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https://www.readbyqxmd.com/read/28226536/evaluation-of-a-novel-portable-micro-pump-and-infusion-system-for-drug-delivery
#1
Paul Pankhurst, Zahra McGuinness Abdollahi, Paul Pankhurst, Zahra McGuinness Abdollahi, Zahra McGuinness Abdollahi, Paul Pankhurst
In this paper the design, fabrication and experimental results of a novel portable fixed-displacement micro-pump for controlled dosing and timing is described. The new pump is developed especially for high efficiency, high accuracy, ease of use and very low cost for single use drug delivery systems which can overcome many of the deficiencies of current portable pumps. Primary tests have been conducted and the results have demonstrated that the pump has the ability to deliver high performance and accuracy with less than +/-1% error over the whole operating flow rate range of 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224489/application-of-hidden-markov-models-in-biomolecular-simulations
#2
Saurabh Shukla, Zahra Shamsi, Alexander S Moffett, Balaji Selvam, Diwakar Shukla
Hidden Markov models (HMMs) provide a framework to analyze large trajectories of biomolecular simulation datasets. HMMs decompose the conformational space of a biological molecule into finite number of states that interconvert among each other with certain rates. HMMs simplify long timescale trajectories for human comprehension, and allow comparison of simulations with experimental data. In this chapter, we provide an overview of building HMMs for analyzing bimolecular simulation datasets. We demonstrate the procedure for building a Hidden Markov model for Met-enkephalin peptide simulation dataset and compare the timescales of the process...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28224386/%C3%AE-bisabolol-inhibits-aspergillus-fumigatus-af239-growth-via-affecting-microsomal-%C3%A2-24-sterol-methyltransferase-as-a-crucial-enzyme-in-ergosterol-biosynthesis-pathway
#3
Zahra Jahanshiri, Masoomeh Shams-Ghahfarokhi, Farnoush Asghari-Paskiabi, Reza Saghiri, Mehdi Razzaghi-Abyaneh
Finding new compounds with antifungal properties is an important task due to the side effects of common antifungal drugs and emerging antifungal resistance in fungal strains. ∆(24)-sterol methyltransferase (24-SMT) is a crucial enzyme that plays important roles in fungal ergosterol biosynthesis pathway and is not found in humans. In the present study, the effects of α-bisabolol on Aspergillus fumigatus Af239 growth and ergosterol synthesis on the base of 24-SMT enzyme activity were studied; in addition, the expression of erg6, the gene encoded 24-SMT, was considered...
March 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28223030/heterologous-expression-of-a-rice-metallothionein-isoform-osmti-1b-in-saccharomyces-cerevisiae-enhances-cadmium-hydrogen-peroxide-and-ethanol-tolerance
#4
Zahra Ansarypour, Azar Shahpiri
Metallothioneins are a superfamily of low-molecular-weight, cysteine (Cys)-rich proteins that are believed to play important roles in protection against metal toxicity and oxidative stress. The main purpose of this study was to investigate the effect of heterologous expression of a rice metallothionein isoform (OsMTI-1b) on the tolerance of Saccharomyces cerevisiae to Cd(2+), H2O2 and ethanol stress. The gene encoding OsMTI-1b was cloned into p426GPD as a yeast expression vector. The new construct was transformed to competent cells of S...
February 4, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28222501/a-molecular-case-control-study-of-association-of-hnf1a-gene-polymorphisms-rs2259816-and-rs7310409-with-risk-of-coronary-artery-disease-in-iranian-patients
#5
Samaneh Adami Barzi, Sayyed Mohammad Hossein Ghaderian, Zahra Noormohammadi
BACKGROUND: Coronary artery disease (CAD) is the one of the most common heart diseases, being the main factor of mortality and morbidity worldwide. CAD has been known as a multifactorial disease and its progression depends on genetic and environmental factors. Numerous studies have shown evidence for association between 12q24.3 locus and CAD. OBJECTIVES: In the present study, the association of two HNF1A polymorphisms, rs2259816 and rs7310409, located on 12q24.3 locus with CAD was investigated in Iranian patients...
January 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28220295/dnmt3b-579-g-t-promoter-polymorphism-and-the-risk-of-gastric-cancer-in-the-west-of-iran
#6
Kulsom Ahmadi, Azam Soleimani, Shiva Irani, Aliasghar Kiani, Kourosh Ghanadi, Zahra Noormohamadi, Foroozan Sakinejad
BACKGROUND: Many studies have suggested that modulation of DNMT3B function caused by single nucleotide polymorphisms of the DNMT3B promoter region may underlie the susceptibility to various cancers such as tumors of the digestive system. The aim of this study was to investigate the effect of -579 G>T polymorphism in the promoter of the DNMT3B gene on risk of gastric cancer in a population from West Iran. PATIENTS AND METHODS: We conducted a case-control study in 100 gastric cancer patients and 112 cancer-free controls to assess the correlation between DNMT3B -579 G>T (rs1569686) polymorphism and the risk of gastric cancer...
February 21, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28218564/-a-brief-of-gestational-diabetes-mellitus-risk-factors-and-current-criteria-of-diagnosis
#7
Zahra Al-Aissa, Orsolya Hadarits, Klára Rosta, András Zóka, János Rigó, Gábor Firneisz, Anikó Somogyi
Diabetes is one of the most common metabolic disorders that may cause pathological pregnancy. Treating diabetes recognized during pregnancy results in lowering maternal and fetal complications. These patients present higher risk for excessive weight gain, preeclampsia, delivery with cesarean sections, high risk of developing type 2 diabetes and cardiovascular disease in the future. Fetuses of mothers with gestational diabetes are at higher risk for macrosomia and birth trauma, after delivery they present higher risk of developing neonatal hypoglycemia, hyperbilirubinemia, and respiratory distress syndrome...
February 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28217651/differential-immune-reactivity-pattern-of-sw48-and-sw1116-colorectal-cancer-cell-lines-with-colorectal-cancer-patients-sera
#8
Ghasem Ghalamfarsa, Seyyed Vahid Hosseini, Maryam Hamidinia, Abbas Ghaderi, Mahmoud Mahmoudi, Zahra Mojtahedi
BACKGROUND: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. It is also known as the second leading cause of deaths as the early stage detection is not yet available by current methods. So identification of biomarkers can also be functional in early diagnosis and prognosis. MATERIALS AND METHODS: We examined sera from 60 CRC patients of different stages as a source of auto-antibody as well as two human CRC cell lines with different invasive capacities (SW48 and SW1116) as the source of antigens...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217648/psychological-and-familial-factors-of-depression-in-relation-to-adolescent-smoking-behavior
#9
Hamidreza Roohafza, Razieh Omidi, Tahereh Alinia, Kamal Heidari, Marziyeh Farshad, Hossein Davari, Zahra Abtin, Ezat Shahriari, Mahshid Taslimi, Masoumeh Sadeghi
BACKGROUND: Several common factors have been identified for smoking and depression. The The present study explores the relation of psychological and familial factors with depression, by student smoking behavior. MATERIALS AND METHODS: A total of 5500 middle- and high-school students were selected in Isfahan province in 2010. A self-administered questionnaire collected data on background characteristics, smoking status, depression, and risk factors. Univariate analysis multiple logistic regressions were conducted to compare between depressed and nondepressed people by adolescent smoking status...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217647/wound-healing-effect-of-arnebia-euchroma-gel-on-excisional-wounds-in-rats
#10
Maryam Mohsenikia, Shahrzad Khakpour, Zahra Azizian, Soheil Ashkani-Esfahani, Seyyede Tahereh Razavipour, Pooya Toghiani
BACKGROUND: Wound healing is a complex process leading to regeneration of damaged skin tissue. Arnebia euchroma (AE) have many effective activities such as anti-inflammatory, antimicrobial, antioxidative, and anti-tumoral effects. The extract of AE has positive effects on burn wounds. This study is designed to investigate the healing effects of AE on excisional wounds in rats. MATERIALS AND METHODS: Thirty six rats with the age of 8 weeks divided into three groups...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217258/antioxidant-effects-of-aqueous-extract-of-salep-on-paraquat-induced-rat-liver-injury
#11
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Sanaz Zarei
AIM: To evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODS: In this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experimental groups, Paraquat alone and with different doses of Salep aqueous extract (40, 80, 160 and 320 mg/kg) was given intraperitoneal daily for 14 d...
February 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28216037/esr1-single-nucleotide-polymorphism-rs1062577-c-3804t-a-alters-the-susceptibility-of-breast-cancer-risk-in-iranian-population
#12
Zahra Dehghan, Samira Sadeghi, Hossein Tabatabaeian, Kamran Ghaedi, Mansoureh Azadeh, Mohammad Fazilati, Fatemeh Bagheri
OBJECTIVES: Albeit single nucleotide polymorphisms related to ESR1 gene have been studied, only a number of them have been reported to be associated with breast cancer risk. rs1062577 is one of the most recent microRNA-related ESR1 SNPs; however, no study has been conducted to investigate the significance this polymorphism in Iranian population. In this study, we aimed to investigate the frequency and also the association between rs1062577 and breast cancer. MATERIALS AND METHODS: rs1062577 position was genotyped by Tetra-primer ARMS-PCR in totally 182 blood specimens obtained from breast cancer patients (n=86), and healthy blood donors (n=96)...
February 16, 2017: Gene
https://www.readbyqxmd.com/read/28215564/expression-analysis-and-atr-ftir-characterization-of-the-secondary-structure-of-recombinant-human-tnf-%C3%AE-from-escherichia-coli-shuffle-%C3%A2-t7-express-and-bl21-de3-cells
#13
Hossein Safarpour, Sahar Barzegari Banadkoki, Zahra Keshavarzi, Mohammad Hossein Morowvat, Mahdieh Soleimanpour, Shokoufeh Pourmolaei, Farshad H Shirazi
TNF-α, a prototype member of the TNF family of ligands, has both pro-inflammatory and immune-regulatory functions, which make it as an appropriate therapeutic target for selective blockade in antibody therapy of many diseases like in rheumatoid arthritis. Using two models of SHuffle(®) T7 Express and BL21 (DE3) cells, we have expressed this protein and recognized it by SDS-PAGE analysis. FTIR biospectroscopy of the resulted purified proteins has been performed and mathematical calculations has been done for further identification of the structural and conformational differences between the two products...
February 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28215401/nickel-salen-supported-paramagnetic-nanoparticles-for-6-his-target-recombinant-protein-affinity-purification
#14
Zahra Rashid, Ramin Ghahremanzadeh, Mohammad-Reza Nejadmoghaddam, Mahboobeh Nazari, Mohammad-Reza Shokri, Hossein Naeimi, Amir-Hassan Zarnani
In this research, a simple, efficient, inexpensive, rapid and high yield method for the purification of 6×histidine-tagged recombinant protein was developed. For this purpose, manganese ferrite magnetic nanoparticles (MNPs) were synthesized through a co-precipitation method and then they were conveniently surface-modified with tetraethyl orthosilicate (TEOS) in order to prevent oxidation and form high density of hydroxyl groups. Next, the salen ligand was prepared from condensation reaction of salicylaldehyde and 3-aminopropyl (trimethoxy) silane (APTMS) in 1:1 molar ratio; followed by complexation with Ni(OAc)2...
February 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28215176/the-comparison-the-serum-strem1-levels-between-children-with-upper-and-lower-uti
#15
Samileh Noorbakhsh, Fahime Ehsanipour, Vida Zarabi, Zahra Movahedi, Nahid Rahimzadeh
: Back ground: UTI is a common and important clinical problem in Iranian children which is often difficult on clinical grounds. Distinguishing the upper UTI from lower UTI is very important for clinician. The aim of this study was to determine the usefulness of serum STREM-1 level in patients with UTI to find out if it can use for distinguishing upper UTI from lower UTI or not. METHODS: In this prospective cross sectional study (2010-2011) we compared the serum level of STREM-1 (pg...
February 16, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28215156/medicinal-plants-targeting-cardiovascular-diseases-in-view-of-avicenna
#16
Zahra Sobhani, Saeed Reza Nami, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Cardiovascular disease (CVD) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. Medicinal plants have been used for thousands of years to treat CVD. In Traditional Persian Medicine (TPM), there is a special focus on heart diseases. Avicenna, a Persian physician of the eleventh century compiled a book devoted to this field named "The treatise on cardiac drugs" which is a compendium of TPM knowledge on CVD. Avicenna mentioned 50 cardiovascular active plants and described their therapeutic effects in the treatment of CVDs...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28214926/role-of-serum-level-and-genetic-variation-of-il-28b-in-interferon-responsiveness-and-advanced-liver-disease-in-chronic-hepatitis-c-patients
#17
Abdolvahab Alborzi, Tayebeh Hashempour, Javad Moayedi, Zahra Musavi, Gholamreza Pouladfar, Shahin Merat
Interleukin-28B (IL-28B) is suspected to be associated with response to treatment and one of the basic immunological backgrounds in liver transplant candidate (LTC). We aimed to assess whether genotypes of IL-28B can play a role in therapeutic response or advanced stages of liver disease. A total of 364 subjects were genotyped for IL-28B rs12979860 and rs8099917 SNPs using PCR-RFLP assay. Moreover, IL-28 serum level, HCV loads, and genotype were performed. A significant increase was observed in the frequencies of unfavorable rs12979860 genotypes/CT + TT in the chronic hepatitis C (CHC) and LTC groups...
February 18, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28214066/identification-of-g-170g-a-and-g-332g-a-mutations-in-exon-3-of-leptin-gene-bcnl-and-cail-and-their-association-with-semen-quality-and-testicular-dimensions-in-sanjabi-rams
#18
Roya Bakhtiar, Alireza Abdolmohammadi, Hadi Hajarian, Zahra Nikousefat, Davood Kalantar-Neyestanaki
The purpose of this study was to investigate leptin gene polymorphisms and their relationships with the characteristics of sperm quality and testicular dimensions. Semen samples were collected from 96 Sanjabi rams during autumn and spring seasons over two years. Simultaneously, the dimensions of length, width and scrotal circumference were measured. Blood samples were taken from the jugular vein to extract DNA. PCR was performed to amplify a 463bp fragment including exon 3 of leptin gene. PCR products were digested by Bcnl and Cail restriction enzymes to identify 170G>A and 332G>A mutations in exon 3, respectively...
February 4, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28212650/skin-cancer-knowledge-and-attitudes-in-the-region-of-fez-morocco-a-cross-sectional-study
#19
Awatef Kelati, Hanane Baybay, Mariam Atassi, Samira Elfakir, Salim Gallouj, Mariame Meziane, Fatima Zahra Mernissi
BACKGROUND: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco. METHODS: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014)...
February 17, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28212423/phenolic-extract-from-oleaster-olea-europaea-var-sylvestris-leaves-reduces-colon-cancer-growth-and-induces-caspase-dependent-apoptosis-in-colon-cancer-cells-via-the-mitochondrial-apoptotic-pathway
#20
Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz Hichami
Dietary polyphenols, derived from natural products, have received a great interest for their chemopreventive properties against cancer. In this study, we investigated the effects of phenolic extract of the oleaster leaves (PEOL) on tumor growth in mouse model and on cell death in colon cancer cell lines. We assessed the effect of oleaster leaf infusion on HCT116 (human colon cancer cell line) xenograft growth in athymic nude mice. We observed that oleaster leaf polyphenol-rich infusion limited HCT116 tumor growth in vivo...
2017: PloS One
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