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Laetitia Piane, Marie-Laure Théron, Marcel Aumann, Catherine Trumel
A 9-year-old, female Maltese dog was referred to the Veterinary School of Toulouse with a 2-day history of anorexia and weakness. On clinical examination, the dog had hyperthermia (39.7°C), abdominal discomfort, and polypnea. Significant laboratory findings included pigmenturia, hyperbilirubinemia, hypercreatininemia, hyperfibrinogenemia, abnormal Snap canine pancreas-specific lipase, and pancytopenia with a nonregenerative anemia. A peripheral blood smear revealed numerous intraerythrocytic large Babesia but no polychromasia...
October 18, 2016: Veterinary Clinical Pathology
Hui Shao, Yang Yang, Ai-Ping Qi, Pian Hong, Guang-Xi Zhu, Xin-Yu Cao, Wei-Gang Ji, Zhi-Ru Zhu
Temporal lobe epilepsy (TLE) is one of the most refractory types of adult epilepsy, and treatment options remain unsatisfactory. Gastrodin (GAS), a phenolic glucoside used in Chinese herbal medicine and derived from Gastrodia elata Blume, has been shown to have remarkable anticonvulsant effects on various models of epilepsy in vivo. However, the mechanisms of GAS as an anticonvulsant drug remain to be established. By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms...
October 14, 2016: Neurochemical Research
Huogen Yu, Pian Xiao, Jing Tian, Fazhou Wang, Jiaguo Yu
The preferential adsorption of targeted contaminants on a photocatalyst surface is highly required to realize its photocatalytic selective decomposition in a complex system. To realize the tunable preferential adsorption, altering the surface charge or polarity property of photocatalysts has widely been reported. However, it is quite difficult for a modified photocatalyst to realize the simultaneously preferential adsorption for both cationic and anionic dyes. In this study, to realize the selective adsorption for both cationic and anionic dyes on a photocatalyst surface, the negative reduced graphene oxide (rGO) nanosheets and positive phenylamine (PhNH2) molecules are successfully loaded on the TiO2 surface (PhNH2/rGO-TiO2) with spatially separated adsorption sites, where the negative rGO and positive PhNH2 molecules work as the preferential adsorption sites for cationic and anionic dyes, respectively...
October 13, 2016: ACS Applied Materials & Interfaces
Laetitia Piane, Karen M Young, Lena Giraud, Nathalie Bourges-Abella, Catherine Trumel
BACKGROUND: Erroneously high reticulocyte counts (pseudoreticulocytosis) have been reported in dogs with leukemia. Pseudoreticulocytosis and an abnormal reticulocyte profile were observed in a dog with large form babesiosis presented at our institution. OBJECTIVES: The aims of this retrospective study were to determine if dogs with babesiosis and other dogs had abnormal reticulocyte profiles, and to correlate these profiles with the primary diagnosis. METHODS: All canine CBCs obtained with the Sysmex XT-2000iV or Procyte DX were reviewed...
October 4, 2016: Veterinary Clinical Pathology
Chen Zhang, Bingfei Xu, Pian Liu
Breast cancer is one of the leading causes of death for women worldwide. Among various subtypes of breast cancer, human epidermal growth factor receptor 2 (HER2)-positive and phosphatase and tensin homolog (PTEN) loss breast cancer is a cause of great concern in terms of its resistance to HER2-targeted therapies and its poor prognosis. Phosphatidylinositol 3-kinase (PI3K)/AKT hyperphosphorylation is considered one of key mechanisms leading to this resistance, thus combination therapy of PI3K inhibitors and HER2 antibodies is promising for overcoming this problem, and more specific regimens should be designed in this age of precision medicine...
September 17, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
He-Lin Xu, Kai-Li Mao, Cui-Tao Lu, Zi-Liang Fan, Jing-Jing Yang, Jie Xu, Pian-Pian Chen, De-Li ZhuGe, Bi-Xin Shen, Bing-Hui Jin, Jian Xiao, Ying-Zheng Zhao
Intratumoral drug delivery (IT) is an inherently appealing approach for concentrating toxic chemotherapies at the site of action. However, for most chemotherapies, poor tumor penetration and short retention at the administration site limit their anti-tumor effects. In this work, we describe permeable nanoparticles (NPs) prepared with a novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL). The nanoparticles (NPs) of VES-g-ε-PLL exhibited an ultra-small hydrodynamic diameter (20...
November 2016: Biomaterials
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
OBJECTIVE: There is no specific clinical tool for physicians to detect psychosocial and physical distress or health care need in patients with recurrent respiratory papillomatosis (RRP). The main aim of this study is to validate the RRP-adapted Distress Thermometer and Problem List (DT&PL). STUDY DESIGN: Prospective cross-sectional questionnaire research. SETTING: Academic tertiary care medical centers in Groningen, Netherlands, and Helsinki, Finland...
September 6, 2016: Otolaryngology—Head and Neck Surgery
Minyue R Dai, Daniel K Ho, Lihua Huang, Ryan L Quock, Catherine M Flaitz
PURPOSE: To characterize traditional Chinese medicine (TCM) use, emphasizing herbal remedies, for oral conditions among two Chinese pediatric populations in the United States. METHODS: 318 unique ethnic Chinese parental units in Houston and Boston with children younger than 12 years old were interviewed for themselves and their children. Questionnaire included age, gender, duration in the United States, frequency of TCM use, and the five selected oral conditions for which TCM agents might be used...
2016: Pediatric Dentistry
Xiao-Wei Zhu, Yong Wang, Yi-Hua Wei, Pian-Pian Zhao, Xiao-Bo Wang, Jing-Jing Rong, Wen-Ying Zhong, Xing-Wei Zhang, Li Wang, Hou-Feng Zheng
We performed a meta analysis to assess the relationship of FCGRs polymorphisms with the risk of SLE. Thirty-five articles (including up to 5741 cases and 6530 controls) were recruited for meta-analysis. The strongest association was observed between FCGR2B rs1050501 and SLE under the recessive genotypic model of C allele in the overall population (CC vs CT/TT, OR = 1.754, 95%CI: 1.422-2.165, P = 1.61 × 10(-7)) and in Asian population (CC vs CT/TT, OR = 1.784, 95%CI; 1.408-2.261, P = 1.67 × 10(-6))...
2016: Scientific Reports
Julius Z Wermelt, Richard K Ellerkmann
Emergence Delirium in children after general anesthesia is a common and self limitating event. Although it might be seen as being harmless it can cause other serious complications and might leave both parents and other caregivers with a negative impression behind. Although the cause may still not be clear, potential predictors can be named: preschool age, the use of fast acting volatile anesthestics, higher preoperative anxiety levels and postoperative pain.A child-focused approach to reduce preoperative anxiety focusing on distraction methods rather than pharmacological sedation may be the key as well as sufficient postoperative pain control and the use of total intravenous anesthesia...
July 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Hongya Niu, Wei Hu, Daizhou Zhang, Zhijun Wu, Song Guo, Wei Pian, Wenjing Cheng, Min Hu
Chemical composition, morphology, size and mixture of fine particles were measured in a heavy haze and the post-haze air in Beijing in January 2012. With the occurrence of haze, the concentrations of gaseous and particulate pollutants including organics, sulfate, nitrate, and ammonium grew gradually. The hourly averaged PM2.5 concentration increased from 118μgm(-3) to 402μgm(-3) within 12h. In contrast, it was less than 10μgm(-3) in the post-haze air. Occupying approximately 46% in mass, organics were the major component of PM1 in both the haze and post-haze air...
November 15, 2016: Science of the Total Environment
Rodrigo Carrasco-Moro, Juan Martínez-San Millán, Héctor Pian
The inflammatory pseudotumour (IPT) is a non-neoplastic entity of unknown origin, and is characterised by a proliferation of connective tissue and a polyclonal inflammatory infiltrate. Central nervous system involvement is uncommon, and usually represents a diagnostic and therapeutic challenge even for the experienced clinician. This reports deals with the case of a 56year-old woman diagnosed with a giant, infiltrating mass centred in the left cavernous sinus, who had a rapid clinical and radiological response to steroid therapy...
July 12, 2016: Neurocirugía
He-Lin Xu, Kai-Li Mao, Yin-Ping Huang, Jing-Jing Yang, Jie Xu, Pian-Pian Chen, Zi-Liang Fan, Shuang Zou, Zheng-Zheng Gao, Jia-Yu Yin, Jian Xiao, Cui-Tao Lu, Bao-Lin Zhang, Ying-Zheng Zhao
Multifunctional nanoparticles capable of the specific delivery of therapeutics to diseased cells and the real-time imaging of these sites have the potential to improve cancer treatment through personalized therapy. In this study, we have proposed a multifunctional nanoparticle that integrate magnetic targeting, drug-carrier functionality and real-time MRI imaging capabilities in one platform for the theranostic treatment of tumors. The multifunctional nanoparticle was designed with a superparamagnetic iron oxide core and a multifunctional shell composed of PEG/PEI/polysorbate 80 (Ps 80) and was used to encapsulate DOX...
August 7, 2016: Nanoscale
Lin Li, Yaya Pian, Shaolong Chen, Huaijie Hao, Yuling Zheng, Li Zhu, Bin Xu, Keke Liu, Min Li, Hua Jiang, Yongqiang Jiang
Vascular leakage frequently occurs in patients with severe Staphylococcus aureus infection. However, the mechanism underlying S. aureus infection-induced vascular leakage remains unclear. Here, we identified the S. aureus virulence factor phenol-soluble modulin (PSM)α4 from the culture supernatant of strain USA300 as a stimulator of heparin-binding protein (HBP) release from polymorphonuclear neutrophils (PMNs) and demonstrated that PSMα4-induced HBP release from PMNs leads to vascular leakage. PSMα4 appeared less cytolytic than PSMα1-3 and was insensitive to lipoproteins; it significantly increased myeloperoxidase and elastase release from PMNs and cell surface CD63 expression in PMNs...
2016: Scientific Reports
Roberto Berretta, Federico Marchesi, Lavinia Volpi, Giulio Ricotta, Michela Monica, Giulio Sozzi, Maurizio Di Serio, Daniele Mautone
OBJECTIVE: To evaluate clinical outcomes and postoperative quality of life in patients affected by locally advanced ovarian cancer who underwent pelvic posterior exenteration with Hudson-Delle Piane radical retrograde hysterectomy. MATERIALS AND METHODS: Our study was done on a retrospective cohort using data from 22 patients who underwent surgery between 2010 and 2014 at the Gynecological Oncologic Center of Parma, Parma, Italy. RESULTS: Residual disease after surgery (Sugarbacker index) was absent (CC-0) in 68% of cases...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
Wenjing Pian, Christopher Sg Khoo, Yun-Ke Chang
BACKGROUND: People are increasingly accessing health-related social media sites, such as health discussion forums, to post and read user-generated health information. It is important to know what criteria people use when deciding the relevance of information found on health social media websites, in different situations. OBJECTIVE: The study attempted to identify the relevance criteria that people use when browsing a health discussion forum, in 3 types of use contexts: when seeking information for their own health issue, when seeking for other people's health issue, and when browsing without a particular health issue in mind...
2016: Journal of Medical Internet Research
Haitao Huang, Min Li, Pian Liu, Lin Jin, Hui Wang, Deyuan Shen
Gold nanorods (GNRs) with an average aspect ratio of 15 were experimentally exploited as the 2 μm saturable absorber in a laser diode pumped Tm:YAG laser for the first time, to the best of our knowledge. Q-switched pulses with a maximum average output power of 380 mW, a minimum pulse width of 796 ns, and a pulse repetition rate of 77 kHz were achieved under the LD pump power of 6.2 W. Our results indicate that GNRs with a large aspect ratio are promising saturable absorbers in the 2 μm wavelength region...
June 15, 2016: Optics Letters
P Iglesias, V Rodríguez-Berrocal, H Pian, J J Díez
No abstract text is available yet for this article.
August 2016: QJM: Monthly Journal of the Association of Physicians
Yu Fu, Jin-Xia Ni, Federico Marmori, Qi Zhu, Cheng Tan, Ji-Ping Zhao
OBJECTIVE: By observing body surface temperature variation of the intermediate structures of the Lung (Fei) and Large Intestine (Dachang) exterior-interior relationship in asthmatic patients, to investigate the pathological response on the pathway of channels and to substantiate the objective existence of the intermediary structures. METHODS: The study included 60 subjects meeting the bronchial asthma inclusion criteria (experimental group) and 60 healthy subjects (normal control group)...
June 9, 2016: Chinese Journal of Integrative Medicine
Feng Gao, Kun Wang, Ying Liu, Yunping Chen, Pian Chen, Zhenying Shi, Jie Luo, Daqing Jiang, Fengfeng Fan, Yingguo Zhu, Shaoqing Li
Strategies to increase rice productivity to meet the global demand have been the main concern of breeders around the world. Although a growing number of functional genes related to crop yield have been characterized, our understanding of its associated regulatory pathways is limited. Using rice as a model, we find that blocking miR396 greatly increases grain yield by modulating development of auxiliary branches and spikelets through direct induction of the growth regulating factor 6 (OsGRF6) gene. The upregulation of OsGRF6 results in the coordinated activation of several immediate downstream biological clades, including auxin (IAA) biosynthesis, auxin response factors, and branch and spikelet development-related transcription factors...
2015: Nature Plants
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