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Runxia Wang, Haihong Liu, Fei Feng, Fang Yan
In this study, the authors first discuss the existence of Bogdanov-Takens and triple zero singularity of a five neurons neutral bidirectional associative memory neural networks model with two delays. Then, by utilising the centre manifold reduction and choosing suitable bifurcation parameters, the second-order and the third-order normal forms of the Bogdanov-Takens bifurcation for the system are obtained. Finally, the obtained normal form and numerical simulations show some interesting phenomena such as the existence of a stable fixed point, a pair of stable non-trivial equilibria, a stable limit cycles, heteroclinic orbits, homoclinic orbits, coexistence of two stable non-trivial equilibria and a stable limit cycles in the neighbourhood of the Bogdanov-Takens bifurcation critical point...
December 2017: IET Systems Biology
Kelly J Domesle, Qianru Yang, Thomas S Hammack, Beilei Ge
Loop-mediated isothermal amplification (LAMP) has emerged as a promising alternative to PCR for pathogen detection in food testing and clinical diagnostics. This study aimed to validate a Salmonella LAMP method run on both turbidimetry (LAMP I) and fluorescence (LAMP II) platforms in representative animal food commodities. The U.S. Food and Drug Administration (FDA)'s culture-based Bacteriological Analytical Manual (BAM) method was used as the reference method and a real-time quantitative PCR (qPCR) assay was also performed...
October 18, 2017: International Journal of Food Microbiology
Molly Mishler Thomason, Natasha Poulopoulos, Eve Nguyen, Amitha Prasad Gumidyala, Stacy A Kahn, Rachel N Greenley
Low adherence is a pervasive issue among youth with inflammatory bowel diseases (IBD), yet our understanding of perceived adherence barriers is hampered by a lack of validated instruments. This study sought to address this by evaluating the reliability and predictive validity of the Beliefs About Medication Scale (BAMS) among youth with IBD. Seventy-six youth (ages 11-18) with IBD who were prescribed a daily oral IBD medication completed baseline ratings of perceived adherence barriers via the BAMS. Parents provided information about patient demographic and disease factors...
September 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
Rakesh Sikdar, Janine H Peterson, D Eric Anderson, Harris D Bernstein
The Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folded substrates. Here, to distinguish between these two possibilities, we analyze the biogenesis of UpaG, a trimeric autotransporter adhesin (TAA). TAAs consist of three identical subunits that together form a single β-barrel domain and an extracellular coiled-coil ("passenger") domain...
November 3, 2017: Nature Communications
Peter Schweitzer, Olga Povoroznyuk, Sigrid Schiesser
Public and academic discourses about the Polar regions typically focus on the so-called natural environment. While, these discourses and inquiries continue to be relevant, the current article asks the question how to conceptualize the on-going industrial and infrastructural build-up of the Arctic. Acknowledging that the "built environment" is not an invention of modernity, the article nevertheless focuses on large-scale infrastructural projects of the twentieth century, which marks a watershed of industrial and infrastructural development in the north...
January 2, 2017: Polar J
Tonya D Andreeva, Svetla D Petrova, Kirilka Mladenova, Veselina Moskova-Doumanova, Tanya Topouzova-Hristova, Yulia Petseva, Nikola Mladenov, Konstantin Balashev, Zdravko Lalchev, Jordan A Doumanov
Bestrophinopathies are ocular diseases caused by mutations in the human bestrophin-1 (hBest1) - transmembrane Ca(2+)-activated chloride channel protein, mainly expressed in the retinal pigment epithelium (RPE) cells. hBest1 is also an important transporter for neurotransmitters such as glutamate (Glu) and γ-aminobutyric acid (GABA) in the nervous system. Recently, a new biological role of hBest1, related to its possible involvement in the pathology of brain diseases (Alzheimer's, Parkinson's disease) has been proposed...
October 18, 2017: Colloids and Surfaces. B, Biointerfaces
C Sowmiya, R Raja, Jinde Cao, G Rajchakit, Ahmed Alsaedi
This paper is concerned with the problem of enhanced results on robust finite-time passivity for uncertain discrete-time Markovian jumping BAM delayed neural networks with leakage delay. By implementing a proper Lyapunov-Krasovskii functional candidate, the reciprocally convex combination method together with linear matrix inequality technique, several sufficient conditions are derived for varying the passivity of discrete-time BAM neural networks. An important feature presented in our paper is that we utilize the reciprocally convex combination lemma in the main section and the relevance of that lemma arises from the derivation of stability by using Jensen's inequality...
2017: Advances in difference equations
Jonathan D Monroe, Jillian S Breault, Lauren E Pope, Catherine E Torres, Tewaldemedhine B Gebrejesus, Christopher E Berndsen, Amanda R Storm
The Arabidopsis thaliana genome contains nine β-amylase (BAM) genes, some of which play important roles in starch hydrolysis. However, little is known about BAM2, a plastid-localized enzyme reported to have extremely low catalytic activity. Using conservation of intron positions, we determined that the nine Arabidopsis BAM genes fall into two distinct subfamilies. A similar pattern was found in each major lineage of land plants suggesting that these subfamilies diverged prior to the origin of land plants. Moreover, phylogenetic analysis indicated that BAM2 is the ancestral member of one of these subfamilies...
October 24, 2017: Plant Physiology
Mingzhe Liu, Stefan Jevtic, Kelly Markham-Coultes, Nicholas P K Ellens, Meaghan A O'Reilly, Kullervo Hynynen, Isabelle Aubert, JoAnne McLaurin
Amyloid-beta peptide (Aβ) plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we explored the use of a combination treatment to reduce amyloid load through microglial phagocytosis in a mouse model of AD. We hypothesized that using an initial treatment of magnetic resonance image guided focused ultrasound (MRIgFUS) to transiently increase the blood-brain barrier (BBB) permeability and enhance the delivery of an Aβ-antibody (BAM-10), followed by scyllo-inositol treatment would result in accelerated clearance...
October 21, 2017: Brain Research
Chaille T Webb, Dilini Chandrapala, Siti Nurbaya Oslan, Rebecca S Bamert, Rhys D Grinter, Rhys A Dunstan, Rebecca J Gorrell, Jiangning Song, Richard A Strugnell, Trevor Lithgow, Terry Kwok
Helicobacter pylori is a gram-negative bacterial pathogen that chronically inhabits the human stomach. To survive and maintain advantage, it has evolved unique host-pathogen interactions mediated by Helicobacter-specific proteins in the bacterial outer membrane. These outer membrane proteins (OMPs) are anchored to the cell surface via a C-terminal β-barrel domain, which requires their assembly by the β-barrel assembly machinery (BAM). Here we have assessed the complexity of the OMP C-terminal β-barrel domains employed by H...
October 21, 2017: MicrobiologyOpen
Kaisa Kerminen, Romain Le Moël, Vilhelmiina Harju, Merja H Kontro
Pesticides leaching from soil to surface and groundwater are a global threat for drinking water safety, as no cleaning methods occur for groundwater environment. We examined whether peat, compost-peat-sand (CPS) mixture, NH4NO3, NH4NO3 with sodium citrate (Na-citrate), and the surfactant methyl-β-cyclodextrin additions enhance atrazine, simazine, hexazinone, dichlobenil, and the degradate 2,6-dichlorobenzamide (BAM) dissipations in sediment slurries under aerobic and anaerobic conditions, with sterilized controls...
October 17, 2017: Science of the Total Environment
Brent S Pedersen, Ryan L Collins, Michael E Talkowski, Aaron R Quinlan
The BAM1 and CRAM2 formats provide a supplementary linear index that facilitates rapid access to sequence alignments in arbitrary genomic regions. Comparing consecutive entries in a BAM or CRAM index allows one to infer the number of alignment records per genomic region for use as an effective proxy of sequence depth in each genomic region. Based on these properties, we have developed indexcov, an efficient estimator of whole-genome sequencing coverage to rapidly identify samples with aberrant coverage profiles, reveal large scale chromosomal anomalies, recognize potential batch effects, and infer the sex of a sample...
September 18, 2017: GigaScience
Chunying Shi, Wei Chen, Bing Chen, Tao Shan, Weisheng Jia, Xianglin Hou, Longkun Li, Gang Ye, Jianwu Dai
Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (half of the entire bladder was resected)...
October 19, 2017: Biomaterials Science
Robbins Puthenveetil, Sanjiv Kumar, Melissa J Caimano, Abhishek Dey, Arvind Anand, Olga Vinogradova, Justin D Radolf
The major outer sheath protein (MOSP) is a prominent constituent of the cell envelope of Treponema denticola (TDE) and one of its principal virulence determinants. Bioinformatics predicts that MOSP consists of N- and C-terminal domains, MOSP(N) and MOSP(C). Biophysical analysis of constructs refolded in vitro demonstrated that MOSP(C), previously shown to possess porin activity, forms amphiphilic trimers, while MOSP(N) forms an extended hydrophilic monomer. In TDE and E. coli expressing MOSP with a PelB signal sequence (PelB-MOSP), MOSP(C) is OM-embedded and surface-exposed, while MOSP(N) resides in the periplasm...
October 16, 2017: Scientific Reports
Ana Catarina Alves, Cláudia Nunes, José Lima, Salette Reis
The anthracyclines daunorubicin and doxorubicin are widely used antineoplastic agents due to their therapeutic activity against a broad variety of human cancers. Although, the classical model to explain anthracyclines' cytotoxicity has been based in the direct interference with nucleic acid function, evidence suggests that the plasma membrane is also involved in the drug's mechanism of action. In this work, the interaction of these drugs with two-dimensional membrane models were studied in order to gain further insights at the molecular level regarding anthracyclines membrane interactions...
October 3, 2017: Colloids and Surfaces. B, Biointerfaces
María de la O Leyva-Pérez, Jaime Jiménez-Ruiz, Carmen Gómez-Lama Cabanás, Antonio Valverde-Corredor, Juan B Barroso, Francisco Luque, Jesús Mercado-Blanco
Verticillium wilt of olive (VWO) is one of the most serious biotic constraints for this tree crop. Our knowledge of the genetics of the tolerance/resistance to this disease is very limited. Here we show that tolerance of the cv Frantoio relies on both basal and early pathogen-induced differential transcriptomic responses. A comparative transcriptomic analysis (RNA-seq) was conducted in root tissues of cvs Frantoio (VWO-tolerant) and Picual (VWO-susceptible). RNA samples originated from roots of inoculated olive plants during the early infection stages by Verticillium dahliae (highly virulent, defoliating pathotype)...
October 12, 2017: New Phytologist
Leandro de Araújo Lima, Kai Wang
BACKGROUND: The use of high-throughput sequencing data has improved the results of genomic analysis due to the resolution of mapping algorithms. Although several tools for copy-number variation calling in whole genome sequencing have been published, the noisy nature of sequencing data is still a limitation for accuracy and concordance among such tools. To assess the performance of PennCNV original algorithm for array data in whole genome sequencing data, we processed mapping (BAM) files to extract coverage, representing log R ratio (LRR) of signal intensity, and B allele frequency (BAF)...
October 3, 2017: BMC Bioinformatics
Faiza Benahmed, Hua Wang, Junia Jean-Gilles Beaubrun, Gopal R Gopinath, Chorng-Ming Cheng, Darcy E Hanes, Thomas S Hammack, Mark Rasmussen, Maureen K Davidson
Because some significant outbreaks of human salmonellosis have been traced to contaminated animal feed, the rapid and efficient detection of Salmonella in feed is essential. However, the current U.S. Food and Drug Administration Bacteriological Analytical Manual (BAM) culture method that uses lactose broth as a preenrichment medium has not reliably supported the results of real-time PCR assays for certain foods. We evaluated the BAM culture method and a quantitative real-time PCR (qPCR) assay using two preenrichment media, modified buffered peptone water and lactose broth, to detect Salmonella enterica subsp...
October 4, 2017: Journal of Food Protection
Neda Mohammadinia, Mohammad Ali Rezaei, Foroozan Atashzadeh-Shoorideh
BACKGROUND: With the increasing number of elderly, especially in recent decades, transfer to nursing homes and the number of centers has also increased but experiences and problems of elders in these centers is less considered. So, the goal of this study is to explore the Elderly peoples' experiences of nursing homes. METHODS: The current research was performed using a phenomenological approach in 2016. Participation in the study is comprised of the elderly residents in a nursing home in Bam city who were selected based on an objective-oriented approach...
August 2017: Electronic Physician
Peng Yang, Marpe Bam, Parasmani Pageni, Tianyu Zhu, Yung Pin Chen, Mitzi Nagarkatti, Alan W Decho, Chuanbing Tang
Bacterial infections, particularly by Gram-negative pathogens, have become a serious threat to global healthcare due to the diminishing effectiveness of existing antibiotics. We report a nontraditional therapy to combine three components in one macromolecular system, in which boronic acid adheres to peptidoglycan or lipopolysaccharide via boron-polyol based boronolectin chemistry, cationic metal polymer frameworks interact with negatively charged cell membranes, and β-lactam antibiotics are reinstated with enhanced vitality to attack bacteria via evading the detrimental enzyme-catalyzed hydrolysis...
November 10, 2017: ACS Infectious Diseases
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