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https://www.readbyqxmd.com/read/29328798/the-early-days-of-surgery-for-cardiac-injuries
#1
Harold Ellis
Over many centuries, wounds of the heart were thought to be fatal. With the introduction of first anaesthesia and then antiseptic surgery in the second half of the 19th century, there was an explosion in surgery; the abdominal cavity, the chest, the skull were explored and operated upon and yet the heart was considered to be a 'no go' region of the body. One of the greatest and most innovative surgeons of that time, Theodor Billroth of Vienna, who must be considered one of the fathers of modern surgery, with pioneering work on many parts of the body, wrote: 'The surgeon who attempts to suture a wound of the heart should lose the respect of his colleagues'...
November 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29316936/perioperative-complications-after-surgical-treatment-in-degenerative-adult-de-novo-scoliosis
#2
Maciej J K Simon, Henry F H Halm, Markus Quante
BACKGROUND: Degenerative adult de novo (DAD) scoliosis appears characteristically in the sixth or seventh decade with symptoms of severe back pain and radiculopathy or spinal claudication. The aim of this study was to enhance the knowledge of perioperative complications and detect possible risk factors in this selective DAD scoliosis surgery. METHODS: This retrospective study included only patients with DAD scoliosis undergone correction spondylodesis with previous failure of conservative treatment...
January 10, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29304832/dalbavancin-treatment-in-a-deep-sternal-wound-mrsa-infection-after-coronary-artery-bypass-surgery-a-case-report
#3
Aneta Guzek, Grzegorz Suwalski, Dariusz Tomaszewski, Zbigniew Rybicki
BACKGROUND: A deep sternal wound infection (DSWI) can become a severe complication after cardiac surgery, with in-hospital mortality rates reaching up to 35%. Staphylococci, particularly methicillin resistant Staphylococcus aureus (MRSA), play important roles in its etiology. CASE PRESENTATION: This case report presents a patient who underwent coronary artery bypass surgery, and suffered postoperatively from a DSWI caused by MRSA. The pathogen was susceptible to vancomycin and rifampicin in vitro; however, this therapy was clinically ineffective...
January 5, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29303551/engineering-bioinspired-antioxidant-materials-promoting-cardiomyocyte-functionality-and-maturation-for-tissue-engineering-application
#4
Parvaiz Ahmad Shiekh, Anamika Singh, Ashok Kumar
Oxidative stress plays an important role in various pathological conditions such as wound healing, inflammation, myocardial infarction and biocompatibility of the materials. Antioxidant polymers to attenuate oxidative stress is an emerging field of biomaterial research with a huge impact in the field of tissue engineering and regenerative medicine. We describe here the fabrication and evaluation of an elastomeric antioxidant polyurethane (PUAO) for tissue engineering applications. Uniaxial and cyclic tensile testing, thermal analysis, degradation, cytotoxicity and antioxidant analysis was carried out...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29289957/surgical-treatment-of-cardiac-tumors-insights-from-an-18-year-single-center-analysis
#5
Sabreen Mkalaluh, Marcin Szczechowicz, Saeed Torabi, Bastian Schmack, Anton Sabashnikov, Bashar Dib, Matthias Karck, Alexander Weymann
BACKGROUND The aim of this study was to investigate the clinical presentation, operative data, and early and late outcomes of a large patient cohort undergoing surgical treatment for cardiac tumors in our institution. MATERIAL AND METHODS A total of 181 patients underwent surgery because of suspected cardiac tumor in our institution between 1998 and 2016. In 162 cases, the diagnosis was confirmed postoperatively and these patients were included in this study. Preoperative baseline characteristics, operative data, and postoperative early and long-term outcomes were analyzed...
December 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29286452/esophageal-heat-transfer-for-patient-temperature-control-and-targeted-temperature-management
#6
Melissa I Naiman, Maria Gray, Joseph Haymore, Ahmed F Hegazy, Andrej Markota, Neeraj Badjatia, Erik B Kulstad
Controlling patient temperature is important for a wide variety of clinical conditions. Cooling to normal or below normal body temperature is often performed for neuroprotection after ischemic insult (e.g. hemorrhagic stroke, subarachnoid hemorrhage, cardiac arrest, or other hypoxic injury). Cooling from febrile states treats fever and reduces the negative effects of hyperthermia on injured neurons. Patients are warmed in the operating room to prevent inadvertent perioperative hypothermia, which is known to cause increased blood loss, wound infections, and myocardial injury, while also prolonging recovery time...
November 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29286107/kinetic-alterations-of-collagen-and-elastic-fibres-and-their-association-with-cardiac-function-in-acute-myocardial-infarction
#7
Yuexin Yu, Guotian Yin, Shisan Bao, Zhikun Guo
The present study aimed to investigate kinetic alterations of collagen and elastic fibres and their association with cardiac function in the acute myocardial infarction (AMI) heart. AMI was generated in Sprague-Dawley rats by ligation of the left anterior descending coronary artery. Cardiac function was determined using B‑ultrasonography, AMI was verified using histopathology. The kinetics of collagen type I/III and elastic fibre were evaluated using immunohistochemistry and western blotting at 1 week (1 w), 2 weeks (2 w), 3 weeks (3 w) and 4 weeks (4 w) post‑AMI...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29283063/antiplatelet-potential-of-plant-derived-glycosides-as-possible-lead-compounds
#8
Haroon Khan, Aini Pervaiz, Mohammad A Kamal, Seema Patel
Blood platelets are crucial for maintaining hemostasis and several events in the wound-healing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin and warfarin. since a long time. But some adverse reactions like aspirin resistance and bleed disorders cause patient in compliance and reduce their therapeutic potential. Thus, the search for potent and safer antiplatelet agents is of great interest...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29249501/predictors-of-survival-in-octogenarians-after-mitral-valve-surgery-for-degenerative-disease-the-mitral-surgery-in-octogenarians-study
#9
Pierpaolo Chivasso, Vito D Bruno, Shakil Farid, Pietro Giorgio Malvindi, Amit Modi, Umberto Benedetto, Franco Ciulli, Yasir Abu-Omar, Massimo Caputo, Gianni D Angelini, Steve Livesey, Hunaid A Vohra
OBJECTIVES: An increasing number of octogenarians are referred to undergo mitral valve surgery for degenerative disease, and percutaneous approaches are being increasingly used in this subgroup of patients. We sought to determine the survival and its predictors after Mitral valve Surgery in Octogenarians (MiSO) in a multicenter UK study of high-volume specialized centers. METHODS: Pooled data from 3 centers were collected retrospectively. To identify the predictors of short-term composite outcome of 30 days mortality, acute kidney injury, and cerebrovascular accident, a multivariable logistic regression model was developed...
November 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29249425/evidence-for-functional-par-4-thrombin-receptor-expression-in-cardiac-fibroblasts-and-its-regulation-by-high-glucose-par-4-in-cardiac-fibroblasts
#10
Sonja Kleeschulte, Johann Jerrentrup, Daniel Gorski, Joachim Schmitt, Anke C Fender
BACKGROUND: Thrombin promotes cardiac fibroblast proliferation and fibrosis via protease-activated receptor (PAR-1). PAR-4 is reportedly absent in cardiac fibroblasts. In smooth muscle cells, PAR-4 expression is also low but increases upon hyperglycemia and contributes to vascular remodelling in diabetic mice. We examined if PAR-4 is a glucose-responsive gene with remodelling-related functions in cardiac fibroblasts. METHODS AND RESULTS: Cardiac PAR-4 increased in mice with streptozotocin- or diabetogenic diet (DD)-induced diabetes...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29248284/cost-of-individual-complications-following-coronary-artery-bypass-grafting
#11
J Hunter Mehaffey, Robert B Hawkins, Matthew Byler, Eric J Charles, Clifford Fonner, Irving Kron, Mohammed Quader, Alan Speir, Jeff Rich, Gorav Ailawadi
OBJECTIVE: The financial implications of postoperative complications in cardiac surgery remain poorly understood. The purpose of this study was to define the cost of surgery without complications and demonstrate the incremental cost of each complication. METHODS: All patients undergoing isolated coronary artery bypass grafting (CABG) were evaluated (2006-2015) from a statewide Society of Thoracic Surgeons database collaborative (N = 36,588). Patients were stratified by presence of postoperative complications, including major morbidities as defined by the Society of Thoracic Surgeons (ie, prolonged ventilation, renal failure, reoperation, stroke, and deep sternal wound infection)...
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29248268/trifluoroacetic-acid-three-times-the-fluoride-three-times-the-toxicity
#12
Christie Sun, Bryan Corbett
Trifluoroacetic acid (TFAA) is a carboxylic acid, similar to acetic acid, used industrially and in laboratories. There is a paucity of data regarding exposure and the concern is that toxicity may mimic that of hydrofluoric acid (HF), causing electrolyte abnormalities, dysrhythmia, and cardiac arrest. We report a case of a 27-year-old male that presents with a dermal exposure to TFAA. His exam was remarkable for a 4% body surface area partial thickness burn to the right forearm. There were no initial electrolyte abnormalities or dysrhythmias and the patient was admitted to telemetry monitoring overnight...
December 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29247693/understanding-cardiac-extracellular-matrix-remodeling-to-develop-biomarkers-of-myocardial-infarction-outcomes
#13
REVIEW
Signe Holm Nielsen, Alan J Mouton, Kristine Y DeLeon-Pennell, Federica Genovese, Morten Karsdal, Merry L Lindsey
Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure...
December 13, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29245279/mitral-regurgitation-after-anthracycline-based-chemotherapy-in-an-adult-patient-with-breast-cancer-a-case-report
#14
Xiaoyan Liu, Yanlin Zhu, Xue Lin, Ligang Fang, Xiaowei Yan
RATIONALE: Anthracyclines cardiotoxicity characterized by dilated myocardiopathy has been well described in the literature. However, anthracyclines-induced valvular diseases have been seldom reported. PATIENT CONCERNS: In this study, we present the case of a 62-year-old Chinese female patient with breast cancer developing severe mitral regurgitation after anthracycline exposure. DIAGNOSES: The patient was diagnosed with mitral regurgitation with preserved left ventricular ejection fraction and normal cardiac chamber dimensions in the sixth month after the last course of anthracycline-containing chemotherapy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241963/negative-pressure-wound-therapy-in-pediatric-surgery-how-and-when-to-use
#15
REVIEW
Lisieux Eyer de Jesus, Alana Bandeira Martins, Pablo Baptista Oliveira, Fernanda Gomes, Thais Leve, Samuel Dekermacher
INTRODUCTION: Negative pressure wound therapy (NPWT) has been widely adopted to treat laparostomy, abdominal compartment syndrome (ACS) and complicated wounds associated with tissue loss. The method presents specific aspects, advantages and indications in Pediatrics. Our aim is to review the evidence available about NPWT in children. METHODS: Active search for papers about NPWT in Pediatric patients. Papers referring to orthopedic problems, wound complications after Cardiac Surgery or burns were excluded...
November 21, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29238641/complication-rates-in-posterior-lumbar-interbody-fusion-plif-surgery-with-human-bone-morphogenetic-protein-2-medicare-population
#16
Raed Alobaidaan, Jeremiah R Cohen, Elizabeth L Lord, Zorica Buser, S Tim Yoon, Jim A Youssef, Jong-Beom Park, Darrel S Brodke, Jeffrey C Wang, Hans-Joerg Meisel
Study Design: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. Objective: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the "off-label" manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29238634/asa-classification-as-a-risk-stratification-tool-in-adult-spinal-deformity-surgery-a-study-of-5805-patients
#17
Sulaiman Somani, John Di Capua, Jun S Kim, Kevin Phan, Nathan J Lee, Parth Kothari, Joung-Heon Kim, James Dowdell, Samuel K Cho
Study Design: Retrospective analysis of prospectively collected data. Objectives: Adult spinal deformity (ASD) surgery is a highly complex procedure that has high complication rates. Risk stratification tools can improve patient management and may lower complication rates and associated costs. The goal of this study was to identify the independent association between American Society of Anesthesiologists (ASA) class and postoperative outcomes following ASD surgery...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237016/evaluation-of-cefazolin-antimicrobial-prophylaxis-during-cardiac-surgery-with-cardiopulmonary-bypass
#18
Divna Calic, Robert E Ariano, Rakesh C Arora, Hilary P Grocott, Ted M Lakowski, Ryan Lillico, Sheryl A Zelenitsky
Objectives: Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether adequate concentrations are achieved in this patient population. The goal of our study was to characterize intraoperative cefazolin concentrations particularly at wound closure with regards to maintaining target cefazolin closure concentrations ≥40 mg/L. Methods: Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB) and receiving cefazolin AP according to protocol were studied...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29234365/ethnopharmacological-uses-phytochemistry-and-pharmacological-properties-of-croton-macrostachyus-hochst-ex-delile-a-comprehensive-review
#19
REVIEW
Alfred Maroyi
Croton macrostachyus is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. macrostachyus as herbal medicine, the phytochemistry, and pharmacological properties of its parts used as herbal medicines are reviewed. The extensive literature survey revealed that C. macrostachyus is traditionally used to treat or manage at least 81 human and animal diseases and ailments. The species is used as herbal medicine for diseases and ailments such as abdominal pains, cancer, gastrointestinal disorders, malaria, pneumonia, sexually transmitted infections, skin infections, typhoid, and wounds and as ethnoveterinary medicine...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229038/the-opportunities-and-limitations-of-minimally-invasive-cardiac-surgery
#20
Torsten Doenst, Mahmoud Diab, Christoph Sponholz, Michael Bauer, Gloria Färber
BACKGROUND: Over the past two decades, minimally invasive techniques for classic heart valve surgery and isolated bypass surgery have been developed that enable access to the heart via partial sternotomy for most aortic valve procedures and via sternotomy-free mini-thoracotomy for other procedures. METHODS: We review the current evidence on minimally invasive cardiac surgery on the basis of pertinent randomized studies and database studies retrieved by a selective search in the MEDLINE and PubMed Central databases, as well as by the Google Scholar search engine...
November 17, 2017: Deutsches Ärzteblatt International
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