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https://www.readbyqxmd.com/read/28930374/the-prognostic-significance-of-soluble-programmed-death-ligand-1-expression-in-cancers-a-systematic-review-and-meta-analysis
#1
REVIEW
Y Ding, C Sun, J Li, L Hu, M Li, J Liu, L Pu, S Xiong
The differential expression of soluble programmed death ligand 1 (sPD-L1) has been found in some cancers; however, the correlation between sPD-L1 expression and prognosis value in tumour is still unclear. Here, we conducted a meta-analysis and systematic review to assess the prognostic value of sPD-L1 in patients with cancer. Eligible studies were searched for in the databases including PubMed, Web of Science, ScienceDirect and Wiley Online Library database. The pooled hazard ratios (HRs) with a 95% confidence interval (95%CI) were calculated to assess the prognostic significance of sPD-L1 in human cancer...
August 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28930067/prenatal-exposure-effects-on-early-adolescent-substance-use-preliminary-evidence-from-a-genetically-informed-bayesian-approach
#2
L Cinnamon Bidwell, Kristine Marceau, Leslie A Brick, Hollis C Karoly, Alexandre A Todorov, Rohan H Palmer, Andrew C Heath, Valerie S Knopik
OBJECTIVE: Given the controversy surrounding the question of whether there are direct or causal effects of exposure to maternal smoking during pregnancy (SDP) on offspring outcomes such as substance use during the adolescent years, we sought to test, on a preliminary basis, within- and between-family associations of SDP and initiation of substance use early in adolescence (by age 15 years) using a discordant sibling design. METHOD: We used a sibling-comparison approach in a sample of 173 families drawn from the state of Missouri, wherein mothers were discordant for smoking behaviors between two different pregnancies, to test for associations of SDP and initiation of substance use in a younger adolescent cohort...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28919686/high-performance-liquid-chromatography-ultraviolet-photodiode-array-detection-method-for-aflatoxin-b1-in-cattle-feed-supplements
#3
Lazuardi Mochamad, Bambang Hermanto
AIM: The objective of the current study is to determine the concentration of aflatoxin B1 using high-performance liquid chromatography (HPLC) with a photodiode array (PDA) detector. MATERIALS AND METHODS: Aflatoxin B1 certified reference grade from Trilogy Analytical Laboratory dissolved acetonitrile (ACN) at 10 µg/mL was using standard assessment. HPLC instruments such as ultraviolet-PDA detector used a Shimadzu LC-6AD pump with DGU-20A5 degasser, communication module-20A, and PDA detector SPD-M20A with FRC-10A fraction collector...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28918268/a-structural-mri-study-of-excoriation-skin-picking-disorder-and-its-relationship-to-clinical-severity
#4
Michael D Harries, Samuel R Chamberlain, Sarah A Redden, Brian L Odlaug, Austin W Blum, Jon E Grant
Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28910277/interplay-between-microtubule-bundling-and-sorting-factors-ensures-acentriolar-spindle-stability-during-c-elegans-oocyte-meiosis
#5
Timothy J Mullen, Sarah M Wignall
In many species, oocyte meiosis is carried out in the absence of centrioles. As a result, microtubule organization, spindle assembly, and chromosome segregation proceed by unique mechanisms. Here, we report insights into the principles underlying this specialized form of cell division, through studies of C. elegans KLP-15 and KLP-16, two highly homologous members of the kinesin-14 family of minus-end-directed kinesins. These proteins localize to the acentriolar oocyte spindle and promote microtubule bundling during spindle assembly; following klp-15/16 depletion, microtubule bundles form but then collapse into a disorganized array...
September 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28885387/evidence-for-persistent-immune-suppression-in-patients-who-develop-chronic-critical-illness-after-sepsis
#6
Julie A Stortz, Tyler J Murphy, Steven L Raymond, Juan C Mira, Ricardo Ungaro, Marvin L Dirain, Dina C Nacionales, Tyler J Loftus, Zhongkai Wang, Tezcan Ozrazgat-Baslanti, Gabriela L Ghita, Babette A Brumback, Alicia M Mohr, Azra Bihorac, Philip A Efron, Lyle L Moldawer, Frederick A Moore, Scott C Brakenridge
BACKGROUND: Many sepsis survivors develop chronic critical illness (CCI) and are assumed to be immunosuppressed, but there is limited clinical evidence to support this. We sought to determine whether the incidence of secondary infections and immunosuppressive biomarker profiles of patients with CCI differ from those with rapid recovery (RAP) after sepsis. METHODS: This prospective observational study evaluated 88 critically ill patients with sepsis and 20 healthy controls...
September 6, 2017: Shock
https://www.readbyqxmd.com/read/28878165/mitochondrial-liver-toxicity-of-valproic-acid-and-its-acid-derivatives-is-related-to-inhibition-of-945-lipoamide-dehydrogenase
#7
Alexei P Kudin, Hafiz Mawasi, Arik Eisenkraft, Christian E Elger, Meir Bialer, Wolfram S Kunz
The liver toxicity of valproic acid (VPA) is an established side effect of this widely used antiepileptic drug, which is extremely problematic for patients with metabolic epilepsy and particularly epilepsy due to mitochondrial dysfunction. In the present report, we investigated the reason for liver mitochondrial toxicity of VPA and several acid and amide VPA analogues. While the pyruvate and 2-oxoglutarate oxidation rates of rat brain mitochondria were nearly unaffected by VPA, rat liver mitochondrial pyruvate and 2-oxoglutarate oxidation was severely impaired by VPA concentrations above 100 µM...
September 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28871711/analysis-of-the-rs13306560-functional-variant-in-the-promoter-region-of-the-mthfr-gene-in-sporadic-parkinson%C3%A2-s-disease
#8
Silvia García, Luis Javier Cano-Martínez, Ramón Mauricio Coral-Vázquez, Agustín Coronel-Perez, Benjamín Gómez-Díaz, Christian Gabriel Toledo-Lozano, Martha Patricia Gallegos-Arreola, Luis Dávila-Maldonado, Dulce Adeí Jimenez-Hernández, Sofía Lizeth Alcaraz-Estrada, Luz Berenice López-Hernández
OBJECTIVE: Among susceptibility genes for Sporadic Parkinson´s Disease (SPD), the MTHFR gene has been suggested as candidate. The A allele of the functional variant rs13306560 in its promoter region has been liked to decreased transactivation capacity. Therefore, we sought to determine a possible association of the rs13306560 and SPD. METHODS: In total, 237 individuals were genotyped, 113 patients with SPD diagnosed according to the Queen Square Brain Bank criteria and 124 neurologically healthy controls...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28867618/leucine-responsive-regulatory-protein-is-involved-in-methionine-metabolism-and-polyamine-homeostasis-in-acetic-acid-bacterium-komagataeibacter-europaeus
#9
Yuri Ishii, Naoki Akasaka, Hisao Sakoda, Ryota Hidese, Shinsuke Fujiwara
The leucine responsive regulatory protein (Lrp) is a global transcription factor that regulates the expression of genes involved in amino acid metabolism. To identify metabolic pathways and related genes under the control of Lrp in the acetic acid bacterium Komagataeibacter europaeus, the Kelrp null mutant (KGMA7110), which requires supplementation of all 20 amino acids for normal growth, was cultivated in minimal media containing or lacking particular amino acids. The results confirmed that KGMA7110 was auxotrophic for methionine and its catabolites S-adenosylmethionine (SAM) and spermidine (SPD)...
August 31, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28866131/increased-emotional-reactivity-to-affective-pictures-in-patients-with-skin-picking-disorder-evidence-from-functional-magnetic-resonance-imaging
#10
Albert Wabnegger, Sonja Übel, Gerald Suchar, Anne Schienle
The predominant symptom of skin-picking disorder (SPD) is the recurrent picking of one's own skin, leading to tissue damage and discomfort. Psychological disorder models suggest an enhanced emotional reactivity in patients with SPD, which contributes to the maintenance of symptoms. This functional magnetic resonance imaging (fMRI) experiment analyzed both subjective and neuronal responses to affective pictures (categories: fear, disgust, happiness, neutral) in 19 women with SPD and 16 healthy controls. Also, affective traits (disgust, anxiety, depression) were assessed...
September 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28864907/alterations-in-the-reduced-pteridine-contents-in-the-cerebrospinal-fluids-of-lrrk2-mutation-carriers-and-patients-with-parkinson-s-disease
#11
Hiroshi Ichinose, Ken-Ichi Inoue, Shinobu Arakawa, Yuki Watanabe, Hiroki Kurosaki, Shoko Koshiba, Eldbjorg Hustad, Masahiko Takada, Jan O Aasly
Tetrahydrobiopterin (BH4) is a cofactor for tyrosine hydroxylase that is essential for the biosynthesis of dopamine. Parkinson's disease (PD) is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons, and biomarkers reflecting the degree of neurodegeneration are important not only for basic research but also for clinical diagnosis and the treatment of the disease. Although the total neopterin and biopterin levels in the cerebrospinal fluids (CSF) of the patients with PD were reported, alterations in the composition of reduced and oxidized forms of pteridine compounds have not been examined...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28852317/pancreaticoduodenectomy-for-duodenal-papilla-carcinoma-a-single-centre-9-year-retrospective-study-of-112-patients-with-long-term-follow-up
#12
Pei-Long Lian, Yuan Chang, Xiu-Chun Xu, Zhen Zhao, Xian-Qiang Wang, Ke-Sen Xu
AIM: To retrospectively evaluate the factors that influence long-term outcomes of duodenal papilla carcinoma (DPC) after standard pancreaticoduodenectomy (SPD). METHODS: This is a single-centre, retrospective study including 112 DPC patients who had a SPD between 2006 and 2015. Associations between serum levels of CA19-9 and CEA and various clinical characteristics of 112 patients with DPC were evaluated by the χ(2) test and Fisher's exact test. The patients were followed-up every 3 mo in the first two years and at least every 6 mo afterwards, with a median follow-up of 60 mo (ranging from 4 mo to 168 mo)...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28841546/transfer-learning-a-riemannian-geometry-framework-with-applications-to-brain-computer-interfaces
#13
Paolo Zanini, Marco Congedo, Christian Jutten, Salem Said, Yannick Berthoumieu
OBJECTIVE: This paper tackles the problem of transfer learning in the context of EEG-based Brain Computer Interface (BCI) classification. In particular the problems of cross-session and cross-subject classification are considered. These problems concern the ability to use data from previous sessions or from a database of past users to calibrate and initialize the classifier, allowing a calibration-less BCI mode of operation. METHODS: Data are represented using spatial covariance matrices of the EEG signals, exploiting the recent successful techniques based on the Riemannian geometry of the manifold of Symmetric Positive Definite (SPD) matrices...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28839101/hyperoxia-treatment-of-trek-1-trek-2-traak-deficient-mice-is-associated-with-a-reduction-in-surfactant-proteins
#14
Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean L Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M Waters
We previously proposed a role for the 2-pore domain potassium (K2P) channel TREK-1 in hyperoxia (HO)-induced lung injury. To determine whether redundancy between the 3 TREK isoforms (TREK-1, TREK-2, TRAAK) could protect from HO-induced injury, we now examined the effect of deletion of all 3 TREK isoforms in a clinically relevant scenario of prolonged HO exposure and mechanical ventilation (MV). We exposed WT and TREK-1/TREK-2/TRAAK-deficient (triple ko) mice to either room air, 72 hours HO, MV (high and low tidal volume), or a combination of HO+MV, and measured quasi-static lung compliance, BAL protein concentration, histologic lung injury scores (LIS), cellular apoptosis, and cytokine levels...
August 24, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28828316/the-application-of-collaborative-business-intelligence-technology-in-the-hospital-spd-logistics-management-model
#15
Tongzhu Liu, Aizong Shen, Xiaojian Hu, Guixian Tong, Wei Gu
BACKGROUND: We aimed to apply collaborative business intelligence (BI) system to hospital supply, processing and distribution (SPD) logistics management model. METHODS: We searched Engineering Village database, China National Knowledge Infrastructure (CNKI) and Google for articles (Published from 2011 to 2016), books, Web pages, etc., to understand SPD and BI related theories and recent research status. For the application of collaborative BI technology in the hospital SPD logistics management model, we realized this by leveraging data mining techniques to discover knowledge from complex data and collaborative techniques to improve the theories of business process...
June 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28817100/modulatory-effects-of-exogenously-applied-polyamines-on-postharvest-physiology-antioxidant-system-and-shelf-life-of-fruits-a-review
#16
REVIEW
Sunil Sharma, Sunil Pareek, Narashans Alok Sagar, Daniel Valero, Maria Serrano
Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shelf life of fruits. They also originate endogenously during developmental phases of horticultural crops and simultaneously affect the quality attributes and shelf life. Their anti-ethylene nature is being exploited to enhance the shelf life when exogenously applied on fruits...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28815856/molecular-dynamics-insights-into-polyamine-dna-binding-modes-implications-for-cross-link-selectivity
#17
Emmanuelle Bignon, Chen-Hui Chan, Christophe Morell, Antonio Monari, Jean-Luc Ravanat, Elise Dumont
Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines-putrescine (Put), spermine (Spm), and spermidine (Spd)-with a self-complementary 16 base pair (bp) duplex, are investigated by all-atom explicit-solvent molecular dynamics. The length of the amine aliphatic chain leads to a change of the interaction mode from minor groove binding to major groove binding...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28797561/self-reported-psychosis-like-experiences-in-patients-with-mood-disorders
#18
I Baryshnikov, J Suvisaari, K Aaltonen, M Koivisto, T Melartin, P Näätänen, K Suominen, B Karpov, M Heikkinen, J Oksanen, T Paunio, G Joffe, E Isometsä
BACKGROUND: Self-reported psychosis-like experiences (PEs) may be common in patients with mood disorders, but their clinical correlates are not well known. We investigated their prevalence and relationships with self-reported symptoms of depression, mania, anxiety, borderline (BPD) and schizotypal (SPD) personality disorders among psychiatric patients with mood disorders. METHODS: The Community Assessment of Psychic Experiences (CAPE-42), Mood Disorder Questionnaire (MDQ), McLean Screening Instrument (MSI), The Beck Depressive Inventory (BDI), Overall Anxiety Severity and Impairment Scale (OASIS) and Schizotypal Personality Questionnaire-Brief form (SPQ-B) were filled in by patients with mood disorders (n=282) from specialized care...
February 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28794915/occurrence-of-synpolydactyly-and-omphalocele-in-a-fetus-with-a-hoxd13-mutation
#19
Periyasamy Radhakrishnan, Shalini S Nayak, Muralidhar V Pai, Anju Shukla, Katta M Girisha
Synpolydactyly (SPD) is an autosomal dominant congenital limb disorder due to mutations in HOXD13 . It is a phenotypically heterogeneous condition characterized by syndactyly of the third finger (F3), fourth finger (F4) and/or fourth toe (T4), and fifth toe (T5) with variably associated polydactyly. We report on a mother and fetus with SPD. The mother has a novel mutation (c.708_708delC) in the HOXD13 gene that was also seen in the fetus. However, the fetus had congenital omphalocele in addition to SPD that is an association not reported to date...
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28773176/color-shift-failure-prediction-for-phosphor-converted-white-leds-by-modeling-features-of-spectral-power-distribution-with-a-nonlinear-filter-approach
#20
Jiajie Fan, Moumouni Guero Mohamed, Cheng Qian, Xuejun Fan, Guoqi Zhang, Michael Pecht
With the expanding application of light-emitting diodes (LEDs), the color quality of white LEDs has attracted much attention in several color-sensitive application fields, such as museum lighting, healthcare lighting and displays. Reliability concerns for white LEDs are changing from the luminous efficiency to color quality. However, most of the current available research on the reliability of LEDs is still focused on luminous flux depreciation rather than color shift failure. The spectral power distribution (SPD), defined as the radiant power distribution emitted by a light source at a range of visible wavelength, contains the most fundamental luminescence mechanisms of a light source...
July 18, 2017: Materials
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