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Zain Mumtaz, Saleem Ullah, Zeeshan Ilyas, Naila Aslam, Shahid Iqbal, Shuo Liu, Jehangir Arshad Meo, Hamza Ahmad Madni
We present an Arduino-based automation system to control the streetlights based on solar rays and object's detection. We aim to design various systems to achieve the desired operations, which no longer require time-consuming manual switching of the streetlights. The proposed work is accomplished by using an Arduino microcontroller, a light dependent resistor (LDR) and infrared-sensors while, two main contributions are presented in this work. Firstly, we show that the streetlights can be controlled based on the night and object's detection...
September 20, 2018: Sensors
Piotr Skrzypczyk, Małgorzata Mizerska-Wasiak, Anna Ofiara, Michał Szyszka, Jagoda Kułagowska, Agnieszka Biejat, Michał Brzewski, Beata Kucińska, Bożena Werner, Małgorzata Pańczyk-Tomaszewska
Thromboembolic complications are found in 2-3% of children with nephrotic syndrome (NS); this increased risk is caused by hypovolemia, hemoconcentration, increased number and activity of platelets, hyperfibrinogenemia and loss of coagulation inhibitors. Risk is even higher in case of additional factors e.g. congenital thrombophilia. CASE REPORT: Girl with NS aged 17 11/12 years was admitted to hospital due to respiratory tract infection with cough and back pain. NS started 9 months earlier and she had two bouts of disease, and was treated only with prednisone (current dose - 60 mg/48h)...
September 21, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Nicolas Fiorini, Kathi Canese, Rostyslav Bryzgunov, Ievgeniia Radetska, Asta Gindulyte, Martin Latterner, Vadim Miller, Maxim Osipov, Michael Kholodov, Grisha Starchenko, Evgeny Kireev, Zhiyong Lu
PubMed is a freely accessible system for searching the biomedical literature, with $ \sim $ 2.5 million users worldwide on an average workday. In order to better meet our users' needs in an era of information overload, we have recently developed PubMed Labs (, an experimental system for users to test new search features/tools (e.g. Best Match) and provide feedback, which enables us to make more informed decisions about potential changes to improve the search quality and overall usability of PubMed...
January 1, 2018: Database: the Journal of Biological Databases and Curation
Christian Brandt, Nanna Brande-Lavridsen, Jakob Christensen-Dalsgaard
The auditory brainstem response (ABR) is relatively non-invasive, and in many species, the only practical way to assess auditory sensitivity. The two main methods for measuring ABR are using either transients or tone bursts as a stimulus. The transient stimulus produces strong neural responses that contain no frequency information. In contrast, tone bursts stimulate only a small part of the auditory system, eliciting weaker neural responses but supplying frequency information. Furthermore, short tone bursts become less and less frequency specific with increasing stimulus wavelength, making them unsuitable for testing low-frequency hearing...
September 20, 2018: Journal of the Association for Research in Otolaryngology: JARO
Emily A Brown, Jonathan D Lautz, Tessa R Davis, Edward P Gniffke, Alison A W VanSchoiack, Steven C Neier, Noah Tashbook, Chiara Nicolini, Margaret Fahnestock, Adam G Schrum, Stephen E P Smith
Background: Autism spectrum disorders (ASDs) are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and several environmental risk factors. Mouse models of specific risk factors have been successful in identifying molecular mechanisms associated with a given factor. However, comparisons among different models to elucidate underlying common pathways or to define clusters of biologically relevant disease subtypes have been complicated by different methodological approaches or different brain regions examined by the labs that developed each model...
2018: Molecular Autism
Natalia S Brizuela, Bárbara M Bravo-Ferrada, Yolanda Curilén, Lucrecia Delfederico, Adriana Caballero, Liliana Semorile, M Ángeles Pozo-Bayón, E Elizabeth Tymczyszyn
The malolactic fermentation (MLF) of Patagonian Malbec wine inoculated with blend cultures of selected native strains of Lactobacillus plantarum and Oenococcus oeni was monitored during 14 days, analyzing the strains ability to modify the content of some organic acids and to change the volatile compounds profile. The performance of the LAB strains was tested as single and blends cultures of both species. An implantation control by RAPD PCR was also carried out to differentiate among indigenous and inoculated strains...
2018: Frontiers in Microbiology
Henryk Zieliński, Dorota Szawara-Nowak, Natalia Bączek, Małgorzata Wronkowska
The influence of liquid-state fermentation (LSF) by selected lactic acid bacteria (LAB) and Rhizopus oligosporus fungi on the content of rutin and total phenolic compounds (TPC), antioxidant capacity measured by ABTS test, FRAP assay and photochemiluminescence technique, and the inhibitory activity against formation of fluorescent advanced glycation end-products (AGEs) in vitro of raw and roasted buckwheat flours was studied. LSF caused a slight, specific LAB-dependent increase in TPC and a decrease in rutin content...
January 15, 2019: Food Chemistry
Chenchen Ma, Tieming Ji
BACKGROUND: Using next-generation sequencing technology to measure gene expression, an empirically intriguing question concerns the identification of differentially expressed genes across treatment groups. Existing methods aim to identify genes whose mean expressions differ among treatment groups by assuming equal dispersion across all groups. For syndromes, however, various combinations of gene expression alterations can result in the same disease, leading to greater heteroscedasticity in the biological replicates in the disease group compared to the normal group...
September 20, 2018: BMC Bioinformatics
Houtan Jebelli, Mohammad Mahdi Khalili, SangHyun Lee
Recognizing the factors that cause stress is a crucial step toward early detection of stressors. In this regard, several studies make an effort to recognize individuals' stress using an Electroencephalogram (EEG). However, current EEG-based stress recognition frameworks have several drawbacks. First, they are mostly designed to recognize individuals' stress only in a controlled laboratory environment. Second, they do not take into account the changes in the EEG signals of different subjects under the same stressors...
September 18, 2018: IEEE Journal of Biomedical and Health Informatics
Serena Vickers, Matthew Bernier, Stephen Zambrzycki, Facundo M Fernandez, Paul N Newton, Céline Caillet
Background: Poor quality medicines have devastating consequences. A plethora of innovative portable devices to screen for poor quality medicines has become available, leading to hope that they could empower medicine inspectors and enhance surveillance. However, information comparing these new technologies is woefully scarce. Methods: We undertook a systematic review of Embase, PubMed, Web of Science and SciFinder databases up to 30 April 2018. Scientific studies evaluating the performances/abilities of portable devices to assess any aspect of the quality of pharmaceutical products were included...
2018: BMJ Global Health
Rocío Fernández-Pérez, Yolanda Sáenz, Beatriz Rojo-Bezares, Myriam Zarazaga, Juan M Rodríguez, Carmen Torres, Carmen Tenorio, Fernanda Ruiz-Larrea
Lactic acid bacteria (LAB) are responsible for the malolactic fermentation of wines, and, therefore, controlling the growth of these bacteria is a key factor for elaborating premium wines. Sulfur dioxide has been traditionally used as an efficient antimicrobial and antioxidant agent, however, nowadays consumers' demand tends toward a reduction of sulfur dioxide levels in wine and other fermented foods. A previous study of our research group had demonstrated the effectiveness of the bacteriocin nisin to inhibit the growth of enological LAB, and its activity had been tested in culture broths...
2018: Frontiers in Microbiology
Huma Rasheed, Ludwig Höllein, Ulrike Holzgrabe
Substandard and falsified (SF) medicines have emerged as a global public health issue within the last two decades especially in low- and middle-income countries (LMICs). Serious consequences of this problem include a loss of trust and increased financial costs due to less disease control and more frequent complications during therapy. Of note, antimicrobial resistance is an additional long-term implication of poor-quality antimicrobials. This review covers information technology tools including medicines authentication tools (MAT) as mobile apps and messaging service, 2D barcoding approaches with drug safety alert systems, web based drug safety alerts, radiofrequency identification tags, databases to support visual inspection, digital aids to enhance the performance of quality evaluation kits, reference libraries for identification of falsified and substandard medicines, and quality evaluation kits based on machine learning for field testing...
2018: Frontiers in Pharmacology
Bao Le, Seung-Hwan Yang
Cholesterol-lowering activity is an important health benefit of lactic acid bacteria (LAB). This study aimed to screen LAB strains with cholesterol-lowering activities from salted fermented shrimp and evaluate probiotic characteristics and cholesterol-lowering potentials of these LAB isolates. Among 191 lactic acid strains isolated from traditional salted-fermented shrimp food, FB003 isolate showed the highest cholesterol-lowering activity and investigated as probiotics with cholesterol-lowering ability. Biochemical analysis and 16S rRNA sequencing revealed that this LAB isolate was Lactobacillus plantarum FB003...
September 18, 2018: Probiotics and Antimicrobial Proteins
Stephanie A Bodily, Claudia Delgado-Corcoran, Katherine Wolpert, Kathryn Lucas, Angela P Presson, Susan L Bratton
Introduction: Frequent blood testing increases risk of iatrogenic anemia, infection, and blood transfusion. This study describes 3 years of sustained blood testing reduction from a quality improvement (QI) initiative which began in 2011. Methods: The cohort consisted of postop children whose surgery had a Risk Adjustment for Congenital Heart Surgery (RACHS) classification consecutively admitted to a tertiary Cardiac Intensive Care Unit. Data were collected for a 2010 preintervention, 2011 intervention, and 2012-13 postintervention periods, tabulating common laboratory studies per patient (labs/pt) and adjusted for length of stay (labs/pt/d)...
November 2017: Pediatric Quality & Safety
Bhairvi Jani, Elizabeth Marsicano
Constipation is defined as the infrequent passage of stools or difficulty with evacuation of stools. Constipation can be classified as primary or secondary, and primary constipation can be further divided into slow transit constipation or outlet obstruction. The diagnostic workup involves focused lab tests and structural evaluation, followed by a therapeutic trial of fiber and laxatives, and finally, specialized tests. Treatment can consist of dietary changes, medications, physical therapy, and possibly surgery in refractory cases...
May 2018: Missouri Medicine
Mohammad Abbasi, Andrew D Smith, Harish Swaminathan, Peer Sangngern, Amanda Douglas, Alan Horsager, Douglas T Carrell, Philip J Uren
BACKGROUND: Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of poor embryo development. Moving these initial findings from the lab into a clinical setting where they can be used to measure male infertility though requires a platform that is stable and robust against batch effects that can occur between sample runs. Operating parameters must be established, performance characteristics determined, and guidelines set to ensure repeatability and accuracy...
September 18, 2018: Clinical Epigenetics
R Kutaimy, L Zhang, D Blok, R Kelly, N Kovacevic, M Levoska, R Gadivemula, D Levine
BACKGROUND: Introducing patient safety and quality improvement science to medical students is integral to improving healthcare. However, developing and implementing a patient safety curriculum can be challenging in a medical school curriculum that is already densely packed. Our aim was to develop and evaluate the impact of a workshop introducing patient safety and quality improvement science to a large class of first-year medical students. METHOD: As a part of an evolving longitudinal patient safety curriculum, an introductory workshop on patient safety was integrated into an anatomy course...
September 18, 2018: BMC Medical Education
Miguel A Vadillo, Natalie Gold, Magda Osman
According to a popular model of self-control, willpower depends on a limited resource that can be depleted when we perform a task demanding self-control. This theory has been put to the test in hundreds of experiments showing that completing a task that demands high self-control usually hinders performance in any secondary task that subsequently taxes self-control. Over the last 5 years, the reliability of the empirical evidence supporting this model has been questioned. In the present study, we reanalysed data from a large-scale study-Many Labs 3-to test whether performing a depleting task has any effect on a secondary task that also relies on self-control...
August 2018: Royal Society Open Science
Minghuo Wu, Lin Fu, Yufeng Hu, Jingyun Su, Siyuan Jing, Hao Zhou, Jingjing Zhan
A multiplex on-bead isotope dimethyl labeling method was developed for the quantitative analysis of sulfonamides (SAs) in environmental water samples by liquid chromatography-high resolution mass spectrometry (LC-HRMS). In this method, 5 samples could be labeled in parallel with different isotope regents, respectively, and quantified in a single LC-HRMS analysis. A magnetic solid phase extraction (MSPE) was employed in the sample preparation to concentrate the trace level analytes by using a lab synthesized magnetic carbon nanospheres (MCNS)...
September 17, 2018: Analytical Chemistry
Ali Hosseinsabet, Mohsen Faal, Akbar Shafiee, Hassan Aghajani, Maryam Sotoudeh Anvari, Arash Jalali, Younes Nozari, Hamidreza Pourhosseini, Mojtaba Salarifar, Alireza Amirzadegan, Seyed Ebrahim Kassaian, Mohammad Alidoosti, Alimohammad Hajizeinali, Ebrahim Nematipour
BACKGROUND: Coronary artery ectasia (CAE) is identified as dilation of one or more segments of coronary arteries that reaches 1.5 times or more, compared with near segments that are normal. Several etiologies like atherosclerosis, autoimmune diseases and congenital anomalies have been proposed for this condition. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For these reasons, we investigated the serum level of vitamin D in patients with CAE compared with individuals with normal coronary arteries...
September 1, 2018: Archives of Iranian Medicine
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