keyword
https://read.qxmd.com/read/38535600/the-re-emergence-of-rift-valley-fever-in-mananjary-district-madagascar-in-2021-a-call-for-action
#1
JOURNAL ARTICLE
Aina Nirina Harimanana, Soa Fy Andriamandimby, Dany Bakoly Ranoaritiana, Laurence Randrianasolo, Judickaelle Irinantenaina, Nirina Nantenaina Ranoelison, Jean Théophile Rafisandrantatsoa, Miamina Fidy Ankasitrahana, Antso Hasina Raherinandrasana, Manuela Vololoniaina Andriamahatana, Michael Luciano Tantely, Romain Girod, Philippe Dussart, Vincent Lacoste, Rindra Vatosoa Randremanana
An epizootic of rift valley fever (RVF) was suspected on 21 February 2021 in various districts of Madagascar, with a lab confirmation on 1 April 2021. A cross-sectional survey aiming to detect cases of RVF in humans and to study the circulation of rift valley fever virus (RVFV) in animals was conducted from 22 April to 4 May 2021 in the district of Mananjary. Blood samples from cattle and humans were tested using serological and molecular techniques. In cattle, the circulation of RVFV was confirmed between 5 February and 4 May 2021...
March 16, 2024: Pathogens
https://read.qxmd.com/read/38535257/the-potential-teeth-bleaching-and-halitosis-prevention-effects-of-pediococcus-inopinatus-thk-30-a-kimchi-derived-lactic-acid-bacterium-in-vitro-study
#2
JOURNAL ARTICLE
Trang Thi Minh Nguyen, Qiwen Zheng, Eun-Ji Yi, Arce Defeo Bellere, Xiangji Jin, Hong-Yong Kim, Tae-Hoo Yi
BACKGROUND: Recent developments in addressing dental aesthetic concerns, encompassing issues like teeth discoloration and halitosis, underscore the demand for safer alternative solutions. PURPOSE: This study aims to confirm the effects of lactic acid bacteria (LAB) from kimchi on artificial teeth bleaching and their potential impact in terms of preventing halitosis-related bacteria. MATERIALS AND METHODS: To evaluate the antimicrobial effects against oral pathogens, disc diffusion tests and broth microdilution methods were used...
March 7, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534801/the-efficacy-of-a-multimodal-bedroom-based-smart-alarm-system-on-mitigating-the-effects-of-sleep-inertia
#3
JOURNAL ARTICLE
Carolina Campanella, Kunjoon Byun, Araliya Senerat, Linhao Li, Rongpeng Zhang, Sara Aristizabal, Paige Porter, Brent Bauer
Previous work has demonstrated the modest impact of environmental interventions that manipulate lighting, sound, or temperature on sleep inertia symptoms. The current study sought to expand on previous work and measure the impact of a multimodal intervention that collectively manipulated light, sound, and ambient temperature on sleep inertia. Participants slept in the lab for four nights and were awoken each morning by either a traditional alarm clock or the multimodal intervention. Feelings of sleep inertia were measured each morning through Psychomotor Vigilance Test (PVT) assessments and ratings of sleepiness and mood at five time-points...
March 18, 2024: Clocks & Sleep
https://read.qxmd.com/read/38534635/synergistic-activity-of-ingulados-bacteria-with-antibiotics-against-multidrug-resistant-pathogens
#4
JOURNAL ARTICLE
Javier Blanco-Blanco, María Bravo, Irene Simón, Pedro Fernández-Llario, Miguel Fajardo-Olivares, María Coronada Fernández-Calderón, Rosario Cerrato
Antimicrobial resistance is a critical challenge due to the overuse of conventional antimicrobials, and alternative solutions are urgently needed. This study investigates the efficacy of compounds derived from lactic acid bacteria (LAB) fermentation combined with antibiotics against multidrug-resistant pathogens isolated from clinical cases in a hospital setting. Strains of Escherichia coli , Klebsiella pneumoniae , and Enterococcus faecium and faecalis were isolated and selected from blood, respiratory, and urine samples...
February 20, 2024: Antibiotics
https://read.qxmd.com/read/38534554/the-effect-of-a-new-generation-of-ankle-foot-orthoses-on-sloped-walking-in-children-with-hemiplegia-using-the-gait-real-time-analysis-interactive-lab-grail
#5
JOURNAL ARTICLE
Federica Camuncoli, Giorgia Malerba, Emilia Biffi, Eleonora Diella, Eugenio Di Stanislao, Guerrino Rosellini, Daniele Panzeri, Luigi Piccinini, Manuela Galli
Cerebral palsy poses challenges in walking, necessitating ankle foot orthoses (AFOs) for stability. Gait analysis, particularly on slopes, is crucial for effective AFO assessment. The study aimed to compare the performance of commercially available AFOs with a new sports-specific AFO in children with hemiplegic cerebral palsy and to assess the effects of varying slopes on gait. Eighteen participants, aged 6-11, with hemiplegia, underwent gait analysis using GRAIL technology. Two AFO types were tested on slopes (uphill +10 deg, downhill -5 deg, level-ground)...
March 16, 2024: Bioengineering
https://read.qxmd.com/read/38534523/profile-of-a-multivariate-observation-under-destructive-sampling-a-monte-carlo-approach-to-a-case-of-spina-bifida
#6
JOURNAL ARTICLE
Tianyuan Guan, Rigwed Tatu, Koffi Wima, Marc Oria, Jose L Peiro, Chia-Ying Lin, Marepalli B Rao
A biodegradable hybrid polymer patch was invented at the University of Cincinnati to cover gaps on the skin over the spinal column of a growing fetus, characterized by the medical condition spina bifida. The inserted patch faces amniotic fluid (AF) on one side and cerebrospinal fluid on the other side. The goal is to provide a profile of the roughness of a patch over time at 0, 4, 8, 12, and 16 weeks with a 95% confidence band. The patch is soaked in a test tube filled with either amniotic fluid (AF) or phosphate-buffered saline (PBS) in the lab...
March 3, 2024: Bioengineering
https://read.qxmd.com/read/38534259/customizable-nichrome-wire-heaters-for-molecular-diagnostic-applications
#7
JOURNAL ARTICLE
Juhee Lim, Won Han, Le Tran Huy Thang, Yong Wook Lee, Joong Ho Shin
Accurate sample heating is vital for nucleic acid extraction and amplification, requiring a sophisticated thermal cycling process in nucleic acid detection. Traditional molecular detection systems with heating capability are bulky, expensive, and primarily designed for lab settings. Consequently, their use is limited where lab systems are unavailable. This study introduces a technique for performing the heating process required in molecular diagnostics applicable for point-of-care testing (POCT), by presenting a method for crafting customized heaters using freely patterned nichrome (NiCr) wire...
March 20, 2024: Biosensors
https://read.qxmd.com/read/38534222/real-time-on-site-monitoring-of-viruses-in-wastewater-using-nanotrap-%C3%A2-particles-and-ricca-technologies
#8
JOURNAL ARTICLE
Vishnu Sharma, Hitomi Takamura, Manish Biyani, Ryo Honda
Wastewater-based epidemiology (WBE) is an effective and efficient tool for the early detection of infectious disease outbreaks in a community. However, currently available methods are laborious, costly, and time-consuming due to the low concentration of viruses and the presence of matrix chemicals in wastewater that may interfere with molecular analyses. In the present study, we designed a highly sensitive "Quick Poop (wastewater with fecal waste) Sensor" (termed, QPsor) using a joint approach of Nanotrap microbiome particles and RICCA (RNA Isothermal Co-Assisted and Coupled Amplification)...
February 21, 2024: Biosensors
https://read.qxmd.com/read/38533825/the-effect-of-an-electronic-medical-record-based-clinical-decision-support-system-on-adherence-to-clinical-protocols-in-inflammatory-bowel-disease-care-interrupted-time-series-study
#9
JOURNAL ARTICLE
Reed Taylor Sutton, Kaitlyn Delaney Chappell, David Pincock, Daniel Sadowski, Daniel C Baumgart, Karen Ivy Kroeker
BACKGROUND: Clinical decision support systems (CDSSs) embedded in electronic medical records (EMRs), also called electronic health records, have the potential to improve the adoption of clinical guidelines. The University of Alberta Inflammatory Bowel Disease (IBD) Group developed a CDSS for patients with IBD who might be experiencing disease flare and deployed it within a clinical information system in 2 continuous time periods. OBJECTIVE: This study aims to evaluate the impact of the IBD CDSS on the adherence of health care providers (ie, physicians and nurses) to institutionally agreed clinical management protocols...
March 22, 2024: JMIR Medical Informatics
https://read.qxmd.com/read/38533822/vascularized-tissue-on-mesh-assisted-platform-vt-map-a-novel-approach-for-diverse-organoid-size-culture-and-tailored-cancer-drug-response-analysis
#10
JOURNAL ARTICLE
Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li Jeon
This study presents the vascularized tissue on mesh-assisted platform (VT-MAP), a novel microfluidic in vitro model that uses an open microfluidic principle for cultivating vascularized organoids. Addressing the gap in 3D high-throughput platforms for drug response analysis, the VT-MAP can host tumor clusters of various sizes, allowing for precise, size-dependent drug interaction assessments. Key features include capability for forming versatile co-culture conditions (EC, fibroblasts and colon cancer organoids) that enhance tumor organoid viability and a perfusable vessel network that ensures efficient drug delivery and maintenance of organoid health...
March 27, 2024: Lab on a Chip
https://read.qxmd.com/read/38531916/simultaneous-impregnation-and-microencapsulation-of-cacl-2-using-silica-gel-and-methyl-cellulose-for-thermal-energy-storage-applications
#11
JOURNAL ARTICLE
Suboohi Shervani, Curtis Strong, F Handan Tezel
Thermal energy storage utilizing the adsorption of moisture from air is a promising energy storage technology due to its high energy density and minimum heat losses. Salt hydrates and salt hydrate composites, such as calcium chloride (CaCl2 ) and CaCl2 -based composites, have shown favourable energy storage properties in this area of research. However, these materials have shown issues with stability due to swelling and deliquescence. In this work, CaCl2 was stabilized using three methods: impregnation into silica gel, encapsulation in methyl cellulose, and both impregnation and encapsulation stabilization techniques used simultaneously...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531237/validation-of-an-on-farm-portable-blood-analyzer-for-quantifying-blood-analytes-in-dairy-cows
#12
JOURNAL ARTICLE
Sophia J Kendall, Sophia E Green, Sophia M Edwards, Garrett R Oetzel, Heather M White
The periparturient period for dairy cows is a metabolically dynamic time period where the cow is adjusting from gestation to the onset of lactation. Metabolic disorders such as ketosis, hypocalcemia, and fatty liver occur during this time; however, tools to diagnose these diseases on-farm is limited. The need for compact metabolite quantification devices that can quantify metabolites on farm from whole blood samples is warranted. The purpose of this study was to validate a portable blood analyzer (PBA) by analyzing metabolites on privately owned dairy farms in southcentral Wisconsin...
March 16, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38531167/clinical-features-polysomnography-and-genetics-association-study-of-restless-legs-syndrome-in-clinic-based-chinese-patients-a-multicenter-observational-study
#13
JOURNAL ARTICLE
Ruiling Liang, Wenjun Zhu, Yinghui Gao, Chen Zhao, Chi Zhang, Liyue Xu, Yuhua Zuo, Yunhui Lv, Mingming Zhao, Chenyu Li, Jie Gao, Junhua Mei, Xue Gong, Lisan Zhang, Shuxia Shen, Chunbin Yang, Jilin Ren, Yan Liu, Zan Wang, Peipei Wang, Jinxia Zhou, Feng Wang, Jun Wu, Juan Chen, Yanmei Zhu, Chunrong Zhang, Xiaosong Dong, Fang Han
STUDY OBJECTIVES: To systemically describe the clinical features, polysomnography (PSG) finding, laboratory tests and single-nucleotide polymorphisms (SNPs) in a clinic based Chinese primary restless legs syndrome (RLS) population. METHODS: This observational study, conducted from January 2020 to October 2021 across 22 sleep labs in China, recruited 771 patients diagnosed with RLS following the 2014 RLSSG criteria. Clinical data, PSG testing, and laboratory examination and SNPs of patients with RLS were collected...
March 21, 2024: Sleep Medicine
https://read.qxmd.com/read/38530558/logistic-regression-and-other-statistical-tools-in-diagnostic-biomarker-studies
#14
JOURNAL ARTICLE
Dina Mohamed Ahmed Samir Elkahwagy, Caroline Joseph Kiriacos
A biomarker is a measured indicator of a variety of processes, and is often used as a clinical tool for the diagnosis of diseases. While the developmental process of biomarkers from lab to clinic is complex, initial exploratory stages often focus on characterizing the potential of biomarkers through utilizing various statistical methods that can be used to assess their discriminatory performance, establish an appropriate cut-off that transforms continuous data to apt binary responses of confirming or excluding a diagnosis, or establish a robust association when tested against confounders...
March 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38530156/standardized-order-set-for-the-management-of-infective-endocarditis
#15
JOURNAL ARTICLE
Kerneisha Murphy, Emily Eiswirth
BACKGROUND: Infective endocarditis (IE) is a potentially life-threatening infection that affects the inner lining of the heart, particularly the heart valves. Patients with preexisting heart conditions, damaged heart valves, or a history of intravenous drug use are at a higher risk of acquiring IE. LOCAL PROBLEM: A rural acute care facility reported that 68.75% of patients who had a methicillin-resistant Staphylococcus aureus infection were diagnosed with IE. Review of medical records showed that 65% of patients with IE did not have antibiotic start/stop dates and 51% were discharged before the 6-week completion date...
March 26, 2024: Journal of the American Association of Nurse Practitioners
https://read.qxmd.com/read/38529075/quality-of-answers-of-generative-large-language-models-vs-peer-patients-for-interpreting-lab-test-results-for-lay-patients-evaluation-study
#16
Zhe He, Balu Bhasuran, Qiao Jin, Shubo Tian, Karim Hanna, Cindy Shavor, Lisbeth Garcia Arguello, Patrick Murray, Zhiyong Lu
Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate relevant, accurate, helpful, and unharmful responses to lab test-related questions asked by patients and to identify potential issues that can be mitigated with augmentation approaches. We first collected lab test results related question and answer data from Yahoo! Answers and selected 53 QA pairs for this study...
January 23, 2024: ArXiv
https://read.qxmd.com/read/38528459/positivity-rates-trends-and-experiences-of-health-workers-on-human-papillomavirus-screened-using-genexpert-in-uganda-a-three-year-retrospective-cohort-study
#17
JOURNAL ARTICLE
Harriet Nakigozi, Paul Mukama Ategyeka, Susan Nabadda, Rawlance Ndejjo
INTRODUCTION: Cervical cancer is a major public health issue in Uganda, with high incidence due to limited screening especially in rural areas. In 2019, HPV DNA testing using GeneXpert was rolled out to improve screening access. Assessing progress and challenges since its introduction is important. AIM: To determine genotype distribution and explore health worker experiences with HPV screening using GeneXpert in Uganda. METHODS: We conducted a retrospective cohort study where HPV screening data from 66 GeneXpert labs from March 2021-May 2023 country wide was analyzed...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528030/single-drop-cytometry-onboard-the-international-space-station
#18
JOURNAL ARTICLE
Daniel J Rea, Rachael S Miller, Brian E Crucian, Russell W Valentine, Samantha Cristoforetti, Samuel B Bearg, Zlatko Sipic, Jamie Cheng, Rebecca Yu, Kimesha M Calaway, Dexter Eames, Emily S Nelson, Beth E Lewandowski, Gail P Perusek, Eugene Y Chan
Real-time lab analysis is needed to support clinical decision making and research on human missions to the Moon and Mars. Powerful laboratory instruments, such as flow cytometers, are generally too cumbersome for spaceflight. Here, we show that scant test samples can be measured in microgravity, by a trained astronaut, using a miniature cytometry-based analyzer, the rHEALTH ONE, modified specifically for spaceflight. The base device addresses critical spaceflight requirements including minimal resource utilization and alignment-free optics for surviving rocket launch...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38526818/therapeutic-effects-of-orally-administration-of-viable-and-inactivated-probiotic-strains-against-murine-urinary-tract-infection
#19
REVIEW
Vo Thi Hong Van, Zhen-Shu Liu, Yueh-Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen
Urinary tract infections (UTIs) are highly prevalent bacterial infections that pose significant health risks. Specific probiotic strains have been recommended for UTI control and management of antibiotic resistance. Otherwise, para-probiotics, defined as inactivated probiotic cells, offer potential advantages by minimizing risks associated with live microorganisms. However, the effectiveness of heat-killed probiotic strains against UTIs remains uncertain. Additionally, lactoferrin (LF), an iron-binding glycoprotein, exhibits immunomodulatory, antimicrobial, and anti-inflammatory properties...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526494/development-of-a-follow-up-measure-to-ensure-complete-screening-for-colorectal-cancer
#20
JOURNAL ARTICLE
Elizabeth L Ciemins, Jeff T Mohl, Carlos A Moreno, Francis Colangelo, Robert A Smith, Mary Barton
IMPORTANCE: The current quality performance measure for colorectal cancer (CRC) screening is limited to initial screening. Despite low rates, there is no measure for appropriate follow-up with colonoscopy after receipt of an abnormal result of a stool-based screening test (SBT) for CRC. A quality performance measure is needed. OBJECTIVE: To develop and test a quality performance measure for follow-up colonoscopy within 6 months of an abnormal result of an SBT for CRC...
March 4, 2024: JAMA Network Open
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