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https://www.readbyqxmd.com/read/28213434/malaria-during-pregnancy
#1
Michal Fried, Patrick E Duffy
One hundred and twenty-five million women in malaria-endemic areas become pregnant each year (see Dellicour et al. PLoS Med7: e1000221 [2010]) and require protection from infection to avoid disease and death for themselves and their offspring. Chloroquine prophylaxis was once a safe approach to prevention but has been abandoned because of drug-resistant parasites, and intermittent presumptive treatment with sulfadoxine-pyrimethamine, which is currently used to protect pregnant women throughout Africa, is rapidly losing its benefits for the same reason...
February 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28211618/a-comparison-between-lynch-syndrome-and-sporadic-colorectal-cancer-survivors-satisfaction-with-their-healthcare-providers
#2
Allison M Burton-Chase, Wendy M Parker, Katrina M Polivka, Ellen R Gritz, Christopher I Amos, Karen H Lu, Patrick M Lynch, Miguel A Rodriguez-Bigas, Y Nancy You, Susan K Peterson
This study evaluated provider satisfaction in a sample of colorectal cancer (CRC) survivors with and without Lynch syndrome (LS). Participants were case-case-matched CRC survivors with (n = 75) or without (n = 75) LS (mean age of 55; range: 27-93). Participants completed a mailed questionnaire assessing demographics, clinical characteristics, healthcare utilization, psychosocial variables, and provider satisfaction. LS CRC survivors reported lower provider satisfaction scores on three subscales of the Primary Care Assessment Survey: communication (78...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28210388/topical-treatment-for-onychomycosis-is-it-more-effective-than-the-clinical-data-suggests
#3
REVIEW
Boni E Elewski, Tracey C Vlahovic, Andrew Korotzer
Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28209746/a-phase-ii-randomized-trial-go27827-of-first-line-folfox-plus-bevacizumab-with-or-without-the-met-inhibitor-onartuzumab-in-patients-with-metastatic-colorectal-cancer
#4
Johanna C Bendell, Howard Hochster, Lowell L Hart, Irfan Firdaus, Joseph R Mace, Joshua J McFarlane, Mark Kozloff, Daniel Catenacci, Jessie J Hsu, Stephen P Hack, David S Shames, See-Chun Phan, Hartmut Koeppen, Allen L Cohn
BACKGROUND: Dysregulated hepatocyte growth factor/mesenchymal-epithelial transition (MET) signaling is associated with poor prognosis and resistance to vascular endothelial growth factor inhibition in metastatic colorectal cancer (mCRC). We report outcomes from a double-blind, multicenter phase II trial of the MET inhibitor onartuzumab in combination with mFOLFOX-6 and bevacizumab for mCRC (GO27827; NCT01418222). MATERIALS AND METHODS: Patients were randomized 1:1 to receive onartuzumab (10 mg/kg intravenously [IV]) or placebo plus mFOLFOX-6 and bevacizumab (5 mg/kg IV)...
February 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28209702/primary-care-specialty-career-choice-among-canadian-medical-students-understanding-the-factors-that-influence-their-decisions
#5
Heather Ann Osborn, Jordan T Glicksman, Michael G Brandt, Philip C Doyle, Kevin Fung
OBJECTIVE: To identify which factors influence medical students' decision to choose a career in family medicine and pediatrics, and which factors influence their decision to choose careers in non-front-line specialties. DESIGN: Survey that was created based on a comprehensive literature review to determine which factors are considered important when choosing practice specialty. SETTING: Ontario medical school. PARTICIPANTS: An open cohort of medical students in the graduating classes of 2008 to 2011 (inclusive)...
February 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28202320/the-women-s-empower-survey-identifying-women-s-perceptions-on-vulvar-and-vaginal-atrophy-and-its-treatment
#6
Sheryl A Kingsberg, Michael Krychman, Shelli Graham, Brian Bernick, Sebastian Mirkin
INTRODUCTION: Vulvar and vaginal atrophy (VVA) affects up to two thirds of postmenopausal women, but most symptomatic women do not receive prescription therapy. AIM: To evaluate postmenopausal women's perceptions of VVA and treatment options for symptoms in the Women's EMPOWER survey. METHODS: The Rose Research firm conducted an internet survey of female consumers provided by Lightspeed Global Market Insite. Women at least 45 years of age who reported symptoms of VVA and residing in the United States were recruited...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28202097/independent-prescriber-physiotherapist-led-balance-clinic-the-southport-and-ormskirk-pathway
#7
L Burrows, T H Lesser, A V Kasbekar, N Roland, M Billing
OBJECTIVE: To report the introduction and impact of non-medical prescribing, initiated to improve patient pathways for those presenting with dizziness and balance disorders. METHODS: The Southport and Ormskirk physiotherapy-led vestibular clinic sees and treats all patients with dizziness and balance disorders referred to the ENT department. Letters are triaged by an audiologist, who also performs an otological examination and hearing test; this is followed by an assessment with the independent prescriber physiotherapist...
February 16, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28196182/what-surgeons-need-to-know-about-gender-confirmation-surgery-when-providing-care-for-transgender-individuals-a-review
#8
Jens U Berli, Gail Knudson, Lin Fraser, Vin Tangpricha, Randi Ettner, Frederic M Ettner, Joshua D Safer, Julie Graham, Stan Monstrey, Loren Schechter
Importance: In 2014, the US Department of Health and Human Services decided that its 1981 exclusion of transsexual surgical treatments from Medicare coverage was based on outdated, incomplete, and biased science and did not reflect current evidence or standards of care, and the exclusion was therefore lifted. As a direct result of this decision, surgeons nationwide are seeing an increase in consultations for surgical therapy to help transgender and gender-nonconforming individuals. Although some clinicians may have the technical training for such surgical procedures, in many cases, they may not have a full understanding of the complex and comprehensive care required to provide optimal health care for transgender individuals...
February 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28194835/mindfulness-based-cognitive-therapy-as-an-augmentation-treatment-for-obsessive-compulsive-disorder
#9
Brenda L Key, Karen Rowa, Peter Bieling, Randi McCabe, Elizabeth J Pawluk
: A significant number of obsessive-compulsive disorder (OCD) patients continue to experience symptoms that interfere with their functioning following cognitive behavioural therapy (CBT). Providing an additional augmentation treatment following CBT could help reduce these residual symptoms. Mindfulness interventions that facilitate less reactivity to thoughts and feelings may be helpful for patients suffering from residual OCD symptoms. The purpose of the current randomized waitlist control trial was to evaluate the feasibility and impact of providing an 8-week mindfulness-based cognitive therapy (MBCT) intervention following completion of a CBT intervention to OCD patients who continued to suffer from significant symptoms...
February 13, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28188364/a-survey-of-pulmonary-arteriovenous-malformation-screening-management-and-follow-up-in-hereditary-hemorrhagic-telangiectasia-centers-of-excellence
#10
Jeffrey Forris Beecham Chick, Shilpa N Reddy, Reed E Pyeritz, Scott O Trerotola
PURPOSE: To determine current practice regarding screening, management, and follow-up of pulmonary arteriovenous malformations (PAVMs), particularly those with feeding arteries <3 mm in diameter, in those patients with hereditary hemorrhagic telangiectasia (HHT) at HHT Centers of Excellence. MATERIALS AND METHODS: A 32-question survey focusing on PAVM screening, management, and follow-up was sent to 147 participants at HHT Centers worldwide. RESULTS: Thirty-three responses were received (22%); 60% from interventional radiologists and 20% from pulmonologists; 67% from the USA, 21% European, and 6% Asian...
February 10, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28186938/an-online-questionnaire-survey-of-uk-general-practitioners-knowledge-and-management-of-familial-hypercholesterolaemia
#11
See Kwok, Jing Pang, Safwaan Adam, Gerald F Watts, Handrean Soran
OBJECTIVE: Early diagnosis and treatment of heterozygous familial hypercholesterolaemia (HeFH) is known to be associated with reduced mortality from premature coronary artery disease, but HeFH remains underdiagnosed. This survey aims to determine knowledge and current management of HeFH in general practice. SETTING: An online questionnaire was administered to general practitioners' (GPs') in the North West of England to assess their knowledge and management of HeFH...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28181446/-insane-criminals-and-the-criminally-insane-criminal-asylums-in-norway-1895-1940
#12
Hilde Dahl
This article looks into the establishment and development of two criminal asylums in Norway. Influenced by international psychiatry and a European reorientation of penal law, the country chose to institutionalize insane criminals and criminally insane in separate asylums. Norway's first criminal asylum was opened in 1895, and a second in 1923, both in Trondheim. Both asylums quickly filled up with patients who often stayed for many years, and some for their entire lives. The official aim of these asylums was to confine and treat dangerous and disruptive lunatics...
February 1, 2017: History of Psychiatry
https://www.readbyqxmd.com/read/28178876/designing-fecal-microbiota-transplant-trials-that-account-for-differences-in-donor-stool-efficacy
#13
Scott W Olesen, Thomas Gurry, Eric J Alm
Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation's success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for other conditions like inflammatory bowel disease, obesity, diabetes, and Parkinson's disease. Results from clinical trials that use fecal microbiota transplantation to treat inflammatory bowel disease suggest that, for at least one condition beyond C...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28178695/german-guidelines-on-screening-diagnosis-and-treatment-of-alcohol-use-disorders
#14
Karl Mann, Anil Batra, Mira Fauth-Bühler, Eva Hoch
Evidence-based strategies for screening, diagnosing and treating alcohol use disorders (AUD) are instrumental in the early and better management of individuals at risk for or suffering from AUD. However, existing guidelines vary and may be biased by conflicts of interests. Unbiased recommendations can be achieved only if sufficient detail is provided on the composition and representativeness of author groups, methodological rigor, handling of potential conflicts of interest and financing. This paper presents the first evidence-based guidelines for AUD from German-speaking countries...
February 9, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28169938/percutaneous-or-open-reduction-of-closed-tibial-shaft-fractures-during-intramedullary-nailing-does-not-increase-wound-complications-infection-or-nonunion-rates
#15
Darryl A Auston, Jordan Meiss, Rafael Serrano, Thomas Sellers, Gregory Carlson, Timothy Hoggard, Michael Beebe, Jonathan Quade, David Watson, R Bruce Simpson, Brian Kistler, Anjan Shah, Roy Sanders, Hassan Mir
OBJECTIVE: To compare the incidence of complications (wound, infection, nonunion) among those patients treated with closed, percutaneous, and open intramedullary nailing for closed tibial shaft fractures. DESIGN: Retrospective Review. SETTING: Multiple trauma centers. PATIENTS: Skeletally mature patients with closed tibia fractures amenable to treatment with an intramedullary device. INTERVENTION: Intramedullary fixation with closed, percutaneous, or open reduction...
December 26, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28166481/the-benefits-risks-and-costs-of-privacy-patient-preferences-and-willingness-to-pay
#16
David E Trachtenbarg, Carl Asche, Shweta Ramsahai, Joy Duling, Jinma Ren
OBJECTIVE: Multiple surveys show patients want medical privacy, however, there are costs to maintain privacy. There are also risks if information is not shared. A review of previous surveys found most surveys asked questions about patient's privacy concerns and willingness to share their medical information. We found only one study that asked about sharing medical information for better care and no survey that asked patients about the risk, cost or comparison between medical privacy and privacy in other areas...
February 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28166170/superior-outcomes-after-operative-fixation-of-patella-fractures-using-a-novel-plating-technique-a-prospective-cohort-study
#17
Dean G Lorich, Peter D Fabricant, Gina Sauro, Lionel E Lazaro, Ryan R Thacher, Matthew R Garner, Stephen J Warner
OBJECTIVE: The purpose of this prospective cohort study was to determine if a new patella fracture fixation construct resulted in improved outcomes compared to traditional tension band techniques. DESIGN: Comparative cohort study. SETTING: Academic level I trauma center. PATIENTS/PARTICIPANTS: Patients with isolated, unilateral patellar fractures were enrolled prospectively. From 2012-2014, 33 patients underwent fixation with a novel plate construct that spans half of the patella circumference laterally and provides multiplanar fixation through a low profile plate...
January 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28165679/is-violence-senseless-not-according-to-science-let-s-make-sense-of-it-and-treat-it-like-a-disease
#18
Gary Slutkin
In many cities across the United States, we see a familiar scene unfold virtually every week- end - dozens of youth between the ages of 15 and 24, most of whom are black or Hispanic, are injured or killed in major cities including Baltimore, New York, Los Angeles, Chicago, St. Louis, New Orleans and Detroit. Outcries spread through neighborhoods and the nation; most are focused on the "senseless violence."
July 2016: Health Progress
https://www.readbyqxmd.com/read/28163990/authors-response-on-schick-et-al-2017-an-experiment-of-the-impact-of-a-neonicotinoid-pesticide-on-honey-bees-the-value-of-a-formal-analysis-of-the-data-environ-sci-eur-2017
#19
EDITORIAL
Peter Campbell, Mike Coulson, Keith Ward
Whilst a formal statistical analysis of any experimental data is always preferable in principle, in the case of Pilling et al. (PLoS ONE 8:e77193, 2013), it is hard to see how the results of any formal analysis-including those provided by Schick et al.-could be considered reliable. Regardless of the issue of statistical analysis, there was a wealth of valuable and novel biological and chemical residue data generated under field conditions of use in Pilling et al., which when taken into consideration alongside other relevant available published data and information (i...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28160853/identification-of-acetylshikonin-as-the-novel-cyp2j2-inhibitor-with-anti-cancer-activity-in-hepg2-cells
#20
See-Hyoung Park, Nguyen Minh Phuc, Jongsung Lee, Zhexue Wu, Jieun Kim, Hyunkyoung Kim, Nam Doo Kim, Taeho Lee, Kyung-Sik Song, Kwang-Hyeon Liu
BACKGROUND: Acetylshikonin is one of the biologically active compounds derived from the root of Lithospermum erythrorhizon, a medicinal plant with anti-cancer and anti-inflammation activity. Although there have been a few previous reports demonstrating that acetylshikonin exerts anti-cancer activity in vitro and in vivo, it is still not clear what is the exact molecular target protein of acetylshikonin in cancer cells. PURPOSE: The purpose of this study is to evaluate the inhibitory effect of acetylshikonin against CYP2J2 enzyme which is predominantly expressed in human tumor tissues and carcinoma cell lines...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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