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P Alex Smith, Yaxin Wang, Shelby A Bieritz, Jeff L Conger, Luiz C Sampaio, William E Cohn, O H Frazier
We are designing an intra-atrial pump (IAP) that will be affixed to the atrial septum and support the compromised left ventricle (LV) in patients with early-stage heart failure without harming the ventricular tissue. It will operate in parallel with the LV, drawing blood from the left atrium and unloading the LV. In previous hydraulic and hemodynamic studies, different blade geometries were tested for the IAP, and the hemodynamic results obtained using a mock circulatory loop showed that the IAP can successfully reduce end-diastolic volume and increase the total systemic flow rate...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
P Alex Smith, Yaxin Wang, Shelby A Bieritz, Luiz C Sampaio, Ralph W Metcalfe, William E Cohn, O H Frazier
An intra-atrial pump (IAP) was proposed that would be affixed to the atrial septum to support the compromised left ventricle (LV) without harming the ventricular tissue in patients with early-stage heart failure. The IAP is designed to operate in parallel with the LV, drawing blood from the left atrium and unloading the LV. In previous hydraulic studies, different blade geometries were tested for the IAP; however, it is important to know how the blade geometry affects the IAP's hemodynamic performance in the human cardiovascular system...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Xiaoya Liu, Shuang Liu, Dongyue Guo, Yue Sheng, Yufeng Ke, Xingwei An, Minpeng Xu, Feng He, Xiaoman Cheng, Dong Ming
In recent years, the interaction between emotion and working memory has been investigated with mixed results. Yet, few neurophysiological studies systematically investigated the effect of emotion states on the updating function of working memory that is a core part of executive functioning. Executive functioning has also been identified as cognitive function, which plays an important role in everyday life and even be a predictor of higher-level cognitive function. Here, we studied the effect of emotions on the updating function of working memory...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Pierluigi Reali, Claudia Cosentini, Paulo de Carvalho, Vicente Traver, Anna M Bianchi
In the last decades numerous researches have revealed a strong link between emotions and several physiological responses. However, the automatic recognition of emotions still remains a challenge. In this work we describe a novel approach to estimate valence, arousal and dominance values from various biological parameters (derived from electrodermal activity, heart rate variability signal and electroencephalography), by means of multiple linear regression models. The models training was performed by using a set of pictures pre-evaluated in terms of valence, arousal and dominance, selected from the International Affective Picture System (IAPS) database...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Kanakaraju Kaliannan, Ruairi C Robertson, Kiera Murphy, Catherine Stanton, Chao Kang, Bin Wang, Lei Hao, Atul K Bhan, Jing X Kang
BACKGROUND: Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS. RESULTS: Here we show that gut microbiome mediates the preventive effect of estrogen (17β-estradiol) on metabolic endotoxemia (ME) and low-grade chronic inflammation (LGCI), the underlying causes of MS and chronic diseases. The characteristic profiles of gut microbiome observed in female and 17β-estradiol-treated male and ovariectomized mice, such as decreased Proteobacteria and lipopolysaccharide biosynthesis, were associated with a lower susceptibility to ME, LGCI, and MS in these animals...
November 13, 2018: Microbiome
Tamalika Paul, Anupam Banerjee, S Vijaya Bhaskara Reddy, Sanjit K Mahato, Nabendu Biswas
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of cytokine superfamily, induces apoptosis in a number of tumor cells through the activation of extrinsic apoptotic pathway but shows little or no cytotoxicity toward normal cells. However some tumor cells are inherently resistant to TRAIL-mediated apoptosis, which needs to be addressed to establish TRAIL as a potential chemotherapeutic drug. In this study, our aim was to manipulate TRAIL-apoptosis pathway by hydroxychavicol (HCH), a polyphenol from Piper betel leaf, for the induction of apoptosis in TRAIL resistant chronic myeloid leukemia cell...
November 8, 2018: Anti-cancer Drugs
Amber Gonda, Janviere Kabagwira, Girish N Senthil, Heather R Ferguson Bennit, Jonathan W Neidigh, Salma Khan, Nathan R Wall
Survivin, a member of the inhibitor of apoptosis (IAP) protein family plays a significant role in cell fate and function. It is significantly overexpressed in tumor cells and has been identified in most cancer cell types. A novel extracellular population has recently been identified and its function is still unknown. Emerging evidence continues to shed light on the important role the tumor microenvironment (TME) has on tumor survival and progression. This new population of survivin has been seen to enhance the tumor phenotype when internalized by recipient cells...
October 9, 2018: Oncotarget
Yukako Okazaki, Tetsuyuki Katayama
We have recently reported that soluble dietary fibre, glucomannan, increased colonic alkaline phosphatase (ALP) activity and the gene expression without affecting the small-intestinal activity and that colonic ALP was correlated with gut mucins (index of intestinal barrier function). We speculated that dietary fermentable carbohydrates including oligosaccharides commonly elevate colonic ALP and gene expression as well as increase mucin secretion and microbial fermentation. To test this hypothesis, male Sprague-Dawley rats were fed a diet containing 30 % lard with or without 4 % fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), raffinose (RAF) and lactulose (LAC), which are non-digestible oligosaccharides or isomalto-oligosaccharides (IMOS; some digestible oligosaccharides) for 2 weeks...
November 7, 2018: British Journal of Nutrition
Dan Li, Jun Liu, Xin Wang, Di Kong, Wei Du, Hongbo Li, Chung-Yun Hse, Todd Shupe, Dongpo Zhou, Kai Zhao
Tripyrrole molecules have received renewed attention due to reports of numerous biological activities, including antifungal, antibacterial, antiprotozoal, antimalarial, immunosuppressive, and anticancer activities. In a screen of bacterial strains with known toxicities to termites, a red pigment-producing strain, HDZK-BYSB107, was isolated from Chamaecyparis lawsoniana , which grows in Oregon, USA. Strain HDZK-BYSB107 was identified as Serratia marcescens subsp. lawsoniana . The red pigment was identified as prodigiosin using ultraviolet absorption, LC-MS, and 1H-NMR spectroscopy...
November 4, 2018: International Journal of Molecular Sciences
Igor Elman, Jaymin Upadhyay, Daniel D Langleben, Mark Albanese, Lino Becerra, David Borsook
In patients with post-traumatic stress disorder (PTSD), a decrease in the brain reward function was reported in behavioral- and in neuroimaging studies. While pathophysiological mechanisms underlying this response are unclear, there are several lines of evidence suggesting over-recruitment of the brain reward regions by aversive stimuli rendering them unavailable to respond to reward-related content. The purpose of this study was to juxtapose brain responses to functional neuroimaging probes that reliably produce rewarding and aversive experiences in PTSD subjects and in healthy controls...
November 2, 2018: Translational Psychiatry
Frank A Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E Kontermann, Frank Allgöwer, Brona M Murphy, Markus Rehm
Due to the lack of effective treatments for glioblastoma (GBM), we here studied the responsiveness of GBM cell lines to the combination of death ligand, TRAIL and the IAP antagonist, TL32711 (Birinapant). Responses were highly heterogeneous, with synergistic apoptosis as well as treatment resistance observed. Caspase-8 and Bid, together with caspase-3, form a nonlinear signalling hub that efficiently induced apoptosis in responder cell lines. Cells resistant to TRAIL/TL32711 expressed low amounts of procaspase-8 and Bid and poorly activated caspase-3...
November 1, 2018: Cell Death & Disease
Amalia Rosner, Olha Kravchenko, Baruch Rinkevich
Inhibitors of Apoptosis Protein (IAP) genes participate in processes like apoptosis, proliferation, innate immunity, inflammation, cell motility, differentiation and in malignancies. Here we reveal 25 IAP genes in the tunicate Botryllus schlosseri's genome and their functions in two developmental biology phenomena, a new mode of whole body regeneration (WBR) induced by budectomy, and blastogenesis, the four-staged cycles of botryllid ascidian astogeny. IAP genes that were specifically upregulated during these developmental phenomena were identified, and protein expression patterns of one of these genes, IAP28, were followed...
October 29, 2018: Developmental Biology
Jie Shi, Bei Gao, Yongyi Yang, Lan Yang, Xiaojuan Li
Objective To investigate the effect of leukodeplated red blood cell (RBC) transfusion on immune function of patients with bladder cancer. Methods A total of 48 patients with bladder cancer who required perioperative RBC transfusion were randomized into two groups: 22 received leukodeplated RBC transfusion (Group I) and 26 received suspended RBC transfusion (Group II ). T-cell subgroup, natural killer cell activity, erythrocyte-C3b receptor rosette formation rate, and immunosuppressive acidic protein (IAP) level were determined for the two groups before and after transfusion, and the results were statistically analyzed...
July 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Vidyadhar V Upasani, Raghav Badrinath, Christine L Farnsworth, Megan E Jeffords, Jericho A Hallare, Syed I Ahmed, Tim Schrader
BACKGROUND: Increased intracapsular hip pressure is thought to be one of the possible etiologies of femoral head avascular necrosis after intra-articular proximal femoral fractures or acute slipped capital femoral epiphysis. The purpose of this study was to evaluate the relationship between intra-articular hip pressure (IAP) and epiphyseal perfusion pressure (EPP), and its dependency on skeletal maturity using a porcine model. METHODS: Seven female Yorkshire-hybrid pigs were used to study the direct relationship between IAP and EPP...
October 29, 2018: Journal of Pediatric Orthopedics
Lalitha Vivekanandan, Hajasherief Sheik, Sengottuvelu Singaravel, Sivakumar Thangavel
Linezolid has a better choice for eradication of methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of linezolid-induced hepatotoxicity, myelosuppression, and lactic acidosis. This research elucidated the role of silymarin against hepatoxicity of linezolid therapy in MRSA infected Wistar rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamide injection. The neutropenic rats were injected subcutaneously with 106 CFU/ml of MRSA. The rats were divided into 6 groups...
October 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nobumichi Ohoka, Osamu Ujikawa, Kenichiro Shimokawa, Tomoya Sameshima, Norihito Shibata, Takayuki Hattori, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
Targeted protein degradation by small molecules is an emerging modality with significant potential for drug discovery. We previously developed chimeric molecules, termed specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs), which induce the ubiquitylation and proteasomal degradation of target proteins. This degradation is mediated by the IAPs; the target proteins include bromodomain-containing protein 4 (BRD4), an epigenetic regulator protein. The SNIPER that degrades this particular protein, SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a bromodomain and extra-terminal (BET) inhibitor, (+)-JQ-1...
October 26, 2018: Chemical & Pharmaceutical Bulletin
Pei-Yao Fu, Bo Hu, Xiao-Lu Ma, Zhang-Fu Yang, Min-Cheng Yu, Hai-Xiang Sun, Ao Huang, Xin Zhang, Jian Wang, Zhi-Qiang Hu, Chen-Hao Zhou, Wei-Guo Tang, Ren Ning, Yang Xu, Jian Zhou
BACKGROUND: Prognosis of hepatocellular carcinoma (HCC) remains poor due to high recurrence rate and ineffective treatment options, highlighting the need to better understand the mechanism of recurrence and metastasis in HCC. METHODS: We first collected messenger RNA (mRNA) expression data from 442 cases of HCC patients from The Cancer Genome Atlas (TCGA) database as well as 251 HCC patients from Zhongshan Hospital during 2009 and 2010 to analyze the expression pattern from tissue microarray (TMA) of baculoviral IAP repeat containing 3 (BIRC3)...
October 28, 2018: Journal of Cellular Biochemistry
Sara Assadiasl, Mohammad Javad Mousavi, Aliakbar Amirzargar
Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal...
2018: Journal of Transplantation
Jennifer Allègre, Jessy Cartier, Valérie Glorian, Nathalie Droin, Baptiste Dumetier, Cémile Kayaci, Jean Berthelet, Simon Gemble, Céline Vuillier, Laurent Maillet, Carmen Garrido, Laurence Dubrez
The cellular inhibitor of apoptosis 1 (cIAP1) is an E3-ubiquitin ligase that regulates cell signaling pathways involved in fundamental cellular processes including cell death, cell proliferation, cell differentiation and inflammation. It recruits ubiquitination substrates thanks to the presence of three baculoviral IAP repeat (BIR) domains at its N-terminal extremity. We previously demonstrated that cIAP1 promoted the ubiquitination of the E2 factor 1 (E2F1) transcription factor. Moreover, we showed that cIAP1 was required for E2F1 stabilization during the S phase of cell cycle and in response to DNA damage...
2018: PloS One
Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W D Armstrong, Pamela J Maxwell, Chee Wee Ong, Melissa J LaBonte, Simon S McDade, David J Waugh, Daniel B Longley
Expression of tumor necrosis factor-α (TNFα) in the serum of prostate cancer patients is associated with poorer outcome and progression to castrate-resistant (CRPC) disease. TNFα promotes the activity of NFκB, which regulates a number of anti-apoptotic and proinflammatory genes, including those encoding the inhibitor of apoptosis proteins (IAPs); however, in the presence of IAP antagonists, TNFα can induce cell death. In the presence of recombinant or macrophage-derived TNFα, we found that IAP antagonists triggered degradation of cIAP1 and induced formation of Complex-IIb, consisting of caspase-8, FADD and RIPK1 in CRPC models; however, no, or modest levels of apoptosis were induced...
October 22, 2018: Cell Death & Disease
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