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paraoxonase 1

G Czechowska, K Celinski, A Korolczuk, G Wojcicka, J Dudka, A Bojarska, A Madro, T Brzozowski
It has been reported previously that the density of angiotensin II receptors is increased in the rat liver in experimentally-induced fibrosis. We hypothesized that pharmacological blockade of angiotensin receptors may produce beneficial effects in models of liver fibrosis. In this study, we used the widely used thioacetamide (TAA)-induced model of liver fibrosis (300 mg/L TAA ad libitum for 12 weeks). Rats received daily injections (i.p), lasting 4 weeks of the angiotensin II type 1 receptor antagonists, losartan 30 mg/kg (TAA + L) or telmisartan 10 mg/kg (TAA + T) and were compared to rat that received TAA alone...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Elizabete de Jesus Inês, Mônica Lopes Sampaio Silva, Joelma Nascimento de Souza, Alana Alcântara Galvão, Márcia Cristina Aquino Teixeira, Neci Matos Soares
The objective of this study was to investigate paraoxonase-1 (PON1) activity, cortisol levels, and the lipid profile in the sera of alcoholic and non-alcoholic Strongyloides stercoralis-infected and uninfected individuals in a sample of 276 individuals attended at the National Health System in Salvador, Bahia, Brazil. The activity of PON1 was measured by the Beltowski method, serum lipids, and cortisol levels using commercial kits. PON1 activity was low in both alcoholic and non-alcoholic individuals infected with S...
October 19, 2016: Acta Tropica
Zahoor Qadir Samra, Sadaf Shabir, Zainab Rahmat, Mariam Zaman, Aqsa Nazir, Nadia Dar, Muhammad Amin Athar
No abstract text is available yet for this article.
October 18, 2016: Applied Biochemistry and Biotechnology
Saleh Ayashi, Ahmad Reza Assareh, Mohammad Taha Jalali, Samaneh Olapour, Hamid Yaghooti
OBJECTIVE: Carvedilol is a nonselective third generation β-blocker that does not display the negative effects of traditional β-blockers. Regarding the antioxidant, anti-inflammatory and distinct metabolic properties of carvedilol which are similar to that of high-density lipoprotein (HDL) and paraoxonase 1 (PON1), the present study intends to investigate the effects of carvedilol treatment on malondialdehyde (MDA) and soluble lectin-like ox-low-density lipoprotein (LDL) receptor (sLOX-1) as markers of oxidative stress in association to lipid profiles, apolipoproteins (apo), and PON1 activity in hypertensive patients...
July 2016: Indian Journal of Pharmacology
Huseyin Besiroglu, Mustafa Kadihasanoglu, Emin Ozbek
No abstract text is available yet for this article.
October 17, 2016: Renal Failure
Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Sandra T Orta-García, G Domínguez-Cortinas, Jorge A Jiménez-Avalos, Iván N Pérez-Maldonado
AIM: This study aimed to evaluate the genetic effects of PON1 Q192R polymorphism on serum FABP4 levels in Mexican women. METHODS: PON1 Q192R polymorphism was genotyped using a TaqMan allelic discrimination assay and serum FABP4 concentration was measured using an enzyme-linked immunosorbent assay. RESULTS: The distribution of genotype frequencies in the assessed women (PON1 Q192R polymorphism) was QQ = 20%, QR = 48%, and RR = 32%...
October 6, 2016: Annals of Human Biology
Lai Peng, Stephanie Piekos, Grace L Guo, Xiao-Bo Zhong
The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver. However, the role of FXR in regulating ontogeny of phase-I drug metabolizing genes is not clear. Hence, we applied RNA-sequencing to quantify the developmental expression of phase-I genes in both Fxr-null and control (C57BL/6) mouse livers during development. Liver samples of male C57BL/6 and Fxr-null mice at 6 different ages from prenatal to adult were used...
September 2016: Acta Pharmaceutica Sinica. B
Kannadasan AnandBabu, S R Bharathidevi, Sarangapani Sripriya, Parveen Sen, Vadivelu Jaya Prakash, Appukuttan Bindu, Natarajan Viswanathan, Narayanasamy Angayarkanni
Age-related Macular Degeneration (AMD) is a multifactorial disease causing visual impairment in old age. Oxidative stress is one of the main contributors for the disease progression. Paraoxonase (PON), a HDL-resident antioxidant enzyme which removes oxidized low density lipoprotein (oxLDL), which is not studied much in AMD. This study assesses the PON activities in relation to the lipid status and genetic variants in AMD patients. In this prospective case-control study, a total of 48 AMD patients and 30 unrelated healthy controls were recruited...
September 28, 2016: Experimental Eye Research
A Jamroz-Wiśniewska, J Bełtowski, H Bartosik-Psujek, G Wójcicka, K Rejdak
BACKGROUND: Homocysteine thiolactone (HTL) is a cyclic thioester of homocysteine (Hcy) contributing to the toxicity of this amino acid. HTL spontaneously reacts with protein lysine residues leading to altered properties of target proteins and induction of immune response. HTL is hydrolyzed to Hcy by plasma enzyme, paraoxonase 1 (PON1). Although both Hcy and PON1 may be involved in the pathogenesis of multiple sclerosis (MS), protein modification by HTL in this disease has not been studied so far...
October 14, 2016: International Journal of Neuroscience
Didem Turgut Cosan, E Colak, F Saydam, H U Yazıcı, I Degirmenci, A Birdane, E Colak, H V Gunes
Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as an antioxidant. Polymorphism in this gene has been investigated for many metabolic diseases, but it is not thought to be a genetic risk factor for essential hypertension. The aim of this study was to determine whether there was an association between PON1 gene polymorphisms and concentration with essential hypertension...
2016: Clinical and Experimental Hypertension: CHE
Yanyong Xu, Hongmei Liu, Mengting Liu, Feifei Li, Liangchen Liu, Fen Du, Daping Fan, Hong Yu
Apolipoprotein E (apoE) is well known as an antiatherogenic protein via regulating lipid metabolism and inflammation. We previously reported that a human apoE mimetic peptide, EpK, reduced atherosclerosis in apoE null (apoE(-/-)) mice through reducing inflammation without affecting plasma lipid levels. Here, we construct another human apoE mimetic peptide, named hEp, and investigate whether expression of hEp can reduce atherosclerotic lesion development in aged female apoE(-/-) mice with pre-existing lesions...
2016: American Journal of Translational Research
Renata Rebeca Pereira, Isabel Cristina Mallosto Emerich de Abreu, Joyce Ferreira da Costa Guerra, Nara Nunes Lage, Juliana Márcia Macedo Lopes, Maísa Silva, Wanderson Geraldo de Lima, Marcelo Eustáquio Silva, Maria Lucia Pedrosa
Açai (Euterpe oleracea Mart.), a fruit from the Amazon region, has emerged as a promising source of polyphenols. Açai consumption has been increasing owing to ascribed health benefits and antioxidant properties; however, its effects on hepatic injury are limited. In this study, we evaluated the antioxidant effect of filtered açai pulp on the expression of paraoxonase (PON) isoforms and PON1 activity in rats with nonalcoholic fatty liver disease (NAFLD). The rats were fed a standard AIN-93M (control) diet or a high-fat (HF) diet containing 25% soy oil and 1% cholesterol with or without açai pulp (2 g/day) for 6 weeks...
2016: Oxidative Medicine and Cellular Longevity
Osvaldo Fridman, Luis Gariglio, Stephanie Riviere, Rafael Porcile, Alicia Fuchs, Miguel Potenzoni
OBJECTIVES: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. METHODS: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR...
September 15, 2016: Archivos de Cardiología de México
Jordi Camps, Anna Hernández-Aguilera, Anabel García-Heredia, Noemí Cabré, Fedra Luciano-Mateo, Meritxell Arenas, Jorge Joven
Metformin is a biguanide used in the treatment of type 2 diabetes mellitus and obesity. The main mechanism of action is to decrease the intestinal glucose absorption and the hepatic glucose production. It does not influence insulin secretion. Metformin also increases the affinity of the insulin receptor, reduces high insulin levels and improves insulin resistance. Additionally, it promotes weight loss. Metformin is a pleiotropic compound but acts, largely, by activating 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK)...
September 15, 2016: Current Clinical Pharmacology
Abdolkarim Mahrooz
A growing interest exists in documenting the role of paraoxonase 1 (PON1) in different human diseases including, cardiovascular disease, obesity, diabetes mellitus, cancers, aging, and several neurological disorders. Three aspects of PON1 has attracted the attention of researchers: (1) hydrolyzing and detoxifying of toxic organophosphorous compounds such as nerve gases; (2) antioxidative activity in hydrolyzing oxidized phospholipids in high-density lipoprotein (HDL) and low-density lipoprotein (LDL); (3) interaction with various drugs...
September 15, 2016: Current Clinical Pharmacology
Elizabeth M S Schmidt, Asta Tvarijonaviciute, Silvia Martinez-Subiela, José J Cerón, Peter D Eckersall
BACKGROUND: Ancylostoma spp. is one of the most prevalent canine intestinal nematode infections which usually causes subclinical disease in adult dogs and has zoonotic implications. Therefore, the aim of this study was to explore and evaluate the possible pathophysiological changes that Ancylostoma spp. could produce in female dogs naturally infected but without clinical signs of disease, by screening a wide variety of biochemical markers for potential changes. Samples of feces and blood of 45 dogs were collected and fecal flotation and zinc sulphate centrifugal flotation were performed...
2016: BMC Veterinary Research
Tianzhu Zang, Ligi Paul Pottenplackel, Diane E Handy, Joseph Loscalzo, Shujia Dai, Richard C Deth, Zhaohui Sunny Zhou, Jisheng Ma
Elevated blood concentrations of homocysteine have been well established as a risk factor for cardiovascular diseases and neuropsychiatric diseases, yet the etiologic relationship of homocysteine to these disorders remains poorly understood. Protein N-homocysteinylation has been hypothesized as a contributing factor; however, it has not been examined globally owing to the lack of suitable detection methods. We recently developed a selective chemical method to label N-homocysteinylated proteins with a biotin-aldehyde tag followed by Western blotting analysis, which was further optimized in this study...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yan Zhang, Shijie Wang, Yongqin Li, Chunyan Zhang, Jiahong Xue, Xiaosan Wu, Congxia Wang
OBJECTIVE: To investigate the relationship of microRNA 616 (has-miR-616) single nucleotide polymorphisms (SNPs) and its target gene paraoxonase 1 (PON 1) with the prognosis of patients with premature coronary artery disease (pCAD). METHODS: 266 pCAD cases in the case group and 300 cases in the control group were collected. Using the polymorphism method of polymerase chain reaction and restriction fragment length, the has-miR-616 rs3735590 genotypes of target gene PON 1 were detected...
November 2016: International Journal of Clinical Pharmacology and Therapeutics
Gamaleldin I Harisa, Abdullah H Alomrani, Mohamed M Badran
This study aimed to investigate the effect of simvastatin (SV) loaded nanostructured lipid carriers (SV loaded NLCs) on atherogenic index (AI), erythrocytes membrane lipid and antioxidant/pro-oxidant status in hyperlipidemic rats. SV loaded NLCs were successfully prepared with desired nano-particles size, spherical shape, high encapsulation efficiency (EE %) and sustained SV release. The results of biological studies revealed that administration of SV loaded NLCs to rats increased SV bioavailability compared to SV suspension...
September 7, 2016: European Journal of Pharmaceutical Sciences
Min-Li Chen, Hua Zhao, Ning Liao, Zheng-Fu Xie
BACKGROUND The relationship between coronary heart disease (CHD) and the paraoxonase 2 (PON2) Ser311Cys polymorphism has received much attention. We conducted a meta-analysis on the results from published case-control studies examining this relation. MATERIAL AND METHODS A literature search was performed using PubMed and ISI Web of Knowledge databases until October 2015. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using Stata version 11.0 software. Data were pooled using the random-effects model...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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