Sinmanus Vimonpatranon, Livia R Goes, Amanda Chan, Isabella Licavoli, Jordan McMurry, Samuel R Wertz, Anush Arakelyan, Dawei Huang, Andrew Jiang, Cindy Huang, Joyce Zhou, Jason Yolitz, Alexandre Girard, Donald Van Ryk, Danlan Wei, Il Young Hwang, Craig Martens, Kishore Kanakabandi, Kimmo Virtaneva, Stacy Ricklefs, Benjamin P Darwitz, Marcelo A Soares, Kovit Pattanapanyasat, Anthony S Fauci, James Arthos, Claudia Cicala
CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent HIV reservoirs that are established during the very early stages of infection. The tissue-specific factors that direct T cells to establish tissue residency are not well defined, nor are the factors that establish viral latency. We report that costimulation via MAdCAM-1 and retinoic acid (RA), two constituents of gut tissues, together with TGF-β, promote the differentiation of CD4+ T cells into a distinct subset α4β7+CD69+CD103+ TRM -like cells...
March 10, 2023: PLoS Pathogens