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https://www.readbyqxmd.com/read/28213189/is-heart-rate-variability-hrv-an-adequate-tool-for-evaluating-human-emotions-a-focus-on-the-use-of-the-international-affective-picture-system-iaps
#1
Kwang-Ho Choi, Junbeom Kim, O Sang Kwon, Min Ji Kim, Yeon Hee Ryu, Ji-Eun Park
Because human emotion varies greatly among individuals and is a qualitative factor, measuring it with any degree of accuracy is very difficult. Heart rate variability (HRV), which is used in evaluations of the autonomic nervous system (ANS), is used to evaluate human emotions. This study examines the validity of HRV as a tool to evaluate emotions using the International Affective Picture System (IAPS). For experimentation, five photos were selected for each of the categories of "happy," "unhappy", and "neutral" from among the images provided by the IAPS...
February 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28206783/initial-validation-of-the-self-directed-violence-picture-system-sdvps
#2
Sarra Nazem, Jeri E Forster, Lisa A Brenner
A better understanding of factors that differentiate those who only experience suicidal ideation from those who engage in self-directed violence (SDV) is critical for suicide prevention efforts (Klonsky & May, 2014; May & Klonsky, 2016). To identify who is at greatest risk for death by suicide, it is imperative that new innovative assessment tools be created to facilitate behavioral measurement of key constructs associated with increased risk for SDV. The aim of the current study was to develop and validate a set of suicide-specific images, called the Self-Directed Violence Picture System (SDVPS), to help meet this need...
February 16, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28204973/iaps-and-cell-death
#3
John Silke, James Vince
IAPs were named as inhibitors of apoptosis, programmed cell death, but it has become apparent that they are regulators of other types of cell death too. Because they inhibit cell death in cancer cells there has been an intense interest in developing inhibitors of these proteins to induce or sensitise cancer cells to death. In this article, we will discuss the involvement of IAPs in the apoptosis, necroptosis and pyroptosis programmed cell death paradigms. All these types of cell death are intimately involved with causing or repressing inflammation and it should perhaps therefore come as no surprise that IAPs are also involved in regulating inflammation directly...
February 16, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28204927/bicortical-facet-screws-as-a-new-option-for-posterior-c2-fixation-anatomical-study-and-clinical-experience
#4
Angelo Rusconi, E Freitas-Olim, P Coloma, R Messerer, C Barrey
PURPOSE: C2 fixation is a demanding procedure, particularly in patients with variants of C1-C2 anatomy. The inferior articular process (IAP) of the axis can be an alternative for screw placement. We report the results of a CT study of C2 IAP anatomy and we present the clinical experience of 28 patients operated with this technique. METHODS: Anatomical study: 50 CT angiographies of the vertebral arteries (VA) were used for this study and, therefore, 100 IAPs were considered...
February 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28198370/smac-mimetics-synergize-with-immune-checkpoint-inhibitors-to-promote-tumour-immunity-against-glioblastoma
#5
Shawn T Beug, Caroline E Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L Senger, Stephen M Robbins, Peter Staeheli, Peter A Forsyth, Tommy Alain, Eric C LaCasse, Robert G Korneluk
Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innate immune stimulants and immune checkpoint inhibitor biologics to produce durable cures in mouse models of glioblastoma in which single agent therapy is ineffective. The complementation of activities between these classes of therapeutics is dependent on cytotoxic T-cell activity and is associated with a reduction in immunosuppressive T-cells...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28192613/sniper-tacc3-induces-cytoplasmic-vacuolization-and-sensitizes-cancer-cells-to-bortezomib
#6
Nobumichi Ohoka, Katsunori Nagai, Norihito Shibata, Takayuki Hattori, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
We previously developed a hybrid small molecule SNIPER (Specific and Nongenetic IAP-dependent Protein ERaser) against transforming acidic coiled-coil-3 (TACC3), SNIPER(TACC3), that induces proteasomal degradation of TACC3 protein. In this study, we found that SNIPER(TACC3) induces cytoplasmic vacuolization derived from endoplasmic reticulum (ER) and paraptosis-like cell death selectively in cancer cells. Mechanistic analysis suggests that accumulation of ubiquitylated protein aggregates that requires X-linked inhibitor of apoptosis protein (XIAP) induces ER stress, which results in ER-stress responses involving X-box binding protein-1 (XBP-1) and ER-derived vacuolization in cancer cells...
February 13, 2017: Cancer Science
https://www.readbyqxmd.com/read/28186371/gene-expression-and-epigenetic-aberrations-in-f1-placentas-fathered-by-obese-males
#7
Megan Mitchell, Reiner Strick, Pamela L Strissel, Ralf Dittrich, Nicole O McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Gene expression and/or epigenetic deregulation may have consequences for sperm and blastocysts, as well as for the placenta, together potentially contributing to problems observed in offspring. We previously demonstrated specific perturbations of fertilization, blastocyst formation, implantation, as well as aberrant glucose metabolism and adiposity in offspring using a mouse model of paternal obesity. The current investigation analysed gene expression and methylation of specific CpG residues in F1 placentas of pregnancies fathered by obese and normal-weight male mice, using real-time PCR and bisulfite pyrosequencing...
February 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28176915/downregulation-of-dcr3-sensitizes-hepatocellular-carcinoma-cells-to-trail-induced-apoptosis
#8
Chaojie Liang, Yingchen Xu, Guangming Li, Tuanjie Zhao, Feng Xia, Guanqun Li, Dongxin Zhang, Jixiang Wu
Decoy receptor 3 (DcR3) has been recently described as an antiapoptosis and prometastasis factor since it can competitively bind to FasL, TL1A, and LIGHT, and it is highly expressed in many malignant tumors. Downregulation of DcR3 can promote tumor cell apoptosis and inhibit metastasis. A previous study demonstrated that reduction of DcR3 could induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in pancreatic cancer cells. However, whether such an effect is seen in hepatocellular carcinoma (HCC) remains to be explored...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28171727/multiplexed-phosphoproteomic-profiling-using-titanium-dioxide-and-immuno-affinity-enrichments-reveals-complementary-phosphorylation-events
#9
Anthony P Possemato, Joao A Paulo, Daniel Mulhern, Ailan Guo, Steven P Gygi, Sean A Beausoleil
A comprehensive view of protein phosphorylation remains an unmet challenge in the field of cell biology. Mass spectrometry-based proteomics is one of the most promising approaches for identifying thousands of phosphorylation events in a single experiment, yet the full breadth of the phosphoproteome has yet to be elucidated. In this report, we examined the complementarity of two methods for phosphopeptide enrichment based on either titanium dioxide (TiO2) enrichment or phosphorylation motif-specific immuno-affinity precipitation (IAP) with four different antibodies...
February 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28168035/evaluating-the-responses-of-forest-ecosystems-to-climate-change-and-co2-using-dynamic-global-vegetation-models
#10
Xiang Song, Xiaodong Zeng
The climate has important influences on the distribution and structure of forest ecosystems, which may lead to vital feedback to climate change. However, much of the existing work focuses on the changes in carbon fluxes or water cycles due to climate change and/or atmospheric CO 2, and few studies have considered how and to what extent climate change and CO 2 influence the ecosystem structure (e.g., fractional coverage change) and the changes in the responses of ecosystems with different characteristics. In this work, two dynamic global vegetation models (DGVMs): IAP-DGVM coupled with CLM3 and CLM4-CNDV, were used to investigate the response of the forest ecosystem structure to changes in climate (temperature and precipitation) and CO 2 concentration...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28160777/curcumin-decreases-malignant-characteristics-of-glioblastoma-stem-cells-via-induction-of-reactive-oxygen-species
#11
Zachary C Gersey, Gregor A Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M Walters, Kelechi C Ohaeto, Ricardo J Komotar, Regina M Graham
BACKGROUND: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12-14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation of treatment-resistant cancer stem cells. Current research has revealed curcumin, the principal ingredient in turmeric, can modulate multiple signaling pathways important for cancer stem cell self-renewal and survival...
February 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28154167/in-vivo-knockdown-of-pathogenic-proteins-via-specific-and-nongenetic-iap-dependent-protein-erasers-snipers
#12
Nobumichi Ohoka, Keiichiro Okuhira, Masahiro Ito, Katsunori Nagai, Norihito Shibata, Takayuki Hattori, Osamu Ujikawa, Kenichiro Shimokawa, Osamu Sano, Ryokichi Koyama, Hisashi Fujita, Mika Teratani, Hirokazu Matsumoto, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
Many diseases, especially cancers, result from aberrant or over-expression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but are limited mainly to enzymes. An alternative approach that may have utility in drug development relies on selective degradation of pathogenic proteins via small, chimeric molecules linking an E3 ubiquitin ligase to the targeted protein for proteasomal degradation. To this end, we recently developed a protein-knockdown system based on hybrid small-molecule SNIPERs (Specific and Nongenetic IAP-dependent Protein Erasers) that recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins...
February 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28149532/bivalent-iap-antagonists-but-not-monovalent-iap-antagonists-inhibit-tnf-mediated-nf-%C3%AE%C2%BAb-signaling-by-degrading-traf2-associated-ciap1-in-cancer-cells
#13
Y Mitsuuchi, C A Benetatos, Y Deng, T Haimowitz, S C Beck, M R Arnone, G S Kapoor, M E Seipel, S K Chunduru, M A McKinlay, C G Begley, S M Condon
The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines results in induction of cell death. A variety of IAP antagonist compounds targeting the baculovirus IAP protein repeat 3 (BIR3) domain of cIAP1have advanced into clinical trials. Here we sought to compare and contrast the biochemical activities of selected monovalent and bivalent IAP antagonists with the intent of identifying functional differences between these two classes of IAP antagonist drug candidates...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28143460/chlorella-sorokiniana-induces-mitochondrial-mediated-apoptosis-in-human-non-small-cell-lung-cancer-cells-and-inhibits-xenograft-tumor-growth-in-vivo
#14
Ping-Yi Lin, Ching-Tsan Tsai, Wan-Ling Chuang, Ya-Hsuan Chao, I-Horng Pan, Yu-Kuo Chen, Chi-Chen Lin, Bing-Yen Wang
BACKGROUND: Lung cancer is one of the leading causes of cancer related deaths worldwide. Marine microalgae are a source of biologically active compounds and are widely consumed as a nutritional supplement in East Asian countries. It has been reported that Chlorella or Chlorella extracts have various beneficial pharmacological compounds that modulate immune responses; however, no studies have investigated the anti-cancer effects of Chlorella sorokiniana (CS) on non-small cell lung cancer (NSCLC)...
February 1, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28139737/histone-h4-expression-is-cooperatively-maintained-by-ikk%C3%AE-and-akt1-which-attenuates-cisplatin-induced-apoptosis-through-the-dna-pk-rip1-iaps-signaling-cascade
#15
Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wang
While chromatin remodeling mediated by post-translational modification of histone is extensively studied in carcinogenesis and cancer cell's response to chemotherapy and radiotherapy, little is known about the role of histone expression in chemoresistance. Here we report a novel chemoresistance mechanism involving histone H4 expression. Extended from our previous studies showing that concurrent blockage of the NF-κB and Akt signaling pathways sensitizes lung cancer cells to cisplatin-induced apoptosis, we for the first time found that knockdown of Akt1 and the NF-κB-activating kinase IKKβ cooperatively downregulated histone H4 expression, which increased cisplatin-induced apoptosis in lung cancer cells...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28139689/nf-%C3%AE%C2%BAb-suppresses-apoptosis-and-promotes-bladder-cancer-cell-proliferation-by-upregulating-survivin-expression-in-vitro-and-in-vivo
#16
Xiaolu Cui, Dezhi Shen, Chuize Kong, Zhe Zhang, Yu Zeng, Xuyong Lin, Xiankui Liu
Nuclear factor kappa-B (NF-κB) activation is a common phenomenon in cancers, which results in the aberrant expression of NF-κB target genes and leads to malignant transformation, metastatic dissemination, abnormal cell proliferation or resistance to cell death. Survivin is a unique member of the IAP family, a well-known cancer-specific molecule and a molecular marker of poor clinical outcome in several cancer types, including bladder cancer. YM-155, a potent survivin suppressor, has been shown to have anti-tumor activity in preclinical cell lines, xenograft models and phase I/II studies...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115634/roles-of-miwi-mili-and-pld6-in-small-rna-regulation-in-mouse-growing-oocytes
#17
Yuka Kabayama, Hidehiro Toh, Ami Katanaya, Takayuki Sakurai, Shinichiro Chuma, Satomi Kuramochi-Miyagawa, Yumiko Saga, Toru Nakano, Hiroyuki Sasaki
The mouse PIWI-interacting RNA (piRNA) pathway produces a class of 26-30-nucleotide (nt) small RNAs and is essential for spermatogenesis and retrotransposon repression. In oocytes, however, its regulation and function are poorly understood. In the present study, we investigated the consequences of loss of piRNA-pathway components in growing oocytes. When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all piRNAs disappeared. This severe loss of piRNA was accompanied by an increase in transcripts derived from specific retrotransposons, especially IAPs...
January 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28110961/synthesis-characterization-and-biological-evaluation-of-novel-chalcone-sulfonamide-hybrids-as-potent-intestinal-alkaline-phosphatase-inhibitors
#18
Syeda Abida Ejaz, Aamer Saeed, Muhammad Nasir Siddique, Zaib Un Nisa, Samiullah Khan, Joanna Lecka, Jean Sévigny, Jamshed Iqbal
Alkaline phosphatase (AP) and ecto-5'-nucleotidase (e5'NT) belong to same family that hydrolyze the extracellular nucleotides and ensure the bioavailability of nucleotides and nucleosides at purinergic receptors. During pathophysiological conditions, the over expression of AP and e5'NT lead to an increased production of adenosine that enhance tumor proliferation, invasiveness, neoangiogenesis and disrupts the body antitumor response. As both enzymes are abundantly expressed in above mentioned conditions, therefore it is of great interest to synthesize and develop potent inhibitors of these enzymes that augment the antitumor therapy...
January 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28109866/microrna-214-inhibits-the-osteogenic-differentiation-of-human-osteoblasts-through-the-direct-regulation-of-baculoviral-iap-repeat-containing-7
#19
Jianmin Liu, Yan Li, Ming Luo, Zhi Yuan, Jian Liu
Osteoblasts and osteoclasts coordinate to monitor the dynamic osteogenic balance between bone formation and bone resorption. Hence, an investigation of the regulatory mechanisms underlying osteogenic osteoblast differentiation will provide more methods for bone repair and bone regeneration. In the present study, human osteoblast hFOB 1.19 cells were cultured. MicroRNA-214 (miR-214) expression significantly down-regulated during the osteogenic differentiation of hFOB 1.19 cells. In addition, miR-214 overexpression by miR-214 precursor transfection markedly inhibited the expression of alkaline phosphatase (ALP), collagen type I α1 (col1α1) and runt-related transcription factor 2 (Runx2), which concomitantly decreased ALP activity and the number of mineralized nodules but promoted the expression of signal transducer and activator of transcription 1 (STAT1), an osteogenesis blocker...
February 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28106882/combination-of-iap-antagonist-and-ifn%C3%AE-activates-novel-caspase-10-and-ripk1-dependent-cell-death-pathways
#20
Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silke
Peptido-mimetic inhibitor of apoptosis protein (IAP) antagonists (Smac mimetics (SMs)) can kill tumour cells by depleting endogenous IAPs and thereby inducing tumour necrosis factor (TNF) production. We found that interferon-γ (IFNγ) synergises with SMs to kill cancer cells independently of TNF- and other cell death receptor signalling pathways. Surprisingly, CRISPR/Cas9 HT29 cells doubly deficient for caspase-8 and the necroptotic pathway mediators RIPK3 or MLKL were still sensitive to IFNγ/SM-induced killing...
January 20, 2017: Cell Death and Differentiation
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