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https://www.readbyqxmd.com/read/28529715/inducing-death-in-tumor-cells-roles-of-the-inhibitor-of-apoptosis-proteins
#1
REVIEW
Darren Finlay, Peter Teriete, Mitchell Vamos, Nicholas D P Cosford, Kristiina Vuori
The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death. Indeed, cancer cells regularly acquire resistance to programmed cell death, or apoptosis, which not only supports cancer progression but also leads to resistance to therapeutic agents. Thus, various approaches have been undertaken in order to induce apoptosis in tumor cells for therapeutic purposes. Here, we will focus our discussion on agents that directly affect the apoptotic machinery itself rather than on drugs that induce apoptosis in tumor cells indirectly, such as by DNA damage or kinase dependency inhibition...
2017: F1000Research
https://www.readbyqxmd.com/read/28528977/imatinib-induces-autophagy-via-upregulating-xiap-in-gist882%C3%A2-cells
#2
Qingqing Xie, Qi Lin, Dezhi Li, Jianming Chen
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms originating from the gastrointestinal tract with gain of function mutations in receptor tyrosine kinases KIT or platelet-derived growth factor receptor A (PDGFRA). The main effective treatment for GISTs is tyrosine kinase inhibitors, such as imatinib mesylate. However, GISTs respond to imatinib treatment eventually develop acquired resistance, which is a main obstacle for GISTs therapy. Therefore, it's urgent to have a better understanding of the mechanisms underlying the imatinib resistance in GISTs to develop novel therapeutic strategies...
May 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28526931/reduced-amygdala-reactivity-and-impaired-working-memory-during-dissociation-in-borderline-personality-disorder
#3
Annegret Krause-Utz, Dorina Winter, Friederike Schriner, Chui-De Chiu, Stefanie Lis, Philip Spinhoven, Martin Bohus, Christian Schmahl, Bernet M Elzinga
Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the context of a working memory task in BPD. We aimed to investigate whole-brain activity and amygdala functional connectivity (FC) during an Emotional Working Memory Task (EWMT) after dissociation induction in un-medicated BPD patients compared to healthy controls (HC)...
May 19, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28523228/resting-state-and-personality-component-bis-bas-predict-the-brain-activity-eeg-and-fnirs-measure-in-response-to-emotional-cues
#4
Michela Balconi, Maria E Vanutelli, Elisabetta Grippa
INTRODUCTION: The present study explored the role of resting state and personality component (BIS/BAS measure) on prefrontal cortical responsiveness to emotional cues. Indeed, we supposed that lateralized resting activity (right vs. left) and approach (BAS) versus avoidance (BIS) attitude may explain the successive emotional processing within the prefrontal cortex (PFC) based on the stimulus valence (positive and negative emotional cues). METHODS: Hemodynamic (functional near-infrared spectroscopy, fNIRS) and electroencephalographic (EEG) measures were considered...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28523094/modulation-of-the-inhibitors-of-apoptosis-proteins-iaps-activities-for-cancer-treatment
#5
EDITORIAL
Ahmed F Abdel-Magid
No abstract text is available yet for this article.
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28520795/birc6-mediates-imatinib-resistance-independently-of-mcl-1
#6
Denis O Okumu, Michael P East, Merlin Levine, Laura E Herring, Raymond Zhang, Thomas S K Gilbert, David W Litchfield, Yanping Zhang, Lee M Graves
Baculoviral IAP repeat containing 6 (BIRC6) is a member of the inhibitors of apoptosis proteins (IAPs), a family of functionally and structurally related proteins that inhibit apoptosis. BIRC6 has been implicated in drug resistance in several different human cancers, however mechanisms regulating BIRC6 have not been extensively explored. Our phosphoproteomic analysis of an imatinib-resistant chronic myelogenous leukemia (CML) cell line (MYL-R) identified increased amounts of a BIRC6 peptide phosphorylated at S480, S482, and S486 compared to imatinib-sensitive CML cells (MYL)...
2017: PloS One
https://www.readbyqxmd.com/read/28513822/abdominal-pressure-and-gastrointestinal-function-an-inseparable-couple
#7
Annika Reintam Blaser, Manu Lng Malbrain, Adrian Regli
Evaluating the degree of organ dysfunction is a cornerstone in distinguishing patients with critical illness from those without. However, evaluation of the gastrointestinal (GI) function in critically ill patients is not unified, and is still largely based on subjective clinical evaluation. Intra-abdominal pressure (IAP) has been proposed as a parameter to facilitate monitoring of abdominal compartment in critical illness, but the interactions between IAP and GI function are poorly clarified.The aim of this current review is to describe interactions and associations between GI dysfunction and IAP from a pathophysiological and clinical point of view...
May 17, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28509321/evaluation-of-tissue-metalloproteinase-inhibitor-timp-1-and-survivin-levels-during-third-trimester-pregnancy-a-preliminary-report
#8
Agata Karowicz-Bilińska, Urszula Kowalska-Koprek, Dorota Estemberg, Anita Sikora-Szubert
OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis proteins family (IAP), that suppresses caspase activation, influences VEGF expression and promotes proliferative action of endothelial cells. MATERIAL AND METHODS: The aim of the study was to assess concentrations of two independent anti-apoptotic factors...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28506430/george-e-palade-memorial-lecture-my-life-in-pancreatic-research-unexpected-results-may-open-the-door
#9
REVIEW
Makoto Otsuki
The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. It is a great honor to be awarded the 2016 Palade Prize. While I was in graduate school, I was conducting research on hypothalamo-pituitary-thyroid axis; after finishing graduate school, I began research on amylase isoenzymes. This was the first step of my pancreatic research...
May 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28502073/early-impact-of-abdominal-compartment-syndrome-on-liver-kidney-and-lung-damage-in-a-rodent-model
#10
Ricardo Lima, Pedro L Silva, Vera L Capelozzi, Mariana G Oliveira, Maria Cristina E Santana, Fernanda F Cruz, Paolo Pelosi, Alberto Schanaider, Manu L N G Malbrain, Patricia R M Rocco
BACKGROUND: Abdominal compartment syndrome (ACS) sometimes occurs in critically ill patients following damage control surgery. The purpose of the present study was to develop a model of ACS and to evaluate its pathologic impact on liver, kidney, and lung morphology. METHODS: Twenty Wistar rats (mass 300-350 g) were randomly divided into four groups: 1) intra-abdominal hypertension (IAH): a laparotomy was performed and the abdomen packed with cotton until an intra-abdominal pressure (IAP) of 15 mm Hg was reached; 2) hypovolemia (HYPO): blood was withdrawn until a mean arterial pressure ~60 mm Hg was reached; 3) IAH + HYPO (to resemble clinical ACS); and 4) sham surgery...
May 14, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28502072/the-effects-of-nursing-activities-on-the-intra-abdominal-pressure-of-patients-at-risk-for-intra-abdominal-hypertension
#11
Rosemary K Lee
BACKGROUND: Intra-abdominal hypertension (IAH) occurs frequently in critically ill patients, and adds to their morbidity and mortality. There is no published evidence on the effects of nursing activities on the intra-abdominal pressure (IAP) for patients at risk of IAH. The purpose of this study was to identify the effects of hygiene care on the IAP of patients at risk for IAH. METHODS: Hygiene care was provided to 34 at-risk patients. IAP was measured prior to initiating the hygiene care, immediately after and 10 minutes later...
May 14, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28499495/distraction-suppression-and-distress-endurance-diminish-the-extent-to-which-generalized-conditioned-fear-is-associated-with-maladaptive-behavioral-avoidance
#12
Christopher Hunt, Samuel E Cooper, Melissa P Hartnell, Shmuel Lissek
A central conditioning correlate of clinical anxiety is the over-generalization of Pavlovian fear to safe stimuli resembling conditioned danger cues (CS+). Though much of the pathogenic influence of such generalization may lie in the unnecessary behavioral avoidance it evokes, few studies have examined maladaptive avoidance associated with Pavlovian generalization. Lab-based assessments of this process, here referred to as instrumental avoidance from Pavlovian generalization (IAP-G), have recently begun. The current study represents a next step in this line of work by examining personality factors that may reduce maladaptive IAP-G...
April 27, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28492317/discovery-of-a-potent-non-peptidomimetic-small-molecule-antagonist-of-cellular-inhibitor-of-apoptosis-protein-1-ciap1-and-x-linked-inhibitor-of-apoptosis-protein-xiap
#13
Emiliano Tamanini, Ildiko Maria Buck, Gianni Chessari, Elisabetta Chiarparin, James E H Day, Martyn Frederickson, Charlotte M Griffiths-Jones, Keisha Hearn, Tom D Heightman, Aman Iqbal, Christopher Norbert Johnson, Edward J Lewis, Vanessa Martins, Torren Peakman, Michael Reader, Sharna J Rich, George A Ward, Pamela A Williams, Nicola E Wilsher
XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways. Overexpression of IAPs occurs in various cancers and has been associated with tumor progression and resistance to treatment. Structure-based drug design (SBDD) guided by structural information from X-ray crystallography, computational studies and NMR solution conformational analysis was successfully applied to a fragment-derived lead resulting in AT-IAP, a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 and a structurally novel chemical probe for IAP biology...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28490247/effects-of-valent-image-based-secondary-tasks-on-verbal-working-memory
#14
Phillip L Morgan, Craig Williams, Fay M Ings, Nia C Hughes
Two experiments examined if exposure to emotionally valent image-based secondary tasks introduced at different points of a free recall working memory (WM) task impair memory performance. Images from the International Affective Picture System (IAPS: Lang, Bradley, & Cuthbert, 2008) varied in the degree of negative or positive valance (mild, moderate, strong) and were positioned at low, moderate, and high WM load points with participants rating them based upon perceived valence. As predicted, and based on previous research and theory, the higher the degree of negative (Experiment 1) and positive (Experiment 2) valence and the higher the WM load when a secondary task was introduced, the greater the impairment to recall...
May 11, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28475174/diverse-ubiquitin-linkages-regulate-rip-kinases-mediated-inflammatory-and-cell-death-signaling
#15
REVIEW
Axel Witt, Domagoj Vucic
Members of the RIP kinase family are key regulators of inflammation and cell death signaling implicated in maintaining immune responses and proper tissue homeostasis. Increasing evidence points to post-translational modifications of RIP1, RIP2 and RIP3 as being critical for regulating their function. Ubiquitination and the E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, that direct substrate selectivity as well as the deubiquitinating enzymes, such as A20 and OTULIN, that reverse these modifications dictate the outcome of RIP kinase signaling...
May 5, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28473260/isolation-and-characterization-of-listeria-monocytogenes-from-the-black-headed-gull-feces-in-kunming-china
#16
Xiaolong Cao, Yi Wang, Yan Wang, Changyun Ye
Listeria monocytogenes is among the most important foodborne pathogens, which can be isolated from bird feces. The aim of this study was to examine the prevalence, genotypes, virulence factors and drug-resistance characteristics of L. monocytogenes isolated from the black-headed gull in Kunming, China. Serotypes and virulence genes were identified by polymerase chain reaction. Pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) methods were used to describe the genetic characteristics of all positive isolates...
May 1, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28462521/ripk3-in-cell-death-and-inflammation-the-good-the-bad-and-the-ugly
#17
REVIEW
Susana Orozco, Andrew Oberst
Necroptosis is a form of cell death that can be observed downstream of death receptor or pattern recognition receptor signaling under certain cellular contexts, or in response to some viral and bacterial infections. The receptor interacting protein kinases-1 (RIPK1) and RIPK3 are at the core of necroptotic signaling, among other proteins. Because this pathway is normally halted by the pro-apoptotic protease caspase-8 and the IAP ubiquitin ligases, how and when necroptosis is triggered in physiological settings are ongoing questions...
May 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28460231/heart-rate-variability-changes-and-emotion-regulation-abilities-in-short-and-long-term-abstinent-alcoholic-individuals
#18
Caroline Claisse, Olivier Cottencin, Laurent Ott, Guillaume Berna, Thierry Danel, Jean-Louis Nandrino
INTRODUCTION: Difficulties in identifying and regulating emotion are recognized as major factors of relapse in alcohol use disorders (AUD). This study aimed to evaluate the differences of emotion regulation processes in AUD patients with short-term (STA, less than one month) and long-term abstinence (LTA, at least six months) by recording the high frequency of Heart Rate Variability (HF-HRV) in response to emotional and neutral stimuli. METHOD: Emotional induction constituted the presentation of highly emotional and neutral pictures (IAPS data base) presenting human interactions...
April 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28453927/tir-domain-containing-adapter-inducing-interferon-%C3%AE-trif-forms-filamentous-structures-whose-pro-apoptotic-signalling-is-terminated-by-autophagy
#19
I E Gentle, K T McHenry, A Weber, A Metz, O Kretz, D Porter, G Häcker
The formation of amyloid-like protein structures has recently emerged as a feature in signal transduction, particularly in innate immunity. These structures appear to depend on defined domains for their formation but likely also require dedicated ways to terminate signalling. We here define the innate immunity protein/Toll-like receptor adaptor TRIF as a novel platform of fibril formation and probe signal initiation through TRIF as well as its termination in toll-like receptor 3 (TLR3)-stimulated melanoma cells...
April 28, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28453118/-community-center-for-human-development-program-for-african-colombian-families-based-on-the-participatory-action-research-approach
#20
Yenny M Barreto-Zorza, Vilma F Velasquez-Gutierrez
Objective: To describe the process of construction of a program of Primary Health Care (PHC) for African-Colombian families in Guapi, Cauca. Methodology: Participatory action research (PAR). Results: The PHC program is a collective construction between the IAP Group and the Commission for Support and Follow-up (CAS), carried out in four phases: 1. Field preparation; 2. Approximation to the universe of the African-Colombian families of Guapi; 3...
September 2016: Revista de Salud Pública
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