keyword
MENU ▼
Read by QxMD icon Read
search

Sleep fragmentation

keyword
https://www.readbyqxmd.com/read/29337603/an-integrative-review-of-nonpharmacological-interventions-to-improve-sleep-among-adults-with-advanced-serious-illness
#1
Elizabeth Capezuti, Rana Sagha Zadeh, Nicole Woody, Aleksa Basara, Ana C Krieger
BACKGROUND: Sleep fragmentation is common among those with advanced serious illness. Nonpharmacological interventions to improve sleep have few, if any, adverse effects and are often underutilized in these settings. OBJECTIVE: We aimed to summarize the literature related to nonpharmacological interventions to improve sleep among adults with advanced serious illness. METHODS: We systematically searched six electronic databases for literature reporting sleep outcomes associated with nonpharmacological interventions that included participants with advanced serious illness during the period of 1996-2016...
January 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29303049/conducting-joint-interviews-with-couples-ethical-and-methodological-challenges
#2
Dana Zarhin
Scholars have recently begun to discuss joint interviewing from a methodological perspective, generally presenting a favorable view of this mode of interviewing. In the present article, the author draws on her experiences with interviewing obstructive sleep apnea patients and their partners to shed further light on the methodological and ethical challenges of joint interviews. Specifically, it is shown that joint interviews may become a site in which one partner silences the other and enacts symbolic violence, with the interviewer as unwilling abettor, or alternatively may facilitate passivity...
January 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29286538/effect-of-gabapentin-on-sleep-and-event-related-oscillations-eros-in-rats-exposed-to-chronic-intermittent-ethanol-vapor-and-protracted-withdrawal
#3
Manuel Sanchez-Alavez, Derek N Wills, Leslie Amodeo, Cindy L Ehlers
Disturbances in sleep architecture, especially reductions in slow wave sleep (SWS), are symptoms commonly observed in individuals with alcohol use disorders (AUDs). Recent clinical trials have demonstrated that the anticonvulsant and analgesic drug Gabapentin may have therapeutic value in normalizing sleep quality in recovering alcoholics. However, the brain mechanisms underlying this improvement in sleep following Gabapentin treatment remain unknown METHODS: In the present study, adult Wistar rats were exposed to 8 weeks of chronic intermittent ethanol vapor (CIE) (blood ethanol concentrations averaged 128...
December 29, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29247296/decrease-of-perforin-positive-cd3-%C3%AE-%C3%AE-t-cells-in-patients-with-obstructive-sleep-disordered-breathing
#4
Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
INTRODUCTION: Sleep related breathing disorders (SRBD) cause sleep fragmentation, intermittent hypoxia or a combination of both leading to homeostasis perturbations, including in the immune system. We investigated whether SRBD patients with or without intermittent hypoxia show substantial differences in perforin and granzyme-B positive peripheral blood lymphocytes. METHODS: A total of 87 subjects were included and distributed as follows: 24 controls (C), 19 patients with respiratory effort related arousals due to increased upper airway resistance (UAR) without hypoxic events, 24 obese patients with obstructive sleep apnea (OSA) (oOSA), and 20 without obesity (noOSA)...
December 15, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29234278/effects-of-social-defeat-stress-on-sleep-in-mice
#5
Fiona Henderson, Vincent Vialou, Salah El Mestikawy, Véronique Fabre
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance states in C57Bl/6J male mice. Social behavior was assessed to identify susceptible mice, i.e., mice that develop long-lasting social avoidance, and unsusceptible mice...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29220862/a-descriptive-analysis-of-sleep-and-wakefulness-states-during-maternal-behaviors-in-postpartum-rats
#6
L Benedetto, M Rivas, M Pereira, A Ferreira, P Torterolo
Mother rats spend most of their time nursing their litter during the early stages of the postpartum period, only occasionally leaving the nest. The suckling stimulus from the pups elicits the adoption of nursing postures, during which milk ejection occurs, an event associated with the occurrence of non-REM (NREM) sleep in the rat. Despite this evidence, the characteristics of sleep during different nursing postures along the postpartum period remain unknown. The present study aims to describe the sleep pattern of mother rats while nursing, hovering over their pups and when being away from the pups...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29208538/sleep-related-painful-erections-a-meta-analysis-on-the-pathophysiology-and-risks-and-benefits-of-medical-treatments
#7
REVIEW
Sanne Vreugdenhil, Alida Cornelia Weidenaar, Igle Jan de Jong, Mels Frank van Driel
BACKGROUND: Patients with sleep-related painful erections (SRPEs) have frequent awakenings from deep penile pain during nocturnal erections. This results in severe sleep deprivation. AIM: To review the current literature on SRPEs and discuss the pathophysiologic theories and risks and benefits of medical treatments. METHODS: PubMed was searched using the terms sleep-related painful erections, nocturnal priapism, treatment, and sleep-related erections...
December 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29186205/narcolepsy-susceptibility-gene-ccr3-modulates-sleep-wake-patterns-in-mice
#8
Hiromi Toyoda, Yoshiko Honda, Susumu Tanaka, Taku Miyagawa, Makoto Honda, Kazuki Honda, Katsushi Tokunaga, Tohru Kodama
Narcolepsy is caused by the loss of hypocretin (Hcrt) neurons and is associated with multiple genetic and environmental factors. Although abnormalities in immunity are suggested to be involved in the etiology of narcolepsy, no decisive mechanism has been established. We previously reported chemokine (C-C motif) receptor 3 (CCR3) as a novel susceptibility gene for narcolepsy. To understand the role of CCR3 in the development of narcolepsy, we investigated sleep-wake patterns of Ccr3 knockout (KO) mice. Ccr3 KO mice exhibited fragmented sleep patterns in the light phase, whereas the overall sleep structure in the dark phase did not differ between Ccr3 KO mice and wild-type (WT) littermates...
2017: PloS One
https://www.readbyqxmd.com/read/29183826/developmental-ethanol-induced-sleep-fragmentation-behavioral-hyperactivity-cognitive-impairment-and-parvalbumin-cell-loss-are-prevented-by-lithium-co-treatment
#9
M Lewin, M Ilina, J Betz, K Masiello, M Hui, D A Wilson, M Saito
Developmental ethanol exposure is a well-known cause of lifelong cognitive deficits, behavioral hyperactivity, emotional dysregulation, and more. In healthy adults, sleep is thought to have a critical involvement in each of these processes. Our previous work has demonstrated that some aspects of cognitive impairment in adult mice exposed at postnatal day 7 (P7) to ethanol (EtOH) correlate with slow-wave sleep (SWS) fragmentation (Wilson et al., 2016). We and others have also previously demonstrated that co-treatment with LiCl on the day of EtOH exposure prevents many of the anatomical and physiological impairments observed in adults...
November 26, 2017: Neuroscience
https://www.readbyqxmd.com/read/29159864/effects-of-music-during-daytime-rest-in-the-intensive-care-unit
#10
Isabella P Hansen, Leanne Langhorn, Pia Dreyer
BACKGROUND: Sleep is essential to the recovery of patients in the intensive care unit. Patients in the intensive care unit frequently experience poor sleep, characterized by sleep deprivation, sleep fragmentation and abnormal sleep architecture. Factors affecting sleep are multifactorial. AIM: To investigate the effects of music on self-reported quality of sleep during daytime rest among patients in the intensive care unit. STUDY DESIGN: A randomized controlled trial...
November 20, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/29157258/impact-of-earplugs-and-eye-mask-on-sleep-in-critically-ill-patients-a-prospective-randomized-study
#11
Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf, Thomas Similowski
BACKGROUND: Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was to evaluate the impact of earplugs and eye mask on sleep architecture in ICU patients. METHODS: A single-center randomized controlled trial of 64 ICU patients was conducted from July 2012 to December 2013. Patients were randomly assigned to sleep with or without earplugs and an eye mask from inclusion until ICU discharge...
November 21, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29154950/murine-models-of-sleep-apnea-functional-implications-of-altered-macrophage-polarity-and-epigenetic-modifications-in-adipose-and-vascular-tissues
#12
Wojciech Trzepizur, Rene Cortese, David Gozal
Obstructive sleep apnea (OSA) is a highly prevalent disease across the lifespan, is characterized by chronic intermittent hypoxia and sleep fragmentation, and has been independently associated with substantial cardiometabolic morbidity. However, the reversibility of end-organ morbidity with treatment is not always apparent, suggesting that both tissue remodeling and epigenetic mechanisms may be operationally involved. Here, we review the cumulative evidence focused around murine models of OSA to illustrate the temporal dependencies of cardiometabolic dysfunction and its reversibility, and more particularly to discuss the critical contributions of tissue macrophages to adipose tissue insulin resistance and vascular atherogenesis...
November 15, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29148047/plasma-copeptin-levels-in-patients-with-restless-legs-syndrome
#13
S Topaloglu Tuac, S Ozben, M Koseoglu Bitnel, A Koksal, E Kucuksayan, A Hanikoğlu, T Ozben
OBJECTIVES: Copeptin, the C-terminal fragment of antidiuretic hormone, is a new biomarker that has been found to be elevated in several disorders and could be related with prognosis. This study aimed to compare plasma copeptin levels in patients with restless legs syndrome (RLS) with healthy individuals and to investigate whether plasma copeptin levels were associated with the severity of disease. MATERIAL AND METHODS: 41 patients with primary RLS, who were followed in Bakirkoy Psychiatry and Neurology Research and Training Hospital and 41 age- and sex-matched healthy individuals were included into the study...
November 17, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29144185/rest-activity-circadian-rhythm-and-sleep-quality-in-patients-with-binge-eating-disorder
#14
E Roveda, A Montaruli, L Galasso, C Pesenti, E Bruno, P Pasanisi, M Cortellini, S Rampichini, S Erzegovesi, A Caumo, F Esposito
Recent findings suggest that altered rest-activity circadian rhythms (RARs) are associated with a compromised health status. RARs abnormalities have been observed also in several pathological conditions, such as cardiovascular, neurological, and cancer diseases. Binge eating disorder (BED) is the most common eating disorder, with a prevalence of 3.5% in women and 2% in men. BED and its associate obesity and motor inactivity could induce RARs disruption and have negative consequences on health-related quality of life...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29125327/obstructive-sleep-apnea-severity-affects-amyloid-burden-in-cognitively-normal-elderly-a-longitudinal-study
#15
Ram A Sharma, Andrew W Varga, Omonigho M Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S Babb, Kaj Blennow, Henrik Zetterberg, Shou E Lu, Sandra G Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gosselin, Girardin Jean-Louis, David M Rapoport, Mony J de Leon, Indu Ayappa, Ricardo S Osorio
RATIONALE: Recent evidence suggests that Obstructive Sleep Apnea (OSA) may be a risk factor for developing Mild Cognitive Impairment and Alzheimer's disease. However, how sleep apnea affects longitudinal risk for Alzheimer's disease is less well understood. OBJECTIVE: To test the hypothesis that there is an association between severity of OSA and longitudinal increase in amyloid burden in cognitively normal elderly. METHODS: Data was derived from a 2-year prospective longitudinal study that sampled community-dwelling healthy cognitively normal elderly...
November 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29123651/recent-advances-in-managing-and-understanding-enuresis
#16
REVIEW
Charlotte Van Herzeele, Johan Vande Walle, Karlien Dhondt, Kristian Vinter Juul
Enuresis, particularly in children during sleep, can be a debilitating condition, affecting the quality of life of the child and his or her family. The pathophysiology of nocturnal enuresis, though not clear, revolves around the inter-related mechanisms of overactive bladder, excessive nocturnal urine production, and sleep fragmentation. The first mechanism is more related to isolated nocturnal voiding, whereas the latter two are more related to nocturnal enuresis, in which circadian variations in arginine vasopressin hormone play a key role...
2017: F1000Research
https://www.readbyqxmd.com/read/29123082/supramammillary-glutamate-neurons-are-a-key-node-of-the-arousal-system
#17
Nigel P Pedersen, Loris Ferrari, Anne Venner, Joshua L Wang, Stephen B G Abbott, Nina Vujovic, Elda Arrigoni, Clifford B Saper, Patrick M Fuller
Basic and clinical observations suggest that the caudal hypothalamus comprises a key node of the ascending arousal system, but the cell types underlying this are not fully understood. Here we report that glutamate-releasing neurons of the supramammillary region (SuM(vglut2)) produce sustained behavioral and EEG arousal when chemogenetically activated. This effect is nearly abolished following selective genetic disruption of glutamate release from SuM(vglut2) neurons. Inhibition of SuM(vglut2) neurons decreases and fragments wake, also suppressing theta and gamma frequency EEG activity...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29103805/a-genetically-defined-circuit-for-arousal-from-sleep-during-hypercapnia
#18
Satvinder Kaur, Joshua L Wang, Loris Ferrari, Stephen Thankachan, Daniel Kroeger, Anne Venner, Michael Lazarus, Andrew Wellman, Elda Arrigoni, Patrick M Fuller, Clifford B Saper
The precise neural circuitry that mediates arousal during sleep apnea is not known. We previously found that glutamatergic neurons in the external lateral parabrachial nucleus (PBel) play a critical role in arousal to elevated CO2 or hypoxia. Because many of the PBel neurons that respond to CO2 express calcitonin gene-related peptide (CGRP), we hypothesized that CGRP may provide a molecular identifier of the CO2 arousal circuit. Here, we report that selective chemogenetic and optogenetic activation of PBelCGRP neurons caused wakefulness, whereas optogenetic inhibition of PBelCGRP neurons prevented arousal to CO2, but not to an acoustic tone or shaking...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29102236/rem-sleep-behavior-disorder-portends-poor-prognosis-in-parkinson-s-disease-a-systematic-review
#19
REVIEW
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. Aside from its significance as a predictor of PD, RBD in PD may imply more than merely screaming at night and experiencing sleep fragmentation. To probe its significance as a prognostic factor in PD, we performed a systematic literature review. Analysis of prospective studies reveals baseline RBD confers a higher risk of developing dementia and hallucinations. In cross-sectional studies, RBD is associated with the non-tremor predominant motor phenotype and autonomic dysfunction...
October 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29082554/sleep-fragmentation-and-parkinson-s-disease-pathology-in-older-adults-without-parkinson-s-disease
#20
Shahmir Sohail, Lei Yu, Julie A Schneider, David A Bennett, Aron S Buchman, Andrew S P Lim
INTRODUCTION: Patients with Parkinson's disease (PD) frequently experience disrupted sleep, and several sleep abnormalities are associated with an increased risk of incident PD. However, there are few data concerning the relationship between objectively quantified sleep disruption and the cardinal histopathological features of PD, especially in individuals without clinical PD. METHODS: We studied 269 older adults without PD who had participated in the Rush Memory and Aging Project and undergone uniform structured neuropathologic evaluations upon death...
December 2017: Movement Disorders: Official Journal of the Movement Disorder Society
keyword
keyword
109221
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"