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https://www.readbyqxmd.com/read/30407961/simulation-based-education-to-train-learners-to-speak-up-in-the-clinical-environment-results-of-a-randomized-trial
#1
Ceyda Oner, Nelli Fisher, Fouad Atallah, Mary Ann Son, Peter Homel, Katerina Mykhalchenko, Howard Minkoff
INTRODUCTION: Assertiveness is essential for communication and/or speaking up. We performed a randomized trial to assess the effectiveness of assertiveness/advocacy/CUS/two-challenge rule (AACT) simulation-based education for labor and delivery as well as postpartum nurses. We aimed to determine whether this training would improve labor and delivery and postpartum nurses speaking up in the clinical setting. METHODS: We conducted a randomized controlled trial among nurses on labor and delivery and postpartum units...
November 7, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/30389154/modulation-of-hypersensitivity-to-oxidative-dna-damage-in-atm-defective-cells-induced-by-potassium-bromate-by-inhibition-of-the-poly-adp-ribose-polymerase-parp
#2
P Mosesso, M Piane, G Pepe, S Cinelli, L Chessa
The ataxia telangiectasia mutated (ATM) protein is a pivotal multifunctional protein kinase predominantly involved in DNA damage response, as well as in maintaining overall functional integrity of the cells. Apart from playing its major role in regulating the cellular response to DNA damage, ATM, when mutated, can additionally determine oxidative stress, metabolic syndrome, mitochondrial dysfunction and neurodegeneration. In the present paper we aim to investigate the levels of oxidative stress potentially induced by the oxidizing rodent renal carcinogen KBrO3 in ATM-defective lymphoblastoid cell lines (LCLs) established from four classical AT patients (with different ATM mutations), one AT variant with reduced hypersensitivity to X rays, obligate AT heterozygotes and wild type intrafamilial control...
December 2018: Mutation Research
https://www.readbyqxmd.com/read/30365078/rapamycin-induces-autophagy-to-alleviate-acute-kidney-injury-following-cerebral-ischemia-and-reperfusion-via-the-mtorc1-atg13-ulk1-signaling-pathway
#3
Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang
Acute kidney injury (AKI) is a clinically common and severe complication of ischemia‑reperfusion (I/R), associated with high morbidity and mortality rates, and prolonged hospitalization. Rapamycin is a type of macrolide, primarily used for anti‑rejection therapy following organ transplantation and the treatment of autoimmune diseases. Rapamycin has been identified to exert a protective effect against AKI induced by renal I/R as an autophagy inducer. However, whether rapamycin preconditioning may relieve AKI following cerebral I/R (CIR) remains to be fully elucidated...
October 24, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30326837/discovering-the-dark-matters-in-expression-data-of-mirna-based-on-the-mirna-mrna-and-mirna-lncrna-networks
#4
Cong Pian, Guangle Zhang, Sanling Wu, Fei Li
BACKGROUND: Since miRNAs can play important roles in different cancer types, how to discover cancer related miRNAs is an important issue. In general, the miRNAs with differential expression is the focus of attention. However, some important cancer related miRNAs are not excavated by differential expression analysis. We take this type of miRNAs as 'dark matters' (DM-miRNA). It is our great interests to develop an algorithm to discover DM-miRNAs. RESULTS: An effective method was developed to find DM-miRNAs...
October 16, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/30296374/structural-and-computational-assessment-of-the-influence-of-wet-chemical-post-processing-of-the-al-substituted-cubic-li-7-la-3-zr-2-o-12
#5
Robert Kun, Frederieke Langer, Massimo Delle Piane, Saneyuki Ohno, Wolfgang G Zeier, Michael Gockeln, Lucio Colombi Ciacchi, Matthias Busse, István Fekete
Li7 La3 Zr2 O12 (LLZO) and related compounds are considered as promising candidates for future all-solid-state Li-ion battery applications. Still, the processing of those materials into thin membranes with the right stoichiometry and crystal structure is difficult and laborious. The sensitivity of the Li-ion conductive garnets against moisture and the associated Li+ /H+ cation exchange makes their processing even more difficult. Formulation of suitable polymer/ceramic hybrid solid state electrolytes could be a prosperous way to reach the future large scale production of solid state Li-ion batteries...
October 31, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30266246/cystic-meningiomas-radiological-and-pathological-correlation-with-surgical-implications
#6
Rodrigo Carrasco Moro, Herbert D Jiménez Zapata, Héctor Pian Arias, Juan S Martínez San Millán, María A Martínez Rodrigo, José M Pascual Garvi
INTRODUCTION: Meningiomas associating prominent cystic changes (CM) have challenged neurosurgeons since the beginning of this surgical discipline. We present the experience in the diagnostic and therapeutic management of this entity in our institution. MATERIAL AND METHODS: A review of our patient database was carried out, searching for those CM that were operated on in the last 15 years. Relevant clinical data were recorded and analyzed for each case, with special emphasis in the correlation of radiological and pathological findings...
September 25, 2018: Neurocirugía
https://www.readbyqxmd.com/read/30265385/multidisciplinary-planning-teams-crucial-for-creating-effective-simulation-scenarios
#7
Maureen Hemingway, May Pian-Smith
No abstract text is available yet for this article.
October 2018: AORN Journal
https://www.readbyqxmd.com/read/30263092/rapid-detection-of-copy-number-variations-and-point-mutations-in-brca1-2-genes-using-a-single-workflow-by-ion-semiconductor-sequencing-pipeline
#8
Aldo Germani, Fabio Libi, Stefano Maggi, Gianluca Stanzani, Augusto Lombardi, Patrizia Pellegrini, Mauro Mattei, Laura De Marchis, Claudio Amanti, Antonio Pizzuti, Maria Rosaria Torrisi, Maria Piane
Molecular analysis of BRCA1 ( MIM # 604370) and BRCA2 ( MIM #600185) genes is essential for familial breast and ovarian cancer prevention and treatment. An efficient, rapid, cost-effective accurate strategy for the detection of pathogenic variants is crucial. Mutations detection of BRCA1/2 genes includes screening for single nucleotide variants (SNVs), small insertions or deletions (indels), and Copy Number Variations (CNVs). Sanger sequencing is unable to identify CNVs and therefore Multiplex Ligation Probe amplification (MLPA) or Multiplex Amplicon Quantification (MAQ) is used to complete the BRCA1/2 genes analysis...
September 14, 2018: Oncotarget
https://www.readbyqxmd.com/read/30218983/skin-permeable-liposome-improved-stability-and-permeability-of-bfgf-against-skin-of-mice-with-deep-second-degree-scald-to-promote-hair-follicle-neogenesis-through-inhibition-of-scar-formation
#9
He-Lin Xu, Pian-Pian Chen, Li-Fen Wang, Meng-Qi Tong, Zi-Hui Ou, Ying-Zheng Zhao, Jian Xiao, Ting-Ling Fu, Wei-Xue
Excessive deposition of extracellular matrix (ECM) usually resulted in scar formation during wound healing, which caused skin dysfunction, such as hair loss. Basic fibroblast growth factor (bFGF) was very helpful for promoting hair follicle neogenesis and regulating the remodeling of ECM during wound healing. Because of its poor stability in wound fluids and low permeability against the dense wound scar, the repairing quality of bFGF on wound was hindered largely in clinical practice. To overcome these drawbacks, herein, a novel liposome with silk fibroin hydrogel core (bFGF-SF-LIP) was firstly prepared to stabilize bFGF, followed by insertion of laurocapam, a permeation enhancer, into the liposomal membrane to construct a skin-permeable liposome (SP-bFGF-SF-LIP)...
September 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30211866/assessing-patterns-for-compressive-fluorescence-lifetime-imaging
#10
M Ochoa, Q Pian, R Yao, N Ducros, X Intes
A novel hyperspectral single pixel system was used to compare different compressive basis patterns for intensity imaging, lifetime imaging, and FRET quantification. Six popular basis patterns were compared experimentally in a phantom containing two fluorescent dyes. The basis patterns that performed best for lifetime quantification were used to measure FRET occurrence in well-plate samples with varying acceptor-donor ratios. The ABS-WP approach using Haar patterns and the compressive sensing approach with Hadamard Ranked patterns displayed the best overall performances at a 50% compression ratio...
September 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/30195750/targeting-the-igf1r-pathway-in-breast-cancer-using-antisense-lncrna-mediated-promoter-cis-competition
#11
Lingling Pian, Xue Wen, Lihua Kang, Zhaozhi Li, Yuanyuan Nie, Zhonghua Du, Dehai Yu, Lei Zhou, Lin Jia, Naifei Chen, Dan Li, Songling Zhang, Wei Li, Andrew R Hoffman, Jingnan Sun, Jiuwei Cui, Ji-Fan Hu
Aberrant insulin-like growth factor I receptor (IGF1R) signaling pathway serves as a well-established target for cancer drug therapy. The intragenic antisense long noncoding RNA (lncRNA) IRAIN, a putative tumor suppressor, is downregulated in breast cancer cells, while IGF1R is overexpressed, leading to an abnormal IGF1R/IRAIN ratio that promotes tumor growth. To precisely target this pathway, we developed an "antisense lncRNA-mediated intragenic cis competition" (ALIC) approach to therapeutically correct the elevated IGF1R/IRAIN bias in breast cancer cells...
September 7, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30172679/acute-stroke-as-first-manifestation-of-cerebral-aspergillosis
#12
Carla Anciones, Alicia de Felipe, Asier de Albóniga-Chindurza, Fernado Acebrón, Hector Pián, Jaime Masjuán, Iñigo Corral
OBJECTIVES: To describe the neurological manifestations of invasive aspergillosis presenting with a focal neurological deficit compatible with an acute stroke. MATERIALS AND METHODS: Retrospective analysis of a clinical series of patients between 2011 and 2017 with invasive aspergillosis and neurological symptoms compatible with an acute brain stroke. Clinical and epidemiological data, microbiological results, radiological findings, treatment, and course were recorded...
August 29, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/30172195/association-between-prenatal-exposure-to-cooking-oil-fumes-and-full-term-low-birth-weight-is-mediated-by-placental-weight
#13
Pian Hu, Lijun Fan, Peng Ding, Yan-Hui He, Chuanbo Xie, Zhongzheng Niu, Fu-Ying Tian, Shixin Yuan, Deqin Jia, Wei-Qing Chen
OBJECTIVE: Evidence regarding the association between prenatal exposure to cooking oil fumes (COF) and full-term low birth weight (FTLBW) is still controversial, and the mechanism remains unclear. This study thus aims to explore the association of prenatal COF exposure with off-spring FT-LBW as well as the mediating role of placenta in their association. METHODS: A case-control study enrolling 266 pregnant women delivering FTLBW newborns (cases) and 1420 delivering normal birth weight (NBW) newborns (controls) was conducted...
November 2018: Environmental Research
https://www.readbyqxmd.com/read/30171347/comprehensive-assessment-of-the-association-between-genes-on-jak-stat-pathway-ifih1-tyk2-il-10-and-systemic-lupus-erythematosus-a-meta-analysis
#14
Qiong Yin, Liang-Cai Wu, Lu Zheng, Ming-Yu Han, Li-Ya Hu, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jiang-Wei Xia, Xiao-Bo Wang, Xing-Wei Zhang, Hou-Feng Zheng
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30111030/-anti-inflammatory-mechanism-of-dahuang-lidan-pian-by-network-pharmacology
#15
Xiao-Qian Huo, Yu Gu, Yan-Ling Zhang
Dahuang Lidan Pian contains Rheum palmatum, Gymnadenia conopsea and Phyllanthus emblica, which has a significant effect in the treatment of alcoholic fatty liver, cholestasis and cholecystitis. The efficacy of the formula in traditional Chinese medicine was clearing heat and promoting diuresis, removing dampness, detoxifying and relieving jaundice. These three herbs are widely used in the traditional Chinese medicine, Mongolian medicine and Tibetan medicine. Therefore, the formula was a representative subject in the researches for ethno-drugs...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30092249/hippo-yap-signaling-pathway-mitigates-blood-brain-barrier-disruption-after-cerebral-ischemia-reperfusion-injury
#16
Pian Gong, Zhan Zhang, Changlin Zou, Qi Tian, Xuemei Chen, Michael Hong, Xi Liu, Qianxue Chen, Zhou Xu, Mingchang Li, Jian Wang
Ischemia/reperfusion (I/R) injuries commonly lead to breakdown of the blood-brain barrier (BBB). Restoration of the BBB can relieve neurologic damage caused by I/R injuries. The Hippo/YAP signaling pathway mediates cell proliferation, regulated cell death, and differentiation in various organisms and has been shown to participate in the restoration of the heart after I/R. In this study, we investigated whether the Hippo/YAP pathway plays a role in I/R injury in brain, especially in regard to I/R-induced BBB breakdown...
January 1, 2019: Behavioural Brain Research
https://www.readbyqxmd.com/read/30030746/clinical-features-diagnosis-and-therapy-of-pituicytoma-an-update
#17
REVIEW
F J Salge-Arrieta, R Carrasco-Moro, V Rodríguez-Berrocal, H Pian, J S Martínez-San Millán, P Iglesias, L Ley-Urzáiz
BACKGROUND: Pituicytomas (PTs) are extremely rare, low-grade glial tumors closely related to the neurohypophyseal axis. Definite conclusions concerning the optimal diagnostic and therapeutic approach to these neoplasms are lacking to date, as most of this information has been presented as case reports. METHODS: Retrospective review of case reports published in the scientific literature to date, including a new illustrative example treated in our department. RESULTS: 116 cases were collected...
July 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30019299/rack1-deficiency-synergizes-with-all-trans-retinoic-acid-to-induce-apoptosis-in-human-acute-promyelocytic-leukemia-cells
#18
Huifang Wu, Jian Liu, Xiaofeng Huang, Lili Pian, Qianqian Cheng, Qingyang Wang, Min Zhao, Zhou Lin, Beifen Shen, Jiyan Zhang, Shulian Li, Jing Wang
As a classic differentiation agent, all-trans retinoic acid (ATRA) has been widely used in the treatment of acute promyelocytic leukemia (APL). However, the clinical application of ATRA has strict limitations, for its severe side effects due to the accumulation of peripheral blood leukocytes. The scaffold protein RACK1 (Receptor for activated C kinase 1), which regulates multiple signaling pathways, has been proposed to contribute to the survival of leukemic progenitors. But it remains unclear whether it is also involved in the oncogenic growth of APL...
July 17, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29981798/etiology-dependent-impairment-of-relaxation-kinetics-in-right-ventricular-end-stage-failing-human-myocardium
#19
Jae-Hoon Chung, Brit L Martin, Benjamin D Canan, Mohammad T Elnakish, Nima Milani-Nejad, Nancy S Saad, Steven J Repas, J Eric J Schultz, Jason D Murray, Jessica L Slabaugh, Rachel L Gearinger, Jennifer Conkle, Tallib Karaze, Neha Rastogi, Mei-Pian Chen, Will Crecelius, Kyra K Peczkowski, Mark T Ziolo, Vadim V Fedorov, Ahmet Kilic, Bryan A Whitson, Robert S D Higgins, Sakima A Smith, Peter J Mohler, Philip F Binkley, Paul M L Janssen
BACKGROUND: In patients with end-stage heart failure, the primary etiology often originates in the left ventricle, and eventually the contractile function of the right ventricle (RV) also becomes compromised. RV tissue-level deficits in contractile force and/or kinetics need quantification to understand involvement in ischemic and non-ischemic failing human myocardium. METHODS AND RESULTS: The human population suffering from heart failure is diverse, requiring many subjects to be studied in order to perform an adequately powered statistical analysis...
August 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29979439/recurrent-ovarian-hemorrhage-in-a-patient-with-aplastic-anemia-a-case-report
#20
Hua-Di Yang, Meng-Ting Xia, Yi-Feng Shao, Pian Ying
RATIONALE: Recurrent ovarian hemorrhage resulting in ovarian infarction may lead to a life-threatening intraperitoneal hemorrhage in women with bleeding disorders such as aplastic anemia (AA). Moreover, it is seen as ovarian tumors in the diagnosis. The authors report a clinical case with the aim of sharing our experiences and exploring the ways to diagnose, treat, and avoid ovarian hemorrhage. PATIENTS CONCERNS: A 48-year-old woman with AA had suffered from a serious abdominal distension for the past 24 hours, which had occurred intermittently for the past 15 years...
July 2018: Medicine (Baltimore)
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