keyword
MENU ▼
Read by QxMD icon Read
search

TIMP-2

keyword
https://www.readbyqxmd.com/read/28693294/upregulated-expression-of-mmp-9-in-gingival-epithelial-cells-induced-by-prolonged-stimulation-with-arecoline
#1
Osamu Uehara, Kousuke Takimoto, Tetsuro Morikawa, Fumiya Harada, Rie Takai, Bhoj Raj Adhikari, Ryoko Itatsu, Tomohisa Nakamura, Koki Yoshida, Hirofumi Matsuoka, Hiroki Nagayasu, Ichiro Saito, Malsantha Muthumala, Itsuo Chiba, Yoshihiro Abiko
Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed. The HGEPs were alternated between 3 days of incubation with arecoline (50 µg/ml), and 3 days without arecoline, for up to 30 days...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693193/allicin-inhibits-the-invasion-of-lung-adenocarcinoma-cells-by-altering-tissue-inhibitor-of-metalloproteinase-matrix-metalloproteinase-balance-via-reducing-the-activity-of-phosphoinositide-3-kinase-akt-signaling
#2
Ling Huang, Yuanhong Song, Jianping Lian, Zhiwei Wang
Allicin, the main active principle associated with Allium sativum chemistry, has various antitumor activities. However, to the best of our knowledge, there is no available information to address the anti-invasive effect and associated mechanism in lung adenocarcinoma. In the present study, cell viability assay, cell adhesion assay, western blot analysis, Transwell migration and invasion assays and reverse transcription-quantitative polymerase chain reaction were performed. Allicin was identified to inhibit the adhesion, invasion and migration of lung adenocarcinoma cells in a dose-dependent manner, accompanied by decreasing mRNA and protein levels of matrix metalloproteinase (MMP)-2 and MMP-9...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28682920/the-diagnostic-accuracy-of-urinary-timp-2-%C3%A2-igfbp7-for-acute-kidney-injury-in-adults-a-prisma-compliant-meta-analysis
#3
Chao Liu, Xiaochun Lu, Zhi Mao, Hongjun Kang, Hui Liu, Liang Pan, Jie Hu, Li Wang, Feihu Zhou
INTRODUCTION: Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed this meta-analysis to assess the diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for AKI in adult patients. METHODS: We searched the PubMed, Embase, and Cochrane Library databases from database inception to March 2017...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682294/proteomic-comparison-of-amnion-and-chorion-and-evaluation-of-the-effects-of-processing-on-placental-membranes
#4
John P McQuilling, Jeremy B Vines, Kelly A Kimmerling, Katie C Mowry
OBJECTIVE: The purpose of this study is to compare the growth factor and cytokine content found within the amnion and chorion layers and to determine the effects of dehydration on them. MATERIALS AND METHODS: Placentas were collected from 5 to 6 consented donors following elective cesarean section, and 1-cm2 sections of either amnion or chorion were immediately stored at -80°C or dehydrated prior to -80°C storage until proteomic analysis. Signaling molecules from tissue samples were evaluated using quantitative multiplex proteomics microarrays, and data were analyzed based on a per cm2 basis and also on pg/mg of extracted protein for potency...
June 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28681084/photobiomodulation-therapy-action-in-wound-repair-skin-induced-in-aged-rats-old-time-course-of-biomarkers-inflammatory-and-repair
#5
Franciane Barbieri Fiorio, Solange Almeida Dos Santos, Caroline Sobral de Melo Rambo, Camila Guerra Dalbosco, Andrey Jorge Serra, Brunno Lemes de Melo, Ernesto Cesar Pinto Leal-Junior, Paulo de Tarso Camillo de Carvalho
Previous studies have discussed an inverse correlation between age and wound healing, because it relates to the association of aging with a gradual decrease in healing capacity. Treatment with photobiomodulation therapy (PBMT) improves wound healing by inducing increases in mitotic activity, numbers of fibroblasts, collagen synthesis, and neovascularization. Therefore, this study aimed to evaluate the effects of PBMT in cutaneous wound healing in aged rats. A punch biopsy of 8 mm in diameter was performed to produce a skin wound...
July 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28674842/clinical-relevance-and-predictive-value-of-damage-biomarkers-of-drug-induced-kidney-injury
#6
Sandra L Kane-Gill, Pamela L Smithburger, Kianoush Kashani, John A Kellum, Erin Frazee
Nephrotoxin exposure accounts for up to one-fourth of acute kidney injury episodes in hospitalized patients, and the associated consequences are as severe as acute kidney injury due to other etiologies. As the use of nephrotoxic agents represents one of the few modifiable risk factors for acute kidney injury, clinicians must be able to identify patients at high risk for drug-induced kidney injury rapidly. Recently, significant advancements have been made in the field of biomarker utilization for the prediction and detection of acute kidney injury...
July 3, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28662337/danshen-attenuates-osteoarthritis-related-cartilage-degeneration-through-inhibition-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-vivo-and-in-vitro
#7
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Danshen is a traditional Chinese medicine herb that can alleviate osteoarthritis (Soder et al.) symptoms in animals. However, the underlying mechanisms remain poorly understood and require further investigation. In this study, rabbits with experimental OA were given intra-articular injection of Danshen (0.7 mL/day) for five weeks. In addition to attenuating the cartilage degeneration of OA rabbits, Danshen decreased the expression and activity of matrix metalloproteinase 9 (MMP-9) and MMP-13, whereas increased that of their natural inhibitors, tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and TIMP-2...
June 29, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28662285/genetic-predisposition-for-chronic-venous-insufficiency-in-several-genes-for-matrix-metalloproteinases-mmp-2-mmp-9-mmp-12-and-their-inhibitor-timp-2
#8
V Slonková, V Slonková, A Vašků, V Vašků
OBJECTIVE: The project was scheduled as a case-control study to investigate the correlation between MMP-2 (rs243864), MMP-9 (3918242), MMP-12 (rs7123600) and TIMP-2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP-2 genotypes and phenotypes of CVD. MATERIAL AND METHODS: 150 CVD patients and 227 controls were enrolled into the study. The MMPs and TIMP-2 genotypes were identified by the PCR method and restriction analysis according to standard protocols...
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28659595/cellular-uptake-of-prommp-2-timp-2-complexes-by-the-endocytic-receptor-megalin-lrp-2
#9
Manuel Johanns, Pascale Lemoine, Virginie Janssens, Giuseppina Grieco, Soren K Moestrup, Rikke Nielsen, Erik I Christensen, Pierre J Courtoy, Hervé Emonard, Etienne Marbaix, Patrick Henriet
Matrix metalloproteinases (MMPs) are regulated at multiple transcriptional and post-transcriptional levels, among which receptor-mediated endocytic clearance. We previously showed that low-density lipoprotein receptor-related protein-1 (LRP-1) mediates the clearance of a complex between the zymogen form of MMP-2 (proMMP-2) and tissue inhibitor of metalloproteinases, TIMP-2, in HT1080 human fibrosarcoma cells. Here we show that, in BN16 rat yolk sac cells, proMMP-2:TIMP-2 complex is endocytosed through a distinct LRP member, megalin/LRP-2...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28656271/role-of-transforming-growth-factor-%C3%AE-%C3%A2-1-in-the-pathogenesis-of-pelvic-organ-prolapse-a-potential-therapeutic-target
#10
Cheng Liu, Ying Wang, Bing-Shu Li, Qing Yang, Jian-Ming Tang, Jie Min, Sha-Sha Hong, Wen-Jun Guo, Li Hong
The present study aimed to reveal the metabolic alterations of the extracellular matrix (ECM) in uterosacral ligament (USL) with pelvic organ prolapse (POP) and to explore the role of transforming growth factor‑β1 (TGF‑β1) in pathogenesis of POP. For this purpse, 60 participants who underwent hysterectomy for benign indications were enrolled, 30 of which had symptomatic POP (grade II, III or IV) and composed the POP group, and the other 30 had asymptomatic POP (grade I or less) and served as the controls...
June 26, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28646585/prognostic-value-of-cell-cycle-arrest-biomarkers-in-patients-at-high-risk-for-acute-kidney-injury-a-systematic-review-and-meta-analysis
#11
REVIEW
Hui-Miao Jia, Li-Feng Huang, Yue Zheng, Wen-Xiong Li
AIM: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are G1 cell cycle arrest biomarkers. This systematic review aimed to evaluate the prognostic value of urinary [TIMP-2]·[IGFBP7] in patients at high risk for AKI. METHODS: The MEDLINE (via PubMed), Ovid, EMBASE and Cochrane Library databases were systematically searched from inception to December 25, 2016. Original clinical studies which met the eligibility criteria were included in this study...
June 24, 2017: Nephrology
https://www.readbyqxmd.com/read/28627739/use-of-a-protein-engineering-strategy-to-overcome-limitations-in-the-production-of-difficult-to-express-recombinant-proteins
#12
Hirra Hussain, David I Fisher, W Mark Abbott, Robert G Roth, Alan J Dickson
Certain recombinant proteins are deemed "difficult to express" in mammalian expression systems requiring significant cell and/or process engineering to abrogate expression bottlenecks. With increasing demand for the production of recombinant proteins in mammalian cells, low protein yields can have significant consequences for industrial processes. To investigate the molecular mechanisms that restrict expression of recombinant proteins, naturally secreted model proteins were analysed from the tissue inhibitors of metalloproteinase (TIMP) protein family...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28601470/tissue-and-serum-mrna-profile-of-mmps-2-9-as-a-potential-novel-biomarker-for-the-most-individual-approach-in-infantile-hemangiomas-and-cancer-disease
#13
Katarzyna Taran, Aneta Wnęk, Józef Kobos, Ewa Andrzejewska, Przemysław Przewratil
Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propranolol influences their pathways. However, a number of MMPs studies is highly limited. Here, for the first time, we propose a comprehensive approach by analyzing the expression levels of metalloproteinases-2/9 (MMPs-2/9) and tissue metalloproteinase inhibitor-2 (TIMP-2) in vivo on both, molecular and immunohistochemical levels, and in both, IH tissues and in the serum of IH patients, and relates the obtained results to the tumor's biology and systemic propranolol treatment...
June 3, 2017: Immunobiology
https://www.readbyqxmd.com/read/28600524/disruption-of-retinal-pigment-epithelial-cell-properties-under-the-exposure-of-cotinine
#14
Xiao-Yu Zhang, Tsz Kin Ng, Mårten Erik Brelén, Kwok Ping Chan, Di Wu, Jasmine Sum Yee Yung, Di Cao, Yumeng Wang, Shaodan Zhang, Sun On Chan, Chi Pui Pang
Cigarette smoking is a major risk factor for age-related macular degeneration (AMD), in which progressive retinal pigment epithelial (RPE) cell degeneration is a major pathological change. Nicotine is a major biologically active component in cigarette smoke. It is continuously catabolized into cotinine, which has longer half-life and higher concentration in tissue cells and fluids. Here we hypothesized that continuous exposure of cotinine has more potent effects on human RPE cell properties than nicotine. Human RPE cell line (ARPE-19) was treated continuously with 1-2 µM of nicotine and/or cotinine for 7 days...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587339/orf3-as-a-sensitive-and-specific-diagnostic-index-for-hepatitis-e
#15
Lijuan Li, Min Liu, Chengrui Geng, Yunmei Zou, Tong Jiao
We explored the significance of the expression of hepatitis E virus (HEV) open reading frame 3 (ORF3) in hepatitis E rat models. We also investigated its diagnostic value. Forty Sprague-Dawley (SD) rats were infected with HEV and 10 uninfected rats were selected for the control group. Rats were sacrificed at 14, 21, 35 and 70 days after infection. They were divided into 4 groups: Model group 1, model group 2, model group 3 and model group 4. ORF3 protein expression level in liver tissue, level of adipokines [fatty acid synthase (FAS), tissue inhibitor of metalloproteinase-2 (TIMP-2) and angiotensin-converting enzyme inhibitor 2 (ACE-2)], Th1/Th2 cells balance [interferon (IFN), interleukin-4 (IL-4) and Th1/Th2] and the level of immune outcome (levels of CD4(+), CD8(+) T lymphocytes and CD4(+)/CD8(+)) were measured and compared among groups...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586031/punicalagin-suppresses-the-proliferation-and-invasion-of-cervical-cancer-cells-through-inhibition-of-the-%C3%AE-catenin-pathway
#16
Jianming Tang, Bingshu Li, Shasha Hong, Cheng Liu, Jie Min, Ming Hu, Yang Li, Yaodan Liu, Li Hong
Natural botanical drugs have attracted attention due to their cancer chemopreventive and chemotherapeutic properties in cancer. Punicalagin (PUN) is the major bioactive component of pomegranate peel, and has been shown to have antioxidant, anti-inflammatory, antiviral, antiproliferation and anticancer properties. PUN has been shown to induce apoptosis in several cancer cell lines. The aim of the present study was to investigate the effect of PUN on HeLa human cervical cancer cells in vitro. The viability of the HeLa cells was assessed following treatment with PUN (0, 12...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28576405/protective-effects-of-donepezil-against-endothelial-permeability
#17
Xuelu Tang, Xiuhua Di, Yilin Liu
The endothelium lines the interior surface of blood vessels, and under pathophysiologic conditions, its integrity can be compromised due to a disturbance in the expression of tight junctions. Donepezil is a licensed drug used in the palliative treatment of Alzheimer's disease (AD). Increasing evidence has reported that donepezil has an anti-inflammatory activity. However, little information is available regarding the role of donepezil in vascular diseases. In this study, we found that pretreatment with donepezil significantly ameliorated endothelial permeability induced by tumor necrosis factor (TNF-α) by restoring the expression of the tight junction proteins vascular endothelial cadherin (VE-cadherin) and zonula occludens-1 (ZO-1) in human umbilical vein endothelial cells (HUVECs)...
May 30, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28575805/niclosamide-induces-apoptosis-through-mitochondrial-intrinsic-pathway-and-inhibits-migration-and-invasion-in-human-thyroid-cancer-in-vitro
#18
Kai Yu, Tingting Wang, Yujue Li, Chun Wang, Xia Wang, Mei Zhang, Yongmei Xie, Shuangqing Li, Zhenmei An, Tinghong Ye
The morbidity of thyroid cancer has been rising obviously throughout the world during the past years. Classic treatment procedure is generally curable for low risk differentiated thyroid cancer, but may lead to many postoperative complications. And low-level of thyroid stimulating hormone after surgery has side effects on both cardiovascular system and skeletal system. Furthermore effective treatment approaches for more aggressive differentiated thyroid cancer, poorly differentiated thyroid cancer and anaplastic thyroid cancer are absent, thus new candidates that can inhibit tumor growth and metastasis are urgently needed...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28573088/matrix-metalloproteases-and-their-tissue-inhibitors-in-non-alcoholic-liver-fibrosis-of-human-immunodeficiency-virus-infected-patients
#19
Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón, Víctor Asensi
AIM: To investigate the relationships among diverse metalloproteases (MMPs) and their tissue inhibitors (TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus (HIV)-infected patients. METHODS: Single nucleotide polymorphisms (SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus (HCV) coinfection. A total of 158 patients were included, 57 of whom were HCV-coinfected...
May 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/28558754/urinary-timp-2-and-igfbp7-for-the-prediction-of-acute-kidney-injury-following-cardiac-surgery
#20
Yimei Wang, Zhouping Zou, Jifu Jin, Jie Teng, Jiarui Xu, Bo Shen, Wuhua Jiang, Yamin Zhuang, Lan Liu, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding
BACKGROUND: Acute kidney injury (AKI) following cardiac surgery is common and associated with poor patient outcomes. Early risk assessment for development of AKI remains a challenge. The combination of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) has been shown to be an excellent predictor of AKI following cardiac surgery, but reported studies are for predominately non-Asian populations. METHODS: Adult patients were prospectively enrolled at Zhongshan hospital in Shanghai, China...
May 30, 2017: BMC Nephrology
keyword
keyword
109186
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"