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https://www.readbyqxmd.com/read/28032704/treatment-and-management-of-osteoporotic-fractures-a-nation-wide-survey-of-484-senior-orthopaedists-in-china
#1
Yi Man, Wei Pan, Jin Lu, Sen-Yuan Li, Pian Zhang, Jun-Zhe Guo, Shu-Fang Yu, Bei Zhang, En Xiao, Chao Zhang, Wei Zuo, He-Juan Jin, Yi Chen, Bin Wu, Xiao-En Shi, Di Hong, Xun Liu, Ying-Xu Gao, Jing Li, Lu Yin, Qing-Yun Xue
OBJECTIVE: To investigate the treatment given to osteoporotic fracture patients by orthopaedists at major hospitals in China. METHODS: A 25-item quantitative questionnaire survey, categorized into five domains, including primary purpose of osteoporosis treatment, anti-osteoporosis therapy, calcium and vitamin D supplement, monitoring of osteoporosis, and knowledge of osteoporosis treatment, was designed to elicit information on orthopaedists' views on the treatment of osteoporotic fracture...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28007548/enhanced-neuroprotection-with-decellularized-brain-extracellular-matrix-containing-bfgf-after-intracerebral-transplantation-in-parkinson-s-disease-rat-model
#2
Qian Lin, Ho Lun Wong, Fu-Rong Tian, Ya-Dong Huang, Jie Xu, Jing-Jing Yang, Pian-Pian Chen, Zi-Liang Fan, Cui-Tao Lu, Ying-Zheng Zhao
Extracellular matrix-based biomaterials have many advantages over synthetic polymer materials for regenerative medicine applications. In central nervous system (CNS), basic fibroblast growth factor (bFGF) is widely studied as a potential agent for Parkinson's disease (PD). However, the poor stability of bFGF hampered its clinical use. In this study, CNS-derived biologic scaffold containing bFGF was used to enhance and extend the neuroprotective effect of bFGF on PD targeted therapy. Decellularized brain extracellular matrix (dcBECM) was prepared by chemical extraction...
December 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27956614/molecular-profiling-of-single-circulating-tumor-cells-from-lung-cancer-patients
#3
Seung-Min Park, Dawson J Wong, Chin Chun Ooi, David M Kurtz, Ophir Vermesh, Amin Aalipour, Susie Suh, Kelsey L Pian, Jacob J Chabon, Sang Hun Lee, Mehran Jamali, Carmen Say, Justin N Carter, Luke P Lee, Ware G Kuschner, Erich J Schwartz, Joseph B Shrager, Joel W Neal, Heather A Wakelee, Maximilian Diehn, Viswam S Nair, Shan X Wang, Sanjiv S Gambhir
Circulating tumor cells (CTCs) are established cancer biomarkers for the "liquid biopsy" of tumors. Molecular analysis of single CTCs, which recapitulate primary and metastatic tumor biology, remains challenging because current platforms have limited throughput, are expensive, and are not easily translatable to the clinic. Here, we report a massively parallel, multigene-profiling nanoplatform to compartmentalize and analyze hundreds of single CTCs. After high-efficiency magnetic collection of CTC from blood, a single-cell nanowell array performs CTC mutation profiling using modular gene panels...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27923658/temporal-regulation-of-gap-junctional-communication-between-tenocytes-subjected-to-static-tensile-strain-with-physiological-and-non-physiological-amplitudes
#4
Eijiro Maeda, Haicheng Pian, Toshiro Ohashi
The present study has been performed on temporal changes in gap junctional intercellular communication (GJIC) between tenocytes under static tensile strain with the magnitude of 0% (no strain), 4% (physiological magnitude) or 8% (overloading magnitude) during a 24-h culture period. Tenocytes were isolated from rabbit Achilles tendon and seeded on a stretchable microgroove substrate. GJIC was evaluated as intercellular diffusion coefficient of calcein (DGJ) using fluorescence loss in photobleaching (FLIP) protocol accompanied with a mathematical model of molecular diffusion both within the cell and between the cells...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27922061/thermo-sensitive-hydrogels-combined-with-decellularised-matrix-deliver-bfgf-for-the-functional-recovery-of-rats-after-a-spinal-cord-injury
#5
He-Lin Xu, Fu-Rong Tian, Cui-Tao Lu, Jie Xu, Zi-Liang Fan, Jing-Jing Yang, Pian-Pian Chen, Ya-Dong Huang, Jian Xiao, Ying-Zheng Zhao
Because of the short half-life, either systemic or local administration of bFGF shows significant drawbacks to spinal injury. In this study, an acellular spinal cord scaffold (ASC) was encapsulated in a thermo-sensitive hydrogel to overcome these limitations. The ASC was firstly prepared from the spinal cord of healthy rats and characterized by scanning electronic microscopy and immunohistochemical staining. bFGF could specifically complex with the ASC scaffold via electrostatic or receptor-mediated interactions...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871447/novel-compound-heterozygous-mutations-in-a-child-with-ataxia-telangiectasia-showing-unrelated-cerebellar-disorders
#6
Maria Piane, Anna Molinaro, Annarosa Soresina, Silvia Costa, Marianna Maffeis, Aldo Germani, Lorenzo Pinelli, Roberta Meschini, Alessandro Plebani, Luciana Chessa, Roberto Micheli
We report the case of a 6-year-old female patient with Ataxia Telangiectasia, an extremely rare condition, who developed in addition a left cerebellar astrocytoma and a right cerebellar infarction, considered as two independent events. Children with AT have an increased risk of developing cancer, but only few cases of glioma are reported and, at our knowledge, no other case of unrelated cerebellar glioma and cerebellar infarction in with the same AT patient have been described. The molecular analysis of ATM (Ataxia Telangiectasia Mutated) gene showed that the patient is compound heterozygote for two previously unreported mutations: c...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27865929/g2-m-cell-cycle-arrest-on-ht-29-cancer-cells-and-toxicity-assessment-of-triphenylphosphanegold-i-carbonimidothioates-ph3pau-sc-or-nph-r-me-et-and-ipr-during-zebrafish-development
#7
Kah Kooi Ooi, Chien Ing Yeo, Theventhiran Mahandaran, Kok Pian Ang, Abdah Md Akim, Yoke-Kqueen Cheah, Hoi-Ling Seng, Edward R T Tiekink
Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NPh], R=Me (1), Et (2) and iPr (3), were previously shown to be significantly cytotoxic toward HT-29 cancer cells and to induce cell death by both intrinsic and extrinsic apoptotic pathways whereby 1 activated the p73 gene, and each of 2 and 3 activated p53; 2 also caused apoptotic cell death via the c-Jun N-terminal kinase/mitogen-activated protein kinase pathway. Apoptosis pathways have been further evaluated by mitochondrial cytochrome c measurements and annexin V screening, confirming apoptotic pathways of cell death...
January 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27861969/quality-of-life-of-patients-with-recurrent-respiratory-papillomatosis
#8
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy. STUDY DESIGN: Prospective cross-sectional questionnaire research. METHODS: Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27860312/cytochrome-p450-26a1-modulates-natural-killer-cells-in-mouse-early-pregnancy
#9
Chao-Yang Meng, Zhong-Yin Li, Wen-Ning Fang, Zhi-Hui Song, Dan-Dan Yang, Dan-Dan Li, Ying Yang, Jing-Pian Peng
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and protein levels during peri-implantation. Inhibiting the function or expression of CYP26A1 can cause pregnancy failure, suggesting an important regulatory role of CYP26A1 in the maintenance of pregnancy. However, little is known about the exact mechanism involved. In this study, using a pCR3.1-cyp26a1 plasmid immunization mouse model and a Cyp26a1-MO (Cyp26a1-specific antisense oligos) knockdown mouse model, we report that the number of Dolichos biflorus agglutinin (DBA) lectin-positive uterine natural killer (uNK) cells was reduced in pCR3...
November 17, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27771875/increased-default-mode-network-connectivity-and-increased-regional-homogeneity-in-migraineurs-without-aura
#10
Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qian Yao, Qiting Zhang, Haifeng Lu, Hui Zhang, Shuo Wang, Ge-Fei Li, Yi-Lan Wu, Feng-Di Liu, Yan-Hui Shi, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
BACKGROUND: The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate. METHODS: This study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27755775/spurious-reticulocyte-profiles-in-a-dog-with-babesiosis
#11
Laetitia Piane, Marie-Laure Théron, Marcel Aumann, Catherine Trumel
A 9-year-old, female Maltese dog was referred to the Veterinary School of Toulouse with a 2-day history of anorexia and weakness. On clinical examination, the dog had hyperthermia (39.7°C), abdominal discomfort, and polypnea. Significant laboratory findings included pigmenturia, hyperbilirubinemia, hypercreatininemia, hyperfibrinogenemia, abnormal Snap canine pancreas-specific lipase, and pancytopenia with a nonregenerative anemia. A peripheral blood smear revealed numerous intraerythrocytic large Babesia but no polychromasia...
December 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27743286/gastrodin-reduces-the-severity-of-status-epilepticus-in-the-rat-pilocarpine-model-of-temporal-lobe-epilepsy-by-inhibiting-nav1-6-sodium-currents
#12
Hui Shao, Yang Yang, Ai-Ping Qi, Pian Hong, Guang-Xi Zhu, Xin-Yu Cao, Wei-Gang Ji, Zhi-Ru Zhu
Temporal lobe epilepsy (TLE) is one of the most refractory types of adult epilepsy, and treatment options remain unsatisfactory. Gastrodin (GAS), a phenolic glucoside used in Chinese herbal medicine and derived from Gastrodia elata Blume, has been shown to have remarkable anticonvulsant effects on various models of epilepsy in vivo. However, the mechanisms of GAS as an anticonvulsant drug remain to be established. By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms...
October 14, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27734674/phenylamine-functionalized-rgo-tio2-photocatalysts-spatially-separated-adsorption-sites-and-tunable-photocatalytic-selectivity
#13
Huogen Yu, Pian Xiao, Jing Tian, Fazhou Wang, Jiaguo Yu
The preferential adsorption of targeted contaminants on a photocatalyst surface is highly required to realize its photocatalytic selective decomposition in a complex system. To realize the tunable preferential adsorption, altering the surface charge or polarity property of photocatalysts has widely been reported. However, it is quite difficult for a modified photocatalyst to realize the simultaneously preferential adsorption for both cationic and anionic dyes. In this study, to realize the selective adsorption for both cationic and anionic dyes on a photocatalyst surface, the negative reduced graphene oxide (rGO) nanosheets and positive phenylamine (PhNH2) molecules are successfully loaded on the TiO2 surface (PhNH2/rGO-TiO2) with spatially separated adsorption sites, where the negative rGO and positive PhNH2 molecules work as the preferential adsorption sites for cationic and anionic dyes, respectively...
October 13, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27701759/spurious-reticulocyte-profiles-in-dogs-with-large-form-babesiosis-a-retrospective-study
#14
Laetitia Piane, Karen M Young, Lena Giraud, Nathalie Bourges-Abella, Catherine Trumel
BACKGROUND: Erroneously high reticulocyte counts (pseudoreticulocytosis) have been reported in dogs with leukemia. Pseudoreticulocytosis and an abnormal reticulocyte profile were observed in a dog with large form babesiosis presented at our institution. OBJECTIVES: The aims of this retrospective study were to determine if dogs with babesiosis and other dogs had abnormal reticulocyte profiles, and to correlate these profiles with the primary diagnosis. METHODS: All canine CBCs obtained with the Sysmex XT-2000iV or Procyte DX were reviewed...
December 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27639383/addition-of-the-p110%C3%AE-inhibitor-byl719-overcomes-targeted-therapy-resistance-in-cells-from-her2-positive-pten-loss-breast-cancer
#15
Chen Zhang, Bingfei Xu, Pian Liu
Breast cancer is one of the leading causes of death for women worldwide. Among various subtypes of breast cancer, human epidermal growth factor receptor 2 (HER2)-positive and phosphatase and tensin homolog (PTEN) loss breast cancer is a cause of great concern in terms of its resistance to HER2-targeted therapies and its poor prognosis. Phosphatidylinositol 3-kinase (PI3K)/AKT hyperphosphorylation is considered one of key mechanisms leading to this resistance, thus combination therapy of PI3K inhibitors and HER2 antibodies is promising for overcoming this problem, and more specific regimens should be designed in this age of precision medicine...
November 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27614158/an-injectable-acellular-matrix-scaffold-with-absorbable-permeable-nanoparticles-improves-the-therapeutic-effects-of-docetaxel-on-glioblastoma
#16
He-Lin Xu, Kai-Li Mao, Cui-Tao Lu, Zi-Liang Fan, Jing-Jing Yang, Jie Xu, Pian-Pian Chen, De-Li ZhuGe, Bi-Xin Shen, Bing-Hui Jin, Jian Xiao, Ying-Zheng Zhao
Intratumoral drug delivery (IT) is an inherently appealing approach for concentrating toxic chemotherapies at the site of action. However, for most chemotherapies, poor tumor penetration and short retention at the administration site limit their anti-tumor effects. In this work, we describe permeable nanoparticles (NPs) prepared with a novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL). The nanoparticles (NPs) of VES-g-ε-PLL exhibited an ultra-small hydrodynamic diameter (20...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27600632/validation-of-the-distress-thermometer-and-problem-list-in-patients-with-recurrent-respiratory-papillomatosis
#17
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
Objective There is no specific clinical tool for physicians to detect psychosocial and physical distress or health care need in patients with recurrent respiratory papillomatosis (RRP). The main aim of this study is to validate the RRP-adapted Distress Thermometer and Problem List (DT&PL). Study Design Prospective cross-sectional questionnaire research. Setting Academic tertiary care medical centers in Groningen, Netherlands, and Helsinki, Finland. Subjects and Methods Ninety-one juvenile- and adult-onset RRP patients participated from the departments of otorhinolaryngology-head and neck surgery of the University Medical Center Groningen, Netherlands, and Helsinki University Hospital, Finland...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27557920/utilization-of-chinese-herbal-medicine-for-selected-oral-conditions-in-two-pediatric-populations
#18
Minyue R Dai, Daniel K Ho, Lihua Huang, Ryan L Quock, Catherine M Flaitz
PURPOSE: To characterize traditional Chinese medicine (TCM) use, emphasizing herbal remedies, for oral conditions among two Chinese pediatric populations in the United States. METHODS: 318 unique ethnic Chinese parental units in Houston and Boston with children younger than 12 years old were interviewed for themselves and their children. Questionnaire included age, gender, duration in the United States, frequency of TCM use, and the five selected oral conditions for which TCM agents might be used...
2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27538381/comprehensive-assessment-of-the-association-between-fcgrs-polymorphisms-and-the-risk-of-systemic-lupus-erythematosus-evidence-from-a-meta-analysis
#19
Xiao-Wei Zhu, Yong Wang, Yi-Hua Wei, Pian-Pian Zhao, Xiao-Bo Wang, Jing-Jing Rong, Wen-Ying Zhong, Xing-Wei Zhang, Li Wang, Hou-Feng Zheng
We performed a meta analysis to assess the relationship of FCGRs polymorphisms with the risk of SLE. Thirty-five articles (including up to 5741 cases and 6530 controls) were recruited for meta-analysis. The strongest association was observed between FCGR2B rs1050501 and SLE under the recessive genotypic model of C allele in the overall population (CC vs CT/TT, OR = 1.754, 95%CI: 1.422-2.165, P = 1.61 × 10(-7)) and in Asian population (CC vs CT/TT, OR = 1.784, 95%CI; 1.408-2.261, P = 1.67 × 10(-6))...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27479259/-emergence-delirium-in-children-prophylaxis-and-treatment
#20
Julius Z Wermelt, Richard K Ellerkmann
Emergence Delirium in children after general anesthesia is a common and self limitating event. Although it might be seen as being harmless it can cause other serious complications and might leave both parents and other caregivers with a negative impression behind. Although the cause may still not be clear, potential predictors can be named: preschool age, the use of fast acting volatile anesthestics, higher preoperative anxiety levels and postoperative pain.A child-focused approach to reduce preoperative anxiety focusing on distraction methods rather than pharmacological sedation may be the key as well as sufficient postoperative pain control and the use of total intravenous anesthesia...
July 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
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