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paraoxonase 1

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https://www.readbyqxmd.com/read/28719808/activated-neuro-oxidative-and-neuro-nitrosative-pathways-at-the-end-of-term-are-associated-with-inflammation-and-physio-somatic-and-depression-symptoms-while-predicting-outcome-characteristics-in-mother-and-baby
#1
Chutima Roomruangwong, Decio Sabbatini Barbosa, Andressa Keiko Matsumoto, André de Souza Nogueira, Buranee Kanchanatawan, Sunee Sirivichayakul, André F Carvalho, Sebastien Duleu, Michel Geffard, Estefania Gastaldello Moreira, Michael Maes
OBJECTIVES: To examine oxidative & nitrosative stress (O&NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. METHODS: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28691312/paraoxonase-1-pon1-activity-in-serum-follicular-fluid-and-seminal-plasma-of-sheep
#2
J Pradieé, F T de Campos, Jaa Rincon, L Collares, K Goularte, Pas Silveira, Lmc Pegoraro, A Schneider
This work aimed to describe the activity of paraoxonase 1 (PON1) in serum, follicular fluid and seminal plasma of sheep. Average serum PON1 activity was 286.8 ± 96.2 U/ml in females and 237.6 ± 18.9 U/ml in males. There was a positive correlation between PON1 activity in serum and follicular fluid in females, being twice higher in serum than in follicular fluid (148.8 ± 15.7 U/ml). PON1 activity in males' serum was 10-fold higher than in seminal plasma (21.18 ± 14.2 U/ml), and there was no correlation between PON1 activity in both compartments...
July 9, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28688923/paraoxonase-activities-in-human-follicular-fluid-role-in-follicular-maturation
#3
Susana Meijide, Irantzu Pérez-Ruiz, M Luisa Hernández, Rosaura Navarro, Marcos Ferrando, Zaloa Larreategui, José-Ignacio Ruiz-Sanz, M Begoña Ruiz-Larrea
The paraoxonases (PONs) are antioxidant enzymes associated with beneficial effects against several diseases and some exposures. Little is known, however, about the role of PONs in human reproduction. This work was conducted to investigate whether any association existed between the activities of the PON enzymes (1, 2, and 3) with the follicular size and fertility parameters in assisted reproduction. The study included 100 subfertile women (patients) and 55 proven fertile women (oocyte donors), all undergoing an ovarian stimulation cycle...
June 22, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28667918/the-inverse-association-of-hdl-cholesterol-with-future-risk-of-hypertension-is-not-modified-by-its-antioxidant-constituent-paraoxonase-1-the-prevend-prospective-cohort-study
#4
Setor K Kunutsor, Lyanne M Kieneker, Stephan J L Bakker, Richard W James, Robin P F Dullaart
BACKGROUND AND AIMS: High-density lipoprotein cholesterol (HDL-C), an established risk marker for atherosclerotic cardiovascular disease (CVD), has been shown to be inversely and independently associated with incident hypertension. Paraoxonase-1 (PON-1) is an HDL-bound esterase enzyme associated with CVD, but its relationship with incident hypertension has not been previously investigated. We aimed at evaluating the prospective association between PON-1 and hypertension risk. METHODS: PON-1 arylesterase activity was measured in serum at baseline in 3988 participants without pre-existing hypertension in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective population-based study...
June 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28665493/assessment-of-the-inhibitory-effects-and-molecular-docking-of-some-sulfonamides-on-human-serum-paraoxonase-1
#5
Zuhal Alim, Deryanur Kilic, Zeynep Koksal, Sukru Beydemir, Hasan Ozdemir
Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Due to the PON1's crucial functions, inhibitors and activators of PON1 must be known for pharmacological applications. In this study, we investigated the in vitro effects of some sulfonamides compounds on human serum PON1 (hPON1). For this aim, we purified the hPON1 from human serum with high specific activity by using simple chromatographic methods, and after the purification processes, we investigated in vitro interactions between the enzyme and some sulfonamides (2-amino-5-methyl-1,3-benzenedisulfonamide, 2-chloro-4-sülfamoilaniline, 4-amino-3-methylbenzenesulfanilamide, sulfisoxazole, sulfisomidine, and 5-amino-2-methylbenzenesulfonamide)...
June 30, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28662934/high-triglycerides-and-low-high-density-lipoprotein-cholesterol-lipid-profile-in-rheumatoid-arthritis-a-potential-link-among-inflammation-oxidative-status-and-dysfunctional-high-density-lipoprotein
#6
Javier Rodríguez-Carrio, Mercedes Alperi-López, Patricia López, Raquel López-Mejías, Sara Alonso-Castro, Francisco Abal, Francisco J Ballina-García, Miguel Á González-Gay, Ana Suárez
BACKGROUND: The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. OBJECTIVES: Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TG(high)HDL(low)) in RA...
June 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28660014/apolipoprotein-e-a-multifunctional-protein-with-implications-in-various-pathologies-as-a-result-of-its-structural-features
#7
REVIEW
Irina Florina Tudorache, Violeta Georgeta Trusca, Anca Violeta Gafencu
Apolipoprotein E (apoE), a 34 kDa glycoprotein, mediates hepatic and extrahepatic uptake of plasma lipoproteins and cholesterol efflux from lipid-laden macrophages. In humans, three structural different apoE isoforms occur, with subsequent functional changes and pathological consequences. Here, we review data supporting the involvement of apoE structural domains and isoforms in normal and altered lipid metabolism, cardiovascular and neurodegenerative diseases, as well as stress-related pathological states...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28657841/association-between-dementia-and-vascular-disease-associated-polymorphisms-in-a-tunisian-population
#8
Hamdouni Haithem, Achour Ons, Naija Salma, Rejeb Jihène, Aounallah Mariam, Mhiri Mariem, Noureddine Mariem, Ben Rejeb Nabila, Omezzine Asma, Ben Amor Sana, Benammou Sofien, Bouslama Ali
Dementia is a multifactorial idiopathic pathology caused by clinical, environmental and genetic factors. Hence its etiology is still unknown. We aimed to evaluate the association between five genetic risk factors for vascular diseases and dementia individually and when gathered in haplotypes. We enrolled 200 dementia patients and 300 controls. All subjects were genotyped for vascular disease-associated polymorphisms in the genes coding for Apolipoprotein-E (ApoE), Angiotensin Converting Enzyme (ACE) and Paraoxonase-1 (PON1)...
June 28, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28657647/influences-of-pon1-on-airway-inflammation-and-remodeling-in-bronchial-asthma
#9
Wei-Qiang Chen, Zuo-Zhou Xie, Xiang Wang, Jin-Hong Zhao, Qin Hu, Ying-Hua Chen, Wen-Yong Gao, Yi Liu
This study aims to explore the influences of Paraoxonase-1 (PON1) involved in airway inflammation and remodeling in asthma. Mice were divided into control, asthma, asthma + PON1 and asthma + NC groups, and asthma models were established via aerosol inhalation of ovalbumin (OVA). HE, Masson and PAS stains were used to observe airway inflammation and remodeling, Giemsa staining to assess inflammatory cells in bronchoalveolar lavage fluid (BALF), qRT-PCR and western blot to detect PON1 expression, lipid peroxidation and glutathione assays to quantify malondialdehyde (MDA) activity and glutathione peroxidase (GSH) levels, ELISA to determine inflammatory cytokines and immunoglobulin, and colorimetry to detect PON1 activities...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28648695/the-usefulness-of-advanced-lipid-and-oxidative-stress-testing-for-diagnosis-and-management-of-low-hdl-cholesterol-phenotype-a-case-report
#10
Vladimir Kuburovic, Jelena Vekic, Aleksandra Zeljkovic, Alain Carrie, Jelena Kotur-Stevuljevic, Dragana Bojanin, Jovan Kosutic, Vesna Spasojevic-Kalimanovska, Milica Miljkovic, Nina Kuburovic, Philippe Couvert
OBJECTIVE: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype...
June 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28647186/bougainvillea-spectabilis-flowers-extract-protects-against-the-rotenone-induced-toxicity
#11
Omar M E Abdel-Salam, Eman R Youness, Nadia A Ahmed, Sayed A El-Toumy, Ahmed M A Souleman, Nermeen Shaffie, Dalia M Abouelfadl
OBJECTIVE: To investigate the effect of two extracts of Bougainvillea spectabilis (B. spectabilis) flowers with yellow and pink/purple on brain oxidative stress and neuronal damage caused in rats by systemic rotenone injection. METHODS: Rotenone 1.5 mg/kg was given three times per week alone or in combination with B. spectabilis flowers extracts (25 mg or 50 mg) via the subcutaneous route for 2 weeks. Brain concentrations of the lipid peroxidation marker malondialdehyde (MDA), reduced glutathione, nitric oxide (nitrite), the pro-inflammatory cytokine interleukin-1beta (Il-1β) as well as butyrylcholinesterase, and paraoxonase-1 (PON-1) activities, were determined...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28645072/association-of-the-serum-myeloperoxidase-high-density-lipoprotein-particle-ratio-and-incident-cardiovascular-events-in-a-multi-ethnic-population-observations-from-the-dallas-heart-study
#12
Htet W Khine, John F Teiber, Robert W Haley, Amit Khera, Colby R Ayers, Anand Rohatgi
BACKGROUND AND AIMS: Myeloperoxidase (MPO), a product of systemic inflammation, promotes oxidation of lipoproteins; whereas, high-density lipoprotein (HDL) exerts anti-oxidative effects in part via paraoxonase-1 (PON1). MPO induces dysfunctional HDL particles; however, the interaction of circulating levels of these measures in cardiovascular disease (CVD) has not been studied in humans. We tested whether serum levels of MPO indexed to HDL particle concentration (MPO/HDLp) are associated with increased CVD risk in a large multiethnic population sample, free of CVD at baseline...
June 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28640711/effects-of-season-and-postmortem-changes-on-blood-analytes-in-pyrenean-chamois-rupicapra-pyrenaica
#13
Asta Tvarijonaviciute, Ignasi Marco, Rafaela Cuenca, Santiago Lavín, Josep Pastor
Our objectives were to evaluate the effects of the 1) season, and 2) postmortem changes on serum biochemistries related with metabolism in Pyrenean chamois (Rupicapra pyrenaica pyrenaica). Serum samples from 98 animals obtained from 2009 to 2012 were included. To investigate seasonal influences on blood parameters, the Pyrenean chamois were captured in drive-nets during the feed abundant (FA; n=32) and food deficient (FD; n=35) seasons. To evaluate the possible differences in biochemistry analytes when sampling live or dead animals, we used serum samples from 32 captured animals and 31 dead animals (obtained during controlled hunting) in the FA season...
June 22, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28631083/is-there-a-relationship-between-serum-ox-ldl-oxidative-stress-and-pon1-in-knee-osteoarthritis
#14
Cemil Ertürk, Mehmet Akif Altay, Ali Bilge, Hakim Çelik
Previous in vitro studies have shown that oxidized low-density lipoprotein (ox-LDL) plays a role in the pathogenesis of osteoarthritis (OA). Paraoxonase-1 (PON1) protects both low-density lipoproteins (LDLs) and high-density lipoprotein (HDLs) against oxidative damage from circulating cells. In addition, PON1 is inactivated by ox-LDL and preserved by antioxidants. However, the relationship between serum ox-LDL, oxidative stress, and PON1 in knee OA remains unclear. Therefore, we investigated ox-LDL association with oxidative stress and PON1 in knee OA, and evaluated their relationships using radiological and clinical parameters...
June 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28623808/role-of-polyphenols-and-polyphenol-rich-foods-in-the-modulation-of-pon1-activity-and-expression
#15
REVIEW
Daniela Martini, Cristian Del Bo', Marisa Porrini, Salvatore Ciappellano, Patrizia Riso
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme involved in the protection of low-density lipoprotein and HDLs against lipid peroxidation. Several studies documented the capacity of polyphenols to stimulate PON1 transcription activation. The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity. A total of 76 in vitro and in vivo studies were included in the review...
June 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28623707/the-role-of-pon-1-gr-il-18-and-oxldl-in-depression-with-and-without-posttraumatic-stress-disorder
#16
Ewa A Ogłodek
BACKGROUND: Both oxidative stress markers and inflammatory markers are important when diagnosing depression. Oxidative stress occurs due to an imbalance between free radical generation and antioxidant potential. Both adenosine triphosphate and reactive oxygen/nitrogen species are released during oxidative phosphorylation. When neuroinflammation and free radical production are increased, oxidative stress occurs and causes damage to all major cellular macromolecules. The aim of the study was to compare the concentrations of paraoxonase-1 (PON-1), glutathione reductase (GR), interleukin-18 (IL-18), and oxidized low-density lipoproteins (OxLDL) in depressed patients with and without posttraumatic stress disorder (PTSD), and PTSD alone...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28613450/chemical-composition-and-biological-studies-of-the-essential-oil-from-aerial-parts-of-beta-vulgaris-subsp-maritima-l-arcang-growing-in-tunisia
#17
Afifa Zardi-Bergaoui, Aymen Ben Nejma, Fethia Harzallah-Skhiri, Guido Flamini, Roberta Ascrizzi, Hichem Ben Jannet
The chemical composition, antioxidant, cytotoxic, anticholinesterase and anti-tyrosinase activities of the hydrodistilled essential oil of the aerial parts of Beta vulgaris subsp. Maritime (L.) Arcang. from Tunisia have been evaluated. The chemical composition of the oil (yield 0.037% (w/w)), determined by GC-FID and GC-MS is reported for the first time. Twenty five components, accounting for 98.1% of the total oil have been identified. The oil was characterized by a high proportion of oxygenated sesquiterpenes (39...
June 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28611113/active-paraoxonase-1-is-synthesised-throughout-the-internal-boar-genital-organs
#18
Isabel Barranco, Cristina Perez-Patiño, Asta Tvarijonaviciute, Inmaculada Parrilla, Alejandro Vicente-Carrillo, Manuel Alvarez-Rodriguez, Jose J Ceron, Emilio Martinez, Heriberto Rodriguez-Martinez, Jordi Roca
The paraoxonase type 1 (PON1) is an enzyme with antioxidant properties recently identified in the seminal plasma (SP) of several species, including the porcine. The aims of the present study were to (1) describe the inmunohistochemical localization of PON1 in the genital organs of fertile boars and (2) evaluate the relationship among PON1 activity and high-density lipoprotein cholesterol (HDL-C) concentration in fluids of the boar genital organs. Immunohistochemical analysis demonstrated that PON1 was present in testis (specifically in Leydig cells, blood vessels, spermatogonia and elongated spermatids), epididymis (specifically in the cytoplasm of the principal epithelial cells, luminal secretion and in the surrounding smooth muscle) and the lining epithelia of the accessory sexual glands (cytoplasmic location in the prostate and membranous in the seminal vesicle and bulbourethral glands)...
June 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28608804/phytosterols-and-omega-3-supplementation-exert-novel-regulatory-effects-on-metabolic-and-inflammatory-pathways-a-proteomic-study
#19
Carmen Lambert, Judit Cubedo, Teresa Padró, Joan Sánchez-Hernández, Rosa M Antonijoan, Antonio Perez, Lina Badimon
Cardiovascular disease (CVD) remains one of the major causes of death and disability worldwide. In addition to drug treatment, nutritional interventions or supplementations are becoming a health strategy for CVD prevention. Phytosterols (PhyS) are natural components that have been shown to reduce cholesterol levels; while poly-unsaturated fatty acids (PUFA), mainly omega-3 (ω3) fatty acids, have shown to reduce triglyceride levels. Here we aimed to investigate whether the proteins in the main lipoproteins (low density lipoproteins (LDL) and high density lipoproteins (HDL)) as well as proteins in the lipid free plasma fraction (LPDP) were regulated by the intake of PhyS-milk or ω3-milk, in overweight healthy volunteers by a proteomic based systems biology approach...
June 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28606327/evaluation-of-oxidant-antioxidant-balance-in-iberian-ibex-capra-pyrenaica-experimentally-infested-with-sarcoptes-scabiei
#20
José Espinosa, Jesús M Pérez, Jorge R López-Olvera, Arián Ráez-Bravo, Francisco J Cano-Manuel, Paulino Fandos, Ramón C Soriguer, José Enrique Granados, Diego Romero
Oxidative stress (OS) is an imbalance between radical-generating and radical scavenging activity, resulting in oxidation products and tissue damage. Although some studies have been done in other species, there is a lack of information about the oxidative/antioxidant status in the Iberian ibex (Capra pyrenaica) affected by sarcoptic mange. To clarify this fact, albumin, catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), paraoxonase-1 (PON-1), glutathione reductase (GR), reduced glutathione (GSH): oxidized glutathione (GSSG) ratio, thiobarbituric acid reactive substances (TBARS) and total oxidant status (TOS) concentrations were measured in peripheral blood of ibexes experimentally infested with Sarcoptes scabiei (n=25), as well as in the healthy control group (n=14)...
August 15, 2017: Veterinary Parasitology
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