Read by QxMD icon Read

pattern separation

Sang Mun Bae, Dong-Jun Bae, Eun-Ju Do, Gyungseok Oh, Su Woong Yoo, Gil-Je Lee, Ji Soo FChae, Youngkuk Yun, Sungjee Kim, Ki Hean Kim, Euiheon Chung, Jun Ki Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Jinmyoung Joo, Sang-Yeob Kim, Seung-Jae Myung
BACKGROUND AND STUDY AIM: To develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions. METHODS: Newly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference due to autofluorescence and multiplex fluorophores in fluorescent probes. The multiplexing capability of the multi-spectral endoscope device was demonstrated in the phantom studies and multi-spectral imaging with endoscopy and macroscopy was performed to analyze fluorescence signals after administration of fluorescent probe that targets cancer in the colon...
November 9, 2018: Translational Oncology
David J Schaeffer, Kyle M Gilbert, Maryam Ghahremani, Joseph S Gati, Ravi S Menon, Stefan Everling
The common marmoset (Callithrix jacchus) has garnered recent attention as a potentially powerful preclinical model and complement to other canonical mammalian models of human brain diseases (e.g., rodents and Old World non-human primates). With a granular frontal cortex and the advent of transgenic modifications, marmosets are well positioned to serve as neuropsychiatric models of prefrontal cortex dysfunction. A critical step in the development of marmosets for such models is to characterize functional network topologies of frontal cortex in healthy, normally functioning marmosets...
November 9, 2018: NeuroImage
Markus Waser, Martin J Lauritzen, Birgitte Fagerlund, Merete Osler, Erik L Mortensen, Helge B D Sørensen, Poul Jennum
Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders. Little is known, however, about the relation of sleep and the gradual cognitive changes over the adult life course. Sleep electroencephalogram (EEG) patterns are potential markers of the cognitive progress. To test this hypothesis, we assessed sleep architecture and EEG of 167 men born in the Copenhagen Metropolitan Area in 1953, who, based on individual cognitive testing from early (~18 years) to late adulthood (~58 years), were divided into 85 subjects with negative and 82 with positive cognitive change over their adult life...
November 12, 2018: Journal of Sleep Research
Sheng-Yao Chang, Ming-Yuan Lee, Ching-Chou Wu
A microchip electrophoresis (ME) device with off-channel contact conductivity detection (C2 D) was constructed using top-bottom antiparallel indium tin oxide (ITO) electrodes and a cross-type microchannel. The 500-m wide top-bottom antiparallel decouplers were found to effectively decrease the interference of the electrophoretic current. The cross-type microchannel was formed by bonding the patterned negative photoresist microstructures and the two top-bottom opposed ITO-deposited glass substrates. Five seconds of 150 V/cm injection field and the 100 V/cm separation field equipped with the C2 D of AC 200 mV excitation voltage provided adequate ME operational parameters to obtain the K+ and Na+ peaks separation...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Laura Rowe, Grace Burkhart
Ultrahigh performance liquid chromatography (UHPLC) uses small stationary-phase particle size (<2 μm) and high pressure in order to achieve rapid and efficient separations. The speed and high resolution of this method has made it a valuable tool for analyzing the complex glycosylation patterns found in post-translationally modified proteins. This article highlights the differences between UHPLC and HPLC and reviews recent UHPLC applications and developments for detecting glycosylated proteins (e.g., glycomics studies) and characterizing glycosylated pharmaceuticals (e...
October 1, 2018: Bioanalysis
Matthew D Schlesinger, Jeremy A Feinberg, Nathan H Nazdrowicz, J D Kleopfer, Jeffrey C Beane, John F Bunnell, Joanna Burger, Edward Corey, Kathy Gipe, Jesse W Jaycox, Erik Kiviat, Jacob Kubel, Dennis P Quinn, Christopher Raithel, Peter A Scott, Sarah M Wenner, Erin L White, Brian Zarate, H Bradley Shaffer
Cryptic species are a challenge for systematics, but their elucidation also may leave critical information gaps about the distribution, conservation status, and behavior of affected species. We use the leopard frogs of the eastern U.S. as a case study of this issue. We refined the known range of the recently described Rana kauffeldi, the Atlantic Coast Leopard Frog, relative to the region's two other leopard frog species, conducted assessments of conservation status, and improved methods for separating the three species using morphological field characters...
2018: PloS One
Florian Giesche, Frieder Krause, Daniel Niederer, Jan Wilke, Tobias Engeroff, Lutz Vogt, Winfried Banzer
BACKGROUND: Low back pain patients have been suggested to exhibit dysfunctional spinal movement patterns. However, there is a lack of clinically applicable but valid and reliable assessment tools, helping to discriminate normal and pathologically altered movement. OBJECTIVE: We aimed to examine whether kinematic parameters determined with an ultrasound-based motion analysis and thereof derived chromokinegraphical angle-time matrices (CATMAs) are able to discriminate between non-symptomatic and symptomatic movement behaviour in individuals with non-specific chronic (CLBP), specific low back pain (SLBP), and controls...
November 1, 2018: Journal of Back and Musculoskeletal Rehabilitation
S Grundmann, F Trinter, A W Bray, S Eckart, J Rist, G Kastirke, D Metz, S Klumpp, J Viefhaus, L Ph H Schmidt, J B Williams, R Dörner, T Jahnke, M S Schöffler, A S Kheifets
We report on a kinematically complete measurement of double ionization of helium by a single 1100 eV circularly polarized photon. By exploiting dipole selection rules in the two-electron continuum state, we observed the angular emission pattern of electrons originating from a pure quadrupole transition. Our fully differential experimental data and companion ab initio nonperturbative theory show the separation of dipole and quadrupole contributions to photo-double-ionization and provide new insight into the nature of the quasifree mechanism...
October 26, 2018: Physical Review Letters
Yun Guo, Chen Liang, Xiao Wen Li
Yellow River basin is a significant habitat for biodiversity conservation in China. Here, we established a integrated classification system of wetlands based on climate types and geomorphological units, with which as the coarse-filter surrogates of biodiversity elements to complement the fine-filter surrogates of distribution of focal bird species. Then, we applied the theoretical framework of systematic conservation planning (SCP), with those two biodiversity surrogates as protection objects and watershed as planning units...
September 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Dahliatul Qosimah, Sri Murwani, Edhy Sudjarwo, M Arfan Lesmana
Background and Aim: Newcastle disease virus (NDV) is an obligate intracellular parasite. Virus can only live on living cells. The embryonated chicken eggs (ECEs) are one of the growth media of virus that is a cheap, easy to do, and accurate for showing patterns of virus change in the host. Higher virus titers indicate the higher number of viruses and more virulent to infect host. This research aimed to investigate the effect of different level of NDV titer infection in ECEs on protein profile, embryonic length, mortality, and pathological change...
September 2018: Veterinary World
Jae-Myeong Lee, Hyo-Jo Han, Won-Kyu Choi, Subin Yoo, Soojin Baek, Jaemin Lee
BACKGROUND: The ratio of T helper 1 (Th1) to T helper 2 (Th2) as well as T helper 17 (Th17) to regulatory T cells (Treg) represents the state and direction of immune response. Recent studies demonstrated that dexmedetomidine reduced the secretion of inflammatory cytokines. We performed this study to investigate the effect of different doses of intraoperative dexmedetomidine on the expression of Th1, Th2, T17 and Treg cytokines and their ratios. METHODS: Seventy-five patients undergoing laparoscopic cholecystectomy were randomly separated into one of three groups: the full dose group (n = 25), in which dexmedetomidine was infused with a 1...
November 8, 2018: BMC Anesthesiology
Yongtian Luo, Lutz Maibaum
We study the phase behavior of multicomponent lipid bilayer vesicles that can exhibit intriguing morphological patterns and lateral phase separation. We use a modified Landau-Ginzburg model capable of describing spatially uniform phases, microemulsions, and modulated phases on a spherical surface. We calculate its phase diagram for multiple vesicle sizes using analytical and numerical techniques as well as Monte Carlo simulations. Consistent with previous studies on planar systems, we find that thermal fluctuations move phase boundaries, stabilizing phases of higher disorder...
November 7, 2018: Journal of Chemical Physics
Yuta Senzai
Anatomical observations, theoretical work and lesioning experiments have supported the idea that the CA3 in the hippocampus is important for encoding, storage and retrieval of memory while the dentate gyrus (DG) is important for the pattern separation of the incoming inputs from the entorhinal cortex. Study of the presumed function of the dentate gyrus in pattern separation has been hampered by the lack of reliable methods to identify different excitatory cell types in the DG. Recent papers have identified different cell types in the DG, in awake behaving animals, with more reliable methods...
November 5, 2018: Neuroscience Research
Dan Guo, Xu Zheng, Xiaohe Wang, Huizeng Li, Kaixuan Li, Zheng Li, Yanlin Song
Selective and deterministic assembly of particles is fundamentally significant for manufacturing functional devices. However, it is still a challenge to precisely and facilely manipulate particles of different sizes into different assembly patterns. Herein, a method is presented to achieve precise control over the formation of binary or ternary particle size-sorted assemblies. We investigate the assembly process of particles by capillary confinement and show that different size-sorted assemblies of multiple components can be realized by tuning the templated dewetting...
November 8, 2018: Angewandte Chemie
Lauren A Gonzales, Michael D Malinzak, Richard F Kay
OBJECTIVES: Recent evidence suggests that the amount of intraspecific variation in semicircular canal morphology may, itself, be evidence for varying levels of selection related to locomotor demands. To determine the extent of this phenomenon across taxa, we expand upon previous work by examining intraspecific variation in canal radii and canal orthogonality in a broad sample of strepsirrhine and platyrrhine primates. Patterns of interspecific variation are re-examined in light of intraspecific variation to better understand the resolution at which locomotion can be reconstructed from single individuals...
November 8, 2018: American Journal of Physical Anthropology
José Ignacio Santos, Iván Rivilla, Fernando P Cossio, Jon M Matxain, Marek Grzelczak, Shobeir K S Mazinani, Jesus M Ugalde, Vladimiro Mujica
NMR-based techniques are supposed to be incapable of distinguishing pure crystalline chemical enantiomers. However, through systematic studies of cross-polarization magic angle spinning (CP-MAS) NMR in ‎a series of aminoacids, we have found a rather unexpected behavior in the intensity pattern of optical isomers in hydrogen/nitrogen nuclear polarization transfer that would allow the use of CP NMR as a non-destructive enantioselective detection technique. In all molecules considered, the D isomer yields higher intensity than the L form, while the chemical shift for all nuclei involved remains unchanged...
November 8, 2018: ACS Nano
Seong Min Kim, Min Suk Lee, Jin Jeon, Dong Hyun Lee, Kisuk Yang, Seung-Woo Cho, Inbo Han, Hee Seok Yang
An innovative technique combining capillary force lithography and phase separation method in one step is applied to fabricate artificial nerve guidance conduit (NGC) for peripheral nerve regeneration. Biodegradable porous, patterned NGC (PP-NGC) using poly(lactic-co-glycolic acid) is fabricated. It has micro-grooves and microporosity on the inner surface to promote axonal outgrowth and to enhance permeability for nutrient exchange. In this study, it is confirmed that the inner surface of micro-grooves can modulate neurite orientation and length of mouse neural stem cell compared to porous flat NGC (PF-NGC) in vitro...
November 8, 2018: Macromolecular Bioscience
Lilla Makszin, Péter Kustán, Balázs Szirmay, Csilla Páger, Emerencia Mező, Krisztina I Kalács, Vera Pászthy, Erzsébet Györgyi, Ferenc Kilár, Andrea Ludány, Tamás Kőszegi
Perchloric acid (PCA) precipitation is a well-known method for the separation of heavily glycosylated proteins and for reducing the masking effect of major serum proteins. The aim of this study is to characterize PCA-soluble serum proteins in healthy individuals and in patients with systemic inflammatory diseases, such as Crohn's disease (CD) and sepsis. A PCA precipitation protocol was prepared and adapted to the analytical methods. After PCA treatment of the serum, the soluble proteins in the supernatants were analyzed by SDS-PAGE and by microchip gel electrophoresis (MGE)...
November 8, 2018: Electrophoresis
Patrick S R Davidson, Petar Vidjen, Sara Trincao-Batra, Charles A Collin
OBJECTIVES: Pattern separation in memory encoding entails creating and storing distinct, detailed representations to facilitate storage and retrieval. The Mnemonic Similarity Test (Stark, Yassa, Lacy, & Stark, 2013) has been used to argue that normal aging leads to pattern separation decline. We sought to replicate previous reports of age-related difficulty on this behavioral pattern separation estimate, and to examine its neuropsychological correlates, specifically long-term memory function, executive function, and visual perception...
November 8, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Y-P Chen, Y-Q Wang, J-W Lv, Y-Q Li, M L K Chua, Q-T Le, N Lee, A Dimitrios Colevas, T Seiwert, D N Hayes, N Riaz, J B Vermorken, B O'Sullivan, Q-M He, X-J Yang, L-L Tang, Y-P Mao, Y Sun, N Liu, J Ma
Background: Targeting the immune checkpoint pathway has demonstrated anti-tumor cytotoxicity in treatment-refractory head and neck squamous cell carcinoma (HNSC). To understand the molecular mechanisms underpinning its anti-tumor response, we characterized the immune landscape of HNSC by their tumor and stromal compartments to identify novel immune molecular subgroups. Patients and methods: A training cohort of 522 HNSC samples from the Cancer Genome Atlas profiled by RNA sequencing was analyzed...
November 8, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"