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https://www.readbyqxmd.com/read/29168704/extracellular-polymeric-substance-production-in-high-rate-algal-oxidation-ponds
#1
Taobat A Jimoh, A Keith Cowan
Integrated algal pond systems (IAPSs) combine anaerobic and aerobic bioprocesses to affect sewage treatment. The present work describes the isolation and partial characterisation of soluble extracellular polymeric substances (EPSs) associated with microalgal bacterial flocs (MaB-flocs) generated in high rate algal oxidation ponds (HRAOPs) of an IAPS treating domestic sewage. Productivity and change in MaB-flocs concentration, measured as mixed liquor suspended solids (MLSS) between morning (MLSSAM) and evening (MLSSPM) were monitored and the substructure of the MaB-flocs matrix examined by biochemical analysis and Fourier transform infrared spectroscopy (FT-IR)...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29167839/early-life-exposure-to-indoor-air-pollution-or-tobacco-smoke-and-lower-respiratory-tract-illness-and-wheezing-in-african-infants-a-longitudinal-birth-cohort-study
#2
Aneesa Vanker, Whitney Barnett, Lesley Workman, Polite M Nduru, Peter D Sly, Robert P Gie, Heather J Zar
Background: Indoor air pollution (IAP) and environmental tobacco smoke (ETS) are associated with lower respiratory tract illness (LRTI) or wheezing in children. However, the effect of the timing of these exposures, specifically antenatal versus postnatal, and of alternate fuel sources such as the increasingly used volatile organic compounds have not been well studied. We longitudinally investigated the effect of antenatal or postnatal IAP and ETS on LRTI or wheezing prevalence and severity in African infants...
November 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/29165775/re-operative-abdominal-predictive-score-a-prognostic-model-combining-acute-re-intervention-predictive-index-and-intra-abdominal-pressure
#3
Caridad de Dios Soler-Morejón, Tomás Ariel Lombardo-Vaillant, Teddy Osmín Tamargo-Barbeito, Robert Wise, Manu L N G Malbrain
BACKGROUND: The decision to re-operate after abdominal surgery is still difficult, especially in the setting of intra-abdominal sepsis. Mathematical models provide a good aid to both diagnosis and decision-making. METHODS: A prospective observational study was conducted with 300 patients consecutively admitted to the intensive care unit of an academic institution affiliated to Calixto García Medical Faculty following abdominal surgery from January 2008 to January 2010...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29158846/subcellular-localization-of-survivin-determines-its-function-in-cardiomyocytes
#4
Tien-Jui Tsang, Ying-Chang Hsueh, Erika I Wei, David J Lundy, Bill Cheng, You-Tzung Chen, Shoei-Shen Wang, Patrick C H Hsieh
Rationale: Reducing cardiomyocyte death and enhancing their proliferation after myocardial infarction is perhaps the single largest challenge for cardiac tissue regeneration. Survivin (SVV) is the smallest member of the inhibitor of apoptosis (IAP) family but plays two important roles; inhibiting caspase-9 activation in the intrinsic apoptosis pathway, and regulating microtubule dynamics and chromosome segregation during cell division. Genetic depletion of cardiac SVV leads to incomplete cardiomyocyte division and abnormal heart development...
2017: Theranostics
https://www.readbyqxmd.com/read/29158327/early-onset-group-b-streptococcus-eogbs-infection-subsequent-to-cessation-of-screening-based-intrapartum-prophylaxis-findings-of-an-observational-study-in-west-london-uk
#5
Guduru Gopal Rao, Jane Townsend, Daniel Stevenson, Grace Nartey, Stephen Hiles, Paul Bassett, Theresa Lamagni, Richard Nicholl
OBJECTIVES: To describe the impact on early-onset group B Streptococcus (EOGBS) infection rates following reversion from screening-based to risk-based intrapartum antimicrobial prophylaxis (IAP) for prevention. SETTING: Maternity services provided by secondary healthcare organisation in North West London. PARTICIPANTS: All women who gave birth in the healthcare organisation between April 2016 and March 2017. There were no exclusions. DESIGN: Observational study comparing EOGBS rates in the postscreening period (2016-2017) with prescreening (2009-2013) and screening periods (2014-2015)...
November 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29157092/single-agent-and-synergistic-combinatorial-efficacy-of-first-in-class-small-molecule-imipridone-onc201-in-hematological-malignancies
#6
Varun V Prabhu, Mala K Talekar, Amriti R Lulla, C Leah B Kline, Lanlan Zhou, Junior Hall, A Pieter J Van den Heuvel, David T Dicker, Jawad Babar, Stephan A Grupp, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, Nadia Khan, Wolfgang Oster, Joshua E Allen, Wafik S El-Deiry
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ONC201 demonstrated (GI50 1-8 µM) dose- and time-dependent efficacy in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt's lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma (CTCL), Hodgkin's lymphoma (nodular sclerosis) and multiple myeloma (MM) cell lines including cells resistant to standard of care (dexamethasone in MM) and primary samples...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29152118/sensitization-of-neuroblastoma-for-vincristine-induced-apoptosis-by-smac-mimetic-lcl161-is-attended-by-g2-cell-cycle-arrest-but-is-independent-of-nf%C3%AE%C2%BAb-rip1-and-tnf-%C3%AE
#7
Doerte Langemann, Magdalena Trochimiuk, Birgit Appl, Patrick Hundsdoerfer, Konrad Reinshagen, Georg Eschenburg
We demonstrated sensitization for chemotherapy by Smac mimetic (SM) LCL161, a potent antagonist of inhibitor of apoptosis proteins (IAP), in neuroblastoma (NB). Vinca alkaloids, particularly vincristine (VCR), displayed the strongest impact on inhibition of proliferation and apoptosis induction in combination with LCL161. The underlying signaling pathways remain elusive, though. LCL161 induces a quick degradation of cellular IAP 1 (cIAP-1). Combination of LCL161 with VCR had only marginal effects on X-linked IAP (XIAP) protein expression...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29149051/molecular-alliance-of-lymantria-dispar-multiple-nucleopolyhedrovirus-and-a-short-unmodified-antisense-oligonucleotide-of-its-anti-apoptotic-iap-3-gene-a-novel-approach-for-gypsy-moth-control
#8
Volodymyr V Oberemok, Kateryna V Laikova, Aleksei S Zaitsev, Maksym N Shumskykh, Igor N Kasich, Nikita V Gal'chinsky, Viktoriya V Bekirova, Valentin V Makarov, Alexey A Agranovsky, Vladimir A Gushchin, Ilya V Zubarev, Anatoly V Kubyshkin, Iryna I Fomochkina, Mikhail V Gorlov, Oleksii A Skorokhod
Baculovirus IAP (inhibitor-of-apoptosis) genes originated by capture of host genes. Unmodified short antisense DNA oligonucleotides (oligoDNAs) from baculovirus IAP genes can down-regulate specific gene expression profiles in both baculovirus-free and baculovirus-infected insects. In this study, gypsy moth (Lymantria dispar) larvae infected with multiple nucleopolyhedrovirus (LdMNPV), and LdMNPV-free larvae, were treated with oligoDNA antisense to the RING (really interesting new gene) domain of the LdMNPV IAP-3 gene...
November 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29144242/effects-of-intrapartum-antibiotic-prophylaxis-on-neonatal-acquisition-of-group-b-streptococci
#9
Meiwa Toyofuku, Miyuki Morozumi, Mariko Hida, Yoshitake Satoh, Hiroshi Sakata, Hiroyuki Shiro, Kimiko Ubukata, Mitsuru Murata, Satoshi Iwata
OBJECTIVES: To assess the incidence of colonization with group B streptococci (GBS) among neonates as influenced by maternal GBS carriage and intrapartum antibiotic prophylaxis (IAP). STUDY DESIGN: Between October 2014 and May 2015, nasopharyngeal and rectal swab samples were collected from 730 neonates at 1 week and 1 month after birth. GBS and capsular serotype were identified by real-time polymerase chain reaction and by culture. IAP at delivery was determined retrospectively from hospital records...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29142404/chalepin-a-compound-from-ruta-angustifolia-l-pers-exhibits-cell-cycle-arrest-at-s-phase-suppresses-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-pathway-signal-transducer-and-activation-of-transcription-3-stat3-phosphorylation-and-extrinsic-apoptotic-pathway-in-non-small-cell
#10
Jaime Stella Moses Richardson, Norhaniza Aminudin, Sri Nurestri Abd Malek
Background: Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer. Objective: A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137083/indications-and-outcomes-of-pediatric-keratoplasty-in-a-tertiary-eye-care-center-a-retrospective-review
#11
Rosario Gulias-Cañizo, Roberto Gonzalez-Salinas, Luis Fernando Hernandez-Zimbron, Everardo Hernandez-Quintela, Valeria Sanchez-Huerta
To evaluate indications and outcomes of pediatric keratoplasty in a tertiary eye center, and identify factors that affect visual outcomes.We performed a retrospective review of penetrating keratoplasty in children aged 0 to 18 years between 1995 and 2011 in the Asociación para Evitar la Ceguera en México IAP, Hospital "Dr. Luis Sánchez Bulnes".A total of 574 penetrating keratoplasties were performed during the study interval. Median follow-up was 5.0 years. Main indications included keratoconus (55.58%), postherpetic scarring (9...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135811/the-relationship-between-intra-abdominal-pressure-and-body-acceleration-during-exercise
#12
Johanna Day de Gennaro, Claire K de Gennaro, Janet M Shaw, Tomasz J Petelenz, Ingrid E Nygaard, Robert W Hitchcock
OBJECTIVES: High intra-abdominal pressure (IAP) may influence the development of pelvic floor disorders. We and others have used intravaginal pressure transducers to measure IAP in women during exercise and daily activities, but utilizing the transducer for long-term measurements creates compliance issues. Waist-worn accelerometers are prominent in research and may be a reliable alternative for approximating IAP. We hypothesized that there are pair-wise positive correlations between the mean maximal accelerometer vector magnitude and 2 IAP measurements: mean maximal IAP and area under the curve (AUC)...
November 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29127656/altered-oscillatory-brain-dynamics-of-emotional-processing-in-young-binge-drinkers
#13
Siyuan Huang, Lee A Holcomb, Stephen M Cruz, Ksenija Marinkovic
Heavy episodic drinking, also termed binge drinking, is commonly practiced by young adults. It is accompanied by a range of cognitive, affective, and social problems, but the neural dynamics underlying changes in emotional functions is poorly understood. To investigate the behavioral and brain indices of affective processing as a function of binge drinking, young, healthy participants (23.3 ± 3.3 years) were assigned to two groups (n = 32 each) based on their drinking habits. Binge drinking (BD) participants reported drinking heavily with at least five binge episodes in the last 6 months, whereas light drinkers (LD) reported no more than one binge episode in the last 6 months...
November 10, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29125482/mirna373-induces-cervical-squamous-cell-carcinoma-siha-cell-apoptosis
#14
Zongyu Liu, Limei Fan, He Zhu, Huimei Yu, Fan Yang, Ruiqi Yang, Fei Wu
OBJECTIVE: Cervical squamous cell carcinoma seriously threats to patient's life and health. MiRNAs have role of regulating cell growth, proliferation, and death. MiRNAs can promote or inhibit cell growth and proliferation. This study discussed the role of miRNA373 in regulating cervical squamous cell carcinoma growth, proliferation, and apoptosis. PATIENTS AND METHODS: MiRNA373 and scramble miRNA were synthetized and transfected to cervical squamous cell carcinoma SiHa cells by lipofectamine...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29121604/occupational-exposure-to-indoor-air-pollution-among-bakery-workers-in-ethiopia-a-comparison-of-electric-and-biomass-cookstoves
#15
George S Downward, Hugo P van der Zwaag, Leon Simons, Kees Meliefste, Yifokire Tefera, J Rosales Carreon, Roel Vermeulen, Lidwien A M Smit
The indoor air pollution (IAP) produced by the domestic combustion of solid fuels is responsible for up to 4 million deaths annually, especially among low and middle income countries. Occupational exposure within the food preparation industries of these nations remains underexplored. We investigated occupational exposure to the IAP produced during the commercial production of injera, a staple of the Ethiopian diet, from bakeries in Addis Ababa, Ethiopia. Measurements of PM2.5, black carbon (via the proxy measure PM2...
November 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29117326/infant-group-b-streptococcal-disease-incidence-and-serotypes-worldwide-systematic-review-and-meta-analyses
#16
Lola Madrid, Anna C Seale, Maya Kohli-Lynch, Karen M Edmond, Joy E Lawn, Paul T Heath, Shabir A Madhi, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Margaret Ip, Kirsty Le Doare, Craig E Rubens, Samir K Saha, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Stephanie Schrag
Background: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0-89 days...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117325/risk-of-early-onset-neonatal-group-b-streptococcal-disease-with-maternal-colonization-worldwide-systematic-review-and-meta-analyses
#17
Neal J Russell, Anna C Seale, Catherine O'Sullivan, Kirsty Le Doare, Paul T Heath, Joy E Lawn, Linda Bartlett, Clare Cutland, Michael Gravett, Margaret Ip, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Carol J Baker
Background: Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0-6) born to pregnant women who are rectovaginally colonized with group B Streptococcus (GBS), but the risk of EOGBS from vertical transmission has not been systematically reviewed. This article, the seventh in a series on the burden of GBS disease, aims to estimate this risk and how it varies with coverage of intrapartum antibiotic prophylaxis (IAP), used to reduce the incidence of EOGBS. Methods: We conducted systematic reviews (Pubmed/Medline, Embase, Latin American and Caribbean Health Sciences Literature (LILACS), World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups on maternal GBS colonization and neonatal outcomes...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117324/intrapartum-antibiotic-chemoprophylaxis-policies-for-the-prevention-of-group-b-streptococcal-disease-worldwide-systematic-review
#18
Kirsty Le Doare, Megan O'Driscoll, Kim Turner, Farah Seedat, Neal J Russell, Anna C Seale, Paul T Heath, Joy E Lawn, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Margaret Ip, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Beate Kampmann
Background: Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world. This article is the sixth in a series estimating the burden of GBS disease. Here we aimed to review GBS screening policies and IAP implementation worldwide. Methods: We identified data through (1) systematic literature reviews (PubMed/Medline, Embase, Literature in the Health Sciences in Latin America and the Caribbean [LILACS], World Health Organization library database [WHOLIS], and Scopus) and unpublished data from professional societies and (2) an online survey and searches of policies from medical societies and professionals...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29109763/survivin-and-xiap-expression-in-distinct-tumor-compartments-of-surgically-resected-gastric-cancer-xiap-as-a-prognostic-marker-in-diffuse-and-mixed-type-adenocarcinomas
#19
Levent Dizdar, Monika Tomczak, Thomas A Werner, Sami A Safi, Jasmin C Riemer, Pablo E Verde, Nikolas H Stoecklein, Wolfram T Knoefel, Andreas Krieg
There is considerable evidence that the inhibitor of apoptosis protein (IAP) family serves a role in tumorigenesis. The most studied IAP family members, survivin and X-linked inhibitor of apoptosis (XIAP), have been demonstrated to serve as biomarkers in distinct tumor entities. Thus, the present study aimed to investigate the expression levels of both IAPs in the tumor center, invasion front and lymph node metastases of surgically resected gastric cancer (GC) specimens. Tissue microarrays containing samples from 201 primary GCs were analyzed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108265/cellular-inhibitor-of-apoptosis-protein-2-promotes-the-epithelial-mesenchymal-transition-in-triple-negative-breast-cancer-cells-through-activation-of-the-akt-signaling-pathway
#20
Su Ji Jo, Pil-Gu Park, Hye-Ran Cha, Sung Gwe Ahn, Min Jung Kim, Hyemi Kim, Ja Seung Koo, Joon Jeong, Jeon Han Park, Seung Myung Dong, Jae Myun Lee
Triple-negative breast cancer (TNBC) represents approximately 10-17% of all breast cancers, and patients with TNBC show a poorer short-term prognosis than patients with other types of breast cancer. TNBCs also have a higher tendency for early distant metastasis and cancer recurrence due to induction of the epithelial-mesenchymal transition (EMT). Several recent reports have suggested that inhibitor of apoptosis (IAP) proteins function as regulators of the EMT. However, the roles of these proteins in TNBC are not clear...
October 3, 2017: Oncotarget
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