the similarities and differences in functional brain networks among patients with SCZ, BD, and MDD. A total of 512 participants (121 with SCZ, 100 with BD, 108 with MDD, and 183 healthy controls, matched for age and sex) completed resting-state functional magnetic resonance imaging at a single site. Four global measures (the clustering coefficient, the characteristic shortest path length, the normalized clustering coefficient, and the normalized characteristic path length) were computed at a voxel level to quantify segregated and integrated configurations...
April 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29896124/-immune-gate-of-psychopathology-the-role-of-gut-derived-immune-activation-in-major-psychiatric-disorders
#14
REVIEW
Leszek Rudzki, Agata Szulc
Interaction between the gastrointestinal tract (GI) and brain functions has recently become a topic of growing interest in psychiatric research. These multidirectional interactions take place in the so-called gut-brain axis or more precisely, the microbiota-gut-brain axis. The GI tract is the largest immune organ in the human body and is also the largest surface of contact with the external environment. Its functions and permeability are highly influenced by psychological stress, which are often a precipitating factor in the first episode, reoccurrence and/or deterioration of symptoms of psychiatric disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29892702/depressed-female-smokers-have-higher-levels-of-soluble-tumor-necrosis-factor-receptor-1
#15
Mauro Porcu, Regina Célia Bueno Rezende Machado, Mariana Urbano, Waldiceu A Verri, Ana Carolina Rossaneis, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Aim: To examine clinical and biomarkers in depressed female smokers, in order to better clarify the process that link mood disorders, childhood trauma and smoking in women. Methods: The clinical sample comprised women with unipolar or bipolar depression, divided into subgroups of smokers and never-smoker. The control groups comprised two subgroups non-depressed women, separated into smokers and never-smokers. A structured questionnaire was used to assess socio-demographic and clinical data...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29892235/reduced-prefrontal-activation-during-the-tower-of-london-and-verbal-fluency-task-in-patients-with-bipolar-depression-a-multi-channel-nirs-study
#16
Linyan Fu, Dan Xiang, Jiawei Xiao, Lihua Yao, Ying Wang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhongchun Liu
Background: The Tower of London (TOL) task is one of the most commonly used tests for evaluating executive functions, and can indicate planning and problem-solving abilities. The aim of this study was to evaluate hemodynamic changes between the task period and rest period in patients with bipolar depression during the TOL task and the verbal fluency task (VFT) using near-infrared spectroscopy (NIRS). Methods: Forty-three patients with bipolar depression and 32 healthy controls (HCs) matched for sex, age, handedness, and years of education were enrolled in this study...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29888167/chronotype-and-psychiatric-disorders
#17
REVIEW
Liia Kivelä, Marinos Rodolfos Papadopoulos, Niki Antypa
Purpose of Review: Chronotype, reflecting interindividual differences in daily activity patterns and sleep-wake cycles, is intrinsically connected with well-being. Research indicates increased risk of many adverse mental health outcomes for evening-type individuals. Here, we provide an overview of the current evidence available on the relationship between chronotype and psychiatric disorders. Recent Findings: The association between eveningness and depression is well established cross-sectionally, with preliminary support from longitudinal studies...
2018: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/29887899/comparison-of-salivary-testosterone-levels-in-different-phases-of-bipolar-i-disorder-and-control-group
#18
Sabra Mousavizadegan, Mohsen Maroufi
Background: Testosterone is considered as a primary sex hormone, also known as an important anabolic steroid, that may involve in various mental disorders such as bipolar I disorder (BID). The goal of this study was to compare the testosterone salivary levels between different phases of BID and its association with the clinical features of BID. Materials and Methods: In a case-control study, 15 patients in the mania phase, 10 patients in the depression phase, and 16 in the euthymia phase were selected as patient groups...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29886522/aripiprazole-once-monthly-as-maintenance-treatment-for-bipolar-i-disorder-a-52-week-multicenter-open-label-study
#19
Joseph R Calabrese, Na Jin, Brian Johnson, Pedro Such, Ross A Baker, Jessica Madera, Peter Hertel, Jocelyn Ottinger, Joan Amatniek, Hiroaki Kawasaki
BACKGROUND: The long-acting injectable antipsychotic aripiprazole once-monthly 400 mg (AOM 400) was recently approved for maintenance treatment of bipolar I disorder (BP-I). The purpose of this study was to evaluate the safety, tolerability, and efficacy of AOM 400 as long-term maintenance treatment for BP-I. METHODS: This open-label multicenter study evaluated the effectiveness of AOM 400 as maintenance treatment for BP-I by assessing safety and tolerability (primary objective) and efficacy (secondary objective)...
June 10, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29886347/impact-of-group-treatment-for-insomnia-on-daytime-symptomatology-analyses-from-a-randomized-controlled-trial-in-primary-care
#20
Christina Sandlund, Jerker Hetta, Gunnar H Nilsson, Mirjam Ekstedt, Jeanette Westman
BACKGROUND: People typically seek primary health care for daytime symptoms and impairments they experience in association with their insomnia. However, few studies address the question of whether insomnia treatment can improve such symptomatology. OBJECTIVES: To investigate whether a nurse-led group treatment program, based on the techniques of cognitive behavioral therapy for insomnia (CBT-I), improved daytime symptomatology in primary care patients with insomnia...
May 24, 2018: International Journal of Nursing Studies
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