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https://www.readbyqxmd.com/read/28931475/where-is-the-accountability-to-adolescents
#1
Carmen Barroso, Kul Chandra Gautam
No abstract text is available yet for this article.
September 15, 2017: Lancet
https://www.readbyqxmd.com/read/28928435/tango7-regulates-cortical-activity-of-caspases-during-reaper-triggered-changes-in-tissue-elasticity
#2
Yunsik Kang, Sarah D Neuman, Arash Bashirullah
Caspases perform critical functions in both living and dying cells; however, how caspases perform physiological functions without killing the cell remains unclear. Here we identify a novel physiological function of caspases at the cortex of Drosophila salivary glands. In living glands, activation of the initiator caspase dronc triggers cortical F-actin dismantling, enabling the glands to stretch as they accumulate secreted products in the lumen. We demonstrate that tango7, not the canonical Apaf-1-adaptor dark, regulates dronc activity at the cortex; in contrast, dark is required for cytoplasmic activity of dronc during salivary gland death...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28923498/assessment-of-grammar-optimizes-language-tasks-for-the-intracarotid-amobarbital-procedure
#3
Monika Połczyńska, Taylor Kuhn, S Christine You, Patricia Walshaw, Susan Curtiss, Susan Bookheimer
PURPOSE: A previous study showed that assessment of language laterality could be improved by adding grammar tests to the recovery phase of the intracarotid amobarbital procedure (IAP) (Połczyńska et al. 2014). The aim of this study was to further investigate the extent to which grammar tests lateralize language function during the recovery phase of the IAP in a larger patient sample. METHODS: Forty patients with drug-resistant epilepsy (14 females, thirty-two right-handed, mean age 38...
September 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28920091/selecting-pure-emotion-materials-from-the-international-affective-picture-system-iaps-by-chinese-university-students-a-study-based-on-intensity-ratings-only
#4
Zhicha Xu, Rongsheng Zhu, Chanchan Shen, Bingren Zhang, Qianqian Gao, You Xu, Wei Wang
There is a need to use selected pictures with pure emotion as stimulation or treatment media for basic and clinical research. Pictures from the widely-used International Affective Picture System (IAPS) contain rich emotions, but no study has clearly stated that an emotion is exclusively expressed in its putative IAPS picture to date. We hypothesize that the IAPS images contain at least pure vectors of disgust, erotism (or erotica), fear, happiness, sadness and neutral emotions. Accordingly, we have selected 108 IAPS images, each with a specific emotion, and invited 219 male and 274 female university students to rate only the intensity of the emotion conveyed in each picture...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28910896/-measurement-of-morphological-parameters-of-internal-acousticmeatus-using-thin-section-ct
#5
J M Liu, D D Zhu, G H Jin, X W Zhu, L Li, G W Liu, K L Cheng, Y Q Li
Objective: This study aimed to measure the morphological parameters of the internal acoustic meatus(IAM) and its adjacent structures using temporal-bone thin-section CT(computed tomography). Methods: CT images were obtained from 50 Chinese adult patients (25 males and 25 females, 100 sides) which had no visible lesion in the petrous part of the temporal bone and inner ear, the morphological parameters of all inner ear parts were sectionally measured on the specified plane using SPSS 22.0 software for statistical analysis...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28905083/assessing-exercises-recommended-for-women-at-risk-of-pelvic-floor-disorders-using-multivariate-statistical-techniques
#6
Tania Tian, Stephanie Budgett, Jackie Smalldridge, Lynsey Hayward, James Stinear, Jennifer Kruger
INTRODUCTION AND HYPOTHESIS: There is a widely held, but untested, belief that certain exercises and activities generate intraabdominal pressure (IAP) that may compromise the function of the pelvic floor muscles. Women with, or at risk of, pelvic floor disorders are advised therefore to refrain from these exercises and activities in order to theoretically protect their pelvic floor. The aim of this study was to compare IAPs generated during exercises of different types that are recommended to women as pelvic floor "safe" with those generated during the corresponding conventional exercises that women are typically cautioned against...
September 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28901499/transfection-with-livin-and-survivin-shrna-inhibits-the-growth-and-proliferation-of-non%C3%A2-small-cell-lung-cancer-cells
#7
Qinmiao Huang, Yiming Zeng, Huihuang Lin, Huaping Zhang, Dongyong Yang
Lung cancer is reported to be a major public health issue worldwide and the overall prognosis of patients remains poor. The expression levels of Livin and Survivin, of the inhibitors of apoptosis (IAP) family, are associated with prognostic significance in the majority of solid tumors. Therefore, in the presents study, short hairpin (sh)RNA expression vectors inhibiting the Livin and Survivin genes were constructed to examine the effects of the transfection of Livin shRNA and/or Survivin shRNA on the biological functions of tumor cells...
September 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900184/survivin-and-xiap-two-potential-biological-targets-in-follicular-thyroid-carcinoma
#8
Thomas A Werner, Levent Dizdar, Inga Nolten, Jasmin C Riemer, Sabrina Mersch, Sina C Schütte, Christiane Driemel, Pablo E Verde, Katharina Raba, Stefan A Topp, Matthias Schott, Wolfram T Knoefel, Andreas Krieg
Follicular thyroid carcinoma's (FTC) overall good prognosis deteriorates if the tumour fails to retain radioactive iodine. Therefore, new druggable targets are in high demand for this subset of patients. Here, we investigated the prognostic and biological role of survivin and XIAP in FTC. Survivin and XIAP expression was investigated in 44 FTC and corresponding non-neoplastic thyroid specimens using tissue microarrays. Inhibition of both inhibitor of apoptosis proteins (IAP) was induced by shRNAs or specific small molecule antagonists and functional changes were investigated in vitro and in vivo...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894687/the-pedicles-are-not-the-densest-regions-of-the-lumbar-vertebrae-implications-for-bone-quality-assessment-and-surgical-treatment-strategy
#9
Eric A Hohn, Bryant Chu, Audrey Martin, Elizabeth Yu, Connor Telles, Jeremi Leasure, Tennyson L Lynch, Dimitriy Kondrashov
STUDY DESIGN: Cadaver study. OBJECTIVE: To determine the bone density of lumbar vertebral anatomic subregions. Bone mineral density (BMD) is a major factor in osseous fixation construct strength. The standard region for implant fixation of the spine is the pedicle; however, other regions may be more viable options with higher bone quality. METHODS: Using computed tomography images, the spine was digitally isolated by applying a filter for adult bone...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28892098/correlation-between-e-cadherin-interactions-survivin-expression-and-apoptosis-in-mdck-and-ts-src-mdck-cell-culture-models
#10
Janne Capra, Sinikka Eskelinen
Survivin, a member of inhibitor of apoptosis (IAP) protein family, is a multifunctional protein expressed in most cancers. In addition to inhibition of apoptosis, it regulates proliferation and promotes migration. Its presence and function in cells is strongly regulated via transcription factors, intracellular localization, and degradation. We analyzed the presence of survivin at protein level in various culture environments and under activation of Src tyrosine kinase in epithelial canine kidney MDCK cells in order to elucidate factors controlling survivin 'lifespan'...
September 11, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28891510/influence-of-visual-elicitation-over-emotion-regulation-an-investigation-employing-the-heart-rate-variability
#11
María J Lado, P Cuesta, Alejandro García Caballero, Xosé A Vila
Several works studied the elicitation of emotions through the exposure of individuals to relevant stimuli, using spectral analysis of Heart Rate Variability (HRV) when people are subject to emotional elicitation. If correlation exists between HRV and emotional responses, spectral analysis can be used to study emotion regulation under external stimuli. In this work, we studied the relationship between visual elicitation and emotion regulation, employing HRV. Images (with pleasant, unpleasant and neutral emotional content) were selected from the IAPS (International Affective Picture System) dataset...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28888465/predicting-and-evaluation-the-severity-in-acute-pancreatitis-using-a-new-modeling-built-on-body-mass-index-and-intra-abdominal-pressure
#12
Yang Fei, Kun Gao, Jianfeng Tu, Wei Wang, Guang-Quan Zong, Wei-Qin Li
OBJECT: Acute pancreatitis (AP) keeps as severe medical diagnosis and treatment problem. Early evaluation for severity and risk stratification in patients with AP is very important. Some scoring system such as acute physiology and chronic health evaluation-II (APACHE-II), the computed tomography severity index (CTSI), Ranson's score and the bedside index of severity of AP (BISAP) have been used, nevertheless, there're a few shortcomings in these methods. The aim of this study was to construct a new modeling including intra-abdominal pressure (IAP) and body mass index (BMI) to evaluate the severity in AP...
June 3, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28882582/group-b-streptococcal-infection-in-neonates-and-colonization-in-pregnant-women-an-epidemiological-retrospective-analysis
#13
Ching-Yi Cho, Yi-Hsuan Tang, Yu-Hsuan Chen, Szu-Yao Wang, Yi-Hsin Yang, Ting-Hao Wang, Chang-Ching Yeh, Keh-Gong Wu, Mei-Jy Jeng
BACKGROUND: Group B Streptococcus (GBS) infection is one of the major causes of neonatal morbidity and mortality. Universal GBS screening with intrapartum antibiotic prophylaxis (IAP) in pregnant women were initiated in 2012 in Taiwan. This study aimed to analyze the most recent maternal GBS colonization rate and the changes in neonatal GBS infection rate from 2011 to 2016. METHODS: All pregnant women and their live born neonates between January 2011 and June 2016 were retrospectively reviewed...
August 23, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28881589/decreased-calpain-activity-in-chronic-myeloid-leukemia-impairs-apoptosis-by-increasing-survivin-in-myeloid-progenitors-and-xiap1-in-differentiating-granulocytes
#14
Weiqi Huang, Ling Bei, Elizabeth E Hjort, Elizabeth A Eklund
Chronic Myeloid Leukemia (CML) is characterized by translocations between chromosomes 9 and 22, resulting in expression of Bcr-abl oncogenes. Although the clinical course of CML was revolutionized by development of Bcr-abl-directed tyrosine kinase inhibitors (TKIs), CML is not cured by these agents. Specifically, the majority of subjects relapsed in clinical trials attempting TKI discontinuation, suggesting persistence of leukemia stem cells (LSCs) even in molecular remission. Identifying mechanisms of CML-LSC persistence may suggest rationale therapeutic targets to augment TKI efficacy and lead to cure...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877171/preventable-proportion-of-intubation-associated-pneumonia-role-of-adherence-to-a-care-bundle
#15
Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Emiliano Spera, Giovanni Gallo, Francesco Auxilia, Silvio Brusaferro, Marcello Mario D'Errico, Maria Teresa Montagna, Cesira Pasquarella, Stefano Tardivo, Ida Mura
OBJECTIVE: The aim of the present study was to estimate the preventable proportion of Intubation-Associated Pneumonia (IAP) in the Intensive Care Units (ICUs) participating in the Italian Nosocomial Infections Surveillance in ICUs (SPIN-UTI) network, taking into account differences in intrinsic patients' risk factors, and additionally considering the compliance with the European bundle for IAP prevention. METHODS: A prospective patient-based survey was conducted and all patients staying in ICU for more than 2 days were enrolled in the surveillance...
2017: PloS One
https://www.readbyqxmd.com/read/28873766/occurrence-and-phenotypic-and-molecular-characterization-of-listeriamonocytogenes-and-salmonella-spp-in-slaughterhouses-in-southern-brazil
#16
Mariana Almeida Iglesias, Isabela Schneid Kroning, Luana Tombini Decol, Bernadette Dora Gombossy de Melo Franco, Wladimir Padilha da Silva
This study addressed the occurrence of Listeriamonocytogenes and Salmonella spp. in bovine carcasses at two slaughterhouses in southern Brazil. Then, the antimicrobial susceptibility profile and the virulence potential of the isolates were evaluated. Two hundred carcasses were sampled at four steps of the slaughter process, with L. monocytogenes being isolated in 12 and Salmonella spp. in 17 carcasses. All L. monocytogenes isolates carried the hlyA, prfA, plcA, plcB, actA, iap, mpl, inlA, inlB, inlC, and inlJ genes, while Salmonella spp...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28856619/genomic-analysis-of-a-trichoplusia-ni-betabaculovirus-tngv-with-three-different-viral-enhancing-factors-and-two-unique-genes
#17
Ma de Los Ángeles Bivian-Hernández, Juventino López-Tlacomulco, Everardo Mares-Mares, Jorge E Ibarra, María Cristina Del Rincón-Castro
The complete genome of a Trichoplusia ni granulovirus (TnGV) is described and analyzed. The genome contains 175,360 bp (KU752557), becoming the third largest genome within the genus Betabaculovirus, smaller only than the Xestia c-nigrum GV (XecnGV) (178,733 pb) and the Pseudaletia unipuncta GV (PsunGV) (176,677 pb) genomes. The TnGV genome has a 39.81% C+G content and a total of 180 ORFs were identified, 96 of them in the granulin gene direction and 84 in the opposite direction. A total of 94.38% of the ORFs showed high identity with those of ClanGV, HaGV, and SlGV...
August 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28841179/investigations-of-pro-and-anti-apoptotic-factors-affecting-african-swine-fever-virus-replication-and-pathogenesis
#18
REVIEW
Linda K Dixon, Pedro J Sánchez-Cordón, Inmaculada Galindo, Covadonga Alonso
African swine fever virus (ASFV) is a large DNA virus that replicates predominantly in the cell cytoplasm and is the only member of the Asfarviridae family. The virus causes an acute haemorrhagic fever, African swine fever (ASF), in domestic pigs and wild boar resulting in the death of most infected animals. Apoptosis is induced at an early stage during virus entry or uncoating. However, ASFV encodes anti-apoptotic proteins which facilitate production of progeny virions. These anti-apoptotic proteins include A179L, a Bcl-2 family member; A224L, an inhibitor of apoptosis proteins (IAP) family member; EP153R a C-type lectin; and DP71L...
August 25, 2017: Viruses
https://www.readbyqxmd.com/read/28839364/omega-3-fish-oil-reduces-mortality-due-to-severe-sepsis-with-acute-gastrointestinal-injury-grade-iii
#19
Huaisheng Chen, Wei Wang, Chengying Hong, Ming Zhang, Yingcai Hong, Su Wang, Huadong Zhang
BACKGROUND: Sepsis plays an important role in acute gastrointestinal injury (AGI). Our research was designed to determine the effects of omega-3 fish oil (FO) in patients suffering from severe sepsis combined with AGI III, and the ability of FO to modulate immune function. METHODS: Seventy-eight patients diagnosed with severe sepsis with AGI III and a need for mechanical ventilation were randomized to two groups. In the FO group, 50 g of long chain fatty acid soybean oil (n = 6) and 10 g of FO (n = 3) were administered as total parenteral nutrition (TPN)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28833526/perinatal-lead-pb-exposure-results-in-sex-and-tissue-dependent-adult-dna-methylation-alterations-in-murine-iap-transposons
#20
L Montrose, C Faulk, J Francis, D C Dolinoy
Epidemiological and animal data suggest that adult chronic disease is influenced by early-life exposure-induced changes to the epigenome. Previously, we observed that perinatal lead (Pb) exposure results in persistent murine metabolic- and activity-related effects. Using phylogenetic and DNA methylation analysis, we have also identified novel intracisternal A particle (IAP) retrotransposons exhibiting regions of variable methylation as candidate loci for environmental effects on the epigenome. Here, we now evaluate brain and kidney DNA methylation profiles of four representative IAPs in adult mice exposed to human physiologically relevant levels of Pb two weeks prior to mating through lactation...
August 19, 2017: Environmental and Molecular Mutagenesis
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