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https://www.readbyqxmd.com/read/29471380/dysarthria-in-mandarin-speaking-children-with-cerebral-palsy-speech-subsystem-profiles
#1
Li-Mei Chen, Katherine C Hustad, Ray D Kent, Yu Ching Lin
Purpose: This study explored the speech characteristics of Mandarin-speaking children with cerebral palsy (CP) and typically developing (TD) children to determine (a) how children in the 2 groups may differ in their speech patterns and (b) the variables correlated with speech intelligibility for words and sentences. Method: Data from 6 children with CP and a clinical diagnosis of moderate dysarthria were compared with data from 9 TD children using a multiple speech subsystems approach...
February 22, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29470664/toward-miniaturized-analysis-of-chemical-identity-and-purity-of-radiopharmaceuticals-via-microchip-electrophoresis
#2
Jimmy Ly, Noel S Ha, Shilin Cheung, R Michael van Dam
Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer numerous advantages including reduced tracer production costs and increased availability of diverse tracers. While many steps of the tracer production process have been miniaturized, there has been relatively little development of microscale systems for the quality control (QC) testing process that is required by regulatory agencies to ensure purity, identity, and biological safety of the radiotracer before use in human subjects...
February 22, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29466947/stroke-as-an-atypical-initial-presentation-of-giant-cell-arteritis
#3
Tharsika Kuganesan, Allen R Huang
BACKGROUND: Giant cell arteritis (GCA) is an immune mediated inflammatory disease of medium and large arteries which afflicts older people. The classical presentation features include: headache, visual disturbances, and jaw claudication. Patients diagnosed with GCA have also been observed to be at higher risk for the subsequent development of strokes. CASE PRESENTATION: We describe a case of an 84-year old right-handed man who presented to hospital with dysarthria, dysphagia, right-sided facial drop, a history of generalized weakness and multiple falls...
February 21, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29466319/skin-on-a-chip-transepithelial-electrical-resistance-and-extracellular-acidification-measurements-through-an-automated-air-liquid-interface
#4
Frank A Alexander, Sebastian Eggert, Joachim Wiest
Skin is a critical organ that plays a crucial role in defending the internal organs of the body. For this reason, extensive work has gone into creating artificial models of the epidermis for in vitro skin toxicity tests. These tissue models, called reconstructed human epidermis (RhE), are used by researchers in the pharmaceutical, cosmetic, and environmental arenas to evaluate skin toxicity upon exposure to xenobiotics. Here, we present a label-free solution that leverages the use of the intelligent mobile lab for in vitro diagnostics (IMOLA-IVD), a noninvasive, sensor-based platform, to monitor the transepithelial electrical resistance (TEER) of RhE models and adherent cells cultured on porous membrane inserts...
February 21, 2018: Genes
https://www.readbyqxmd.com/read/29463917/infant-temperament-and-parent-use-of-food-to-soothe-predict-change-in-weight-for-length-across-infancy-early-risk-factors-for-childhood-obesity
#5
Cynthia A Stifter, Kameron J Moding
OBJECTIVES: Greater weight gain in infancy is a risk factor for childhood obesity. The present study examined the interaction between infant temperament and parent use of food to soothe infant distress (FTS) as predictors of weight gain across the first 2 years of life. SUBJECTS/METHODS: A total of 160 mother-infant dyads were recruited into a longitudinal study. Infant temperament was assessed by parents through a questionnaire (surgency, negativity) and by observer ratings (surgency, irritability) during a laboratory visit when infants were 6 months old...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29463182/registered-replication-report-dijksterhuis-and-van-knippenberg-1998
#6
Michael O'Donnell, Leif D Nelson, Evi Ackermann, Balazs Aczel, Athfah Akhtar, Silvio Aldrovandi, Nasseem Alshaif, Ronald Andringa, Mark Aveyard, Peter Babincak, Nursena Balatekin, Scott A Baldwin, Gabriel Banik, Ernest Baskin, Raoul Bell, Olga Białobrzeska, Angie R Birt, Walter R Boot, Scott R Braithwaite, Jessie C Briggs, Axel Buchner, Desiree Budd, Kathryn Budzik, Lottie Bullens, Richard L Bulley, Peter R Cannon, Katarzyna Cantarero, Joseph Cesario, Stephanie Chambers, Christopher R Chartier, Peggy Chekroun, Clara Chong, Axel Cleeremans, Sean P Coary, Jacob Coulthard, Florien M Cramwinckel, Thomas F Denson, Marcos Díaz-Lago, Theresa E DiDonato, Aaron Drummond, Julia Eberlen, Titus Ebersbach, John E Edlund, Katherine M Finnigan, Justin Fisher, Natalia Frankowska, Efraín García-Sánchez, Frank D Golom, Andrew J Graves, Kevin Greenberg, Mando Hanioti, Heather A Hansen, Jenna A Harder, Erin R Harrell, Andree Hartanto, Michael Inzlicht, David J Johnson, Andrew Karpinski, Victor N Keller, Olivier Klein, Lina Koppel, Emiel Krahmer, Anthony Lantian, Michael J Larson, Jean-Baptiste Légal, Richard E Lucas, Dermot Lynott, Corey M Magaldino, Karlijn Massar, Matthew T McBee, Neil McLatchie, Nadhilla Melia, Michael C Mensink, Laura Mieth, Samantha Moore-Berg, Geraldine Neeser, Ben R Newell, Marret K Noordewier, Asil Ali Özdogğru, Myrto Pantazi, Michał Parzuchowski, Kim Peters, Michael C Philipp, Monique M H Pollmann, Panagiotis Rentzelas, Rosa Rodríguez-Bailón, Jan Philipp Röer, Ivan Ropovik, Nelson A Roque, Carolina Rueda, Bastiaan T Rutjens, Katey Sackett, Janos Salamon, Ángel Sánchez-Rodríguez, Blair Saunders, Juliette Schaafsma, Michael Schulte-Mecklenbeck, David R Shanks, Martin F Sherman, Kenneth M Steele, Niklas K Steffens, Jessie Sun, Kyle J Susa, Barnabas Szaszi, Aba Szollosi, Ricardo M Tamayo, Gustav Tinghög, Yuk-Yue Tong, Carol Tweten, Miguel A Vadillo, Deisy Valcarcel, Nicolas Van der Linden, Michiel van Elk, Frenk van Harreveld, Daniel Västfjäll, Simine Vazire, Philippe Verduyn, Matt N Williams, Guillermo B Willis, Sarah E Wood, Chunliang Yang, Oulmann Zerhouni, Robert Zheng, Mark Zrubka
Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence ("professor") subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence ("soccer hooligans"). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9...
February 1, 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29462341/laboratory-evaluation-of-commercially-available-platforms-to-detect-west-nile-and-zika-viruses-from-honey-cards
#7
Kristen L Burkhalter, Keenan Wiggins, Nathan Burkett-Cadena, Barry W Alto
Commercially available assays utilizing antigen or nucleic acid detection chemistries provide options for mosquito control districts to screen their mosquito populations for arboviruses and make timely operational decisions regarding vector control. These assays may be utilized even more advantageously when combined with honey-soaked nucleic acid preservation substrate ('honey card') testing by reducing or replacing the time- and labor-intensive efforts of identifying and processing mosquito pools. We tested artificially inoculated honey cards and cards fed upon individually by West Nile virus (WNV) and Zika virus (ZIKV)-infected mosquitoes with three assays to compare detection rates and the limit of detection for each platform with respect to virus detection of a single infected mosquito and quantify the time interval of virus preservation on the cards...
February 15, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29461414/validity-and-reliability-of-an-on-court-fitness-test-for-assessing-and-monitoring-aerobic-fitness-in-squash
#8
Carl Alexander James, Florencio Tenllado Vallejo, Melvin Kantebeen, Saro Farra
Current on-court assessments of aerobic fitness in squash are not designed to yield a wealth of physiological data. Moreover, tests may require complex computer equipment or involve simulated racket strokes, which are difficult to standardize at high intensities. This study investigated the validity and reliability of a squash-specific fitness test which can yield both a standalone performance score, as well as pertinent physiological markers such as V[Combining Dot Above]O2max, the lactate turnpoint and oxygen cost, in a sport-specific environment...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29459856/the-immune-and-non-immune-pathways-that-drive-chronic-gastrointestinal-helminth-burdens-in-the-wild
#9
Simon A Babayan, Wei Liu, Graham Hamilton, Elizabeth Kilbride, Evelyn C Rynkiewicz, Melanie Clerc, Amy B Pedersen
Parasitic helminths are extremely resilient in their ability to maintain chronic infection burdens despite (or maybe because of) their hosts' immune response. Explaining how parasites maintain these lifelong infections, identifying the protective immune mechanisms that regulate helminth infection burdens, and designing prophylactics and therapeutics that combat helminth infection, while preserving host health requires a far better understanding of how the immune system functions in natural habitats than we have at present...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29459131/perfluoroalkyl-substances-glucose-homeostasis-and-gestational-diabetes-mellitus-in-chinese-pregnant-women-a-repeat-measurement-based-prospective-study
#10
Hexing Wang, Jiaqi Yang, Hongyi Du, Linji Xu, Shuping Liu, Jianping Yi, Xu Qian, Yue Chen, Qingwu Jiang, Gengsheng He
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) can affect glucose homeostasis and has been suggested as a potential risk of diabetes mellitus, but data are limited for pregnant women. OBJECTIVES: We aimed to explore the associations of exposure to PFASs with glucose homeostasis and gestational diabetes mellitus (GDM) in Chinese pregnant women. METHODS: The current study was conducted in Hebei Province of Northern China between 2013 and 2014 and 560 pregnant women were recruited in their early term of pregnancy and two representative serum PFASs, perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), were measured...
February 16, 2018: Environment International
https://www.readbyqxmd.com/read/29457317/effects-of-alcohol-intoxication-on-self-reported-drinking-patterns-expectancies-motives-and-personality-a-randomized-controlled-experimental-study
#11
Sören Kuitunen-Paul, Elisabeth Obst, Ruth Schmidt, Christian Sommer, Paula T Kuitunen, Hans-Ulrich Wittchen, Ulrich S Zimmermann
Alcohol intoxication may affect self-reports of alcohol use and related constructs, such as impulsivity and dependence symptoms. Improved knowledge about potential systematic reporting biases induced by alcohol, e.g. through disinhibition, may be relevant for the assessment of intoxicated individuals both in clinical routine and research. We therefore randomly assigned 54 socially drinking males aged 18 to 19 without lifetime diagnosis of DSM-IV alcohol dependence to one of two experimental arms: either placebo infusion at day 1 and alcohol infusion at day 2, or vice versa...
February 19, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29457022/a-case-report-of-compound-heterozygous-cyp24a1-mutations-leading-to-nephrolithiasis-successfully-treated-with-ketoconazole
#12
Emma Davidson Peiris, Raghav Wusirika
CYP24A1 is an enzyme that inactivates vitamin D. Loss-of-function mutations in this enzyme are rare but have been linked with idiopathic infantile hypercalcemia as well as adult-onset nephrocalcinosis and nephrolithiasis. Genetic testing for this mutation should be considered in the presence of calciuria, elevated serum calcium, elevated 1,25-dihydroxyvitamin D, and suppressed parathyroid hormone. We present a case with these lab findings as well as an elevated 25-hydroxyvitamin D/24,25-dihydroxyvitamin D ratio in whom compound heterozygous CYP24A1 mutations were found...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29456811/-in-vivo-activity-assessment-of-some-tanacetum-species-used-as-traditional-wound-healer-along-with-identification-of-the-phytochemical-profile-by-a-new-validated-hplc-method
#13
Serkan Özbilgin, Esra Küpeli Akkol, Burçin Ergene Öz, Mert Ilhan, Gülçin Saltan, Özlem Bahadır Acıkara, Mehmet Tekin, Hikmet Keleş, Ipek Süntar
Objectives: Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo wound-healing and anti-inflammatory potential of four Tanacetum species, Tanacetum argenteum (Lam.) Willd. subsp. argenteum (TA) , Tanacetum heterotomum (Bornm.) Grierson (TH), Tanacetum densum (Lab.) Schultz Bip. subsp. sivasicum (TD), and Tanacetum vulgare L. (TV) was investigated. Materials and Methods: The chloroform (CHCl3 ) and methanol:water (80:20) extracts were prepared from the aerial parts of each plant...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29455024/all-carbon-suspended-nanowire-sensors-as-a-rapid-highly-sensitive-label-free-chemiresistive-biosensing-platform
#14
Aung Thiha, Fatimah Ibrahim, Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Kwai Lin Thong, Bey Fen Leo, Marc Madou
Nanowire sensors offer great potential as highly sensitive electrochemical and electronic biosensors because of their small size, high aspect ratios, and electronic properties. Nevertheless, the available methods to fabricate carbon nanowires in a controlled manner remain limited to expensive techniques. This paper presents a simple fabrication technique for sub-100 nm suspended carbon nanowire sensors by integrating electrospinning and photolithography techniques. Carbon Microelectromechanical Systems (C-MEMS) fabrication techniques allow fabrication of high aspect ratio carbon structures by patterning photoresist polymers into desired shapes and subsequent carbonization of resultant structures by pyrolysis...
February 9, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454976/defective-endogenous-pain-modulation-in-fibromyalgia-a-meta-analysis-of-temporal-summation-and-conditioned-pain-modulation-paradigms
#15
REVIEW
Anthony Terrence O'Brien, Alicia Deitos, Yolanda Triñanes Pego, Felipe Fregni, Maria Teresa Carrillo-de-la-Peña
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients to healthy controls. We computed Hedge's g, risk of bias, sensitivity analysis and meta-regression tests with 10000 Monte-Carlo permutations. Twenty-three studies (625 female/23 male FM patients and 591 female/81 male healthy controls) were included. The meta-analyses showed an effect size of 0...
February 15, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29454922/nutrient-recovery-from-wastewater-through-pilot-scale-electrodialysis
#16
Andrew J Ward, Kimmo Arola, Emma Thompson Brewster, Chirag M Mehta, Damien J Batstone
Nutrient recovery performance utilising an electrodialysis (ED) process was quantified in a 30-cell pair pilot reactor with a 7.2 m2 effective membrane area, utilising domestic anaerobic digester supernatant, which had been passed through a centrifuge as a feed source (centrate). A concentrated product (NH4 -N 7100 ± 300 mg/L and K 2490 ± 40 mg/L) could be achieved by concentrating nutrient ions from the centrate wastewater dilute feed stream to the product stream using the ED process. The average total current efficiency for all major cations over the experimental period was 76 ± 2% (NH4 -N transport 40%, K transport 14%)...
February 8, 2018: Water Research
https://www.readbyqxmd.com/read/29454197/cigarette-butts-may-have-low-toxicity-to-soil-dwelling-invertebrates-evidence-from-a-land-snail
#17
Hussan Gill, Kyler Rogers, Bilal Rehman, John Moynihan, Elizabeth A Bergey
Cigarette butts are a common form of litter that is often deposited on soil, where toxins from butts may affect soil-dwelling organisms. We examined possible toxicity of cigarette butts to the woodland snail Anguispira alternata using a toxicity study with cigarette butt effluent and a lab-based habitat choice experiment in which snails could feed or rest on areas with different butt densities. No mortality occurred during the 32-day toxicity study, which used six effluent concentrations ranging from 0 to 4butts/l (0 to 0...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453636/assessment-of-oximetry-based-statistical-classifiers-as-simplified-screening-tools-in-the-management-of-childhood-obstructive-sleep-apnea
#18
Andrea Crespo, Daniel Álvarez, Leila Kheirandish-Gozal, Gonzalo C Gutiérrez-Tobal, Ana Cerezo-Hernández, David Gozal, Roberto Hornero, Félix Del Campo
PURPOSE: A variety of statistical models based on overnight oximetry has been proposed to simplify the detection of children with suspected obstructive sleep apnea syndrome (OSAS). Despite the usefulness reported, additional thorough comparative analyses are required. This study was aimed at assessing common binary classification models from oximetry for the detection of childhood OSAS. METHODS: Overnight oximetry recordings from 176 children referred for clinical suspicion of OSAS were acquired during in-lab polysomnography...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453130/charting-the-development-of-cognitive-mapping
#19
Alina Nazareth, Steven M Weisberg, Katherine Margulis, Nora S Newcombe
Developmental research beginning in the 1970s has suggested that children's ability to form cognitive maps reaches adult levels during early adolescence. However, this research has used a variety of testing procedures, often in real-world environments, which have been difficult to share widely across labs and to use to probe components of mapping, individual differences in success, and possible mechanisms of development and reasons for individual variation. In this study, we charted the development of cognitive mapping using a virtual navigation paradigm, Silcton, that allows for testing samples of substantial size in a uniform way and in which adults show marked individual differences in the formation of accurate route representations and/or in route integration...
February 13, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29452016/the-effect-of-rap-hip-hop-music-on-young-adult-smoking-an-experimental-study
#20
Zeena Harakeh, Tom F M Ter Bogt
BACKGROUND: Music may influence young people's behavior through its lyrics. Substance use references occur more frequently in rap/hip-hop than in other music genres. OBJECTIVES: The aim was to examine whether the exposure to rap/hip-hop lyrics referring to substance use affected cigarette smoking. METHODS: An experiment with a 3-group between subject design was conducted among 74 daily-smoking young adults ranging in age from 17 to 25 years old...
February 16, 2018: Substance Use & Misuse
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