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https://www.readbyqxmd.com/read/27919005/tracking-listeria-monocytogenes-contamination-and-virulence-associated-characteristics-in-the-ready-to-eat-meat-based-food-products-industry-according-to-the-hygiene-level
#1
A R Henriques, L T Gama, M J Fraqueza
Listeria monocytogenes isolates collected from final products and food contact surfaces of 10 ready-to-eat meat-based food products (RTEMP) producing industries were analyzed to relate their virulence-associated characteristics and genetic profiles with the hygiene assessment of those industries. Together with sample collection, an audit was performed to evaluate the implemented food safety management system and to investigate the specific audit requisites more associated to the occurrence of those L. monocytogenes serogroups frequently related with human disease...
November 21, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27915973/engaging-cell-death-pathways-for-the-treatment-of-rhabdomyosarcoma
#2
Christine C Dobson, Stephanie Langlois, David Grynspan, Kyle N Cowan, Martin Holcik
Rhabdomyosarcoma (RMS), a malignant neoplasm of presumed mesenchymal origin, is the most common soft tissue cancer of childhood. Despite aggressive treatment, resistance to current therapies remains a challenge. The success of most cytotoxic chemotherapies requires intact programmed cell death (apoptosis) pathways. Defects in the cellular apoptotic program play a key role in the pathogenesis of RMS and contribute to chemotherapeutic resistance to current treatments. Targeting and engaging apoptotic pathways using small-molecule IAP antagonists, death-inducing ligands, reestablishing pannexin channel expression and activity, immunotherapies, or a combination of these approaches is expected to improve outcomes in RMS patients...
2016: Critical Reviews in Oncogenesis
https://www.readbyqxmd.com/read/27915971/the-iap-protein-family-smac-mimetics-and-cancer-treatment
#3
Alex Philchenkov, Koh Miura
Since the acquired resistance of cells to apoptosis is one of the major hallmarks of cancer, the endogenous inhibitors of apoptosis can be regarded as promising targets in the design of anticancer therapeutics. In addition to their antiapoptotic activity, inhibitor of apoptosis proteins (IAPs) are able to regulate numerous other cell functions, including proliferation, differentiation, and migration, as well as proinflammatory and immune responses. Study of the IAP family as target molecules in targeted therapies has recently focused on SMAC mimetics as synthetic IAP antagonists that have been under development as promising therapeutics...
2016: Critical Reviews in Oncogenesis
https://www.readbyqxmd.com/read/27913388/iap-antagonists-promote-phagocytosis-of-multiple-myeloma-in-vivo
#4
(no author information available yet)
The IAP antagonist LCL161 has activity against multiple myeloma cells independent of apoptosis.
December 2, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27909997/saururus-chinensis-baill-inhibits-proliferation-and-invasion-of-human-renal-cell-carcinoma-cells-through-inhibition-of-inhibitor-of-apoptosis-protein
#5
Yong Hyun Park, Jung-In Kim, Su Yeon Seo, Eunhye Lee, Hyeon Hoe Kim
OBJECTIVE: To investigate the inhibitory effect of Saururus chinensis Baill on cell viability, apoptosis, invasion capacity and the mechanism involved in human renal cell carcinoma (RCC) cells. METHODS: After treating A498 and ACHN cells with Saururus chinensis Baill extract (0, 25, 50 μg/mL), inhibitory effect of Saururus chinensis Baill were evaluated using tetrazolium salt-based colorimetric assay, flfl ow cytometry analysis, and in vitro Matrigel invasion assay, respectively...
December 1, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27909314/controlled-detonation-evolution-of-necroptosis-in-pathogen-defense
#6
REVIEW
Michelle Brault, Andrew Oberst
Necroptosis is a lytic form of programmed cell death that involves the swelling and rupture of dying cells. While several necroptosis-inducing stimuli have been defined, in most cells this pathway is kept in check by the action of the pro-apoptotic protease caspase-8 and the IAP ubiquitin ligases. How and when necroptosis is triggered under physiological conditions therefore remains a persistent question. Because necroptosis likely arose as a defensive mechanism against viral infection, exploration of this question requires a consideration of host-pathogen interactions, and how the sensing of infection could sensitize cells to necroptosis...
December 2, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27907877/synthesis-alkaline-phosphatase-inhibition-studies-and-molecular-docking-of-novel-derivatives-of-4-quinolones
#7
Mariia Miliutina, Syeda Abida Ejaz, Shafi Ullah Khan, Viktor O Iaroshenko, Alexander Villinger, Jamshed Iqbal, Peter Langer
New and convenient methods for the functionalization of the 4-quinolone scaffold at positions C-1, C-3 and C-6 were developed. The 4-quinolone derivatives were evaluated for their inhibitory potential on alkaline phosphatase isozymes. Most of the compounds exhibit excellent inhibitory activity and moderate selectivity. The IC50 values on tissue non-specific alkaline phosphatase (TNAP) were in the range of 1.34 ± 0.11 to 44.80 ± 2.34 μM, while the values on intestinal alkaline phosphatase (IAP) were in the range of 1...
November 17, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27904150/regulating-the-balance-between-necroptosis-apoptosis-and-inflammation-by-inhibitors-of-apoptosis-proteins
#8
REVIEW
Lazaros Vasilikos, Lisanne M Spilgies, Janin Knop, WWei-Lynn Wong
Understanding how Inhibitors of APoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics to deplete or inhibit the IAPs, specifically cIAP1& 2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to death receptor induced cell death, particularly tumour necrosis factor (TNF). Mouse genetics shows that there is some functional redundancy and the use of Smac mimetics has allowed us to understand how changing the composition of proteins recruited to TNF receptor 1 upon TNF ligation can alter protein complex formation and activation of apoptosis or necroptosis, particularly when caspases are inhibited...
December 1, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27895730/osthole-induces-lung-cancer-cell-apoptosis-through-inhibition-of-inhibitor-of-apoptosis-family-proteins
#9
Xiao-Man Xu, Man-Li Zhang, Yi Zhang, Li Zhao
In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and Embelin inhibited cell proliferation more significantly compared with monotherapy. In addition, morphological analysis and Annexin V/propidium iodide analysis revealed that the combination of Osthole and Embelin enhanced their effect on cell apoptosis...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889570/inhibitor-of-apoptosis-protein-1-regulates-tumor-necrosis-factor-mediated-destruction-of-intestinal-epithelial-cells
#10
Thomas Grabinger, Konstantin J Bode, Janine Demgenski, Carina Seitz, M Eugenia Delgado, Feodora Kostadinova, Cindy Reinhold, Nima Etemadi, Sabine Wilhelm, Matthias Schweinlin, Kay Hänggi, Janin Knop, Christof Hauck, Heike Walles, John Silke, Harald Wajant, Ueli Nachbur, W Wei-Lynn Wong, Thomas Brunner
BACKGROUND AND AIMS: Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibitor of apoptosis proteins (IAPs) in the regulation of TNF-induced cell death in the intestinal epithelium of mice and intestinal organoids. METHODS: RNA from cell lines and tissues and analyzed by quantitative PCR, protein levels were analyzed by immunoblot assays...
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27881001/pathway-crosstalk-analysis-in-prostate-cancer-based-on-protein-protein-network-data
#11
H Y Li, N Jin, Y P Han, X F Jin
Prostate cancer (PCa) is one of the major leading cause in men and no effective biomarkers or therapy have been approved for it to date. This study aimed to explore the molecular mechanisms and identify the potential molecular biomarkers of PCa. The microarray profile GSE38241 including 18 prostate cancer metastasis and 21 normal prostate samples was retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by Limma. DEGs functions were investigated by Gene Ontology (GO) and pathway enrichment analysis...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27878341/initiation-of-forward-gait-with-lateral-occurrence-of-emotional-stimuli-general-findings-and-relevance-for-pedestrians-crossing-roads
#12
D Caffier, C Gillet, L P Heurley, A Bourrelly, F Barbier, J Naveteur
With reference to theoretical models regarding links between emotions and actions, the present study examined whether the lateral occurrence of an emotional stimulus influences spatial and temporal parameters of gait initiation in 18 younger and 18 older healthy adults. In order to simulate road-crossing hazard for pedestrians, slides of approaching cars were used and they were presented in counterbalanced order with threatening slides from the International Affective Picture System (IAPS) and control slides of safe walking areas...
November 22, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27875107/the-effect-of-elevated-intra-abdominal-pressure-on-tlr4-signaling-in-intestinal-mucosa-and-on-intestinal-bacterial-translocation-in-a-rat
#13
Adam Strier, Dragan Kravarusic, Arnold G Coran, Isaac Srugo, Nir Bitterman, Tatiana Dorfman, Yulia Pollak, Ibrahim Matter, Igor Sukhotnik
BACKGROUND: Recent evidence suggests that elevated intra-abdominal pressure (IAP) may adversely affect the intestinal barrier function. Toll-like receptor 4 (TLR-4) is responsible for the recognition of bacterial endotoxin or lipopolysaccharide and for initiation of the Gram-negative septic shock syndrome. The objective of the current study was to determine the effects of elevated IAP on intestinal bacterial translocation (BT) and TLR-4 signaling in intestinal mucosa in a rat model. METHODS: Male Sprague-Dawley rats were randomly assigned to one of two experimental groups: sham animals (Sham) and IAP animals who were subjected to a 15 mmHg pressure pneumoperitoneum for 30 minutes...
November 22, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27873092/molecular-high-order-harmonic-spectra-and-its-application-to-the-generation-of-the-isolated-attosecond-pulse
#14
Li-Qiang Feng, Hang Liu, Wenliang Li, Rich-Samuel Castle
Molecular high-order harmonic generation (HHG) spectra from H2(+) and its application to the generation of the isolated attosecond pulses (IAPs) have been numerically investigated. Results show that (i) the 7th harmonic order is enhanced with the nuclei around the equilibrium internuclear, and as the internuclear distance increased, this enhanced harmonic produces a red-shift (even disappearance). Theoretical analyses show that the electronic transition between the ground and the 1st excited states is responsible for the red-shift enhanced harmonic...
December 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27870810/neonatal-group-b-streptococcus-infections-prevention-strategies-clinical-and-microbiologic-characteristics-in-7-years-of-surveillance
#15
Roberta Creti, Monica Imperi, Alberto Berardi, Marco Pataracchia, Simona Recchia, Giovanna Alfarone, Lucilla Baldassarri
BACKGROUND: The characteristics of group B streptococcus (GBS) neonatal disease in a period of 7 years are reported. METHODS: The estimation of the neonatal GBS disease risk and prevention strategies adopted at delivery in absence of national guidelines were evaluated by the analysis of 3501 questionnaires. Notification of 194 neonatal GBS infections was recorded. In addition, 115 strains from neonatal early and late onset disease (EOD and LOD, respectively) plus 320 strains from pregnant women were analyzed by molecular typing methods and for antibiotic resistance...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27870046/naive-tadpoles-do-not-recognize-recent-invasive-predatory-fishes-as%C3%A2-dangerous
#16
Attila Hettyey, Kerstin E Thonhauser, Veronika Bókony, Dustin J Penn, Herbert Hoi, Matteo Griggio
Invasive alien predators (IAP) are spreading on a global scale-often with devastating ecological effects. One reason for their success may be that prey species fail to recognize them due to a lack of co-evolutionary history. We performed a comprehensive test of this "prey naiveté" hypothesis using a novel approach: we tested whether predator-naive tadpoles of the agile frog (Rana dalmatina) display antipredator behavior upon encountering chemical cues produced by native, invasive (established or recent) or allopatric fishes (four perciforms, four siluriforms, and two cypriniforms)...
November 2016: Ecology
https://www.readbyqxmd.com/read/27869161/therapeutic-targeting-of-necroptosis-by-smac-mimetic-bypasses-apoptosis-resistance-in-acute-myeloid-leukemia-cells
#17
C Safferthal, K Rohde, S Fulda
Resistance to apoptosis, for example due to overexpression of Inhibitor of Apoptosis (IAP) proteins, is associated with poor prognosis in acute myeloid leukemia (AML). Here, we identify that Smac mimetics such as BV6, which antagonizes IAP proteins, elicit necroptosis in AML cells, in which apoptosis is inhibited pharmacologically by caspase inhibitors or genetically by caspase-8 knockdown. Importantly, BV6 triggers necroptosis also in apoptosis-resistant patient-derived AML blasts, underlining the clinical relevance of our findings...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27861568/appropriateness-of-intrapartum-antibiotic-prophylaxis-to-prevent-neonatal-group-b-streptococcus-disease
#18
Aida Bianco, Elisabetta Larosa, Claudia Pileggi, Maria Pavia
The aims of this study were to describe the adherence to CDC guidelines for intrapartum antibiotic prophylaxis (IAP) and to identify possible factors influencing noncompliance with guidelines. We conducted a retrospective study in Italy. Our cohort included women in whom antenatal Group B Streptococcus (GBS) screening was not performed, was performed, but results were not available at the time of labor or delivery and women who were positive for GBS colonization. The indications for complete execution of IAP according to revised CDC guidelines was evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27848260/the-htra2-drosophila-model-of-parkinson-s-disease-is-suppressed-by-the-pro-survival-bcl-2-buffy
#19
P Githure M'Angale, Brian E Staveley
Mutations in High temperature requirement A2 (HtrA2), also designated PARK13, which lead to the loss of its protease activity, have been associated with Parkinson's disease (PD). HtrA2 is a mitochondrial protease that translocates to the cytosol upon the initiation of apoptosis where it participates in the abrogation of inhibitors of apoptosis (IAP) inhibition of caspases. Here, we demonstrate that the loss of the HtrA2 function in the dopaminergic neurons of Drosophila melanogaster results in PD-like phenotypes, and we attempt to restore the age-dependent loss in locomotor ability by co-expressing the sole pro-survival Bcl-2 homologue Buffy...
August 30, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/27843846/an-assessment-of-the-validity-of-the-nutritional-indices-among-under-fives-in-the-catchment-area-of-rural-health-and-training-center-of-a-teaching-institute-in-bareilly
#20
Rashmi Katyal, Shailendra Pratap Singh, Hari Shankar Joshi, Gaurav Joshi, Arun Singh
CONTEXT: Nutritional status is a sensitive indicator of community health and nutrition. There is a growing realization that adequate nutrition is a necessary first step in the improvement of quality of life. Malnutrition and infection are connected by a vicious cycle. It is one of the greatest international health problems and the biggest challenges being faced today. Thus, to know the magnitude of undernutrition among preschool children and to find out the sensitive tool for detection of undernutrition, this study was conducted among children under - 5 years of age...
April 2016: Journal of Family Medicine and Primary Care
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