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https://www.readbyqxmd.com/read/28103548/dimensionality-reduction-on-spd-manifolds-the-emergence-of-geometry-aware-methods
#1
Mehrtash Harandi, Mathieu Salzmann, Richard Hartley
Representing images and videos with Symmetric Positive Definite (SPD) matrices, and considering the Riemannian geometry of the resulting space, has been shown to yield high discriminative power in many visual recognition tasks. Unfortunately, computation on the Riemannian manifold of SPD matrices -especially of high-dimensional ones- comes at a high cost that limits the applicability of existing techniques. In this paper, we introduce algorithms able to handle high-dimensional SPD matrices by constructing a lower-dimensional SPD manifold...
January 18, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28096875/sensory-processing-disorders-are-associated-with-duration-of-current-episode-and-severity-of-side-effects
#2
Gianluca Serafini, Batya Engel-Yeger, Gustavo H Vazquez, Maurizio Pompili, Mario Amore
OBJECTIVE: Longer duration of untreated illness, longer duration of current episode, and the severity of medication side effects may negatively impact on the perceived disability and psychosocial impairment of patients with major affective and anxiety disorders. Studies also suggested the involvement of sensory perception in emotional and psychopathological processes. The present study aimed to examine the relationship between Sensory Processing Disorders (SPD), duration of untreated illness and current illness episode, and the severity of side effects related to psychoactive medications...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28092264/centriolar-sas-7-acts-upstream-of-spd-2-to-regulate-centriole-assembly-and-pericentriolar-material-formation
#3
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the centriolar localization of the other components in C. elegans and in humans. However, the molecular basis for SPD-2 centriolar localization remains unknown. Here we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole duplication, assembly and elongation...
January 16, 2017: ELife
https://www.readbyqxmd.com/read/28063396/cold-pressor-pain-in-skin-picking-disorder
#4
Jon E Grant, Sarah A Redden, Samuel R Chamberlain
Excoriation (skin-picking) disorder (SPD) is a disabling, under-recognized condition in which individuals repeatedly pick at their skin, leading to noticeable tissue damage. There has been no examination as to whether individuals with SPD have different pain thresholds or pain tolerances compared to healthy counterparts. Adults with SPD were examined on a variety of clinical measures including symptom severity and functioning. All participants underwent the cold pressor test. Heart rate, blood pressure, and self-reported pain were compared between SPD participants (n=14) and healthy controls (n=14)...
December 31, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28057155/-level-of-soluble-programmed-death-1-ligand-1-in-peripheral-blood-of-patients-with-advanced-epidermal-growth-factor-receptor-mutated-lung-adenocarcinoma-and-its-clinical-implications
#5
L Q Zhang, Y Chen, X Pan, Y F Xing, M H Shi, Y J Chen
Objective: To analyze the expression of soluble programmed death ligand 1 (sPD-L1) in the serum of patients with advanced epidermal growth factor receptor (EGFR) mutated lung adenocarcinoma and to explore its clinical implications. Methods: Seventy-two patients with EGFR mutated advanced lung adenocarcinoma (EGFR mutation group) were included from the Department of Respiratory Diseases in The Second Affiliated Hospital of Soochow University from May 2015 to July 2016. Thirty-one patients with advanced EGFR wild type (WT) lung adenocarcinoma [EGFR WT group, diagnosed via mini specimens from bronchoscopy or transthoracic needle aspiration biopsy (TNAB), matching in sex, age and tumor stage with EGFR mutation group] were also enrolled as controls...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28056053/soluble-b-and-t-lymphocyte-attenuator-correlates-to-disease-severity-in-sepsis-and-high-levels-are-associated-with-an-increased-risk-of-mortality
#6
Anna Lange, Jonas Sundén-Cullberg, Anders Magnuson, Olof Hultgren
INTRODUCTION AND AIMS: B- and T-lymphocyte Attenuator (BTLA), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1 (PD-1) are co-inhibitory receptors that regulate T cell activation. In the present study of ICU-treated patients we measured plasma concentrations of their soluble isoforms, with the aim to evaluate their potential as sepsis biomarkers and utility as prognostic indicators. METHODS: 101 patients with sepsis, 28 patients with non-infectious critical illness (ICU controls) and 31 blood donors (healthy controls, HC) were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28049439/exogenous-spermidine-improves-seed-germination-of-sweet-corn-via-involvement-in-phytohormone-interactions-h2o2-and-relevant-gene-expression
#7
Yutao Huang, Cheng Lin, Fei He, Zhan Li, Yajing Guan, Qijuan Hu, Jin Hu
BACKGROUND: The low seed vigor and poor field emergence are main factors that restricting the extension of sweet corn in China. Spermidine (Spd) plays an important role in plant growth and development, but little is known about the effect of Spd on sweet corn seed germination. Therefore the effect of exogenous Spd on seed germination and physiological and biochemical changes during seed imbibition of Xiantian No.5 were investigated in this study. RESULTS: Spd soaking treatment not only improved seed germination percentage but also significantly enhanced seed vigor which was indicated by higher germination index, vigor index, shoot heights and dry weights of shoot and root compared with the control; while exogenous CHA, the biosynthesis inhibitor of Spd, significantly inhibited seed germination and declined seed vigor...
January 3, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28046604/su-f-t-300-impact-of-electron-density-modeling-of-arccheck-cylindricaldiode-array-on-3dvh-patient-specific-qa-software-tool-analysis
#8
P Patwe, V Mhatre, P Dandekar
PURPOSE: 3DVH software is a patient specific quality assurance tool which estimates the 3D dose to the patient specific geometry with the help of Planned Dose Perturbation algorithm. The purpose of this study is to evaluate the impact of HU value of ArcCHECK phantom entered in Eclipse TPS on 3D dose & DVH QA analysis. METHODS: Manufacturer of ArcCHECK phantom provides CT data set of phantom & recommends considering it as a homogeneous phantom with electron density (1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28007013/dynamic-risk-estimates-of-outcome-in-chinese-patients-with-well-differentiated-thyroid-cancer-after-total-thyroidectomy-and-radioactive-iodine-remnant-ablation
#9
Feng Chih Shen, Ching-Jung Hsieh, I Chin Huang, Yen Hsiang Chang, Pei Wen Wang
Background This study was conducted to compare the staging systems for the prediction of long-term disease status in patients with well-differentiated thyroid carcinoma (WDTC), and find out the earliest postoperative period predictor of long-term persistence/recurrence of disease. Methods Patients with WDTC (n=356, age 41.5 ± 12.7 years) followed for at least 5 years (12.3 ± 5.0 years) after thyroidectomy and 131I remnant ablation at a tertiary regional hospital in Taiwan were retrospectively studied. Each patient was risk-stratified using the American Joint Cancer Committee (AJCC) (stage I-IV), American Thyroid Association (ATA) (low, intermediate, high risk) staging systems after operation and first 131I remnant ablation and using response to initial therapy reclassification (RTR) (excellent, indeterminate, biochemical incomplete, structural incomplete response) system, which is determined 6-24 months after the first 131I ablation...
December 22, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28004823/paclobutrazol-induces-tolerance-in-tomato-to-deficit-irrigation-through-diversified-effects-on-plant-morphology-physiology-and-metabolism
#10
Sikander Pal, Jiangsan Zhao, Asif Khan, Narendra Singh Yadav, Albert Batushansky, Simon Barak, Boris Rewald, Aaron Fait, Naftali Lazarovitch, Shimon Rachmilevitch
Dwindling water resources combined with meeting the demands for food security require maximizing water use efficiency (WUE) both in rainfed and irrigated agriculture. In this regard, deficit irrigation (DI), defined as the administration of water below full crop-water requirements (evapotranspiration), is a valuable practice to contain irrigation water use. In this study, the mechanism of paclobutrazol (Pbz)-mediated improvement in tolerance to water deficit in tomato was thoroughly investigated. Tomato plants were subjected to normal irrigated and deficit irrigated conditions plus Pbz application (0...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27999529/exogenous-ketone-supplements-reduce-anxiety-related-behavior-in-sprague-dawley-and-wistar-albino-glaxo-rijswijk-rats
#11
Csilla Ari, Zsolt Kovács, Gabor Juhasz, Cem Murdun, Craig R Goldhagen, Andrew M Koutnik, Angela M Poff, Shannon L Kesl, Dominic P D'Agostino
Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM)...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27998463/-effects-of-anti-pd-l1-monoclonal-antibody-and-egfr-tki-on-the-expression-of-pd-l1-and-function-of-t-lymphocytes-in-egfr-mutated-lung-cancer-cells
#12
Y She, X Pan, Y F Xing, T Zhou, Z L Zhang, M H Shi, Y J Chen
Objective: To investigate the effects of anti-PD-L1 monoclonal antibody and EGFR-TKI on expression of soluble PD-L1 and function of T lymphocytes in EGFR-mutated lung cancer cells. Methods: Flow cytometry was used to analyze the expression of membrane PD-LI. ELISA was performed to detect the level of sPD-L1 in the supernatant of cultured EGFR-mutated and wild type lung cancer cells before and after erlotinib treatment.After treated with anti-PD-L1 monoclonal antibody alone and in combination with erlotinib, the proliferation of T lymphocytes in co-culture system was measured using Cell Counting Kit-8 (CCK-8) assay...
December 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27993974/the-transcriptional-regulator-cpsy-is-important-for-innate-immune-evasion-in-streptococcus-pyogenes
#13
Luis A Vega, Kayla M Valdes, Ganesh S Sundar, Ashton T Belew, Emrul Islam, Jacob Berge, Patrick Curry, Steven Chen, Najib M El-Sayed, Yoann Le Breton, Kevin S McIver
As an exclusively human pathogen, Streptococcus pyogenes (the Group A Streptococcus, GAS) has specifically adapted to evade host innate immunity and survive in multiple tissue niches, including blood. GAS can overcome the metabolic constraints of the blood environment and expresses various immunomodulatory factors necessary for survival and immune cell resistance. Here we present our investigation of one such factor, the predicted LysR family transcriptional regulator CpsY. The encoding cpsY gene was initially identified as being required for GAS survival in a transposon-site hybridization (TraSH) screen in whole human blood...
December 19, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27990139/cysteine-mediated-gene-expression-and-characterization-of-the-cmbr-regulon-in-streptococcus-pneumoniae
#14
Muhammad Afzal, Irfan Manzoor, Oscar P Kuipers, Sulman Shafeeq
In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39 to cysteine. Transcriptome comparison of the D39 wild-type grown at a restricted concentration of cysteine (0.03 mM) to one grown at a high concentration of cysteine (50 mM) in chemically-defined medium (CDM) revealed elevated expression of various genes/operons, i.e., spd-0150, metQ, spd-0431, metEF, gshT, spd-0618, fhs, tcyB, metB-csd, metA, spd-1898, yvdE, and cysK, likely to be involved in the transport and utilization of cysteine and/or methionine...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27988162/synergetic-role-of-hypromellose-and-methacrylic-acid-copolymer-in-the-dissolution-improvement-of-amorphous-solid-dispersions
#15
Naoko Ohyagi, Keisuke Ueda, Kenjirou Higashi, Keiji Yamamoto, Kohsaku Kawakami, Kunikazu Moribe
Synergetic role of polymer blending on dissolution of amorphous solid dispersion was investigated. Dissolution rates of hypromellose (HPMC) and methacrylic acid copolymer (EUD) from the HPMC/EUD spray-dried sample (SPD) were improved compared to those of each single polymer SPD. Differential scanning calorimetry measurements revealed that the structural change in HPMC following heating was inhibited by co-spray-drying with EUD, suggesting an intermolecular interaction between the polymers. (13)C solid-state NMR spectroscopy detected the change induced in the hydroxyl group of HPMC by co-spray-drying with EUD...
December 14, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27987735/combined-effect-of-grain-refinement-and-surface-modification-of-pure-titanium-on-the-attachment-of-mesenchymal-stem-cells-and-osteoblast-like-saos-2-cells
#16
A E Medvedev, A Neumann, H P Ng, R Lapovok, C Kasper, T C Lowe, V N Anumalasetty, Y Estrin
Surface modification is an important step in production of medical implants. Surface roughening creates additional surface area to enhance the bonding between the implant and the bone. Recent research provided a means to alter the microstructure of titanium by severe plastic deformation (SPD) in order to increase its strength, and thereby reduce the size of the implants (specifically, their diameter). The purpose of the present study was to examine the effect of bulk microstructure of commercially pure titanium with coarse-grained (CG) and ultrafine-grained (UFG) bulk structure on the surface state of these materials after surface modification by sand blasting and acid etching (SLA)...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27957435/spd-based-logistics-management-model-of-medical-consumables-in-hospitals
#17
Tongzhu Liu, Aizong Shen, Xiaojian Hu, Guixian Tong, Wei Gu, Shanlin Yang
BACKGROUND: With the rapid development of health services, the progress of medical science and technology, and the improvement of materials research, the consumption of medical consumables (MCs) in medical activities has increased in recent years. However, owing to the lack of effective management methods and the complexity of MCs, there are several management problems including MC waste, low management efficiency, high management difficulty, and frequent medical accidents. Therefore, there is urgent need for an effective logistics management model to handle these problems and challenges in hospitals...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27941863/coze-is-a-member-of-the-mrecd-complex-that-directs-cell-elongation-in-streptococcus-pneumoniae
#18
Andrew K Fenton, Lamya El Mortaji, Derek T C Lau, David Z Rudner, Thomas G Bernhardt
Most bacterial cells are surrounded by a peptidoglycan cell wall that is essential for their integrity. The major synthases of this exoskeleton are called penicillin-binding proteins (PBPs)(1,2). Surprisingly little is known about how cells control these enzymes, given their importance as drug targets. In the model Gram-negative bacterium Escherichia coli, outer membrane lipoproteins are critical activators of the class A PBPs (aPBPs)(3,4), bifunctional synthases capable of polymerizing and crosslinking peptidoglycan to build the exoskeletal matrix(1)...
December 12, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27921397/nitric-oxide-induced-by-polyamines-involves-antioxidant-systems-against-chilling-stress-in-tomato-lycopersicon-esculentum-mill-seedling
#19
Qian-Nan Diao, Yong-Jun Song, Dong-Mei Shi, Hong-Yan Qi
Polyamines (PAs) and nitric oxide (NO) are vital signals in modulating plant response to abiotic stress. However, to our knowledge, studies on the relationship between NO and PAs in response to cold stress in tomato are limited. Accordingly, in this study, we investigated the effects of putrescine (Put) and spermidine (Spd) on NO generation and the function of Spd-induced NO in the tolerance of tomato seedling under chilling stress. Spd increased NO release via the nitric oxide synthase (NOS)-like and nitrate reductase (NR) enzymatic pathways in the seedlings, whereas Put had no such effect...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27916101/-increased-serum-levels-of-soluble-programmed-death-1-spd-1-and-spd-ligand-1-in-patients-infected-with-brucella
#20
Pan Pang, Yuejie Zhu, Bin Jia, Yan Yang, Jinwei Hu, Yuexin Zhang, Fengbo Zhang, Jianbing Ding
Objective To investigate the alterations of soluble molecule programmed death 1 (sPD-1) and soluble programmed death ligand 1 (sPD-L1), as well as related Th1 cytokines IFN-γ and Th2 cytokines IL-4 in patients infected with Brucella. Methods The study enrolled 56 patients infected with Brucella and 48 healthy controls. Serum sPD-1 and sPD-L1 were detected by ELISA and the levels of Th1/Th2 cytokines were measured with cytometric bead array (CBA). Among them, 37 patients received follow-up. Results Compared with the control group, the serum levels of sPD-1/sPD-L1 and IL-4 increased significantly, while the level of IFN-γ decreased significantly...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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