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https://www.readbyqxmd.com/read/28926719/exosomes-derived-from-embryonic-stem-cells-inhibit-doxorubicin-and-inflammation-induced-pyroptosis-in-muscle-cells
#1
Zahra Tavakoli Dargani, Reetu Singla, Taylor Johnson, Rakesh C Kukreja, Dinender Kumar Singla
Doxorubicin (Dox) is an effective anticancer drug. Unfortunately, it causes cardio and muscle toxicity due to increased oxidative stress and inflammation; however, it remains unknown whether Dox induces "pyroptosis"- an inflammation mediated cell death. We investigated whether Dox induces pyroptosis in mouse soleus muscle (Sol 8) cells in vitro and to show the protective effect of embryonic stem cells-exosomes (ES-exos) on pyroptosis. Doxorubicin and inflammation induced in vitro model was generated. Pyroptosis was confirmed using immunohistochemistry and western blotting of putative markers caspase-1, IL1β and pro-inflammatory cytokine IL-18...
September 19, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28925865/structural-changes-of-human-serum-albumin-hsa-in-simulated-microgravity
#2
Azadeh Hekmat, Zahra Hajebrahimi, Amir Motamedzade
Nowadays, the biological effects of microgravity have been the subject of various experimental researches. The purpose of this study was to investigate the probable biological effects of microgravity on the human serum albumin (HSA) structure after 3 and 24 h exposure via various spectroscopic instruments. The UV-Visible, near-UV-CD and intrinsic fluorescence spectroscopy represented that microgravity can remarkably change the tertiary structure of HSA. Additionally, the ANS affinity for HSA incremented when the protein was exposed to simulate microgravity compared to unexposed HSA, which may possibly have appeared attributable to expansion of the structure of simulated HSA...
September 17, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28923870/associations-between-voriconazole-therapeutic-drug-monitoring-toxicity-and-outcome-in-liver-transplant-patients-an-observational-study
#3
Zahra Hashemizadeh, Parisa Badiee, Seyed Ali Malekhoseini, Hadi Raeisi Shahraki, Bita Geramizadeh, Hashem Montaseri
The aim of this study was to investigate the variability of voriconazole plasma level and its relationship with clinical outcomes and adverse events, among liver transplant recipients to optimize the efficacy and safety of their treatment. Liver transplant recipients treated with voriconazole were included and voriconazole trough levels were quantified by the validated high-performance liquid chromatography method. Cytochrome P450 genotypes of CYP2C19 were evaluated in allograft liver tissues. A total of 832 voriconazole trough levels from 104 patients were measured...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28921775/what-can-parents-self-report-of-reading-difficulties-tell-us-about-their-children-s-emergent-literacy-at-school-entry
#4
Zahra Esmaeeli, Kjersti Lundetrae, Fiona E Kyle
Research has linked family risk (FR) of reading difficulties (RD) with children's difficulties in emergent literacy development. This study is the first to apply parents' self-report of RD as a proxy for FR in a large sample (n = 1171) in order to test group differences in children's emergent literacy. Emergent literacy, the home literacy environment and children's interest in literacy and letters were compared across different groups of FR children around the school entry. The FR children performed lower in emergent literacy compared with not-FR children...
September 18, 2017: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/28920038/comparing-the-effect-of-preoperative-administration-of-melatonin-and-passiflora-incarnata-on-postoperative-cognitive-disorders-in-adult-patients-undergoing-elective-surgery
#5
Faranak Rokhtabnak, Mohammad Reza Ghodraty, Alireza Kholdebarin, Ali Khatibi, Seyedeh Somayeh Seyed Alizadeh, Zahra Sadat Koleini, Mohammad Mahdi Zamani, Alireza Pournajafian
BACKGROUND: Anxiety is a preoperative complication, which most patients encounter. The use of a premedication to reduce preoperative anxiety with minimal cognitive impairment is crucial. OBJECTIVES: This study was conducted to compare the sedative effect of preoperative melatonin and Passiflora incarnata in patients undergoing elective surgery regarding their potential for postoperative cognitive disorders. METHODS: In this clinical trial, 52 patients American society of anesthesiologists grade (ASA) I and II of both genders were selected to receive either Passiflora incarnata (1000 mg nature made) (n = 26) or melatonin (6 mg) (n = 26) as premedication one hour before surgery...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28919914/agreement-of-clinical-examination-and-ultrasound-methods-for-detection-of-joints-involvements-in-rheumatoid-arthritis
#6
Hadi Karimzadeh, Ramin Rafiei, Zahra Sayedbonakdar, Mehdi Karami
BACKGROUND: Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial tissue inflammation and destruction of articular components which if not controlled properly, can cause disability in patients. For this reason, evaluation of disease activity and its control is very important. In recent years using sonography is promising for the evaluation of disease activity. This study aimed to compare "clinical examination" and "ultrasonography" methods in the detection of disease activity in patients with rheumatoid arthritis...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28919912/the-isfahan-comprehensive-elderly-study-objectives-research-design-methodology-and-preliminary-results
#7
Zahra Heidari, Awat Feizi
BACKGROUND: This paper presents the objectives, research design, methodology, and primary findings of the Isfahan Comprehensive Elderly Study (ICES). MATERIALS AND METHODS: In this cross-sectional study, 603 elderly persons (aged 60 and over) were selected by multistage cluster sampling method from Isfahan, Iran, in 2016 comprehensive questionnaires along with a detailed interview were used to collect information on personal, family, socioeconomic, health and social services characteristics, life styles, physical illnesses and chronic diseases, mental, emotional and cognition disorders, quality of life, disabilities, sleep quality, social supports, life satisfaction, self-efficacy, and of participants...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28919898/chitosan-increases-tomato-root-colonization-by-pochonia-chlamydosporia-and-their-combination-reduces-root-knot-nematode-damage
#8
Nuria Escudero, Federico Lopez-Moya, Zahra Ghahremani, Ernesto A Zavala-Gonzalez, Aurora Alaguero-Cordovilla, Caridad Ros-Ibañez, Alfredo Lacasa, Francisco J Sorribas, Luis V Lopez-Llorca
The use of biological control agents could be a non-chemical alternative for management of Meloidogyne spp. [root-knot nematodes (RKN)], the most damaging plant-parasitic nematodes for horticultural crops worldwide. Pochonia chlamydosporia is a fungal parasite of RKN eggs that can colonize endophytically roots of several cultivated plant species, but in field applications the fungus shows a low persistence and efficiency in RKN management. The combined use of P. chlamydosporia with an enhancer could help its ability to develop in soil and colonize roots, thereby increasing its efficiency against nematodes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28919585/association-of-human-leukocyte-antigens-class-i-and-ii-with-graves-disease-in-iranian-population
#9
Zahra Mehraji, Ali Farazmand, Alireza Esteghamati, Sina Noshad, Maryam Sadr, Somayeh Amirzargar, Mir Saeed Yekaninejad, Aliakbar Amirzargar
BACKGROUND: Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. OBJECTIVE: To identify HLA polymorphisms that might confer susceptibility or protect against GD...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28918704/professionalism-among-multicultural-medical-students-in-the-united-arab-emirates
#10
Mahera Abdulrahman, Shahd Alsalehi, Zahra S M Husain, Satish C Nair, Frederick Robert Carrick
BACKGROUND: Moral competencies and ethical practices of medical professionals are among the desired outcomes of academic training. Unfortunately, academic dishonesty and misconduct are reported from medical colleges across the world. This study investigates the level of academic dishonesty/misconduct among multicultural medical students. OBJECTIVE: The aim of this study is to investigate the level of academic dishonesty/misconduct among multicultural medical students...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28917744/differentiation-of-cumin-seeds-using-a-metal-oxide-based-gas-sensor-array-in-tandem-with-chemometric-tools
#11
Mahdi Ghasemi-Varnamkhasti, Zahra Safari Amiri, Mojtaba Tohidi, Majid Dowlati, Seyed Saeid Mohtasebi, Adenilton C Silva, David D S Fernandes, Mário C U Araujo
Cumin is a plant of the Apiaceae family (umbelliferae) which has been used since ancient times as a medicinal plant and as a spice. The difference in the percentage of aromatic compounds in cumin obtained from different locations has led to differentiation of some species of cumin from other species. The quality and price of cumin vary according to the specie and may be an incentive for the adulteration of high value samples with low quality cultivars. An electronic nose simulates the human olfactory sense by using an array of sensors to distinguish complex smells...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917741/immobilization-of-cytochrome-c-and-its-application-as-electrochemical-biosensors
#12
REVIEW
Zahra Sadat Aghamiri, Mohsen Mohsennia, Hossain-Ali Rafiee-Pour
Cytochrome c (Cyt c) has been used as a model protein to investigate the characters of modified electrodes by many researchers. It has been also employed to construct biosensors to detect hydrogen peroxide, nitrate, superoxide, and etc. Cyt c immobilization techniques, including physical adsorption, entrapment in hydrogel or polymers, layer-by-layer assembly, Langmuir-Blodgett, and covalent attachment are discussed followed by various electrochemical methods applied in the electrode modification. The exploration of some modified protein electrodes, for example, screen printed, microperoxidase and engineered Cyt c are also presented...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917360/a-randomized-controlled-clinical-trial-evaluating-quality-of-life-when-using-a-simple-acupressure-protocol-in-women-with-primary-dysmenorrhea
#13
Fatemeh Bazarganipour, Seyed-Abdolvahab Taghavi, Helen Allan, Nazafarin Hosseini, Ahmad Khosravi, Rahimeh Asadi, Shohreh Salari, Raziyeh Dehghani, Zahra Jamshidi, Marziyeh Rezaei, Mansoreh Saberian, Fatemeh Javedan, Zahra Salari, Fahimeh Miri
OBJECTIVE: To evaluate a simple acupressure protocol in LIV3 and LI4 acupoints in women with primary dysmenorrhea. METHODS: This paper reports a randomized, single blinded clinical trial. 90 young women with dysmenorrhea were recruited to three groups to receive 20min acupressure every day in either LIV3 or LI4, or placebo points. Acupressure was timed five days before menstruation for three successive menstrual cycles. On menstruation, each participant completed the Wong Baker faces pain scale, and the quality of life short form -12 (QOL SF-12)...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916186/clinical-immunological-and-genetic-spectrum-of-696-patients-with-combined-immunode%C3%AF-ciency
#14
Hassan Abolhassani, Janet Chou, Wayne Bainter, Craig Platt, Mahmood Tavassoli, Toba Momen, Marzieh Tavakol, Mohammad Hossein Eslamian, Mohammad Gharagozlou, Masoud Movahedi, Mohsen Ghadami, Amir Ali Hamidieh, Gholamreza Azizi, Reza Yazdani, Mohsen Afarideh, Alireza Ghajar, Arash Havaei, Zahra Chavoushzadeh, Seyed Alireza Mahdaviani, Taher Cheraghi, Nasrin Behniafard, Reza Amin, Soheila Aleyasin, Reza Faridhosseini, Farahzad Jabbari-Azad, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Mahboubeh Mansouri, Mehrnaz Mesdaghi, Delara Babaie, Iraj Mohammadzadeh, Javad Ghaffari, Alireza Shafiei, Najmeddin Kalantari, Hamid Ahanchian, Maryam Khoshkhui, Habib Soheili, Abbas Dabbaghzadeh, Afshin Shirkani, Rasoul Nasiri Kalmarzi, Seyed Hamidreza Mortazavi, Javad Tafaroji, Abbas Khalili, Javad Mohammadi, Babak Negahdari, Mohammad-Taghi Joghataei, Basel K Al-Ramadi, Capucine Picard, Nima Parvaneh, Nima Rezaei, Talal Chatila, Michel J Massaad, Sevgi Keles, Lennart Hammarström, Raif S Geha, Asghar Aghamohammadi
BACKGROUND: Combined immunodeficiencies (CIDs) are diseases of defective adaptive immunity with diverse clinical phenotypes. Although CIDs are more prevalent in the Middle East than Western countries, the resources for genetic diagnosis are limited. OBJECTIVES: This study aims to characterize the categories of CID patients in Iran clinically and genetically. METHODS: Clinical and laboratory data were obtained from 696 patients with CIDs. Patients were subdivided into those with syndromic (344 patients) and non-syndromic CIDs (352 patients)...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#15
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28915069/facilitators-and-barriers-to-positive-airway-pressure-adherence-for-adolescents-a-qualitative-study
#16
Zahra Alebraheem, Alene Toulany, Adele Baker, Jennifer Christian, Indra Narang
RATIONALE: Low adherence to positive airway pressure (PAP) treatment for adolescents with obstructive sleep apnea (OSA) can have long-term cardio-metabolic and developmental impact. OBJECTIVES: To explore the facilitators and barriers to PAP use in adolescents with OSA. METHODS: We conducted a qualitative study using a descriptive thematic analysis approach. A total of 21 interviews were conducted in the clinical setting with adolescents prescribed PAP to treat OSA within the previous 12 months...
September 15, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28913846/cardioprotective-effects-of-pomegranate-punica-granatum-juice-in-patients-with-ischemic-heart-disease
#17
Zahra Razani, Mostafa Dastani, Hamid Reza Kazerani
Ischemic heart disease is the leading cause of mortality worldwide. The purpose of this study was to evaluate the cardioprotective effects of pomegranate juice in patients with ischemic heart disease. One hundred patients, diagnosed with unstable angina or myocardial infarction, were randomly assigned to the test and the control groups (n = 50, each). During 5 days of hospitalization, in addition to the conventional medical therapies, the test groups received 220 mL pomegranate juice, daily. During the hospitalization period, the blood pressure, heart rate, as well as the intensity, occurrence, and duration of the angina were evaluated on a regular basis...
September 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28912941/the-effect-of-er-yag-laser-irradiation-and-different-concentrations-of-sodium-hypochlorite-on-shear-bond-strength-of-composite-to-primary-teeth-s-dentin
#18
Zahra Bahrololoomi, Azam Dadkhah, Mohammadsadegh Alemrajabi
Introduction: The aim of this study was to evaluate the effect of various concentrations of NaOCl on shear bond strength of composite resin to dentin of primary teeth, prepared with laser and bur. Methods: In this in vitro study, 48 primary molars were sectioned at mesiodistal direction and were randomly divided into 6 groups; G1: bur, G2: bur + NaOCl 2.5%, G3: bur + NaOCl 5.25%, G4: laser, G5: laser + NaOCl 2.5%, G6: laser + NaOCl 5.25%. One-Step Plus adhesive was applied after phosphoric acid gel and NaOCl over the dentin surfaces for all groups, and composite resin cylinders were bonded to the samples...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28912666/prevalence-of-low-back-pain-in-iranian-nurses-a-systematic-review-and-meta-analysis
#19
Yosra Azizpour, Ali Delpisheh, Zahra Montazeri, Kourosh Sayehmiri
BACKGROUND: Low back pain (LBP) as a musculoskeletal disorder is one of the most common occupational injuries in nurses but there isn't any valid measure of the prevalence of LBP in Iranian nursing. In order to increase the power and improve the estimates of the prevalence of LBP in Iranian nurses, a comprehensive meta-analysis was carried out. A summary measure of all studies conducted in this field was found and distributions of LBP were evaluated based on different variables. METHODS: Inclusion criteria included articles with prevalence of LBP in Iranian nurses, who had at least six months of work experience without any trauma, injuries to spine, or any underlying disease...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28912589/microbial-diversity-in-the-hypersaline-lake-meyghan-iran
#20
Ali Naghoni, Giti Emtiazi, Mohammad Ali Amoozegar, Mariana Silvia Cretoiu, Lucas J Stal, Zahra Etemadifar, Seyed Abolhassan Shahzadeh Fazeli, Henk Bolhuis
Lake Meyghan is one of the largest and commercially most important salt lakes in Iran. Despite its inland location and high altitude, Lake Meyghan has a thalassohaline salt composition suggesting a marine origin. Inputs of fresh water by rivers and rainfall formed various basins characterized by different salinities. We analyzed the microbial community composition of three basins by isolation and culturing of microorganisms and by analysis of the metagenome. The basins that were investigated comprised a green ~50 g kg(-1) salinity brine, a red ~180 g kg(-1) salinity brine and a white ~300 g kg(-1) salinity brine...
September 14, 2017: Scientific Reports
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