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Cholesterol controversy

Željko Reiner
Although elevated serum low-density lipoprotein-cholesterol (LDL-C) is without any doubts accepted as an important risk factor for cardiovascular disease (CVD), the role of elevated triglycerides (TGs)-rich lipoproteins as an independent risk factor has until recently been quite controversial. Recent data strongly suggest that elevated TG-rich lipoproteins are an independent risk factor for CVD and that therapeutic targeting of them could possibly provide further benefit in reducing CVD morbidity, events and mortality, apart from LDL-C lowering...
December 2018: Korean Circulation Journal
Xingxing Song, Weijing Wang, Zongyao Li, Dongfeng Zhang
BACKGROUND: As an essential trace element, copper has been considered to play an important role in lipid metabolism. However, the associations of serum copper with lipid concentration and dyslipidemia are still controversial. METHODS: We used the 2011-2014 National Health and Nutrition Examination Survey to examine the relationship between serum copper and lipid concentration among participants aged 20 years and older. Multivariate linear regression was conducted to estimate the differences in the level of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol...
October 26, 2018: Annals of Nutrition & Metabolism
Edith Angellotti, David D'Alessio, Bess Dawson-Hughes, Yan Chu, Jason Nelson, Peter Hu, Robert M Cohen, Anastassios G Pittas
BACKGROUND & AIMS: Whether vitamin D affects lipid profile and cardiovascular disease (CVD) risk is controversial. We evaluated the effect of oral daily vitamin D supplementation on lipid profile and CVD risk in patients with well-controlled type 2 diabetes. METHODS: Secondary analysis in the vitamin D for established type 2 diabetes (DDM2) study, a double-blind, randomized, placebo-controlled clinical trial. 127 patients (mean age 60 years) with stable (HbA1c ≤ 7...
October 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Katsuya Sakimura, Tatsuya Maekawa, Shin-Ichi Kume, Takeshi Ohta
In patients with diabetes mellitus (DM), impairments of circadian rhythms, including the sleep-wake cycle, blood pressure, and plasma melatonin concentrations, are frequently observed. Animal models of DM are also reported to show aberrant circadian rhythms. However, the changes in the circadian rhythms of plasma soluble substances, including melatonin, in diabetic animals are controversial. In the present study, we investigated the circadian rhythms of spontaneous locomotor activity, metabolic parameters (plasma glucose, triglyceride, and total cholesterol), and plasma melatonin concentrations in Spontaneously Diabetic Torii (SDT) fatty rats, a novel animal model of type 2 DM...
2018: International Journal of Endocrinology
Cong Ai, Shanshan Zhang, Qiao He, Jingpu Shi
BACKGROUND: Although there were many studies reporting the combination therapy of Ezetimibe and Atorvastatin's efficacy and Atorvastatin monotherapy's, the conclusions were controversial. Therefore, a systematic review and meta analysis of combination therapy and monotherapy were conducted. METHODS: PubMed, Cochrane Library and Embase were searched for studies of the combination therapy of Ezetimibe and Atorvastatin and Atorvastatin monotherapy published up to October 20, 2017...
October 17, 2018: Lipids in Health and Disease
Irene Marginedas-Freixa, Cora L Alvarez, Martina Moras, Claude Hattab, Guillaume Bouyer, Arnaud Chene, Sophie D Lefevre, Caroline Le Van Kim, Frederic Bihel, Pablo J Schwarzbaum, Mariano A Ostuni
Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic reticulum. The design of specific tools is necessary to determine the molecular associations and functions of TSPO, which remain controversial nowadays. We recently demonstrated that TSPO2 is involved in a supramolecular complex of the erythrocyte membrane, where micromolar doses of the classical TSPO ligands induce ATP release and zinc protoporphyrin (ZnPPIX) transport...
October 10, 2018: International Journal of Molecular Sciences
Omar Yaxmehen Bello-Chavolla, Anuar Kuri-García, Monserratte Ríos-Ríos, Arsenio Vargas-Vázquez, Jorge Eduardo Cortés-Arroyo, Gabriela Tapia-González, Ivette Cruz-Bautista, Carlos Alberto Aguilar-Salinas
Familial combined hyperlipidemia (FCHL) is the most prevalent primary dyslipidemia; however, it frequently remains undiagnosed and its precise definition is a subject of controversy. FCHL is characterized by fluctuations in serum lipid concentrations and may present as mixed hyperlipidemia, isolated hypercholesterolemia, hypertriglyceridemia, or as a normal serum lipid profile in combination with abnormally elevated levels of apolipoprotein B. FCHL is an oligogenic primary lipid disorder, which can occur due to the interaction of several contributing variants and mutations along with environmental triggers...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Hyun Cheol Jeong, Fahad K Bashraheel, Seok-Soo Byun, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Tae-Hwan Kim, Yong-June Kim, Sung-Hoo Hong
AIM: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. METHODS: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163...
October 10, 2018: Asia-Pacific Journal of Clinical Oncology
Rodrigo R Da Conceição, Gustavo W Fernandes, Tatiana L Fonseca, Barbara M L C Bocco, Antonio C Bianco
BACKGROUND: Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application is chronic administration along with levothyroxine in the treatment of hypothyroidism. Long-term treatment with LT3 is complicated by its unique pharmacokinetics that result in a substantial triiodothyronine (T3) peak in the blood three to four hours after oral dosing. This is a significant problem, given that T3 levels in the blood are normally stable, varying by <10% throughout the day...
November 2018: Thyroid: Official Journal of the American Thyroid Association
Xun Sun, Ye Xiao, Pei-Mei Li, Xiu-Yun Ma, Xiao-Jie Sun, Wen-Shan Lv, Yi-Li Wu, Peng Liu, Yan-Gang Wang
BACKGROUND: The association of serum high-density lipoprotein cholesterol (HDL-C) with microalbuminuria in type 2 diabetes mellitus (T2DM) remains controversial. Therefore, a cross-sectional study was conducted on patients with T2DM to investigate the relationship of HDL-C with microalbuminuria. METHODS: A total of 524 participants with T2DM were recruited in this cross-sectional study. The patients were divided into four groups according to serum HDL-C quartile...
October 5, 2018: Lipids in Health and Disease
Amir Hadi, Makan Pourmasoumi, Ameneh Najafgholizadeh, Marziyeh Kafeshani, Amirhossein Sahebkar
Despite a history of purslane usage as a herbal treatment for dyslipidemia and hyperglycemia management, existing evidence from clinical trials is controversial. The aim for the current study was to evaluate the efficacy of purslane supplementation on lipid parameters and glycemic status in adult populations. A systematic review was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 15, 2018, searching for randomized controlled trials that assessed the impact of purslane on fasting blood glucose (FBG), triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)...
October 3, 2018: Phytotherapy Research: PTR
Ryo Ohtani, Shinsuke Nirengi, Michikazu Nakamura, Nagako Murase, Makoto Sainouchi, Yasuhiro Kuwata, Masaki Takata, Yuuichi Masuda, Kazuhiko Kotani, Naoki Sakane
BACKGROUND: High-density lipoprotein (HDL) containing apolipoprotein A-I is associated with the pathogenesis of Alzheimer's disease (AD). HDL particle size is modified in the presence of pathological conditions, while the significance of the HDL particle size remains controversial. OBJECTIVE: The aim of this study was to investigate the HDL lipoprotein subclasses in mild cognitive impairment (MCI) and AD. METHODS: This cross-sectional study included 20 AD patients, 17 MCI patients, and 17 age-matched controls without cognitive impairment, selected from the database of the Study of Outcome and aPolipoproteins in Dementia (STOP-Dementia) registry...
2018: Journal of Alzheimer's Disease: JAD
Yusuf Nazir, Syed Ammar Hussain, Aidil Abdul Hamid, Yuanda Song
The potential health benefits of probiotics have long been elucidated since Metchnikoff and his coworkers postulated the association of probiotic consumption on human's health and longevity. Since then, many scientific findings and research have further established the correlation of probiotic and gut-associated diseases such as irritable bowel disease and chronic and antibiotic-associated diarrhea. However, the beneficial impact of probiotic is not limited to the gut-associated diseases alone, but also in different acute and chronic infectious diseases...
2018: BioMed Research International
Xilong Deng, Jie Ma, Meiting Song, Ye Jin, Cheng Ji, Weihong Ge, Changrun Guo
PURPOSE: Fatalities due to heart and cerebrovascular diseases caused by uncontrolled hyperlipidaemia increase every year; on the other hand, lipid-lowering drugs are known to cause side effects. The gut microbiota has been thoroughly investigated by researchers and consumers, because they have unique functional properties and littler side effects. However, the effects of the gut microbiota remain controversial. We conducted a meta-analysis to assess the effects of products designed to modulate the gut microbiota on various hyperlipidaemias...
September 20, 2018: European Journal of Nutrition
Junling Fu, Lanwen Han, Yanglu Zhao, Ge Li, Yingna Zhu, Yu Li, Ming Li, Shan Gao, Steven M Willi
BACKGROUND AND AIMS: The relationship between vitamin D deficiency and metabolic syndrome (MS) remains controversial with relatively sparse data among youth. Therefore, we attempted to explicate the association of 25-hydroxyvitamin D [25(OH)D] levels with MS in Chinese adolescents and young adults. METHODS: A cohort of 559 subjects at elevated risk of MS were recruited at 14-28 years of age as a follow-up to the Beijing Child and Adolescent Metabolic Syndrome Study...
September 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Yujie Wu, Xuenong Xing, Shandong Ye, Chao Chen, Jumei Wang
OBJECTIVE: Osteoporosis is a systemic skeletal disorder characterizedby reduced bone mass, deteriorated bone structure. Various studies have tried to evaluate the association between lipid level and osteoporosis, but the results were proved to be controversial. The objectives of this study are to assess the correlation between BMD and serum lipid levels, to determine independent variables associated with osteoporosis and osteopenia in men and postmenopausal women with type 2 diabetes (T2D)...
September 20, 2018: Experimental and Clinical Endocrinology & Diabetes
Andreja Dimic, Miroslav Markovic, Dragan Vasic, Marko Dragas, Petar Zlatanovic, Aleksandar Mitrovic, Lazar Davidovic
BACKGROUND: Diabetes mellitus increases the risk of ischaemic stroke in the general population but its impact on early outcome after the carotid endarterectomy (CEA) is controversial with conflicting results. PATIENTS AND METHODS: This prospective study includes 902 consecutive CEAs. Patients were divided into non-diabetic and diabetic groups and subsequently analysed. Early outcomes in terms of 30-day stroke and death rates were then analysed and compared. RESULTS: There were 606 non-diabetic patients...
September 7, 2018: VASA. Zeitschrift Für Gefässkrankheiten
Kevin C Maki, Fulya Eren, Martha E Cassens, Mary R Dicklin, Michael H Davidson
The 2015 Dietary Guidelines for Americans recommend limiting the intake of saturated fatty acids (SFAs) to <10% of energy/d and replacing dietary SFAs with unsaturated fatty acids. A Presidential Advisory from the American Heart Association recently released its evaluation of the relation between dietary fats and cardiovascular disease (CVD), and also recommended a shift from SFAs to unsaturated fatty acids, especially polyunsaturated fatty acids (PUFAs), in conjunction with a healthy dietary pattern. However, the suggestion to increase the intake of PUFAs in general, and omega-6 (n-6) PUFAs in particular, continues to be controversial...
September 4, 2018: Advances in Nutrition
Xinyan Bi, Yi Ting Loo, Christiani Jeyakumar Henry
OBJECTIVES: Regional fat accumulation may play an important role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular diseases, yet the results are controversial. The aim of this study was to determine the relationship between regional fat accumulation and MetS as well as the underlying mechanism in Chinese adults. METHODS: We conducted a cross-sectional study of 428 Chinese adults (166 men and 262 women). Android and gynoid fat percentage (AFP and GFP) were measured by dual energy x-ray absorptiometry...
June 19, 2018: Nutrition
Alison J Mbekeani, Will A Stanley, Vishal C Kalel, Noa Dahan, Einat Zalckvar, Lilach Sheiner, Wolfgang Schliebs, Ralf Erdmann, Ehmke Pohl, Paul W Denny
Peroxisomes are central to eukaryotic metabolism, including the oxidation of fatty acids-which subsequently provide an important source of metabolic energy-and in the biosynthesis of cholesterol and plasmalogens. However, the presence and nature of peroxisomes in the parasitic apicomplexan protozoa remains controversial. A survey of the available genomes revealed that genes encoding peroxisome biogenesis factors, so-called peroxins (Pex), are only present in a subset of these parasites, the coccidia. The basic principle of peroxisomal protein import is evolutionarily conserved, proteins harbouring a peroxisomal-targeting signal 1 (PTS1) interact in the cytosol with the shuttling receptor Pex5 and are then imported into the peroxisome via the membrane-bound protein complex formed by Pex13 and Pex14...
August 29, 2018: Genes
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