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https://www.readbyqxmd.com/read/29678738/autochthonous-lactic-acid-bacteria-isolated-from-pig-faeces-in-thailand-show-probiotic-properties-and-antibacterial-activity-against-enteric-pathogenic-bacteria
#1
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678078/challenges-in-design-and-creation-of-genetic-openehr-archetype
#2
Priscila A Maranhão, Gustavo Bacelar-Silva, Duarte Gonçalves-Ferreira, Pedro Vieira-Marques, Ricardo Cruz-Correia
Since the Human Genomic Project discovered the sequencing of human genome, the interest about genome content in clinical practice has increased. Genetic information has become a key point to understand diseases or improve treatments, for example, the nutrigenomic and nutrigenetics. However, the huge amount of data generated raises the need for Electronic Health Record (EHR) improvements as it becomes increasingly necessary that it includes more specific genetic information. Thus, we aim to propose standard genetic archetypes (in openEHR) and describe our main challenges in this context...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677997/the-perspective-of-nurses-on-nursing-information-system-a-case-study-in-a-developing-country
#3
Masoumeh Sarbaz, Khalil Kimiafar, Elham Nazari
The purpose of this study was to investigate the effect of nursing information system (NIS) on clinical performance from the perspective of nurses in an academic hospital affiliated to Mashhad University of Medical Sciences in Iran. This descriptive cross-sectional study was conducted in 2016. We collected data targeting nurses with over three years' experience in using the NIS (120 nurses). NIS had caused improvement in "accuracy the consistency of drug, lab tests and radiology requests", "increasing the speed of the automated extracting of minimum data set for decision making and care trends" with the means of 4...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677932/risk-prediction-of-diabetic-nephropathy-via-interpretable-feature-extraction-from-ehr-using-convolutional-autoencoder
#4
Takayuki Katsuki, Masaki Ono, Akira Koseki, Michiharu Kudo, Kyoichi Haida, Jun Kuroda, Masaki Makino, Ryosuke Yanagiya, Atsushi Suzuki
This paper describes a technology for predicting the aggravation of diabetic nephropathy from electronic health record (EHR). For the prediction, we used features extracted from event sequence of lab tests in EHR with a stacked convolutional autoencoder which can extract both local and global temporal information. The extracted features can be interpreted as similarities to a small number of typical sequences of lab tests, that may help us to understand the disease courses and to provide detailed health guidance...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677580/effects-of-a-skill-demonstration-video-delivered-by-smartphone-on-facilitating-nursing-students-skill-competencies-and-self-confidence-a-randomized-controlled-trial-study
#5
Yeu-Hui Chuang, Fu-Chih Lai, Chia-Chi Chang, Hsu-Tien Wan
BACKGROUND: The correct and appropriate performance of nursing skills by students can ensure patient safety and care quality. However, developing appropriate teaching and learning strategies to enhance nursing students' nursing skills and knowledge are challenging tasks for nursing faculty members. Nowadays, smartphones are popular mobile devices that are used on campuses by students and could be considered a potential tool to deliver learning materials to nursing students. OBJECTIVES: This study aimed to examine the effects of a skill demonstration video delivered by smartphone on facilitating nursing students' nursing skill competency and confidence...
April 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29674079/a-comparison-study-on-the-use-of-dowex-1-and-teva-resin-in-determination-of-99-tc-in-environmental-and-nuclear-coolant-samples-in-a-sia-system-with-icp-ms-detection
#6
Kamila Kołacińska, Zbigniew Samczyński, Jakub Dudek, Anna Bojanowska-Czajka, Marek Trojanowicz
This work refers to a comparative study of sorbents widely used in determinations of 99 Tc such as TEVA resin and Dowex 1. Despite having a similar functional group of quaternary amines, both materials represent different chromatographic methods-extraction (TEVA resin) and anion exchange (Dowex 1)-which provides a diverse range of their properties significant in determination of 99 Tc in flow conditions. The comparative tests, carried out in a SIA-LOV (Sequential Injection Analysis-Lab-on-Valve) system combined with mass spectrometric (ICP-MS) detection, considered several factors that are crucial from the standpoint of resin´s utility such as sorption capacity, durability, or selectivity, critical in 99 Tc separation from interferences...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673773/the-prevalence-and-cognitive-profile-of-sequence-space-synaesthesia
#7
Jamie Ward, Alberta Ipser, Eva Phanvanova, Paris Brown, Iris Bunte, Julia Simner
People with sequence-space synaesthesia visualize sequential concepts such as numbers and time as an ordered pattern extending through space. Unlike other types of synaesthesia, there is no generally agreed objective method for diagnosing this variant or separating it from potentially related aspects of cognition. We use a recently-developed spatial consistency test together with a novel questionnaire on naïve samples and estimate the prevalence of sequence-space synaesthesia to be around 8.1% (Study 1) to 12...
April 16, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29673750/-extra-facial-lever-granuloma-on-a-herpes-zoster-scar-wolf-s-isotopic-response
#8
E Melgar, J Henry, A Valois, M-B Dubois-Lacour, F Truchetet, B Cribier, J-F Cuny
BACKGROUND: Granuloma faciale (GF), or facial granuloma of Lever, is an uncommon dermatosis occurring classically on the face. We report a case of a GF on zoster scars located on the trunk, which is a highly particular isotopic response. PATIENTS AND METHODS: A 60-year-old man with a sole history of left lumbar zoster presented with a skin lesion present for two months. Clinical examination revealed a 2.5-cm papular erythematous lesion that was both infiltrated and pruritic...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673624/an-efficient-method-to-control-high-mannose-and-core-fucose-levels-in-glycosylated-antibody-production-using-deoxymannojirimycin
#9
Sagit Shalel Levanon, Orit Aharonovitz, Ayelet Maor-Shoshani, Gita Abraham, Dan Kenett, Yehoshua Aloni
Glycosylation on the Fc region of recombinant Immunoglobulin G (IgG) therapeutic antibodies is a critical protein quality attribute which may affect the efficacy and safety of the molecule. During the development of biosimilar therapeutics, adjustment of the glycosylation profile is required in order to match the reference innovator profile. Deoxymannojirimycin (DMJ), a known inhibitor of mannosidase, was used in this study to modulate the glycosylation pattern of antibodies. The effect of DMJ, at concentrations of 5 μM - 500 μM, on non-fucosylated glycoform levels was tested in the biosynthesis processes of two different IgG1 (IgG1 #A and IgG1 #B) using two Chinese hamster ovary (CHO) cell lines (CHO-DXB-11 and CHOK1SV, respectively) in Erlenmeyer flasks and in lab scale bioreactors...
April 16, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29672063/comparing-and-validating-machine-learning-models-for-mycobacterium-tuberculosis-drug-discovery
#10
Thomas Lane, Daniel P Russo, Kimberley M Zorn, Alex Michael Clark, Alexandru Korotcov, Valery Tkachenko, Robert C Reynolds, Alexander Luke Perryman, Joel Stephen Freundlich, Sean Ekins
Tuberculosis is a global health dilemma. In 2016, the WHO reported 10.4 million incidences and 1.7 million deaths. The need to develop new treatments for those infected with Mycobacterium tuberculosis (Mtb) has led to many large-scale phenotypic screens and many thousands of new active compounds identified in vitro. However, with limited funding, efforts to discover new active molecules against Mtb needs to be more efficient. Several computational machine learning approaches have been shown to have good enrichment and hit rates...
April 19, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29671118/application-of-computer-aided-tongue-inspection-for-preliminary-screening-of-esophageal-cancer
#11
Jin-Long Duan, Bo Deng, Guo-Hui Song, Zhi-Feng Chen, Yan-Wei Gong, Yu-Hua He, Li-Qun Jia
OBJECTIVE: To differentiate patients with esophageal cancer or premalignant lesions from the high-risk population for preliminary screening of esophageal cancer using a feature index determined by a computer-aided tongue information acquisition and processing system (DS01-B). METHODS: Totally, 213 patients diagnosed with esophageal cancer or premalignant lesions and 2,840 normal subjects were collected including primarily screened and reexamined, all of them were confirmed with histological examinations...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29667009/encapsulating-viability-of-multi-strain-lactobacilli-as-potential-probiotic-in-pigs
#12
Sudthidol Piyadeatsoontorn, Rutjawate Taharnklaew, Tewa Upathanpreecha, Pairat Sornplang
Important aspects of the selection of probiotics to be used for mixing in animal feed include host species specificity and probiotic cell survival during production and storage of their products. The research was to screen and investigate some probiotic properties of lactic acid bacteria (LAB) isolated from pig fecal samples. One hundred and thirty-eight representative LAB isolates, which were isolated from 51 pig fecal samples, were tested for acid and bile tolerance, antimicrobial susceptibility, antibacterial activity, potential adhesion to the cell surface, and survival rates when stored in varied microencapsulation forms: freeze-dried, spray-dried, and micro-beads...
April 17, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29666620/the-impact-of-the-antimicrobial-compounds-produced-by-lactic-acid-bacteria-on-the-growth-performance-of-mycobacterium-avium-subsp-paratuberculosis
#13
Petr Kralik, Vladimir Babak, Radka Dziedzinska
Cell-free supernatants (CFSs) extracted from various lactic acid bacteria (LAB) cultures were applied to Mycobacterium avium subsp. paratuberculosis (MAP) cells to determine their effect on MAP viability. In addition, 5% lactic acid (LA; pH 3) and commercially synthetized nisin bacteriocin were also tested. This procedure was chosen in order to mimic the influence of LAB compounds during the production and storage of fermented milk products, which can be contaminated by MAP. Its presence in milk and milk products is of public concern due to the possible ingestion of MAP by consumers and the discussed role of MAP in Crohn's disease...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29664347/which-melodic-universals-emerge-from-repeated-signaling-games-a-note-on-lumaca-and-baggio-2017-%C3%A2
#14
Andrea Ravignani, Tessa Verhoef
Music is a peculiar human behavior. While very common in our species, we still know very little as to why and how music emerged. For centuries, the study of music has been the sole prerogative of the humanities. Lately, however, music is being increasingly investigated by psychologists, neuroscientists, biologists, and computer scientists. One possible approach to study the origins of music is to hypothesize and empirically test the mechanisms behind this structured behavior. Recent experiments in the lab have shown how musical rhythm and melody can emerge via the process of cultural transmission...
April 17, 2018: Artificial Life
https://www.readbyqxmd.com/read/29663590/use-of-deferasirox-exjade-for-iron-overload-in-peritoneal-dialysis-patients
#15
Erwin Yii, James Cg Doery, Zane Kaplan, Peter G Kerr
BACKGROUND: A 54 year old male with β-Thalassemia major developed ESRD and was managed with continuous ambulatory peritoneal dialysis. Although not able to be transfused due to high titre red cell antibodies he did require management of iron overload. Deferasirox (Exjade) was administered orally. There was concern that excretion of iron via the peritoneal dialysate may raise the risk of iron-dependent infections (Yersinia and Rhizopus). METHODS: Whilst receiving Exjade 1000mg /day, a total collection of 12...
April 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29661657/reprint-of-the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#16
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
March 26, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29659534/clinical-management-of-low-vitamin-d-a-scoping-review-of-physicians-practices
#17
REVIEW
Michelle Rockwell, Vivica Kraak, Matthew Hulver, John Epling
The role of vitamin D in the prevention and treatment of non-skeletal health issues has received significant media and research attention in recent years. Costs associated with clinical management of low vitamin D (LVD) have increased exponentially. However, no clear evidence supports vitamin D screening to improve health outcomes. Authoritative bodies and professional societies do not recommend population-wide vitamin D screening in community-dwelling adults who are asymptomatic or at low risk of LVD. To assess patterns of physicians’ management of LVD in this conflicting environment, we conducted a scoping review of three electronic databases and the gray literature...
April 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29659528/automated-quality-control-for-sensor-based-symptom-measurement-performed-outside-the-lab
#18
Reham Badawy, Yordan P Raykov, Luc J W Evers, Bastiaan R Bloem, Marjan J Faber, Andong Zhan, Kasper Claes, Max A Little
The use of wearable sensing technology for objective, non-invasive and remote clinimetric testing of symptoms has considerable potential. However, the accuracy achievable with such technology is highly reliant on separating the useful from irrelevant sensor data. Monitoring patient symptoms using digital sensors outside of controlled, clinical lab settings creates a variety of practical challenges, such as recording unexpected user behaviors. These behaviors often violate the assumptions of clinimetric testing protocols, where these protocols are designed to probe for specific symptoms...
April 16, 2018: Sensors
https://www.readbyqxmd.com/read/29657419/giardiasis-serum-antibodies-and-coproantigens-in-brown-rats-rattus-norvegicus-from-grenada-west-indies
#19
Keshaw Tiwari, Camille Coomansingh Springer, Alfred Chikweto, Josephine Tang, Yvette Sepulveda, Amanda Leigh Smith, Nia Rametta, Ravindra Nath Sharma
Aim: Giardia is a serious zoonotic parasite, which causes diarrheal disease in humans and animals including rodents. The purpose of this study was to estimate the prevalence of Giardia spp. in brown rats ( Rattus norvegicus ) in Grenada. Materials and Methods: Intestinal contents from 99 and serum samples from 169 brown rats ( R. norvegicus ) from Grenada were collected. These samples were examined for the Giardia coproantigens using Cryptosporidium / Giardia Quik Chek assay (Tech lab® Inc...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29656125/strategic-ultrasound-induced-stress-response-of-lactic-acid-bacteria-on-enhancement-of-%C3%AE-glucosidase-activity-for-bioconversion-of-isoflavones-in-soymilk
#20
Wen-Sin Liu, Chun-Yao Yang, Tony J Fang
The purpose of the study is to develop the new methodology of strategic ultrasound treatment on lactic acid bacteria (LAB) to induce stress response for the enhancement of β-glucosidase activity that can be used for the biotransformation of glucosides into aglycones isoflavones in soymilk. Among the five LAB tested, Lactobacillus acidophilus BCRC 10695 showed the best ability to release β-glucosidase for further ultrasonic stimulation to induce proper stress response. With ultrasound (20 kHz, amplitude at 20%) to irradiate on L...
April 12, 2018: Journal of Microbiological Methods
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