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https://www.readbyqxmd.com/read/28526307/risk-factors-of-cardiac-device-infection-glove-contamination-during-device-procedures
#1
Isabella Kozon, Sam Riahi, Søren Lundbye-Christensen, Anna Margrethe Thøgersen, Tove Ejlertsen, Dorthe Aaen, Kirsten I Paulsen, Søren Hjortshøj
BACKGROUND: Infections in cardiac implantable electronic devices (CIEDs) constitute a serious complication. We sought to identify contamination of gloves before handling the device in primary and replacement CIED procedures. METHODS: Two groups of 30 patients underwent primary CIED implantation or replacement. Before the device entered the surgical field, surgeon and assistant imprinted their outer gloves on aerobe and anaerobe agar plates, and a wound swab was performed...
May 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28516670/endoscopic-versus-open-radial-artery-harvesting-a-meta-analysis-of-randomized-controlled-and-propensity-matched-studies
#2
Mohamed Rahouma, Mohamed Kamel, Umberto Benedetto, Lucas B Ohmes, Antonino Di Franco, Christopher Lau, Leonard N Girardi, Robert F Tranbaugh, Fabio Barili, Mario Gaudino
BACKGROUND: We sought to investigate the impact of radial artery harvesting techniques on clinical outcomes using a meta-analytic approach limited to randomized controlled trials and propensity-matched studies for clinical outcomes, in which graft patency was analyzed. METHODS: A systematic literature review was conducted using PubMed and MEDLINE to identify publications containing comparisons between endoscopic radial artery harvesting (ERAH) and open harvesting (ORAH)...
May 17, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28516472/nasal-decontamination-for-the-prevention-of-surgical-site-infection-in-staphylococcus-aureus-carriers
#3
REVIEW
Zhenmi Liu, Gill Norman, Zipporah Iheozor-Ejiofor, Jason Kf Wong, Emma J Crosbie, Peter Wilson
BACKGROUND: Surgical site infection rates in the month following surgery vary from 1% to 5%. Due to the large number of surgical procedures conducted annually, the costs of these surgical site infections (SSIs) can be considerable in financial and social terms. Nasal decontamination using antibiotics or antiseptics is performed to reduce the risk of SSIs by preventing organisms from the nasal cavity being transferred to the skin where a surgical incision will be made. Staphylococcus aureus (S aureus) colonises the nasal cavity and skin of carriers and can cause infection in open or unhealed surgical wounds...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28506218/investigation-of-the-pathophysiology-of-cardiopulmonary-bypass-using-rodent-extracorporeal-life-support-model
#4
Ru-Wen Chang, Chien-Ming Luo, Hsi-Yu Yu, Yih-Sharng Chen, Chih-Hsien Wang
BACKGROUND: Extracorporeal life support (ECLS) systems are life-saving devices used for treating patients with severe cardiopulmonary failure. In this study, we implemented a rat model of ECLS without the administration of inotropes or vasopressors. METHODS: The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min. The right external jugular vein and right femoral artery were separately cannulated to the ECLS outflow and inflow, respectively...
May 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28502551/variation-in-hospital-costs-and-reimbursement-for-endovascular-aneurysm-repair-a-vascular-quality-initiative-pilot-project
#5
Gary W Lemmon, Dan Neal, Randall R DeMartino, Joseph R Schneider, Tej Singh, Larry Kraiss, Salvatore Scali, Apostolos Tassiopoulos, Andrew Hoel, Jack L Cronenwett
OBJECTIVE: Comparing costs between centers is difficult because of the heterogeneity of vascular procedures contained in broad diagnosis-related group (DRG) billing categories. The purpose of this pilot project was to develop a mechanism to merge Vascular Quality Initiative (VQI) clinical data with hospital billing data to allow more accurate cost and reimbursement comparison for endovascular aneurysm repair (EVAR) procedures across centers. METHODS: Eighteen VQI centers volunteered to submit UB04 billing data for 782 primary, elective infrarenal EVAR procedures performed by 108 surgeons in 2014...
May 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28501899/is-there-a-july-effect-in-pediatric-neurosurgery
#6
Yimo Lin, Rory R Mayer, Terence Verla, Jeffrey S Raskin, Sandi Lam
PURPOSE: The belief that July, when resident physicians' training year begins, may be associated with increased risk of patient morbidity and mortality is known as the "July effect." This study aimed to compare complication rates after pediatric neurosurgical procedures in the first versus last academic quarters in two national datasets. METHODS: Data were extracted from the National Surgical Quality Improvement Program-Pediatrics (NSQIP-P) database for year 2012 for 30-day complication events and the Kids' Inpatient Database (KID) for year 2012 for in-hospital complication events after pediatric neurosurgical procedures...
May 13, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28501566/dna-methylation-regulated-gene-expression-in-organ-fibrosis
#7
REVIEW
Xiangyu Zhang, Min Hu, Xing Lyu, Chun Li, Victor J Thannickal, Yan Y Sanders
DNA methylation is a major epigenetic mechanism to regulate gene expression. Epigenetic regulation, including DNA methylation, histone modifications and RNA interference, results in heritable changes in gene expression independent of alterations in DNA sequence. Epigenetic regulation often occurs in response to aging and environment stimuli, including exposures and diet. Studies have shown that DNA methylation is critical in the pathogenesis of fibrosis involving multiple organs sytems, contributing to significant morbidity and mortality...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28494457/resveratrol-protects-against-pulmonary-arterial-hypertension-in-rats-via-activation-of-silent-information-regulator-1
#8
Lei Yu, Yingfeng Tu, Xueling Jia, Kun Fang, Li Liu, Lin Wan, Chuanying Xiang, Yanan Wang, Xiangju Sun, Tianyou Liu, Dejun Yu, Weiwei Cao, Yinli Song, Yuhua Fan
BACKGROUND/OBJECTIVES: The polyphenol resveratrol (Rev) has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH). The present study was designed to investigate the action and potential mechanism of Rev on PAH, focusing on the role of SIRT1 (Silent Information Regulator 1) in apoptosis of pulmonary artery smooth muscle cells (PASMCs). METHODS: PAH rats were established by exposure to hypoxia for 21 days. Rev and SRT1720 (a selective SIRT1 activator) were used to reverse PAH by gavaging rats...
May 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28492792/cervical-cannulation-for-surgical-repair-of-congenital-cardiac-defects-in-infants-and-small-children
#9
Pankaj Garg, Arvind Kumar Bishnoi, Ketav Lakhia, Parth Solanki, Jigar Surti, Komal Shah, Sanjay Patel
INTRODUCTION: The biggest challenge faced in minimally invasive pediatric cardiac surgery is cannulation for cardiopulmonary bypass. Our technique and experience of cervical cannulation in infants and small children for repair of congenital cardiac defects is reported in this study. METHODS: From January 2013 to June 2015, 37 children (22 males) with mean age of 17.97±8.63 months and weight of 8.06±1.59 kg were operated on for congenital cardiac defects through right lateral thoracotomy...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28486627/re-exploration-due-to-bleeding-is-not-associated-with-severe-postoperative-complications
#10
Sandeep P Tambe, Hans-Henrik Kimose, Jakob Raben Greisen, Carl-Johan Jakobsen
OBJECTIVES: In cardiac surgery, postoperative bleeding remains a frequent complication with various possible adverse outcomes. Re-exploration due to bleeding is frequent in this type of patient. Sternal wound infection is an infrequent but serious and devastating complication. Whether re-exploration due to bleeding significantly affects the incidence of sternal wound infection is uncertain. There is no consensus on allowed severity of bleeding and timing of intervention. METHODS: A retrospective, observational cohort study of 15 350 consecutive patients who underwent cardiac surgical procedures from 1 April 2006 through 31 December 2013 in 3 different university hospitals in Denmark was performed...
May 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28486563/in-vitro-induction-of-netosis-comprehensive-live-imaging-comparison-and-systematic-review
#11
Tamara Hoppenbrouwers, Anouchska S A Autar, Andi R Sultan, Tsion E Abraham, Wiggert A van Cappellen, Adriaan B Houtsmuller, Willem J B van Wamel, Heleen M M van Beusekom, Johan W van Neck, Moniek P M de Maat
BACKGROUND: Multiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a standardized in vitro study of NETosis inducers important in (cardiac) wound healing. METHODS: In vitro NETosis was studied by incubating neutrophils with PMA, living and dead bacteria (S. aureus and E. coli), LPS, (activated) platelets (supernatant), glucose and calcium ionophore Ionomycin using 3-hour periods of time-lapse confocal imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28486324/case-report-and-review-of-management-of-penetrating-trauma-and-cardiac-pericarditis
#12
Elizabeth Thomas, Pamela Golden, Vicki Moran
Acute pericarditis is the most common form of pericardial disease worldwide and it has many potential etiologies. This case study examines a patient admitted for multiple gunshot wounds who developed acute pericarditis postpericardial drain removal. The initial penetrating abdominal trauma, along with facial injuries and a suspected myocardial infarction, led to confusion in which the initial etiology of pericarditis was missed, creating a delay in overall patient care and extended length of stay.
May 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28486091/angiotensin-receptors-in-dupuytren-s-disease-a-target-for-pharmacological-treatment
#13
Christopher Stephen, Leila Touil, Partha Vaiude, Jaipaul Singh, Stuart McKirdy
BACKGROUND: Attempts at the pharmacological treatment of Dupuytren's disease have so far been unsuccessful, and the disease is not yet fully understood on a cellular level. The Renin-Angiotensin System has long been understood to play a circulating hormonal role. However, there is much evidence showing Angiotensin II to play a local role in wound healing and fibrosis, with ACE inhibitors being widely used as an anti-fibrotic agent in renal and cardiac disease. METHODS: This study was designed to investigate the presence of Angiotensin II receptors 1 (AT1) and 2 (AT2) in Dupuytren's tissue to form a basis for further study into the pharmacological treatment of this condition...
May 9, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28483631/a-retrospective-analysis-of-surgical-femoral-artery-closure-techniques-conventional-vs-purse-suture-technique
#14
Mehmet Cakici, Levent Yazicioglu, Cagdas Baran, Evren Ozcinar, Alper Ozgur, Canan Soykan, Sadik Eryilmaz, Sadik Bilgiç, Bulent Kaya, A Ruchan Akar
INTRODUCTION: Different techniques have been reported for the exploration and repair of femoral artery (FA) in patients who undergo minimally invasive cardiac surgery (MICS) and endovascular aortic surgery. We used a modified approach alternative to the conventional technique (group CT) since May 2013, which specifies a shorter groin incision and diamond shaped hemostatic purse sutures for arteriotomy closure without the requirement of cross-clamping (group PT) and evaluated early outcomes and the complication profiles of the two techniques for femoral access...
May 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28482805/management-of-potentially-life-threatening-emergencies-at-74-primary-level-hospitals-in-mongolia-results-of-a-prospective-observational-multicenter-study
#15
Naranpurev Mendsaikhan, Davaa Gombo, Ganbold Lundeg, Christian Schmittinger, Martin W Dünser
BACKGROUND: While the capacities to care for and epidemiology of emergency and critically ill patients have been reported for secondary and tertiary level hospitals in Mongolia, no data exist for Mongolian primary level hospitals. METHODS: In this prospective, observational multicenter study, 74 primary level hospitals of Mongolia were included. We determined the capacities of these hospitals to manage medical emergencies. Furthermore, characteristics of patients presenting with potentially life-threatening emergencies to these hospitals were evaluated during a 6 month period...
May 8, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28476435/a-multi-institutional-analysis-of-trimodality-therapy-for-esophageal-cancer-in-elderly-patients
#16
Scott C Lester, Steven H Lin, Michael Chuong, Neha Bhooshan, Zhongxing Liao, Andrea L Arnett, Sarah E James, Jaden D Evans, Grant M Spears, Ritsuko Komaki, Michael G Haddock, Minesh P Mehta, Christopher L Hallemeier, Kenneth W Merrell
PURPOSE: The therapeutic gains of neoadjuvant chemoradiation therapy (nCRT) followed by esophagectomy may be offset by increased incidences of morbidity and mortality in elderly patients. This study aimed to determine the impact of age on the risks and benefits of trimodality therapy for esophageal cancer. METHODS AND MATERIALS: We evaluated 571 patients treated with trimodality therapy at 3 high-volume tertiary cancer centers in the United States from 2007 to 2013...
February 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28464893/anticancer-potential-of-thevetia-peruviana-fruit-methanolic-extract
#17
Alberto Ramos-Silva, Faviola Tavares-Carreón, Mario Figueroa, Susana De la Torre-Zavala, Argel Gastelum-Arellanez, Aída Rodríguez-García, Luis J Galán-Wong, Hamlet Avilés-Arnaut
BACKGROUND: Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.) Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native to Mexico and Central America, is a medicinal plant used traditionally to cure diseases like ulcers, scabies, hemorrhoids and dissolve tumors. The purpose of this study was to evaluate the cytotoxic, antiproliferative and apoptotic activity of methanolic extract of T. peruviana fruits on human cancer cell lines. METHODS: The cytotoxic activity of T...
May 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28460201/deep-sternal-wound-infections-a-severe-complication-after-cardiac-surgery
#18
A Morgante, F Romeo
Sternal Wound Infections (SWI) represent a dangerous complication after cardiac surgery entailing significantly longer hospital stays and worse short-term survival, especially in case of deep infections (DSWI) with the onset of osteomielitis or mediastinitis. The real incidence of SWI can be estimated between 0.25% and 10%; among the risk factors for sternal dehiscences after a longitudinal median sternotomy, several experiences underline the role of diabetes as an independent risk factor for post-operative infections, especially in patients affected by COPD with higher BMI...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28458959/preoperative-radiotherapy-is-not-associated-with-increased-post-mastectomy-short-term-morbidity-analysis-of-77-902-patients
#19
Pablo A Baltodano, Myrna Eliann Reinhardt, José M Flores, Francis M Abreu, Anmol Chattha, Lyonell Kone, Carisa M Cooney, Michele A Manahan, Richard C Zellars, Gedge D Rosson
BACKGROUND: Neoadjuvant radiotherapy (NRT) enhances breast-conserving surgery outcomes, reducing local recurrence of breast cancer and increasing median survival. However, its effect on postoperative morbidity remains under-studied. We sought to assess the impact of NRT on 30-day postoperative morbidity after mastectomy. METHODS: We analyzed data from women undergoing mastectomy (with or without immediate reconstruction) using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) 2005-2011 datasets...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28458765/right-ventricular-perforation-from-a-floating-rib-following-deep-sternal-wound-infection-debridement-and-application-of-a-vacuum-assisted-closure-device-a-case-report-and-literature-review
#20
Amanda J Ross, Nada N Berry
Introduction: Deep sternal wound infection following major cardiac surgery is a deleterious complication with sequelae that can be life threatening. The use of vacuum-assisted closure therapy in management of sternal wounds with resultant right ventricular rupture has been documented in the cardiothoracic and to a lesser extent in the reconstructive literature. Methods/Case Report: We present a case of a 67-year-old male patient who suffered from right ventricular perforation from a floating rib following debridement of a deep sternal wound infection and placement of a vacuum-assisted closure device...
2017: Eplasty
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