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Mansour Alizadeh, Ali Nasebakht, Rohollah Valizadeh, Mohammadreza Mohammadi Fallah, Ali Taghizadeh Afshari, Mohsen Mohammad Rahimi, Chimen Daneshyar
Introduction: Varicocele is a common problem with a high prevalence in population with primary and secondary infertilities. The adverse effects of varicocele on spermatogenesis and fertility are known, but the association between clinical varicocele and testosterone is not clear. Hence, we decided to evaluate the serum levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in patients with varicocele after varicocelectomy. Methods: In this study, 100 patients with varicocele were divided into two groups: hypogonadal patients with testosterone level <280 ng/dL and eugonadal patients with testosterone level >280 ng/dL...
2018: Therapeutics and Clinical Risk Management
Kaan Gokcen, Gokce Dundar, Halil Gulbahar, Gokhan Gokce, Emin Yener Gultekin
Background: The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer. Materials and Methods: In this cross-sectional retrospective study, we analyzed 39 patients who underwent radical orchiectomy due to a testicular cancer (Group 1) and 82 patients on whom varicocelectomy procedure was performed as control group (Group 2) between January 2006 and January 2016 in our clinic...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Thomas A Masterson, Aubrey B Greer, Ranjith Ramasamy
INTRODUCTION: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. METHODS: Men with total motile sperm count (TMSC) < 5 million on two semen analyses were identified from May 2015 to August 2017. Postoperative semen analysis was collected at 3-6 months and >6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (<5 million), intrauterine insemination (IUI) (5-9 million), and natural pregnancy (>9 million)...
August 30, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Yong-Yi Yang, Wei Huang, Jun-Jie Cao, Hong-Shen Wu, Min Cao, Yan Zhang, Xiao-Dong Jin
Objective: To compare the clinical effects and postoperative complications of microsurgical subinguinal varicocelectomy (MSV) with or without delivery of the testis and ligation of gubernacular veins in the treatment of varicocele. METHODS: We retrospectively analyzed the clinical data about 163 varicocele patients treated by MSV, 40 with (group A) and the other 123 without delivery of the testis and ligation of gubernacular veins (group B). We compared the operation time, postoperative complications, rate of recurrence, and semen parameters before and at 3 months after surgery between the two groups of patients...
March 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
Iyad Khourdaji, Haerin Lee, Ryan P Smith
For a significant number of couples worldwide, infertility is a harsh reality. As specialists in male infertility, much of our armamentarium lacks definitive, evidence-based therapies. For years, we have relied on manipulation of the male hormonal axis to treat those men who help carry the burden of infertility in their partnerships. Indeed, male factor infertility is the sole component of infertility in at least 20% of couples. Further compounding this dilemma is that 25% to 50% of males with infertility have no identifiable etiology and thus present a true management conundrum...
July 2018: Translational Andrology and Urology
Diana M Lopategui, Emad Ibrahim, Teodoro C Aballa, Nancy L Brackett, Raphael Yechieli, Julio C Barredo, Ranjith Ramasamy
Background: A formal fertility preservation program was initiated at our institution in 2016 as part of a multi-disciplinary oncofertility initiative to improve the reproductive needs of oncologic patients. After 1 year of initial experience, we assessed sperm banking rates in men diagnosed with cancer, as well as examined the trends in the use of fertility preservation services. Methods: We performed a chart review from 2011 to 2017 for men newly diagnosed with cancer, and for all men who underwent fertility preservation during that period of time at our institution...
July 2018: Translational Andrology and Urology
Chak-Lam Cho
No abstract text is available yet for this article.
August 22, 2018: Andrologia
Ali Çift, Mehmet Ozgur Yucel
In this study, was evaluated the outcomes of patients undergoing microsurgical varicocelectomy to treat scrotal pain due to recurrent varicocele were evaluated. A total of 27 patients who underwent microsurgical varicocele ligation for recurrent varicocele and scrotal and/or testicular pain were included in this retrospective study. Recurrent varicocele in all patients was diagnosed with by physical examination and coloured Doppler ultrasonography (CDUSG). All patients underwent pre-operative follow-up and post-operative follow-up at 3 and 6 months by physical examination, assessment of using the Visual Analog Scale (VAS) score, and CDUSG...
July 23, 2018: Andrologia
Nicola Zampieri, Francesco Saverio Camoglio
Preserving the fertility potential of adolescent patients with varicocele is still the main outcome of pediatric and adolescent urologysts; the aim of this study is to assess the fertility potential of patients treated for varicocele with testicular hypotrophy in absence of post-operative complications, with complete ipsilateral testicular catch-up growth and normal hormonal values. METHODS: The Authors collected data from adolescents with varicocele aged between 10 and 16 years treated at their Institution between September 2010 and September 2015...
2018: American Journal of Clinical and Experimental Urology
Yonghua Niu, Daoqi Wang, Yinwei Chen, Gaurab Pokhrel, Hao Xu, Tao Wang, Shaogang Wang, Jihong Liu
Varicocele is the most common cause of male infertility. Varicoceles are classified into two types: clinical and subclinical varicoceles. Some researchers reported right subclinical varicoceles are often accompanied with left clinical varicoceles. However, the treatment is controversial. Our aim was to compare the clinical outcome of unilateral varicocelectomy (UV) and bilateral varicocelectomy (BV) in infertile males with left clinical and right subclinical varicocele. A total of four randomised controlled trials (RCT) were enrolled in this study, including 637 cases with left clinical and right subclinical varicocele (318 cases in the BV group and 319 cases in the UV group)...
July 19, 2018: Andrologia
Omar Ayman Saadeldin, Mohamed Ahmed Abd El Salam, Omar Abdulsalam Azzazi, Abdullah Yousef Mohamed
Congenital anomalies of the male urogenital tract include a variety of structural abnormalities. These abnormalities could affect either the male external genitalia, internal genitalia or both. Congenital anomalies of the vas deferens are rare and may include unilateral or bilateral (agenesis, atresia, duplication, ectopy or diverticulum) that could be complete or segmental. In addition, they may be isolated anomalies of the vas deferens or may be associated with other congenital anomalies elsewhere especially in the male urogenital tract...
July 17, 2018: Andrologia
Sen Li, Qian Liu, Jin Wang, Xueqin Pang, Youpeng Zhang, Yongbiao Cheng, Yao Fu, Jialun Guo, Yong Tang, Hanqing Zeng, Yali Yang, Zhaohui Zhu
The recurrence rates after varicocelectomy vary from 0.9% to 32.2%, especially for patients with the left renal vein entrapment (LRVE). This study aims to study the association between LRVE and varicocele recurrence, and to find the risk factors of LRVE. With the design of a cohort study, we included 3042 varicocele patients who would undergo modified inguinal microscope-assisted varicocelectomy (MHMV). 858 (28.21%) patients with LRVE were as the study group, and 2184 (71.79%) patients without LRVE were as the control group...
July 12, 2018: Scientific Reports
Yin-Wei Chen, Yong-Hua Niu, Dao-Qi Wang, Hao Li, Gaurab Pokhrel, Hao Xu, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Varicocele is one of the common correctable causes of male infertility. Recent studies have demonstrated varicocelectomy in males with abnormal semen parameters was associated with better fertility outcome, but the effect of adjuvant drug therapy after varicocelectomy on fertility outcome in patients with varicocele-associated infertility remains undefined. Hence, the present meta-analysis was performed to assess the efficacy of adjuvant drug therapy after varicocelectomy. The protocol was registered with PROSPERO (No...
July 11, 2018: Andrologia
Phil Vu Bach, Neal Patel, Bobby B Najari, Clara Oromendia, Ryan Flannigan, Robert Brannigan, Marc Goldstein, Jim C Hu, James A Kashanian
OBJECTIVE: To assess changes in the practice patterns of urologists performing male infertility procedures (vasal reconstruction, sperm retrieval, varicocelectomy) from 2004 to 2015 in the United States. DESIGN: Examination of self-reported procedural volumes from urologists undergoing certification and recertification using case log data provided by the American Board of Urology. The study period was stratified into early (2004-2007) and recent (2012-2015) time periods...
July 1, 2018: Fertility and Sterility
Daxue Tian, Wei Huang, Huilei Yan, Huantao Zong, Yong Zhang
Varicocelectomy can improve the function of testicular Leydig cell for patients with varicocele. We carried out a systematic review and meta-analysis to assess effect of varicocelectomy on serum FSH and LH levels for patients with varicocele. A literature review was performed to identify all published randomized preoperation-postoperation clinical trials of assessing serum FSH and LH levels before and after varicocelectomy. The search included the following databases: PUBMED and EMBASE. The reference lists of retrieved studies were also investigated...
June 2018: Indian Journal of Surgery
Serajoddin Vahidi, Mohammadreza Moein, Ali Nabi, Nima Narimani
It seems that varicocele play a role in male infertility, as such, their prevalence increases from 15% in the normal population to 80% in secondary infertility subjects. Varicoceles may have negative effects on semen quality. Our goal was to assess the effects of microsurgical varicocelectomy on semen analysis and sperm functional tests in men with different grades of varicoceles. Thirty infertile men with different grades of varicoceles (grades 1 to 3) were enrolled in our study. Semen quality was assessed by semen analysis according to the WHO guideline (WHO, 1999) and four different sperm functional tests (aniline blue, toluidine blue, chromomycin A3 and TUNEL test) were carried out before and 3 months after microsurgical varicocelectomy (M-varicocelectomy)...
October 2018: Andrologia
Craig Niederberger
No abstract text is available yet for this article.
June 2018: Journal of Urology
Sunghyun Paick, Woo Suk Choi
Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain. The probable mechanisms for pain include compression of the surrounding neural fibers by the dilated venous complex, elevated testicular temperature, increased venous pressure, hypoxia, oxidative stress, hormonal imbalances, and the reflux of toxic metabolites of adrenal or renal origin. Testicular pain associated with varicoceles is typically described as a dull, aching, or throbbing pain in the testicle, scrotum, or groin; rarely, it can be acute, sharp, or stabbing...
May 16, 2018: World Journal of Men's Health
Taylor P Kohn, Samuel J Ohlander, Jake S Jacob, Tina M Griffin, Larry I Lipshultz, Alexander W Pastuszak
PURPOSE OF REVIEW: Current guidelines recommend against surgical repair of subclinical varicoceles (SCVs) for infertility; several studies demonstrate mixed fertility results after SCV correction. To determine whether surgical correction of SCV improves semen parameters and/or reproductive outcomes, we performed a systematic review and meta-analysis. Seven biomedical literature databases were searched through January 2018 for studies that assessed reproductive outcomes and/or change in semen parameters in men with corrected SCV compared to either (1) uncorrected SCV or (2) corrected clinical varicocele...
May 17, 2018: Current Urology Reports
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