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https://www.readbyqxmd.com/read/29215764/an-evaluation-of-the-challenges-to-developing-tumour-brca1-and-brca2-testing-methodologies-for-clinical-practice
#1
Gillian Ellison, Miika Ahdesmäki, Sally Luke, Paul M Waring, Andrew Wallace, Ronnie Wright, Benno Röthlisberger, Katja Ludin, Sabine Merkelbach-Bruse, Carina Heydt, Marjolijn J L Ligtenberg, Arjen R Mensenkamp, David Gonzalez Castro, Thomas Jones, Ana Vivancos, Olga Kondrashova, Patrick Pauwels, Christine Weyn, Eric Hahnen, Jan Hauke, Richie Soong, Zhongwu Lai, Brian Dougherty, T Hedley Carr, Justin Johnson, John Mills, J Carl Barrett
Ovarian cancer patients with germline or somatic pathogenic variants benefit from treatment with PARP inhibitors. Tumour BRCA1/2 testing is more challenging than germline testing as the majority of samples are formalin fixed paraffin embedded (FFPE), the tumour genome is complex and the allelic fraction of somatic variants can be low. We collaborated with 10 laboratories testing BRCA1/2 in tumours to compare different approaches to identify clinically important variants within FFPE tumour DNA samples. This was not a proficiency study but an inter-laboratory comparison to identify common issues...
December 7, 2017: Human Mutation
https://www.readbyqxmd.com/read/29214306/seven-year-weight-trajectories-and-health-outcomes-in-the-longitudinal-assessment-of-bariatric-surgery-labs-study
#2
Anita P Courcoulas, Wendy C King, Steven H Belle, Paul Berk, David R Flum, Luis Garcia, William Gourash, Mary Horlick, James E Mitchell, Alfons Pomp, Walter J Pories, Jonathan Q Purnell, Ashima Singh, Konstantinos Spaniolas, Richard Thirlby, Bruce M Wolfe, Susan Z Yanovski
Importance: More information is needed about the durability of weight loss and health improvements after bariatric surgical procedures. Objective: To examine long-term weight change and health status following Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB). Design, Setting, and Participants: The Longitudinal Assessment of Bariatric Surgery (LABS) study is a multicenter observational cohort study at 10 US hospitals in 6 geographically diverse clinical centers...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29207696/correlation-of-pregnancy-associated-plasma-protein-a-and-zinc-with-calculated-risk-ratio-of-dual-test
#3
Indranil Ghoshal, Bolar Suryakanth Varashree, Vijetha Shenoy Belle, Krishnananda Prabhu
Introduction: First trimester screening by dual test is the most preferred method of antenatal screening. The detection rate of foetal aneuploidy using dual test is 95%. This test uses maternal serum free β human Chorionic Gonadotropin (free β hCG) and Pregnancy Associated Plasma Protein A (PAPP-A) along with maternal demographic and foetal sonographic indices to calculate risk for foetal aneuploidy. PAPP-A is a zinc binding metalloproteinase which is also responsible for placental development and foetal growth...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206205/an-all-glass-microfluidic-network-with-integrated-amorphous-silicon-photosensors-for-on-chip-monitoring-of-enzymatic-biochemical-assay
#4
Francesca Costantini, Roald M Tiggelaar, Riccardo Salvio, Marco Nardecchia, Stefan Schlautmann, Cesare Manetti, Han J G E Gardeniers, Giampiero de Cesare, Domenico Caputo, Augusto Nascetti
A lab-on-chip system, integrating an all-glass microfluidics and on-chip optical detection, was developed and tested. The microfluidic network is etched in a glass substrate, which is then sealed with a glass cover by direct bonding. Thin film amorphous silicon photosensors have been fabricated on the sealed microfluidic substrate preventing the contamination of the micro-channels. The microfluidic network is then made accessible by opening inlets and outlets just prior to the use, ensuring the sterility of the device...
December 5, 2017: Biosensors
https://www.readbyqxmd.com/read/29206109/methodological-considerations-in-the-calculation-of-the-rate-of-force-development-scaling-factor
#5
Dusica Djordjevic, Mehmet Uygur
OBJECTIVE: Within this methodological study, we aimed to explore the effects of seven different commonly applied routines for rate of force development (RFD) calculation on the calculation of rate of force development scaling factor (RFD-SF) and r2 and the between session reliability of RFD-SF in three different muscle groups. APPROACH: We tested grip force muscles, elbow extensors and knee extensors of 13 healthy subjects asking them to produce around 120 rapid isometric force pulses per muscle to varying submaximal amplitudes...
December 5, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29204819/isolation-and-molecular-identification-of-lactic-acid-bacteria-from-king-grass-and-their-application-to-improve-the-fermentation-quality-of-sweet-sorghum
#6
Assar Ali Shah, Yuan Xianjun, Dong Zhihao, Li Junfeng, Tao Shao
The aim of the present study was isolation and molecular identification of lactic acid bacteria from King grass and their application to improve the fermentation quality of sweet Sorghum. Seventy-six strains of LAB were isolated; five strains were selected for Physiological and morphological tests and 16S rRNA sequencing. All five strains grew at different pH 3.5-8.0, different temperature 35, 40, 45, 50 °C and different NaCl concentrations 3, 6.5, 9.5%. Strains HDASK were identified Lactobacillus plantarum and SK3907, SK2A32, SK3A42 and ASKDD Pediococcus acidilactici...
December 4, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29204476/data-documenting-the-performance-of-the-pt-inr-line-correction-method-for-reconciling-inr-discrepancies-between-central-laboratory-coagulation-analyzers-using-different-thromboplastins-during-the-evaluation-of-a-portable-coagulometer
#7
Wendy S Baker, Kathleen J Albright, Heidi Spratt, Megan Berman, Peggy A Mann, Jaime Unabia, John R Petersen
The data presented here was produced as part of an evaluation of the performance of the CoaguChek XS point-of-care coagulation analyzer, which is discussed in the research article "POCT PT INR - Is it adequate for Patient Care? A Comparison of the Roche Coaguchek XS vs. Stago Star vs. Siemens BCS in Patients Routinely Seen in an Anticoagulation Clinic" (Baker et al., in press) [1]. An effort to reconcile discrepancies in the patient INR result distributions from different central lab instruments (Stago Star and Siemens BCS) with the PT/INR line method is described (Poller et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29201369/x-linked-adult-onset-adrenoleukodystrophy-psychiatric-and-neurological-manifestations
#8
Daniah Shamim, Karen Alleyne
Adult-onset adrenoleukodystrophy is a rare x-linked inborn error of metabolism occurring predominantly in males with onset in early 30s. Here, we report a 34-year-old male with first signs of disease in early 20s manifesting as a pure psychiatric disorder. Prior to onset of neurological symptoms, this patient demonstrated a schizophrenia and bipolar-like presentation. The disease progressed over the next 10-13 years and his memory and motor problems became evident around the age of 33 years. Subsequently, diagnostic testing showed the typical magnetic resonance imaging and lab findings for adult-onset adrenoleukodystrophy...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29200602/does-similarity-in-call-structure-or-foraging-ecology-explain-interspecific-information-transfer-in-wild-myotis-bats
#9
Theresa Hügel, Vincent van Meir, Amanda Muñoz-Meneses, B-Markus Clarin, Björn M Siemers, Holger R Goerlitz
Abstract: Animals can gain important information by attending to the signals and cues of other animals in their environment, with acoustic information playing a major role in many taxa. Echolocation call sequences of bats contain information about the identity and behaviour of the sender which is perceptible to close-by receivers. Increasing evidence supports the communicative function of echolocation within species, yet data about its role for interspecific information transfer is scarce...
2017: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29200498/a-teaching-experiment-to-elucidate-a-cation-%C3%AF-effect-in-an-alkyne-cycloaddition-reaction-and-illustrate-hypothesis-driven-design-of-experiments
#10
Elijah J St Germain, Andrew S Horowitz, Dominic Rucco, Evonne M Rezler, Salvatore D Lepore
An organic chemistry experiment is described that is based on recent research to elucidate a novel cation-π interaction between tetraalkammonium cations and propargyl hydrazines. This non-bonded interaction is a key component of the mechanism of ammonium-catalyzed intramolecular cycloaddition of nitrogen to the terminal carbon of a C-C triple bond of the propargyl substrate. In this teaching experiment, reactions and control experiments are employed to demonstrate the testing of two alternative mechanistic hypotheses...
February 14, 2017: Journal of Chemical Education
https://www.readbyqxmd.com/read/29199733/a-robust-portable-and-backflow-free-micromixing-device-based-on-both-capillary-and-vacuum-driven-flows
#11
Yaguang Zhai, Anyang Wang, Domin Koh, Philip Schneider, Kwang W Oh
In capillary- or vacuum-driven microfluidics, surge backflow events are common when merging or pumping two similar or dissimilar liquids together if a pressure difference exists between them. In this work, a robust, portable micromixing device that is insensitive to backflow was designed, fabricated and characterised. A capillary-driven pressure balancing bypass connected between two inlet ports diminished the initial pressure difference caused by capillarity and gravity present in each liquid at the two inlet ports...
December 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29199444/steering-sheath-for-2-nostril-transnasal-office-laryngoscopy
#12
Henry T Hoffman, Helen Stegall, Troy Wingler, Andrew Blitzer
OBJECTIVE: The aim was to study the feasibility of performing office-based laryngeal procedures employing a flexible hollow steerable sheath placed contralateral to the nostril through which a standard flexible video endoscope is placed. METHODS: The study design included simulation of transnasal endoscopic laryngeal procedures evaluating the use of a flexible steering sheath in laboratory and clinic settings. Transnasal laryngeal procedures were performed in an otolaryngology office setting employing an airway-management-trainer mannequin and then repeated in a human cadaver lab with standard transnasal flexible video laryngoscopy...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29199262/impaired-bioenergetics-in-clinical-medicine-a-target-to-tackle
#13
Sergej M Ostojic
Mitochondrial energy deficit is considered a key element of different clinical pathologies - from inherited disorders of energy metabolism to drug-induced mitochondrial toxicity, to cardiometabolic and neurodegenerative diseases. However, clinical manifestations of impaired bioenergetics are not easy to recognize, with patient-reported features usually include non-pathognomonic fatigue and weakness, or exercise intolerance, while specific lab tests are missing. Although it is not clear whether poor energetics is a primary deficit or a secondary consequence of specific disorders, improving mitochondrial viability remains a challenging task in both experimental and clinical medicine...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29198969/validation-of-a-touchscreen-psychomotor-vigilance-task
#14
Lucia Arsintescu, Kenji H Kato, Patrick F Cravalho, Nathan H Feick, Leland S Stone, Erin E Flynn-Evans
OBJECTIVE: The purpose of this study was to compare a psychomotor vigilance task developed for use on touchscreen devices with the original PVT-192 in conditions of acute sleep loss and circadian desynchronization. BACKGROUND: The Psychomotor Vigilance Task (PVT) is considered the gold standard fatigue detection test and is used frequently in fatigue research. With the rapid development of new technologies it is essential to develop a PVT available on different platforms such as touchscreen devices...
November 30, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29198444/endocrine-and-metabolic-assessment-in-adults-with-langerhans-cell-histiocytosis
#15
L Montefusco, S Harari, D Elia, A Rossi, C Specchia, O Torre, G Adda, M Arosio
CONTEXT: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet. OBJECTIVES: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH. METHODS: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism...
November 29, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29198107/fingerprint-analysis-moving-toward-multi-attribute-determination-via-individual-markers
#16
Erica Brunelle, Crystal Huynh, Eden Alin, Morgan Eldridge, Anh Minh Le, Lenka Halámková, Jan Halámek
Forensic science will be forever revolutionized if law enforcement can identify personal attributes of a person of interest solely from a fingerprint. For the past 2 years, the goal of our group was to establish a way to identify originator attributes, specifically biological sex, from a single analyte. To date, an enzymatic assay and two chemical assays have been developed for the analysis of multiple analytes. In this manuscript, two additional assays have been developed. This time, however, the assays utilize only one amino acid each...
December 2, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29196248/coagulation-factor-hyperfunction-after-subarachnoid-hemorrhage-induces-deep-venous-thrombosis
#17
Wang Miao, Ke Zhao, Wenjing Deng, Junfang Teng
OBJECT: To explore the change of coagulation function and associated potential mechanism, the relationship between coagulation disorders and deep venous thrombosis (DVT) after subarachnoid hemorrhage (SAH) within 3 days of onset. METHODS: 150 SAH patients within 3 days of onset and 100 healthy subjects were recruited. Thrombelastography (TEG) analysis and traditional lab tests were performed. Tissue factor (TF), tissue factor pathway inhibitor (TFPI) and activated protein C (APC) were tested by using ELISA kits...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29195452/evaluation-and-calibration-of-mobile-phones-for-noise-monitoring-application
#18
Raphaël Ventura, Vivien Mallet, Valérie Issarny, Pierre-Guillaume Raverdy, Fadwa Rebhi
The increasing number and quality of sensors integrated in mobile phones have paved the way for sensing schemes driven by city dwellers. The sensing quality can drastically depend on the mobile phone, and appropriate calibration strategies are needed. This paper evaluates the quality of noise measurements acquired by a variety of Android phones. The Ambiciti application was developed so as to acquire a larger control over the acquisition process. Pink and narrowband noises were used to evaluate the phones' accuracy at levels ranging from background noise to 90 dB(A) inside the lab...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29190713/operational-evaluation-of-rapid-diagnostic-testing-for-ebola-virus-disease-in-guinean-laboratories
#19
Amanda VanSteelandt, Josephine Aho, Kristyn Franklin, Jacques Likofata, Jean Baptiste Kamgang, Sakoba Keita, Lamine Koivogui, N'Faly Magassouba, Lise D Martel, Anicet George Dahourou
BACKGROUND: Rapid Diagnostic Tests (RDTs) for Ebola Virus Disease (EVD) at the point of care have the potential to increase access and acceptability of EVD testing and the speed of patient isolation and secure burials for suspect cases. A pilot program for EVD RDTs in high risk areas of Guinea was introduced in October 2015. This paper presents concordance data between EVD RDTs and PCR testing in the field as well as an assessment of the acceptability, feasibility, and quality assurance of the RDT program...
2017: PloS One
https://www.readbyqxmd.com/read/29189966/management-of-adverse-renal-events-related-to-alemtuzumab-treatment-in-multiple-sclerosis-a-belgian-consensus
#20
Ben Sprangers, D Decoo, D Dive, A Lysandropoulos, L Vanopdenbosch, C Bovy
Alemtuzumab is a humanized monoclonal antibody indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis with active disease. Multiple sclerosis (MS) patients treated with alemtuzumab are at increased risk for autoimmune adverse events (thyroid disorders, immune thrombocytopenia, and renal disease). The use of alemtuzumab has been associated with the development of renal immune-mediated adverse events in 0.3% of patients in clinical trials in MS, which generally occurred within 39 months of the last administration...
November 30, 2017: Acta Neurologica Belgica
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