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https://www.readbyqxmd.com/read/27909722/expression-of-soluble-programmed-death-1-protein-in-peripheral-blood-regulatory-t-cells-and-its-effects-on-rheumatoid-arthritis-progression
#1
Chun-Feng Ren, Ya-Xin Zhao, Chun-Feng Hou, Luan Luan, Guo-Qing Duan, Shu-Jie Li, Jian-Hong Zhao
The present study aimed to investigate the role of the soluble programmed death‑1 (sPD-1) protein, which is released by peripheral blood regulatory T cells (Treg) during the progression of rheumatoid arthritis (RA). From October 2012 to May 2014, 82 RA patients (RA group) and 90 healthy volunteers (healthy controls; HC) were recruited. Cluster of differentiation (CD)4, CD25 and forkhead/winged helix transcription factor p3 (Foxp3) and expression of cytotoxic T lymphocyte associated antigen 4 (CTLA-4) and Foxp3 were detected by flow cytometry...
November 28, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27901519/predictors-of-comorbid-obsessive-compulsive-disorder-and-skin-picking-disorder-in-trichotillomania
#2
Nancy J Keuthen, Erin E Curley, Jeremiah M Scharf, Douglas W Woods, Christine Lochner, Dan J Stein, Esther S Tung, Erica Greenberg, S Evelyn Stewart, Sarah A Redden, Jon E Grant
BACKGROUND: Trichotillomania (TTM), obsessive-compulsive disorder (OCD), and skin-picking disorder (SPD) frequently occur together and share overlapping phenomenology, pathophysiology, and possible genetic underpinnings. This study sought to identify factors that predict OCD and SPD in hair pullers. METHODS: Five hundred fifty-five adult female hair pullers were recruited from specialty clinics and assessed using standardized, semi-structured interviews and self-reports...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27890817/sec-butylpropylacetamide-spd-a-new-amide-derivative-of-valproic-acid-for-the-treatment-of-neuropathic-and-inflammatory-pain
#3
Dan Kaufmann, Peter J West, Misty D Smith, Boris Yagen, Meir Bialer, Marshall Devor, H Steve White, K C Brennan
Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population. sec-Butylpropylacetamide (SPD) is a novel amide analogue of valproic acid (VPA) previously shown to possess a broad spectrum of anticonvulsant activity. In this study we defined the pharmacokinetic parameters of SPD in rat and mouse, and then evaluated its antinociceptive potential in neuropathic and acute inflammatory pain models. In the sciatic nerve ligation (SNL) model of neuropathic pain, SPD was equipotent to gabapentin and more potent than its parent compound VPA...
November 24, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27890695/nitric-oxide-polyamines-cross-talk-during-dormancy-release-and-germination-of-apple-embryos
#4
Urszula Krasuska, Katarzyna Ciacka, Agnieszka Gniazdowska
Nitric oxide (NO) and polyamines (PAs) belong to plant growth and development regulators. These compounds play a key role in numerous physiological processes e.g. seed germination. Based on the suggestion of overlapping of NO and PAs biosynthetic pathways, we demonstrated a cross-talk of NO and PAs in regulation of embryonic dormancy release. The aim of the work was to investigate an impact of PAs (Put, Spd and Spm) or NO short-term fumigation on nitrite, urea, Arg and ornithine (Orn) content, NO synthase-like (NOS-like) and arginase activity in axes of apple (Malus domestica Borkh...
November 23, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27877863/microstructure-study-of-a-severely-plastically-deformed-mg-zn-y-alloy-by-application-of-low-angle-annular-dark-field-diffraction-contrast-imaging
#5
Dudekula Althaf Basha, Julian M Rosalie, Hidetoshi Somekawa, Takashi Miyawaki, Alok Singh, Koichi Tsuchiya
Microstructural investigation of extremely strained samples, such as severely plastically deformed (SPD) materials, by using conventional transmission electron microscopy techniques is very challenging due to strong image contrast resulting from the high defect density. In this study, low angle annular dark field (LAADF) imaging mode of scanning transmission electron microscope (STEM) has been applied to study the microstructure of a Mg-3Zn-0.5Y (at%) alloy processed by high pressure torsion (HPT). LAADF imaging advantages for observation of twinning, grain fragmentation, nucleation of recrystallized grains and precipitation on second phase particles in the alloy processed by HPT are highlighted...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27873291/prediction-of-non-recovery-from-ventilator-demanding-acute-respiratory-failure-ards-and-death-using-lung-damage-biomarkers-data-from-a-1200-patient-critical-care-randomized-trial
#6
Jens-Ulrik S Jensen, Theis S Itenov, Katrin M Thormar, Lars Hein, Thomas T Mohr, Mads H Andersen, Jesper Løken, Hamid Tousi, Bettina Lundgren, Hans Christian Boesen, Maria E Johansen, Sisse R Ostrowski, Pär I Johansson, Jesper Grarup, Jørgen Vestbo, Jens D Lundgren
BACKGROUND: It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated with one-month clinical respiratory prognosis. If patients who do not recover respiratory function within one month can be identified early, future experimental lung interventions can be aimed toward this high-risk group. We aimed to determine, in a heterogenous critically ill population, whether baseline profound alveolar damage or conductive airway damage has clinical respiratory impact one month after intensive care admittance...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27872979/evaluation-of-isolated-urinary-stress-incontinence-according-to-the-type-of-levator-ani-muscle-lesion-using-3-4d-transperineal-ultrasound-36%C3%A2-months-post-partum
#7
José Antonio García Mejido, Pamela Valdivieso Mejias, Ana Fernández Palacín, María José Bonomi Barby, Paloma De la Fuente Vaquero, José Antonio Sainz Bueno
INTRODUCTION: Vaginal delivery can lead to pelvic floor disorders. Many authors have described pelvic floor injuries that can predict future defects such as urinary incontinence and pelvic organ prolapse. We propose the assessment of urinary stress incontinence and its association with levator ani muscle (LAM) microtrauma (>20% in the levator hiatus area during Valsalva) and macrotraumas (avulsion) identified by 3/4D transperineal ultrasound (3D-TpUS) 36 months post-partum. MATERIALS AND METHODS: This was a prospective observational study including 168 nulliparous women...
November 21, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27864994/serum-spd-l1-upregulated-in-sepsis-may-reflect-disease-severity-and-clinical-outcomes-in-septic-patients
#8
Minlong Liu, Xiaoling Zhang, Haiyan Chen, Guoen Wang, Jun Zhang, Peng Dong, Yuanyuan Liu, Shan An, Li Wang
we aimed to find the correlation between serum sPD-L1 (soluble programmed cell death L-1 ligand) and sepsis. Totally 91 consecutive patients with sepsis were performed in a 15-bed medical intensive care unit (ICU) of the second affiliated hospital, Xi'an Jiaotong University in Xi'an, China, between February 2015 and May 2016. Healthy controls (HC) consisted of 29 healthy volunteer. Baseline demographic data were recorded. Blood samples were collected through an indwelling central venous or by peripheral venipuncture...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27859153/integrating-population-dynamics-models-and-distance-sampling-data-a-spatial-hierarchical-state-space-approach
#9
Khurram Nadeem, Jeffrey E Moore, Ying Zhang, Hugh Chipman
Stochastic versions of Gompertz, Ricker, and various other dynamics models play a fundamental role in quantifying strength of density dependence and studying long-term dynamics of wildlife populations. These models are frequently estimated using time series of abundance estimates that are inevitably subject to observation error and missing data. This issue can be addressed with a state-space modeling framework that jointly estimates the observed data model and the underlying stochastic population dynamics (SPD) model...
July 2016: Ecology
https://www.readbyqxmd.com/read/27835962/soluble-programmed-cell-death-receptor-1-spd-1-a-potential-biomarker-with-anti-inflammatory-properties-in-human-and-experimental-acute-respiratory-distress-syndrome-ards
#10
Sean F Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G Fairbrother, Daithi S Heffernan, William G Cioffi, Alfred Ayala
BACKGROUND: Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding are not complete, and we lack biomarkers. DESIGN, SETTING, AND SUBJECTS: Blood and bronchial alveolar lavage fluid (BAL) from humans (n = 10-13) with ARDS and controls (n = 5-10) as well as a murine model of ARDS (n = 5-6) with controls (n = 6-7) were studied...
November 11, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27819117/polyamines-induced-aluminum-tolerance-in-mung-bean-a-study-on-antioxidant-defense-and-methylglyoxal-detoxification-systems
#11
Kamrun Nahar, Mirza Hasanuzzaman, Toshisada Suzuki, Masayuki Fujita
We investigated the roles of exogenously applied Spd (0.3 mM spermidine) in alleviating Al (AlCl3, 0.5 mM, 48 and 72 h)- induced injury in mung bean seedlings (Vigna radiata L. cv. BARI Mung-2). Aluminum toxicity induced oxidative damage overproducing reactive oxygen species (ROS; H2O2 and O2(•-)), increasing lipoxygenase activity and membrane lipid peroxidation. The toxic compound methylglyoxal (MG) also overproduced under Al stress. In order to circumvent Al-induced oxidative stress, enzymatic and non-enzymatic antioxidant defense were activated by the application of exogenous Spd...
November 7, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27809964/nanophyetus-salmincola-vector-of-the-salmon-poisoning-disease-agent-neorickettsia-helminthoeca-harbors-a-second-pathogenic-neorickettsia-species
#12
Stephen E Greiman, Michael L Kent, John Betts, Deborah Cochell, Tiah Sigler, Vasyl V Tkach
The trematode Nanophyetus salmincola is known as the carrier of Neorickettsia helminthoeca, an obligate intracellular endosymbiotic bacterium that causes salmon poisoning disease (SPD), a fatal disease of dogs. The bacteria are maintained through the complex life cycle of N. salmincola that involves snails Juga plicifera as the first intermediate host, salmonid fishes as the second intermediate host and fish-eating mammals as definitive hosts. N. salmincola was also found to harbor a second species of Neorickettsia that causes the Elokomin fluke fever disease (EFF) which has clinical signs similar to SPD in bears, but only low grade illness in dogs...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27807277/the-risk-of-stroke-in-spouses-of-people-living-with-dementia-in-korea
#13
Ickpyo Hong, Areum Han, Timothy A Reistetter, Annie N Simpson
BACKGROUND AND PURPOSE: As the Korean population ages, the number of patients with dementia is expected to increase. Although prior studies have reported that the burdens associated with caregiving impact the health of spouses of individuals with dementia, it is unclear whether those spouses have increased risk of stroke. We examined the relationship between the risks of stroke among spouses of people with dementia (SPD). METHODS: We retrieved a total of 314,526 respondents from the population-based surveys of the 2012 and 2013 Korea Community Health Survey...
November 2, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27806121/fully-automated-enhanced-tumor-compartmentalization-man-vs-machine-reloaded
#14
Nicole Porz, Simon Habegger, Raphael Meier, Rajeev Verma, Astrid Jilch, Jens Fichtner, Urspeter Knecht, Christian Radina, Philippe Schucht, Jürgen Beck, Andreas Raabe, Johannes Slotboom, Mauricio Reyes, Roland Wiest
OBJECTIVE: Comparison of a fully-automated segmentation method that uses compartmental volume information to a semi-automatic user-guided and FDA-approved segmentation technique. METHODS: Nineteen patients with a recently diagnosed and histologically confirmed glioblastoma (GBM) were included and MR images were acquired with a 1.5 T MR scanner. Manual segmentation for volumetric analyses was performed using the open source software 3D Slicer version 4.2.2.3 (www...
2016: PloS One
https://www.readbyqxmd.com/read/27789183/expression-of-ndufa13-in-asthenozoospermia-and-possible-pathogenesis
#15
Yang Yang, Laiyang Cheng, Ying Wang, Yilong Han, Jin Liu, Xiaohui Deng, Lan Chao
Asthenozoospermia is a common cause of male infertility, which is characterized by reduced forward motility of spermatozoa. The cause and pathogenesis of asthenozoospermia are not fully understood. The purpose of this study was to investigate the expression of nicotinamide adenine dinucleotide (NADH) dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (NDUFA13) in the spermatozoa of men with asthenozoospermia and its possible pathogenesis. Protein content of NDUFA13 in spermatozoa was measured by Western blot analysis...
October 14, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27783409/malondialdehyde-acetaldehyde-adducted-surfactant-protein-alters-macrophage-functions-through-scavenger-receptor-a
#16
Muna Sapkota, Kusum K Kharbanda, Todd A Wyatt
BACKGROUND: Reactive aldehydes such as acetaldehyde and malondialdehyde generated as a result of alcohol metabolism and cigarette smoke exposure lead to the formation of malondialdehyde-acetaldehyde-adducted proteins (MAA adducts). These aldehydes can adduct to different proteins such as bovine serum albumin and surfactant protein A or surfactant protein D (SPD). Macrophages play an important role in innate immunity, but the effect of MAA adducts on macrophage function has not yet been examined...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27780739/oligomeric-%C3%AE-synuclein-and-glucocerebrosidase-activity-levels-in-gba-associated-parkinson-s-disease
#17
S Pchelina, A Emelyanov, G Baydakova, P Andoskin, K Senkevich, M Nikolaev, I Miliukhina, A Yakimovskii, A Timofeeva, E Fedotova, N Abramycheva, T Usenko, D Kulabukhova, A Lavrinova, A Kopytova, L Garaeva, E Nuzhnyi, S Illarioshkin, E Zakharova
Alpha-synuclein oligomerization plays a key role in the development of Parkinson's disease (PD). Being the most common genetic contributor to PD, glucocerebrosidase 1 (GBA) mutations have been associated with decreased GBA enzymatic activity in PD patients with mutations in the GBA gene (GBA-PD). However, it is unknown whether the activities of other lysosomal hydrolases are being altered in GBA-PD patients and are accompanied by an increase in alpha-synuclein oligomerization. The aim of our study was to estimate GBA enzymatic activity as well as the activities of five other lysosomal hydrolases (galactocerebrosidase, alpha-glucosidase, alpha-galactosidase, sphingomyelinase, alpha-iduronidase) in dried blood spots with assessing plasma oligomeric alpha-synuclein levels in sporadic PD (sPD) patients, in GBA-PD patients and in controls...
October 22, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27770259/new-insights-from-an-old-mutant-spadix4-governs-fruiting-body-development-but-not-hyphal-fusion-in-sordaria-macrospora
#18
Ines Teichert, Miriam Lutomski, Ramona Märker, Minou Nowrousian, Ulrich Kück
During the sexual life cycle of filamentous fungi, multicellular fruiting bodies are generated for the dispersal of spores. The filamentous ascomycete Sordaria macrospora has a long history as a model system for studying fruiting body formation, and two collections of sterile mutants have been generated. However, for most of these mutants, the underlying genetic defect remains unknown. Here, we investigated the mutant spadix (spd) that was generated by X-ray mutagenesis in the 1950s and terminates sexual development after the formation of pre-fruiting bodies (protoperithecia)...
October 21, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27756251/analysis-of-the-kinetics-of-the-parathyroid-hormone-and-of-associated-patient-outcomes-in-a-cohort-of-haemodialysis-patients
#19
Guillaume Jean, Jean-Claude Souberbielle, Eric Zaoui, Christie Lorriaux, Jean-Marc Hurot, Brice Mayor, Patrik Deleaval, Manolie Mehdi, Charles Chazot
BACKGROUND: Observational studies have recently associated a decrease in serum parathyroid hormone (PTH) level with a higher rate of mortality among hemodialysis (HD) patients. Decreases in PTH level can result from medical intervention (MPD) and surgical parathyroidectomy (PTX), or may occur spontaneously, usually associated with an underlying malnutrition-inflammation syndrome (SPD). The aim of our study was to prospectively identify the incidence of decreases in PTH level in a cohort of HD patients and the frequency distribution of the different causes (MPD, PTX and SPD), as well as to evaluate the survival outcomes for each PTH group (MPD, PTX and SPD) compared to patients who did not experience a PTH decrease over the first 36 months of the study (NPD)...
October 18, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27754829/potential-inflammatory-markers-in-obstructive-sleep-apnea-hypopnea-syndrome
#20
Dongmei Lu, Nanfang Li, Xiaoguang Yao, Ling Zhou
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity and mortality. Serum levels of nuclear factor-κB (NF-κB), hypoxia-inducible factor-1 alpha (HIF-1α), and surfactant protein D (SPD) were investigated in OSAHS patients, to determine their clinical significance and correlation with the pathogenesis. Patients were classified into a mild and moderate OSAHS group (n = 25) and severe OSAHS group (n = 33). Twenty healthy patients served as a control group...
October 18, 2016: Bosnian Journal of Basic Medical Sciences
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