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auditory brainstem implants

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https://www.readbyqxmd.com/read/27898605/initial-results-of-a-safety-and-feasibility-study-of-auditory-brainstem-implantation-in-congenitally-deaf-children
#1
Eric P Wilkinson, Laurie S Eisenberg, Mark D Krieger, Marc S Schwartz, Margaret Winter, Jamie L Glater, Amy S Martinez, Laurel M Fisher, Robert V Shannon
OBJECTIVE: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency. STUDY DESIGN: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period. SETTING: Tertiary children's hospital and university-based pediatric speech/language/hearing center. INTERVENTION(S): ABI implantation and postsurgical programming...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27862478/reductions-in-cortical-alpha-activity-enhancements-in-neural-responses-and-impaired-gap-detection-caused-by-sodium-salicylate-in-awake-guinea-pigs
#2
Joel I Berger, Ben Coomber, Mark N Wallace, Alan R Palmer
Tinnitus chronically affects between 10-15% of the population but despite its prevalence, the underlying mechanisms are still not properly understood. One experimental model involves administration of high doses of sodium salicylate, as this is known to reliably induce tinnitus in both humans and animals. Guinea pigs were implanted with chronic electrocorticography (ECoG) electrode arrays, with silver ball electrodes placed on the dura over left and right auditory cortex. Two more electrodes were positioned over the cerebellum to monitor auditory brainstem responses (ABRs)...
November 12, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27831887/modeling-intracochlear-magnetic-stimulation-a-finite-element-analysis
#3
Sagarika Mukesh, D T Blake, B J McKinnon, P T Bhatti
This study models induced electric fields, and their gradient, produced by pulsatile current stimulation of submillimeter inductors for cochlear implantation. Using finite-element analysis, the lower chamber of the cochlea, scala tympani, is modeled as a cylindrical structure filled with perilymph bounded by tissue, bone, and cochlear neural elements. Single inductors as well as an array of inductors are modeled. The coil strength (~100 nH) and excitation parameters (Peak current of 1 - 5 A, Voltages of 16 - 20 V) are based on a formative feasibility study conducted by our group...
November 2, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27816614/developmental-exposure-to-an-environmental-pcb-mixture-delays-the-propagation-of-electrical-kindling-from-the-amygdala
#4
Suren B Bandara, Renee N Sadowski, Susan L Schantz, Mary E Gilbert
Developmental PCB exposure impairs hearing and induces brainstem audiogenic seizures in adult offspring. The degree to which this enhanced susceptibility to seizure is manifest in other brain regions has not been examined. Thus, electrical kindling of the amygdala was used to evaluate the effect of developmental exposure to an environmentally relevant PCB mixture on seizure susceptibility in the rat. Female Long-Evans rats were dosed orally with 0 or 6mg/kg/day of the PCB mixture dissolved in corn oil vehicle 4 weeks prior to mating and continued through gestation and up until postnatal day (PND) 21...
November 2, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27755361/tinnitus-suppression-after-auditory-brainstem-implantation-in-patients-with-neurofibromatosis-type-2
#5
Daniel S Roberts, Steve Otto, Brian Chen, Kevin A Peng, Marc S Schwartz, Derald E Brackmann, John W House
OBJECTIVE: To evaluate whether an auditory brainstem implant (ABI) can impact levels of tinnitus in neurofibromatosis type-2 (NF2) patients who have undergone translabyrinthine craniotomy for vestibular schwannoma (VS) removal and to evaluate the burden of tinnitus in these patients. STUDY DESIGN: A retrospective case series and patient survey. SETTING: Tertiary neurotologic referral center. PATIENTS: NF2 patients who underwent translabyrinthine removal of VS and ABI placement between 1994 and 2015...
October 12, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27733103/acceleration-of-healing-of-traumatic-tympanic-membrane-perforation-in-rats-by-implanted-collagen-membrane-integrated-with-collagen-binding-basic-fibroblast-growth-factor
#6
Qin Shi, Dan Zhang, Zhen Huang, Peng Sun, Haiping Huang, Yunmei Zhang, Jianwu Dai, Jisheng Liu
Traumatic tympanic membrane (TM) perforation is very common in clinical practice. Several biomaterials have been reported to play a role in TM reparation, whereas their functional recovery is limited when used alone. Meanwhile, the administration of bio-factors could promote functional recovery, but rapid distribution and short half-time obstruct their application. In order to study the effect on of traumatic TM regeneration, we prepared collagen membrane (CM) integrated with collagen-binding basic fibroblast growth factor (CBD-bFGF) and implanted into the injury site of perforated TM in Sprague-Dawley (SD) rats...
October 12, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27716925/auditory-brainstem-implant-program-development
#7
Marc S Schwartz, Eric P Wilkinson
OBJECTIVE: Auditory brainstem implants (ABIs), which have previously been used to restore auditory perception to deaf patients with neurofibromatosis type 2 (NF2), are now being utilized in other situations, including treatment of congenitally deaf children with cochlear malformations or cochlear nerve deficiencies. Concurrent with this expansion of indications, the number of centers placing and expressing interest in placing ABIs has proliferated. Because ABI placement involves posterior fossa craniotomy in order to access the site of implantation on the cochlear nucleus complex of the brainstem and is not without significant risk, we aim to highlight issues important in developing and maintaining successful ABI programs that would be in the best interests of patients...
September 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27714498/effect-of-a-liposomal-hyaluronic-acid-gel-loaded-with-dexamethasone-in-a-guinea-pig-model-after-manual-or-motorized-cochlear-implantation
#8
Elisabeth Mamelle, Naila El Kechai, Benjamin Granger, Olivier Sterkers, Amélie Bochot, Florence Agnely, Evelyne Ferrary, Yann Nguyen
Goals of cochlear implantation have shifted from complete insertion of the cochlear electrode array towards low traumatic insertion with minimally invasive techniques. The aim of this study was first to evaluate, in a guinea pig model of cochlear implantation, the effect of a motorized insertion technique on hearing preservation. The second goal was to study a new gel formulation containing dexamethasone phosphate loaded in liposomes (DEX-P). Guinea pigs had a unilateral cochlear implantation with either a manual technique (n = 12), or a motorized technique (n = 15), with a 0...
October 6, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27704245/pediatric-neurofibromatosis-type-2-clinical-and-molecular-presentation-management-of-vestibular-schwannomas-and-hearing-rehabilitation
#9
Nicolas -Xavier Bonne, Rabih Aboukais, Marc Baroncini, Audrey Hochart, Pierre Leblond, Franck Broly, Frédérique Dubrulle, Jean-Paul Lejeune, Christophe Vincent
OBJECTIVE: This study aims to describe the clinical and molecular presentation of pediatric neurofibromatosis type 2 (NF2) and the subsequent management of vestibular schwannomas (VS) and hearing rehabilitation. METHODS: This is a single-center retrospective study of neurofibromatosis type 2 diagnosed before the age of 18 years old from 1997. Natural history of vestibular schwannomas and surgical outcomes were evaluated using volumetric MRI, hearing, and facial nerve assessment...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27689303/difference-of-auditory-brainstem-responses-by-stimulating-to-round-and-oval-window-in-animal-experiments
#10
Jyung Hyun Lee, Hyo Soon Park, Qun Wei, Myoung Nam Kim, Jin-Ho Cho
ABSTACT To ensure the safety and efficacy of implantable hearing aids, animal experiments are an essential developmental procedure, in particular, auditory brainstem responses (ABRs) can be used to verify the objective effectiveness of implantable hearing aids. This study measured and compared the ABRs generated when applying the same vibration stimuli to an oval window and round window. The ABRs were measured using a TDT system 3 (TDT, USA), while the vibration stimuli were applied to a round window and oval window in 4 guinea pigs using a piezo-electric transducer with a proper contact tip...
September 30, 2016: Bioengineered
https://www.readbyqxmd.com/read/27668836/reorganization-of-neural-systems-mediating-peripheral-visual-selective-attention-in-the-deaf-an-optical-imaging-study
#11
Jenessa L Seymour, Kathy A Low, Edward L Maclin, Antonio M Chiarelli, Kyle E Mathewson, Monica Fabiani, Gabriele Gratton, Matthew W G Dye
Theories of brain plasticity propose that, in the absence of input from the preferred sensory modality, some specialized brain areas may be recruited when processing information from other modalities, which may result in improved performance. The Useful Field of View task has previously been used to demonstrate that early deafness positively impacts peripheral visual attention. The current study sought to determine the neural changes associated with those deafness-related enhancements in visual performance...
September 23, 2016: Hearing Research
https://www.readbyqxmd.com/read/27651152/temporal-processing-capacity-in-auditory-deprived-superior-paraolivary-neurons-is-rescued-by-sequential-plasticity-during-early-development
#12
Sara C M Leijon, Stefan Peyda, Anna K Magnusson
The leading treatments for severe hearing disabilities work on the principle of conveying electrical pulses to the auditory brainstem that enable perception of speech. It is currently not known how well the brainstem neurons specialized for decoding such coarse sound information develop when deprived of auditory input activity. Here, we used congenitally deaf α1D(-/-) mice, lacking activity in the auditory nerve, to investigate the superior paraolivary nucleus (SPON) - a prominent mammalian brainstem structure that responds selectively to sound pulses by rebound spiking...
September 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27603148/patient-reported-measures-of-hearing-loss-and-tinnitus-in-pediatric-cancer-and-hematopoietic-stem-cell-transplantation-a-systematic-review
#13
Daniel Stark, Abby R Rosenberg, Donna Johnston, Kristin Knight, Lizzie Caperon, Elizabeth Uleryk, A Lindsay Frazier, Lillian Sung
Purpose: We identified studies that described use of any patient-reported outcome scale for hearing loss or tinnitus among children and adolescents and young adults (AYAs) with cancer or hematopoietic stem cell transplantation (HSCT) recipients. Method: In this systematic review, we performed electronic searches of OvidSP MEDLINE, EMBASE, and PsycINFO to August 2015. We included studies if they used any patient-reported scale of hearing loss or tinnitus among children and AYAs with cancer or HSCT recipients...
October 1, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27579988/electrically-evoked-auditory-event-related-responses-in-patients-with-auditory-brainstem-implants-morphological-characteristics-test-retest-reliability-effects-of-stimulation-level-and-association-with-auditory-detection
#14
Shuman He, Tyler C McFayden, Holly F B Teagle, Matthew Ewend, Lillian Henderson, Craig A Buchman
OBJECTIVE: This study aimed to (1) characterize morphological characteristics of the electrically evoked cortical auditory event-related potentials (eERPs) and explore the potential association between onset eERP morphology and auditory versus nonauditory stimulation; (2) assess test-retest reliability of onset eERPs; (3) investigate effects of stimulation level on onset eERPs; and (4) explore the feasibility of using the onset eERP to estimate the lowest stimulation level that can be detected for individual stimulating electrodes in patients with auditory brainstem implants (ABIs)...
November 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27573863/models-of-the-electrically-stimulated-binaural-system-a-review
#15
Mathias Dietz
In an increasing number of countries, the standard treatment for deaf individuals is moving toward the implantation of two cochlear implants. Today's device technology and fitting procedure, however, appears as if the two implants would serve two independent ears and brains. Many experimental studies have demonstrated that after careful matching and balancing of left and right stimulation in controlled laboratory studies most patients have almost normal sensitivity to interaural level differences and some sensitivity to interaural time differences (ITDs)...
2016: Network: Computation in Neural Systems
https://www.readbyqxmd.com/read/27556522/effects-of-implantation-and-reimplantation-of-cochlear-implant-electrodes-in-an-in-vivo-animal-experimental-model-macaca-fascicularis
#16
Jorge de Abajo, Raquel Manrique-Huarte, Ignacio Sanhueza, Laura Alvarez-Gómez, Cristina Zulueta-Santos, Diego Calavia, Fernando Ramírez, Manuel Manrique
OBJECTIVES: The objectives of this study were to evaluate the effect of reimplanting a cochlear implant electrode in animal normal-hearing cochlea to propose measures that may prevent cochlear injury and, given its close phylogenetic proximity to humans, to evaluate the macaque as a model for electroacoustic stimulation. DESIGN: Simultaneous, bilateral surgical procedures in a group of 5 normal-hearing specimens (Macaca fascicularis) took place in a total of 10 ears...
August 22, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27525707/auditory-brainstem-implantation-in-neurofibromatosis-type-2-experience-from-the-manchester-programme
#17
Richard Thomas Ramsden, Simon Richard Mackenzie Freeman, Simon Kingsley Wickham Lloyd, Andrew Thomas King, Xin Shi, Charlotte Lucy Ward, Susan Mary Huson, Deborah Jane Mawman, Martin Paul O'Driscoll, Dafydd Gareth Evans, Scott Alexander Rutherford
OBJECTIVE: To describe the experience of auditory brainstem implantation (ABI) in patients with Neurofibromatosis type 2 (NF2). STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral centre. PATIENTS: Implanted with a Cochlear ABI22 or ABI24M between 1994 and 2009 because of NF2 disease. INTERVENTION(S): Rehabilitative. MAIN OUTCOME MEASURE(S): Surgical complication rate; audiological outcomes...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27525617/the-effect-of-round-window-sealants-on-delayed-hearing-loss-in-a-guinea-pig-model-of-cochlear-implantation
#18
David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Stephen O'Leary
AIM: To determine whether the type of material used to seal the cochlea after round window cochlear implantation influences delayed hearing loss. BACKGROUND: Cochlear implants are now prescribed to patients with residual, low-frequency hearing. This hearing-which provides perceptual benefits for the implanted ear-is frequently lost for unknown reasons weeks to months after surgery in a proportion of patients. A post-surgical change in cochlear mechanics, related to the material used to seal the cochlea after round window implantation, may contribute to this loss...
September 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27519925/multichannel-cochlear-implant-for-selective-neuronal-activation-and-chronic-use-in-the-free-moving-mongolian-gerbil
#19
Armin Wiegner, Charles G Wright, Maike Vollmer
BACKGROUND: Animal models for chronic multichannel cochlear implant stimulation and selective neuronal activation contribute to a better understanding of auditory signal processing and central neural plasticity. NEW METHOD: This paper describes the design and surgical implantation of a multichannel cochlear implant (CI) system for chronic use in the free-moving gerbil. For chronic stimulation, adult-deafened gerbils were connected to a multichannel commutator that allowed low resistance cable rotation and stable electric connectivity to the current source...
August 9, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27510227/-preoperative-auditory-evaluation-and-postoperative-follow-up-in-cochlear-implantees-the-role-of-objective-measures
#20
W Shehata-Dieler, W Großmann
The primary diagnostic aim prior to cochlear implantation is establishment of a comprehensive and multidisciplinary diagnosis, in order to subsequently begin therapy as early as possible. Audiological evaluation prior to implantation employs a test battery-approach, including subjective and objective procedures. Objective measures show high reliability and therefore play a major role in the diagnosis of difficult-to-test subjects such as infants and young children. During postoperative follow-up, objective measures offer a valid method for analyzing the effects of different stimuli on the auditory system...
August 10, 2016: HNO
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