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https://www.readbyqxmd.com/read/29777353/intestinal-histopathological-changes-in-a-porcine-model-of-pneumoperitoneum-induced-intra-abdominal-hypertension
#1
Ester Párraga Ros, Laura Correa-Martín, Francisco M Sánchez-Margallo, Irma Eugenia Candanosa-Aranda, Manu L N G Malbrain, Robert Wise, Rafael Latorre, Octavio López Albors, Gregorio Castellanos
BACKGROUND: Low splanchnic perfusion is an immediate effect of pneumoperitoneum-induced intra-abdominal hypertension (IAH). Anatomical structure results in the intestinal mucosa being the area most sensitive to hypoperfusion. The relationship between intestinal injury and clinical parameters of tissue perfusion [abdominal perfusion pressure (APP), gastric intramucosal pH (pHi ) and lactic acid (Lc)] has not been previously studied. This study aimed to monitorize intestinal pathogenesis through sequential ileal biopsies and to measure APP, pHi , and Lc levels at different pneumoperitoneum-induced intra-abdominal pressures (20, 30, and 40 mmHg) to evaluate the potential relationships between them...
May 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29772403/theoretical-study-of-the-intermolecular-recognition-mechanism-between-survivin-and-substrate-based-on-conserved-binding-mode-analysis
#2
Chao Wu, Liguang Mao, Xie Huang, Weitao Fu, Xiong Cai, Yuepiao Cai, Liqun Shen, Xiaoxia Ye
Survivin is the smallest member of IAP (inhibitor of apoptosis protein) family, which plays important roles in both mitosis and apoptosis. It has become an attractive drug target due to its overexpression in many human cancers. Survivin has been proven to bind to Smac/DIABLO protein that indirectly inhibits apoptosis. Meanwhile, it is the key subunit of chromosome passenger complex (CPC) which bind to the N-terminal tail of phosphorylated histone H3T3ph during mitosis. Up to now, Survivin directly targeting inhibitor has yet to merge since the difficulty of disrupting the protein-protein interactions (PPIs) between Survivin and its substrate proteins...
May 8, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29769618/inhibitor-of-apoptosis-proteins-iaps-mediate-collagen-type-xi-alpha-1-driven-cisplatin-resistance-in-ovarian-cancer
#3
Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic, Dong-Joo Cheon
Although, cisplatin resistance is a major challenge in the treatment of ovarian cancer, the precise mechanisms underlying cisplatin resistance are not fully understood. Collagen type XI alpha 1 (COL11A1), a gene encoding a minor fibrillar collagen of the extracellular matrix, is identified as one of the most upregulated genes in cisplatin-resistant ovarian cancer and recurrent ovarian cancer. However, the exact functions of COL11A1 in cisplatin resistance are unknown. Here we demonstrate that COL11A1 binds to integrin α1β1 and discoidin domain receptor 2 (DDR2) and activates downstream signaling pathways to inhibit cisplatin-induced apoptosis in ovarian cancer cells...
May 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29760885/areas-of-high-conservation-value-at-risk-by-plant-invaders-in-georgia-under-climate-change
#4
Daniel Slodowicz, Patrice Descombes, David Kikodze, Olivier Broennimann, Heinz Müller-Schärer
Invasive alien plants (IAP) are a threat to biodiversity worldwide. Understanding and anticipating invasions allow for more efficient management. In this regard, predicting potential invasion risks by IAPs is essential to support conservation planning into areas of high conservation value (AHCV) such as sites exhibiting exceptional botanical richness, assemblage of rare, and threatened and/or endemic plant species. Here, we identified AHCV in Georgia, a country showing high plant richness, and assessed the susceptibility of these areas to colonization by IAPs under present and future climatic conditions...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29750801/streptococcus-agalactiae-carriage-among-pregnant-women-living-in-rio-de-janeiro-brazil-over-a-period-of-eight-years
#5
Ana Caroline N Botelho, Juliana G Oliveira, Andreia P Damasco, Késia T B Santos, Ana Flávia M Ferreira, Gabriel T Rocha, Penélope S Marinho, Rita B G Bornia, Tatiana C A Pinto, Marco A Américo, Sergio E L Fracalanzza, Lúcia M Teixeira
Group B Streptococcus (GBS) carriage by pregnant women is the primary risk factor for early-onset GBS neonatal sepsis. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission route, and two main approaches are recommended to base the selection of pregnant women to be submitted to IAP: the risk-based and the culture-based strategies. In Brazil, compliance to such recommendations is poor, and not much is known about GBS carriage. In the present study, 3,647 pregnant women living in Rio de Janeiro State, Brazil, were screened for GBS anogenital colonization, over a period of 8 years (2008-2015)...
2018: PloS One
https://www.readbyqxmd.com/read/29749399/autocrine-tnf-signaling-favors-malignant-cells-in-myelofibrosis-in-a-tnfr2-dependent-fashion
#6
William L Heaton, Anna V Senina, Anthony D Pomicter, Mohamed E Salama, Phillip M Clair, Dongqing Yan, Russell N Bell, Jeremy M Gililland, Josef T Prchal, Thomas O'Hare, Michael W Deininger
Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow (BM) cells expressing TNF is increased in MF compared to controls, with the largest differential in primitive cells. Blockade of TNF receptor 2 (TNFR2), but not TNFR1, selectively inhibited colony formation by MF CD34+ and mouse JAK2V617F progenitor cells. Microarray of mouse MPN revealed reduced expression of X-linked inhibitor of apoptosis (Xiap) and mitogen-activated protein kinase 8 (Mapk8) in JAK2V617F relative to JAK2WT cells, which were normalized by TNFR2 but not TNFR1 blockade...
April 18, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29747111/indoor-air-pollution-affects-hypertension-risk-in-rural-women-in-northern-china-by-interfering-with-the-uptake-of-metal-elements-a-preliminary-cross-sectional-study
#7
Bin Wang, Yibing Zhu, Yiming Pang, Jing Xie, Yongxiu Hao, Huina Yan, Zhiwen Li, Rongwei Ye
Coal combustion and passive smoking are two important contributors to indoor air pollution (IAP) in rural areas of northern China. Although the association between outdoor air pollutants and hypertension risk had been widely reported, fewer studies have examined the relationship between IAP and hypertension risk. This study evaluated the association between IAP and hypertension risk in housewives in rural areas of northern China and the potential mediation pathway of metal elements. Our cross-sectional study, conducted in Shanxi Province, China, enrolled 367 subjects without taking anti-hypertensive drugs, including 142 subjects with hypertension (case group) and 225 subjects without hypertension (control group)...
May 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29744296/plasma-anti-birc5-igg-may-be-a-useful-marker-for-evaluating-the-prognosis-of-nonsmall-cell-lung-cancer
#8
Huan Zhao, Xuan Zhang, Zhifeng Han, Zhenqi Wang, Yao Wang
A recent study demonstrated that circulating levels of IgG antibodies against linear peptide antigens derived from baculoviral IAP repeat-containing protein 5 isoform 2 (BIRC5) and myc proto-oncogene protein (MYC) were significantly increased in nonsmall cell lung cancer (NSCLC). This study was undertaken to replicate this initial work in an independent sample. An enzyme-linked immunosorbent assay (ELISA) was developed in-house to examine plasma IgG antibodies for three linear peptide antigens derived from BIRC5a, BIRC5b, and MYC in 211 patients with NSCLC and 200 control subjects...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29743550/inhibitor-of-apoptosis-proteins-are-required-for-effective-fusion-of-autophagosomes-with-lysosomes
#9
Sylwia Gradzka, Oliver S Thomas, Oliver Kretz, Aladin Haimovici, Lazaros Vasilikos, Wendy Wei-Lynn Wong, Georg Häcker, Ian E Gentle
Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's disease. Crohn's disease is also caused by mutations in the gene encoding NOD2 but the mechanisms behind Crohn's disease development in XIAP and NOD2 deficient-patients are still unknown. Numerous other mutations causing Crohn's Disease occur in genes controlling various aspects of autophagy, suggesting a strong involvement of autophagy in preventing Crohn's disease...
May 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29741974/the-effect-of-different-intraabdominal-pressures-on-thiol-disulfide-homeostasis-in-children-who-underwent-ambulatory-laparoscopic-surgery-a-prospective-randomized-study
#10
Seyda Efsun Ozgunay, Yasemin Ustundag, Derya Karasu, Ilken Uguz, Ozcan Erel, Gulsen Korfali, Mete Kaya
BACKGROUND: Thiol/disulfide homeostasis is a significant parameter in determining the oxidative stress response after ischemia and reperfusion. We aimed to investigate the effects of applying different intraabdominal pressure (IAP) on thiol/disulfide homeostasis, ischemia-modified albumin (IMA) levels, and hemodynamics in pediatric laparoscopic surgery. MATERIALS AND METHODS: Blood samples were collected from 36 pediatric patients who were planned to undergo laparoscopic surgery for nonpalpable testis or varicocele under general anesthesia, immediately after intubation as the baseline and 5 minutes after abdominal desufflation for determining the thiol/disulfide, and IMA levels...
May 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29741767/down-regulation-of-intracellular-anti-apoptotic-proteins-particularly-c-flip-by-therapeutic-agents-the-novel-view-to-overcome-resistance-to-trail
#11
REVIEW
Ali Hassanzadeh, Majid Farshdousti Hagh, Mohammad Reza Alivand, Ali Akbar Movassaghpour Akbari, Karim Shams Asenjan, Raedeh Saraei, Saeed Solali
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a member of the tumor necrosis factor (TNF) superfamily that induces apoptosis in different types of cancer cells via activation of caspase cascade. TRAIL interacts with its cognate receptors that placed on cancer cells surface, including TRAIL-R1 (death receptor 4, DR4), TRAIL-R2 (death receptor 5, DR5), TRAIL-R3 (decoy receptor 1, DcR1), TRAIL-R4 (decoy receptor 2, DcR2), and osteoprotegerin (OPG). Despite high apoptosis-inducing ability of TRAIL, various cancerous cells gain resistance to TRAIL gradually, and consequently TRAIL potential for apoptosis stimulation in these cells diminishes intensely...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29740716/increase-in-intra-abdominal-pressure-during-airway-suctioning-induced-cough-after-a-successful-spontaneous-breathing-trial-is-associated-with-extubation-outcome
#12
Yasuhiro Norisue, Jun Kataoka, Yosuke Homma, Takaki Naito, Junpei Tsukuda, Kentaro Okamoto, Takeshi Kawaguchi, Lonny Ashworth, Shimada Yumiko, Yuiko Hoshina, Eiji Hiraoka, Shigeki Fujitani
BACKGROUND: A patient's ability to clear secretions and protect the airway with an effective cough is an important part of the pre-extubation evaluation. An increase in intra-abdominal pressure (IAP) is important in generating the flow rate necessary for a cough. This study investigated whether an increase from baseline in IAP during a coughing episode induced by routine pre-extubation airway suctioning is associated with extubation outcome after a successful spontaneous breathing trial (SBT)...
May 8, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29735611/survivin-inhibitors-mitigate-chemotherapeutic-resistance-in-breast-cancer-cells-by-suppressing-genotoxic-nf-kappab-activation
#13
Wei Wang, Bo Zhang, Arul M Mani, Zhongzhi Wu, Yu Fan, Wei Li, Zhao-Hui Wu
Therapeutic resistance developed after chemotherapy and aggressive metastasis are the major causes for cancer-related death in triple negative breast cancer (TNBC) patients. Survivin is the smallest member of Inhibitor-of-Apoptosis Proteins (IAPs) family, which plays critical roles in cell division and cell survival. High expression levels of survivin have been associated with therapeutic resistance in various cancers. We recently developed a novel small molecule survivin inhibitor mimicking IAP-binding motif of second mitochondria-derived activator of caspase, which showed high potency in promoting survivin degradation...
May 7, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29729000/the-effect-of-sadness-on-global-local-processing
#14
Adrian von Mühlenen, Lauren Bellaera, Amrendra Singh, Narayanan Srinivasan
Gable and Harmon-Jones (Psychological Science, 21(2), 211-215, 2010) reported that sadness broadens attention in a global-local letter task. This finding provided the key test for their motivational intensity account, which states that the level of spatial processing is not determined by emotional valence, but by motivational intensity. However, their finding is at odds with several other studies, showing no effect, or even a narrowing effect of sadness on attention. This paper reports two attempts to replicate the broadening effect of sadness on attention...
May 4, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29728652/defective-germline-reprogramming-rewires-the-spermatogonial-transcriptome
#15
Lina Vasiliauskaitė, Rebecca V Berrens, Ivayla Ivanova, Claudia Carrieri, Wolf Reik, Anton J Enright, Dónal O'Carroll
Defective germline reprogramming in Piwil4 (Miwi2)- and Dnmt3l-deficient mice results in the failure to reestablish transposon silencing, meiotic arrest and progressive loss of spermatogonia. Here we sought to understand the molecular basis for this spermatogonial dysfunction. Through a combination of imaging, conditional genetics and transcriptome analysis, we demonstrate that germ cell elimination in the respective mutants arises as a result of defective de novo genome methylation during reprogramming rather than because of a function for the respective factors within spermatogonia...
May 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29723880/factors-known-to-influence-the-development-of-necrotizing-enterocolitis-to-modify-expression-and-activity-of-intestinal-alkaline-phosphatase-in-a-newborn-neonatal-rat-model
#16
Rebecca Maria Rentea, Matthea J Rentea, Ben Biesterveld, Jennifer L Liedel, David M Gourlay
INTRODUCTION:  Prematurity, formula feeding, and early weaning strongly influence enterocyte differentiation. Intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, is one enzyme that is affected by these factors. IAP supplementation decreases the severity of necrotizing enterocolitis (NEC) injury. We, therefore, hypothesized that prematurity predisposes this population to NEC due to IAP deficiency and investigated IAP expression and function in a neonatal rat model...
May 3, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29721043/trim32-promotes-proliferation-and-confers-chemoresistance-to-breast-cancer-cells-through-activation-of-the-nf-%C3%AE%C2%BAb-pathway
#17
Ting-Ting Zhao, Feng Jin, Ji-Guang Li, Ying-Ying Xu, Hui-Ting Dong, Qun Liu, Peng Xing, Guo-Lian Zhu, Hao Xu, Song-Cheng Yin, Zhi-Feng Miao
Dysregulation of TRIM32 has been implicated in several human cancers, however, its clinical significance and biological function in breast cancer have not been investigated. Using immunohistochemistry, we found that TRIM32 expression is upregulated in breast cancer tissues and that it correlates with advanced stage and poor prognosis. TRIM32 is also overexpressed in 4/7 breast cancer cell lines. CCK8 and colony formation assays showed that TRIM32 depletion inhibited proliferation and colony formation in the T47D cell line, while TRIM32 overexpression promoted MCF-7 cell growth and colony formation...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29721013/changes-in-hepatic-blood-flow-and-liver-function-during-closed-abdominal-hyperthermic-intraperitoneal-chemotherapy-following-cytoreduction-surgery
#18
Stéphanie Dupont, Eduardo R C Schiffer, Marion J White, John R A Diaper, Marc-Joseph Licker, Philippe C Masouyé
Background: The increase in intra-abdominal pressure (IAP) during closed abdominal hyperthermic intraperitoneal chemotherapy (HIPEC) leads to major haemodynamic changes and potential organ dysfunction. We investigated these effects on hepatic blood flow (HBF) and liver function in patients undergoing HIPEC following cytoreductive surgery and fluid management guided by dynamic preload indices. Methods: In this prospective observational clinical study including 15 consecutive patients, we evaluated HBF by transesophageal echocardiography and liver function by determination of the indocyanine green plasma disappearance rate (ICG-PDR)...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29715494/prime-visibility-moderates-implicit-anger-and-sadness-effects-on-effort-related-cardiac-response
#19
David Framorando, Guido H E Gendolla
Based on the Implicit-Affect-Primes-Effort (IAPE) model (Gendolla, 2012, 2015), an experiment investigated the effect of affect primes' visibility on effort mobilization during cognitive processing. Participants worked on a short-term memory task with integrated sadness vs. anger primes that were presented suboptimally (briefly and masked) vs. optimally (long and visible). Effort was assessed as cardiovascular response, especially cardiac pre-ejection period (PEP). To monitor performance, we assessed response accuracy and reaction times...
April 28, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29714759/isolated-attosecond-pulse-in-the-water-window-from-many-cycle-laser-driven-plasma-mirrors-without-pulse-engineering
#20
Zi-Yu Chen
High-order harmonic generation from relativistic laser-driven plasma mirrors is an attractive route to produce highly energetic attosecond pulses in the extreme ultraviolet to x-ray regime. To achieve an isolated attosecond pulse (IAP) driven by many-cycle intense laser pulses, pulse engineering techniques such as polarization modulation and wavefront rotation, are usually needed. Here we show that it is possible to generate an IAP without pulse engineering. Through particle-in-cell simulations, it is found that plasma mirrors can be rapidly heated and deformed in a relatively long preplasma regime...
May 1, 2018: Optics Letters
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