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Cognitive and d vitamin

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https://www.readbyqxmd.com/read/29038561/vitamin-d-and-cognitive-function-a-mendelian-randomisation-study
#1
Jane Maddock, Ang Zhou, Alana Cavadino, Elżbieta Kuźma, Yanchun Bao, Melissa C Smart, Kai-Uwe Saum, Ben Schöttker, Jorgen Engmann, Marie Kjærgaard, Ville Karhunen, Yiqiang Zhan, Terho Lehtimäki, Suvi P Rovio, Liisa Byberg, Jari Lahti, Pedro Marques-Vidal, Abhijit Sen, Laura Perna, Henrik Schirmer, Archana Singh-Manoux, Juha Auvinen, Nina Hutri-Kähönen, Mika Kähönen, Lena Kilander, Katri Räikkönen, Håkan Melhus, Erik Ingelsson, Idris Guessous, Katja E Petrovic, Helena Schmidt, Reinhold Schmidt, Peter Vollenweider, Lars Lind, Johan G Eriksson, Karl Michaëlsson, Olli T Raitakari, Sara Hägg, Nancy L Pedersen, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Juha Veijola, Mika Kivimaki, Rolf Jorde, Hermann Brenner, Meena Kumari, Chris Power, David J Llewellyn, Elina Hyppönen
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017462/vitamin-d-deficiency-was-common-among-nursing-home-residents-and-associated-with-dementia-a-cross-sectional-study-of-545-swedish-nursing-home-residents
#2
Rebeka Arnljots, Jörgen Thorn, Marie Elm, Michael Moore, Pär-Daniel Sundvall
BACKGROUND: Residents of nursing homes may have low 25-hydroxyvitamin D (25OHD) concentrations. Associations between vitamin D and cognitive performance, dementia and susceptibility to infections are not clearly established. The aim of this study was to investigate the prevalence of vitamin D deficiency and to identify associated factors among residents of nursing homes for elderly. METHODS: In this cross-sectional study blood samples for analysis of 25OHD were collected from all participating residents of Swedish nursing homes for the elderly from January to March 2012...
October 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28985720/effects-of-homocysteine-on-white-matter-diffusion-parameters-in-alzheimer-s-disease
#3
Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang, Po-Chou Chen
BACKGROUND: The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined their associations with homocysteine level, and tested the clinical significance of the diffusion tensor imaging parameters and homocysteine level in correlation analysis with cognitive test scores...
October 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28984616/the-role-of-vitamin-d-in-disease-progression-in-early-parkinson-s-disease
#4
Isobel Sleeman, Terry Aspray, Rachael Lawson, Shirley Coleman, Gordon Duncan, Tien K Khoo, Inez Schoenmakers, Lynn Rochester, David Burn, Alison Yarnall
BACKGROUND: Previous cross-sectional studies have shown that Parkinson's disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients. OBJECTIVE: The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period...
October 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28980345/exercise-physiology-and-nutritional-perspectives-of-elite-soccer-refereeing
#5
REVIEW
Kai Schenk, Mario Bizzini, Hannes Gatterer
Referees are an integral part of soccer and their performance is fundamental for regular match flow, irrespective of the competition level or age classes. So far, scientific interest was mainly limited to aspects of exercise physiology and match performance of soccer referees, whereas recommendations for nutrition were adopted from active professional soccer. In contrast to elite soccer players most referees are non-professional and engaged in different occupations. Furthermore, elite referees and soccer players differ in regard to age, body composition, aerobic capacity and training load...
October 5, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28974267/efficacy-of-a-multi-component-exercise-programme-and-nutritional-supplementation-on-musculoskeletal-health-in-men-treated-with-androgen-deprivation-therapy-for-prostate-cancer-impact-study-protocol-of-a-randomised-controlled-trial
#6
Patrick J Owen, Robin M Daly, Patricia M Livingston, Niamh L Mundell, Jack Dalla Via, Jeremy L Millar, Steve F Fraser
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is a systemic treatment shown to increase survival in selected patients with prostate cancer. The use of ADT continues to increase for all stages and grades of prostate cancer despite known treatment-induced adverse effects. The primary aim of this study is to examine the efficacy of a targeted, multi-component resistance and impact-loading exercise programme together with a daily protein-, calcium- and vitamin D-enriched supplement on bone health in men treated with ADT for prostate cancer...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#7
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28933265/the-role-of-vitamin-d-in-multiple-sclerosis-biology-biochemistry-epidemiology-and-potential-roles-in-treatment
#8
Steve Simpson, Ingrid van der Mei, Bruce Taylor
Multiple sclerosis (MS) is a progressive, demyelinating condition of the central nervous system, manifesting in loss or alterations in function of sensory, motor and cognitive function. Of the various environmental and behavioural risk factors identified as playing a role in MS onset and progression, perhaps none has been as consistent as vitamin D. OBJECTIVE: In this review, we will endeavour to present a general background on the role of vitamin D in human health and particularly in MS, as well as the substantial epidemiological evidence in support of vitamin D's role in MS...
September 21, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28915381/adult-vitamin-d-deficiency-exacerbates-impairments-caused-by-social-stress-in-balb-c-and-c57bl-6-mice
#9
Natalie J Groves, Mei Zhou, Dhanisha J Jhaveri, John J McGrath, Thomas H J Burne
Vitamin D deficiency is prevalent in adults throughout the world. Epidemiological studies have shown significant associations between vitamin D deficiency and an increased risk of various neuropsychiatric and neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease and cognitive impairment. However, studies based on observational epidemiology cannot address questions of causality; they cannot determine if vitamin D deficiency is a causal factor leading to the adverse health outcome...
September 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28870545/arterial-stiffness-and-cognitive-impairment
#10
REVIEW
Xiaoxuan Li, Peiyuan Lyu, Yanyan Ren, Jin An, Yanhong Dong
BACKGROUND: Arterial stiffness is one of the earliest indicators of changes in vascular wall structure and function and may be assessed using various indicators, such as pulse-wave velocity (PWV), the cardio-ankle vascular index (CAVI), the ankle-brachial index (ABI), pulse pressure (PP), the augmentation index (AI), flow-mediated dilation (FMD), carotid intima media thickness (IMT) and arterial stiffness index-β. Arterial stiffness is generally considered an independent predictor of cardiovascular and cerebrovascular diseases...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28860112/risk-factors-for-falls-in-older-patients-with-cancer
#11
Xiaotao Zhang, Ming Sun, Suyu Liu, Cheuk Hong Leung, Linda Pang, Uday R Popat, Richard Champlin, Holly M Holmes, Vicente Valero, Colin P Dinney, Debu Tripathy, Beatrice J Edwards
OBJECTIVES: A rising number of patients with cancer are older adults (65 years of age and older), and this proportion will increase to 70% by the year 2020. Falls are a common condition in older adults. We sought to assess the prevalence and risk factors for falls in older patients with cancer. METHODS: This is a single-site, retrospective cohort study. Patients who were receiving cancer care underwent a comprehensive geriatric assessments, including cognitive, functional, nutritional, physical, falls in the prior 6 months and comorbidity assessment...
August 31, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28832923/vitamin-d-mentia-is-vitamin-d-optional-or-essential-for-preventing-late-life-cognitive-decline
#12
EDITORIAL
Cedric Annweiler
No abstract text is available yet for this article.
October 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28818511/vitamin-d-enhances-antiepileptic-and-cognitive-effects-of-lamotrigine-in-pentylenetetrazole-kindled-rats
#13
Ali F Abdel-Wahab, Mohamed A Afify, Amal M Mahfouz, Naiyer Shahzad, Ghazi A Bamagous, Saeed S Al Ghamdi
Despite long use of antiepileptic drugs, it remains a challenge to achieve seizure control while reducing adverse effects and preventing cognitive impairment. Several lines of evidence suggest a role of vitamin D in epilepsy. So this study aimed to investigate the effect of vitamin D on epileptogenesis, cognitive dysfunction and antiepileptic activity of lamotrigine, in a rat model of chemical kindling. Rats were kindled by pentylenetetrazole injections every other day over four weeks, together with daily oral treatment by either vehicle, vitamin D, lamotrigine or combination of vitamin D and lamotrigine...
August 14, 2017: Brain Research
https://www.readbyqxmd.com/read/28807865/novel-compound-heterozygous-mutations-identified-by-whole-exome-sequencing-in-a-japanese-patient-with-geroderma-osteodysplastica
#14
Ryojun Takeda, Masaki Takagi, Hiroyuki Shinohara, Hiroshi Futagawa, Satoshi Narumi, Tomonobu Hasegawa, Gen Nishimura, Hiroshi Yoshihashi
Geroderma osteodysplastica (GO) is a subtype of cutis laxa syndrome characterized by congenital wrinkly skin, a prematurely aged face, extremely short stature, and osteoporosis leading to recurrent fractures. GO exhibits an autosomal recessive inheritance pattern and is caused by loss-of-function mutations in GORAB, which encodes a protein important for Golgi-related transport. Using whole exome sequencing, we identified novel compound heterozygous nonsense mutations in the GORAB in a GO patient. The patient was a 14-year-old Japanese boy...
August 11, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28807434/nutritional-strategies-in-the-management-of-alzheimer-disease-systematic-review-with-network-meta-analysis
#15
Shirley Steffany Muñoz Fernández, Terry Ivanauskas, Sandra Maria Lima Ribeiro
BACKGROUND: Alzheimer disease (AD) is the major cause of dependency and disability in the elderly. Numerous studies have sought to achieve its prevention and/or management examining a role for modifiable risk factors, such as nutrition. This work aims to investigate the effects of food and/or nutrients in the management of AD at different stages. METHODS: Electronic databases were searched for clinical trials examining the effect of nutrient intervention in individuals with AD, compared with placebo, published up to 2014...
October 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28768841/association-of-parathyroid-hormone-with-20-year-cognitive-decline-the-aric-study
#16
MULTICENTER STUDY
Samuel M Kim, Di Zhao, Andrea L C Schneider, Sai Krishna Korada, Pamela L Lutsey, Eliseo Guallar, Alvaro Alonso, B Gwen Windham, Rebecca F Gottesman, Erin D Michos
OBJECTIVE: We hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort. METHODS: We studied 12,964 middle-aged white and black ARIC participants without a history of prior stroke who, in 1990-1992 (baseline), had serum PTH levels measured and cognitive function testing, with repeat cognitive testing performed at up to 2 follow-up visits. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summed as a global Z score...
August 29, 2017: Neurology
https://www.readbyqxmd.com/read/28758188/a-systematic-review-and-meta-analysis-of-the-effect-of-low-vitamin-d-on-cognition
#17
REVIEW
Alicia M Goodwill, Cassandra Szoeke
BACKGROUND/OBJECTIVE: With an aging population and no cure for dementia on the horizon, risk factor modification prior to disease onset is an urgent health priority. Therefore, this review examined the effect of low vitamin D status or vitamin D supplementation on cognition in midlife and older adults without a diagnosis of dementia. DESIGN: Systematic review and random effect meta-analysis. SETTING: Observational (cross-sectional and longitudinal cohort) studies comparing low and high vitamin D status and interventions comparing vitamin D supplementation with a control group were included in the review and meta-analysis...
October 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28752139/association-between-serum-vitamin-b12-level-and-frailty-in-older-adults
#18
Ozge Dokuzlar, Pinar Soysal, Ahmet Turan Isik
OBJECTIVE: Frailty is associated with recurrent falls, fractures, limitation of daily living activities, cognitive impairment, increase in hospitalization, placement in nursing home, and mortality rate in older adults. Although malnutrition is one of the most important etiological factors, role of micronutrients is unclear. The aim of this study was to investigate association between frailty and vitamin B12, which has been demonstrated to be related to numerous geriatric syndromes. METHODS: Total of 335 patients who presented at geriatric outpatient clinic and underwent comprehensive geriatric assessment were included in this study...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28747485/developmental-vitamin-d-deficiency-affects-spatial-learning-in-wistar-rats
#19
Anwar N Al-Harbi, Khalid M Khan, Abdur Rahman
Background: Vitamin D deficiency is a global problem. Recent evidence suggests that vitamin D is involved in brain development and function. Vitamin D deficiency has been associated with poor cognitive function in adults, but the effect of developmental vitamin D deficiency (DVDD) on cognitive function and brain development in children has not been well established.Objective: We explored the effects of DVDD on cognitive functions and brain morphology of rat pups.Methods: Wistar rat pups born to control and vitamin D-deficient dams were divided into 4 groups: control (C), deficient during gestation (dG), deficient during lactation (dL), and deficient during gestation and lactation (dGL)...
September 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28744225/is-it-time-to-begin-a-public-campaign-concerning-frailty-and-pre-frailty-a-review-article
#20
REVIEW
Jerzy Sacha, Magdalena Sacha, Jacek Soboń, Zbigniew Borysiuk, Piotr Feusette
Frailty is a state that encompasses losses in physical, psychological or social domains. Therefore, frail people demonstrate a reduced potential to manage external stressors and to respond to life incidents. Consequently, such persons are prone to various adverse consequences such as falls, cognitive decline, infections, hospitalization, disability, institutionalization, and death. Pre-frailty is a condition predisposing and usually preceding the frailty state. Early detection of frailty (i.e., pre-frailty) may present an opportunity to introduce effective management to improve outcomes...
2017: Frontiers in Physiology
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