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Sen Li, Qian Liu, Jin Wang, Xueqin Pang, Youpeng Zhang, Yongbiao Cheng, Yao Fu, Jialun Guo, Yong Tang, Hanqing Zeng, Yali Yang, Zhaohui Zhu
The recurrence rates after varicocelectomy vary from 0.9% to 32.2%, especially for patients with the left renal vein entrapment (LRVE). This study aims to study the association between LRVE and varicocele recurrence, and to find the risk factors of LRVE. With the design of a cohort study, we included 3042 varicocele patients who would undergo modified inguinal microscope-assisted varicocelectomy (MHMV). 858 (28.21%) patients with LRVE were as the study group, and 2184 (71.79%) patients without LRVE were as the control group...
July 12, 2018: Scientific Reports
Yin-Wei Chen, Yong-Hua Niu, Dao-Qi Wang, Hao Li, Gaurab Pokhrel, Hao Xu, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Varicocele is one of the common correctable causes of male infertility. Recent studies have demonstrated varicocelectomy in males with abnormal semen parameters was associated with better fertility outcome, but the effect of adjuvant drug therapy after varicocelectomy on fertility outcome in patients with varicocele-associated infertility remains undefined. Hence, the present meta-analysis was performed to assess the efficacy of adjuvant drug therapy after varicocelectomy. The protocol was registered with PROSPERO (No...
July 11, 2018: Andrologia
Phil Vu Bach, Neal Patel, Bobby B Najari, Clara Oromendia, Ryan Flannigan, Robert Brannigan, Marc Goldstein, Jim C Hu, James A Kashanian
OBJECTIVE: To assess changes in the practice patterns of urologists performing male infertility procedures (vasal reconstruction, sperm retrieval, varicocelectomy) from 2004 to 2015 in the United States. DESIGN: Examination of self-reported procedural volumes from urologists undergoing certification and recertification using case log data provided by the American Board of Urology. The study period was stratified into early (2004-2007) and recent (2012-2015) time periods...
July 1, 2018: Fertility and Sterility
Daxue Tian, Wei Huang, Huilei Yan, Huantao Zong, Yong Zhang
Varicocelectomy can improve the function of testicular Leydig cell for patients with varicocele. We carried out a systematic review and meta-analysis to assess effect of varicocelectomy on serum FSH and LH levels for patients with varicocele. A literature review was performed to identify all published randomized preoperation-postoperation clinical trials of assessing serum FSH and LH levels before and after varicocelectomy. The search included the following databases: PUBMED and EMBASE. The reference lists of retrieved studies were also investigated...
June 2018: Indian Journal of Surgery
Serajoddin Vahidi, Mohammadreza Moein, Ali Nabi, Nima Narimani
It seems that varicocele play a role in male infertility, as such, their prevalence increases from 15% in the normal population to 80% in secondary infertility subjects. Varicoceles may have negative effects on semen quality. Our goal was to assess the effects of microsurgical varicocelectomy on semen analysis and sperm functional tests in men with different grades of varicoceles. Thirty infertile men with different grades of varicoceles (grades 1 to 3) were enrolled in our study. Semen quality was assessed by semen analysis according to the WHO guideline (WHO, 1999) and four different sperm functional tests (aniline blue, toluidine blue, chromomycin A3 and TUNEL test) were carried out before and 3 months after microsurgical varicocelectomy (M-varicocelectomy)...
June 25, 2018: Andrologia
Craig Niederberger
No abstract text is available yet for this article.
June 2018: Journal of Urology
Sunghyun Paick, Woo Suk Choi
Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain. The probable mechanisms for pain include compression of the surrounding neural fibers by the dilated venous complex, elevated testicular temperature, increased venous pressure, hypoxia, oxidative stress, hormonal imbalances, and the reflux of toxic metabolites of adrenal or renal origin. Testicular pain associated with varicoceles is typically described as a dull, aching, or throbbing pain in the testicle, scrotum, or groin; rarely, it can be acute, sharp, or stabbing...
May 16, 2018: World Journal of Men's Health
Taylor P Kohn, Samuel J Ohlander, Jake S Jacob, Tina M Griffin, Larry I Lipshultz, Alexander W Pastuszak
PURPOSE OF REVIEW: Current guidelines recommend against surgical repair of subclinical varicoceles (SCVs) for infertility; several studies demonstrate mixed fertility results after SCV correction. To determine whether surgical correction of SCV improves semen parameters and/or reproductive outcomes, we performed a systematic review and meta-analysis. Seven biomedical literature databases were searched through January 2018 for studies that assessed reproductive outcomes and/or change in semen parameters in men with corrected SCV compared to either (1) uncorrected SCV or (2) corrected clinical varicocele...
May 17, 2018: Current Urology Reports
Chirag Gupta, Arun Chinchole, Rupin Shah, Hemant Pathak, Deepa Talreja, Ankit Kayal
Purpose: Many studies have shown improved semen parameters after varicocele surgery; however, the benefit in terms of improved pregnancy rates and live births is still disputed in cases of severe oligoasthenozoospermia (OAS). The present study evaluated the outcome of microscopic subinguinal varicocelectomy in terms of the spontaneous pregnancy rate in patients with severe OAS. Materials and Methods: This was a retrospective, observational, analytic study of 56 men with OAS who underwent microscopic varicocelectomy at our center between 2008 and 2015...
May 2018: Investigative and Clinical Urology
X-L Lu, J-J Liu, J-T Li, Q-A Yang, J-M Zhang
In this study, we aimed at investigating the impact of melatonin supplementation on semen parameters, hormonal profile and total antioxidant capacity after varicocelectomy. Infertile male patients who were diagnosed with varicocele and underwent subinguinal varicocelectomy were included in the study. After performing subinguinal varicocelectomy, the patients were randomised into two groups: 27 receiving melatonin for 3 months and 27 as the placebo-controlled group receiving placebo for 3 months. The pre-operative parameters of semen analyses, hormonal profile and seminal oxidative stress status of both groups were compared with those of post-operative parameters...
May 8, 2018: Andrologia
M Raghavendran, A Venugopal, G Kiran Kumar
BACKGROUND: Acute scrotal pain has various causes. Testicular torsion, torsion of appendages and Epididymo-orchitis are common causes, while varicocele thromboses are a rare cause. Varicocele thromboses can occur post operatively or spontaneously. Five cases of post-operative and five cases of spontaneous thromboses have been described till date. The traditional advice in the management of thrombosed varicocele has been to manage it conservatively in all patients by drugs and scrotal support with little description of the surgical treatment...
May 8, 2018: BMC Urology
Yun-Long Liu, Xian-En Gu, Xiao-Yi Zhang, De-Zhong Liu, Lian Zou
Objective: To investigate the factors influencing the postoperative resolution of varicocele-associated scrotal pain. METHODS: Using the keywords "varicocele", "testicular pain", "scrotal pain", "painful varicocele", "ligation", and "varicocelectomy", we searched the PubMed, Embase, Cochrane Collaboration's Database, CNKI, Wanfang, and VIP Database up to October 2016 for the studies relating to surgical treatment of varicocele-associated scrotal pain...
June 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
Mehmet G Sönmez, Ahmet H Haliloğlu
Objective: In this review, we investigate the advantage of varicocele repair prior to assisted reproductive technologies (ART) for infertile couples and provide cost analysis information. Materials and methods: We searched the following electronic databases: PubMed, Medline, Excerpta Medica Database (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL). The following search strategy was modified for the various databases and search engines: 'varicocele', 'varicocelectomy', 'varicocele repair', 'ART', ' in vitro fertilisation (IVF)', 'intracytoplasmic sperm injection (ICSI)'...
March 2018: Arab Journal of Urology
Ahmed M Al-Kandari, Abdulnasser Khudair, Abdelghaffar Arafa, Fouad Zanaty, Ahmed Ezz, Mohamed El-Shazly
Objective: To evaluate the detailed vascular anatomy of the spermatic cord during subinguinal microscopic varicocelectomy and to assess the outcome of the cases with regard to varicocele recurrence and hydrocele formation. Patients and methods: In all, 100 varicocele cases including 74 left-sided and 26 bilateral, comprising 126 spermatic cord units with clinically palpable varicoceles underwent microscopic subinguinal varicocelectomy. Detailed description of vascular anatomy of the spermatic cords was reported...
March 2018: Arab Journal of Urology
Scott D Lundy, Edmund S Sabanegh
Despite being first described two thousand years ago, the varicocele remains a controversial multifaceted disease process with numerous biological consequences including infertility, hypogonadism, and chronic orchidalgia. The underlying mechanisms remain poorly understood and likely include hypoxia, oxidative stress, hyperthermia, anatomical aberrations, and genetics as primary components. Despite a high prevalence amongst asymptomatic fertile men, varicoceles paradoxically also represent the most common correctable cause for male infertility...
March 2018: Arab Journal of Urology
Chak-Lam Cho, Ashok Agarwal
Objective: To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation. Methods: A search of PubMed was conducted using the keywords 'sperm DNA fragmentation' and 'male infertility'. Studies in languages other than English were excluded. All identified studies were screened and clinical studies in humans were included. Results: In all, 150 articles were included for analysis...
March 2018: Arab Journal of Urology
Meysam Jangkhah, Faramarz Farrahi, Mohammad Ali Sadighi Gilani, Seyed Jalil Hosseini, Farid Dadkhah, Reza Salmanyazdi, Mohammad Chehrazi
Background: The main purpose of this study is to evaluate the effects of varicocelectomy on serum testosterone levels and semen quality in infertile men who suffer from varicocele. MATERIALS AND METHODS: This prospective study enrolled 115 subjects with clinical varicocele grades II and III and 240 fertile men as the control group. Total volume of testosterone serum level (ng/dl) and semen quality were compared before and after microscopic varicocelectomy. We normalized testosterone serum levels for age, grade, and testis size basis...
July 2018: International Journal of Fertility & Sterility
Selahittin Çayan, Erdem Akbay
OBJECTIVE: To compare sperm parameters, serum hormone levels, and pregnancy and miscarriage rates between the infertile men with recurrent or persistent varicocele who underwent microsurgical subinguinal redo varicocelectomy or had observation only. MATERIALS AND METHODS: The study included 217 primary infertile men with recurrent or persistent varicocele. The patients were divided into 2 groups: 120 men underwent microsurgical subinguinal redo varicocelectomy, and 97 had observation only...
April 9, 2018: Urology
Javanmard Babak, Fadavi Behruz, Yousefi Mohammadreza, Fallah-Karkan Morteza
Introduction: To study the stimulating effect of human chorionic gonadotropin (hCG) on spermatogenesis in patients with varicocele and infertility undergoing varicocelectomy. Materials and Methods: In the study, 188 infertile patients with varicocele were included. Open inguinal varicocelectomy was performed. They were randomized into 2 groups and hCG (91 patients) was administered intramuscularly by dosage of 5,000 international units every week for 3 months. A semen analysis was obtained at 6 months, post-operatively and cases were followed for 2 years for pregnancy report...
February 2018: Current Urology
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