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https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#1
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27890613/activation-of-ppar%C3%AE-does-not-contribute-to-macrophage-abca1-expression-and-abca1-mediated-cholesterol-efflux-to-apoai
#2
Meixiu Jiang, Xiaoju Li
Activation of macrophage ABCA1/G1 expression and cholesterol efflux is believed one of the mechanisms by which PPARγ inhibits atherosclerosis. PPARγ can also activate CD36 expression, a receptor for oxLDL, which may supply LXR ligands to activate LXR-ABCA1/G1 pathways. However, the controversial effects of PPARγ on ABCA1 expression have been reported. In this study, we used peritoneal macrophages isolated from wild type and CD36 deficient (CD36(-/-)) mice to clarify if PPARγ ligands can influence ABCA1 expression by CD36 function...
November 24, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27879044/clustering-according-to-urolithin-metabotype-explains-the-interindividual-variability-in-the-improvement-of-cardiovascular-risk-biomarkers-in-overweight-obese-individuals-consuming-pomegranate-a-randomised-clinical-trial
#3
Antonio González-Sarrías, Rocío García-Villalba, María Romo-Vaquero, Cesarettin Alasalvar, Asim Örem, Pilar Zafrilla, Francisco A Tomás-Barberán, María V Selma, Juan Carlos Espín
SCOPE: The pomegranate lipid-lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. OBJECTIVE: We aimed at investigating whether the microbial-derived ellagitannin-metabolizing phenotypes, i.e. urolithin metabotypes A, (UM-A), B (UM-B) and 0 (UM-0), influence the effects of pomegranate extract (PE) consumption on eighteen cardiovascular risk biomarkers in healthy overweight-obese individuals...
November 23, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27832688/changes-in-body-mass-index-and-lipid-profile-in-psoriatic-patients-after-treatment-with-standard-protocol-of-infliximab
#4
Amir Houshang Ehsani, Hossein Mortazavi, Kamran Balighi, Mahboubeh Sadat Hosseini, Arghavan Azizpour, Seyyedeh Pardis Hejazi, Azadeh Goodarzi, Seyyedeh Bahareh Darvari
Psoriasis is a chronic and inflammatory dermatologic disease. Psoriasis may predispose to cardiovascular disease and diabetes. However, the role of tumor necrosis factor (TNF) inhibitor in mediating this risk is controversial. Regarding frequent use of infliximab in psoriasis, and the hypothesis that anti TNF-α treatment may increase Body Mass Index (BMI) and alter lipid profile in these patients, the aim of this study was to assess changes in BMI and Lipid Profile and level of leptin in Psoriatic Patients under Treatment of Standard Protocol of Infliximab in a 24 week period...
September 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27832037/effects-of-helicobacter-pylori-eradication-on-insulin-resistance-and-metabolic-parameters-a-systematic-review-and-meta-analysis
#5
Sikarin Upala, Anawin Sanguankeo, Sheikh A Saleem, Veeravich Jaruvongvanich
INTRODUCTION: Previous studies have shown a close relationship between Helicobacter pylori (H. pylori), insulin resistance, and altered metabolic parameters. However, the effects of H. pylori eradication on these conditions remain controversial. We carried out a systematic review and meta-analysis to evaluate the effects of H. pylori eradication on insulin resistance and metabolic parameters. METHODS: We searched CENTRAL, MEDLINE, and EMBASE databases from their inception to July 2016...
November 9, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27826954/critical-and-diverse-in-vivo-roles-of-apoptosis-signal-regulating-kinase-1-in-animal-models-of-atherosclerosis-and-cholestatic-liver-injury
#6
REVIEW
Sohsuke Yamada, Hirotsugu Noguchi, Akihide Tanimoto
Apoptosis plays pivotal in vivo roles in not only vital processes, such as cell turnover and embryonic development, but also various inflammatory disorders. However, the role of apoptosis by vascular and hepatic cells in the respective progression of atherosclerosis and liver injury remains controversial. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase family member that is activated through distinct mechanisms in response to various cytotoxic stressors. ASK1, ubiquitously expressed, is situated in an important upstream position for many signal transduction pathways, which subsequently induce inflammation and/or apoptosis...
November 9, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27819144/effects-of-sodium-glucose-co-transporter-2-inhibitors-on-metabolism-unanswered-questions-and-controversies
#7
Vasilios Tsimihodimos, Theodosios D Filippatos, Moses S Elisaf
Sodium-glucose co-transporter 2 (SGLT2) inhibitors inhibit glucose re-absorption in the proximal renal tubules. These drugs also affect many anthropometric and metabolic parameters with various mechanisms of action. Areas covered: We present the available evidence regarding these effects. SGLT2 inhibitors can decrease body weight mainly due to a reduction of total fat mass. SGLT2 inhibitors can decrease blood pressure levels and serum uric acid levels and may also reduce the degree of diabetes-related albuminuria...
November 17, 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27801864/tocotrienol-affects-oxidative-stress-cholesterol-homeostasis-and-the-amyloidogenic-pathway-in-neuroblastoma-cells-consequences-for-alzheimer-s-disease
#8
Marcus O W Grimm, Liesa Regner, Janine Mett, Christoph P Stahlmann, Pascal Schorr, Christopher Nelke, Olga Streidenberger, Hannah Stoetzel, Jakob Winkler, Shatha R Zaidan, Andrea Thiel, Kristina Endres, Heike S Grimm, Dietrich A Volmer, Tobias Hartmann
One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with a reduced risk of AD due to its antioxidative properties. However, epidemiological studies and nutritional approaches of vitamin E treatment are controversial. Here, we investigate the effect of α-tocotrienol, which belongs to the group of vitamin E, on AD-relevant processes in neuronal cell lines...
October 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27792695/-gender-differences-in-lipocalin-2-plasmatic-levels-are-correlated-with-age-and-the-triglyceride-high-density-lipoprotein-ratio-in-healthy-individuals
#9
Elsa De la Chesnaye, Leticia Manuel-Apolinar, Norma Oviedo-de Anda, María Cristina Revilla-Monsalve, Sergio Islas-Andrade
INTRODUCTION: The increment of lipocalin 2, also called neutrophil gelatinase-associated lipocalin, plasmatic levels is associated with cardiometabolic and nefrologic alterations. Nonetheless, there is much controversy about lipocalin 2 plasmatic concentrations among healthy individuals. AIM: The aim of this study was to quantify lipocalin 2 in plasma of healthy men and women and to assess a possible correlation with cardiometabolic risk factors. METHODS: Fifty-three subjects (24 men and 29 women) were included...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27771738/serum-dehydroepiandrosterone-levels-are-associated-with-lower-risk-of-type-2-diabetes-the-rotterdam-study
#10
Adela Brahimaj, Taulant Muka, Maryam Kavousi, Joop S E Laven, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. METHODS: We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27749232/prevalence-of-vitamin-d-deficiency-in-rheumatoid-arthritis-and-association-with-disease-activity-and-cardiovascular-risk-factors-data-from-the-comedra-study
#11
Stella Cecchetti, Zuzana Tatar, Pilar Galan, Bruno Pereira, Céline Lambert, Gael Mouterde, Angela Sutton, Martin Soubrier, Maxime Dougados
OBJECTIVES: The relationship between vitamin D and rheumatoid arthritis (RA) activity remains controversial. RA is a cardiovascular risk factor. A low level of vitamin D may increase blood pressure (BP) and decrease HDL-cholesterol. OBJECTIVES: We aimed to determine the prevalence of vitamin D deficiency in RA patients compared to controls, and also to investigate the relationship between vitamin D and RA activity, and between vitamin D and cardiovascular risk factors...
September 30, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27747489/current-consensus-and-controversies-in-guidelines-for-lipid-and-hypertension-management-in-diabetes
#12
Om P Ganda, Joanna Mitri
Despite major advances, many patients with diabetes are currently achieving suboptimal control of lipids and blood pressure. The new cholesterol guidelines by the ACC/AHA have reignited the emphasis on more intensive treatment with statins in the population at high risk of CVD, including those with diabetes. While these guidelines do not include specific lipid goals, several other guidelines have retained previously defined risk-based LDL-C and non-HDL-C goals. More recent data indicate potential benefits in CVD outcomes with non-statin therapy added to statin therapy...
November 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27730076/high-atherogenic-index-of-plasma-in-subclinical-hypothyroidism-implications-in-assessment-of-cardiovascular-disease-risk
#13
Stephen R James, Lopamudra Ray, Kandasamy Ravichandran, Sunil Kumar Nanda
BACKGROUND: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. AIM: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH. MATERIALS AND METHODS: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27717019/lipid-profile-in-patients-with-androgenetic-alopecia-a-meta-analysis
#14
REVIEW
M W Kim, I S Shin, H S Yoon, S Cho, H S Park
BACKGROUND: Many studies have reported that androgenetic alopecia (AGA) might be a risk factor for cardiovascular disorders, and the association of AGA with dyslipidaemia has been studied. However, the results were controversial and previous meta-analyses had several critical limitations. OBJECTIVE: We performed a meta-analysis to clarify whether AGA patients have abnormal lipid profiles. METHODS: A literature search was performed using the MEDLINE, EMBASE, The Cochrane Library and KOREA MED databases...
October 7, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27716557/circulating-level-of-pigment-epithelium-derived-factor-is-associated-with-vascular-function-and-structure-a-cross-sectional-study
#15
Masato Kajikawa, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Yoshiki Aibara, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takanori Matsui, Sho-Ichi Yamagishi, Yukihito Higashi
BACKGROUND: Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors. It is thought that PEDF plays a protective role against atherosclerosis. Clinical studies have shown that serum levels of PEDF are increased in subjects with cardiovascular risk factors. The role of PEDF in cardiovascular disease is still controversial. The purpose of this study was to evaluate the associations between serum levels of PEDF and vascular function and structure...
October 3, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27712954/2016-canadian-cardiovascular-society-guidelines-for-the-management-of-dyslipidemia-for-the-prevention-of-cardiovascular-disease-in-the-adult
#16
Todd J Anderson, Jean Grégoire, Glen J Pearson, Arden R Barry, Patrick Couture, Martin Dawes, Gordon A Francis, Jacques Genest, Steven Grover, Milan Gupta, Robert A Hegele, David C Lau, Lawrence A Leiter, Eva Lonn, G B John Mancini, Ruth McPherson, Daniel Ngui, Paul Poirier, John L Sievenpiper, James A Stone, George Thanassoulis, Richard Ward
Since the publication of the 2012 guidelines new literature has emerged to inform decision-making. The 2016 guidelines primary panel selected a number of clinically relevant questions and has produced updated recommendations, on the basis of important new findings. In subjects with clinical atherosclerosis, abdominal aortic aneurysm, most subjects with diabetes or chronic kidney disease, and those with low-density lipoprotein cholesterol ≥ 5 mmol/L, statin therapy is recommended. For all others, there is an emphasis on risk assessment linked to lipid determination to optimize decision-making...
July 25, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27704320/association-between-serum-%C3%AE-glutamyltransferase-and-chronic-kidney-disease-in-urban-han-chinese-a-prospective-cohort-study
#17
Zhen-Wei Shen, Jie Xing, Qing-Lian Wang, Ali Faheem, Xiang Ji, Jie Li, Wei-Wei Bian, Zheng Jiang, Xiu-Jun Li, Fu-Zhong Xue, Jing Liu
PURPOSE: Limited numbers of literatures have focused on the association between γ-glutamyltransferase (GGT) and chronic kidney disease (CKD), and their results were controversial. Therefore, in this study, we set up a large-scale cohort of Chinese population to discover and verify the association between serum GGT and CKD. METHODS: Our cohort study was based on 21,818 patients who visited Health Management Center of Shandong Provincial Hospital, China, to receive routine health check-up during the period of 2005-2010, and we used multivariate Cox regression model to clarify whether elevated serum GGT increased the risk of CKD or not...
October 4, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27699011/effect-of-l-thyroxine-treatment-versus-a-placebo-on-serum-lipid-levels-in-patients-with-sub-clinical-hypothyroidism
#18
Xue Li, Zhaowei Meng, Qiang Jia, Xiaojun Ren
Sub-clinical hypothyroidism is a common disease and whether L-thyroxine replacement treatment improves serum lipid levels in affected patients remains controversial. Thus, the aim of the present meta-analysis was to assess the effect of L-thyroxine therapy on serum lipid levels in sub-clinical hyperthyroidism. Relevant randomized controlled trials (RCTs) containing continuous data, published until July 2015 were retrieved from the Cochrane Library, PubMed, Medline, Google Scholar and Embase databases and subjected to meta-analysis using Review Manager software version 5...
October 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27696759/high-cholesterol-dietary-intake-during-pregnancy-is-associated-with-large-for-gestational-age-in-a-sample-of-low-income-women-of-rio-de-janeiro-brazil
#19
Maria Beatriz Trindade de Castro, Dayana Rodrigues Farias, Jaqueline Lepsch, Roberta Hack Mendes, Aline Alves Ferreira, Gilberto Kac
The association between the quality of maternal dietary fat intake during pregnancy and the infant's birthweight (BW) remains controversial. Our goal was to investigate the association between maternal dietary fat intake during pregnancy and the rate of large for gestational age (LGA) newborns. This study employed a cross-sectional analysis of 297 pairs of mothers/children attending a public maternity at Rio de Janeiro, Brazil. BW for gestational age according to the Intergrowth 21st was defined as follows: adequate for gestational age (AGA ≤ 90th percentile) and LGA (>90th percentile)...
October 3, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27694812/a-plasma-membrane-microdomain-compartmentalizes-ephrin-generated-camp-signals-to-prune-developing-retinal-axon-arbors
#20
Stefania Averaimo, Ahlem Assali, Oriol Ros, Sandrine Couvet, Yvrick Zagar, Ioana Genescu, Alexandra Rebsam, Xavier Nicol
The development of neuronal circuits is controlled by guidance molecules that are hypothesized to interact with the cholesterol-enriched domains of the plasma membrane termed lipid rafts. Whether such domains enable local intracellular signalling at the submicrometre scale in developing neurons and are required for shaping the nervous system connectivity in vivo remains controversial. Here, we report a role for lipid rafts in generating domains of local cAMP signalling in axonal growth cones downstream of ephrin-A repulsive guidance cues...
October 3, 2016: Nature Communications
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