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https://www.readbyqxmd.com/read/28535448/bipolar-postpartum-depression-an-update-and-recommendations
#1
REVIEW
Verinder Sharma, Minakshi Doobay, Christine Baczynski
BACKGROUND: Over the past few years there has been a surge of interest in the study of bipolar postpartum depression (PPD); however, questions remain about its prevalence, screening, clinical features, and treatment. METHODS: Three electronic databases, MEDLINE/PubMed (1966-2016), PsycINFO (1806-2016), and the Cochrane Database of Systematic Reviews, were searched using a combination of the keywords bipolar, depression, postpartum, peripartum, prevalence, screening, diagnosis, treatment, drugs, and psychotherapy...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28534186/modifiable-and-non-modifiable-factors-associated-with-functional-impairment-during-the-inter-episodic-periods-of-bipolar-disorder
#2
Andrea Murru, Isabella Pacchiarotti, Norma Verdolini, Maria Reinares, Carla Torrent, Pierre-Alexis Geoffroy, Frank Bellivier, Pierre-Michel Llorca, Eduard Vieta, Ludovic Samalin
The chronic, long-term evolution of bipolar disorder (BD) requires a careful clinical characterization with prognostic implications in terms of symptom and functional control. The OPTHYMUM multicenter study was conducted in France with the objective of evaluating residual symptoms on overall functioning of BD patients during inter-episodic period. The aims of the present study were to identify the potentially modifiable (e.g., treatable) and non-modifiable variables associated with functional impairment during the inter-episodic periods of BD...
May 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#3
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
April 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28531264/cariprazine-exhibits-anxiolytic-and-dopamine-d3-receptor-dependent-antidepressant-effects-in-the-chronic-stress-model
#4
Vanya Duric, Mounira Banasr, Tina Franklin, Ashley Lepack, Nika Adham, Béla Kiss, István Gyertyán, Ronald S Duman
Background: Cariprazine, a D3-preferring dopamine D2/D3 receptor partial agonist, is a new antipsychotic drug recently approved in the US for the treatment of schizophrenia and bipolar mania. We recently demonstrated that cariprazine also has significant anti-anhedonic-like effects in rats subjected to chronic stress; however, the exact mechanism of action for cariprazine's antidepressant-like properties is not known. Thus, in this study we examined whether the effects of cariprazine are mediated by dopamine D3 receptors...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28529805/physical-activity-modulates-common-neuroplasticity-substrates-in-major-depressive-and-bipolar-disorder
#5
REVIEW
Cristy Phillips
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28529394/positive-emotion-specificity-and-mood-symptoms-in-an-adolescent-outpatient-sample
#6
June Gruber, Anna Van Meter, Kirsten E Gilbert, Eric A Youngstrom, Jennifer Kogos Youngstrom, Norah C Feeny, Robert L Findling
Research on positive emotion disturbance has gained increasing attention, yet it is not clear which specific positive emotions are affected by mood symptoms, particularly during the critical period of adolescence. This is especially pertinent for identifying potential endophenotypic markers associated with mood disorder onset and course. The present study examined self-reported discrete positive and negative emotions in association with clinician-rated manic and depressive mood symptoms in a clinically and demographically diverse group of 401 outpatient adolescents between 11-18 years of age...
June 2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/28528563/chronic-obstructive-pulmonary-disease-associated-with-increased-risk-of-bipolar-disorder
#7
Vincent Yi-Fong Su, Li-Yu Hu, Chiu-Mei Yeh, Huey-Ling Chiang, Cheng-Che Shen, Kun-Ta Chou, Tzeng-Ji Chen, Ti Lu, Cheng-Hwai Tzeng, Chia-Jen Liu
Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of chronic obstructive pulmonary disease (COPD). However, the relationship between COPD and subsequent bipolar disorder remains unclear. From January 1, 2000, we identified adult patients with COPD from the Taiwan National Health Insurance Research Database. A nationwide population-based study was conducted; 46,778 COPD patients and 46,778 age-, sex-, and comorbidity-matched subjects between 2000 and 2011 were enrolled...
May 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28528241/peripheral-zinc-and-neopterin-concentrations-are-associated-with-mood-severity-in-bipolar-disorder-in-a-gender-specific-manner
#8
Caitlin E Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Shannon L Kelleher, Erika F H Saunders
Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28525775/the-association-between-systemic-lupus-erythematosus-and-bipolar-disorder%C3%A2-%C3%A2-a-big-data-analysis
#9
S Tiosano, Z Nir, O Gendelman, D Comaneshter, H Amital, A D Cohen, D Amital
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has a wide variety of physical manifestations, including neuropsychiatric features. Bipolar disorder (BD) is a chronic, episodic illness, that may present as depression or as mania. The objective of this study was to investigate the association between SLE and BD using big data analysis methods. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of BD in a cross-sectional study...
April 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28525601/too-fast-or-too-slow-time-and-neuronal-variability-in-bipolar-disorder-a-combined-theoretical-and-empirical-investigation
#10
Georg Northoff, Paola Magioncalda, Matteo Martino, Hsin-Chien Lee, Ying-Chi Tseng, Timothy Lane
Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie, self-time, and outer time, ie, world-time, that desynchronize or dissociate from each other in BP: inner time speed is abnormally slow (as in depression) or fast (as in mania) and, by taking on the role as default-mode function, impacts and modulates the perception of outer time speed in an opposite way, ie, as too fast in depression and too slow in mania...
May 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28515818/pharmacogenomic-testing-for-psychotropic-medication-selection-a-systematic-review-of-the-assurex-genesight-psychotropic-test
#11
(no author information available yet)
BACKGROUND: A large proportion of the Ontario population lives with a diagnosed mental illness. Nearly 5% of Ontarians have major depressive disorder, and another 5% have another type of depressive disorder, bipolar disorder, schizophrenia, anxiety, or some other disorder not otherwise specified. Medications are commonly used to treat mental illness, but choosing the right medication for each patient is challenging, and more than 40% of patients discontinue their medication within 90 days because of adverse effects or lack of response...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28509900/altered-expression-of-bdnf-bdnf-pro-peptide-and-their-precursor-probdnf-in-brain-and-liver-tissues-from-psychiatric-disorders-rethinking-the-brain-liver-axis
#12
B Yang, Q Ren, J-C Zhang, Q-X Chen, K Hashimoto
Brain-derived neurotrophic factor (BDNF) has a role in the pathophysiology of psychiatric disorders. The precursor proBDNF is converted to mature BDNF and BDNF pro-peptide, the N-terminal fragment of proBDNF; however, the precise function of these proteins in psychiatric disorders is unknown. We sought to determine whether expression of these proteins is altered in the brain and peripheral tissues from patients with psychiatric disorders. We measured protein expression of proBDNF, mature BDNF and BDNF pro-peptide in the parietal cortex, cerebellum, liver and spleen from control, major depressive disorder (MDD), schizophrenia (SZ) and bipolar disorder (BD) groups...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#13
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28506924/olfactory-and-gustatory-functions-in-bipolar-disorders-a-systematic-review
#14
REVIEW
Francois Kazour, Sami Richa, Thomas Desmidt, Mathieu Lemaire, Boriana Atanasova, Wissam Elhage
Olfactory and gustatory dysfunction have been described in different psychiatric disorders. Several studies have found gustatory and olfactory function change in Bipolar Disorders with various results. The aim of this study is to have a systematic review of studies evaluating gustatory and olfactory function in bipolar disorders. After a systematic search, 15 studies on olfaction and 5 studies on taste were included in this review. The UPSIT and Sniffin' Sticks were the most used tests to evaluate smell. Some studies on olfaction described dysfunction in smell identification as potential markers for Bipolar disorders...
May 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28506220/does-the-number-of-previous-mood-episodes-moderate-the-relationship-between-alcohol-use-smoking-and-mood-in-bipolar-outpatients
#15
Wendela G Ter Meulen, Jan van Zaane, Stasja Draisma, Aartjan T F Beekman, Ralph W Kupka
BACKGROUND: Evidence suggests that alcohol use and smoking are negatively associated with mood in bipolar disorders (BD). It is unknown if this relationship is moderated by the number of previous mood episodes. Therefore, this paper aims to examine whether the number of previous mood episodes moderates the relationship between alcohol use and smoking, and mood. METHOD: This study assessed the outcomes of 108 outpatients with BD I and II in a prospective observational cohort study...
May 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28505469/the-association-between-immune-markers-and-recent-suicide-attempts-in-patients-with-serious-mental-illness-a-pilot-study
#16
Faith Dickerson, Maria Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina Savage, Lucy Schweinfurth, Cassie Stallings, Kevin Sweeney, Armin Alaedini, Melanie Uhde, Emily Severance, Holly C Wilcox, Robert Yolken
Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP)...
May 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28504840/clinical-utility-of-a-short-resting-state-mri-scan-in-differentiating-bipolar-from-unipolar-depression
#17
M Li, T Das, W Deng, Q Wang, Y Li, L Zhao, X Ma, Y Wang, H Yu, X Li, Y Meng, L Palaniyappan, T Li
OBJECTIVE: Depression in bipolar disorder (BipD) requires a therapeutic approach that is from treating unipolar major depressive disorder (UniD), but to date, no reliable methods could separate these two disorders. The aim of this study was to establish the clinical validity and utility of a non-invasive functional MRI-based method to classify BipD from UniD. METHOD: The degree of connectivity (degree centrality or DC) of every small unit (voxel) with every other unit of the brain was estimated in 22 patients with BipD and 22 age, gender, and depressive severity-matched patients with UniD and 22 healthy controls...
May 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28503892/the-ethics-of-clinical-trials-research-in-severe-mood-disorders
#18
Allison C Nugent, Franklin G Miller, Ioline D Henter, Carlos A Zarate
Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research...
May 15, 2017: Bioethics
https://www.readbyqxmd.com/read/28503402/physical-exercise-for-treatment-of-mood-disorders-a-critical-review
#19
C M Hearing, W C Chang, K L Szuhany, T Deckersbach, A A Nierenberg, L G Sylvia
PURPOSE OF THE REVIEW: The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population...
December 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/28503114/antidepressant-induced-dopamine-receptor-dysregulation-a-valid-animal-model-of-manic-depressive-illness
#20
REVIEW
Francesca Demontis, Francesca Serra, Gino Serra
BACKGROUND: Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder...
April 2017: Current Neuropharmacology
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