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Anurag Bajpai
No abstract text is available yet for this article.
July 18, 2018: Indian Journal of Pediatrics
Steven M Chirieleison, Joseph K Rathkey, Derek W Abbott
The mammalian IAPs, X-linked inhibitor of apoptosis protein (XIAP) and cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), play pivotal roles in innate immune signaling and inflammatory homeostasis, often working in parallel or in conjunction at a signaling complex. IAPs direct both nucleotide-binding oligomerization domain-containing 2 (NOD2) signaling complexes and cell death mechanisms to appropriately regulate inflammation. Although it is known that XIAP is critical for NOD2 signaling and that the loss of cIAP1 and cIAP2 blunts NOD2 activity, it is unclear whether these three highly related proteins can compensate for one another in NOD2 signaling or in mechanisms governing apoptosis or necroptosis...
July 17, 2018: Science Signaling
Yu Tang, Zhi-Ying Zhong, Yan-Feng Liu, Gou-Tai Sheng
DM is often accompanied by macrovascular complications. Obtusifolin, which is an anthraquinone‑based compound with antioxidant activity, is obtained from the seeds of Cassia obtusifolia. In this study, the potential effect of obtusifolin was investigated in human umbilical vein endothelial cells. The results from flow cytometry analysis revealed that pretreatment with obtusifolin depressed the production of cellular reactive oxygen species that was induced by high glucose content. Moreover, the results showed that pretreatment with obtusifolin reduced the level of malondialdehyde, as well as recovered the activities of mitochondrial complex I/III, catalase and superoxide dismutase...
July 5, 2018: Molecular Medicine Reports
James J Young, Joshua S Friedman, Thomas J Oxley, Christina Palmese, Fedor Panov, Saadi Ghatan, Johanna T Fifi, Lara V Marcuse
The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4-30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection...
2018: Epilepsy & Behavior Case Reports
Fancheng Meng, Qiu Li, Yaning Qi, Chengwei He, Chunming Wang, Qingwen Zhang
The polysaccharides obtained from the root of Ilex asprella, namely IAPS-1 and IAPS-2, with immunoregulatory activity were studied. Two polysaccharides were isolated and purified by Cellulose DEAE-52 and Sephadex columns. The structure of IAPS-1 was elucidated as 1,6-linked α-d-glucopyranosyl main chain with branch chain substituted at C-2 and/or C-4 position. For IAPS-2, the backbone is composed of 1, 4-linked α-d-glucose, galactose and rhamnose, and branched chains consists of arabinose, rhamnose and galacturonic acid, as confirmed by partial acid hydrolysis and NMR study...
October 1, 2018: Carbohydrate Polymers
Xiang Zhu, Jinfeng Zhao, Hafiz Muhammad Khalid Abbas, Yunjun Liu, Menglan Cheng, Jue Huang, Wenjuan Cheng, Beibei Wang, Cuiying Bai, Guoying Wang, Wubei Dong
Key message Nine transgenes from different categories, viz. plant defense response genes and anti-apoptosis genes, played combined roles in maize to inhibit the necrotrophic pathogens Rhizoctonia solani and Bipolaris maydis. Maize sheath blight and southern corn leaf blight are major global threats to maize production. The management of these necrotrophic pathogens has encountered limited success due to the characteristics of their lifestyle. Here, we presented a transgenic pyramiding breeding strategy to achieve nine different resistance genes integrated in one transgenic maize line to combat different aspects of necrotrophic pathogens...
July 13, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Joon Young Song, Jae Hyang Lim, Sangyong Lim, Zhi Yong, Ho Seong Seo
Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening...
July 11, 2018: Human Vaccines & Immunotherapeutics
K Neier, D Cheatham, L D Bedrosian, D C Dolinoy
Developmental exposure to phthalates has been implicated as a risk for obesity; however, epidemiological studies have yielded conflicting results and mechanisms are poorly understood. An additional layer of complexity in epidemiological studies is that humans are exposed to mixtures of many different phthalates. Here, we utilize an established mouse model of perinatal exposure to investigate the effects of three phthalates, diethylhexyl phthalate (DEHP), diisononyl phthalate (DINP) and dibutyl phthalate (DBP), on body weight and organ weights in weanling mice...
July 11, 2018: Journal of Developmental Origins of Health and Disease
Fangfeng Liu, Yongjie Sun, Bingqi Liu, Jun Lu, Hongguang Li, Huaqiang Zhu, Hengjun Gao, Xu Zhou, Hong Chang
Insulin-like growth factor-1 (IGF-1), a small polypeptide hormone similar to insulin in protein structures, has been identified as an activator of epithelial-mesenchymal transition (EMT) pathways in several types of cancers. As a member of the inhibitor of apoptosis protein (IAP) family, survivin is implicated in the EMT of some cancers. However, the role of survivin on IGF-1-mediated EMT of hepatocellular carcinoma (HCC) has not been clarified. In the present study, we demonstrated that survivin was involved in the EMT process induced by IGF-1 in HCC cell line SMMC7721...
August 2018: Oncology Reports
Linda C Horianopoulos, Celia K Boone, G D N Gayathri Samarasekera, Gurkirat K Kandola, Brent W Murray
The mountain pine beetle ( Dendroctonus ponderosae ) is an insect native to western North America; however, its geographical range has recently expanded north in BC and east into Alberta. To understand the population structure in the areas of expansion, 16 gene-linked microsatellites were screened and compared to neutral microsatellites using outlier analyses of F st and F ct values. One sex-linked gene, inhibitor of apoptosis ( IAP ), showed a strong signature of positive selection for neo-X alleles and was analyzed for evidence of adaptive variation...
June 2018: Ecology and Evolution
Shu-Mei Chen, Tzu-Kang Lin, Yuan-Yun Tseng, Chiao-Hui Tu, Tai-Ngar Lui, Shiang-Fu Huang, Ling-Ling Hsieh, Ying-Ying Li
Medulloblastoma (MB) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors of apoptosis proteins (IAP) small-molecule inhibitors (LCL161 or LBW242) combined with chemotherapy have synergistic antiproliferative effects on MB cells. The synergistic antitumor effects of combination treatments happen through induction of autophagy and caspase-3/7-activated apoptosis. Here, we investigated the effects of IAP inhibitors or silencing IAP on cell cycle regulation. We discovered that treatment with IAP inhibitors or their combination with conventional chemotherapy (vincristine or cisplatin), as well as RNAi knockdown of cIAP1/2 or XIAP arrested MB cells in the G2/M phase through downregulation of cyclin B1-CDK1 and cyclin A-CDK1/2...
July 9, 2018: Cancer Medicine
Ulrich Mayr, Leonie Fahrenkrog-Petersen, Gonzalo Batres-Baires, Alexander Herner, Sebastian Rasch, Roland M Schmid, Wolfgang Huber, Tobias Lahmer
BACKGROUND: Ascites is a major complication of decompensated liver cirrhosis. Intraabdominal hypertension and structural alterations of parenchyma involve decisive changes in hepatosplanchnic blood flow. Clearance of indo-cyanine green (ICG) is mainly dependent on hepatic perfusion and hepatocellular function. As a consequence, plasma disappearance rate of ICG (ICG-PDR) is rated as a useful dynamic parameter of liver function. This study primarily evaluates the impact of large-volume paracentesis (LVP) on ICG-PDR in critically ill patients with decompensated cirrhosis...
July 6, 2018: Annals of Intensive Care
Dushyant Iyer, Leanne Hunt, Steven A Frost, Anders Aneman
BACKGROUND: Elevated intra-abdominal pressure (IAP) is a common occurrence in mechanically ventilated patients in the intensive care unit (ICU). This study was undertaken to determine the relationship between IAP, pulmonary compliance and the duration of mechanical ventilation. METHODS: A prospective study of 220 consecutively enrolled mechanically ventilated patients admitted to a mixed surgical-medical ICU in a tertiary referral hospital. The IAP was measured at least twice daily, benchmarked against consensus guidelines...
July 5, 2018: Acta Anaesthesiologica Scandinavica
H Chertkow
An international committee set up through the IAP for Health met to develop an action plan for dementia. Comprehensive international and national initiatives should move forward with calls for action that include increased public awareness regarding brain health and dementia, support for a broad range of dementia research objectives, and investment in national health care systems to ensure timely competent person-centred care for individuals with dementia. The elements of such action plans should include: 1) Development of national plans including assessment of relevant lifecourse risk and protective factors; 2) Increased investments in national research programs on dementia with approximately 1% of the national annual cost of the disease invested; 3) Allocating funds to support a broad range of biomedical, clinical, and health service and systems research; 4) Institution of risk reduction strategies; 5) Building the required trained workforce (health care workers, teachers, and others) to deal with the dementia crisis; 6) Ensuring that it is possible to live well with dementia; and 7) Ensuring that all have access to prevention programs, care, and supportive living environments...
2018: Journal of Prevention of Alzheimer's Disease
Juha Wilenius, Henri Lehtinen, Ritva Paetau, Riitta Salmelin, Erika Kirveskari
OBJECTIVE: The intracarotid amobarbital procedure (IAP) is the current "gold standard" in the preoperative assessment of language lateralization in epilepsy surgery candidates. It is, however, invasive and has several limitations. Here we tested a simple noninvasive language lateralization test performed with magnetoencephalography (MEG). METHODS: We recorded auditory MEG responses to pairs of vowels and pure tones in 16 epilepsy surgery candidates who had undergone IAP...
2018: PloS One
Se-Ra Lee, Hua Jin, Won-Tae Kim, Won-Jung Kim, Sung Zoo Kim, Sun-Hee Leem, Soo Mi Kim
Resveratrol (RSV) is a polyphenolic compound that naturally occurs in grapes, peanuts and berries. Considerable research has been conducted to determine the benefits of RSV against various human cancer types. Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability and has decreased expression in human cancer. The present study investigated the biological effect of RSV on TTP gene regulation in colon cancer cells. RSV inhibited the proliferation and invasion/metastasis of HCT116 and SNU81 colon cancer cells...
June 25, 2018: International Journal of Oncology
Kota Tayashiki, Hiroaki Kanehisa, Naokazu Miyamoto
Tayashiki, K, Kanehisa, H, and Miyamoto, N. Does intra-abdominal pressure have a causal effect on muscle strength of hip and knee joints? J Strength Cond Res XX(X): 000-000, 2018-It remains unclear whether intra-abdominal pressure (IAP) has a causal effect on lower-limb muscle strength. This study aimed to clarify whether or not changes in IAP, induced by changing breathing state, influence muscle strength of hip and knee extensor and flexor. Eighteen healthy males (age: 22.0 ± 2.2 years, height: 1.71 ± 0...
June 25, 2018: Journal of Strength and Conditioning Research
Oscar Diaz-Cambronero, Blas Flor Lorente, Guido Mazzinari, Maria Vila Montañes, Nuria García Gregorio, Daniel Robles Hernandez, Luis Enrique Olmedilla Arnal, Maria Pilar Argente Navarro, Marcus J Schultz, Carlos L Errando
BACKGROUND: While guidelines for laparoscopic abdominal surgery advise using the lowest possible intra-abdominal pressure, commonly a standard pressure is used. We evaluated the feasibility of a predefined multifaceted individualized pneumoperitoneum strategy aiming at the lowest possible intra-abdominal pressure during laparoscopic colorectal surgery. METHODS: Multicenter prospective study in patients scheduled for laparoscopic colorectal surgery. The strategy consisted of ventilation with low tidal volume, a modified lithotomy position, deep neuromuscular blockade, pre-stretching of the abdominal wall, and individualized intra-abdominal pressure titration; the effect was blindly evaluated by the surgeon...
June 27, 2018: Surgical Endoscopy
P Marcos-Neira, F Zubia-Olaskoaga, S López-Cuenca, L Bordejé-Laguna
Background: The aim of this study was to analyse the relationship between intra-abdominal hypertension (IAH) and severity of acute pancreatitis (AP) measured by the revised Atlanta classification (RAC) and determinant-based classification (DBC). Secondary objectives were to assess IAH as a predictor of morbidity and mortality in the ICU. Methods: This prospective international observational study included patients admitted to the ICU with AP and at least one organ failure...
December 2017: BJS open
Carlo Baggio, Luca Gambini, Parima Udompholkul, Ahmed F Salem, Alexander Aronson, Ada Dona, Estelle Troadec, Flavia Pichiorri, Maurizio Pellecchia
Recently we reported that rapid determination of enthalpy of binding can be achieved for a large number of congeneric agents or in combinatorial libraries, fairly efficiently. We show that using a Thermodynamic Craig plot can be very useful in dissecting the enthalpy and entropy contribution of different substituents on a common scaffold, in order to design potent, selective or pan-active compounds. In our implementation, the approach identified a critical Lys residue in the BIR3 domain of XIAP. We report for the first time that it is possible to target such residue covalently to attain potent and selective agents...
June 25, 2018: Journal of Medicinal Chemistry
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