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https://www.readbyqxmd.com/read/29163684/novel-peptide-screened-from-a-phage-display-library-antagonizes-the-activity-of-cc-chemokine-receptor-9
#1
Yi Hu, Aiping Ma, Shan Lin, Yang Yang, Guolin Hong
CC chemokine receptor 9 (CCR9) serves a role in the drug resistance and metastasis of tumors. In the present study, a peptide specifically bound to CCR9 was obtained and the effect on tumor cells was observed. A Ph.D.-12 phage display peptide library was used to screen for peptides binding specifically to the second extracellular loop of CCR9. The ratios of the input and output of phage clones increased gradually following three rounds of biopanning. A total of 8 positive phage clones were identified from DNA analysis...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29154408/chemokine-c-c-motif-ligand-25-expressed-by-trophoblast-cells-and-leukocytes-bearing-its-receptor-ccr9-an-alliance-during-embryo-implantation
#2
Rodrigo Barbano Weingrill, Mara S Hoshida, Ciro Dresch Martinhago, Simone Correa-Silva, Elaine Cardoso, Patrícia Palmeira, Claudio Romero Farias Marinho, Estela Bevilacqua
PROBLEM: We hypothesized that trophoblast expression of Ccl25 attracts a specific leukocyte cell population to the implantation site for local regulation. METHOD OF STUDY: Mice blastocysts, ectoplacental cones, and decidua at gestational days 3.5-7.5 were evaluated for Ccl25 and Ccr9 expressions. Peripheral availability and characterization of Ccr9+ leukocytes were determined by flow cytometry. Leukocyte chemotaxis was assessed in the presence of Ccl25 recombinant protein and embryos using antisense oligomers (ODNs) to Ccl25 and Ccr9 neutralizing antibody...
November 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29106985/the-chemokine-receptor-ccr2-maintains-plasmacytoid-dendritic-cell-homeostasis
#3
Oriane Cédile, Line Østerby Jørgensen, Ida Frank, Agnieszka Wlodarczyk, Trevor Owens
Thymic dendritic cells (DC) play a role in central tolerance. Three thymic DC subtypes have been described: plasmacytoid DC (pDC) and two conventional DC (cDC), CD8α(+) Sirpα(-) DC and Sirpα(+) CD8α(-) cDC. Both pDC and Sirpα(+) cDC can take up antigen in periphery and migrate into the thymus in response to chemokine signaling via CCR9 and CCR2 respectively. CCL2 is a major ligand for CCR2 and we previously showed that it was constitutively expressed in thymus, and that mice overexpressing CCL2 in thymus had reduced numbers of autoreactive T cells but elevated numbers of pDC...
October 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29097494/gut-microbiome-influences-efficacy-of-pd-1-based-immunotherapy-against-epithelial-tumors
#4
Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Remon Masip, Charles Naltet, Solenn Brosseau, Coureche Kaderbhai, Corentin Richard, Hira Rizvi, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Bernhard Ryffel, Véronique Minard-Colin, Patrick Gonin, Jean-Charles Soria, Eric Deutsch, Yohann Loriot, François Ghiringhelli, Gérard Zalcman, François Goldwasser, Bernard Escudier, Matthew D Hellmann, Alexander Eggermont, Didier Raoult, Laurence Albiges, Guido Kroemer, Laurence Zitvogel
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizeable minority of cancer patients. Here, we show that primary resistance to ICI can be due to abnormal gut microbiome composition. Antibiotics (ATB) inhibited the clinical benefit of ICI in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICI (but not from non-responding patients) into germ-free or ATB-treated mice ameliorated the antitumor effects of PD-1 blockade...
November 2, 2017: Science
https://www.readbyqxmd.com/read/29077981/tissue-specific-differences-in-immune-cell-subsets-located-in-the-naso-oropharyngeal-associated-lymphoid-tissues
#5
Maria Bankvall, Mats Jontell, Agnes Wold, Sofia Östman
Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient oral and nasal delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T-cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN, and PLN...
October 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29073082/transcription-factor-isx-mediates-the-cross-talk-between-diet-and-immunity
#6
Made Airanthi K Widjaja-Adhi, Grzegorz Palczewski, Kali Dale, Elizabeth A Knauss, Mary E Kelly, Marcin Golczak, Alan D Levine, Johannes von Lintig
The intestinal epithelium is a major site for the conversion of dietary β-carotene to retinaldehyde by the enzyme BCO1. The majority of retinaldehyde is further metabolized to retinol (vitamin A), esterified and packaged into triacylglycerol-rich chylomicrons for bodily distribution. Some serve on-site for the synthesis of retinoic acid, a hormone-like compound, which exerts pleiotropic and dominant effects on gastrointestinal immunity. We report here that the intestine-specific homeobox protein ISX is critical to control the metabolic flow of β-carotene through this important branching point of vitamin A metabolism...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29020986/colorectal-cancer-infiltrating-t-lymphocytes-display-a-distinct-chemokine-receptor-expression-profile
#7
Ann-Britt Löfroos, Mohammad Kadivar, Sabina Resic Lindehammer, Jan Marsal
BACKGROUND: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recruitment of T lymphocytes is largely dependent on their expression of various chemokine receptors...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28986277/upregulation-of-peripheral-cxc-and-cc-chemokine-receptor-expression-on-cd4-t-cells-is-associated-with-immune-dysregulation-in-children-with-autism
#8
Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet, Laila Yousef Al-Ayadhi, Sabry M Attia
Autism spectrum disorders (ASD) are characterized by disturbances in social interactions and communication, restricted repetitive interests, and stereotyped behavior. Cumulative evidence recommends that there are immune alterations in ASD. Chemokine receptors are known to play an important role in the central nervous system (CNS) and in many neuro inflammatory disorders. The main objective of this study was to explore the role of CXC and CC chemokine receptors signaling in children with autism. We examined chemokine receptor production of CXCR2, CXCR3, CXCR5, and CXCR7 in all peripheral blood mononuclear cells (PBMCs) and in CD4(+) T cells of typically developing control children (TD) and autistic children (AU)...
October 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28961803/anti-madcam-antibody-increases-%C3%AE-7-t-cells-and-ccr9-gene-expression-in-the-peripheral-blood-of-patients-with-crohn-s-disease
#9
Mina Hassan-Zahraee, Anindita Banerjee, John B Cheng, Weidong Zhang, Alaa Ahmad, Karen Page, David von Schack, Baohong Zhang, Steven W Martin, Satyaprakash Nayak, Padma Reddy, Li Xi, Hendrik Neubert, Mireia Fernandez Ocana, Ken Gorelick, Robert Clare, Michael Vincent, Fabio Cataldi, Kenneth Hung
Objective: To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn's disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody. Methods: In this Phase 2, randomized, double-blind, controlled study [OPERA], blood samples were analysed from patients with moderate to severe active CD who received placebo or 22.5 mg, 75 mg, or 225 mg of PF-00547659 subcutaneously at baseline and at Weeks 4 and 8, with follow-up at Week 12...
September 7, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28951425/differential-t-cell-homing-to-colon-vs-small-intestine-is-imprinted-by-local-cd11c-apcs-that-determine-homing-receptors
#10
Amiran Dzutsev, Alison Hogg, Yongjun Sui, Shahram Solaymani-Mohammadi, Huifeng Yu, Blake Frey, Yichuan Wang, Jay A Berzofsky
Mechanisms that imprint T cell homing to the small intestine have been well studied; however, those for homing to the colon are poorly understood. Recently, we found that these are distinct subcompartments of the gut mucosal immune system, which implies differential homing. Here, we show that colonic CD11c(+) APCs imprint CD8(+) T cell preferential homing to the colon, in contrast to those from the small intestine that imprint CD8(+) T cell homing to the small intestine, and that the differences are related to the variable ability of APCs to induce α4β7-integrin and CCR9 expression on T cells...
September 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28903065/inflammation-polymorphisms-and-prostate-cancer-risk-in-jamaican-men-role-of-obesity-body-size
#11
Bhawna Dubey, Maria D Jackson, Charnita Zeigler-Johnson, Karthik Devarajan, Rafael E Flores-Obando, Norma McFarlane-Anderson, Marshall K Tulloch-Reid, William Aiken, Kevin Kimbro, Dominique Z Jones, LaCreis R Kidd, Camille Ragin
African ancestry and obesity are associated with higher risk of prostate cancer (PC). In a pilot study, we explored interactions between obesity (as measured by waist to hip ratio (WHR)) and inflammatory SNPs in relation to PC risk among Jamaican men. This study evaluated 87 chemokine and cytokine associated SNPs in obese and normal weight cases (N=109) and controls (N=102) using a stepwise penalized logistic regression approach in multivariable analyses. Upon stratification by WHR (normal weight (WHR<0...
December 15, 2017: Gene
https://www.readbyqxmd.com/read/28833046/ahr-activation-increases-il-2-production-by-alloreactive-cd4-t-cells-initiating-the-differentiation-of-mucosal-homing-tim3-lag3-tr1-cells
#12
Allison K Ehrlich, Jamie M Pennington, Susan Tilton, Xisheng Wang, Nikki B Marshall, Diana Rohlman, Castle Funatake, Sumit Punj, Edmond O'Donnell, Zhen Yu, Siva K Kolluri, Nancy I Kerkvliet
Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR-induced Foxp3(+) Treg cells have been well studied, much less is known about the development and fate of AhR-induced Type 1 Treg (AhR-Tr1) cells. In the current study, we identified the unique transcriptional and functional changes in murine CD4(+) T cells that accompany the differentiation of AhR-Tr1 cells during the CD4(+) T-cell-dependent phase of an allospecific cytotoxic T lymphocyte (allo-CTL) response...
November 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28808299/gut-homing-%C3%AE-42pd1-v%C3%AE-2-t-cells-promote-innate-mucosal-damage-via-tlr4-during-acute-hiv-type-1-infection
#13
Allen Ka Loon Cheung, Hau-Yee Kwok, Yiru Huang, Min Chen, Yufei Mo, Xilin Wu, Ka-Shing Lam, Hoi-Kuan Kong, Terrence Chi Kong Lau, Jingying Zhou, Jingjing Li, Lin Cheng, Boon Kiat Lee, Qiaoli Peng, Xiaofan Lu, Minghui An, Hui Wang, Hong Shang, Boping Zhou, Hao Wu, Aimin Xu, Kwok-Yung Yuen, Zhiwei Chen
The innate immune cells underlying mucosal inflammatory responses and damage during acute HIV-1 infection remain incompletely understood. Here, we report a Vδ2 subset of gut-homing γδ T cells with significantly upregulated Δ42PD1 (a PD1 isoform) in acute (~20%) HIV-1 patients compared to chronic HIV-1 patients (~11%) and healthy controls (~2%). The frequency of Δ42PD1(+)Vδ2 cells correlates positively with plasma levels of pro-inflammatory cytokines and fatty-acid-binding protein before detectable lipopolysaccharide in acute patients...
October 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28624470/molecular-cloning-and-expression-analysis-of-ccl25-and-its-receptor-ccr9s-from-epinephelus-coioides-post-cryptocaryon-irritans-infection
#14
Man Yang, Ling Zhou, Hai-Qing Wang, Xiao-Chun Luo, Xue-Ming Dan, Yan-Wei Li
Among other functions, CCL25/CCR9 has an important role in regulating the trafficking of developing T cells in the thymus, and in homing memory T cells to the small intestine. The function of this chemokine-receptor complex is not well studied in fish. We identified a CCL25-like (EcCCL25, 108 aa) and two CCR9-like sequences (EcCCR9aa 373 aa; and EcCCR9b, 375 aa) from a transcriptome database of orange-spotted grouper (Epinephelus coioides). EcCCL25, EcCCR9a, and EcCCR9b shared conserved structural features with homologs from mammals and from other fish, and a consistent relationship with phylogenetic trees and sequence identities...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28622456/increased-ccl25-and-t-helper-cells-expressing-ccr9-in-the-salivary-glands-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-potential-new-axis-in-lymphoid-neogenesis
#15
Sofie L M Blokland, Maarten R Hillen, Aike A Kruize, Stephan Meller, Bernhard Homey, Glennda M Smithson, Timothy R D J Radstake, Joel A G van Roon
OBJECTIVE: Follicular helper T (Tfh) cells play a critical role in germinal center formation and B cell activation, both of which are hallmarks of primary Sjögren's syndrome (SS). CCR9-expressing T helper cells have "Tfh-like" characteristics and their numbers are increased at mucosa-associated sites in several inflammatory conditions. Because the characteristics of these cells are unique and evaluation has been limited, this study was undertaken to investigate the local and systemic CCL25/CCR9 axis in patients with primary SS...
October 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28579989/acute-simian-immunodeficiency-virus-infection-triggers-early-and-transient-interleukin-7-production-in-the-gut-leading-to-enhanced-local-chemokine-expression-and-intestinal-immune-cell-homing
#16
Rosalie Ponte, Magali Rancez, Suzanne Figueiredo-Morgado, Jacques Dutrieux, Véronique Fabre-Mersseman, Bénédicte Charmeteau-de-Muylder, Thomas Guilbert, Jean-Pierre Routy, Rémi Cheynier, Anne Couëdel-Courteille
The intestinal barrier, one of the first targets of HIV/simian immunodeficiency virus (SIV) is subjected to major physiological changes during acute infection. Having previously shown that pharmaceutical injection of interleukin-7 (IL-7) triggers chemokine expression in many organs leading to massive T-cell homing, in particular to the intestine, we here explored mucosal IL-7 expression as part of the cytokine storm occurring during the acute phase of SIV infection in rhesus macaques. Quantifying both mRNA and protein in tissues, we demonstrated a transient increase of IL-7 expression in the small intestine of SIV-infected rhesus macaques, starting with local detection of the virus by day 3 of infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28453759/randomised-double-blind-placebo-controlled-trial-of-ccr9-targeted-leukapheresis-treatment-of-ulcerative-colitis-patients
#17
Michael Eberhardson, Per Karlén, Ludvig Linton, Petra Jones, Annelie Lindberg, Martina Jones Kostalla, Emma Lindh, Anders Odén, Hans Glise, Ola Winqvist
Background and Aims: Ulcerative colitis patients display increased numbers of circulating pro-inflammatory monocyte human leukocyte antigen-DR [HLA-DRhi] monocytes expressing high levels of the gut-homing C-C chemokine receptor 9 [CCR9] and tumour necrosis factor [TNF]-α. The aim of this first-in-human, double-blind, randomised, placebo-controlled trial was to evaluate selective removal of circulating CCR9-expressing monocytes by leukapheresis in patients with moderate to severe ulcerative colitis, with regards to safety, tolerability, and immunological response...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28428786/challenge-of-humans-with-wild-type-salmonella-enterica-serovar-typhi-elicits-changes-in-the-activation-and-homing-characteristics-of-mucosal-associated-invariant-t-cells
#18
Rosângela Salerno-Goncalves, David Luo, Stephanie Fresnay, Laurence Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Gastrointestinal infections by Salmonella enterica serovar Typhi (S. Typhi) are rare in industrialized countries. However, they remain a major public health problem in the developing world with an estimated 26.9 million new cases annually and significant mortality when untreated. Recently, we provided the first direct evidence that CD8(+) MAIT cells are activated and have the potential to kill cells exposed to S. Typhi, and that these responses are dependent on bacterial load. However, MAIT cell kinetics and function during bacterial infections in humans remain largely unknown...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28387445/stimulation-of-oral-fibroblast-chemokine-receptors-identifies-ccr3-and-ccr4-as-potential-wound-healing-targets
#19
Jeroen K Buskermolen, Sanne Roffel, Susan Gibbs
The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation, migration, and/or the release of wound healing mediators. This information may provide insight into the superior wound healing characteristics of the oral mucosa. The gingiva fibroblasts expressed 12 different chemokine receptors (CCR3, CCR4, CCR6, CCR9, CCR10, CXCR1, CXCR2, CXCR4, CXCR5, CXCR7, CX3CR1, and XCR1), as analyzed by flow cytometry. Fourteen corresponding chemokines (CCL5, CCL15, CCL20, CCL22, CCL25, CCL27, CCL28, CXCL1, CXCL8, CXCL11, CXCL12, CXCL13, CX3CL1, and XCL1) were used to study the activation of these receptors on gingiva fibroblasts...
November 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28380463/wnt5a-and-ccl25-promote-adult-t-cell-acute-lymphoblastic-leukemia-cell-migration-invasion-and-metastasis
#20
Xinzhou Deng, Zhenbo Tu, Meng Xiong, Kingsley Tembo, Lu Zhou, Pan Liu, Shan Pan, Jie Xiong, Xiangyong Yang, Jun Leng, Qian Zhang, Ruijing Xiao, Qiuping Zhang
Adult T-cell acute lymphoblastic leukemia (T-ALL) is a refractory leukemia. We previously showed that CCL25/CCR9 promotes T-ALL metastasis. In the present study, we assessed the effects of CCL25 on Wnt expression and the effects of Wnt5a and CCL25 on PI3K/Akt and RhoA activation. Transwell assays and mouse xenograft experiments were utilized to assess the effects of Wnt5a and CCL25 on MOLT4 cell invasion, migration and metastasis. The effects of Wnt5a on MOLT4 cell actin polarization and pseudopodium formation were examined using laser scanning confocal microscopy and scanning electron microscopy...
June 13, 2017: Oncotarget
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