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Alka Singh, Rajeshwar Nath Srivastava, Ashok Agrahari, Suruchi Singh, Saloni Raj, Tanushri Chatterji, Abbas Ali Mahdi, Ravindra Kumar Garg, Raja Roy
BACKGROUND: Acute Spinal Cord Injury (ASCI) is still having substantial morbidity and mortality despite of advanced therapeutics. Major obstacles are paucity of monitoring tools or biomarkers for severity determination, recovery and prognostication. A prospective case control pilot study with serum 1 H NMR spectroscopic metabolic profiling was carried out to evaluate metabolites perturbations and its relationship with recovery and to see role of stem cells in facilitating neurological recovery...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Han Gyeol Park, Tae Jung Kim, Farman Ullah, Van Long Le, Hoang Tung Nguyen, Yong Soo Kim, Young Dong Kim
The dielectric function [Formula: see text] of monolayer molybdenum diselenide (MoSe 2 ) is obtained and analyzed at temperatures from 31 to 300 K and at energies from 0.74 to 6.42 eV. The sample is a large-area, partially discontinuous monolayer (submonolayer) film of MoSe 2 grown on a sapphire substrate by selenization of pulsed laser deposited MoO 3 film. Morphological and optical characterizations verified the excellent quality of the film. The MoSe 2 data were analyzed using the effective medium approximation, which treats the film and bare substrate regions as a single layer...
February 16, 2018: Scientific Reports
Dool-Ri Oh, Yujin Kim, Eun-Jin Choi, Myung-A Jung, Kyo-Nyeo Oh, Ji-Ae Hong, Donghyuck Bae, Kwangsu Kim, Huwon Kang, Jaeyong Kim, Young Ran Kim, Seung Sik Cho, Chul-Young Choi
The fruit of Vaccinium bracteatum Thunb. (VBF) is commonly known as the oriental blueberry in Korea. The aim of this study was to evaluate the antidepressant-like effects of water VBF extract (VBFW) in a mouse model of chronic restraint stress (CRS) and to identify the underlying mechanisms of its action. The behavioral effects of VBFW were assessed in the forced swim test (FST) and open field test (OFT). The levels of serum corticosterone (CORT), brain monoamines, in addition to the extracellular signal-regulated kinases (ERKs)/protein kinase B (Akt) signaling pathway were evaluated...
February 14, 2018: American Journal of Chinese Medicine
Marian J Surma, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: Measurements of GFR may be performed with a slope/intercept method (S/I), using only two blood samples taken in strictly defined time points. The aim of the study was to modify this method in order to extend time intervals suitable for blood sampling. Modification was based on a variation of a Russel et al. model parameter, selection of time intervals suitable for blood sampling and assessment of uncertainty of calculated results. MATERIAL AND METHODS: Archived values of GFR measurements of 169 patients with different renal function, from 5...
2018: Nuclear Medicine Review. Central & Eastern Europe
Luis E Tollinche, Gloria Yang, Kay-See Tan, Ruth Borchardt
BACKGROUND: The American Society of Anesthesiologists (ASA) physical status is a universal classification system that helps clinicians to categorize their patients preoperatively. However, there is a lack of both inter-rater and intra-rater reliability among clinicians for the ASA physical status classification. Our study focuses on testing these reliabilities within pediatric anesthesia providers in the cancer setting. METHODS: In our retrospective observational study, a total of 1177 anesthesia records were reviewed...
February 13, 2018: Journal of Anesthesia
Tom B Mole, Pieter Mackeith
Postoperative neuropathic pain exacerbated by movement is poorly understood and difficult to treat but a relatively common complication of surgical procedures such as endoscopic thoracic sympathectomy. Here, we describe a case of unexpected, immediate, complete and sustained remission of postoperative intercostal neuralgia after the patient engaged in an open-water swim in markedly cold conditions. Though an incidental chance association is possible, the clear temporal proximity linking the swim with pain remission makes a causal relationship possible...
February 12, 2018: BMJ Case Reports
A Nascimento, E Villalobos-Pinto
INTRODUCTION: Infantile-onset Pompe disease is a kind of glycogenosis resulting from a deficit of the enzyme acid alpha-glucosidase. Before specific enzyme replacement therapy (ERT) became available, the classic form was fatal during the first two years of life. ERT increases survival and improves cardiac, respiratory and motor functioning. CASE REPORTS: Case 1: 2-month-old infant with predominantly axial hypotonia who required the use of a nasogastric tube as a result of difficulties in sucking and swallowing...
February 16, 2018: Revista de Neurologia
Mangesh I Chaudhari, Ajay Muralidharan, Lawrence R Pratt, Susan B Rempe
Progress in understanding liquid ethylene carbonate (EC) and propylene carbonate (PC) on the basis of molecular simulation, emphasizing simple models of interatomic forces, is reviewed. Results on the bulk liquids are examined from the perspective of anticipated applications to materials for electrical energy storage devices. Preliminary results on electrochemical double-layer capacitors based on carbon nanotube forests and on model solid-electrolyte interphase (SEI) layers of lithium ion batteries are considered as examples...
February 12, 2018: Topics in Current Chemistry (Journal)
Woogyeong Kim, Dahae Lim, Jinju Kim
[Formula: see text]-coumaric acid ([Formula: see text]-CA) is a common compound found in medicinal herbs, including Bambusae Caulis in Taeniam (BC). It has been used to treat various diseases in China and Korea. Our previous study demonstrated that BC inhibits pulmonary and intestinal inflammation. In the present study, we used cigarette smoke (CS) to induce lung inflammation in vivo, and investigated the anti-inflammatory effects of [Formula: see text]-CA on CS-induced inflammatory mice model. Mice were treated with BC and [Formula: see text]-CA via oral injection 2[Formula: see text]h before CS exposure...
February 12, 2018: American Journal of Chinese Medicine
Cory Collinge, Basem Attum, Paul Tornetta, William Obremskey, Jaimo Ahn, Gudrun Mirick, Andrew Schmidt, Clay Spitler, Chad Coles, Peter Krause
OBJECTIVES: The goal of this study was to describe current opinions of orthopedic trauma experts regarding acute compartment syndrome (ACS). DESIGN: Web-based survey SETTING:: N/A PARTICIPANTS:: Active Orthopedic Trauma Association (OTA) members METHODS:: A 25 item web-based questionnaire was advertised to active members of the OTA. Using a cross-sectional survey study design, we evaluated the perceived importance of ACS, as well as preferences in diagnosis and treatment...
January 24, 2018: Journal of Orthopaedic Trauma
Hitoshi Suzuki, Angela Chang, Hiroto Kumagae, Yuki Shimizu, Akinori Sakai, Soshi Uchida
Shoulder arthroscopy is a promising tool for assessing and treating patients with a rotator cuff tear. Arthroscopic rotator cuff repair with suture anchor fixation such as the single-row, double-row, and suture bridge technique are popular procedures that can provide excellent clinical outcomes. On the other hand, longitudinal midsubstance, U-shape, or L-shape tears may benefit more from a side-to-side/margin convergence technique. Despite following the standard side-to-side/margin convergence technique, we continue to see disruption at the site of side-to-side suture margin even with strong sutures...
October 2017: Arthroscopy Techniques
Uri Hochberg, Jordi Perez, Manuel Borod
Cancer pain is a multi-dimensional experience, varies from person to person both physically and psycho-socially, and impacts all aspects of the patients' quality of life. Majority of patients with an advanced or metastatic cancer will experience pain. It is estimated that as many as half of cancer patients are under-treated and as many as 20% experience pain refractory to the conventional WHO ladder of pain management. The McGill University Health Centre (MUHC) Cancer Pain Clinic (CPC) was created to meet the needs of those patients with a diagnosis of cancer whose pain had become a main symptom and those who failed to respond to conventional treatment...
February 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Laura Milena Múnera Restrepo, Lucia Uribe Restrepo, Carlos Enrique Yepes Delgado
OBJECTIVE: To determine the perception that some general clinical practitioners have about depressive syndrome in a region of Colombia. METHODOLOGY: The qualitative approach was established as a basis for this study using grounded theory for the description, analysis, and interpretation of data collected in 20 semi-structured interviews aimed at general medical practitioners who had treated patients with depressive syndrome in their clinical practice. RESULTS: Throughout the interviews, some essential elements are highlighted such as: "seeing beyond a body," where the interest of the physician is reflected by individualising each patient case because regardless of having the same disease, knowing that not all can be addressed or treated equally...
January 2018: Revista Colombiana de Psiquiatría
Ning Wang, An-Qi Zheng, Xun Liu, Junjie Chen, Ting Yang, Ming-Li Chen, Jian-Hua Wang
A novel approach for the preparation of dual-functional carbon dots, i.e., nitrogen and chloride doped carbon dots, shortly as N/Cl-CDs, is developed with the assistance of a choline chloride-glycerine deep eutectic solvent (DES). The carbon source is provided by urea and the DES serves as a solvent for controlling the preparation of CDs in the absence of water. The dual-element doped carbon dots are oxygen-rich with hydroxyl and amine groups. They exhibit an average particle size of ca. 3.88 nm, and give rise to strong and pH-sensitive fluorescent emission at λex/λem=340/430 nm with a quantum yield of 16...
February 9, 2018: ACS Applied Materials & Interfaces
Asif Ahmed, Joshua Boateng
AIM: Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa...
February 1, 2018: Therapeutic Delivery
Peng Xiang, Yun Fu, Shou-Hui Xu
OBJECTIVE: To explore clinical characteristics of 4 patients with knee discoid medial meniscus under arthroscopic. METHODS: From April 2012 to May 2015, 4 patients(4 knees) with knee discoid medial meniscus were treated with arthroscopic, including 1 male and 3 females, aged from 7 to 56 years old with an average of 26 years old. All patients were performed discoid meniscus plasty under arthroscopic. Postoperative symptoms and signs were observed, and clinical effects were evaluated by Lysholm knee scores...
June 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Tao Jiang, Meng Qiao, Chao Zhao, Xuefei Li, Guanghui Gao, Chunxia Su, Shengxiang Ren, Caicun Zhou
BACKGROUND: To investigate the association between pretreatment blood neutrophil-to-lymphocyte ratio (NLR) and clinical outcomes for advanced-stage cancer patients treated with immunotherapy. METHODS: We conducted a comprehensive literature search to assess the relationship between pretreatment blood NLR and overall survival (OS) or progression-free survival (PFS) in advanced-stage cancer patients treated with immunotherapy. Published data including hazard ratios (HRs) and related 95% confidence interval (CI) were extracted...
February 8, 2018: Cancer Immunology, Immunotherapy: CII
Anna-Janina Stephan, Eva Kovacs, Amanda Phillips, Jörg Schelling, Susanne Marlene Ulrich, Eva Grill
BACKGROUND: Although the management of patients presenting with vertigo and dizziness in primary care has been reported to be inefficient, little is known about the primary care providers' (PCPs) perspectives, needs, and attitudes regarding vertigo management. The objective of this study was to understand which challenges and barriers PCPs see when diagnosing and treating patients presenting with vertigo or dizziness. Specifically, we wanted to identify facilitators and barriers of successful guideline implementation in order to inform the development of targeted interventions...
February 8, 2018: Implementation Science: IS
Bikram K Paul, Chukwuemeka Ihemelandu, Paul H Sugarbaker
BACKGROUND: The prior surgical score estimates the extent of previous surgical intervention by quantitating surgical dissection within 9 abdominopelvic regions. OBJECTIVE: Our aim was to analyze the prognostic significance of the prior surgical score in our cohort of patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of a colorectal origin. DESIGN: This was a retrospective analysis of a prospectively maintained database for all patients treated for peritoneal carcinomatosis of a colorectal origin...
March 2018: Diseases of the Colon and Rectum
Nancy N Baxter, Hadas D Fischer, Devon P Richardson, David R Urbach, Chaim M Bell, Paula Rochon, Anthony Brade, Craig C Earle
BACKGROUND: Patients receiving Bevacizumab, a vascular endothelial growth factor inhibitor used to treat metastatic colorectal cancer, may be at greater risk of complications after colorectal surgery because of impaired healing. OBJECTIVE: The purpose of this study was to describe population-based rates of complications of colorectal surgery after Bevacizumab treatment and evaluate the relationship between time since last treatment and risk of complications. DESIGN: This was a population-based retrospective cohort study using administrative and cancer registry data...
March 2018: Diseases of the Colon and Rectum
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