keyword
MENU ▼
Read by QxMD icon Read
search

IAP

keyword
https://www.readbyqxmd.com/read/28436480/dihydromyricetin-induces-apoptosis-and-reverses-drug-resistance-in-ovarian-cancer-cells-by-p53-mediated-downregulation-of-survivin
#1
Yingqi Xu, Shengpeng Wang, Hon Fai Chan, Huaiwu Lu, Zhongqiu Lin, Chengwei He, Meiwan Chen
Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industry and medicine for a long time. However, little is known about the effects of DHM on ovarian cancer and the underlying mechanisms. In this study, we demonstrated that DHM could effectively inhibit the proliferation of ovarian cancer cells and induce cell apoptosis...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431398/decreased-calpain-activity-in-chronic-myeloid-leukemia-impairs-apoptosis-by-increasing-survivin-in-myeloid-progenitors-and-xiap1-in-differentiating-granulocytes
#2
Weiqi Huang, Ling Bei, Elizabeth E Hjort, Elizabeth A Eklund
Chronic Myeloid Leukemia (CML) is characterized by translocations between chromosomes 9 and 22, resulting in expression of Bcr-abl oncogenes. Although the clinical course of CML was revolutionized by development of Bcr-abl-directed tyrosine kinase inhibitors (TKIs), CML is not cured by these agents. Specifically, the majority of subjects relapsed in clinical trials attempting TKI discontinuation, suggesting persistence of leukemia stem cells (LSCs) even in molecular remission. Identifying mechanisms of CML-LSC persistence may suggest rationale therapeutic targets to augment TKI efficacy and lead to cure...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429109/associations-of-maximal-voluntary-isometric-hip-extension-torque-with-muscle-size-of-hamstring-and-gluteus-maximus-and-intra-abdominal-pressure
#3
Kota Tayashiki, Kosuke Hirata, Kiraku Ishida, Hiroaki Kanehisa, Naokazu Miyamoto
PURPOSE: Muscle size of the hamstring and gluteus maximus (GM) as well as intra-abdominal pressure (IAP) are considered as factors affecting the torque development during hip extension. This study examined the associations of torque development during maximal voluntary isometric hip extension with IAP and muscle size of the hamstring and GM. METHODS: Anatomical cross-sectional area (ACSA) of the hamstring and thickness of GM were determined in 20 healthy young males using an ultrasonography apparatus (Experiment 1)...
April 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28429087/the-abdoman-an-artificial-abdominal-wall-simulator-for-biomechanical-studies-on-laparotomy-closure-techniques
#4
L F Kroese, J J Harlaar, C Ordrenneau, J Verhelst, G Guérin, F Turquier, R H M Goossens, G-J Kleinrensink, J Jeekel, J F Lange
PURPOSE: Incisional hernia remains a frequent complication after abdominal surgery associated with significant morbidity and high costs. Animal and clinical studies have exhibited some limitations. The purpose of this study was to develop an artificial human abdominal wall (AW) simulator in order to enable investigations on closure modalities. We hypothesized that a physical model of the human AW would give new insight into commonly used suture techniques representing a substantial complement or alternative to clinical and animal studies...
April 20, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28428059/the-decreased-growth-performance-and-impaired-immune-function-and-structural-integrity-by-dietary-iron-deficiency-or-excess-are-associated-with-tor-nf-%C3%AE%C2%BAb-p38mapk-nrf2-and-mlck-signaling-in-head-kidney-spleen-and-skin-of-grass-carp-ctenopharyngodon-idella
#5
Yan-Lin Guo, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Qiu Zhou, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
This study was conducted to investigate the effects of dietary iron on the growth, and immune function and structural integrity in head kidney, spleen and skin as well as the underlying signaling of young grass carp (Ctenopharyngodon idella). Total 630 grass carp (242.32 ± 0.58 g) were fed diets containing graded levels of iron at 12.15 (basal diet), 35.38, 63.47, 86.43, 111.09, 136.37 mg/kg (diets 2-6 were added with ferrous fumarate) and 73.50 mg/kg (diet 7 was added with ferrous sulfate) diet for 60 days...
April 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28425584/changes-in-ciap2-survivin-and-bimel-expression-characterize-the-switch-from-autophagy-to-apoptosis-in-prolonged-starvation
#6
A Hay-Koren, S Bialik, V Levin-Salomon, A Kimchi
BACKGROUND: Autophagy is a catabolic process involving the engulfment of cytoplasmic content within autophagosomes followed by their delivery to lysosomes. This process is a survival mechanism, enabling cells to cope with nutrient deprivation by degradation and recycling of macromolecules. Yet during continued stress such as prolonged starvation, a switch from autophagy to apoptosis is often detected. OBJECTIVE: In this work, we characterized the temporal dynamics of the transition from autophagy towards apoptosis with the aim of elucidating the molecular mechanism regulating the switch from survival autophagy to apoptotic cell death...
May 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28424988/overcoming-chemotherapy-drug-resistance-by-targeting-inhibitors-of-apoptosis-proteins-iaps
#7
REVIEW
Rama Rathore, Jennifer E McCallum, Elizabeth Varghese, Ana-Maria Florea, Dietrich Büsselberg
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within tissue but also to fight disease or infection. Uninhibited, IAPs can suppress apoptosis and promote cell cycle progression. Therefore, it is unsurprising that cancer cells demonstrate significantly elevated expression levels of IAPs, resulting in improved cell survival, enhanced tumor growth and subsequent metastasis. Therapies to target IAPs in cancer has garnered substantial scientific interest and as resistance to anti-cancer agents becomes more prevalent, targeting IAPs has become an increasingly attractive strategy to re-sensitize cancer cells to chemotherapies, antibody based-therapies and TRAIL therapy...
April 19, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28424943/intestinal-alkaline-phosphatase-attenuates-alcohol-induced-hepatosteatosis-in-mice
#8
Sulaiman R Hamarneh, Byeong-Moo Kim, Kanakaraju Kaliannan, Sara A Morrison, Tyler J Tantillo, Qingsong Tao, Mussa M Rafat Mohamed, Juan M Ramirez, Aaron Karas, Wei Liu, Dong Hu, Abeba Teshager, Sarah Shireen Gul, Konstantinos P Economopoulos, Atul K Bhan, Madhu S Malo, Michael Y Choi, Richard A Hodin
BACKGROUND AND AIMS: Bacterially derived factors from the gut play a major role in the activation of inflammatory pathways in the liver and in the pathogenesis of alcoholic liver disease. The intestinal brush-border enzyme intestinal alkaline phosphatase (IAP) detoxifies a variety of bacterial pro-inflammatory factors and also functions to preserve gut barrier function. The aim of this study was to investigate whether oral IAP supplementation could protect against alcohol-induced liver disease...
April 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28418937/clinical-validation-of-a-new-wrist-continuous-noninvasive-hemodynamic-monitoring-system-in-comparison-with-invasive-radial-artery-measurement
#9
Chen Li, Chanjuan Li, Wei Zhang, Ling Wang, Zhidong Wang, Yongji Wang, Jielai Xia
BACKGROUND: An ideal arterial pressure monitoring system for perioperative care is required to be accurate, noninvasive, continuous, and risk free. Although several continuous noninvasive arterial pressures (CNAP) are determined on the finger, a new wrist CNAP monitoring system was developed. This prospective study was designed as a randomized-controlled trial to assess its validity in comparison with invasive arterial pressure (IAP) monitoring. PATIENTS AND METHODS: Sixty patients undergoing elective surgery under general anesthesia were enrolled...
April 17, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28410461/gradients-of-fear-how-perception-influences-fear-generalization
#10
Dieter Struyf, Jonas Zaman, Dirk Hermans, Bram Vervliet
The current experiment investigated whether overgeneralization of fear could be due to an inability to perceptually discriminate the initial fear-evoking stimulus from similar stimuli, as fear learning-induced perceptual impairments have been reported but their influence on generalization gradients remain to be elucidated. Three hundred and sixty-eight healthy volunteers participated in a differential fear conditioning paradigm with circles of different sizes as conditioned stimuli (CS), of which one was paired to an aversive IAPS picture...
June 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28400412/western-diet-consumption-induces-alteration-of-barrier-function-mechanisms-in-the-ileum-that-correlates-with-metabolic-endotoxemia-in-rats
#11
Mathilde Guerville, Anaïs Leroy, Annaëlle Sinquin, Fabienne Laugerette, Marie-Caroline Michalski, Gaëlle Boudry
Obesity and its related disorders have been associated to the presence in the blood of gut bacteria-derived lipopolysaccharides (LPS). However, the factors underlying this low-grade elevation in plasma LPS, so-called metabolic endotoxemia, are not fully elucidated. We aimed to investigate the effects of Western diet (WD) feeding on intestinal and hepatic LPS handling mechanisms in a rat model of diet-induced obesity (DIO). Rats were fed either a standard chow diet (C) or a Western Diet (WD, 45% fat) for 6 weeks...
April 11, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28393441/intestinal-alkaline-phosphatase-at-the-crossroad-of-intestinal-health-and-disease-a-putative-role-in-type-1-diabetes
#12
M I Lassenius, C L Fogarty, M Blaut, K Haimila, L Riittinen, A Paju, J Kirveskari, J Järvelä, A J Ahola, D Gordin, M-A Härma, A Kumar, S R Hamarneh, R A Hodin, T Sorsa, T Tervahartiala, S Hörkkö, P J Pussinen, C Forsblom, M Jauhiainen, M-R Taskinen, P-H Groop, M Lehto
BACKGROUND: Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in response to high-fat meals. Intestinal alkaline phosphatase (IAP) regulates lipid transport and inflammatory responses in the gastrointestinal tract. We therefore hypothesized that changes in IAP activity could have profound effects on gut metabolic homeostasis in patients with type 1 diabetes. METHODS: Faecal samples of 41 nondiabetic controls and 46 patients with type 1 diabetes were analysed for IAP activity, calprotectin, immunoglobulins and short-chain fatty acids (SCFAs)...
April 10, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28384094/nuclear-survivin-promoted-by-acetylation-is-associated-with-the-aggressive-phenotype-of-oral-squamous-cell-carcinoma
#13
Shuli Liu, Lei Shi, Xi Yang, Dongxia Ye, Tong Wang, Cunshan Dong, Wenzheng Guo, Yueling Liao, Hongyong Song, Dongliang Xu, Jingzhou Hu, Zhiyuan Zhang, Jiong Deng
Defects in apoptotic pathway contribute to development and progression of oral cancer. Survivin, a member of the inhibitors of apoptosis protein (IAP) family, is increased in many types of cancers. However, it is unclear whether increased survivin is associated with oral squamous cell carcinomas (OSCC), and what mechanisms may involve in. In this study, we examined survivin expression in OSCC compared with normal oral tissues via immunohistochemical staining. The results showed that, not only total survivin is increased in OSCCs, but also the subcellular location of survivin is changed in OSCCs compared with normal oral tissues...
April 6, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28382010/bizarreness-and-emotion-identification-in-grete-stern-photomontages-gender-and-age-disparities
#14
Alejandra Rosales-Lagarde, Claudia Isabel Martínez-Alcalá, Patricia Pliego-Pastrana, Eva María Molina-Trinidad, José-Luis Díaz
Although the International Affective Picture System (IAPS) is used to evaluate emotions (valence, arousal, and dominance evoked by a large set of photographs), bizarre images in works of art have not been assessed with the IAPS procedures. Understood here as strange, non-sense, and absurd mental contents or expressions accompanied by surprise and confusion emotions, bizarreness was assessed after healthy adult volunteers assigned this specified variable to 140 Grete Stern's photomontages overtly intended to illustrate strange, absurd, and non-sensical contents in dream reports...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28372994/neural-activation-during-cognitive-reappraisal-in-girls-at-high-risk-for-depression
#15
F Simsek, K Oguz, O Kitis, S T Akan, M J Kempton, A S Gonul
OBJECTIVE: Although emotion dysregulation, one of the core features of depression, has long been thought to be a vulnerability factor for major depressive disorder (MDD), surprisingly few functional magnetic resonance imaging (fMRI) studies have investigated neural correlates of emotion regulation strategies in unaffected high risk individuals. METHOD: Sixteen high risk (RSK) young women and fifteen matched low risk controls (CTL) were scanned using fMRI while performing an emotion regulation task...
March 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28372417/study-of-hydrogen-ecr-plasma-in-a-simple-mirror-magnetic-trap-heated-by-75-ghz-pulsed-gyrotron-radiation
#16
V A Skalyga, I V Izotov, A V Sidorov, S V Golubev, S V Razin
Plasma of electron cyclotron resonance (ECR) discharge sustained by millimeter wave radiation is widely used for production of ion beams of different kind. The main trend in ECR ion sources development nowadays is an increase of frequency and power of microwave heating. The most advanced systems use gyrotrons in 24-60 GHz frequency range. In previous studies at IAP RAS it was demonstrated that ECR source SMIS 37 (Simple Mirror Ion Source) with 37.5 GHz heating operating in quasigasdynamic regime of plasma confinement is able to produce proton and deuteron beams with ion current density about 700 mA/cm(2)...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28368273/consensus-statement-of-the-indian-academy-of-pediatrics-on-evaluation-and-management-of-learning-disability
#17
M K C Nair, Chhaya Prasad, Jeeson Unni, Anjan Bhattacharya, S S Kamath, Samir Dalwai
JUSTIFICATION: Learning Disability (LD) in children is a well-recognized developmental disorder, which has profound academic and psychosocial consequences. Due to the complex nature of LD and multiple disadvantages posed to the child due to LD, a multidisciplinary approach towards intervention is warranted. Given the paucity of evidence-based standardized treatment approaches, consensus guidelines for management of LD are needed. PROCESS: The meeting on formulation of national consensus guidelines on neurodevelopmental disorders was organized by Indian Academy of Pediatrics in Mumbai, on 18th and 19th December, 2015...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28368272/consensus-statement-of-the-indian-academy-of-pediatrics-on-evaluation-and-management-of-autism-spectrum-disorder
#18
Samir Dalwai, Shabina Ahmed, Vrajesh Udani, Nandini Mundkur, S S Kamath, M K C Nair
JUSTIFICATION: Autism Spectrum Disorder (ASD) is a clinically heterogenous condition with a wide range of etiological factors and causing significant public health burden. ASD poses a serious developmental disadvantage to the child in the form of poor schooling, social function and adult productivity. Thus, framing evidence-based national guidelines is a pressing need. PROCESS: The meeting on formulation of national consensus guidelines on neurodevelopmental disorders was organized by Indian Academy of Paediatrics in Mumbai on 18th and 19th December 2015...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28368271/consensus-statement-of-the-indian-academy-of-pediatrics-on-evaluation-and-management-of-attention-deficit-hyperactivity-disorder
#19
Samir Dalwai, Jeeson Unni, Veena Kalra, Pratibha Singhi, Leena Shrivastava, M K C Nair
JUSTIFICATION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly prevalent in children worldwide. Management of ADHD requires a systematic, multidisciplinary approach and thereby, evidence-based, standardized national guidelines are essential. PROCESS: A meeting for formulation of national consensus guidelines on neurodevelopmental disorders was organized by Indian Academy of Pediatrics in Mumbai, on 18th and 19th December, 2015. The invited experts included Pediatricians, Developmental Pediatricians, Pediatric Neurologists, Psychiatrists, Remedial Educators and Clinical Psychologists...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28361787/iap-guidelines-on-rickettsial-diseases-in-children
#20
Narendra Rathi, Atul Kulkarni, Vijay Yewale
OBJECTIVE: To formulate practice guidelines on rickettsial diseases in children for pediatricians across India. JUSTIFICATION: Rickettsial diseases are increasingly being reported from various parts of India. Due to low index of suspicion, nonspecific clinical features in early course of disease, and absence of easily available, sensitive and specific diagnostic tests, these infections are difficult to diagnose. With timely diagnosis, therapy is easy, affordable and often successful...
March 15, 2017: Indian Pediatrics
keyword
keyword
109182
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"