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Assisted reproduction technology

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https://www.readbyqxmd.com/read/29775803/assisted-reproductive-technologies-and-imprinting-disorders-results-of-a-study-from-a-french-congenital-malformations-registry
#1
Audrey Uk, Sophie Collardeau-Frachon, Quentin Scanvion, Lucas Michon, Emmanuelle Amar
INTRODUCTION: Assisted Reproductive Technologies (ART) is increasingly used to help infertile couples to have children around the world. A number of studies have been published reporting an increased risk of major malformations in children born following ART, especially an increased incidence of epigenetic diseases (ED). This study aimed to assess the incidence of epigenetic diseases with affected imprinting genes in infants or children from pregnancies obtained through IVF/ICSI compared to infants or children from pregnancies obtained spontaneously...
May 15, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29774275/comparative-economic-study-of-the-use-of-corifollitropin-alfa-and-daily-rfsh-for-controlled-ovarian-stimulation-in-older-patients-cost-minimization-analysis-based-on-the-pursue-study
#2
Gorka Barrenetxea, Juan Antonio García-Velasco, Belén Aragón, Jordi Osset, Max Brosa, Noemí López-Martínez, Buenaventura Coroleu
This study presents an economic assessment of controlled ovarian stimulation in assisted reproductive technology procedures in Spain, comparing the use of corifollitropin alfa and various forms of recombinant follicle-stimulating hormone (rFSH) in women of advanced maternal age. A cost-minimization analysis (CMA) was performed to assess the cost per cycle of controlled controlled ovarian stimulation, including only direct costs associated with the stimulation phase. The CMA was based on the population characteristics, the protocol, and the results obtained from the PURSUE study, taking into account 9 days of controlled controlled ovarian stimulation and 300 IU rFSH/day...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774271/gatekeepers-for-infertility-treatment-views-of-art-providers-concerning-referrals-by-non-art-providers
#3
Robert Klitzman
Many patients who might benefit from treatment using assisted reproductive technology (ART) do not receive it, raising critical questions of why, and how best to overcome existing barriers. In-depth interviews of approximately 1 h each were conducted with 27 ART providers (17 physicians and 10 other healthcare providers). These interviewees suggest that non-ART providers may serve as gatekeepers in a complex system, involving not only individual-level, but also dyadic and institutional, processes and factors related to provider-patient relationships...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774270/lack-of-association-between-receiving-art-treatment-and-parental-psychological-distress-during-pregnancy-preliminary-findings-of-the-japan-environment-and-children-s-study
#4
Kouichi Yoshimasu, Akiko Sato, Naoko Miyauchi, Kanami Tsuno, Hidekazu Nishigori, Kunihiko Nakai, Takahiro Arima
In a nationwide population-based birth cohort study in Japan, pregnant women and their partners were evaluated for psychological distress as part of the first and second/third trimester health checks. Participants were divided into three groups: an infertility group receiving assisted reproductive technology (ART) treatment (239 mothers and 151 fathers); an infertility group receiving non-ART treatment (350 mothers and 215 fathers); and a spontaneous pregnancy group (8514 mothers and 5110 fathers). Data on maternal and child health as well as basic characteristics were collected via medical records and self-administered questionnaires...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774269/differences-in-the-utilization-of-gestational-surrogacy-between-states-in-the-u-s
#5
Kiran M Perkins, Sheree L Boulet, Aaron D Levine, Denise J Jamieson, Dmitry M Kissin
Gestational surrogacy policy in the USA varies by state, but information on state differences is lacking. This study used data from the National Assisted Reproductive Technology Surveillance System from 2010 to 2014 to calculate state differences in gestational carrier cycle characteristics. Of the 662,165 in-vitro fertilization cycles in the USA between 2010 and 2014, 16,148 (2.4%) used gestational carriers. Non-USA residents accounted for 18.3% of gestational carrier cycles, and 29.1% of gestational carrier cycles by USA residents were performed in a state other than the state of residence of the intended parent...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774265/assisted-reproduction-and-middle-east-kinship-a-regional-and-religious-comparison
#6
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Soraya Tremayne, Zeynep B Gürtin
This article compares the use of assisted reproductive technology (ART) and resultant kinship formations in four Middle Eastern settings: the Sunni Muslim Arab world, the Sunni Muslim but officially 'secular' country of Turkey, Shia Muslim Iran and Jewish Israel. This four-way comparison reveals considerable similarities, as well as stark differences, in matters of Middle Eastern kinship and assisted reproduction. The permissions and restrictions on ART, often determined by religious decrees, may lead to counter-intuitive outcomes, many of which defy prevailing stereotypes about which parts of the Middle East are more 'progressive' or 'conservative'...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29773834/embryonic-pou5f1-is-required-for-expanded-bovine-blastocyst-formation
#7
Bradford W Daigneault, Sandeep Rajput, George W Smith, Pablo J Ross
POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification. The role of embryonic POU5F1 in blastocyst formation and cell lineage specification differs between mammalian species but remains completely unknown in cattle. The CRISPR/Cas9 system was utilized for targeted disruption of the POU5F1 gene by direct injection into zygotes. Disruption of the bovine POU5F1 locus prevented blastocyst formation and was associated with embryonic arrest at the morula stage...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768933/psychiatric-disorders-in-women-and-men-up-to-five-years-after-undergoing-assisted-reproductive-technology-treatment-a-prospective-cohort-study
#8
Helena Volgsten, Lone Schmidt, Agneta Skoog Svanberg, Lisa Ekselius, Inger Sundström Poromaa
This is a prospective cohort study with the objective to describe psychiatric disorders, such as any mood and anxiety disorders, in both women and men five years after assisted reproductive technology (ART). The Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), was used as the diagnostic tool to evaluate psychiatric disorders. Logistic regression analysis was used to calculate odds ratios (ORs) and confidence interval (CI) for factors associated with psychiatric disorders at the follow-up...
May 17, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29757581/transmyometrial-embryo-transfer-as-a-useful-method-to-overcome-difficult-embryo-transfers-a-single-center-retrospective-study
#9
Janisse Ferreri Dos Anjos, Emma Gabriela Portillo Osorio, Joana Peñarrubia, Ester Vidal, Francisco Fábregues Gasol
OBJECTIVE: Pregnancy after an embryo transfer depends largely on embryo quality, endometrial receptivity, and the technique used in the embryo transfer. Embryo transfers have been reported as inevitably traumatic and difficult for 5-7% of patients in assisted reproduction treatment. In these cases, transmyometrial embryo transfer should be considered as a suitable method to overcome difficult embryo transfers. The aim of this study was to report our experience with this technique and analyze its causes, results and complications...
May 14, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29753922/beckwith-wiedemann-syndrome-a-population-based-study-on-prevalence-prenatal-diagnosis-associated-anomalies-and-survival-in-europe
#10
Ingeborg Barisic, Ljubica Boban, Diana Akhmedzhanova, Jorieke E H Bergman, Clara Cavero-Carbonell, Ieva Grinfelde, Anna Materna-Kiryluk, Anna Latos-Bielenska, Hanitra Randrianaivo, Natalya Zymak-Zakutnya, Ivona Sansovic, Monica Lanzoni, Joan K Morris
Beckwith Wiedemann syndrome is a complex developmental disorder characterized by somatic overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycemia, and predisposition to embryonal tumors. We present epidemiological and clinical aspects of patients with Beckwith Wiedemann syndrome diagnosed prenatally or in the early years of life, using data from EUROCAT (European Surveillance of Congenital Anomalies) registries. The study population consisted of 371 cases identified between January 1990 and December 2015 in 34 registries from 16 European countries...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29752296/melatonin-attenuates-postovulatory-oocyte-dysfunction-by-regulating-sirt1-expression
#11
Qingling Yang, Shanjun Dai, Xiaoyan Luo, Jing Zhu, Fangyuan Li, Jinhao Liu, Guidong Yao, Yingpu Sun
The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration as a result of the aging process. Melatonin is considered an anti-aging agent. However, the underlying mechanisms of how melatonin improves the quality of postovulatory aged oocytes remain largely unclear. In this study, by using mouse model, we found that there were elevated ROS levels and impaired mitochondrial function demonstrated by reduced mitochondrial membrane potential (ΔΨm) and increased mitochondrial aggregation in oocytes aged 24 h, accompanied by an increased number of meiotic errors, unregulated autophagy-related proteins and early apoptosis, which led to decreased oocyte quality and disrupted developmental competence...
May 11, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29749276/cryopreservation-of-low-number-of-human-spermatozoa-which-is-better-vapor-phase-or-direct-submerging-in-liquid-nitrogen
#12
Akram Hosseini, Mohammad Ali Khalili, Ali Reza Talebi, Azam Agha-Rahimi, Saeed Ghasemi-Esmailabad, Bryan Woodward, Nahid Yari
Cryopreservation and subsequent survival of semen samples with low numbers of human spermatozoa in assisted reproductive technology (ART) facilities can be challenging. The aim of this study was to compare the quality of warmed human spermatozoa following vitrification using direct submerging (DS) in liquid nitrogen (LN2 ) or with LN2 vapour (V). Normozoospermic ejaculates were prepared by the swim-up technique and the motile sperm fraction was divided into three groups: (i) fresh (control); (ii) DS methods in LN2 (DS Group); or (iii) cryopreserved in V (Group V)...
May 11, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29746523/correction-assisted-reproductive-technology-and-newborn-size-in-singletons-resulting-from-fresh-and-cryopreserved-embryos-transfer
#13
Galit Levi Dunietz, Claudia Holzman, Yujia Zhang, Nicole M Talge, Chenxi Li, David Todem, Sheree L Boulet, Patricia McKane, Dmitry M Kissin, Glenn Copeland, Dana Bernson, Michael P Diamond
[This corrects the article DOI: 10.1371/journal.pone.0169869.].
2018: PloS One
https://www.readbyqxmd.com/read/29743320/prospective-longitudinal-study-of-the-pregnancy-dna-methylome-the-us-pregnancy-race-environment-genes-preg-study
#14
Dana M Lapato, Sara Moyer, Emily Olivares, Ananda B Amstadter, Patricia A Kinser, Shawn J Latendresse, Colleen Jackson-Cook, Roxann Roberson-Nay, Jerome F Strauss, Timothy P York
PURPOSE: The goal of the Pregnancy, Race, Environment, Genes study was to understand how social and environmental determinants of health (SEDH), pregnancy-specific environments (PSE) and biological processes influence the timing of birth and account for the racial disparity in preterm birth. The study followed a racially diverse longitudinal cohort throughout pregnancy and included repeated measures of PSE and DNA methylation (DNAm) over the course of gestation and up to 1 year into the postpartum period...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29741247/prenatal-and-preimplantation-diagnosis-of-hemoglobinopathies
#15
REVIEW
C Vrettou, G Kakourou, T Mamas, J Traeger-Synodinos
The hemoglobinopathies, as a group, are one of the most common serious monogenic diseases in the world. An accepted and widely adopted approach to reduce the number of new cases involves carrier-screening programs, with the option of prenatal diagnosis (PND) or preimplantation diagnosis (preimplantation genetic testing for monogenic disease, PGT-M) for carrier couples. The aim of PND is to provide an accurate result as early in pregnancy as possible, which necessitates prior identification of the parental disease-causing mutations, as well as safe and timely biopsy of fetal material...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29740927/are-singleton-pregnancies-after-assisted-reproduction-technology-art-associated-with-a-higher-risk-of-placental-anomalies-compared-with-non-art-singleton-pregnancies-a-systematic-review-and-meta-analysis
#16
REVIEW
B G Vermey, A Buchanan, G M Chambers, E M Kolibianakis, J Bosdou, M G Chapman, C A Venetis
BACKGROUND: Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (ART). OBJECTIVES: To determine whether ART singleton pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies...
May 8, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29734439/optimization-of-human-semen-extender-components-for-cryopreservation-using-statistical-tools
#17
P M Ramesh, A S Vickram, T B Sridharan, R Parameswari, K Archana, S Nithya, A Mishika
  BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART). OBJECTIVE: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa. MATERIALS AND METHODS: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method...
November 2017: Cryo Letters
https://www.readbyqxmd.com/read/29731504/application-of-auxin-inducible-degron-technology-to-mouse-oocyte-activation-with-plc%C3%AE
#18
Kento Miura, Shogo Matoba, Narumi Ogonuki, Takafumi Namiki, Junya Ito, Naomi Kashiwazaki, Atsuo Ogura
In mammals, spermatozoa activate oocytes by triggering a series of intracellular Ca2+ oscillations with phospholipase C zeta (PLCζ), a sperm-borne oocyte-activating factor. Because the introduction of PLCζ alone can induce oocyte activation, it might be a promising reagent for assisted reproductive technologies. To test this possibility, we injected human PLCζ (hPLCζ) mRNA into mouse oocytes at different concentrations. We observed the oocyte activation and subsequent embryonic development. Efficient oocyte activation and embryonic development to the blastocyst stage was achieved only with a limited range of mRNA concentrations (0...
May 5, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29731240/predicting-live-birth-for-poor-ovarian-responders-the-prosper-concept
#19
Philippe Lehert, Wai Chin, Joan Schertz, Thomas D'Hooghe, Carlo Alviggi, Peter Humaidan
RESEARCH QUESTION: A number of live-birth predictive models are available, and despite clinical interest these are rarely used owing to poor performance. In addition, no predictive models specifically for poor ovarian responders (POR) are available. The aim of the current project was to develop a clinically applicable tool for predicting live birth for PORs receiving recombinant human FSH [r-hFSH]. DESIGN: A model was developed to predict live birth in PORs receiving r-hFSH, using data from the ESPART trial...
March 29, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29731212/no-292-abnormal-uterine-bleeding-in-pre-menopausal-women
#20
Sukhbir Singh, Carolyn Best, Sheila Dunn, Nicholas Leyland, Wendy Lynn Wolfman
BACKGROUND: Abnormal uterine bleeding is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for this problem during their reproductive years. This guideline replaces previous clinical guidelines on the topic and is aimed to enable health care providers with the tools to provide the latest evidence-based care in the diagnosis and the medical and surgical management of this common problem...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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