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https://www.readbyqxmd.com/read/28339629/orders-on-file-but-no-labs-drawn-investigation-of-machine-and-human-errors-caused-by-an-interface-idiosyncrasy
#1
Richard Schreiber, Dean F Sittig, Joan Ash, Adam Wright
In this report, we describe 2 instances in which expert use of an electronic health record (EHR) system interfaced to an external clinical laboratory information system led to unintended consequences wherein 2 patients failed to have laboratory tests drawn in a timely manner. In both events, user actions combined with the lack of an acknowledgment message describing the order cancellation from the external clinical system were the root causes. In 1 case, rapid, near-simultaneous order entry was the culprit; in the second, astute order management by a clinician, unaware of the lack of proper 2-way interface messaging from the external clinical system, led to the confusion...
February 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339438/the-role-of-autonomic-function-in-exercise-induced-endogenous-analgesia-a-case-control-study-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-and-healthy-people
#2
Jessica Van Oosterwijck, Uros Marusic, Inge De Wandele, Lorna Paul, Mira Meeus, Greta Moorkens, Luc Lambrecht, Lieven Danneels, Jo Nijs
BACKGROUND: Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are unable to activate brain-orchestrated endogenous analgesia (or descending inhibition) in response to exercise. This physiological impairment is currently regarded as one factor explaining post-exertional malaise in these patients. Autonomic dysfunction is also a feature of ME/CFS. OBJECTIVES: This study aims to examine the role of the autonomic nervous system in exercise-induced analgesia in healthy people and those with ME/CFS, by studying the recovery of autonomic parameters following aerobic exercise and the relation to changes in self-reported pain intensity...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28328894/laboratory-environmental-factors-and-pain-behavior-the-relevance-of-unknown-unknowns-to-reproducibility-and-translation
#3
Jeffrey S Mogil
The poor record of basic-to-clinical translation in recent decades has led to speculation that preclinical research is "irreproducible", and this irreproducibility in turn has largely been attributed to deficiencies in reporting and statistical practices. There are, however, a number of other reasonable explanations of both poor translation and difficulties in one laboratory replicating the results of another. This article examines these explanations as they pertain to preclinical pain research. I submit that many instances of apparent irreproducibility are actually attributable to interactions between the phenomena and interventions under study and "latent" environmental factors affecting the rodent subjects...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328885/introducing-therioepistemology-the-study-of-how-knowledge-is-gained-from-animal-research
#4
REVIEW
Joseph P Garner, Brianna N Gaskill, Elin M Weber, Jamie Ahloy-Dallaire, Kathleen R Pritchett-Corning
This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the first time, the scale of the reproducibility and translatability crisis is widely understood beyond the small cadre of researchers who have been studying it and the pharmaceutical and biotech companies who have been living it. Here we argue that an emerging literature, including the papers in this focus issue, has begun to congeal around a set of recurring themes, which themselves represent a paradigm shift. This paradigm shift can be characterized at the micro level as a shift from asking "what have we controlled for in this model?" to asking "what have we chosen to ignore in this model, and at what cost?" At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28327888/fibromuscular-dysplasia-unusual-cause-of-abdominal-pain
#5
M Alonso-Alcañiz, J M Antolín, J R Rebolledo, C Muñoz-Montano
Spontaneous dissection of the renal artery is a rare phenomenon, and is more common amongst men. It is not a frequent cause of abdominal pain², which is why diagnosis is often late. The case under study is a 45 year old patient that presented sudden pain in the left renal fossa of 12 hours evolution, with no findings from the basic laboratory tests (lab testing, urinary sediment and ultrasound), an abdominal CAT was therefore carried out, which showed areas of renal infarction, as well as an emergency arteriogram, which gave findings of a possible Fibromuscular Dysplasia of the left intrarenal artery as the first diagnostic probability with a partially thrombosed focal dissection...
June 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/28326045/attainable-and-relevant-moral-exemplars-are-more-effective-than-extraordinary-exemplars-in-promoting-voluntary-service-engagement
#6
Hyemin Han, Jeongmin Kim, Changwoo Jeong, Geoffrey L Cohen
The present study aimed to develop effective moral educational interventions based on social psychology by using stories of moral exemplars. We tested whether motivation to engage in voluntary service as a form of moral behavior was better promoted by attainable and relevant exemplars or by unattainable and irrelevant exemplars. First, experiment 1, conducted in a lab, showed that stories of attainable exemplars more effectively promoted voluntary service activity engagement among undergraduate students compared with stories of unattainable exemplars and non-moral stories...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28324615/construction-of-low-ethanol-wine-yeasts-through-partial-deletion-of-the-saccharomyces-cerevisiae-pdc2-gene
#7
Raúl Andrés Cuello, Karina Johana Flores Montero, Laura Analía Mercado, Mariana Combina, Iván Francisco Ciklic
We propose an alternative GMO based strategy to obtain Saccharomyces cerevisiae mutant strains with a slight reduction in their ability to produce ethanol, but with a moderate impact on the yeast metabolism. Through homologous recombination, two truncated Pdc2p proteins Pdc2pΔ344 and Pdc2pΔ519 were obtained and transformed into haploid and diploid lab yeast strains. In the pdc2Δ344 mutants the DNA-binding and transactivation site of the protein remain intact, whereas in pdc2Δ519 only the DNA-binding site is conserved...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28322631/priming-patient-safety-through-nursing-handoff-communication
#8
Patricia S Groves, Jacinda L Bunch, Ellen Cram, Amany Farag, Kirstin Manges, Yelena Perkhounkova, Jill Scott-Cawiezell
Understanding how safety culture mechanisms affect nursing safety-oriented behavior and thus patient outcomes is critical to developing hospital safety programs. Safety priming refers to communicating safety values intended to activate patient safety goals. Safety priming through nursing handoff communication was tested as a means by which cultural safety values may affect nursing practice. The mixed-methods pilot study setting was an academic medical center's high-fidelity simulation lab. Twenty nurses were randomized into intervention and control groups...
October 1, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28321412/recombinant-lactococcus-lactis-expressing-haemagglutinin-from-a-polish-avian-h5n1-isolate-and-its-immunological-effect-in-preliminary-animal-trials
#9
Agnieszka K Szczepankowska, Katarzyna Szatraj, Przemysław Sałański, Agnieszka Rózga, Roman K Górecki, Jacek K Bardowski
Lactic acid bacteria (LAB) are Gram-positive, nonpathogenic microorganisms that are gaining much interest as antigen producers for development of live vaccine vectors. Heterologous proteins of different origin have been successfully expressed in various LAB species, including Lactococcus lactis. Recombinant L. lactis strains have been shown to induce specific local and systemic immune responses against various antigens. Our study aimed at constructing a L. lactis strain expressing haemagglutinin of a Polish avian H5H1 influenza isolate and examining its effect on animals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28321289/art-perception-in-the-museum-how-we-spend-time-and-space-in-art-exhibitions
#10
Claus-Christian Carbon
Aesthetics research aiming at understanding art experience is an emerging field; however, most research is conducted in labs without access to real artworks, without the social context of a museum and without the presence of other persons. The present article replicates and complements key findings of art perception in museum contexts. When observing museum visitors (N = 225; 126 female, M(age) = 43.3 years) while perceiving a series of six Gerhard Richter paintings of various sizes (0.26-3.20 sq...
January 2017: I-Perception
https://www.readbyqxmd.com/read/28320473/which-neural-mechanisms-mediate-the-effects-of-a-parenting-intervention-program-on-parenting-behavior-design-of-a-randomized-controlled-trial
#11
Laura Kolijn, Saskia Euser, Bianca G van den Bulk, Renske Huffmeijer, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
BACKGROUND: The Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD) has proven effective in increasing parental sensitivity. However, the mechanisms involved are largely unknown. In a randomized controlled trial we examine parental neurocognitive factors that may mediate the intervention effects on parenting behavior. Our aims are to (1) examine whether the intervention influences parents' neural processing of children's emotional expressions and the neural precursors of response inhibition and to (2) test whether neural changes mediate intervention effects on parenting behavior...
March 21, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28319182/the-viability-of-an-ecologically-valid-chronic-sleep-restriction-and-circadian-timing-protocol-an-examination-of-sample-attrition-compliance-and-effectiveness-at-impacting-sleepiness-and-mood
#12
David L Dickinson, Sean P A Drummond, Todd McElroy
Chronic sleep restriction (SR) increases sleepiness, negatively impacts mood, and impairs a variety of cognitive performance measures. The vast majority of work establishing these effects are tightly controlled in-lab experimental studies. Examining commonly-experienced levels of SR in naturalistic settings is more difficult and generally involves observational methods, rather than active manipulations of sleep. The same is true for analyzing behavioral and cognitive outcomes at circadian unfavorable times...
2017: PloS One
https://www.readbyqxmd.com/read/28318565/the-counterintuitive-role-of-extra-column-volume-in-the-determination-of-column-efficiency-and-scaling-of-chromatographic-processes
#13
A Schultze-Jena, M A Boon, P J Th Bussmann, A E M Janssen, A van der Padt
In industrial liquid separation processes chromatography often has a key function in the optimization of yield and purity. For the design of an industrial system, chromatographic processes are generally simulated using mathematical models, tested and optimized at laboratory level, and then scaled up to pilot and subsequently industrial scale. To describe the system, experimental data and model data need to be fitted and extra column contribution must be determined. This paper describes the influence of extra-column volume on overall separation efficiency for lab scale and its impact on the design of large scale systems...
March 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28318329/intact-parathyroid-hormone-levels-and-primary-hyperparathyroidism
#14
Haidar Al-Hraishawi, Peter J Dellatore, Xinjiang Cai, Xiangbing Wang
OBJECTIVE: The aim of this article is to compare clinical characteristics and lab values for metabolic syndrome between primary hyperparathyroidism (PHPT) patients with different levels of serum intact parathyroid hormone (iPTH) and to determine correlation between different clinical characteristics among PHPT patients Methods: We reviewed charts of 212 PHPT patients in this retrospective study. Patients were divided into two groups according to their initial serum iPTH levels. Student's t-tests were used to compare the two groups for differences in clinical characteristics and laboratory values...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28317381/upscaled-bioammonium-ammonia-production-by-clostridium-aminophilum-cultured-with-soy-protein-isolate
#15
Brian K Ward, Robert J Dufault, Richard Hassell, Matthew A Cutulle
The goal of this study was to upscale the production of bioammonium/ammonia (BAA) by Clostridium aminophilum from test tube size small batches of 1.0 g soy-protein-isolate (SPI) with 10 mL salt solution to the lab scale bioreactor level of 1.8 kg·18 L salt solution in amounts required for precision fertigation in field trials. An 18L bioreactor was designed and constructed similar to commercially available lab scale bioreactors. Novel methods were implemented to maintain sterility and anaerobic conditions throughout the preparation and operation of the bioreactor...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28317212/binge-drinking-and-family-history-of-alcoholism-are-associated-with-an-altered-developmental-trajectory-of-impulsive-choice-across-adolescence
#16
Scott A Jones, Joel S Steele, Bonnie J Nagel
AIMS: To test whether binge drinking, the density of familial alcoholism (FHD), and their interaction are associated with an altered developmental trajectory of impulsive choice across adolescence, and whether more lifetime drinks is associated with a greater change in impulsive choice across age. DESIGN: Alcohol-naïve adolescents, with varying degrees of FHD, were recruited as part of an ongoing longitudinal study on adolescent development, and were grouped based on whether they remained non-drinkers (n = 83) or initiated binge drinking (n = 33) during follow-up...
March 20, 2017: Addiction
https://www.readbyqxmd.com/read/28316135/variability-of-cut-off-values-for-the-detection-of-lupus-anticoagulants-results-of-an-international-multicenter-multiplatform-study
#17
Armando Tripodi, Veena Chantarangkul, Michela Cini, Katrien Devreese, Jeffrey S Dlott, Roberta Giacomello, Elaine Gray, Cristina Legnani, Marta E Martinuzzo, Paola Pradella, Annelie Siegemund, Sitalakshmi Subramanian, Pierre Suchon, Sophie Testa
BACKGROUND: Cut-off values for results interpretation of lupus anticoagulant (LA) detection are poorly investigated. AIMS: (i) To assess whether results from healthy donors were normally distributed and (ii) the between-laboratories differences of cut-off values for screening, mixing and LA confirmation when calculated as 99(th) or 95(th) centiles, and (iii) to assess their impact on LA detection-rate. METHODS: Each of 11 labs using one of the 3 widely-used commercial platforms for LA detection was asked to collect plasmas from 120 healthy donors and to perform screening, mixing and LA confirmation with two methods (activated partial thromboplastin time [APTT]- and dilute Russell viper venom [dRVV]-derived)...
March 17, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28316027/validation-of-dopamine-receptor-drd1-and-drd2-antibodies-using-receptor-deficient-mice
#18
Tamara Stojanovic, Michaela Orlova, Fernando J Sialana, Harald Höger, Stanislav Stuchlik, Ivan Milenkovic, Jana Aradska, Gert Lubec
Dopamine receptors 1 and 2 (DRD1, DRD2) are essential for signaling in the brain for a multitude of brain functions. Previous work using several antibodies against these receptors is abundant but only the minority of antibodies used have been validated and, therefore, the results of these studies remain uncertain. Herein, antibodies against DRD1 (Merck Millipore AB1765P, Santa Cruz Biotechnology sc-14001, Sigma Aldrich D2944, Alomone Labs ADR-001) and DRD2 (Abcam ab21218, Merck Millipore AB5084P, Santa Cruz Biotechnology sc-5303) have been tested using western blotting and immunohistochemistry on mouse striatum (wild type and corresponding knock-out mice) and when specific, they were further evaluated on rat and human striatum...
March 18, 2017: Amino Acids
https://www.readbyqxmd.com/read/28303757/evaluation-of-microalgae-production-coupled-with-wastewater-treatment
#19
Davide De Francisci, Yixi Su, Arvo Iital, Irini Angelidaki
In the present study the feasibility of microalgae production coupled with wastewater treatment was assessed. Continuous cultivation of Chlorella sorokiniana with wastewater was tested in lab-scale flat panel photobioreactors. Biomass productivity was determined for four dilution rates (4.32 d(-1), 3.6 d(-1), 1.8 d(-1) and 0.72 d(-1)). The productivity peak was 1.524 g l(-1)d(-1) at the dilution rate of 2.41 d(-1). Nitrogen and phosphorus removals were found to be inversely proportional to dilution rates, while COD removal was found to be 50% at all the tested conditions...
March 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28302091/development-of-a-test-that-measures-real-time-her2-signaling-function-in-live-breast-cancer-cell-lines-and-primary-cells
#20
Yao Huang, David J Burns, Benjamin E Rich, Ian A MacNeil, Abhijit Dandapat, Sajjad M Soltani, Samantha Myhre, Brian F Sullivan, Carol A Lange, Leo T Furcht, Lance G Laing
BACKGROUND: Approximately 18-20% of all human breast cancers have overexpressed human epidermal growth factor receptor 2 (HER2). Standard clinical practice is to treat only overexpressed HER2 (HER2+) cancers with targeted anti-HER2 therapies. However, recent analyses of clinical trial data have found evidence that HER2-targeted therapies may benefit a sub-group of breast cancer patients with non-overexpressed HER2. This suggests that measurement of other biological factors associated with HER2 cancer, such as HER2 signaling pathway activity, should be considered as an alternative means of identifying patients eligible for HER2 therapies...
March 16, 2017: BMC Cancer
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