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TIMP-2

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https://www.readbyqxmd.com/read/28238240/altered-plasma-microrna-expression-in-patients-with-mitral-chordae-tendineae-rupture
#1
Mehmet Bulent Vatan, Aysel Kalaycı Yigin, Ramazan Akdemir, Mustafa Tarik Agac, Mehmet Akif Cakar, Murat Aksoy, Ersan Tatli, Harun Kilic, Huseyin Gunduz, Derya Guzel, Keziban Karacan
BACKGROUND: Mitral chordae tendineae rupture (MCTR) is a progressive disorder which leads to severe mitral regurgitation. Despite its importance, the precise pathogenetic mechanism of MCTR remains unclear. The study aim was to investigate the expression profile of circulating microRNAs (miRNAs) as being potentially involved in the development of MCTR. METHODS: Twenty-one patients with 'primary' MCTR, and 30 age- and gender-matched controls, were enrolled in the study...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28229451/honokiol-protects-skin-cells-against-inflammation-collagenolysis-apoptosis-and-senescence-caused-by-cigarette-smoke-damage
#2
Adilson Costa, Gustavo Facchini, Ana Lúcia T A Pinheiro, Michelle S da Silva, Michael Y Bonner, Jack Arbiser, Samara Eberlin
BACKGROUND: Pollution, especially cigarette smoke, is a major cause of skin damage. OBJECTIVES: To assess the effects of the small molecule polyphenol, honokiol, on reversing cigarette smoke-induced damage in vitro to relevant skin cells. METHODS: Keratinocytes (HaCat) cultures were exposed to cigarette smoke and, after 48 hours, IL-1α and IL-8 were measured in cell supernatants. Moreover, TIMP-2 production, apoptosis rate, and senescence β-galactosidase expression were evaluated in primary human foreskin fibroblasts (HFF-1) cultures...
February 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28196028/evaluation-of-suppressive-effects-of-tranilast-on-the-invasion-metastasis-mechanism-in-a-murine-pancreatic-cancer-cell-line
#3
Munehisa Kaneda, Hideaki Obara, Keiichi Suzuki, Osamu Takeuchi, Asako Takizawa, Masayoshi Osaku, Hajime Matsubara, Yuko Kitagawa
OBJECTIVES: Numerous studies have investigated the mechanism of the antitumor effect of tranilast, well known as an antiallergic drug. Herein, we investigated the mechanism of the antitumor effects of tranilast using murine Pan02 cell line. METHODS: In an allograft mouse model, the number of metastatic sites in the liver was counted. Wound healing and chemoinvasion assay were performed to evaluate migration and invasive ability of Pan02, respectively. Activities of matrix metalloproteinases (MMPs) were evaluated by gelatin zymography...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28186971/ensnaring-membrane-type-1-matrix-metalloproteinase-mt1-mmp-with-tissue-inhibitor-of-metalloproteinase-timp-2-using-the-haemopexin-domain-of-the-protease-as-a-carrier-a-targeted-approach-in-cancer-inhibition
#4
Bingjie Jiang, Yan Zhang, Jian Liu, Anastasia Tsigkou, Magdalini Rapti, Meng Huee Lee
Metastatic cancer cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to degrade the extracellular matrix in order to facilitate migration and proliferation. Tissue Inhibitor of Metalloproteinase (TIMP)-2 is the endogenous inhibitor of the MMP. Here, we describe a novel and highly effective fusion strategy to enhance the delivery of TIMP-2 to MT1-MMP. We can reveal that TIMP-2 fused to the haemopexin +/- transmembrane domains of MT1-MMP (two chimeras named T2PEX+TM and T2PEX) are able to interact with MT1-MMP on the cell surface as well as intracellularly...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28166590/the-effect-of-chrysin-loaded-plga-peg-on-metalloproteinase-gene-expression-in-mouse-4t1-tumor-model
#5
Zoheyr Mohammadi, Mohsen Sharif Zak, Khaled Seidi, Meisam Barati, Abolfazl Akbarzadeh, Nosratollah Zarghami
Despite the advances in medicine, cancer remains as one of the leading causes of the death worldwide. Through our previous study, the Chrysin loaded PGLA/PEG has been synthesized, and its physico-chemical properties were characterized. The aim of the present study was to evaluate the Chrysin loaded PGLA/PEG nanoparticle therapeutic effects on TIMP-1, TIMP-2, MMP-2, MMP-9 and PI3k expression in Mouse 4T1 breast tumor model.30 mice were enrolled in the current study, and the mice were randomly divided into 3 groups: untreated (n=10), Chrysin treatment (n=10) and Chrysin-loaded PLGA/PEG-based treatment (n=10)...
February 6, 2017: Drug Research
https://www.readbyqxmd.com/read/28164586/plasma-levels-and-diagnostic-utility-of-m-csf-mmp-2-and-its-inhibitor-timp-2-in-the-diagnostics-of-breast-cancer-patients
#6
Monika Zajkowska, Maciej Szmitkowski
BACKGROUND: M-CSF, MMP-2 and its inhibitor TIMP-2 may play a role in the pathogenesis and proliferation of breast cancer (BC). In this paper, plasma levels and the diagnostic utility of these parameters were investigated in comparison to CA 15-3 in patients with BC and in relation to the control groups: patients with benign breast tumor and healthy subjects. METHODS: Plasma levels of the tested parameters were determined using immunoenzyme assay (ELISA) and CA 15-3 with a chemiluminescence method (CMIA)...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28137415/analysis-of-mmp-7-and-timp-2-gene-polymorphisms-in-coronary-artery-disease-and-myocardial-infarction-a-turkish-case-control-study
#7
Ebru Alp, Akin Yilmaz, Murat Tulmac, Asiye Ugras Dikmen, Atiye Cengel, Ridvan Yalcin, Emine Sevda Menevse
Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7 A-181G (rs11568818), C-153T (rs11568819), C-115T (rs17886546), and TIMP-2 G-418C (rs8179090) polymorphisms have been studied in various diseases. However, association between coronary artery disease (CAD) and these polymorphisms has been poorly studied. The goal of this study is to investigate the association of CAD and myocardial infarction (MI) with MMP-7 or TIMP-2 polymorphisms...
February 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28131848/dehydroandrographolide-inhibits-oral-cancer-cell-migration-and-invasion-through-nf-%C3%AE%C2%BAb-ap-1-and-sp-1-modulated-matrix-metalloproteinase-2-inhibition
#8
Ming-Ju Hsieh, Jui-Chieh Chen, Wei-En Yang, Su-Yu Chien, Mu-Kuan Chen, Yu-Sheng Lo, Yi-Ting Hsi, Yi-Ching Chuang, Chia-Chieh Lin, Shun-Fa Yang
BACKGROUND AND PURPOSE: Oral cancer is a type of head and neck cancer that is characterized by cancerous tissue growth in the oral cavity. Andrographolide and dehydroandrographolide (DA) are the two principal components of Andrographis paniculata (Burm.f.) Nees and are the main contributors to its therapeutic properties. However, the pharmacological activities of DA remain unclear. EXPERIMENTAL APPROACH: In this study, we used wound closure assay and Boyden chamber assay to determine the effects of DA on oral cancer cell migration and invasion...
January 25, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28130030/biomarker-changes-in-anterior-cruciate-ligament-deficient-knees-compared-with-healthy-controls
#9
Daniel J Kaplan, Vanessa G Cuellar, Laith M Jazrawi, Eric J Strauss
PURPOSE: To establish how synovial fluid biomarker concentrations change in patients after anterior cruciate ligament (ACL) tears, with and without associated cartilage injury, with comparisons made to healthy controls. METHODS: Patients were prospectively enrolled between January 2013 and December 2014. Inclusion criteria included any patient undergoing knee arthroscopy. Patients with a confirmed ACL tear were allocated to either the ACL tear with cartilage injury group or the ACL tear without cartilage injury group based on intraoperative assessment...
January 24, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28121626/differential-expression-of-cd44-and-cd24-markers-discriminates-the-epitheliod-from-the-fibroblastoid-subset-in-a-sarcomatoid-renal-carcinoma-cell-line-evidence-suggesting-the-existence-of-cancer-stem-cells-in-both-subsets-as-studied-with-sorted-cells
#10
Chin-Hsuan Hsieh, Shih-Chieh Hsiung, Chi-Tai Yeh, Chih-Feng Yen, Yah-Huei Wu Chou, Wei-Yi Lei, See-Tong Pang, Cheng-Keng Chuang, Shuen-Kuei Liao
Epithelioid and fibroblastoid subsets coexist in the human sarcomatoid renal cell carcinoma (sRCC) cell line, RCC52, according to previous clonal studies. Herein, using monoclonal antibodies to CD44 and CD24 markers, we identified and isolated these two populations, and showed that CD44bright/CD24dim and CD44bright/CD24bright phenotypes correspond to epithelioid and fibroblastoid subsets, respectively. Both sorted subsets displayed different levels of tumorigenicity in xenotransplantation, indicating that each harbored its own cancer stem cells (CSCs)...
January 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118605/boosting-the-hypoxic-response-in-myeloid-cells-accelerates-resolution-of-fibrosis-and-regeneration-of-the-liver-in-mice
#11
Chahrazade Kantari-Mimoun, Ewelina Krzywinska, Magali Castells, Corinne Milien, Ralph Klose, Anna-Katharina Meinecke, Ursula Lemberger, Thomas Mathivet, Milos Gojkovic, Katrin Schrödter, Christoph Österreicher, Joachim Fandrey, Helene Rundqvist, Christian Stockmann
We have recently shown that targeting Vascular Endothelial Growth Factor (VEGF) specifically in scar-infiltrating myeloid cells prevented remodeling of the sinusoidal vasculature and abrogated the resolution of murine liver fibrosis, thereby unmasking an unanticipated link between angiogenesis and resolution of fibrosis. In a gain of function approach, we wanted to test the impact of VEGF overexpression in myeloid cells on fibrolysis. We observe that genetic inactivation of the von Hippel Lindau protein (VHL), a negative regulator of Hypoxia-inducible factors (HIF) in myeloid cells, leads to increased VEGF expression and most importantly, accelerated matrix degradation and reduced myofibroblast numbers after CCl4 challenge...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118321/propofol-suppresses-esophageal-squamous-cell-carcinoma-cell-migration-and-invasion-by-down-regulation-of-sex-determining-region-y-box-4-sox4
#12
Chun-Li Zhou, Jing-Jing Li, Peng Ji
BACKGROUND This study was done to verify whether propofol could inhibit esophageal squamous cell carcinoma (ESCC) cell line EC9706 cell migration and invasion by targeting SOX4. MATERIAL AND METHODS Different concentrations of propofol were co-incubated with EC9706 cells. The pcDNA-SOX4 or SOX4 siRNA plasmid was transfected into cells before the treatment with propofol 5 µg/L. The migratory and invasion ability of EC9706 cells were tested by wound-healing assay and Transwell chambers. Western blotting was used to investigate the expressions of MMP-2, MMP-9, TIMP-1, TIMP-2, and SOX4...
January 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28110412/prevention-of-cardiac-surgery-associated-aki-by-implementing-the-kdigo-guidelines-in-high-risk-patients-identified-by-biomarkers-the-prevaki-randomized-controlled-trial
#13
Melanie Meersch, Christoph Schmidt, Andreas Hoffmeier, Hugo Van Aken, Carola Wempe, Joachim Gerss, Alexander Zarbock
PURPOSE: Care bundles are recommended in patients at high risk for acute kidney injury (AKI), although they have not been proven to improve outcomes. We sought to establish the efficacy of an implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guidelines to prevent cardiac surgery-associated AKI in high risk patients defined by renal biomarkers. METHODS: In this single-center trial, we examined the effect of a "KDIGO bundle" consisting of optimization of volume status and hemodynamics, avoidance of nephrotoxic drugs, and preventing hyperglycemia in high risk patients defined as urinary [TIMP-2]·[IGFBP7] > 0...
January 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28107490/diagnostic-value-of-urine-tissue-inhibitor-of-metalloproteinase-2-and-insulin-like-growth-factor-binding-protein-7-for-acute-kidney-injury-a-meta-analysis
#14
Yuanyuan Su, Zhiyan Gong, Yan Wu, Yuan Tian, Xiaohui Liao
BACKGROUND: Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein-7 (IGFBP7) are both involved in renal tubular epithelial cell cycle arrest in acute kidney injury (AKI). Several recent studies showed that urine TIMP-2 times IGFBP7 ([TIMP-2]*[IGFBP7]) is a promising biomarker to predict AKI. METHODS: The aim of this meta-analysis was to assess the diagnostic value of urine [TIMP-2]*[IGFBP7] for early diagnosis of AKI. Relevant studies were retrieved from the PubMed, EMBASE, and Cochrane Library databases...
2017: PloS One
https://www.readbyqxmd.com/read/28098862/rhein-suppresses-matrix-metalloproteinase-production-by-regulating-the-rac1-ros-mapk-ap-1-pathway-in-human-ovarian-carcinoma-cells
#15
Guomei Zhou, Fenghui Peng, Yanping Zhong, Yanhua Chen, Min Tang, Danrong Li
Matrix metalloproteinases (MMPs) are a family of calcium-dependent zinc-containing endopeptidases, which play an integral role in migration and invasion of ovarian cancer. Rac1 proteins might mostly influence cell migration and invasion by generating endogenous reactive oxygen species. Therefore, inhibiting MMPs and regulating the Rac1/ROS/MAPK/AP-1 pathway may be a new therapeutic strategy for ovarian cancer. In this study, we found that rhein could suppress the invasion and migration of SKOV3-PM4 cells with characteristics of directional highly lymphatic metastasis...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098856/anti%C3%A2-wrinkle-effect-of-fermented-black-ginseng-on-human-fibroblasts
#16
Quynh Lien Pham, Hyun-Jun Jang, Kyu-Bong Kim
Fermented black ginseng (FBG) is processed by the repeated steaming and drying of fresh ginseng followed by fermentation with Saccharomyces cerevisiae. It is known to possess anti‑oxidative effects. Skin wrinkle formation is associated with oxidative stress and inflammatory reactions. The aim of this study was to determine whether FBG possesses anti‑wrinkle activity using human fibroblasts (HS68). According to the Korea Ministry of Food and Drug Safety (MFDS) guidelines for the evaluation of the efficacy of functional anti‑wrinkle cosmetics, we attempted to elucidate the effects of FBG on type I procollagen, matrix metalloproteinase (MMP)‑1, MMP‑2, MMP‑9 and tissue inhibitor of metalloproteinase‑2 (TIMP‑2)...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28090659/the-effect-of-intradetrusor-botulinum-neurotoxin-type-a-on-urinary-ngf-tgf-beta-1-timp-2-levels-in-children-with-neurogenic-detrusor-overactivity-due-to-myelodysplasia
#17
Tuncay Top, Cagri Akin Sekerci, Banu Isbilen-Basok, Yiloren Tanidir, Ilker Tinay, Ferruh Kemal Isman, Cem Akbal, Ferruh Simsek, Tufan Tarcan
AIMS: The aim of this study was to determine the value of urine nerve growth factor (NGF), transforming growth factor beta 1 (TGF-Beta-1), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) levels to predict the urodynamic profile before and after botulinum neurotoxin type A (BoNT-A) treatment in children with myelodysplasia. METHODS: This prospective study included 15 children with myelodysplasia who underwent intradetrusor BoNT-A injections due to neurogenic detrusor overactivity (NDOA)...
January 16, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28076311/biomarkers-of-acute-kidney-injury-the-pathway-from-discovery-to-clinical-adoption
#18
Kianoush Kashani, Wisit Cheungpasitporn, Claudio Ronco
Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant impact on outcomes, including mortality and morbidities. Unfortunately, apart from prophylactic measures, no effective treatment for this syndrome is known. Therefore, early recognition of AKI not only can provide better opportunities for preventive interventions, but also opens many gates for research and development of effective therapeutic options. Over the last few years, several new AKI biomarkers have been discovered and validated to improve early detection, differential diagnosis, and differentiation of patients into risk groups for progressive renal failure, need for renal replacement therapy (RRT), or death...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28075447/anti-metastatic-effect-of-rhodomyrtone-from-rhodomyrtus-tomentosa-on-human-skin-cancer-cells
#19
Malatee Tayeh, Sirinun Nilwarangoon, Wilawan Mahabusarakum, Ramida Watanapokasin
This study focused on the inhibitory effect of rhodomyrtone, a bioactive compound isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk., on cancer metastasis in epidermoid carcinoma A431 cells and on the verification of the underlying related molecular mechanisms of this event. We demonstrated that rhodomyrtone at the subcytotoxic concentration (0.5 and 1.5 µg/ml) exhibited pronounced inhibition of cancer metastasis by reducing cell migration, cell adhesive ability and cell invasion of A431 cells in a dose-dependent manner...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28050662/metalloproteinases-and-their-inhibitors-in-patients-with-inguinal-hernia
#20
Arda Isik, Cebrail Gursul, Kemal Peker, Merve Aydın, Deniz Fırat, İsmayil Yılmaz
AIM: The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). MATERIALS AND METHODS: This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients...
January 3, 2017: World Journal of Surgery
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