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Hospital throughput

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https://www.readbyqxmd.com/read/30007137/comparison-of-the-biofire-filmarray-respiratory-panel-seegene-anyplexii-rv16-and-argene-for-the-detection-of-respiratory-viruses
#1
Maurice Chan, Seok Hwee Koo, Boran Jiang, Pei Qi Lim, Thean Yen Tan
BACKGROUND: Respiratory infections are common reasons for hospital admission, and are associated with enormous economic burden due to significant morbidity and mortality. The wide spectrum of microbial agents underlying the pathology renders the diagnosis of respiratory infections challenging. Molecular diagnostics offer an advantage to the current serological and culture-based methods in terms of sensitivity, coverage, hands-on time, and time to results. OBJECTIVES: This study aimed to compare the clinical performance of three commercial kits for respiratory viral detection...
July 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30005137/management-of-organ-transplant-recipients-attending-a-high-throughput-skin-cancer-surgery-and-surveillance-clinic-in-queensland
#2
K Papier, L G Gordon, K Khosrotehrani, N Isbel, S Campbell, A Griffin, A C Green
BACKGROUND: The incidence of skin cancer in organ transplant recipients (OTRs) is very high due mainly to long-term immunosuppressive therapy. The problem is particularly severe for organ transplant recipients living in Queensland, Australia, resulting in significant mortality. OBJECTIVE: To describe the experience of the first dedicated outpatient high-throughput Transplant Skin Clinic in Queensland. METHODS: This prospective evaluation study was conducted at a newly established, outpatient transplant skin cancer surgery and surveillance clinic...
July 13, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29996183/-impact-on-the-intestinal-microbiota-of-early-antibiotic-treatment-in-preterm-neonates
#3
W W Zhu, Z L Li
Objective: To investigate the impact of early antibiotics treatment on intestinal microbiota in preterm infants. Methods: The cohort study was performed from January 2015 to June 2015 in Neonatal Intensive Care Unit of Peking University Third Hospital. A total of 33 preterm infants were enrolled, among whom 25 were antibiotics-exposure group, and 8 were non-exposure group. Serial stool samples were collected on the first day, 14th and 30th days of life and analyzed by high-throughput sequencing. In exposure group, intestinal microbiota was also analyzed at 8 months to 1 year of age...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29975508/digestion-free-analysis-of-peptides-from-30-year-old-formalin-fixed-paraffin-embedded-tissue-by-mass-spectrometry-imaging
#4
Martin R L Paine, Shane R Ellis, Dan Maloney, Ron M A Heeren, Peter Verhaert
Formalin-fixed neuroendocrine tissues from American cockroaches (Periplaneta americana) embedded in paraffin more than 30 years ago were recently analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), to reveal the histological localization of more than 20 peptide ions. These represented protonated, and other cationic species of, at least, 14 known neuropeptides. The characterization of peptides in such historical samples was made possible by a novel sample preparation protocol rendering the endogenous peptides readily amenable to MSI analysis...
July 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29972123/-clinical-phenotypes-and-a-genetic-analysis-of-patients-with-sotos-syndrome
#5
Min Zhao
Three boys aged 7-13 months visited the hospital due to unusual facies (prominent forehead, hypertelorism, or long mandible), motor developmental delay, and mental retardation. As for body length and head circumference, only one patient had a head circumference of >2 SD. Two patients had an advanced bone age, one had electroencephalographic abnormalities, and 3 had enlarged ventricles on head CT. The whole-genome microarray analysis showed the deletion of a copy with a size of 1.75 Mb in the chromosomal region 5q35...
June 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29953267/genetic-screening-for-bartter-syndrome-and-gitelman-syndrome-pathogenic-genes-among-individuals-with-hypertension-and-hypokalemia
#6
Minghui Bao, Jun Cai, Xinchun Yang, Wenjun Ma
PURPOSE: Bartter syndrome (BS) and Gitelman syndrome (GS) are hereditary diseases characterized by hypokalemia with decreased or normal blood pressure (BP). However, BS or GS patients who present with elevated BP levels have been increasingly reported recently. Therefore, this study aimed to investigate the presence of BS and GS among individuals with unexplained hypokalemia with hypertension in a clinical setting. METHODS: Patients presented with unexplained hypertension and hypokalemia admitted to Hypertension Center of Fuwai Hospital from November 2015 to February 2017 were enrolled...
June 28, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29952732/ibuprofen-biodegradation-by-hospital-municipal-and-distillery-activated-sludges
#7
Huang Chi-Yu, Fu Lu-Hsiang, Sung Meng-Hau, Huang Chun-Fu, Wu Jung-Pin, Kuo Hsion-Wen
Ibuprofen (IBU) has been considered as one of emergent pharmaceutical contaminants in environments due to its occurrences in natural water bodies. Some reports suggested that the IBU was biodegradable but details about biodegradation pathways and functional microbial community were still not fully clear. This study was aimed to assess IBU biodegradation using three different activated sludges (i.e., H: hospital, M: municipal, and D: distillery) with foci on surmising degradation pathway based on UPLC/Q-ToF/MS (ultra-performance liquid chromatography quadrupole time of flight mass spectrometry) analyses and concluding microbial community according to high-throughput sequencing for partial 16S rRNA gene...
June 28, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29927978/analysis-of-factors-associated-with-extended-recovery-time-after-colonoscopy
#8
Patrick C Eschenfeldt, Uri Kartoun, Curtis R Heberle, Chung Yin Kong, Norman S Nishioka, Kenney Ng, Sagar Kamarthi, Chin Hur
BACKGROUND & AIMS: A common limiting factor in the throughput of gastrointestinal endoscopy units is the availability of space for patients to recover post-procedure. This study sought to identify predictors of abnormally long recovery time after colonoscopy performed with procedural sedation. In clinical research, this type of study would be performed using only one regression modeling approach. A goal of this study was to apply various "machine learning" techniques to see if better prediction could be achieved...
2018: PloS One
https://www.readbyqxmd.com/read/29883434/critical-assessment-of-methods-to-quantify-biofilm-growth-and-evaluate-antibiofilm-activity-of-host-defence-peptides
#9
Evan F Haney, Michael J Trimble, John T Cheng, Quentin Vallé, Robert E W Hancock
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface. Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of hospital acquired infections and contribute to chronic infections. Troublingly, the bacteria within a biofilm are adaptively resistant to antibiotic treatment and it can take up to 1000 times more antibiotic to kill cells within a biofilm when compared to planktonic bacterial cells. Identifying and optimizing compounds that specifically target bacteria growing in biofilms is required to address this growing concern and the reported antibiofilm activity of natural and synthetic host defence peptides has garnered significant interest...
May 21, 2018: Biomolecules
https://www.readbyqxmd.com/read/29869218/genome-wide-screening-differential-long-non-coding-rnas-expression-profiles-discloses-its-roles-involved-in-ohss-development
#10
Haiyan Lin, Yu Li, Weijie Xing, Qi Qiu, Wenjun Wang, Qingxue Zhang
OBJECTIVE: To screen differentially expressed lncRNAs involved in OHSS. OHSS is defined as ovarian hyperstimulation syndrome. It is characterized as enlarged ovary and increased vascular permeability. DESIGN: Case-control study. SETTING: University-affiliated hospital. PATIENT(S): Patients with OHSS high risk (n = 30) and low risk (n = 30) were included in this study. INTERVENTION(S): None...
June 4, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29857424/patient-progression-a-hospital-wide-multi-disciplinary-data-driven-approach-to-moving-patients-safely-timely-efficiently
#11
Nancia T Odom, Mitch Babb, Laurie Velez, Zachary Cockerham
High emergency department length of stays (ED LOS), emergency department (ED) crowding and inefficient management of hospital patient throughput can negatively impact patient safety, patient care, and patient satisfaction [1]. In addition, patients who leave an ED without being seen by a medical provider can lead to potentially harmful outcomes. Duke Regional Hospital (DRH) set a strategic priority to improve hospital-wide patient progression. Our goals were to provide safe, efficient and timely movement of patients from admission to discharge...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29851650/the-impact-of-surgery-on-global-climate-a-carbon-footprinting-study-of-operating-theatres-in-three-health-systems
#12
Andrea J MacNeill, Robert Lillywhite, Carl J Brown
BACKGROUND: Climate change is a major global public health priority. The delivery of health-care services generates considerable greenhouse gas emissions. Operating theatres are a resource-intensive subsector of health care, with high energy demands, consumable throughput, and waste volumes. The environmental impacts of these activities are generally accepted as necessary for the provision of quality care, but have not been examined in detail. In this study, we estimate the carbon footprint of operating theatres in hospitals in three health systems...
December 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29849646/illumina-miseq-sequencing-for-preliminary-analysis-of-microbiome-causing-primary-endodontic-infections-in-egypt
#13
Sally Ali Tawfik, Marwa Mohamed Azab, Ali Abdellah Abdelrahman Ahmed, Dalia Mukhtar Fayyad
The use of high throughput next generation technologies has allowed more comprehensive analysis than traditional Sanger sequencing. The specific aim of this study was to investigate the microbial diversity of primary endodontic infections using Illumina MiSeq sequencing platform in Egyptian patients. Samples were collected from 19 patients in Suez Canal University Hospital (Endodontic Department) using sterile # 15K file and paper points. DNA was extracted using Mo Bio power soil DNA isolation extraction kit followed by PCR amplification and agarose gel electrophoresis...
2018: International Journal of Microbiology
https://www.readbyqxmd.com/read/29804715/comparing-the-effect-of-throughput-and-output-factors-on-emergency-department-crowding-a-retrospective-observational-cohort-study
#14
Malcolm B Doupe, Dan Chateau, Alecs Chochinov, Ellen Weber, Jennifer E Enns, Shelley Derksen, Joykrishna Sarkar, Michael Schull, Ricardo Lobato de Faria, Alan Katz, Ruth-Ann Soodeen
STUDY OBJECTIVE: This study compares how throughput and output factors affect emergency department (ED) median waiting room time. METHODS: Administrative health care use records were used to identify all daytime (8 am to 8 pm) visits made to adult EDs in Winnipeg, Canada, between April 1, 2012, and March 31, 2013. First, we measured the waiting room time (from patient registration until transfer into the ED) of each index visit (incoming patient). We then linked each index visit to a group of existing patients surrounding it and counted the number of existing patients engaged in throughput processes (radiographs, computed tomography [CT] scans, advanced diagnostic tests) and one output process (waiting to be hospitalized)...
May 24, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29792883/plasma-n-glycan-signatures-associate-with-features-of-inflammatory-bowel-diseases
#15
Florent Clerc, Mislav Novokmet, Viktoria Dotz, Karli R Reiding, Noortje de Haan, Guinevere S M Kammeijer, Hans Dalebout, Marco R Bladergroen, Frano Vukovic, Erdmann Rapp, Stephan R Targan, Gildardo Barron, Natalia Manetti, Anna Latiano, Dermot P B McGovern, Vito Annese, Gordan Lauc, Manfred Wuhrer
BACKGROUND & AIMS: Biomarkers are needed for early detection of Crohn's disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex post-translational modification of proteins that affects their structure and activity. We compared plasma N-glycosylation profiles between patients with CD or UC and healthy individuals (controls). METHODS: We analyzed the total plasma N-glycomes of 2635 patients with inflammatory bowel diseases and 996 controls by mass spectrometry with a linkage-specific sialic acid derivatization technique...
May 21, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29790443/improvement-of-laboratory-turnaround-time-using-lean-methodology
#16
Shradha Gupta, Sahil Kapil, Monica Sharma
Purpose The purpose of this paper is to discuss the implementation of lean methodology to reduce the turnaround time (TAT) of a clinical laboratory in a super speciality hospital. Delays in report delivery lead to delayed diagnosis increased waiting time and decreased customer satisfaction. The reduction in TAT will lead to increased patient satisfaction, quality of care, employee satisfaction and ultimately the hospital's revenue. Design/methodology/approach The generic causes resulting in increasing TAT of clinical laboratories were identified using lean tools and techniques such as value stream mapping (VSM), Gemba, Pareto Analysis and Root Cause Analysis...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29789905/pre-operative-mri-staging-of-endometrial-cancer-in-a-multicentre-cancer-network-can-we-match-single-centre-study-results
#17
N D Soneji, N Bharwani, A Ferri, V Stewart, A Rockall
OBJECTIVES: To evaluate the staging accuracy of magnetic resonance imaging (MRI) for endometrial cancer in daily practice over a 3-year period at a tertiary referral centre receiving scans from a large number of hospitals with varying protocols. To compare these daily practice results to published data from single-centre studies. METHODS: After ethical approval, MRI staging records for 270 studies from nine network and three centre hospitals were retrospectively collected and compared with final operative histopathology...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29783821/-clinical-and-genetic-analysis-of-eleven-pediatric-patients-with-alagille-syndrome
#18
L Guo, S T Zhao, Y Cheng, M Deng, H Li, Y Z Song, X R Cai, Q Zhou
Objective: To explore the clinical and molecular genetic features of patients with Alagille syndrome (AS). Methods: The clinical data of eleven pediatric patients, who were suspected to have AS at the Department of Pediatrics in the First Affiliated Hospital of Jinan University from August 2010 to March 2017, were collected and analyzed. Genomic DNA was extracted from peripheral blood leukocytes of the patients and their parents. For 5 patients collected before March 2006, all JAG1 exons and their flanking sequences were directly sequenced...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29779781/tag-array-gene-chip-rapid-diagnosis-anti-tuberculosis-drug-resistance-in-pulmonary-tuberculosis-a-feasibility-study
#19
Wenjie Wu, Peng Cheng, Jingtong Lyu, Zehua Zhang, Jianzhong Xu
OBJECTIVE: We developed a Tag Array chip for detecting first- and second-line anti tuberculosis drug resistance in pulmonary tuberculosis and compared the analytical performance of the gene chip to that of phenotypic drug susceptibility testing (DST). METHODS: From November 2011 to April 2016.234 consecutive culture-confirmed, clinically and imaging diagnosed patients with pulmonary tuberculosis from Southwest Hospital, Chongqing were enrolled into the study. Specimens collected during sputum or bronchoalveolar lavage fluid from the pulmonary tuberculosis patients were subjected to M...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29765082/pretreatment-drug-resistance-in-a-large-countrywide-ethiopian-hiv-1c-cohort-a-comparison-of-sanger-and-high-throughput-sequencing
#20
Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Samir Abdurahman, Gaetano Marrone, Ujjwal Neogi, Belete Tegbaru, Anders Sönnerborg
Baseline plasma samples of 490 randomly selected antiretroviral therapy (ART) naïve patients from seven hospitals participating in the first nationwide Ethiopian HIV-1 cohort were analysed for surveillance drug resistance mutations (sDRM) by population based Sanger sequencing (PBSS). Also next generation sequencing (NGS) was used in a subset of 109 baseline samples of patients. Treatment outcome after 6- and 12-months was assessed by on-treatment (OT) and intention-to-treat (ITT) analyses. Transmitted drug resistance (TDR) was detected in 3...
May 15, 2018: Scientific Reports
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