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https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#1
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29666432/genetic-validation-of-bipolar-disorder-identified-by-automated-phenotyping-using-electronic-health-records
#2
Chia-Yen Chen, Phil H Lee, Victor M Castro, Jessica Minnier, Alexander W Charney, Eli A Stahl, Douglas M Ruderfer, Shawn N Murphy, Vivian Gainer, Tianxi Cai, Ian Jones, Carlos N Pato, Michele T Pato, Mikael Landén, Pamela Sklar, Roy H Perlis, Jordan W Smoller
Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the International Cohort Collection for Bipolar Disorder (ICCBD), we previously validated automated EHR-based phenotyping algorithms for BD against in-person diagnostic interviews (Castro et al...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29666369/lithium-associated-transcriptional-regulation-of-crmp1-in-patient-derived-olfactory-neurons-and-symptom-changes-in-bipolar-disorder
#3
Charlee K McLean, Soumya Narayan, Sandra Y Lin, Narayan Rai, Youjin Chung, MariaMananita S Hipolito, Nicola G Cascella, John I Nurnberger, Koko Ishizuka, Akira S Sawa, Evaristus A Nwulia
There is growing evidence that lithium used in the treatment of bipolar disorder (BD) affects molecular targets that are involved in neuronal growth, survival, and maturation, but it remains unclear if neuronal alterations in any of these molecules predict specific symptom changes in BD patients undergoing lithium monotherapy. The goals of this study were to (a) determine which molecular changes in the olfactory neurons of symptomatic patients receiving lithium are associated with antimanic or antidepressant response, and (b) uncover novel intraneuronal regulatory mechanisms of lithium therapy...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29665519/associations-between-cognitive-functioning-mood-symptoms-and-coping-styles-in-older-age-bipolar-disorder
#4
Nadine P G Paans, Annemiek Dols, Hannie C Comijs, Max L Stek, Sigfried N T M Schouws
BACKGROUND: Older age patients with bipolar disorder (OABD) have often passive coping styles, generally considered as detrimental for functioning. The aim of the current study is to identify the contribution of cognitive functioning, subjective cognitive complaints and mood symptoms to passive and active coping styles in older age BD. METHODS: In 90 euthymic patients (age > 60) with BD I or II, we examined coping, neuropsychological profile including memory, attention, executive function and fluency, subjective cognitive complaints and mood symptoms...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#5
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29664050/association-between-perceived-stressfulness-of-stressful-life-events-and-the-suicidal-risk-in-chinese-patients-with-major-depressive-disorder
#6
Jing-Yu Lin, Yu Huang, Yun-Ai Su, Xin Yu, Xiao-Zhen Lyu, Qi Liu, Tian-Mei Si
Background: Patients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese patients with MDD. Methods: In total, 1029 patients with MDD were included from nine psychiatric hospitals to evaluate the impact of SLEs on suicidal risk...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29658287/perspectives-on-providing-and-receiving-preventive-health-care-from-primary-care-providers-and-their-patients-with-mental-illnesses
#7
Scott P Stumbo, Bobbi Jo H Yarborough, Micah T Yarborough, Carla A Green
PURPOSE: Individuals with mental illnesses have higher morbidity rates and reduced life expectancy compared to the general population. Understanding how patients and providers perceive the need for prevention, as well as the barriers and beliefs that may contribute to insufficient care, are important for improving service delivery tailored to this population. DESIGN: Cross-sectional; mixed methods. SETTING: An integrated health system and a network of federally qualified health centers and safety net clinics...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29656414/add-on-memantine-treatment-for-bipolar-ii-disorder-comorbid-with-alcohol-dependence-a-12-week-follow-up-study
#8
Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
BACKGROUND: Bipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproate (VPA) treatment ameliorated clinical symptoms, reduced alcohol use and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29656268/the-development-and-validation-of-a-short-version-of-the-33-item-hypomania-checklist-hcl-33
#9
Yuan-Yuan Wang, Yuan Feng, Dan-Dan Xu, Wei Huang, Ines H I Chow, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Gang Wang, Yu-Tao Xiang
BACKGROUND: The misdiagnosis of bipolar disorder (BD) as major depressive disorder (MDD) is common in clinical practice and may result in inappropriate treatment. The 33-item Hypomania Checklist (HCL-33) is a newly developed screening scale for BD with satisfactory psychometric properties. In this study, a short version of the HCL-33 was developed and validated to discriminate between BD and MDD. METHOD: All interviews were conducted in a major psychiatric hospital in China...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29655654/factorial-structure-and-familial-aggregation-of-the-hypomania-checklist-32-hcl-32-results-of-the-nimh-family-study-of-affective-spectrum-disorders
#10
Jennifer Glaus, Anna Van Meter, Lihong Cui, Ciro Marangoni, Kathleen R Merikangas
BACKGROUND: There is substantial evidence that bipolar disorder (BD) manifests on a spectrum rather than as a categorical condition. Detection of people with subthreshold manifestations of BD is therefore important. The Hypomania Checklist-32 (HCL-32) was developed as a tool to identify such people. PURPOSE: The aims of this paper were to: (1) investigate the factor structure of HCL-32; (2) determine whether the HCL-32 can discriminate between mood disorder subtypes; and (3) assess the familial aggregation and cross-aggregation of hypomanic symptoms assessed on the HCL with BD...
April 3, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29653349/the-role-of-lifetime-anxiety-history-in-the-course-of-bipolar-spectrum-disorders
#11
Madison K Titone, Rachel D Freed, Jared K O'Garro-Moore, Andrew Gepty, Tommy H Ng, Jonathan P Stange, Lyn Y Abramson, Lauren B Alloy
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young adults (aged 17-26) with milder forms of BSDs (i.e., bipolar-II, cyclothymia, BD-NOS). First, bivariate analyses assessed differences in baseline clinical characteristics between participants with and without DSM-IV anxiety diagnoses...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29653348/increased-oxidative-stress-in-the-mitochondria-isolated-from-lymphocytes-of-bipolar-disorder-patients-during-depressive-episodes
#12
Samira S Valvassori, Daniela V Bavaresco, Gustavo Feier, Kelen Cechinel-Recco, Amanda V Steckert, Roger B Varela, Cenita Borges, Milena Carvalho-Silva, Lara M Gomes, Emílio L Streck, João Quevedo
The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#13
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651656/using-lithium-in-children-and-adolescents-with-bipolar-disorder-efficacy-tolerability-and-practical-considerations
#14
REVIEW
B Grant, J A Salpekar
Lithium has been an intriguing treatment option in psychiatry for over a century. While seemingly just a simple elemental compound, it has powerful treatment effects for both depression and bipolar disorder. The evidence base for treatment of pediatric bipolar disorder is relatively small, but, in recent years, additional clinical trial data have enabled lithium to re-emerge as a valuable and, in many cases, preferred treatment. Pharmacologically, lithium is complex, with varied effects at both intracellular and extracellular levels...
April 12, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29649810/female-gender-marital-and-family-problems-and-feelings-of-guilt-are-related-to-self-immolation-suicide-attempts
#15
Mohammad Ahmadpanah, Amir Hosein Rahighi, Mohammad Haghighi
BACKGROUND: Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western Iran specifically. Here, we report sociodemographic, psychological, and psychiatric characteristics of patients attempting self-immolation (PSIs), compared to patients with accident burns (PABs). METHOD: Patients referred to the Burns Emergency Unit of the Besat Hospital (Hamadan, Iran) were enrolled in the present study between winter 2015 and summer 2016...
April 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29649674/are-there-clinical-and-neurophysiologic-predictive-factors-for-a-positive-response-to-hf-rtms-in-patients-with-treatment-resistant-depression
#16
Anna Poleszczyk, Maria Rakowicz, Tadeusz Parnowski, Jakub Antczak, Łukasz Święcicki
Better selection of patients with treatment-resistant depression for high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) would make the procedure more efficient. The objective of this study was to search for clinical and neurophysiologic predictors of therapeutic response with a special focus on the bipolar population. Forty patients (30 bipolar) underwent 20 daily sessions of HF-rTMS. Clinical outcome measures included the 21-item Hamilton Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impression, and the Patient Global Impression...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29648599/polycystic-ovary-syndrome-is-associated-with-adverse-mental-health-and-neurodevelopmental-outcomes
#17
Thomas R Berni, Christopher L Morgan, Ellen R Berni, D Aled Rees
Context: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility but the effects on mental health and child neurodevelopment are unclear. Objectives: To determine if (i) there is an association between PCOS and psychiatric outcomes, and (ii) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS. Design: Data were extracted from the Clinical Practice Research Datalink...
April 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29643339/desynchronization-of-diurnal-rhythms-in-bipolar-disorder-and-borderline-personality-disorder
#18
Oliver Carr, Kate E A Saunders, Amy C Bilderbeck, Athanasios Tsanas, Niclas Palmius, John R Geddes, Russell Foster, Maarten De Vos, Guy M Goodwin
It has long been proposed that diurnal rhythms are disturbed in bipolar disorder (BD). Such changes are obvious in episodes of mania or depression. However, detailed study of patients between episodes has been rare and comparison with other psychiatric disorders rarer still. Our hypothesis was that evidence for desynchronization of diurnal rhythms would be evident in BD and that we could test the specificity of any effect by studying borderline personality disorder (BPD). Individuals with BD (n = 36), BPD (n = 22) and healthy volunteers (HC, n = 25) wore a portable heart rate and actigraphy device and used a smart-phone to record self-assessed mood scores 10 times per day for 1 week...
April 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29643263/health-state-utilities-for-patient-s-current-health-from-bipolar-type-i-disorder
#19
Masoumeh Banihashemian, Arash Rashidian, Faeze Gholamian, Mahboubeh Parsaeian, Najmeh Moradi, Homayoun Amini
BACKGROUND: Bipolar Type I Disorder (BID) is a disabling mental disorder among young adults that places enormous psychological, social, and economic burdens on patients, their families, and health care systems and decreases quality of life (QOL). Few studies have investigated the quality-adjusted life-years (QALY), health state preferences, and utilities in patients with BID. AIM OF STUDY: The aim of this study was to elicit health state utilities for current health among a sample of individuals with BID irrespective of their clinical conditions at the time of evaluation...
March 1, 2018: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/29628501/excitatory-and-inhibitory-synaptic-dysfunction-in-mania-an-emerging-hypothesis-from-animal-model-studies
#20
REVIEW
Yeunkum Lee, Yinhua Zhang, Shinhyun Kim, Kihoon Han
Bipolar disorder (BD) is a common psychiatric disorder characterized by recurrent mood swings between depression and mania, and is associated with high treatment costs. The existence of manic episodes is the defining feature of BD, during which period, patients experience extreme elevation in activity, energy, and mood, with changes in sleep patterns that together severely impair their ability to function in daily life. Despite some limitations in recapitulating the complex features of human disease, several rodent models of mania have been generated and characterized, which have provided important insights toward understanding its underlying pathogenic mechanisms...
April 9, 2018: Experimental & Molecular Medicine
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