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https://www.readbyqxmd.com/read/28078226/clinical-utility-of-sperm-dna-fragmentation-testing-practice-recommendations-based-on-clinical-scenarios
#1
REVIEW
Ashok Agarwal, Ahmad Majzoub, Sandro C Esteves, Edmund Ko, Ranjith Ramasamy, Armand Zini
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078218/effects-of-varicocelectomy-on-serum-testosterone
#2
REVIEW
Patrick Whelan, Laurence Levine
Varicocele is most often surgically repaired due to male infertility, however, has recently been linked to low serum testosterone. This paper serves to review the current literature regarding varicocele and its subsequent repair on serum testosterone. Twenty-eight human studies were identified with fifteen showing improved serum testosterone after repair. The majority of the studies that demonstrated improvement had preoperative testosterone levels that were low or below normal. Additionally, multiple well-designed studies with control groups not undergoing surgical repair demonstrated significant difference between groups...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28063682/recurrence-rates-in-pediatric-patients-undergoing-microsurgical-subinguinal-varicocelectomy-with-and-without-testicular-delivery
#3
Chang Il Choi, Kyung Chae Park, Tae Ho Lee, Young Kwon Hong
BACKGROUND/PURPOSE: The purpose of the study was to determine if testicular delivery during microsurgical subinguinal varicocelectomy (MSV) reduces varicocele recurrence rates in pediatric patients. Testicular delivery during MSV enables ligation of the gubernacular veins, which is thought to reduce the likelihood of varicocele recurrence. However, recent studies have suggested that testicular delivery during MSV does not offer any beneficial effect and, therefore, may be optional or unnecessary...
December 24, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28042049/a-novel-approach-of-microscopic-subinguinal-varicocelectomy-with-a-pulling-strategy
#4
Wu Kerong, Yan Guang, Yin Weiqi, Chen Xueqin, Wang Guoyao, Cheng Yue
OBJECTIVES: To investigate the safety and efficacy of a novel approach of microscopic subinguinal varicocelectomy with a "pulling" strategy. METHODS: Fifty-two male patients with varicocele were enrolled in this study. Twenty-six patients underwent conventional microscopic subinguinal varicocelectomy, whereas the remaining 26 patients accepted our novel approach of treatment. In this method, with a subinguinal incision, we dissociated the spermatic cord from the external ring...
December 29, 2016: Urology
https://www.readbyqxmd.com/read/27998669/global-vision-system-in-laparoscopy
#5
I Rivas-Blanco, E Sánchez-de-Badajoz, I García-Morales, J M Lage-Sánchez, P Sánchez-Gallegos, C J Pérez-Del-Pulgar, V F Muñoz
OBJECTIVE: The main difficulty in laparoscopic or robot-assisted surgery is the narrow visual field, restricted by the endoscope's access port. This restriction is coupled with the difficulty of handling the instruments, which is due not only to the access port but also to the loss of depth of field and perspective due to the lack of natural lighting. In this article, we describe a global vision system and report on our initial experience in a porcine model. MATERIAL AND METHODS: The global vision system consists of a series of intraabdominal devices, which increase the visual field and help recover perspective through the simulation of natural shadows...
December 17, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27867844/surgical-approaches-for-varicocele-in-pediatric-patient
#6
Alejandra Parrilli, Agnese Roberti, Maria Escolino, Ciro Esposito
BACKGROUND: Varicocele represents one of the most common surgically correctible urologic anomalies in adolescent males. The best procedure for the treatment of adolescent varicocele has not been established, but with recent advances in minimal access surgery, there have been many reports praising the safety and efficacy of laparoscopy and retroperitoneoscopy for the surgical correction of varicocele in adolescent. The aim of this review is to compare the results of Palomo's technique, with retroperitoneoscopic and transperitoneoscopic approaches in adolescent, analyzing recurrence, testicular growth and complications...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27825582/-comparison-of-subinguinal-microsurgical-varicocelectomy-vs-percutaneous-embolization-in-infertile-men
#7
M Binhazzaa, E Bounasr, G Perez, T Almont, M Soulie, M Faruch, E Huyghe
INTRODUCTION: Subinguinal microscopic ligation is the current standard of treatment of varicocele, and percutaneous embolization is a new alternative. We aimed to compare these procedures for reproductive and functional aspects. MATERIAL: A consecutive series of 76 patients with clinical varicocele, alteration of semen parameters and infertility, undergoing either procedure (microsurgery in 49 cases and embolization in 27 cases) was prospectively analyzed preoperatively and postoperatively (at 1, 3, 6, 9 and 12 months)...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27818033/does-varicocelectomy-improve-semen-analysis-outcomes-in-adolescents-without-testicular-asymmetry
#8
David I Chu, Stephen A Zderic, Aseem R Shukla, Arun K Srinivasan, Gregory E Tasian, Dana A Weiss, Christopher J Long, Douglas A Canning, Thomas F Kolon
PURPOSE: The main indications for adolescent varicocelectomy are testicular hypotrophy or pain. However, we have previously shown that both serial total testicular volume and volume differential are weakly associated with semen quality. The ultimate patient goal is paternity, but semen analysis is critical to appropriate management of varicocele. We hypothesize that varicocelectomy improves total motile count (TMC) among patients who only have abnormal semen analysis (SA) parameters, but not among those with potential hormonal dysfunction such as Klinefelter syndrome or cryptorchidism...
October 26, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27760632/-expression-and-significance-of-mir-210-in-the-epididymis-in-rats-with-varicocele-and-following-varicocelectomy
#9
Y G Chen, S F Chen, Y J Yang, A A Long, X Q Liu
Objective: To investigate the expression of microRNA 210 (miR-210) in the epididymis of rats with varicocele and changes in miR-210 expression following high spermatic vein ligation, so as to explore the significance of the surgery in treating varicocele. Methods: A total of 21 male Sprague-Dawley (SD) rats aged 7 weeks were randomly divided into control group (n=7), experimental group (n=7), and surgical group (n=7). Varicocele model was established in both the experimental and surgical groups, while only vein isolation was performed in the control group...
September 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27736254/efficacy-of-indocyanine-green-angiography-on-microsurgical-subinguinal-varicocelectomy
#10
Yasuhiro Shibata, Sota Kurihara, Seiji Arai, Haruo Kato, Tomomi Suzuki, Yoshiyuki Miyazawa, Hidekazu Koike, Kazuto Ito, Tetsuya Nakamura, Kazuhiro Suzuki
OBJECTIVES: Microsurgical subinguinal varicocelectomy is one of the best treatment modalities for varicoceles related to male infertility and scrotal pain. However, the difficulty in identifying testicular arteries, which should be spared, is a limitation of this technique. To visualize and identify the testicular arteries in spermatic cord during the operation, we examined the efficacy of intraoperative indocyanine green angiography (ICGA), which is regularly used in microsurgical neurosurgery...
October 13, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27689031/diagnosis-and-management-of-pediatric-and-adolescent-varicocele-a-survey-of-pediatric-urologists-in-korea
#11
Tae Ho Lee, Jay Ho Jung, Young Kwon Hong
The aim of this study was to evaluate current practice patterns on diagnosis and management of pediatric varicoceles. Questionnaires of approaches to diagnosis and management of pediatric varicoceles were sent electronically to pediatric urologists. Of the 70 questionnaires e-mailed, 37 (53%) responded to the survey. 10 respondents (27%) chose to operate on varicoceles, whereas 9 (24%) chose to observe, and 18 (49%) chose to decide upon treatment depending on the clinical situation. The most important indication for varicocelectomy was a decrease in ipsilateral testicular size (n=29, 78%) followed by testicular or scrotal pain (n=4, 11%) and varicocele grade (n=4, 11%)...
September 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/27688686/laparoendoscopic-single-site-surgery-varicocelectomy-versus-conventional-laparoscopic-varicocele-ligation-a-meta-analysis
#12
Mingchao Li, Zhengyun Wang, Hao Li
OBJECTIVE: To perform a meta-analysis of data from available published studies comparing laparoendoscopic single-site surgery varicocelectomy (LESSV) with conventional transperitoneal laparoscopic varicocele ligation. METHODS: A comprehensive data search was performed in PubMed and Embase to identify randomized controlled trials and comparative studies that compared the two surgical approaches for the treatment of varicoceles. RESULTS: Six studies were included in the meta-analysis...
September 29, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27678469/the-application-of-laparoscopic-doppler-ultrasound-during-laparoscopic-varicocelectomy-in-infertile-men
#13
Li-Qiang Guo, Xiu-Lin Zhang, Yu-Qiang Liu, Wen-Dong Sun, Sheng-Tian Zhao, Ming-Zhen Yuan
The aim of this study is to evaluate the benefits of laparoscopic Doppler ultrasound (LDU) application during laparoscopic varicocelectomy (LV), and to compare the surgical outcomes and complications between LDU-assisted LV (LDU-LV) and conventional LV for infertile patients with varicoceles; 147 infertile patients were randomly divided into two groups. Operative and postoperative parameters, semen parameters, and the pregnancy rate were compared. There were no differences in baseline demographics. The operative time was significantly longer in LDU-LV group than LV group...
September 27, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27652057/laparoendoscopic-single-site-varicocelectomy-compared-with-conventional-laparoscopic-surgery-a-systematic-review-and-meta-analysis
#14
REVIEW
Tao Wu, Xi Duan, Xuesong Yang, Xianzhong Deng, Shu Cui
PURPOSE: To present a systematic review and meta-analysis comparing laparoendoscopics single-site varicocelectomy (LESS-V) versus conventional laparoscopic surgery (CTL-V). METHODS: A literature search was performed using The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded and Google Scholar. Literature reviewed included meta-analyses, and randomized and nonrandomized prospective studies. We utilized weight mean difference (WMD) to measure hospital stay, time to return normal activity, postoperative pain and improvement of semen parameters and odds ratio (OR) to postoperative complications and cosmetic satisfaction...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27576887/six-years-experience-of-laparoscopic-varicocelectomy-using-bipolar-electrosurgery-and-its-effect-on-semen-parameters
#15
Hossein Karami, Amin Hassanzade Hadad, Morteza Fallahkarkan
PURPOSE: To evaluate postoperative results of laparoscopic varicocelectomy using bipolar electrosurgery and analyze semen according to the grade of varicocele after surgery. MATERIALS AND METHODS: In a six-year period, 416 men with clinical varicocele and impaired semen parameters or infertility underwent laparoscopic varicocelectomy using bipolar electrosurgery. All patients were assessed for hydrocele and recurrence of varicocele six months and one year after the procedure...
August 25, 2016: Urology Journal
https://www.readbyqxmd.com/read/27574593/clinical-outcomes-of-varicocele-repair-in-infertile-men-a-review
#16
REVIEW
Koji Chiba, Masato Fujisawa
Varicoceles are a major cause of impaired spermatogenesis and the most common correctable cause of male infertility. They are found in approximately 40% of men with primary infertility and 80% of men with secondary infertility, although they also occur in 12% of men with normal semen parameters. The presence of a varicocele does not always affect spermatogenesis, as it has been reported that only 20% of men with documented varicoceles suffer fertility problems. However, varicocele repair appears to have beneficial effects in men with impaired semen parameters and palpable varicoceles...
August 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/27565125/beneficial-effects-of-microsurgical-varicocoelectomy-on-sperm-maturation-dna-fragmentation-and-nuclear-sulfhydryl-groups-a%C3%A2-prospective-trial
#17
N Alhathal, M San Gabriel, A Zini
There is evidence to show that varicocele repair can improve conventional sperm parameters but the effects on sperm chromatin integrity have not been fully elucidated. We sought to examine the effects of varicocelectomy on sperm maturation, nuclear chromatin integrity and nuclear sulfhydryl groups. We conducted a prospective study of consecutive infertile men (n=29) that underwent a microsurgical sub-inguinal varicocelectomy for treatment of a clinically palpable varicocele and abnormal semen parameters. Six healthy sperm donors served as controls...
August 27, 2016: Andrology
https://www.readbyqxmd.com/read/27545577/predictive-factors-for-sperm-recovery-after-varicocelectomy-in-men-with-nonobstructive-azoospermia
#18
Koji Shiraishi, Shintaro Oka, Hideyasu Matsuyama
PURPOSE: The ability of testicular histopathology to predict the success of microsurgical varicocelectomy in patients with nonobstructive azoospermia was investigated. We used a next generation sequencer to compare the transcriptomes of varicocelectomy responsive and nonresponsive testes to identify the factors that predict sperm in the ejaculate. MATERIALS AND METHODS: A total of 83 men with nonobstructive azoospermia and left varicocele underwent microsurgical varicocelectomy with simultaneous testicular biopsy...
August 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27441150/anatomical-factors-affecting-the-time-required-for-microsurgical-subinguinal-varicocelectomy
#19
Jung Keun Lee, Ho Young Ryu, Jae-Seung Paick, Soo Woong Kim
BACKGROUND: Microsurgical subinguinal varicocelectomy (MSV) is considered an effective and less morbid procedure, but the difficulty in preserving testicular arteries is a limitation of this procedure. We identified the microanatomy encountered during MSV and clarify its significance to the difficulty of the procedure. METHODS: Three hundred and twenty-six patients who underwent left MSV were evaluated. Detailed intraoperative microanatomy was recorded for each case...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27424121/venous-blood-gases-of-varicocele-veins-correlation-with-testicular-blood-flow-and-semen-quality-in-varicocele-patients
#20
Khaleeq Ur Rehman, Hafsa Zaneb, Ahsan Numan, Abdul Basit Qureshi, Imtiaz Rabbani, Mohamad Shehbaz Yousaf, Habib Ur Rehman
OBJECTIVE: To investigate venous blood gases (VBG) in varicocele veins and correlation with semen and testicular blood flow. MATERIAL AND METHODS: Twenty-seven infertile patients, undergoing left microsurgical varicocelectomy, at Urology/Andrology Department of a teaching hospital, were included. Before surgery semen parameters were recorded and scrotal color doppler ultrasonography (CDUS) done to measure peak systolic velocity (PSV) resistive index (RI) of sub capsular and intra parenchymal branches of testicular artery...
July 13, 2016: Urology
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