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Erhan Ates, Murat Ucar, Mehmet Zeynel Keskin, Ahmet Gokce
Various studies have been reported to predict the success of varicocelectomy. Neutrophil-lymphocyte ratio (NLR) is a frequently used indicator of systemic inflammation. We aimed to evaluate the effect of inflammation on the success of varicocelectomy using the NLR. The data of 86 patients who underwent varicocelectomy for infertility were evaluated retrospectively. Pre-operative demographic characteristics of patients, laboratory results such as haemogram, and semen analysis and clinical data were recorded...
November 5, 2018: Andrologia
Cailey Guercio, Dattatraya Patil, Akanksha Mehta
We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA. We queried the 2009-2015 MarketScan Database using relevant ICD9, ICD10, and CPT codes to identify all 18-45 year olds with varicoceles. Differences in age, area of residence, clinical characteristics, and medical management between men who did and did not undergo varicocelectomy (open, laparoscopic, or microsurgical) during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables, respectively...
October 26, 2018: Asian Journal of Andrology
Abdelshakour A Al-Mohammady, Ahmed F El-Sherbiny, Amira B Mehaney, Yasser A Ghobara
PURPOSE: This study sought to evaluate the impact of varicocele repair on intracytoplasmic sperm injection outcomes. PATIENTS AND METHODS: A prospective comparative study was conducted at the Assisted Reproduction Unit, International Islamic Center for Population Studies and Researches, Al-Azhar University. This study included 100 non-azoospermic infertile men with a history of varicocele who were scheduled for intracytoplasmic sperm injection, half of them had already undergone prior subinguinal varicocelectomy at least 12 months prior to ICSI without clinically evident recurrence (treated group 1), and the other half has any grade of an unrepaired clinical varicocele (untreated group 2) at sperm injection...
October 29, 2018: Andrologia
Seung Ryong Baek, Hyun Jun Park, Nam Cheol Park
We investigated the clinical characteristics of patients with varicocele according to the presence or absence of scrotal pain. We retrospectively reviewed the records of patients who underwent varicocelectomy. The age, body mass index, grade, laterality of varicocele, testicular volume difference, time to hospital visit, serum testosterone level and semen parameters were evaluated. A total of 954 patients were included. The painful group had lower mean age, lower BMI, higher grade of varicocele, smaller testicular volume difference and shorter time to hospital visit than the painless group...
October 25, 2018: Andrologia
L Belardin, M Camargo, P Intasqui, M Antoniassi, R Fraietta, R Bertolla
BACKGROUND: Cysteine-rich secretory protein (CRISP-3), a protein involved in inflammatory response, is highly increased in seminal plasma of adolescents with varicocoele and altered semen analysis, but not in adolescents with varicocoele and normal semen. It is not known, however, whether this increased seminal concentration occurs as an acute marker during the initial stages of varicocoele or whether this persists as an altered protein pathway. OBJECTIVE: The purpose of this study, thus, was to test the hypothesis that this inflammatory state persists through adulthood and the correction of varicocoele could correct this state, by identifying the levels of CRISP-3 in seminal plasma...
October 24, 2018: Andrology
Helen Levey Bernie, Marc Goldstein
As men age, serum testosterone levels decrease. This reduction in testosterone levels may cause symptoms leading to hypogonadism. In addition, the presence of a varicocele can impair Leydig cell function, resulting in decreased testosterone production in men. Varicocelectomy and testosterone replacement therapy are both viable treatment options for hypogonadism in elderly male patients. The correct modality of treatment will vary for each patient, but education is essential in order to help men understand their options...
April 2018: European Urology Focus
Hesamoddin Sajadi, Jalil Hosseini, Faramarz Farrahi, Farid Dadkhah, Mahdi Sepidarkish, Marjan Sabbaghian, Poopak Eftekhari-Yazdi, Mohammad Ali Sadighi Gilani
Background: Assessing the net-results of microsurgical varicocelectomy in infertile men with non-obstructive azoospermic (NOA) and clinical varicocele in five years at Royan Institute. Materials and Methods: This is a descriptive retrospective cohort study. A backward-looking review of patients treated for NOA and varicocele from march 2011 to march 2016 was performed. In addition, MDTESE results of 57 patients with NOA and clinical varicocele, with 537 NOA patients without varicocele were compared...
January 2019: International Journal of Fertility & Sterility
M Zavattaro, C Ceruti, G Motta, S Allasia, L Marinelli, C Di Bisceglie, M P Tagliabue, M Sibona, L Rolle, F Lanfranco
PURPOSE: Varicocele is defined as a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow through the internal spermatic vein. The prevalence of clinically relevant varicocele ranges from 5 to 20% in the male population and is often associated with infertility and reduction of sperm quality. In this review, the pathophysiology and clinical aspects of varicocele are reviewed along with therapeutic options and treatment effects on sperm parameters and fertility both in adult and in pediatric/adolescent subjects...
October 3, 2018: Journal of Endocrinological Investigation
Kostas Chondros, Evangelos Kountourakis, Marina Kalogridaki, Konstantinos Grekos
Varicocele represents a common problem in young men with infertility or chronic scrotal pain and it is located on the left side in the vast majority of the cases. Right isolated varicocele is a quite rare entity, especially in middle-aged men and as the single pathology responsible for chronic pain. Further investigation might be needed to exclude other retroperitoneal or scrotal hidden lesions. Several surgical options are available for symptomatic patients with clinical varicocele including the laparoscopic approach of high ligation of the spermatic veins...
2018: AME case reports
Mansour Alizadeh, Ali Nasebakht, Rohollah Valizadeh, Mohammadreza Mohammadi Fallah, Ali Taghizadeh Afshari, Mohsen Mohammad Rahimi, Chimen Daneshyar
Introduction: Varicocele is a common problem with a high prevalence in population with primary and secondary infertilities. The adverse effects of varicocele on spermatogenesis and fertility are known, but the association between clinical varicocele and testosterone is not clear. Hence, we decided to evaluate the serum levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in patients with varicocele after varicocelectomy. Methods: In this study, 100 patients with varicocele were divided into two groups: hypogonadal patients with testosterone level <280 ng/dL and eugonadal patients with testosterone level >280 ng/dL...
2018: Therapeutics and Clinical Risk Management
Kaan Gokcen, Gokce Dundar, Halil Gulbahar, Gokhan Gokce, Emin Yener Gultekin
Background: The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer. Materials and Methods: In this cross-sectional retrospective study, we analyzed 39 patients who underwent radical orchiectomy due to a testicular cancer (Group 1) and 82 patients on whom varicocelectomy procedure was performed as control group (Group 2) between January 2006 and January 2016 in our clinic...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Thomas A Masterson, Aubrey B Greer, Ranjith Ramasamy
INTRODUCTION: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. METHODS: Men with total motile sperm count (TMSC) < 5 million on two semen analyses were identified from May 2015 to August 2017. Postoperative semen analysis was collected at 3-6 months and >6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (<5 million), intrauterine insemination (IUI) (5-9 million), and natural pregnancy (>9 million)...
August 30, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Yong-Yi Yang, Wei Huang, Jun-Jie Cao, Hong-Shen Wu, Min Cao, Yan Zhang, Xiao-Dong Jin
Objective: To compare the clinical effects and postoperative complications of microsurgical subinguinal varicocelectomy (MSV) with or without delivery of the testis and ligation of gubernacular veins in the treatment of varicocele. METHODS: We retrospectively analyzed the clinical data about 163 varicocele patients treated by MSV, 40 with (group A) and the other 123 without delivery of the testis and ligation of gubernacular veins (group B). We compared the operation time, postoperative complications, rate of recurrence, and semen parameters before and at 3 months after surgery between the two groups of patients...
March 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
Iyad Khourdaji, Haerin Lee, Ryan P Smith
For a significant number of couples worldwide, infertility is a harsh reality. As specialists in male infertility, much of our armamentarium lacks definitive, evidence-based therapies. For years, we have relied on manipulation of the male hormonal axis to treat those men who help carry the burden of infertility in their partnerships. Indeed, male factor infertility is the sole component of infertility in at least 20% of couples. Further compounding this dilemma is that 25% to 50% of males with infertility have no identifiable etiology and thus present a true management conundrum...
July 2018: Translational Andrology and Urology
Diana M Lopategui, Emad Ibrahim, Teodoro C Aballa, Nancy L Brackett, Raphael Yechieli, Julio C Barredo, Ranjith Ramasamy
Background: A formal fertility preservation program was initiated at our institution in 2016 as part of a multi-disciplinary oncofertility initiative to improve the reproductive needs of oncologic patients. After 1 year of initial experience, we assessed sperm banking rates in men diagnosed with cancer, as well as examined the trends in the use of fertility preservation services. Methods: We performed a chart review from 2011 to 2017 for men newly diagnosed with cancer, and for all men who underwent fertility preservation during that period of time at our institution...
July 2018: Translational Andrology and Urology
Chak-Lam Cho
No abstract text is available yet for this article.
August 22, 2018: Andrologia
Ali Çift, Mehmet Ozgur Yucel
In this study, was evaluated the outcomes of patients undergoing microsurgical varicocelectomy to treat scrotal pain due to recurrent varicocele were evaluated. A total of 27 patients who underwent microsurgical varicocele ligation for recurrent varicocele and scrotal and/or testicular pain were included in this retrospective study. Recurrent varicocele in all patients was diagnosed with by physical examination and coloured Doppler ultrasonography (CDUSG). All patients underwent pre-operative follow-up and post-operative follow-up at 3 and 6 months by physical examination, assessment of using the Visual Analog Scale (VAS) score, and CDUSG...
July 23, 2018: Andrologia
Nicola Zampieri, Francesco Saverio Camoglio
Preserving the fertility potential of adolescent patients with varicocele is still the main outcome of pediatric and adolescent urologysts; the aim of this study is to assess the fertility potential of patients treated for varicocele with testicular hypotrophy in absence of post-operative complications, with complete ipsilateral testicular catch-up growth and normal hormonal values. METHODS: The Authors collected data from adolescents with varicocele aged between 10 and 16 years treated at their Institution between September 2010 and September 2015...
2018: American Journal of Clinical and Experimental Urology
Yonghua Niu, Daoqi Wang, Yinwei Chen, Gaurab Pokhrel, Hao Xu, Tao Wang, Shaogang Wang, Jihong Liu
Varicocele is the most common cause of male infertility. Varicoceles are classified into two types: clinical and subclinical varicoceles. Some researchers reported right subclinical varicoceles are often accompanied with left clinical varicoceles. However, the treatment is controversial. Our aim was to compare the clinical outcome of unilateral varicocelectomy (UV) and bilateral varicocelectomy (BV) in infertile males with left clinical and right subclinical varicocele. A total of four randomised controlled trials (RCT) were enrolled in this study, including 637 cases with left clinical and right subclinical varicocele (318 cases in the BV group and 319 cases in the UV group)...
July 19, 2018: Andrologia
Omar Ayman Saadeldin, Mohamed Ahmed Abd El Salam, Omar Abdulsalam Azzazi, Abdullah Yousef Mohamed
Congenital anomalies of the male urogenital tract include a variety of structural abnormalities. These abnormalities could affect either the male external genitalia, internal genitalia or both. Congenital anomalies of the vas deferens are rare and may include unilateral or bilateral (agenesis, atresia, duplication, ectopy or diverticulum) that could be complete or segmental. In addition, they may be isolated anomalies of the vas deferens or may be associated with other congenital anomalies elsewhere especially in the male urogenital tract...
July 17, 2018: Andrologia
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