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auditory brainstem implants

John Ka Keung Sung, Betty Pui Ki Luk, Terence Ka Cheong Wong, Jiun Fong Thong, Hoi Tung Wong, Michael Chi Fai Tong
OBJECTIVE: This is a retrospective review of the impact of an Auditory Brainstem Implant (ABI) on the audiological rehabilitation and tonal language development of pediatric patients with prelingual profound deafness in Hong Kong. RESULTS: From January 2009 to February 2015, 11 pediatric patients with profound prelingual deafness received an ABI in Hong Kong (age range 1.67-3.75 years). Etiologies included Cochlear Nerve Deficiency in 7, Severe Cochlear Malformations in 2, and Retrocochlear Deafness in 2...
September 18, 2018: Audiology & Neuro-otology
Yadollah Zahed Pasha, Mohammad Zamani, Ali Hashemi Fard, Ermia Zahed Pasha
BACKGROUND: The purpose of this study was to investigate the results of hearing screening in all newborn infants, and their follow-up in Babol, northern Iran. METHODS: Between 2006 and 2014, all healthy neonates delivered in 3 hospitals were included in this cross-sectional study. Newborns were screened using the transient evoked otoacoustic emissions test before discharge. Those who failed to pass the examination were tested for auditory brainstem response (ABR) by the age of one month...
September 1, 2018: Archives of Iranian Medicine
Hanne Deprez, Robin Gransier, Michael Hofmann, Jan Wouters, Nicolas Verhaert
Acoustic hearing implants, such as direct acoustic cochlear implants (DACIs), can be used to treat profound mixed hearing loss. Electrophysiological responses in DACI subjects are of interest to confirm auditory processing intra-operatively, and to assist DACI fitting postoperatively. We present two related studies, focusing on DACI artifacts and electrophysiological measurements in DACI subjects, respectively. In the first study we aimed to characterize DACI artifacts, to study the feasibility of measuring frequency-specific electrophysiological responses in DACI subjects...
August 28, 2018: Hearing Research
Leena Asfour, David R Friedmann, William H Shapiro, J Thomas Roland, Susan B Waltzman
OBJECTIVE: To assess auditory brainstem implant (ABI) outcomes in children with a prospective study. METHODS: Twelve patients with cochlear nerve deficiency received an auditory brainstem implant. Patients were evaluated with age appropriate speech perception and production assessments, and health related quality of life (HRQoL) surveys for parents of subjects and for subjects if age appropriate. RESULTS: Twelve patients received an ABI without major complications...
October 2018: International Journal of Pediatric Otorhinolaryngology
Daniele Marchioni, Sheila Veronese, Marco Carner, Andrea Sacchetto, Luca Sacchetto, Barbara Masotto, Luca Bianconi
OBJECTIVE: Hearing restoration has always been a dream in vestibular schwannoma (VS) surgery. The aim of this study is to describe an endoscopic assisted transcanal retrocochlear approach to the internal auditory canal (IAC) with total removal of the VS; simultaneously we assessed the anatomical and functional aspects of hearing restoration with cochlear implant (CI). STUDY DESIGN: A retrospective case series. SETTING: Tertiary referral center...
August 30, 2018: Otology & Neurotology
Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol, Robert Cowan
OBJECTIVE: To compare the benefits of a dexamethasone-eluting array for hearing preservation and cochlear histopathology in low trauma (soft-surgery) and high trauma models of cochlear implant surgery. METHODS: Adult guinea pigs were implanted with an intra-cochlear array using two different surgical procedures: either a soft-surgery approach or following generation of electrode insertion trauma (high trauma). Two methods of dexamethasone delivery were evaluated: elution from an electrode array alone, and elution from a cochlear implant electrode array in combination with a pre-operative systemic injection...
August 20, 2018: Cochlear Implants International
T I Chugunova, V V Zherenkova, M V Goyhburg, L A Potalova, V V Mosin, V V Bakhshinyan, G A Tavartkiladze
The objective methods for the hearing examination of the patients after cochlear implantation provide an important tool for the speech processor fitting. The aim of the present study was to evaluate the possibilities and the informative value of the electrically evoked compound action potential (ECAP) and electrically evoked auditory brainstem response (EABR) combined recording technique. For this reason, the comparison of the ECAP and EABR thresholds with comfortable levels of stimulation, obtained on the basis of subjective response and psychophysical testing of the patients with good results after cochlear implantation was performed...
2018: Vestnik Otorinolaringologii
M R Lalayants, N B Brazhkina, E N Geptner, A V Kruglov, V V Barrlyak, G A Tavartkiladze
The objective of the present study was to estimate peculiarities of the auditory brainstem evoked potentials (ABR), auditory steady-state responses (ASSR) and cortical auditory evoked potentials (CAEP) in the children presenting with bilateral auditory neuropathy spectrum disorder (ANSD). The study included 100 patients with bilateral ANSD diagnosed based on the positive response of otoacoustic emissions (OAEs) and/or cochlear microphonic (CM) detection, while no synchronous neural activity was detected in the ABR test...
2018: Vestnik Otorinolaringologii
Serpil Ece Aras Öztürk, Selma Aktaş, Leman Tuba Karakurt, Ömer Necati Develioğlu, Zehra Murat, Fatma Çetinkaya, Seda Geylani Güleç
Aim: This study aimed to present the results of newborns who were referred to advanced audiology centers after newborn hearing screening, and to determine concordance of our results with the American Academy of Pediatrics guidelines about the ages of hearing loss, aid fitting, and cochlear implantation. Materials and Methods: A total of 7502 newborns were screened in Gaziosmanpaşa Taksim Research and Training Hospital between March 2014 and June 2016 using the transient otoacustic emissions test as the first two steps and automated auditory brainstem response test for the third step...
March 2018: Türk Pediatri Arşivi
Zhao Han, Chengjin Wang, Yuyan Gu, Ning Cong, Rui Ma, Fanglu Chi
BACKGROUND Kanamycin and subsequent furosemide administration was applied to the healthy guinea pigs to induce deafness. MATERIAL AND METHODS Of the deafened guinea pigs, 10 were further infused with anti-infection procedures (Group B) and the other 10 animals did not undergo anti-infection procedures (Group C). In Group B, the deafened animals were able to restore cochlear and middle ear functions following the anti-infection procedure. In Group C, all animals developed cochlear and middle ear infections. RESULTS Compared to the healthy guinea pigs, hair cells and spiral ganglion neurons (SGN) of deafened animals (in Group B and Group C) were severely damaged...
August 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Maria J Duarte, Vivek V Kanumuri, Lukas D Landegger, Osama Tarabichi, Sumi Sinha, Xiankai Meng, Ariel Edward Hight, Elliott D Kozin, Konstantina M Stankovic, M Christian Brown, Daniel J Lee
Optogenetics is a transformative technology based on light-sensitive microbial proteins, known as opsins, that enable precise modulation of neuronal activity with pulsed radiant energy. Optogenetics has been proposed as a means to improve auditory implant outcomes by reducing channel interaction and increasing electrode density, but the introduction of opsins into cochlear spiral ganglion neurons (SGNs) in vivo has been challenging. Here we test opsin delivery using a synthetically developed ancestral adeno-associated virus (AAV) vector called Anc80L65...
August 1, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Alireza Hedjrat, Konrad Schwager, Erich Hofmann, Robert Behr
Objective  Vestibular schwannomas (VSNs) account for the vast majority of lesions located in the cerebellopontine angle (CPA). The goals of VSN surgery are possible total tumor removal, intact facial nerve function, and preservation of cochlear nerve function. In cases of pre- or postoperative deafness, restoration of hearing with auditory brainstem implant (ABI) or cochlear implant (CI) is a promising treatment option with normally better results in CI than in ABI. The aim of this retrospective study is to evaluate cochlear ossification or obliteration secondary to a retrosigmoid approach, which is important for later CI, especially in single-sided deafness...
August 2018: Journal of Neurological Surgery. Part B, Skull Base
Kohei Yamahara, Koji Nishimura, Hideaki Ogita, Juichi Ito, Takayuki Nakagawa, Ichiro Furuta, Tomoko Kita, Koichi Omori, Norio Yamamoto
The hybrid or electric-acoustic stimulation cochlear implant is indicated in patients with a residual hearing at low frequencies. It provides electric and acoustic stimulation for compensating for high- and low-frequency sounds, respectively. However, the implantation procedure damages the cochlea, resulting in loss of the residual-hearing and diminished effects of the acoustic-hearing in several patients. To prevent hearing loss after implantation, corticosteroids have been used clinically although their effects are limited...
July 6, 2018: Hearing Research
Yuchen Xu, Chuan Luo, Fan-Gang Zeng, John C Middlebrooks, Harrison W Lin, Zheng You
OBJECTIVE: To improve the existing manually-assembled cochlear implant electrode arrays, a thin film electrode array (TFEA) was micro-fabricated to have a maximum electrode density of 15 sites along an 8-mm length, with each site having a 75 1.8-μm (diameter - height) disk electrode. METHODS: The micro-fabrication method adopted a sequence of photoresist transferring, lift-off, two-step oxygen plasma etching, and fuming nitric acid release to reduce lift-off complexity, protect the metal layer, and increase the release efficiency...
July 10, 2018: IEEE Transactions on Bio-medical Engineering
Christian Wrobel, Alexander Dieter, Antoine Huet, Daniel Keppeler, Carlos J Duque-Afonso, Christian Vogl, Gerhard Hoch, Marcus Jeschke, Tobias Moser
Cochlear implants partially restore hearing via direct electrical stimulation of spiral ganglion neurons (SGNs). However, spread of excitation from each electrode limits spectral coding. We explored the use of optogenetics to deliver spatially restricted and cell-specific excitation in the cochlea of adult Mongolian gerbils. Adeno-associated virus carrying the gene encoding the light-sensitive calcium translocating channelrhodopsin (CatCh) was injected into the cochlea of adult gerbils. SGNs in all cochlea turns showed stable and long-lasting CatCh expression, and electrophysiological recording from single SGNs showed that light stimulation up to few hundred Hertz induced neuronal firing...
July 11, 2018: Science Translational Medicine
Maike Vollmer
Bilateral cochlear implants (CIs) provide benefits for speech perception in noise and directional hearing, but users typically show poor sensitivity to interaural time differences (ITDs). Possible explanations for this deficit are deafness-induced degradations in neural ITD sensitivity, between-ear mismatches in electrode positions or activation sites, or differences in binaural brain circuits activated by electric versus acoustic stimulation. To identify potential limitations of electric ITD coding in the normal-hearing system, responses of single neurons in the dorsal nucleus of the lateral lemniscus and the inferior colliculus to ITDs of electric (biphasic pulses) and acoustic stimuli (noise, clicks, chirps, and tones) were recorded in normal-hearing gerbils of either sex...
June 29, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Noga Lipschitz, Gavriel D Kohlberg, Mario Zuccarello, Ravi N Samy
PURPOSE OF REVIEW: To review the current literature on the extended middle cranial fossa (xMCF) approach and to provide a comprehensive description of the relevant anatomy, indications, surgical technique, results, and complications. RECENT FINDINGS: The xMCF approach expands the surgical exposure provided by the sMCF approach, allowing access to the internal auditory canal, cerebellopontine angle, prepontine cistern, anterior petrous apex, petrous carotid artery, Meckel's cave, cavernous sinus, mid and upper clivus, and posterior lesions approaching the jugular foramen...
October 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
Shyam Sundar Krishnan, Pulak Nigam, Poonam Mohanty, Madabhushi Chakravarthy Vasudevan, Mohan Kameswaran
INTRODUCTION: Auditory brainstem implant (ABI), a standard technique in treatment of profound sensorineural hearing loss in patients with neurofibromatosis 2, is now being increasingly employed in children with congenital bilateral sensorineural hearing loss, as in Michele's deformity. A detailed knowledge of the relevant surgical anatomy of the lateral recess and its anatomical landmarks including the flocculus, the choroid plexus and the root entry zones of facial-vestibulocochlear and glossopharyngeal-vagus nerve complexes and their anatomical variants is mandatory, as it is the conduit for electrode array placement...
September 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Adrian L James, Peter R Dixon, Robert V Harrison
BACKGROUND: Cochlear nerve aplasia (CNA) may present with features of auditory neuropathy spectrum disorder (ANSD), having detectable otoacoustic emissions (OAE) but profound hearing loss. We propose that some children with CNA have a distinct form of afferent ANSD in which efferent cochlear nerve function can be detected using contralateral suppression of OAE. METHODS: Children were prospectively enrolled with MRI and auditory brainstem response evidence of unilateral CNA, a normal contralateral ear, and detectable OAE bilaterally...
2018: Audiology & Neuro-otology
Nadine Schart-Morén, Karin Hallin, Sumit K Agrawal, Hanif M Ladak, Per-Olof Eriksson, Hao Li, Helge Rask-Andersen
OBJECTIVES: Dehiscence between the cochlear otic capsule and the facial nerve canal is a rare and relatively newly described pathology. In cochlear implantation (CI), this dehiscence may lead to adverse electric facial nerve stimulation (FNS) already at low levels, rendering its use impossible. Here, we describe an assessment technique to foresee this complication. METHODS: Pre- and postoperative computed tomography (CT) scans and intraoperative electrically evoked auditory brainstem response (e-ABR) measurements were analyzed in two patients with cochlear-facial dehiscence (CFD)...
June 7, 2018: Cochlear Implants International
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