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Peggy Series

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https://www.readbyqxmd.com/read/28552030/shifting-visual-perspective-during-memory-retrieval-reduces-the-accuracy-of-subsequent-memories
#1
Petra Marcotti, Peggy L St Jacques
Memories for events can be retrieved from visual perspectives that were never experienced, reflecting the dynamic and reconstructive nature of memories. Characteristics of memories can be altered when shifting from an own eyes perspective, the way most events are initially experienced, to an observer perspective, in which one sees oneself in the memory. Moreover, recent evidence has linked these retrieval-related effects of visual perspective to subsequent changes in memories. Here we examine how shifting visual perspective influences the accuracy of subsequent memories for complex events encoded in the lab...
May 28, 2017: Memory
https://www.readbyqxmd.com/read/28414090/rituximab-treatment-circumvents-the-prognostic-impact-of-tumor-infiltrating-t-cells-in-follicular-lymphoma-patients
#2
Luc Xerri, Sarah Huet, Jeffrey M Venstrom, Edith Szafer-Glusman, Bettina Fabiani, Danielle Canioni, Catherine Chassagne-Clément, Peggy Dartigues-Cuilléres, Fréderic Charlotte, Camille Laurent, Benedicte Gelas-Dore, Christopher R Bolen, Elizabeth Punnoose, Reda Bouabdallah, Pauline Brice, Franck Morschhauser, Guillaume Cartron, Daniel Olive, Gilles Salles
Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor infiltrating lymphocytes (TIL) in follicular lymphoma (FL). In order to clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial were examined. IHC was quantified using automated image analysis in 417, 287, 418, 406, 379, and 369 patients for CD3, CD4, CD8, PD1, ICOS, and FOXP3; respectively. RNAseq analysis was used to quantify TIL-related mRNA transcripts from 148 patients...
April 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28328648/the-economic-and-clinical-impact-of-sustained-use-of-a-progressive-mobility-program-in-a-neuro-icu
#3
Jeannette M Hester, Peggy R Guin, Gale D Danek, Jaime R Thomas, William L Titsworth, Richard K Reed, Terrie Vasilopoulos, Brenda G Fahy
OBJECTIVE: To investigate a progressive mobility program in a neurocritical care population with the hypothesis that the benefits and outcomes of the program (e.g., decreased length of stay) would have a significant positive economic impact. DESIGN: Retrospective analysis of economic and clinical outcome data before, immediately following, and 2 years after implementation of the Progressive Upright Mobility Protocol Plus program (UF Health Shands Hospital, Gainesville, FL) involving a series of planned movements in a sequential manner with an additional six levels of rehabilitation in the neuro-ICU at UF Health Shands Hospital...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28316874/computational-drug-repositioning-using-continuous-self-controlled-case-series
#4
Zhaobin Kuang, James Thomson, Michael Caldwell, Peggy Peissig, Ron Stewart, David Page
Computational Drug Repositioning (CDR) is the task of discovering potential new indications for existing drugs by mining large-scale heterogeneous drug-related data sources. Leveraging the patient-level temporal ordering information between numeric physiological measurements and various drug prescriptions provided in Electronic Health Records (EHRs), we propose a Continuous Self-controlled Case Series (CSCCS) model for CDR. As an initial evaluation, we look for drugs that can control Fasting Blood Glucose (FBG) level in our experiments...
August 2016: KDD: Proceedings
https://www.readbyqxmd.com/read/28167920/modeling-trait-anxiety-from-computational-processes-to-personality
#5
REVIEW
James G Raymond, J Douglas Steele, Peggy Seriès
Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with reference to the behavior of individuals high in "trait" anxiety, which is a known vulnerability factor for the development of anxiety and mood disorders. However, it is not clear how this self-report measure relates to neural and behavioral processes captured by computational models...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27943159/conditioned-task-set-competition-neural-mechanisms-of-emotional-interference-in-depression
#6
Aleks Stolicyn, J Douglas Steele, Peggy Seriès
Depression has been associated with increased response times at the incongruent-, neutral-, and negative-word trials of the classical and emotional Stroop tasks (Epp et al., Clinical Psychology Review, 32, 316-328, 2012). Response-time slowdown effects at incongruent- and negative-word trials of the Stroop tasks were reported to correlate with depressive severity, indicating strong relevance of the effects to the symptomatology. This study proposes a novel integrative computational model of neural mechanisms of both the classical and emotional Stroop effects, drawing on the previous prominent theoretical explanations of performance at the classical Stroop task (Cohen, Dunbar, & McClelland, Psychological Review, 97, 332-361, 1990; Herd, Banich, & O'Reilly, Journal of Cognitive Neuroscience, 18, 22-32, 2006), and in addition suggesting that negative emotional words represent conditioned stimuli for future negative outcomes...
December 9, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/27770810/systematic-assessment-of-her2-neu-in-gynecologic-neoplasms-an-institutional-experience
#7
Jennifer S Woo, Sophia K Apple, Peggy S Sullivan, Jian-Yu Rao, Nora Ostrzega, Neda A Moatamed
BACKGROUND: HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti-HER2/neu treatment. METHODS: We systematically evaluated the HER2/neu reactions by immunohistochemistry and fluorescent in situ hybridization in malignant gynecologic neoplasms as experienced in our institution. RESULTS: The HER2/neu overexpression or amplification occurred in 8 % of the cancers of the gynecological organs in our series...
October 22, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27758822/mediastinal-gray-zone-lymphoma-clinico-pathological-characteristics-and-outcomes-of-99-patients-from-the-lymphoma-study-association
#8
Clémentine Sarkozy, Thierry Molina, Hervé Ghesquières, Anne-Sophie Michallet, Jehan Dupuis, Diane Damotte, Franck Morsschauser, Marie Parrens, Laurent Martin, Peggy Dartigues, Aspasia Stamatoullas, Pierre Hirsch, Bettina Fabiani, Krimo Bouabdallah, Maria Gomes da Silva, Marie Maerevoet, Camille Laurent, Bertrand Coiffier, Gilles Salles, Alexandra Traverse-Glehen
Mediastinal gray zone lymphoma, B-cell lymphomas with intermediate features between classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma, have not been well described in the literature. We report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis. Cases were defined as classical Hodgkin lymphoma-like morphology (64.6%) with primary mediastinal B-cell lymphoma immunophenotype, primary mediastinal B-cell lymphoma-like morphology (30...
January 2017: Haematologica
https://www.readbyqxmd.com/read/27746793/a-developmental-transcriptome-map-for-allotetraploid-arachis-hypogaea
#9
Josh Clevenger, Ye Chu, Brian Scheffler, Peggy Ozias-Akins
The advent of the genome sequences of Arachis duranensis and Arachis ipaensis has ushered in a new era for peanut genomics. With the goal of producing a gene atlas for cultivated peanut (Arachis hypogaea), 22 different tissue types and ontogenies that represent the full development of peanut were sequenced, including a complete reproductive series from flower to peg elongation and peg tip immersion in the soil to fully mature seed. Using a genome-guided assembly pipeline, a homeolog-specific transcriptome assembly for Arachis hypogaea was assembled and its accuracy was validated...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27689882/synthesis-and-evaluation-of-paclitaxel-loaded-gold-nanoparticles-for-tumor-targeted-drug-delivery
#10
Giulio F Paciotti, Jielu Zhao, Shugeng Cao, Peggy J Brodie, Lawrence Tamarkin, Marja Huhta, Lonnie D Myer, Jay Friedman, David G I Kingston
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
November 16, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27575007/an-investigation-into-the-immunomodulatory-activities-of-sutherlandia-frutescens-in-healthy-mice
#11
Wei Lei, Jimmy D Browning, Peggy A Eichen, William R Folk, Grace Y Sun, Dennis B Lubahn, Kevin L Fritsche
Sutherlandia frutescens is a medicinal plant that has been traditionally used in southern Africa for cancers, infections, and inflammatory conditions. We recently published experiments demonstrating that an aqueous extract of S. frutescens possessed potent immune-stimulatory activity. This work was carried out with murine macrophages, an immune cell type that plays a pivotal role in host defense from infection and in shaping host inflammatory and immune responses. Here, we conducted a series of follow-up experiments to explore the impact of consuming S...
2016: PloS One
https://www.readbyqxmd.com/read/27479061/official-american-thoracic-society-clinical-practice-guidelines-diagnostic-evaluation-of-infants-with-recurrent-or-persistent-wheezing
#12
Clement L Ren, Charles R Esther, Jason S Debley, Marianna Sockrider, Ozge Yilmaz, Nikhil Amin, Alia Bazzy-Asaad, Stephanie D Davis, Manuel Durand, Jeffrey M Ewig, Hasan Yuksel, Enrico Lombardi, Terry L Noah, Peggy Radford, Sarath Ranganathan, Alejandro Teper, Miles Weinberger, Jan Brozek, Kevin C Wilson
BACKGROUND: Infantile wheezing is a common problem, but there are no guidelines for the evaluation of infants with recurrent or persistent wheezing that is not relieved or prevented by standard therapies. METHODS: An American Thoracic Society-sanctioned guideline development committee selected clinical questions related to uncertainties or controversies in the diagnostic evaluation of wheezing infants. Members of the committee conducted pragmatic evidence syntheses, which followed the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach...
August 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27375528/anxiolytic-treatment-impairs-helping-behavior-in-rats
#13
Inbal Ben-Ami Bartal, Haozhe Shan, Nora M R Molasky, Teresa M Murray, Jasper Z Williams, Jean Decety, Peggy Mason
Despite decades of research with humans, the biological mechanisms that motivate an individual to help others remain poorly understood. In order to investigate the roots of pro-sociality in mammals, we established the helping behavior test, a paradigm in which rats are faced with a conspecific trapped in a restrainer that can only be opened from the outside. Over the course of repeated test sessions, rats exposed to a trapped cagemate learn to open the door to the restrainer, thereby helping the trapped rat to escape (Ben-Ami Bartal et al...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27325412/improving-breast-ultrasound-interpretation-in-uganda-using-a-condensed-breast-imaging-reporting-and-data-system
#14
John R Scheel, Sue Peacock, Jackson Orem, Samuel Bugeza, Zeridah Muyinda, Peggy L Porter, William C Wood, Robert L Comis, Constance D Lehman
RATIONALE AND OBJECTIVES: This study aimed to determine whether a 2-day educational course using a condensed Breast Imaging Reporting and Data System (condensed BI-RADS) improved the accuracy of Ugandan healthcare workers interpreting breast ultrasound. MATERIALS AND METHODS: The target audience of this intervention was Ugandan healthcare workers involved in performing, interpreting, or acting on the results of breast ultrasound. The educational course consisted of a pretest knowledge assessment, a series of lectures on breast imaging interpretation and standardized reporting using a condensed BI-RADS, and a posttest knowledge assessment...
October 2016: Academic Radiology
https://www.readbyqxmd.com/read/27175394/summer-anesthesiology-externship-demonstrating-the-ability-of-early-clinical-involvement-to-educate-and-increase-specialty-interest
#15
Kevin S Baker, Daniel Cormican, Peggy A Seidman
BACKGROUND: We describe the influence of a 6-week "Summer Anesthesiology Externship" featuring didactic, procedure, and simulation education on formation of medical students' specialty choice. METHODS: Eighteen months after externship completion, externs were sent a questionnaire with Likert scale agreement ratings of subspecialties/simulations and yes/no questions about student career interests before/after the program, stipend importance, and procedural skill performance during/after the program...
July 2012: Journal of Education in Perioperative Medicine: JEPM
https://www.readbyqxmd.com/read/27073233/microduplications-at-the-pseudoautosomal-shox-locus-in-autism-spectrum-disorders-and-related-neurodevelopmental-conditions
#16
Maria Tropeano, Deirdre Howley, Matthew J Gazzellone, C Ellie Wilson, Joo Wook Ahn, Dimitri J Stavropoulos, Clodagh M Murphy, Peggy S Eis, Eli Hatchwell, Richard J B Dobson, Dene Robertson, Muriel Holder, Melita Irving, Dragana Josifova, Annelise Nehammer, Mina Ryten, Debbie Spain, Mark Pitts, Jessica Bramham, Philip Asherson, Sarah Curran, Evangelos Vassos, Gerome Breen, Frances Flinter, Caroline Mackie Ogilvie, David A Collier, Stephen W Scherer, Grainne M McAlonan, Declan G Murphy
BACKGROUND: The pseudoautosomal short stature homeobox-containing (SHOX) gene encodes a homeodomain transcription factor involved in cell-cycle and growth regulation. SHOX/SHOX enhancers deletions cause short stature and skeletal abnormalities in a female-dominant fashion; duplications appear to be rare. Neurodevelopmental disorders (NDDs), such as autism spectrum disorders (ASDs), are complex disorders with high heritability and skewed sex ratio; several rare (<1% frequency) CNVs have been implicated in risk...
August 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27034010/molecular-classification-of-cancer-with-the-92-gene-assay-in-cytology-and-limited-tissue-samples
#17
Elena F Brachtel, Theresa N Operaña, Peggy S Sullivan, Sarah E Kerr, Karen A Cherkis, Brock E Schroeder, Sarah M Dry, Catherine A Schnabel
BACKGROUND: Detailed molecular evaluation of cytology and limited tissue samples is increasingly becoming the standard for cancer care. Reproducible and accurate diagnostic approaches with reduced demands on cellularity are an ongoing unmet need. This study evaluated the performance of a 92-gene assay for molecular diagnosis of tumor type/subtype in cytology and limited tissue samples. METHODS: Clinical validation of accuracy for the 92-gene assay in limited tissue samples such as cytology cell blocks, core biopsies and small excisions was conducted in a blinded multi-institutional study (N = 109, 48% metastatic, 53% grade II and III)...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/26978485/the-22q11-prodh-dgcr6-deletion-is-frequent-in-hyperprolinemic-subjects-but-is-not-a-strong-risk-factor-for-asd
#18
Anne Claire Richard, Anne Rovelet-Lecrux, Elsa Delaby, Camille Charbonnier, Bhooma Thiruvahindrapuram, Eli Hatchwell, Peggy S Eis, Alexandra Afenjar, Brigitte Gilbert Dussardier, Stephen W Scherer, Catalina Betancur, Dominique Campion
The proline dehydrogenase (PRODH) gene maps to 22q11.2 in the region deleted in the velo-cardio-facial syndrome (VCFS). A moderate to severe reduction (>50%) in PRODH activity resulting from recessive deletions and/or missense mutations has been shown to cause type 1 hyperprolinemia (HPI). Autistic features have been reported as a common clinical manifestation of HPI. Here we studied the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 gene in three case-control studies, one comprising HPI patients (n = 83), and the other two comprising autism spectrum disorder (ASD) patients (total of n = 2800), analyzed with high-resolution microarrays...
April 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26967774/a-prospective-time-series-quality-improvement-trial-of-a-standardized-analgesia-protocol-to-reduce-postoperative-pain-among-neurosurgery-patients
#19
W Lee Titsworth, Justine Abram, Peggy Guin, Mary A Herman, Jennifer West, Nicolle W Davis, Jennifer Bushwitz, Robert W Hurley, Christoph N Seubert
OBJECTIVE The inclusion of the pain management domain in the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey now ties patients' perceptions of pain and analgesia to financial reimbursement for inpatient stays. Therefore, the authors wanted to determine if a quality improvement initiative centered on a standardized analgesia protocol could significantly reduce postoperative pain among neurosurgery patients. METHODS The authors implemented a 10-month, prospective, interrupted time-series trial of a quality improvement initiative...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26781030/asgpr-mediated-uptake-of-multivalent-glycoconjugates-for-drug-delivery-in-hepatocytes
#20
Marie Monestier, Peggy Charbonnier, Christelle Gateau, Martine Cuillel, Faustine Robert, Colette Lebrun, Elisabeth Mintz, Olivier Renaudet, Pascale Delangle
Liver cells are an essential target for drug delivery in many diseases. The hepatocytes express the asialoglycoprotein receptor (ASGPR), which promotes specific uptake by means of N-acetylgalactosamine (GalNAc) recognition. In this work, we designed two different chemical architectures to treat Wilson's disease by intracellular copper chelation. Two glycoconjugates functionalized with three or four GalNAc units each were shown to enter hepatic cells and chelate copper. Here, we studied two series of compounds derived from these glycoconjugates to find key parameters for the targeting of human hepatocytes...
April 1, 2016: Chembiochem: a European Journal of Chemical Biology
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