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Peggy Series

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https://www.readbyqxmd.com/read/29903692/neurons-that-update-representations-of-the-future
#1
Peggy Seriès
A recent article shows that the brain automatically estimates the probabilities of possible future actions before it has even received all the information necessary to decide what to do next.
June 11, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29800053/olfactory-dysfunction-in-patients-with-cngb1-associated-retinitis-pigmentosa
#2
Peter Charbel Issa, Peggy Reuter, Laura Kühlewein, Johannes Birtel, Martin Gliem, Anke Tropitzsch, Katherine L Whitcroft, Hanno J Bolz, Kenji Ishihara, Robert E MacLaren, Susan M Downes, Akio Oishi, Eberhart Zrenner, Susanne Kohl, Thomas Hummel
Importance: Co-occurrence of retinitis pigmentosa (RP) and olfactory dysfunction may have a common genetic cause. Objective: To report olfactory function and the retinal phenotype in patients with biallelic mutations in CNGB1, a gene coding for a signal transduction channel subunit expressed in rod photoreceptors and olfactory sensory neurons. Design, Setting, and Participants: This case series was conducted from August 2015 through July 2017...
May 24, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29757142/autistic-traits-but-not-schizotypy-predict-increased-weighting-of-sensory-information-in-bayesian-visual-integration
#3
Povilas Karvelis, Aaron R Seitz, Stephen M Lawrie, Peggy Seriès
Recent theories propose that schizophrenia/schizotypy and autistic spectrum disorder are related to impairments in Bayesian inference i.e. how the brain integrates sensory information (likelihoods) with prior knowledge. However existing accounts fail to clarify: i) how proposed theories differ in accounts of ASD vs. schizophrenia and ii) whether the impairments result from weaker priors or enhanced likelihoods. Here, we directly address these issues by characterizing how 91 healthy participants, scored for autistic and schizotypal traits, implicitly learned and combined priors with sensory information...
May 14, 2018: ELife
https://www.readbyqxmd.com/read/29755826/pharmacovigilance-via-baseline-regularization-with-large-scale-longitudinal-observational-data
#4
Zhaobin Kuang, Peggy Peissig, Vítor Santos Costa, Richard Maclin, David Page
Several prominent public health hazards [29] that occurred at the beginning of this century due to adverse drug events (ADEs) have raised international awareness of governments and industries about pharmacovigilance (PhV) [6,7], the science and activities to monitor and prevent adverse events caused by pharmaceutical products after they are introduced to the market. A major data source for PhV is large-scale longitudinal observational databases (LODs) [6] such as electronic health records (EHRs) and medical insurance claim databases...
August 2017: KDD: Proceedings
https://www.readbyqxmd.com/read/29663171/prognostic-relevance-of-mutations-and-copy-number-alterations-assessed-with-targeted-next-generation-sequencing-in-idh-mutant-grade-ii-glioma
#5
Maarten M J Wijnenga, Pim J French, Hendrikus J Dubbink, Winand N M Dinjens, Peggy N Atmodimedjo, Johan M Kros, Ruth Fleischeuer, Clemens M F Dirven, Arnaud J P E Vincent, Martin J van den Bent
BACKGROUND: At current prognostication of low grade glioma remains suboptimal and might be improved with additional markers. These may guide treatment decisions, in particular on early adjuvant therapy versus wait and see after surgery. METHODS: We used a targeted Next-Generation Sequencing panel to assess mutational and copy number status of selected genes and chromosomes in a consecutive series of adult grade II supratentorial glioma, and assessed the impact of molecular markers of interest on overall survival...
April 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29652073/the-iron-regulatory-proteins-are-defective-in-repressing-translation-via-exogenous-5-iron-responsive-elements-despite-their-relative-abundance-in-leukemic-cellular-models
#6
Emmanuel Pourcelot, Marine Lénon, Peggy Charbonnier, Fiona Louis, Pascal Mossuz, Jean-Marc Moulis
In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor. The absolute concentrations of the components of this regulatory system in hematopoietic cells and the ability of the endogenous IRP to regulate exogenous IRE have been measured...
April 25, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29581060/performance-monitoring-integrated-reweighting-model-of-perceptual-learning
#7
Grigorios Sotiropoulos, Aaron R Seitz, Peggy Seriès
Perceptual learning (PL) has been traditionally thought of as highly specific to stimulus properties, task and retinotopic position. This view is being progressively challenged, with accumulating evidence that learning can generalize (transfer) across various parameters under certain conditions. For example, retinotopic specificity can be diminished when the proportion of easy to hard trials is high, such as when multiple short staircases, instead of a single long one, are used during training. To date, there is a paucity of mechanistic explanations of what conditions affect transfer of learning...
April 24, 2018: Vision Research
https://www.readbyqxmd.com/read/29491188/hiv-latency-in-isolated-patient-cd4-t-cells-may-be-due-to-blocks-in-hiv-transcriptional-elongation-completion-and-splicing
#8
Steven A Yukl, Philipp Kaiser, Peggy Kim, Sushama Telwatte, Sunil K Joshi, Mai Vu, Harry Lampiris, Joseph K Wong
Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection, but it is unclear what mechanisms govern latent HIV infection in vivo. To address this question, we developed a new panel of reverse transcription droplet digital polymerase chain reaction (RT-ddPCR) assays specific for different HIV transcripts that define distinct blocks to transcription. We applied this panel of assays to CD4+ T cells freshly isolated from HIV-infected patients on suppressive antiretroviral therapy (ART) to quantify the degree to which different mechanisms inhibit HIV transcription...
February 28, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29456494/the-influence-of-feedback-on-task-switching-performance-a-drift-diffusion-modeling-account
#9
Russell Cohen Hoffing, Povilas Karvelis, Samuel Rupprechter, Peggy Seriès, Aaron R Seitz
Task-switching is an important cognitive skill that facilitates our ability to choose appropriate behavior in a varied and changing environment. Task-switching training studies have sought to improve this ability by practicing switching between multiple tasks. However, an efficacious training paradigm has been difficult to develop in part due to findings that small differences in task parameters influence switching behavior in a non-trivial manner. Here, for the first time we employ the Drift Diffusion Model (DDM) to understand the influence of feedback on task-switching and investigate how drift diffusion parameters change over the course of task switch training...
2018: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29305224/snpitty-an-intuitive-web-application-for-interactive-b-allele-frequency-and-copy-number-visualization-of-next-generation-sequencing-data
#10
Job van Riet, Niels M G Krol, Peggy N Atmodimedjo, Erwin Brosens, Wilfred F J van IJcken, Maurice P H M Jansen, John W M Martens, Leendert H Looijenga, Guido Jenster, Hendrikus J Dubbink, Winand N M Dinjens, Harmen J G van de Werken
Exploration and visualization of next-generation sequencing data are crucial for clinical diagnostics. Software allowing simultaneous visualization of multiple regions of interest coupled with dynamic heuristic filtering of genetic aberrations is, however, lacking. Therefore, the authors developed the web application SNPitty that allows interactive visualization and interrogation of variant call format files by using B-allele frequencies of single-nucleotide polymorphisms and single-nucleotide variants, coverage metrics, and copy numbers analysis results...
March 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29161225/from-sexual-desire-discrepancies-to-desirable-sex-creating-the-optimal-connection
#11
Peggy J Kleinplatz, Nicolas Paradis, Maxime Charest, Shannon Lawless, Marlene Neufeld, Robert Neufeld, Danielle Pratt, A Dana Ménard, Bogdan Buduru, Lianne Rosen
Beginning in 2005, our team conducted a series of studies on optimal sexual experiences. We have applied our findings to develop a group therapy intervention for couples presenting with low sexual desire/frequency and sexual desire discrepancy. The goal was to improve the quality of erotic intimacy by focusing on such elements as being fully embodied during sex, increasing authenticity, trustworthiness, and vulnerability. Twenty-eight heterosexual individuals (14 couples) were seen in 16 hours of couples group therapy...
November 21, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28973495/identification-of-mutations-in-cell-free-circulating-tumor-dna-in-adrenocortical-carcinoma-a-case-series
#12
Sara G Creemers, Esther Korpershoek, Peggy N Atmodimedjo, Winand N M Dinjens, Peter M van Koetsveld, Richard A Feelders, Leo J Hofland
Context: The disease course of adrenocortical carcinoma (ACC) patients is heterogeneous. A marker for prognosis and treatment response would facilitate choices for diagnosis and therapy. In other cancer types, circulating cell-free tumor DNA predicted tumor dynamics. Case Descriptions: The present pilot study included six patients. Next-generation sequencing (NGS) showed mutations in three ACC cases. From these patients, blood was drawn before (1 to 2 weeks) and after surgery and cell-free circulating DNA (cfDNA) was isolated...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28867653/comprehensive-review-computational-modelling-of-schizophrenia
#13
REVIEW
Vincent Valton, Liana Romaniuk, J Douglas Steele, Stephen Lawrie, Peggy Seriès
Computational modelling has been used to address: (1) the variety of symptoms observed in schizophrenia using abstract models of behavior (e.g. Bayesian models - top-down descriptive models of psychopathology); (2) the causes of these symptoms using biologically realistic models involving abnormal neuromodulation and/or receptor imbalance (e.g. connectionist and neural networks - bottom-up realistic models of neural processes). These different levels of analysis have been used to answer different questions (i...
December 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28720026/models-of-reading-in-different-orthographies-an-introduction
#14
R Malatesha Joshi, Peggy McCardle
The authors provide a summary of the articles in the special series on reading development in different orthographies from various writing systems and scripts.
July 1, 2017: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/28675101/tympanoplasty-following-blast-injury
#15
Matthew Keller, Ryan Sload, Justin Wilson, Howard Greene, Peggy Han, Sean Wise
Objectives To assess outcomes following tympanoplasty for blast-induced tympanic membrane perforations in a military population. Study Design Case series with chart review. Setting Tertiary care medical centers. Subjects and Methods Military personnel (N = 254) undergoing tympanoplasty for blast-related tympanic membrane perforations sustained between April 2005 and July 2014 were identified from the Expeditionary Medical Encounter Database. Descriptive statistics were obtained regarding demographics, primary and revision surgery success rates, hearing status pre- and postsurgery, and frequency of ossicular reconstruction...
December 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28552030/shifting-visual-perspective-during-memory-retrieval-reduces-the-accuracy-of-subsequent-memories
#16
Petra Marcotti, Peggy L St Jacques
Memories for events can be retrieved from visual perspectives that were never experienced, reflecting the dynamic and reconstructive nature of memories. Characteristics of memories can be altered when shifting from an own eyes perspective, the way most events are initially experienced, to an observer perspective, in which one sees oneself in the memory. Moreover, recent evidence has linked these retrieval-related effects of visual perspective to subsequent changes in memories. Here we examine how shifting visual perspective influences the accuracy of subsequent memories for complex events encoded in the lab...
March 2018: Memory
https://www.readbyqxmd.com/read/28414090/rituximab-treatment-circumvents-the-prognostic-impact-of-tumor-infiltrating-t-cells-in-follicular-lymphoma-patients
#17
RANDOMIZED CONTROLLED TRIAL
Luc Xerri, Sarah Huet, Jeffrey M Venstrom, Edith Szafer-Glusman, Bettina Fabiani, Danielle Canioni, Catherine Chassagne-Clément, Peggy Dartigues-Cuilléres, Fréderic Charlotte, Camille Laurent, Benedicte Gelas-Dore, Christopher R Bolen, Elizabeth Punnoose, Reda Bouabdallah, Pauline Brice, Franck Morschhauser, Guillaume Cartron, Daniel Olive, Gilles Salles
Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantified using automated image analysis in 417, 287, 418, 406, 379, and 369 patients for CD3, CD4, CD8, PD1, ICOS, and FOXP3, respectively. RNAseq analysis was used to quantify TIL-related mRNA transcripts from 148 patients...
June 2017: Human Pathology
https://www.readbyqxmd.com/read/28328648/the-economic-and-clinical-impact-of-sustained-use-of-a-progressive-mobility-program-in-a-neuro-icu
#18
Jeannette M Hester, Peggy R Guin, Gale D Danek, Jaime R Thomas, William L Titsworth, Richard K Reed, Terrie Vasilopoulos, Brenda G Fahy
OBJECTIVE: To investigate a progressive mobility program in a neurocritical care population with the hypothesis that the benefits and outcomes of the program (e.g., decreased length of stay) would have a significant positive economic impact. DESIGN: Retrospective analysis of economic and clinical outcome data before, immediately following, and 2 years after implementation of the Progressive Upright Mobility Protocol Plus program (UF Health Shands Hospital, Gainesville, FL) involving a series of planned movements in a sequential manner with an additional six levels of rehabilitation in the neuro-ICU at UF Health Shands Hospital...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28316874/computational-drug-repositioning-using-continuous-self-controlled-case-series
#19
Zhaobin Kuang, James Thomson, Michael Caldwell, Peggy Peissig, Ron Stewart, David Page
Computational Drug Repositioning (CDR) is the task of discovering potential new indications for existing drugs by mining large-scale heterogeneous drug-related data sources. Leveraging the patient-level temporal ordering information between numeric physiological measurements and various drug prescriptions provided in Electronic Health Records (EHRs), we propose a Continuous Self-controlled Case Series (CSCCS) model for CDR. As an initial evaluation, we look for drugs that can control Fasting Blood Glucose (FBG) level in our experiments...
August 2016: KDD: Proceedings
https://www.readbyqxmd.com/read/28167920/modeling-trait-anxiety-from-computational-processes-to-personality
#20
REVIEW
James G Raymond, J Douglas Steele, Peggy Seriès
Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with reference to the behavior of individuals high in "trait" anxiety, which is a known vulnerability factor for the development of anxiety and mood disorders. However, it is not clear how this self-report measure relates to neural and behavioral processes captured by computational models...
2017: Frontiers in Psychiatry
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