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Jae-Hoon Chung, Brit L Martin, Benjamin D Canan, Mohammad T Elnakish, Nima Milani-Nejad, Nancy S Saad, Steven J Repas, J Eric J Schultz, Jason D Murray, Jessica L Slabaugh, Rachel L Gearinger, Jennifer Conkle, Tallib Karaze, Neha Rastogi, Mei-Pian Chen, Will Crecelius, Kyra K Peczkowski, Mark T Ziolo, Vadim V Fedorov, Ahmet Kilic, Bryan A Whitson, Robert S D Higgins, Sakima A Smith, Peter J Mohler, Philip F Binkley, Paul M L Janssen
BACKGROUND: In patients with end-stage heart failure, the primary etiology often originates in the left ventricle, and eventually the contractile function of the right ventricle (RV) also becomes compromised. RV tissue-level deficits in contractile force and/or kinetics need quantification to understand involvement in ischemic and non-ischemic failing human myocardium. METHODS AND RESULTS: The human population suffering from heart failure is diverse, requiring many subjects to be studied in order to perform an adequately powered statistical analysis...
July 5, 2018: Journal of Molecular and Cellular Cardiology
Hua-Di Yang, Meng-Ting Xia, Yi-Feng Shao, Pian Ying
RATIONALE: Recurrent ovarian hemorrhage resulting in ovarian infarction may lead to a life-threatening intraperitoneal hemorrhage in women with bleeding disorders such as aplastic anemia (AA). Moreover, it is seen as ovarian tumors in the diagnosis. The authors report a clinical case with the aim of sharing our experiences and exploring the ways to diagnose, treat, and avoid ovarian hemorrhage. PATIENTS CONCERNS: A 48-year-old woman with AA had suffered from a serious abdominal distension for the past 24 hours, which had occurred intermittently for the past 15 years...
July 2018: Medicine (Baltimore)
Feng Qiu, Han Liu, Huan Duan, Pian Chen, Shao-Juan Lu, Guang-Zhong Yang, Xin-Xiang Lei
Schisandra chinensis (Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system. With considerable chemical investigation, three new triterpenoids ( 1 ⁻ 3 ), together with four known triterpenoids were isolated from the S. chinensis (Turcz) Baill. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses, single-crystal X-ray diffraction and high-resolution mass spectroscopy, which were identified as Schisanlactone I ( 1 ), Schinalactone D, ( 2 ), Schisanlactone J, ( 3 ) Kadsuphilactone B ( 4 ), Schisanlactone C ( 5 ), Schisphendilactone B ( 6 ), and Schinchinenlactone A ( 7 )...
July 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cong Pian, Guangle Zhang, Tengfei Tu, Xiangyu Ma, Fei Li
Long non-coding RNAs (lncRNAs) are endogenous molecules longer than 200 nucleotides, and lack coding potential. LncRNAs that interact with microRNAs (miRNAs) are known as a competing endogenous RNAs (ceRNAs) and have the ability to regulate the expression of target genes. The ceRNAs play an important role in the initiation and progression of various cancers. However, until now, there is no a database including a collection of experimentally verified, human ceRNAs. We developed the LncCeRBase database, which encompasses 432 lncRNA-miRNA-mRNA interactions, including 130 lncRNAs, 214 miRNAs and 245 genes from 300 publications...
January 1, 2018: Database: the Journal of Biological Databases and Curation
Xiaobo Pang, Ke Zhang, Jian Huang, Hangyu Wang, Le Gao, Tao Wang, Yingnan Sun, Long Chen, Jinhui Wang
Bai Xuan Xia Ta Re Pian (BXXTR) is a traditional Uighur medicine ancient prescription in China widely used in the treatment of psoriasis, presenting a high curative rate and few side effects. Given that the active constituents and action mechanism still remain unclear, the aim of this study is to explore the potential active constituents and mechanism of antipsoriasis of BXXTR. Psoriasis-like lesions model in BALB/c mice was induced by Imiquimod (IMQ), including five treatment groups: control group, IMQ-treated group, IMQ-ACITRETIN group (Positive control group), IMQ-BXXTR low dose group, IMQ-BXXTR medium dose group and IMQ-BXXTR high dose group...
June 21, 2018: International Journal of Molecular Sciences
J R Son, Y Liu, Q N Ma, B Z Ju, K F Sun, J D Wu, L D Zhang, G L Yang
In the Huang di nei jing ( Huangdi ' s Internal Classic ), jin ye (fluid and humor) is described in two senses, broad and narrow, though not so strictly.Sometimes, jin ye is explained ambiguously as "sweat" and "urine" , as in the phrase "the bladder, being a house of jin ye " , here " jin ye " refers to the urine. In the Qi jue lun pian of Su wen ( Chapter on Qi - Syncope of Plain Questions ) , the " bao " in the sentence "heat of bao moved to bladder" refersto the uterus...
September 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
Bowen Sun, Geng Wang, Huidong Liu, Pian Liu, Waleed O Twal, Hiuwing Cheung, Steven L Carroll, Stephen P Ethier, Emily E Mevers, Jon Clardy, Thomas Roberts, Changbin Chen, Qian Li, Lanfeng Wang, Meixiang Yang, Jean J Zhao, Qi Wang
Aberrant activation of phosphatidylinosito-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) signaling in cancer has led to pursuit of inhibitors for targeting this pathway. However, inhibitors of PI3K and AKT have failed to yield efficacious results without adverse effects. Here, we screened a library containing 441 authenticated traditional chinese medicine (TCM) plant extracts by examining their effect on cell viability of a human mammary epithelial cell line HMEC-PIK3CAH1047R , which expresses mutant PIK3CAH1047R and has constitutively active AKT signaling...
May 8, 2018: Oncotarget
Nicola Mongera, Vittorio Di Maso, Elisabetta Ermacora, Michele Carraro, Cristina Bregant, Martina Pian, Umberto Savi, Eric Lorenzon, Giuliano Boscutti
Granulomatosis polyangiitis (GPA) is an ANCA-related vasculitis (AAV) whose clinical manifestations mainly concern the respiratory tract (upper and lower) and the kidney. The treatment of GPA (as well as other AAV) includes the use of immunosuppressive drugs with numerous side effects; the most frequent complications are infectious and neoplastic. GPA frequently relapses. Epstein Barr Virus (EBV) is a ubiquitous virus; it is estimated that about 90% of the world’s population has BEEN EXPOSED TO with this pathogen and has subsequently developed a latent infection...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Weiliang Liu, Jingli Yan, Zhenhao Zhang, Hongru Pian, Chenghui Liu, Zhengping Li
N 6 -Methyladenosine (m6 A) is the most frequent post-transcriptional modification in RNA, and it plays a critical role in biological processes. The functions of m6 A remain largely unexplored due to a lack of highly sensitive methods to quantitatively determine the m6 A modification fraction at a precise location. Here, we first reveal that T3 DNA ligase has significant selectivity towards the m6 A modification. On the basis of the new finding, we establish an ultrasensitive quantitation assay for accurately determining m6 A at one-nucleotide resolution in RNA...
April 7, 2018: Chemical Science
Na Bao, Jinfeng Ou, Na Li, Pian Zou, Jianbo Sun, Li Chen
High levels of both nitric oxide (NO) and reactive oxygen species (ROS) could act as pro-apoptotic signals in cancerous cells. In this study, we conjugated diazeniumdiolates (NONOates), an important class of NO donors, with a natural occurring plumbagin (PL) which is primarily an excellent ROS inducer. Herein, a total of 12 novel plumbagin/NONOate hybrids have been synthesized and evaluated for their inhibitory effects on a panel of human cancer cell lines (MDA-MB-231, A549, HepG2 and HCT-116 cells) and two normal human cells (HK-2 and WRL-68 cells)...
June 25, 2018: European Journal of Medicinal Chemistry
Guangle Zhang, Cong Pian, Zhi Chen, Jin Zhang, Mingmin Xu, Liangyun Zhang, Yuanyuan Chen
LncRNAs are regulatory noncoding RNAs that play crucial roles in many biological processes. The dysregulation of lncRNA is thought to be involved in many complex diseases; lncRNAs are often the targets of miRNAs in the indirect regulation of gene expression. Numerous studies have indicated that miRNA-lncRNA interactions are closely related to the occurrence and development of cancers. Thus, it is important to develop an effective method for the identification of cancer-related miRNA-lncRNA interactions. In this study, we compiled 155653 experimentally validated and predicted miRNA-lncRNA associations, which we defined as basic interactions...
2018: PloS One
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
Eugenia Sánchez Rodríguez, Raquel Ríos León, Álvaro Flores de Miguel, Antonio Guerrero García, Héctor Pian, Francisco Gea Rodríguez, Agustín Albillos Martínez
No abstract text is available yet for this article.
April 9, 2018: Gastroenterología y Hepatología
Francesco Licciardi, Giacomo Scaioli, Roberta Mulatero, Agostina Marolda, Marta Delle Piane, Silvana Martino, Davide Montin, Pier Angelo Tovo
OBJECTIVES: To estimate the incidence of acute rheumatic fever (ARF) in a metropolitan area of Northern Italy and study how the introduction of the 2015 revised Jones criteria affects the epidemiology in a region with moderate to high incidence of ARF. STUDY DESIGN: The incidence of ARF in children 5-14 years old living in the Province of Turin was estimated using low-risk criteria in a 10-year period (group A patients). The proportion of patients fulfilling only high-risk (HR) criteria (group B patients) was also calculated both prospectively (from July 2015 through December 2016) and retrospectively (from January 2007 through June 2015)...
March 28, 2018: Journal of Pediatrics
Xue Feng, Sai-Nan Fang, Yu-Xin Gao, Jian-Ping Liu, Wei Chen
To provide the basis for the future research on the nephrotoxicity of Chinese herbal medicine through systematic and comprehensive summary of all the Chinese herbal medicines which may lead to nephrotoxicity. Foreign resources included PubMed and Cochrane library, and domestic research resources was China Food and Drug Administration(CDFA) Adverse Drug Reaction Monitoring Center database. The databases were searched from establishment to January 1, 2017. There was no limitation on research type. 28 English studies were found, including 97 Chinese herbs or prescriptions with the risk of nephrotoxicity...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Pian-Pian Chen, He-Lin Xu, Ting-Yue, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Li-Fen Wang, Cui-Tao Lu, Ying-Zheng Zhao, Xiao-Kun Li
Nephropathy is one of the most severe complications of diabetic patients. The therapeutic strategies for diabetic patients should not only focus on the control of blood glucose but also pay attention to the occurrence of diabetic nephropathy (DN). Coenzyme Q10 (CoQ10) has great therapeutic potential for DN. However, the clinical application of CoQ10 has been limited because of its low water-solubility and non-specific distribution. Liposomes were supposed to be an effective way for delivering CoQ10 to kidney...
February 20, 2018: Oncotarget
Xiao-Xue Lv, Yu-Lin Wang
Origin of Chinese Characters (Shuowen Jiezi) records a large number of drug names, providing rich materials for the study of the history of pharmacy. But in the aftertime circulating process, errors were inevitable, making the ancient scholars disagree on the relationship between some drug names and their referents. This paper would give a textual research on medication names about chu, huo, huo, and hua. Relevant content was analyzed by using Shuowen Jiezi, Er Ya,Yu Pian and previous annotations of these exegesis books, as well as herbal literature...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Pian Wu, Ruixue Huang, Guiyin Li, Yayuan He, Cuimei Chen, Wen Xiao, Ping Ding
This study prepared an innovative 3-mercaptopropionic acid modified ZnSe/ZnS core/shell quantum dots (MPA-ZnSe/ZnS QDs), and established a rapid fluorescence method to detect the E. coli cells count by using MPA-ZnSe/ZnS QDs as fluorescence probe. The formulation variables and process were optimized using the response surface methodology (RSM). Fluorescence microscopy was used to obtain fluorescence microscope images of MPA-ZnSe/ZnS QDs that bind to bacteria. The fluorescence peak intensity increases with increasing cells count in the range of 101-108 CFU/mL...
May 1, 2018: Journal of Nanoscience and Nanotechnology
He-Lin Xu, Fu-Rong Tian, Jian Xiao, Pian-Pian Chen, Jie Xu, Zi-Liang Fan, Jing-Jing Yang, Cui-Tao Lu, Ying-Zheng Zhao
Introduction: The short lifetime of protein-based therapies has largely limited their therapeutic efficacy in injured nervous post-spinal cord injury (post-SCI). Methods: In this study, an affinity-based hydrogel delivery system provided sustained-release of proteins, thereby extending the efficacy of such therapies. The affinity-based hydrogel was constructed using a novel polymer, heparin-poloxamer (HP), as a temperature-sensitive bulk matrix and decellular spinal cord extracellular matrix (dscECM) as an affinity depot of drug...
2018: International Journal of Nanomedicine
He-Lin Xu, De-Li ZhuGe, Pian-Pian Chen, Meng-Qi Tong, Meng-Ting Lin, Xue Jiang, Ya-Wen Zheng, Bin Chen, Xiao-Kun Li, Ying-Zheng Zhao
Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform (ICG-SFNPs) for photo-thermal therapy of glioblastoma. ICG was easily encapsulated into SFNPs with a very high encapsulation efficiency reaching to 97.7 ± 1.1%. ICG-SFNPs exhibited a spherical morphology with a mean particle size of 209...
November 2018: Drug Delivery
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