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https://www.readbyqxmd.com/read/28742193/relationship-between-il-1%C3%AE-polymorphisms-and-obstructive-sleep-apnea-syndrome
#1
T-Y Tang, X-X Zhou, H Huang, Q-D Huang
OBJECTIVE: To explore the relationship between obstructive sleep apnea syndrome (OSAS) and polymorphism in the IL-1β gene. PATIENTS AND METHODS: We recruited 164 OSAS patients to the observation group and 146 healthy people to the control group during the same period. Using RFLP (Restriction Fragment Length Polymorphism), we detected higher G/G and C/C rates on locus 154 of the IL-1β gene in the OSAS patients compared with the control group. RESULTS: Quantitative fluorescence PCR results showed no significant differences in the mRNA expression between the OSAS patients and the healthy people...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28739207/obstructive-sleep-apnea-and-hallmarks-of-aging
#2
REVIEW
Laetitia S Gaspar, Ana Rita Álvaro, Joaquim Moita, Cláudia Cavadas
Obstructive sleep apnea (OSA) is one of the most common sleep disorders. Since aging is a risk factor for OSA development, it is expected that its prevalence will increase with the current increase in life span. In recent years, several studies have shown that OSA potentially contributes to functional decline, mainly prompted by chronic intermittent hypoxia and sleep fragmentation. Here, we propose that OSA might anticipate/aggravate aging by inducing cellular and molecular impairments that characterize the aging process, such as stem cell exhaustion, telomere attrition and epigenetic changes...
July 21, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28738382/advanced-concepts-in-the-pathophysiology-of-obstructive-sleep-apnea
#3
David P White
The primary pathological event in the disorder obstructive sleep apnea (OSA) is the partial or complete closure of the pharyngeal airway during sleep in an individual with a widely patent airway during wakefulness. This yields an apnea or hypopnea with resulting hypoxia and hypercapnia, and most often requires an arousal to terminate the event. These events occur in a repetitive manner during sleep, yielding intermittent hypoxia and sleep fragmentation with their associated adverse effects on the health and quality of life of the afflicted individual...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738327/updated-concepts-on-treatment-outcomes-for-obstructive-sleep-apnea
#4
Victor Certal, Robson Capasso
Obstructive sleep apnea is a highly prevalent and poorly understood condition that not only leads to significant individual patient health damage, but carries a large societal cost secondary to excessive healthcare utilization, motor-vehicle accidents, and work absenteeism. While a significant fund of knowledge about its damaging effects on the cardiovascular system and neural pathways has been gathered over the past few decades, the translation to direct patient care still presents numerous challenges. With the exception of clear issues such as socially unacceptable snoring and breathing irregularities, the exact cause and effect relationship between airway narrowing, hypoxemia, and sleep fragmentation with subjective sleep-related complaints and neurocognitive symptoms is less clear...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28726359/earplugs-during-the-first-night-after-cardiothoracic-surgery-may-improve-a-fast-track-protocol
#5
Johannes Menger, Bernhard Urbanek, Keso Skhirtladze-Dworschak, Viktoria Wolf, Arabella Fischer, Harald Rinösl, Martin Dworschak
BACKGROUND: Sleep deprivation after major surgery is common and associated with worse outcome. Noise is one important reason for sleep fragmentation, which contributes to enhanced morbidity. The purpose of this work was to evaluate the impact of earplugs on patients' sleep quality during their first night after cardiothoracic surgery to eventually improve an existing fast-track concept. METHODS: Sixty-three patients undergoing cardiothoracic surgery eligible for a postoperative fast- track regimen on our cardiothoracic post anaesthesia care unit (C-PACU) were prospectively included...
July 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28715063/peripehral-artery-atherosclerotic-disease-and-sleep-disordered-breathing-paradise-trial-protocol-for-an-observational-cohort-study
#6
Filip M Szymański, Zbigniew Gałązka, Anna E Płatek, Dariusz Górko, Tomasz Ostrowski, Karolina Adamkiewicz, Paweł Łęgosz, Anna Ryś, Karolina Semczuk, Krzysztof Celejewski, Krzysztof J Filipiak
BACKGROUND: Peripheral arterial disease (PAD) is in fact a group of disease entities with different symptoms and course but a common underlying cause that is atherosclerosis. Atherosclerosis is known to be aggravated by several cardiovascular risk factors, including obstructive sleep apnea (OSA). AIM: Following paper is a protocol for Peripehral ARtery Atherosclerotic DIsease and SlEep disordered breathing (PARADISE) trial, which aims to describe the prevalence of OSA in PAD patients scheduled for revascularization and to determine the effect of OSA on the procedure outcomes...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28695622/sleep-disturbance-by-pramipexole-is-modified-by-meis1-in-mice
#7
Aaro V Salminen, Barbara Schormair, Cornelia Flachskamm, Miguel Torres, Bertram Müller-Myhsok, Mayumi Kimura, Juliane Winkelmann
Meis homeobox 1 (Meis1) is a transcription factor functioning in the development of the nervous system and the cardiovascular system. Both common and rare variants within the gene have been associated with restless legs syndrome (RLS), while its association with symptoms of insomnia has also been discovered recently. RLS is associated with sleep disturbances, and while Meis1 haploinsufficiency is one of the most promising strategies for an RLS animal model, sleep phenotyping of Meis1 knockout mice has never been conducted...
July 11, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28692233/-sleep-apnea-in-pregnancy
#8
Wawrzyniec Rieder, Raphaël Heinzer, David Baud
Snoring, chronic rhinitis and fragmentation of sleep are common symptoms in pregnancy, especially in the third trimester. The prevalence of obstructive sleep apnea is also increased in pregnant women and can be associated with pregnancy induced hypertension, preeclampsia and diabetes mellitus. The fetus is as well exposed to a higher risk of prematurity and intra-uterine growth restriction. Given the lack of adequate screening tool, the diagnosis of obstructive sleep apnea is a challenge for the physician and a high degree of clinical suspicion is necessary in order to identify the patients at risk and propose an appropriate management...
October 26, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28681187/intermittent-hypoxia-and-unsaturated-aldehydes-effects-on-oral-epithelial-wound-healing
#9
Katia Avezov, Lena Lavie, Dror Aizenbud
Obstructive sleep apnea (OSA) is a highly prevalent sleep breathing disorder characterized by intermittent hypoxia (IH), leading to blood hypoxemia, hypercapnia, and sleep fragmentation. Studies on the effects of OSA on oral epithelial tissue healing are limited. Smoking is considered a risk factor for OSA through the exposure to chemically active toxins, present in the smoke. Acrolein is the most chemically active unsaturated aldehyde, impairing a variety of biological processes. The aim of this study was to determine the effect of IH on oral epithelial tissue healing, with and without acrolein...
July 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28676332/circulating-exosomes-in-obstructive-sleep-apnea-as-phenotypic-biomarkers-and-mechanistic-messengers-of-end-organ-morbidity
#10
REVIEW
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, David Gozal
Obstructive sleep apnea (OSA), the most severe form of sleep disordered breathing, is characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic hypercapnia. OSA is associated with increased risk for morbidity and mortality affecting cardiovascular, metabolic, and neurocognitive systems, and more recently with non-alcoholic fatty liver disease (NAFLD) and cancer-related deaths. Substantial variability in OSA outcomes suggests that genetically-determined and environmental and lifestyle factors affect the phenotypic susceptibility to OSA...
July 1, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28675258/narcolepsy-cataplexy-and-psychosis-a-case-study
#11
F Canellas-Dols, C Delgado, C Arango-Lopez, R Peraita-Adrados
AIMS: To report a challenging patient a girl who developed narcolepsyy with cataplexy (NT1) and a psychosis during adolescence. To discuss diagnostic and therapeutic challenges of the comorbid cases. CASE REPORT: A 14-year-old girl was referred to Sleep and Epilepsy Unit for excessive daytime sleepiness, impaired nocturnal sleep, binge eating and weight gain, over the last year. After being diagnosed with a NT1 the patient was treated with modafinil and sodium oxybate...
July 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28673760/the-influence-of-sleep-disordered-breathing-in-rem-sleep-behavior-disorder
#12
Paulo Bugalho, Marcelo Mendonça, Raquel Barbosa, Manuel Salavisa
OBJECTIVES/BACKGROUND: Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1. the intensity of non-motor symptoms between RBD patients with (RBD-OSA) and without OSA (RBD-non-OSA), and 2. polysomnographic features between RBD-OSA and OSA without RBD (OSA-non-RBD) patients...
June 1, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28672086/circulating-branched-chain-amino-acids-in-children-with-obstructive-sleep-apnea
#13
Antonia Barceló, Josep Miquel Bauça, José Antonio Peña-Zarza, Daniel Morell-Garcia, Aina Yáñez, Gerardo Pérez, Javier Piérola, Nuria Toledo, Mónica de la Peña
INTRODUCTION: The effects of obstructive sleep apnea (OSA) on the metabolic system are not well understood, especially in children. Recent studies have provided evidence of the modulation of insulin action by branched-chain amino acids (BCAAs) and suggested novel mechanistic relationships between glucose and amino acid metabolic pathways. We hypothesized that plasma BCAA levels may serve as biomarkers of insulin resistance and metabolic dysfunction in children with OSA. METHODS: A polysomnography was conducted for the diagnosis of OSA in 90 snoring children, in a tertiary hospital...
August 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28671141/poor-sleep-quality-and-progression-of-gait-impairment-in-an-incident-parkinson-s-disease-cohort
#14
Seán O'Dowd, Brook Galna, Rosie Morris, Rachael A Lawson, Claire McDonald, Alison J Yarnall, David J Burn, Lynn Rochester, Kirstie N Anderson
Abnormal sleep may associate with cognitive decline in Parkinson's disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28666745/the-clinical-spectrum-of-childhood-narcolepsy
#15
REVIEW
Emanuela Postiglione, Elena Antelmi, Fabio Pizza, Michel Lecendreux, Yves Dauvilliers, Giuseppe Plazzi
Narcolepsy type 1 is a life-long, severe, multifaceted disease often arising in childhood or adolescence. Beyond the classical symptoms (excessive daytime sleepiness, cataplexy, hallucinations, sleep paralysis and nocturnal fragmented sleep), metabolic, endocrinological, psychiatric and psychosocial aspects must be considered. Despite the increased awareness after H1N1 pandemic influenza and vaccination, narcolepsy is still misdiagnosed and unrecognized. The peculiar presentation of symptoms in narcoleptic children could in part explain the misdiagnoses...
May 8, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28661921/fragmented-sleep-enhances-postoperative-neuroinflammation-but-not-cognitive-dysfunction-really
#16
Song Huang, Gen Wei, Fuzhou Hua
No abstract text is available yet for this article.
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28657410/the-relationship-between-fragmented-qrs-and-non-dipper-status-in-hypertensive-patients-without-left-ventricular-hypertrophy
#17
Zulkif Tanriverdi, Mehmet Eyuboglu, Tugba Bingol Tanriverdi, Abdullah Nurdag, Recep Demirbag
BACKGROUND: Fragmented QRS (fQRS) has been shown to be associated with poor outcome in various cardiovascular diseases. Non-dipper hypertension is also associated with increased cardiovascular mortality. The aim of our study is to investigate the relationship between fQRS and non-dipper status in hypertensive patients without left ventricular hypertrophy (LVH). METHODS: This study included 106 hypertensive patients without LVH. Patients were divided into two groups: dipper hypertension and non-dipper hypertension...
June 28, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28652746/association-between-serotonin-transporter-polymorphisms-5-httlpr-and-the-madrs-dysphoria-retardation-and-vegetative-subscale-scores-in-the-treatment-of-depression
#18
Hitoshi Takahashi, Hisashi Higuchi, Kazuhiro Sato, Mitsuhiro Kamata, Keizo Yoshida, Katsuji Nishimura
OBJECTIVE: We investigated the association between serotonin- or 5-hydroxytryptamine (5-HT)-related gene polymorphisms and response to antidepressant treatment in a specific symptom cluster of major depression by using the three-factor model of the Montgomery-Åsberg Depression Rating Scale (MADRS), ie, dysphoria (items of sadness, pessimistic thoughts, and suicidal thoughts), retardation (items of lassitude, inability to feel, apparent sadness, and concentration difficulties), and vegetative symptoms (items of reduced sleep, reduced appetite, and inner tension)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28651353/protein-tyrosine-phosphatase-1b-mediates-sleep-fragmentation-induced-insulin-resistance-and-visceral-adipose-tissue-inflammation-in-mice
#19
David Gozal, Abdelnaby Khalyfa, Zhuanghong Qiao, Mahzad Akbarpour, Rosanna Maccari, Rosaria Ottanà
Study Objectives: Sleep fragmentation (SF) is highly prevalent and has emerged as an important contributing factor to obesity and metabolic syndrome. We hypothesized that SF-induced increases in protein tyrosine phosphatase-1B (PTP-1B) expression and activity underlie increased food intake, inflammation, and leptin and insulin resistance. Methods: Wild type (WT) and ObR-PTP-1b-/- mice (Tg) were exposed to SF and control sleep (SC), and food intake was monitored...
June 23, 2017: Sleep
https://www.readbyqxmd.com/read/28643350/habitual-sleep-and-kidney-function-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort-study
#20
Kristen L Knutson, James Lash, Ana C Ricardo, James Herdegen, J D Thornton, Mahboob Rahman, Nicolas Turek, Janet Cohan, Lawrence J Appel, Lydia A Bazzano, Manjula K Tamura, Susan P Steigerwalt, Matthew R Weir, Eve Van Cauter
Physiological evidence suggests that sleep modulates kidney function. Our objective was to examine the cross-sectional association between kidney function and objectively-estimated habitual sleep duration, quality and timing in a cohort of patients with mild to moderate chronic kidney disease. This study involved two US clinical centers of the Chronic Renal Insufficiency Cohort (CRIC) study, including 432 participants in a CRIC ancillary sleep study. Habitual sleep duration, quality and timing were measured using wrist actigraphy for 5-7 days...
June 23, 2017: Journal of Sleep Research
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