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https://www.readbyqxmd.com/read/27923192/regional-homogeneity-associated-with-overgeneral-autobiographical-memory-of-first-episode-treatment-naive-patients-with-major-depressive-disorder-in-the-orbitofrontal-cortex-a-resting-state-fmri-study
#1
Yansong Liu, Xudong Zhao, Zaohuo Cheng, Fuquan Zhang, Jun Chang, Haosen Wang, Rukui Xie, Zhiqiang Wang, Leiming Cao, Guoqiang Wang
BACKGROUND: Overgeneral autobiographical memory (OGM) is involved in the onset and maintenance of depression. Recent studies have shown correlations between OGM and alterations of some brain regions by using task-state functional magnetic resonance imaging (fMRI). However, the correlation between OGM and spontaneous brain activity in depression remains unclear. The purpose of this study was to determine whether patients with major depressive disorder (MDD) show abnormal regional homogeneity (ReHo) and, if so, whether the brain areas with abnormal ReHo are associated with OGM...
November 30, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27923178/aplastic-anemia-and-risk-of-deep-vein-thrombosis-and-pulmonary-embolism-a-nationwide-cohort-study
#2
Chun-Liang Lin, Cheng-Li Lin, Shu-Ling Tzeng, Wei-Sheng Chung
OBJECTIVES: Deep vein thrombosis (DVT) and pulmonary embolism (PE) constitute venous thromboembolism (VTE), which is not fully known in aplastic anemia (AA). Therefore, we investigated the incidence and risk of VTE in AA patients. METHODS: We conducted a nationwide cohort study to investigate the risk of DVT and PE in patients with AA. We identified patients with newly diagnosed AA as the AA cohort between 2000 and 2010 from the National Health Insurance Research Database (NHIRD)...
November 21, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27923175/errors-in-the-ankle-plantarflexor-force-production-are-related-to-the-gait-deficits-of-individuals-with-multiple-sclerosis
#3
Brenda L Davies, Rashelle M Hoffman, Kathleen Healey, Rana Zabad, Max J Kurz
BACKGROUND: Individuals with multiple sclerosis (MS) often have limited mobility that is thought to be due to the neuromuscular impairments of the ankle. Greater isometric motor control of the ankle has been associated with better standing postural balance but its relationship to mobility is less understood. The objectives of this investigation were to quantify the motor control of the ankle plantarflexors of individuals with MS during a dynamic isometric motor task, and explore the relationship between the ankle force control and gait alterations...
December 3, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27923174/generalized-epilepsy-syndromes-and-callosal-thickness-differential-effects-between-patients-with-juvenile-myoclonic-epilepsy-and-those-with-generalized-tonic-clonic-seizures-alone
#4
Stavroula Anastasopoulou, Florian Kurth, Eileen Luders, Ivanka Savic
PURPOSE: The definition of two well-studied genetic generalized epilepsy syndromes (GGE) - juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures alone (GTCS) - suggests the absence of structural cerebral abnormalities. Nevertheless, there are various reports of such abnormalities (especially in JME), where effects mainly occur within thalamus and mesial prefrontal regions. This raises the question of whether JME is particularly linked to midline structure abnormalities, which may also involve the corpus callosum...
November 18, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27923169/primary-stability-of-unicompartmental-knee-arthroplasty-under-dynamic-flexion-movement-in-human-femora
#5
Thomas M Grupp, Melanie Holderied, Matthias F Pietschmann, Christian Schröder, Angélica P Islas Padilla, Christoph Schilling, Volkmar Jansson, Peter E Müller
BACKGROUND: The objective of our study was to evaluate the impact of a trabecular stem fixation versus a cortical teeth fixation technique on the primary stability of cemented unicompartmental femoral components under dynamic flexion movement loading conditions in human femora. METHODS: Ten fresh-frozen human knees of a mean donor age of 73.9years were used to perform medial unicompartmental knee arthroplasty under a less invasive parapatellar surgical approach...
November 26, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27923063/control-of-gene-expression-by-rna-binding-protein-action-on-alternative-translation-initiation-sites
#6
Angela Re, Levi Waldron, Alessandro Quattrone
Transcript levels do not faithfully predict protein levels, due to post-transcriptional regulation of gene expression mediated by RNA binding proteins (RBPs) and non-coding RNAs. We developed a multivariate linear regression model integrating RBP levels and predicted RBP-mRNA regulatory interactions from matched transcript and protein datasets. RBPs significantly improved the accuracy in predicting protein abundance of a portion of the total modeled mRNAs in three panels of tissues and cells and for different methods employed in the detection of mRNA and protein...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27922918/real-time-fatigue-and-free-living-physical-activity-in-hematopoietic-stem-cell-transplantation-cancer-survivors-and-healthy-controls-a-preliminary-examination-of-the-temporal-dynamic-relationship
#7
Eileen Danaher Hacker, Inah Kim, Chang Park, Tara Peters
BACKGROUND: Fatigue and physical inactivity, critical problems facing cancer survivors, impact overall health and functioning. Our group designed a novel methodology to evaluate the temporal, dynamic patterns in real-world settings. OBJECTIVE: Using real-time technology, the temporal, dynamic relationship between real-time fatigue and free-living is described and compared in cancer survivors who were treated with hematopoietic stem cell transplantation (n = 25) and age- and gender-matched healthy controls (n = 25)...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27922857/comprehensive-assessment-of-the-arginine-pathway-and-its-relationship-to-inflammation-in-hiv
#8
Sahera Dirajlal-Fargo, S M Khurshid Alam, Abdus Sattar, Manjusha Kulkarni, Nicholas Funderburg, W H Wilson Tang, Grace A Mccomsey
BACKGROUND: Nitric oxide helps maintain vascular function and is generated through the oxidation of arginine. Whether altered arginine metabolism may lead to elevated levels of inflammation in HIV is unclear. METHODS: We performed a cross-sectional analysis of HIV-infected adults on stable ART with HIV-1 RNA < 50 copies/mL and HIV-uninfected controls. We measured biomarkers in the arginine pathway, markers of systemic inflammation, and monocyte activation. T-tests, chi-square tests and propensity score matching analyses were used to compare markers by HIV status, and multiple linear regressions were used to assess associations of arginine metabolites with markers of inflammation...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27922854/identification-of-hiv-infection-related-dna-methylation-sites-and-advanced-epigenetic-aging-in-hiv-treatment-na%C3%A3-ve-u-s-veterans
#9
Kristin N Nelson, Qin Hui, David Rimland, Ke Xu, Matthew S Freiberg, Amy C Justice, Vincent C Marconi, Yan V Sun
OBJECTIVE: HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNAm age, an aging marker involving multiple age-related CpG sites, among antiretroviral treatment (ART) naïve HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study (VACS)...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27922837/safety-of-overlapping-surgery-at-a-high-volume-referral-center
#10
Joseph A Hyder, Kristine T Hanson, Curtis B Storlie, Amy Glasgow, Nageswar R Madde, Michael J Brown, Daryl J Kor, Robert R Cima, Elizabeth B Habermann
OBJECTIVE: To compare safety profiles of overlapping and nonoverlapping surgical procedures at a large tertiary-referral center where overlapping surgery is performed. BACKGROUND: Surgical procedures are frequently performed as overlapping, wherein one surgeon is responsible for 2 procedures occurring at the same time, but critical portions are not coincident. The safety of this practice has not been characterized. METHODS: Primary analyses included elective, adult, inpatient surgical procedures from January 2013 to September 2015 available through University HealthSystem Consortium...
December 5, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27922810/impact-of-chronic-total-occlusion-revascularization-attempts-on-subsequent-clinical-outcomes
#11
Ahmad Jabbar, Georgios Christopoulos, Aris Karatasakis, Omar M Jeroudi, Georgios E Christakopoulos, Abdallah El Sabbagh, Barbara Danek, Judit Karacsonyi, Michele Roesle, Bavana V Rangan, Jerrold Grodin, Michael Luna, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We examined a contemporary, unselected cohort of patients with coronary chronic total occlusions (CTOs) to determine the impact of CTO revascularization on long-term outcomes. METHODS: We retrospectively assessed the impact of CTO revascularization on clinical outcomes of consecutive patients found to have a CTO during coronary angiography performed at our institution during 2011 and 2012. The primary endpoint was the incidence of a major adverse cardiac event (MACE, defined as a composite of death, myocardial infarction, stroke, and target-vessel revascularization [TVR])...
December 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27922752/abnormal-glucose-metabolism-and-high-energy-expenditure-in-idiopathic-pulmonary-arterial-hypertension
#12
Gustavo A Heresi, Steven K Malin, Jarrod W Barnes, Liping Tian, John P Kirwan, Raed A Dweik
RATIONALE: Insulin resistance has emerged as a potential mechanism related to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). However, direct measurements of insulin and glucose metabolism have not been performed in IPAH patients to date. OBJECTIVES: To perform comprehensive metabolic phenotyping on humans with IPAH. METHODS: We assessed plasma insulin and glucose using an oral glucose tolerance test and estimated insulin resistance and beta-cell function in 14 IPAH patients and 14 controls matched for age, sex, blood pressure, and body mass index (BMI),...
December 6, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27922580/comparative-analysis-of-peri-operative-outcomes-using-nationally-derived-hospital-discharge-data-relative-to-a-prospective-multi-center-surgical-database-of-adult-spinal-deformity-surgery
#13
Gregory W Poorman, Peter G Passias, Aaron J Buckland, Cyrus M Jalai, Michael Kelly, Daniel M Sciubba, Brian J Neuman, D Kojo Hamilton, Amit Jain, Bassel Diebo, Virginie Lafage, Shay Bess, Eric O Klineberg
STUDY DESIGN: Retrospective analysis of three prospectively collected databases. OBJECTIVE: compare peri-operative outcomes in Adult Spinal Deformity (ASD) surgeries in a surgeon-run (SR-ASD) and two national databases: the Nationwide Inpatient Sample (NIS) and the National Surgical Quality Improvement Program (NSQIP). SUMMARY OF BACKGROUND DATA: has been learned on the treatment of ASD in the last decade with prospective multicenter collaborative research focusing on this specific condition...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27922533/a-propensity-score-based-fine-stratification-approach-for-confounding-adjustment-when-exposure-is-infrequent
#14
Rishi J Desai, Kenneth J Rothman, Brian T Bateman, Sonia Hernandez-Diaz, Krista F Huybrechts
BACKGROUND: When exposure is infrequent, propensity score matching results in reduced precision because it discards a large proportion of unexposed patients. To our knowledge, the relative performance of propensity score stratification in these circumstances has not been examined. METHODS: Using an empirical example of the association of first-trimester statin exposure (prevalence=0.04%) with risk of congenital malformations and 1,000 simulated cohorts (n=20,000) with eight combinations of exposure prevalence (0...
November 29, 2016: Epidemiology
https://www.readbyqxmd.com/read/27922462/fostering-evidence-based-quality-improvement-for-patient-centered-medical-homes-initiating-local-quality-councils-to-transform-primary-care
#15
Susan E Stockdale, Jessica Zuchowski, Lisa V Rubenstein, Negar Sapir, Elizabeth M Yano, Lisa Altman, Jacqueline J Fickel, Skye McDougall, Timothy Dresselhaus, Alison B Hamilton
BACKGROUND: Although the patient-centered medical home endorses quality improvement principles, methods for supporting ongoing, systematic primary care quality improvement have not been evaluated. We introduced primary care quality councils at six Veterans Health Administration sites as an organizational intervention with three key design elements: (a) fostering interdisciplinary quality improvement leadership, (b) establishing a structured quality improvement process, and (c) facilitating organizationally aligned frontline quality improvement innovation...
December 3, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27922132/wideband-helicity-dependent-spoof-surface-plasmon-polaritons-coupling-metasurface-based-on-dispersion-design
#16
Guoxiang Dong, Hongyu Shi, Yuchen He, Anxue Zhang, Xiaoyong Wei, Yongyong Zhuang, Bai Du, Song Xia, Zhuo Xu
The surface plasmon polaritons (SPPs) have many potential application due to their local field enhancement and sub-wavelength characteristics. Recently, the gradient metasurface is introduced to couple the spoof SPPs in microwave frequency band. One of the most important issue which should be solved is the narrowband of spoof SPPs coupling on the gradient metasurface. Here, the metasurface is proposed to achieve the wideband helicity dependent directional spoof SPPs coupling for circular polarized light. Our research show that the coupling frequency of spoof SPPs on the gradient metasurface is determined by the dispersion of the metasurface, so the coupling frequency can be controlled by dispersion design...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922089/elderly-patients-have-an-altered-gut-brain-axis-regardless-of-the-presence-of-cirrhosis
#17
Jasmohan S Bajaj, Vishwadeep Ahluwalia, Joel L Steinberg, Sarah Hobgood, Peter A Boling, Michael Godschalk, Saima Habib, Melanie B White, Andrew Fagan, Edith A Gavis, Dinesh Ganapathy, Phillip B Hylemon, Karen E Stewart, Raffi Keradman, Eric J Liu, Jessica Wang, Patrick M Gillevet, Masoumeh Sikaroodi, F Gerard Moeller, James B Wade
Cognitive difficulties manifested by the growing elderly population with cirrhosis could be amnestic (memory-related) or non-amnestic (memory-unrelated). The underlying neuro-biological and gut-brain changes are unclear in this population. We aimed to define gut-brain axis alterations in elderly cirrhotics compared to non-cirrhotic individuals based on presence of cirrhosis and on neuropsychological performance. Age-matched outpatients with/without cirrhosis underwent cognitive testing (amnestic/non-amnestic domains), quality of life (HRQOL), multi-modal MRI (fMRI go/no-go task, volumetry and MR spectroscopy), blood (inflammatory cytokines) and stool collection (for microbiota)...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922086/photoelectrochemical-detection-of-alpha-fetoprotein-based-on-zno-inverse-opals-structure-electrodes-modified-by-ag2s-nanoparticles
#18
Yandong Jiang, Dali Liu, Yudan Yang, Ru Xu, Tianxiang Zhang, Kuang Sheng, Hongwei Song
In this work, a new photoelectrochemical biosensor based on Ag2S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag2S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag2S expanded the scope of light absorption to long wavelength, which can make full use of the light energy...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922058/edge-enhancement-improves-disruptive-camouflage-by-emphasising-false-edges-and-creating-pictorial-relief
#19
John Egan, Rebecca J Sharman, Kenneth C Scott-Brown, Paul George Lovell
Disruptive colouration is a visual camouflage composed of false edges and boundaries. Many disruptively camouflaged animals feature enhanced edges; light patches are surrounded by a lighter outline and/or a dark patches are surrounded by a darker outline. This camouflage is particularly common in amphibians, reptiles and lepidopterans. We explored the role that this pattern has in creating effective camouflage. In a visual search task utilising an ultra-large display area mimicking search tasks that might be found in nature, edge enhanced disruptive camouflage increases crypsis, even on substrates that do not provide an obvious visual match...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922024/improvements-in-the-long-term-outcome-of-crohn-s-disease-over-the-past-two-decades-and-the-relation-to-changes-in-medical-management-results-from-the-population-based-ibdsl-cohort
#20
Steven F G Jeuring, Tim R A van den Heuvel, Limmie Y L Liu, Maurice P Zeegers, Wim H Hameeteman, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Ad A M Masclee, Daisy M A E Jonkers, Marieke J Pierik
OBJECTIVES: Medical treatment options and strategies for Crohn's disease (CD) have changed over the past decades. To assess its impact, we studied the evolution of the long-term disease outcome in the Dutch Inflammatory Bowel Disease South Limburg (IBDSL) cohort. METHODS: In total, 1,162 CD patients were included. Three eras were distinguished: 1991-1998 (n=316), 1999-2005 (n=387), and 2006-2011 (n=459), and patients were followed until 2014. Medication exposure and the rates of hospitalization, surgery, and phenotype progression were estimated using Kaplan-Meier survival analyses and compared between eras by multivariable Cox regression models...
December 6, 2016: American Journal of Gastroenterology
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