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https://www.readbyqxmd.com/read/29777769/a-combined-approach-for-the-early-recognition-of-acute-kidney-injury-after-adult-cardiac-surgery
#1
Cédrick Zaouter, Julien Potvin, Marie-Lise Bats, Marie-Christine Beauvieux, Alain Remy, Alexandre Ouattara
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication. The current criteria to detect CSA-AKI rise only when organic dysfunction has occurred. The Doppler Renal Resistive Index (RRI) and the urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) have been advocated to predict CSA-AKI at an early stage after cardiac surgery. The primary objective was to determine the predictive value of these new markers to detect CSA-AKI after elective heart surgery in patients at risk to develop AKI...
May 16, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#2
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29770894/efficacy-of-punarnavine-in-restraining-organ-specific-tumour-progression-in-4t1-induced-murine-breast-tumour-model
#3
Gilcy George Kallivalappil, Girija Kuttan
Most of the breast cancer deaths occur when cancer cells depart from their tumour of origin and spread systemically and colonise distant organs. The present study was to find out whether punarnavine, the quinolizidine alkaloid, with already proven antimetastatic effect on spontaneous B16F10 pulmonary metastasis has got any effect on a drastic organ-specific breast cancer spread. For the study, we selected a syngenic mouse 4T1 breast tumour model that mimics stage four of human breast cancer. The metastatic progression of 4T1 to lymph nodes, lungs, and liver was reduced by punarnavine (40 mg/kg body weight) administration in BALB/c mice...
May 17, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29769086/inflammatory-pattern-of-the-infrapatellar-fat-pad-in-dogs-with-canine-cruciate-ligament-disease
#4
Manuel R Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E Spreng, Simone Forterre
BACKGROUND: Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthritis, the infrapatellar fat pad (IFP) was up to now mostly disregarded in veterinary investigations. In the present study, the inflammatory activity of the IFP, the main adipose structure within the stifle joint, was thoroughly investigated to evaluate its potential impact in the pathogenesis of this common disease of our canine companions...
May 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29760617/roc-analysis-of-selected-matrix-metalloproteinases-mmps-and-tissue-inhibitors-of-metalloproteinases-timps-in-psoriatic-patients
#5
Edyta K Glazewska, Marek Niczyporuk, Slawomir Lawicki, Maciej Szmitkowski, Monika Zajkowska, Magdalena Donejko, Andrzej Przylipiak
Introduction: Psoriasis is a common, chronic inflammatory disease characterised by typical scaly skin lesions. The role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the pathogenesis and development of this condition have been repeatedly emphasised in available literature. Aim: ROC analysis of selected MMPs (MMP-2, MMP-3, MMP-9, MMP-12, TIMP-2) and TIMPs (TIMP-2, TIMP-3) in psoriasis patients. The area under the ROC curve (AUC) indicates the clinical usefulness of a biomarker and its diagnostic power...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29759660/extensive-serum-biomarker-analysis-in-patients-with-nasopharyngeal-carcinoma
#6
Daoyuan Gong, Ziping Li, Rui Ding, Min Cheng, Huakun Huang, Aiping Liu, Mei Kang, Haijian He, Ying Xu, Jing Shao, Yong Wang, Chaohui Duan
Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC patient serum using a solid-phase antibody array detecting the expression profiles of 174 cytokines in a single experiment. ELISA was performed to validate the array results. The levels of TIMP-2, SELL, CCL24, MMP-1, MMP-3, IGF-I and IL-8 were significantly higher in serum from NPC patients, while the levels of MSP-alpha and HCC-4 were lower...
May 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29753285/chitin-synthesis-inhibitors-promote-liver-cancer-cell-metastasis-via-interfering-with-hypoxia-inducible-factor-1%C3%AE
#7
Xia Ning, Yue Wang, Wei Yan, Guangke Li, Nan Sang
Chitin synthesis inhibitors (CSIs), as alternatives to conventional insecticides, have been in worldwide demand in recent years. However, little attention has been paid to the potential ecological safety and health risks of CSIs, especially their abilities to interfere with nonsexual hormone receptors such as hypoxia-inducible factor 1α (HIF-1α). In this work, we conducted a systematic study regarding the influence of CSIs on HIF-1α-related liver cancer cell metastasis. The dual-luciferase reporter gene assay revealed that two of fourteen CSIs exhibited dose-response HIF-1α agonistic activities at noncytotoxic concentrations with relative luciferase activity (RLA) values of 25...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753168/serum-timp1-and-timp2-concentration-in-patients-with-different-grades-of-meningioma
#8
Farhad Mashayekhi, Alia Saberi, Sohail Mashayekhi
OBJECTIVE: Meningiomas are common primary brain tumors that constitute about 13% of all intracranial tumors. Matrix metalloproteinase-9 (MMP-9) is able to degrade the extracellular matrix and basement membrane leading to cancer cell invasion and metastasis. MMPs are specifically inhibited by a family of small extracellular proteins known as the tissue inhibitors of metalloproteinases (TIMPs). The objective of this project was to evaluate serum concentration of TIMP-1 and TIMP-2 in patients with different grades of meningioma...
May 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29751827/timp-2-igfbp7-predicts-acute-kidney-injury-in-out-of-hospital-cardiac-arrest-survivors
#9
Christoph Adler, Tobias Heller, Felix Schregel, Henning Hagmann, Martin Hellmich, Joana Adler, Hannes Reuter
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiopulmonary resuscitation (CPR) and predicts in-hospital mortality. To which extent post-resuscitation disease or the initial event of cardiac arrest and the duration of insufficient cardiac output triggers AKI is challenging to discriminate. Knowledge on molecular mediators of AKI is scarce. Early identification of patients at high risk of AKI is hampered by the low sensitivity of the established tests in clinical routine practice...
May 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29751513/-lactobacillus-casei-strain-shirota-enhances-the-in-vitro-antiproliferative-effect-of-geniposide-in-human-oral-squamous-carcinoma-hsc-3-cells
#10
Yu Qian, Jia-Le Song, Peng Sun, Ruokun Yi, Honglin Liu, Xia Feng, Kun-Young Park, Xin Zhao
This study investigated the enhanced antiproliferative effect of Lactobacillus casei strain Shirota (LcS) on geniposide actions in human oral squamous carcinoma HSC-3 cells. An MTT assay, flow cytometry, qPCR assay, western blot and HPLC were used for this study. The concentration of 1.0 × 10⁶ CFU/mL of LcS had no effect on the HOK normal oral epithelial cells and HSC-3 cancer cells. The 25 and 50 µg/mL geniposide concentrations also had no impact on HOK normal oral epithelial cells, but they had remarkable inhibitory effects on the growth of HSC-3 cancer cells, which are enhanced in the presence of LcS...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29749494/downregulation-of-rpn2-induces-apoptosis-and-inhibits-migration-and-invasion-in-colon-carcinoma
#11
Chongyao Bi, Baofei Jiang
The morbidity of colorectal cancer (CRC) increases annualy, which accounts to higher mortality worldwide. Therefore, it is important to study the pathogenesis of colon cancer. Ribophorin II (RPN2), part of the N-oligosaccharyltransferase complex, is highly expressed in CRC. In the present study, we investigated whether RPN2 can regulate apoptosis, migration and invasion by RNA interference in CRC and sought to clarify the molecular mechanism involved. Based on previous research, an abnormal high expression of RPN2 was observed in CRC tissues and cell lines by real-time (RT)-PCR, immunohistochemistry (IHC) and western blot analysis...
May 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29745252/changes-in-the-pattern-of-fibrosis-in-the-rat-lung-with-repetitive-orotracheal-instillations-of-gastric-contents-evidence-of-persistent-collagen-accumulation
#12
Pedro Ayala, Jorge Torres, Raul Vivar, Pablo R Olmos, Manuel Meneses, Gisella R Borzone
Recurrent aspiration of gastric contents has been associated with several interstitial lung diseases. Despite this association, the pathogenic role of aspiration in these diseases has been poorly studied and little is known about extracellular matrix (ECM) changes in animal models of repetitive events of aspiration. Our aim was to study the repair phase of lung injury induced by each of several instillations of gastric fluid in Sprague-Dawley rats to evaluate changes in ECM and their reversibility. Anesthetized animals received weekly orotracheal instillations of gastric fluid for 1, 2, 3 and 4 weeks and were sacrificed at day 7 after last instillation...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29710527/sodium-butyrate-abolishes-the-degradation-of-type-ii-collagen-in-human-chondrocytes
#13
Wang Bo, Juan Zhou, Kunzheng Wang
Excessive expression of matrix metalloproteinases (MMPs) induced by pro-inflammatory cytokines such as interleukin-1β (IL-1β) has been associated with destruction of the articular cartilage matrix in chondrocytes from patients with osteoarthritis (OA). Among the MMPs, MMP-1, MMP-3 and MMP-13 participate in the degradation of type II collagen, the main component of the extracellular matrix in articular cartilage. Sodium butyrate is a bacterial metabolite used in the treatment of inflammatory diseases. However, the effects of sodium butyrate on the expression of MMPs and degradation of type II collagen has not been explored...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29687789/overexpression-of-myosin-phosphatase-target-subunit-1-mypt1-inhibits-tumor-progression-and-metastasis-of-gastric-cancer
#14
Fengyong Wang, Yuanshui Sun
BACKGROUND Myosin phosphatase target subunit 1 (MYPT1) serves as a subgroup of myosin phosphatases, and is frequently low-expressed in human cancers. However, little is known about the effects of MYPT1 in gastric cancer (GC). MATERIAL AND METHODS In our study, MYPT1 expression was detected by quantitative real-time reverse transcription PCR (qRT-PCR) in GC tissues, different advanced pathological stages of GC tissues, and preoperative and postoperative patients. Kaplan-Meier analysis was used to measure the overall survival of GC patients...
April 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29681903/inflammatory-mediator-profiles-differ-in-sepsis-patients-with-and-without-bacteremia
#15
Knut Anders Mosevoll, Steinar Skrede, Dagfinn Lunde Markussen, Hans Rune Fanebust, Hans Kristian Flaatten, Jörg Aßmus, Håkon Reikvam, Øystein Bruserud
Systemic levels of cytokines are altered during infection and sepsis. This prospective observational study aimed to investigate whether plasma levels of multiple inflammatory mediators differed between sepsis patients with and those without bacteremia during the initial phase of hospitalization. A total of 80 sepsis patients with proven bacterial infection and no immunosuppression were included in the study. Plasma samples were collected within 24 h of hospitalization, and Luminex® analysis was performed on 35 mediators: 16 cytokines, six growth factors, four adhesion molecules, and nine matrix metalloproteases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29621747/changes-in-biomarker-profile-and-left-ventricular-hypertrophy-regression-results-from-the-frequent-hemodialysis-network-trials
#16
Christopher T Chan, George A Kaysen, Gerald J Beck, Minwei Li, Joan Lo, Michael V Rocco, Alan S Kliger
BACKGROUND: Regression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials. METHODS: This was a post hoc observational cohort study. We hypothesized LVH regression with frequent HD was associated with a different cardiovascular biomarker profile. Regressors were defined as patients who achieved a reduction of more than 10% in LVM at 12 months...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29620263/tpx2-silencing-mediated-by-joint-action-of-microvesicles-and-ultrasonic-radiation-inhibits-the-migration-and-invasion-of-skov3-cells
#17
Dong Huang, Jianmin Chen, Cuiyu Yang, Minzhen Wang
Ovarian cancer, with its high morbidity, has one of the highest mortality rates among gynecological malignant tumors. Overexpression of targeting protein for Xklp2 (TPX2) has been identified in numerous malignant tumors. The present study sought to determine whether TPX2 silencing inhibited the growth and metastasis of ovarian cancer cells, and whether microvesicles‑ and ultrasonic radiation‑mediated small interfering (si)RNA‑TPX2 transfection may improve the therapeutic effect. The SKOV3 cell line, derived from papillary serous cytadenocarcinoma of the human ovary, was selected as a cell model...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620182/response-of-decorin-to-different-intensity-treadmill-running
#18
Shao-Yong Xu, Sheng-Yao Liu, Lei Xu, Song-Yun Deng, Yong-Bin He, Shu-Fen Li, Guo-Xin Ni
Decorin is widely understood to affect collagen fibrillogenesis. However, little is understood about its response to various mechanical loading conditions. In the present study, 36 Wistar rats were randomly divided into control (CON), moderate treadmill running (MTR) and strenuous treadmill running (STR) groups. Animals in the MTR and STR groups were subjected to a 4‑ or 8‑week treadmill running protocol. Subsequently, all Achilles tendons were harvested to perform histological and biochemical analyses...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29607740/effects-of-nano-encapsulated-curcumin-chrysin-on-telomerase-mmps-and-timps-gene-expression-in-mouse-b16f10-melanoma-tumour-model
#19
Fatemeh Tavakoli, Rana Jahanban-Esfahlan, Khaled Seidi, Masoumeh Jabbari, Ramezan Behzadi, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
Due to the high rate of drug resistance among malignant melanoma cases, it seems necessary to introduce an efficient pharmaceutical approach to melanoma treatment. For this purpose, Curcumin (Cur) and Chrysin (Chr), two natural anti-cancers, were co-encapsulated in PLGA-PEG nanoparticles (NPs), characterized by DLS, FTIR and FE-SEM and investigated for their effects on MMPs, TIMPs and TERT genes expression in C57B16 mice bearing B16F10 melanoma tumours. The results showed that the expression of MMP-9, MMP-2 and TERT genes were significantly decreased in all treated groups compared to the control...
April 1, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29568964/disruption-of-igf%C3%A2-1r-signaling-by-a-novel-quinazoline-derivative-hmj%C3%A2-30-inhibits-invasiveness-and-reverses-epithelial-mesenchymal-transition-in-osteosarcoma-u%C3%A2-2-os-cells
#20
Yu-Jen Chiu, Mann-Jen Hour, Yi-An Jin, Chi-Cheng Lu, Fuu-Jen Tsai, Tai-Lin Chen, Hsu Ma, Yu-Ning Juan, Jai-Sing Yang
Osteosarcoma is the most common primary malignancy of the bone and is characterized by local invasion and distant metastasis. Over the past 20 years, long-term outcomes have reached a plateau even with aggressive therapy. Overexpression of insulin-like growth factor 1 receptor (IGF‑1R) is associated with tumor proliferation, invasion and migration in osteosarcoma. In the present study, our group developed a novel quinazoline derivative, 6-fluoro‑2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline (HMJ‑30), in order to disrupt IGF‑1R signaling and tumor invasiveness in osteosarcoma U‑2 OS cells...
March 16, 2018: International Journal of Oncology
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