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Kuo Sun, Qi Liao, Zenggan Chen, Tongyi Chen, Jian Zhang
Baculoviral IAP repeat containing 7 (BIRC7/Livin/ML-IAP/KIAP; referred to as Livin throughout the present study) and placental growth factor (PlGF) are not detectable in the majority of normal differentiated tissues, but are present in a number of types of cancer, including hepatocellular carcinoma, ovarian cancer and renal cell carcinoma. The aim of the present study was to assess the expression levels of Livin and PlGF in human osteosarcoma specimens and cell lines, and to analyze the functions of Livin and PIGF in the prognosis of osteosarcoma...
October 2018: Oncology Letters
Jia Cao, Jing Qiu, Xi Wang, ZhenHui Lu, Danni Wang, HuiMin Feng, XiaoHan Li, QiaoQiao Liu, HuaZheng Pan, XueBo Han, Jun Wei, ShiHai Liu, LiBin Wang
MicroRNAs (miRNAs) being proved to be involved in the carcinogenesis of numerous tumors. MicroRNA-124 (miR-124), identified as a tumor suppressor, has been demonstrated to exert pivotal roles in multiple processes of tumorigenesis. The present study demonstrated that miR-124 was low-expressed in human hepatocellular carcinoma (HCC) tissues and cell lines. In addition, overexpression of miR-124 through infected with miR-124 lentivirus inhibited the proliferation and migration of HCC in vitro and tumorigenesis in vivo , whereas inhibition of miR-124 expression can reverse the process...
2018: Journal of Cancer
Asha Tyagi, Shubham Lahan, Gaurav Verma, Shukla Das, Mahendra Kumar
Aims: This prospective cohort study evaluated intra-abdominal pressure (IAP) and its role in causing acute kidney injury (AKI) in critically ill obstetric patients and utility of urinary neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI. Methods: A total of 50 eligible obstetric patients admitted to our Intensive Care Unit were enrolled and daily IAP measured using indwelling Foley catheter. Early AKI was diagnosed as per the KDIGO criteria and urine assessed for NGAL using ELISA...
August 2018: Indian Journal of Critical Care Medicine
G G Denisov, M Yu Glyavin, A P Fokin, A N Kuftin, A I Tsvetkov, A S Sedov, E A Soluyanova, M I Bakulin, E V Sokolov, E M Tai, M V Morozkin, M D Proyavin, V E Zapevalov
A 250 GHz continuous-wave (CW) gyrotron has been developed at the IAP RAS jointly with GYCOM Ltd., as a prototype of the microwave source for the envisaged prospective nuclear fusion power plants (DEMO). The main applications of such a tube are electron cyclotron resonance heating and electron cyclotron resonance current drive of magnetically confined plasma as well as its diagnostics based on collective Thomson scattering in various reactors for controlled thermonuclear fusion (e.g., tokamaks and stellarators)...
August 2018: Review of Scientific Instruments
Soudabeh Vatankhah, Rahim Ali Sheikhi, Mohammad Heidari, Parisa Moradimajd
Background: Excessive fluid administration for saving patients from hypovolemic shocks is one of the main causes of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). The purpose of this paper is to survey the relationship between fluid resuscitation and increase intra-abdominal pressure (IAP). Materials and Methods: The present descriptive-analytical study recruited 100 patients with confirmed abdominal trauma and presenting to emergency departments...
July 2018: International Journal of Critical Illness and Injury Science
Jens Brøndum Frøkjær, Fatih Akisik, Ammad Farooq, Burcu Akpinar, Anil Dasyam, Asbjørn Mohr Drewes, Ingfrid S Haldorsen, Giovanni Morana, John P Neoptolemos, Søren Schou Olesen, Maria Chiara Petrone, Andrea Sheel, Tooru Shimosoegawa, David C Whitcomb
The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT) is often the most appropriate initial imaging modality for evaluation of patients with suspected chronic pancreatitis (CP) depicting most changes in pancreatic morphology. CT is also indicated to exclude other potential intraabdominal pathologies presenting with symptoms similar to CP. However, CT cannot exclude a diagnosis of CP nor can it be used to exclusively diagnose early or mild disease...
August 28, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Nobumichi Ohoka
 Protein knockdown technologies based on small molecules are attracting considerable attention in the pharmaceutical industry as a strategy for novel drug discovery. We and others have developed such compounds, designated as Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs), proteolysis-targeting chimeras (PROTACs), and Degronimids, which induce selective degradation of target proteins. These compounds contain two different ligands, specific for an ubiquitin E3 ligase and for a target protein, respectively, connected by a linker...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Chang-Ming Bai, Umberto Rosani, Lu-Sheng Xin, Gui-Yang Li, Chen Li, Qing-Chen Wang, Chong-Ming Wang
The ark shell, Scapharca (Anadara) broughtonii, is an economically important marine shellfish species in Northwestern Pacific. Mass mortalities of ark shell adults related to Ostreid herpesvirus-1 (OsHV-1) infection have occurred frequently since 2012. However, due to the lack of transcriptomic resource of ark shells, the molecular mechanisms underpinning the virus-host interaction remains largely undetermined. In the present study, we resolved the dual transcriptome changes of OsHV-1 infected ark shell with Illumina sequencing...
August 27, 2018: Fish & Shellfish Immunology
Alper Bitkin, Mustafa Aydin, Lokman Irkilata, Mevlut Keles, Ebubekir Akgunes, Sonmez Ocak, Mustafa Kemal Atilla
OBJECTIVE: To determine the potential utility of hematological parameters in the diagnosis of intra-abdominal hypertension (IAH). STUDY DESIGN: Cross-sectional descriptive study. PLACE AND DURATION OF STUDY: Health Sciences University, Samsun Training and Research Hospital, Samsun, Turkey, from January 2016 to July 2017. METHODOLOGY: Forty-two patients who underwent transperitoneal laparoscopic urologic surgery were included...
September 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Esmaeil Salimi, Bao Le-Vinh, Forouhe Zahir-Jouzdani, Barbara Matuszczak, Azadeh Ghaee, Andreas Bernkop-Schnürch
To overcome the mucus layer and cell membrane barrier, self-emulsifying drug delivery systems (SEDDS) exhibiting negative zeta potential, switching to positive values when having reached the cell membrane is a promising approach. Accordingly, a novel conjugate was synthesized by covalent attachment of phosphotyrosine to octadecylamine, which was incorporated into SEDDS. Generated system presented an average diameter of 32 nm and zeta potential of around -12 mV when being diluted 1:100 in 100 mM HEPES buffer pH 7...
August 24, 2018: International Journal of Pharmaceutics
Jen-Fu Hsu, Chyi-Liang Chen, Chien-Chung Lee, Reyin Lien, Shih-Ming Chu, Ren-Huei Fu, Ming-Chou Chiang, Chang-Yo Yang, Mei-Yin Lai, I-Hsyuan Wu, Yu-Shan Yen, Cheng-Hsun Chiu
BACKGROUND: Group B streptococcus (GBS) infections can be life-threatening in newborns. This study aimed to analyze GBS carriage status and genotypic diversity in healthy neonates after implementation of intrapartum antibiotic prophylaxis (IAP) in Taiwan. METHODS: Newborns carrying GBS were identified from a screen of 500 newborns and followed up until their cultures turned negative. Their mothers' GBS screening data were reviewed. Molecular methods, including capsular serotyping, multilocus sequence typing and pulsed-field gel electrophoresis (PFGE), were used to analyze GBS isolates...
August 2, 2018: Pediatrics and Neonatology
Stephanie Hehlgans, Patrick Booms, Ömer Güllülü, Robert Sader, Claus Rödel, Panagiotis Balermpas, Franz Rödel, Shahram Ghanaati
Vismodegib, an inhibitor of the Hedgehog signaling pathway, is an approved drug for monotherapy in locally advanced or metastatic basal cell carcinoma (BCC). Data on combined modality treatment by vismodegib and radiation therapy, however, are rare. In the present study, we examined the radiation sensitizing effects of vismodegib by analyzing viability, cell cycle distribution, cell death, DNA damage repair and clonogenic survival in three-dimensional cultures of a BCC and a head and neck squamous cell carcinoma (HNSCC) cell line...
August 23, 2018: International Journal of Molecular Sciences
Lin Zheng, Wei-Dan Jiang, Lin Feng, Pei Wu, Ling Tang, Sheng-Yao Kuang, Yun-Yun Zeng, Xiao-Qiu Zhou, Yang Liu
This study focused on the effects of dietary selenium deficiency on structural integrity of the head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella). A total of 540 healthy grass carp (mean weight 226.48 ± 0.68 g) were randomly divided into six groups and fed six separate diets with graded dietary levels of selenium (0.025-1.049 mg/kg diet) for 80 days. Results showed that selenium deficiency (1) caused oxidative damage in part by reducing the activities of antioxidant enzymes (such as SOD, CAT, GPx, GST and GR) and glutathione (GSH) content, down-regulating the transcript abundances of antioxidant enzymes (except GSTp1) partly related to Kelch-like-ECH-associated protein 1a (Keap1a)/NF-E2-related factor 2 (Nrf2) signalling; (2) aggravated apoptosis in part by up-regulating the mRNA levels of caspase-2, -3, -7, -8 and -9, which were partially related to p38MAPK/FasL/caspase-8 signalling and JNK/(BAX, Bcl-2, Mcl-1b, IAP)/(Apaf1, caspase-9) signalling; (3) damaged the tight junctions in part by down-regulating the mRNA levels of ZO-1 (except spleen), ZO-2 (except spleen), claudin-c, -f, -7, -11 and claudin-15, and up-regulating the mRNA levels of claudin-12, which were partially related to myosin light chain kinase (MLCK) signalling...
August 22, 2018: Fish & Shellfish Immunology
Shuo-Peng Wei, Wei-Dan Jiang, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Feng
Grass carp (223.85-757.33 g) were fed diets supplemented with magnesium (73.54-1054.53 mg/kg) for 60 days to explore the impacts of magnesium deficiency on the growth and intestinal structural integrity of the fish. The results demonstrated that magnesium deficiency suppressed the growth and damaged the intestinal structural integrity of the fish. We first demonstrated that magnesium is partly involved in (1) attenuating antioxidant ability by suppressing Nrf2 signalling to decrease antioxidant enzyme mRNA levels and activities (except CuZnSOD mRNA levels and activities); (2) aggravating apoptosis by activating JNK (not p38MAPK) signalling to upregulate proapoptotic protein (Apaf-1, Bax and FasL) and caspase-2, -3, -7, -8 and -9 gene expression but downregulate antiapoptotic protein (Bcl-2, IAP and Mcl-1b) gene expression; (3) weakening the function of tight junctional complexes (TJs) by promoting myosin light chain kinase (MLCK) signalling to downregulate TJ gene expression [except claudin-7, ZO-2b and claudin-15 gene expression]...
August 23, 2018: Scientific Reports
Le Bai, Karen Bernard, Xuebo Tang, Min Hu, Jeffrey C Horowitz, Victor J Thannickal, Yan Y Sanders
Fibrotic responses involve multiple cellular processes, including epigenetic changes. Epigenetic changes are sensitive to alterations in the tissue microenvironment such as the flux of tricarboxylic acid (TCA) cycle metabolites. TCA metabolites directly regulate epigenetic states, in part, by regulating histone modification related enzymes. Glutaminolysis is a critical metabolic process by which glutamine is converted to glutamate by glutaminase then to α-ketoglutarate (α-KG), a TCA cycle metabolite. Idiopathic pulmonary fibrosis (IPF) is a disease characterized by aberrant metabolism, including enhanced glutaminolysis...
August 21, 2018: American Journal of Respiratory Cell and Molecular Biology
Yanfeng Li, Wenbo Gao, Yan Ma, Guanyu Zhu, Fuhui Chen, Hongyan Qu
Gastric cancer can be a fatal tumor and therefore represents one of the primary challenges in modern oncology. Survivin and X-linked inhibitor of apoptosis protein (XIAP) are members of the IAP family, which exerts a strong inhibitory effect on cellular apoptosis. In previous studies, the expression levels of survivin and XIAP have been demonstrated to influence the prognosis of patients with gastric cancer; therefore, the present study investigated the effect of silencing survivin and XIAP on the biological activity of the gastric cancer HGC-27 cell line...
September 2018: Oncology Letters
Xiaobin Shang, Guoyan Liu, Yuefeng Zhang, Peng Tang, Hongdian Zhang, Hongjing Jiang, Zhentao Yu
As a mitotic spindle checkpoint gene, baculoviral IAP repeat containing 5 (BIRC5) serves pivotal roles in the development of various types of malignant tumors. In the present study, the expression of BIRC5 in patients with different stages of esophageal squamous cell cancer (ESCC) was investigated. The effect of BIRC5 on the migratory and invasive abilities of different ESCC cell lines was analyzed. Additionally, the effect of BIRC5 on the angiogenesis-associated factor vascular endothelial growth factor, brain-specific angiogenesis inhibitor 1 and methyl-CpG binding domain protein 2 was examined...
September 2018: Oncology Letters
Melek Parlak Khalily, Selin Gerekçi, Ezgi A Güleç, Can Özen, Salih Özçubukçu
The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activity. Although the seven N-terminal amino acids AVPIAQK (SmacN7) of Smac protein is able to elicit an anticancer response by itself, it is neither cell-permeable nor stable in the cellular environment...
August 19, 2018: Amino Acids
Achmet Ali, Taner Abdullah, Pulat Akin Sabanci, Lerzan Dogan, Mukadder Orhan-Sungur, Ibrahim Ozkan Akinci
We aimed to compare the ability of pulse pressure variation (PPV) to predict fluid responsiveness in prone and supine positions and investigate effect of body mass index (BMI), intraabdominal pressure (IAP) and static respiratory compliance (CS) on PPV. A total of 88 patients undergoing neurosurgery were included. After standardized anesthesia induction, patients' PPV, stroke volume index (SVI), CS and IAP values were recorded in supine (T1) and prone (T2) positions and after fluid loading (T3). Also, PPV change percentage (PPVΔ% ) between T2 and T1 times was calculated...
August 16, 2018: Journal of Clinical Monitoring and Computing
Shawn T Beug, Stephanie J Pichette, Martine St-Jean, Janelle Holbrook, Danielle E Walker, Eric C LaCasse, Robert G Korneluk
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize with the attenuated oncolytic vesicular stomatitis virus (VSVΔ51) by eliciting an innate immune response, which is dependent on the endogenous production of TNF-α and type I interferon. To improve on this SMC-mediated synergistic response, we generated TNF-α-armed VSVΔ51 to produce elevated levels of this death ligand...
September 28, 2018: Molecular Therapy Oncolytics
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