Jordi Del-Pozo-Rodriguez, Peggy Tilly, Romain Lecat, Hugo Rolando Vaca, Laureline Mosser, Till Balla, Marina Vitoria Gomes, Elizabeth Ramos-Morales, Elena Brivio, Thalia Salinas-Giégé, Grace VanNoy, Eleina M England, Alysia Kern Lovgren, Melanie O'Leary, Maya Chopra, Dustin Gable, Aisha Alnuzha, Mona Kamel, Nihal Almenabawy, Anne O'Donnell-Luria, Jennifer E Neil, Joseph G Gleeson, Christopher A Walsh, Nour Elkhateeb, Laila Selim, Siddharth Srivastava, Danny D Nedialkova, Laurence Drouard, Christophe Romier, Efil Bayam, Juliette D Godin
The ADAT2/ADAT3 complex catalyzes the adenosine to inosine modification at the wobble position of eukaryotic tRNAs. Mutations in ADAT3 , the catalytically inactive subunit of the ADAT2/ADAT3 complex, have been identified in patients presenting with severe neurodevelopmental disorders (NDDs). Yet, the physiological function of ADAT2/ADAT3 complex during brain development remains totally unknown. Here we showed that maintaining a proper level of ADAT2/ADAT3 catalytic activity is required for correct radial migration of projection neurons in the developing mouse cortex...
March 5, 2024: medRxiv