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https://www.readbyqxmd.com/read/29765082/pretreatment-drug-resistance-in-a-large-countrywide-ethiopian-hiv-1c-cohort-a-comparison-of-sanger-and-high-throughput-sequencing
#1
Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Samir Abdurahman, Gaetano Marrone, Ujjwal Neogi, Belete Tegbaru, Anders Sönnerborg
Baseline plasma samples of 490 randomly selected antiretroviral therapy (ART) naïve patients from seven hospitals participating in the first nationwide Ethiopian HIV-1 cohort were analysed for surveillance drug resistance mutations (sDRM) by population based Sanger sequencing (PBSS). Also next generation sequencing (NGS) was used in a subset of 109 baseline samples of patients. Treatment outcome after 6- and 12-months was assessed by on-treatment (OT) and intention-to-treat (ITT) analyses. Transmitted drug resistance (TDR) was detected in 3...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764576/-nipbl-gene-mutations-in-two-children-with-cornelia-de-lange-syndrome
#2
Yun-Jing Zhao, Hong-Wei Ma
Both children (one boy and one girl) experienced disease onset in infancy and visited the hospital due to growth retardation. They had unusual facies including thick hair, arched and confluent eyebrows, long and curly eyelashes, short nose, and micrognathia. Patient 1 had congenital heart disease (atrial septal defect and pulmonary stenosis) and special dermatoglyph (a single palmar crease). Patient 2 had cleft palate and moderate-to-severe deafness. Clinical features suggested Cornelia de Lange syndrome in both children...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29760847/decreased-nursing-staffing-adversely-affects-emergency-department-throughput-metrics
#3
Zachariah Ramsey, Joseph S Palter, John Hardwick, Jordan Moskoff, Errick L Christian, John Bailitz
Introduction: The effect of nurse staffing on emergency department (ED) efficiency remains a significant area of interest to administrators, physicians, and nurses. We believe that decreased nursing staffing adversely affects key ED throughput metrics. Methods: We conducted a retrospective observational review of our electronic medical record database from 1/1/2015 to 12/31/2015 at a high-volume, urban public hospital. We report nursing hours, door-to-discharge length of stay (LOS) and door-to-admit LOS, and percentage of patients who left without being seen (LWBS)...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29760842/appropriateness-of-extremity-magnetic-resonance-imaging-examinations-in-an-academic-emergency-department-observation-unit
#4
McKinley Glover, Ravi V Gottumukkala, Yadiel Sanchez, Brian J Yun, Theodore I Benzer, Benjamin A White, Anand M Prabhakar, Ali S Raja
Introduction: Emergency departments (ED) and hospitals face increasing challenges related to capacity, throughput, and stewardship of limited resources while maintaining high quality. Appropriate utilization of extremity magnetic resonance imaging (MRI) examinations within the emergency setting is not well known. Therefore, this study aimed to determine indications for and appropriateness of MRI of the extremities for musculoskeletal conditions in the ED observation unit (EDOU). Methods: We conducted this institutional review board-approved, retrospective study in a large, quaternary care academic center and Level I trauma center...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29759945/diagnosis-of-local-hepatic-tuberculosis-through-next-generation-sequencing-smarter-faster-and-better
#5
Jing-Wen Ai, Yang Li, Qi Cheng, Peng Cui, Hong-Long Wu, Bin Xu, Wen-Hong Zhang
BACKGROUND: A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology...
May 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29728385/effects-of-pslg-on-the-surface-movement-of-pseudomonas-aeruginosa
#6
Jingchao Zhang, Jing He, Chunhui Zhai, Luyan Z Ma, Lichuan Gu, Kun Zhao
PslG attracted a lot of attention recently due to its great potential abilities in inhibiting biofilms of Pseudomonas aeruginosa However, how PslG affects biofilm development still remains largely unexplored. Here, we focused on the surface motility of bacterial cells, which is critical for biofilm development. We studied the effect of PslG on bacterial surface movement in early biofilm development at a single-cell resolution by using a high-throughput bacterial tracking technique. The results showed that compared with no exogenous PslG addition, when PslG was added to the medium, bacterial surface movement was significantly faster by 4 ∼ 5 times, and was in a more random way with no clear preferred direction...
May 4, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29706114/service-delivery-innovation-for-hospital-emergency-management-using-rich-organizational-modelling
#7
Yogit Dhakal, Moshiur Bhuiyan, Pwc Prasad, Aneesh Krishna
The purpose of this article is to identify and assess service delivery issues within a hospital emergency department and propose an improved model to address them. Possible solutions and options to these issues are explored to determine the one that best fits the context. In this article, we have analysed the emergency department's organizational models through i* strategic dependency and rational modelling technique before proposing updated models that could potentially drive business process efficiencies...
April 1, 2018: Health Informatics Journal
https://www.readbyqxmd.com/read/29675400/simultaneous-detection-of-key-bacterial-pathogens-related-to-pneumonia-and-meningitis-using-multiplex-pcr-coupled-with-mass-spectrometry
#8
Chi Zhang, Leshan Xiu, Yan Xiao, Zhengde Xie, Lili Ren, Junping Peng
Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To solve this problem, we developed and validated a 12-plex PCR coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method (bacterial pathogen-mass spectrometry, BP-MS) that can be used to simultaneously screen for 11 key bacterial pathogens related to pneumonia and meningitis...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29674366/can-interprofessional-teamwork-reduce-patient-throughput-times-a-longitudinal-single-centre-study-of-three-different-triage-processes-at-a-swedish-emergency-department
#9
Jenny Liu, Italo Masiello, Sari Ponzer, Nasim Farrokhnia
OBJECTIVE: To determine the impact on emergency department (ED) throughput times and proportion of patients who leave without being seen by a physician (LWBS) of two triage interventions, where comprehensive nurse-led triage was first replaced by senior physician-led triage and then by interprofessional teamwork. DESIGN: Single-centre before-and-after study. SETTING: Adult ED of a Swedish urban hospital. PARTICIPANTS: Patients arriving on weekdays 08:00 to 21:00 during three 1-year periods in the interval May 2012 to November 2015...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29670890/correlations-between-microbial-communities-in-stool-and-clinical-indicators-in-patients-with-metabolic-syndrome
#10
Lang Lin, Zai-Bo Wen, Dong-Jiao Lin, Jiang-Ting Dong, Jie Jin, Fei Meng
AIM: To analyze the bacterial community structure and distribution of intestinal microflora in people with and without metabolic syndrome and combined these data with clinical indicators to determine relationships between selected bacteria and metabolic diseases. METHODS: Faecal samples were collected from 20 patients with metabolic syndrome and 16 controls at Cangnan People's Hospital, Zhejiang Province, China. DNA was extracted and the V3-V4 regions of the 16S rRNA genes were amplified for high throughput sequencing...
April 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29669328/tagging-functional-polymorphism-in-3-untranslated-region-of-methylene-tetrahydrofolate-reductase-and-risk-of-ischemic-stroke
#11
Jiajia Shi, Wei He, Yu Wang, Jiajia Hua
BACKGROUND/AIMS: The association between genetic polymorphisms in the exon or untranslated region of the methylenetetrahydrofolate reductase gene (MTHFR) and the risk of human ischemic stroke (IS) has been well-documented. In this study, we focused on a polymorphism previously screened by high-throughput analysis and on its potential function in patients with IS Methods: This hospital-based case-control study was conducted in 400 patients and 400 healthy volunteers. Genotyping was conducted using TaqMan probes...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29652493/reprogramming-probiotic-lactobacillus-reuteri-as-a-biosensor-for-staphylococcus-aureus-derived-aip-i-detection
#12
David Lubkowicz, Chun Loong Ho, In Young Hwang, Wen Shan Yew, Yung Seng Lee, Matthew Wook Chang
Gram-positive Staphylococcus aureus infection that results in pneumonia, urinary tract infection, and in severe cases, sepsis, has recently been classified as a serious threat to public health. Rapid and cost-effective detection of these infections are costly and time-consuming. Here, we present probiotic lactic acid bacteria engineered to detect autoinducer peptide-I (AIP-I), a quorum sensing molecule produced by Staphylococcus sp. during pathogenesis. We achieved this by adapting the well-characterized agr quorum sensing ( agrQS) from Staphylococcus aureus into Lactobacillus reuteri...
April 13, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29643071/facilitating-the-timely-discharge-of-well-newborns-by-using-quality-improvement-methods
#13
Nicole T Rochester, Laurie P Banach, Wendy Hoffner, Deena Zeltser, Phyllis Lewis, Elizabeth Seelbach, Sandra Cuzzi
BACKGROUND AND OBJECTIVES: Discharges are a key driver of hospital throughput. Our pediatric hospitalist team sought to improve newborn nursery throughput by increasing the percentage of newborns on our service with a discharge order by 11 am. We hypothesized that implementing a discharge checklist would result in earlier discharge times for newborns who met discharge criteria. METHODS: We identified barriers to timely discharge through focus groups with key stakeholders, chart reviews, and brainstorming sessions...
April 11, 2018: Pediatrics
https://www.readbyqxmd.com/read/29596412/development-and-evaluation-of-antibody-capture-immunoassays-for-detection-of-lassa-virus-nucleoprotein-specific-immunoglobulin-m-and-g
#14
Martin Gabriel, Donatus I Adomeh, Jacqueline Ehimuan, Jennifer Oyakhilome, Emmanuel O Omomoh, Yemisi Ighodalo, Thomas Olokor, Kofi Bonney, Meike Pahlmann, Petra Emmerich, Michaela Lelke, Linda Brunotte, Stephan Ölschläger, Corinna Thomé-Bolduan, Beate Becker-Ziaja, Carola Busch, Ikponmwonsa Odia, Ephraim Ogbaini-Emovon, Peter O Okokhere, Sylvanus A Okogbenin, George O Akpede, Herbert Schmitz, Danny A Asogun, Stephan Günther
BACKGROUND: The classical method for detection of Lassa virus-specific antibodies is the immunofluorescence assay (IFA) using virus-infected cells as antigen. However, IFA requires laboratories of biosafety level 4 for assay production and an experienced investigator to interpret the fluorescence signals. Therefore, we aimed to establish and evaluate enzyme-linked immunosorbent assays (ELISA) using recombinant Lassa virus nucleoprotein (NP) as antigen. METHODOLOGY/PRINCIPAL FINDINGS: The IgM ELISA is based on capturing IgM antibodies using anti-IgM, and the IgG ELISA is based on capturing IgG antibody-antigen complexes using rheumatoid factor or Fc gamma receptor CD32a...
March 29, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29577086/katharoseq-enables-high-throughput-microbiome-analysis-from-low-biomass-samples
#15
Jeremiah J Minich, Qiyun Zhu, Stefan Janssen, Ryan Hendrickson, Amnon Amir, Russ Vetter, John Hyde, Megan M Doty, Kristina Stillwell, James Benardini, Jae H Kim, Eric E Allen, Kasthuri Venkateswaran, Rob Knight
Microbiome analyses of low-biomass samples are challenging because of contamination and inefficiencies, leading many investigators to employ low-throughput methods with minimal controls. We developed a new automated protocol, KatharoSeq (from the Greek katharos [clean]), that outperforms single-tube extractions while processing at least five times as fast. KatharoSeq incorporates positive and negative controls to reveal the whole bacterial community from inputs of as few as 50 cells and correctly identifies 90...
May 2018: MSystems
https://www.readbyqxmd.com/read/29559366/evaluation-of-a-micro-nanofluidic-chip-platform-for-the-high-throughput-detection-of-bacteria-and-their-antibiotic-resistance-genes-in-post-neurosurgical-meningitis
#16
Guojun Zhang, Guanghui Zheng, Yan Zhang, Ruimin Ma, Xixiong Kang
Post-neurosurgical meningitis (PNM) is one of the most severe hospital-acquired infections (HAI) worldwide, and a large number of pathogens, especially those possessing multi-resistance genes, are related to these infections. Existing methods for detecting bacteria and measuring their response to antibiotics lack sensitivity and stability, and laboratory-based detection methods are inconvenient, which require at least 24h to complete. Rapid identification of bacteria and the determination of their susceptibility to antibiotics are urgently needed, in order to combat the emergence of multi-resistant bacterial strains...
March 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29552955/the-impact-of-opening-a-medical-step-down-unit-on-medically-critically-ill-patient-outcomes-and-throughput-a-difference-in-differences-analysis
#17
Hayley B Gershengorn, Carri W Chan, Yunchao Xu, Hanxi Sun, Ronni Levy, Mor Armony, Michelle N Gong
OBJECTIVE: To understand the impact of adding a medical step-down unit (SDU) on patient outcomes and throughput in a medical intensive care unit (ICU). DESIGN: Retrospective cohort study. SETTING: Two academic tertiary care hospitals within the same health-care system. PATIENTS: Adults admitted to the medical ICU at either the control or intervention hospital from October 2013 to March 2014 (preintervention) and October 2014 to March 2015 (postintervention)...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29550711/electro-peroxone-pretreatment-for-enhanced-simulated-hospital-wastewater-treatment-and-antibiotic-resistance-genes-reduction
#18
He-Shan Zheng, Wan-Qian Guo, Qu-Li Wu, Nan-Qi Ren, Jo-Shu Chang
Hospital wastewater is one of the possible sources responsible for antibiotic resistant bacteria spread into the environment. This study proposed a promising strategy, electro-peroxone (E-peroxone) pretreatment followed by a sequencing batch reactor (SBR) for simulated hospital wastewater treatment, aiming to enhance the wastewater treatment performance and to reduce antibiotic resistance genes production simultaneously. The highest chemical oxygen demand (COD) and total organic carbon (TOC) removal efficiency of 94...
March 15, 2018: Environment International
https://www.readbyqxmd.com/read/29543065/day-case-holmium-laser-enucleation-of-the-prostate-feasibility-safety-and-predictive-factors
#19
S-M Lee, K Gordon, R McMillan, F Crystal, P Acher
Introduction Transurethral resection of the prostate has remained the most common operation for bladder outlet obstruction in the UK, but it is associated with potential morbidity and median two-day length of hospital stay. Holmium laser enucleation of the prostate (HoLEP) provides an alternative procedure. Provision of day-case HoLEP would improve patient care through increased efficiency. We assessed the feasibility and safety of day-case HoLEP and examined predictive factors for increased length of hospital stay...
March 15, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29535086/validity-of-the-japan-acuity-and-triage-scale-in-adults-a-cohort-study
#20
Akira Kuriyama, Tetsunori Ikegami, Toshie Kaihara, Toshio Fukuoka, Takeo Nakayama
OBJECTIVE: The Japan Acuity and Triage Scale (JTAS) was developed based on Canadian Triage and Acuity Scale in 2012 and has been implemented in many Japanese EDs. We assessed the validity of JTAS by examining the association between JTAS triage levels and throughput and clinical outcomes in adult patients. METHODS: We conducted a retrospective analysis of prospectively collected clinical data in the ED of a Japanese tertiary-care hospital. We included self-presenting patients who were ≥16 years of age and triaged between June 2013 and May 2014...
March 13, 2018: Emergency Medicine Journal: EMJ
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