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https://www.readbyqxmd.com/read/29333980/percentages-of-pd-1-cd4-t-cells-and-pd-l1-dcs-are-increased-and-spd-1-level-is-elevated-in-patients-with-immune-thrombocytopenia
#1
Yingying Wang, Nannan Pang, Xinyou Wang, Ying Liu, Xiujuan Wang, Lei Wang, Mingling Sun, Halida Yasen, Fang Zhao, Wenxia Fan, Jianbing Ding, Xinhong Guo
The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were included in the present study. Twenty healthy subjects who received physical examination at our hospital were included as control group. Peripheral blood was collected from all ITP patients and healthy subjects...
January 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29305750/visual-symptom-provocation-in-skin-picking-disorder-an-fmri-study
#2
Anne Schienle, Sonja Übel, Albert Wabnegger
Skin-picking disorder (SPD) is a common mental disorder characterized by recurrent and excessive picking of dermatological irregularities. Different disorder models have been developed to explain this behavior, but empirical evidence is still scarce. One model (the disgust-related disease avoidance model) suggests that SPD might be understood as pathological grooming elicited by skin imperfections that singal possible infection. Twenty-five women with SPD and 19 matched controls viewed and rated images depicting skin irregularities and smooth skin during functional magnetic resonance imaging...
January 5, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29288375/soluble-programmed-death-1-ligand-1-spd-l1-is-significantly-reduced-in-the-serum-of-type-1-diabetes-patients
#3
Xiaohong Chen, Heming Guo, Sicheng Li, Cuiping Liu, Sisi Ding, Yun Huang, Chen Fang, Ji Hu
No abstract text is available yet for this article.
December 29, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29281779/inhibition-of-autolysis-by-lipase-lipa-in-streptococcus-pneumoniae-sepsis
#4
Gyu-Lee Kim, Truc Thanh Luong, Sang-Sang Park, Seungyeop Lee, Jung Ah Ha, Cuong Thach Nguyen, Ji Hye Ahn, Ki-Tae Park, Man-Jeong Paik, Suhkneung Pyo, David E Briles, Dong-Kwon Rhee
More than 50% of sepsis cases are associated with pneumonia. Sepsis is caused by infiltration of bacteria into the blood via inflammation, which is triggered by the release of cell wall components following lysis. However, the regulatory mechanism of lysis during infection is not well defined. Mice were infected with Streptococcus pneumoniae D39 wild-type (WT) and lipase mutant (ΔlipA) intranasally (pneumonia model) or intraperitoneally (sepsis model), and survival rate and pneumococcal colonization were determined...
December 26, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29240775/ornithine-decarboxylase-as-a-therapeutic-target-for-endometrial-cancer
#5
Hong Im Kim, Chad R Schultz, Andrea L Buras, Elizabeth Friedman, Alyssa Fedorko, Leigh Seamon, Gadisetti V R Chandramouli, G Larry Maxwell, André S Bachmann, John I Risinger
Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and confirmed this in the cancer genome atlas (TCGA) with highest expression in non-endometrioid, high grade, and copy number high cancers, which have the worst clinical outcomes. ODC1 expression was associated with worse overall survival and increased recurrence in three endometrial cancer gene expression datasets...
2017: PloS One
https://www.readbyqxmd.com/read/29240144/1-25%C3%A2-%C3%A2-ghz-sine-wave-gating-ingaas-inp-single-photon-detector-with-a-monolithically-integrated-readout-circuit
#6
Wen-Hao Jiang, Jian-Hong Liu, Yin Liu, Ge Jin, Jun Zhang, Jian-Wei Pan
InGaAs/InP single-photon detectors (SPDs) are the key devices for applications requiring near-infrared single-photon detection. The gating mode is an effective approach to synchronous single-photon detection. Increasing gating frequency and reducing the module size are important challenges for the design of such a detector system. Here we present for the first time, to the best of our knowledge, an InGaAs/InP SPD with 1.25 GHz sine wave gating (SWG) using a monolithically integrated readout circuit (MIRC)...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29239473/polyamines-regulating-phytic-acid-degradation-in-mung-bean-sprouts
#7
Ting Zhou, Pei Wang, Runqiang Yang, Zhenxin Gu
BACKGROUND: Polyamines are essentially involved in cell division and differentiation. Transport of polyamine is ATP dependent, while phytic acid is the major reserve of phosphate essential to the energy-producing machinery of cells. Thus, polyamines might enhance phytic acid degradation during mung bean germination. In this study, different polyamines [putrescine (Put), spermidine (Spd) and spermine (Spm)] and dicyclohexylamine (DCHA, a Spd synthesis inhibitor) were applied to investigate the function of polyamines on phytic acid degradation...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29233903/clinical-significance-of-pd-l1-exosomes-in-plasma-of-head-and-neck-cancer-patients
#8
Marie-Nicole Theodoraki, Saigopalakrishna Yerneni, Thomas K Hoffmann, William E Gooding, Theresa L Whiteside
PURPOSE: The microenvironment of head and neck squamous cell carcinomas (HNSCCs) is highly immunosuppressive. HNSCCs expressing elevated levels of PD-L1 have especially poor outcome. Exosomes that carry PD-L1 and suppress T-cell functions have been isolated from plasma of patients with HNSCC. The potential contributions of PD-L1+ exosomes to immune suppression and disease activity are evaluated. METHODS: Exosomes isolated from plasma of 40 HNSCC patients by size exclusion chromatography were captured on beads using anti-CD63 Abs, stained for PD-1 and PD-L1 and analyzed by flow cytometry...
December 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29224265/-analysis-on-the-clinical-therapeutic-effects-of-arterial-first-approach-pancreatoduodenectomy-in-the-treatment-of-borderline-resectable-pancreatic-adenocarcinoma
#9
G Jin, K L Zheng, S W Guo, Z Shao, C Liu, X H Shi, R D Liu, S J Bai, H Jiang, Y Bian, X G Hu
Objective: To compare the clinical therapeutic effects of arterial first approach pancreaticoduodenectomy(AFA-PD) with standard approach pancreaticoduodenectomy(SPD) in the treatment of borderline resectable pancreatic cancer (BRPC). Methods: A retrospective analysis of the clinical data of 113 cases of pancreatic cancer patients from January 2014 to August 2015 at Department of Hepato-Biliary-Pancreatic Surgery, Changhai Hospital, the Second Military Medical University, including 43 cases in AFA-PD group and 70 cases in SPD group...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29222174/phosphatase-pp2a-and-microtubule-mediated-pulling-forces-disassemble-centrosomes-during-mitotic-exit
#10
Stephen J Enos, Martin Dressler, Beatriz Ferreira Gomes, Anthony A Hyman, Jeffrey B Woodruff
Centrosomes are microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass of protein called pericentriolar material (PCM) from which microtubules nucleate. During each cell cycle, PCM accumulates around centrioles through phosphorylation-mediated assembly of PCM scaffold proteins. During mitotic exit, PCM swiftly disassembles by an unknown mechanism. Here, we used Caenorhabditis elegans embryos to determine the mechanism and importance of PCM disassembly in dividing cells...
December 8, 2017: Biology Open
https://www.readbyqxmd.com/read/29218753/neuronal-responses-to-the-scratching-and-caressing-of-one-s-own-skin-in-patients-with-skin-picking-disorder
#11
Anne Schienle, Sonja Übel, Albert Wabnegger
Skin-picking disorder (SPD) is a common mental disorder. The predominant symptom involves the repeated scratching and picking of one's own skin. This behavior causes severe tissue damage (sores, scars, and infections), often leading to disfigurement. Besides physical injury, SPD is associated with clinically significant distress and impairment in important areas of functioning. The neurobiological mechanisms of SPD are still poorly understood. In this study, 30 SPD patients and 31 control participants (35 women, 26 men) with a mean age of 34 years were instructed to either scratch or gently stroke a small skin area on their arms during functional magnetic resonance imaging...
December 7, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29216408/a-cold-responsive-erf-from-medicago-falcata-confers-cold-tolerance-by-up-regulation-of-polyamine-turnover-antioxidant-protection-and-proline-accumulation
#12
Chunliu Zhuo, Lu Liang, Yaqing Zhao, Zhenfei Guo, Shaoyun Lu
ERF subfamily transcription factors play an important role in plant abiotic and biotic stress tolerance. A cold responsive ethylene responsive factor (ERF), MfERF1, was isolated from Medicago falcata, an important forage legume that has great cold tolerance. Overexpression of MfERF1 resulted in an increased tolerance to freezing and chilling in transgenic tobacco plants, while down-regulation of the ortholog of MfERF1 in M. truncatula resulted in reduced freezing tolerance in RNAi plants. Higher transcript levels of some stress responsive genes (CHN50, OSM, ERD10C, and SAMS) and those involved in spermidine (Spd) and spermine (Spm) synthesis (SAMDC1, SAMDC2, SPDS1, SPDS2, and SPMS) and catabolism (PAO) were observed in transgenic plants than in WT...
December 7, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29205636/immune-checkpoint-molecules-soluble-program-death-ligand-1-and-galectin-9-are-increased-in-pregnancy
#13
Elizabeth Ann L Enninga, Susan M Harrington, Douglas J Creedon, Rodrigo Ruano, Svetomir N Markovic, Haidong Dong, Roxana S Dronca
PROBLEM: Pregnancy requires balance between tolerance to the haploidentical fetus and the mother's ability to mount immune responses. There are parallels to this phenomenon that occur in metastatic cancer. We assessed soluble program death ligand-1 soluble PD-L1 (sPD-L1) and galectin-9 in the blood of pregnant women during gestation as these molecules are highly involved in immune suppression during cancer. METHOD OF STUDY: Maternal blood was collected from 30 primigravida women at monthly intervals during pregnancy, delivery and 6-week post-partum...
December 4, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29181982/catalytic-asymmetric-cascade-using-spiro-pyrrolidine-organocatalyst-efficient-construction-of-hydrophenanthridine-derivatives
#14
Jin-Miao Tian, Yong-Hai Yuan, Yu-Yang Xie, Shu-Yu Zhang, Wen-Qiang Ma, Fu-Min Zhang, Shao-Hua Wang, Xiao-Ming Zhang, Yong-Qiang Tu
A newly developed SPD (spiro-pyrrolidine) organocatalyst has been demonstrated to enable an asymmetric aza-Michael/Michael/aldol cyclization cascade, in which two six-membered rings (B/C) and three stereocenters have been constructed in a catalytic one-step process. It is so far the most efficient method for construction of hydrophenanthridine derivatives featuring high enantioselectivity. The trans- or cis-fused B/C-rings can be selectively assembled in a substrate-controlled manner. Moreover, this cascade could magnify to gram scale without loss of enanioselectivity...
November 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/29171494/-the-clinical-features-of-parkinson-s-disease-in-patients-with-mutations-and-polymorphic-variants-of-gba-gene
#15
K A Senkevich, I V Miliukhina, M V Beletskaia, E V Gracheva, A V Kudrevatykh, M A Nikolaev, A K Emelyanov, A E Kopytova, A A Timofeeva, A F Yakimovskii, S N Pchelina
BACKGROUND: Mutations in the glucocerebrosidase gene (GBA) increase the risk of Parkinson's disease (PD) by 6-10 times in all populations and are associated with the early-onset of PD, development of cognitive impairment and presence of psychotic disorders. At the same time, polymorphic variants associated with the twofold increase in the risk of PD were also described in the GBA gene. AIM: To estimate the clinical features of PD in patients with mutations and polymorphic variants of the GBA gene...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29167050/insecure-attachment-style-and-cumulative-traumatic-life-events-in-patients-with-somatoform-pain-disorder-a-cross-sectional-study
#16
Yeliz Nacak, Eva Morawa, Daniela Tuffner, Yesim Erim
OBJECTIVE: Current models assume somatoform pain disorder (SPD) to be the result of a complex interaction between bio- and psychosocial factors, but the etiology is still not well understood. This study aimed to investigate the distribution of attachment style and the frequency of traumatic life events, especially childhood adversities, in patients with SPD compared to healthy controls. METHODS: We compared 65 patients with SPD (confirmed by Structured Clinical Interview, SCID-I) to 65 age- and gender-matched healthy controls...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29164344/theoretical-investigation-on-the-covalence-in-agrnx-and-xagrn-x%C3%A2-%C3%A2-f-i
#17
Li Xinying
CCSD(T) calculations were performed to investigate the stabilities and interaction mechanisms of the AgRnX and XAgRn (X = F - I) series. Dissociation energies and frontier orbital properties demonstrate an increased trend of stabilities. Ag spd hybrids and Rn/X sp hybrids come into the σAg-Rn and σAg-X bonding orbital. The nature of Ag-Rn, Ag-X and Rn-X interactions were investigated by atoms in molecules (AIM) theory. The negative energy density and positive Laplacian values, as well as small electron densities at bond critical points (BCPs), characterize the moderate strength with partial covalence of interactions...
November 21, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29163108/alterations-in-white-matter-integrity-in-young-adults-with-smartphone-dependence
#18
Yuanming Hu, Xiaojing Long, Hanqing Lyu, Yangyang Zhou, Jianxiang Chen
Smartphone dependence (SPD) is increasingly regarded as a psychological problem, however, the underlying neural substrates of SPD is still not clear. High resolution magnetic resonance imaging provides a useful tool to help understand and manage the disorder. In this study, a tract-based spatial statistics (TBSS) analysis on diffusion tensor imaging (DTI) was used to measure white matter integrity in young adults with SPD. A total of 49 subjects were recruited and categorized into SPD and control group based on their clinical behavioral tests...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29161157/event-specific-cannabis-use-and-cannabis-use-motives
#19
Julia D Buckner, Katherine A Walukevich, Amber M Henslee
BACKGROUND: Specific events such as Mardi Gras (MG) and St. Patrick's Day (SPD) have been identified as high-risk events for cannabis use. Further, some campuses may have traditions that are associated with more event-specific cannabis use. OBJECTIVES: Campus A has specific traditions regarding MG whereas Campus B has specific traditions regarding SPD and these campuses are differentially related to event-specific cannabis use (Buckner, Henslee, & Jeffries, 2015 )...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29145113/denitrification-behavior-and-microbial-community-spatial-distribution-inside-woodchip-based-solid-phase-denitrification-w-spd-bioreactor-for-nitrate-contaminated-water-treatment
#20
Jiamin Zhao, Chuanping Feng, Shuang Tong, Nan Chen, Shanshan Dong, Tong Peng, Shunlong Jin
The NO3(-) removal pathway and microorganisms change along with the height of an up-flow W-SPD bioreactor was investigated in this study. Modeling and microbial community analysis were used to analyze the denitrification behavior in W-SPD bioreactor. The results showed that NO3(-) removal rate matched for zero-order (R(2) > 0.97) and first-order (R(2) > 0.94) combination Michaelis-Menten kinetics, whereas microbial reaction rate suited for modified logistic model (R(2) > 0.99). The excellent denitrification performance (92...
November 6, 2017: Bioresource Technology
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