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paraoxonase 1

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https://www.readbyqxmd.com/read/28077734/intake-of-up-to-3-eggs-per-day-is-associated-with-changes-in-hdl-function-and-increased-plasma-antioxidants-in-healthy-young-adults
#1
Diana M DiMarco, Gregory H Norris, Courtney L Millar, Christopher N Blesso, Maria Luz Fernandez
BACKGROUND: HDL function may be more important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation. OBJECTIVE: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population. METHODS: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m(2)) 18...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28070599/organophosphate-neurotoxicity-to-the-voluntary-motor-system-on-the-trail-of-environment-caused-amyotrophic-lateral-sclerosis-the-known-the-misknown-and-the-unknown
#2
Samantha J Merwin, Teresa Obis, Yanelli Nunez, Diane B Re
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder. It is characterized by progressive degeneration of the motor neurons controlling voluntary movement. The underlying mechanisms remain elusive, a fact that has precluded development of effective treatments. ALS presents as a sporadic condition 90-95% of the time, i.e., without familial history or obvious genetic mutation. This suggests that ALS has a strong environmental component. Organophosphates (OPs) are prime candidate neurotoxicants in the etiology of ALS, as exposure to OPs was linked to higher ALS incidence among farmers, soccer players, and Gulf War veterans...
January 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28032682/antiepileptic-drugs-impacts-on-human-serum-paraoxonase-1
#3
Şükrü Beydemir, Yeliz Demir
Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro inhibition role of some antiepileptic drugs (AEDs) such as valproic acid, gabapentin, primidone, phenytoin, and levetiracetam on human paraoxonase (hPON1). Therefore, PON1 was purified from human serum with a specific activity of 3976.36 EU/mg and 13.96% yield by using simple chromatographic methods...
December 29, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28027289/paraoxonase-1-pon1-rs662-polymorphism-and-its-association-with-serum-lipid-levels-and-longevity-in-the-bama-zhuang-population
#4
You Li, Guiyun Liang, Liwei Shi, Xue Liang, Bingshuang Long, Jian Qin, Zhiyong Zhang
BACKGROUND The present study was performed to identify the association of PON1 rs662 polymorphism with serum lipid levels and human longevity in the Bama Zhuang population. MATERIAL AND METHODS PON1 genotypes were determined by Taqman SNP Genotyping Assays in 110 long-lived inhabitants (longevity group, aged 90-110 years), 110 healthy inhabitants in Bama County (control 1 group, aged 43-82 years) and 110 healthy inhabitants in Nandan County (control 2 group, aged 28-82 years) without family history of longevity...
December 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28026940/active-site-hydrophobicity-and-the-convergent-evolution-of-paraoxonase-activity-in-structurally-divergent-enzymes-the-case-of-serum-paraoxonase-1
#5
David Blaha-Nelson, Dennis M Krüger, Klaudia Szeler, Moshe Ben-David, Shina Caroline Lynn Kamerlin
Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Structurally, PON1 is a six-bladed β-propeller with a flexible loop (residues 70-81) covering the active site. This loop contains a functionally critical Tyr at position 71. We have performed detailed experimental and computational analyses of the role of selected Y71 variants in the active site stability and catalytic activity in order to probe the role of Y71 in PON1's lactonase and organophosphatase activities...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28017774/identification-of-esterase-involved-in-the-metabolism-of-two-corticosteroid-soft-drugs
#6
Ahmed Samir, Nicholas Bodor, Teruko Imai
The soft drug approach is successful in obtaining high local therapeutic efficacy without systemic adverse effects, because soft drugs are designed to be bioconverted to inactive form by hydrolytic enzymes in systemic circulation. However, there is little information about the exact nature of these metabolic enzymes. In this study, the human enzymes for biotransformation of soft drugs were investigated. Loteprednol etabonate (LE) and etiprednol dicloacetate (ED) were designed from Δ(1)-cortienic acid (Δ(1)-CA), the inactive metabolite of prednisolone, by introducing two labile ester bonds to restore the corticosteroidal activity...
December 22, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27979226/fractionation-enzyme-inhibitory-and-cellular-antioxidant-activity-of-bioactives-from-purple-sweet-potato-ipomoea-batatas
#7
Tuba Esatbeyoglu, Miriam Rodríguez-Werner, Anke Schlösser, Peter Winterhalter, Gerald Rimbach
Sweet potato (Ipomoea batatas L.) is mainly cultivated in Asia. The deep purple color of purple sweet potato (PSP) is due to the high content of acylated anthocyanins. In the present study, PSP-derived polyphenols were identified using HPLC-PDA and HPLC-ESI-MS(n) analyses. After concentration of the polyphenols from PSP, preparative separation into two fractions, designated anthocyanins (AF) and copigments (CF), was carried out using adsorptive membrane chromatography. In enzyme inhibitory assays, all PSP samples inhibited the enzymes α-amylase, α-glucosidase and xanthine oxidase...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27959408/involvement-of-xanthine-oxidase-and-paraoxonase-1-in-the-process-of-oxidative-stress-in-nonalcoholic-fatty-liver-disease
#8
Bing Wang, Rui-Ning Yang, Yue-Rong Zhu, Ji-Cheng Xing, Xiao-Wei Lou, Yu-Jie He, Qi-Long Ding, Ming-Yue Zhang, Hong Qiu
Xanthine oxidase (XOD) and paraoxonase 1 (PON1) are important enzymes in redox reactions in vivo, and are predominantly synthesized by the liver. The aim of the present study was to investigate the redox state in nonalcoholic fatty liver disease, and determine the association between the activities of XOD and PON1 and the severity of NAFLD. Sprague‑Dawley rats were randomly divided into control, model and α‑lipoic acid (high and low dose) groups. The rats in the NAFLD model were induced by feeding a high fat diet for 12 weeks and the in vitro cell model of hepatocyte steatosis was induced by treating L‑02 cells with oleic acid for 24 h...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27955746/novel-neuroprotective-and-hepatoprotective-effects-of-citric-acid-in-acute-malathion-intoxication
#9
Omar M E Abdel-Salam, Eman R Youness, Nadia A Mohammed, Noha N Yassen, Yasser A Khadrawy, Safinaz Ebrahim El-Toukhy, Amany A Sleem
OBJECTIVE: To study the effect of citric acid given alone or combined with atropine on brain oxidative stress, neuronal injury, liver damage, and DNA damage of peripheral blood lymphocytes induced in the rat by acute malathion exposure. METHODS: Rats were received intraperitoneal (i.p.) injection of malathion 150 mg/kg along with citric acid (200 or 400 mg/kg, orally), atropine (1 mg/kg, i.p.) or citric acid 200 mg/kg + atropine 1 mg/kg and euthanized 4 h later...
December 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27936340/high-morning-blood-pressure-surge-is-associated-with-oxidative-stress-and-paraoxonase-1-activity-in-newly-diagnosed-hypertensive-patients
#10
Onur Kaypaklı, Mustafa Gür, Hazar Harbalıoğlu, Taner Şeker, Şahabettin Selek
BACKGROUND: Both oxidative stress and morning surge (MS) of blood pressure (BP) were found to be closely related with cardiovascular and cerebrovascular diseases. We investigated the association between MS of BP and oxidative stress in newly diagnosed hypertensive patients. METHODS: We prospectively included 237 newly diagnosed hypertensive patients in the present study (mean age: 51.6 ± 11.7 years). The patients were classified according to the extent of the sleep-through surge as follows: the top decile of sleep-through surge (>47...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27934969/quantitative-hdl-proteomics-identifies-peroxiredoxin-6-as-a-biomarker-of-human-abdominal-aortic-aneurysm
#11
Elena Burillo, Inmaculada Jorge, Diego Martínez-López, Emilio Camafeita, Luis Miguel Blanco-Colio, Marco Trevisan-Herraz, Iakes Ezkurdia, Jesús Egido, Jean-Baptiste Michel, Olivier Meilhac, Jesús Vázquez, Jose Luis Martin-Ventura
High-density lipoproteins (HDLs) are complex protein and lipid assemblies whose composition is known to change in diverse pathological situations. Analysis of the HDL proteome can thus provide insight into the main mechanisms underlying abdominal aortic aneurysm (AAA) and potentially detect novel systemic biomarkers. We performed a multiplexed quantitative proteomics analysis of HDLs isolated from plasma of AAA patients (N = 14) and control study participants (N = 7). Validation was performed by western-blot (HDL), immunohistochemistry (tissue), and ELISA (plasma)...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923688/paraoxonase-3-promotes-cell-proliferation-and-metastasis-by-pi3k-akt-in-oral-squamous-cell-carcinoma
#12
Lili Zhu, Yiyin Shen, Wei Sun
Paraoxonase 3 (PON3) is an oncogene in cancer, however, little is known about the mechanisms and roles of PON3 in oral squamous cell carcinoma (OSCC), which is the aim of our study. We found that the expression of PON3 was up-regulated in OSCC samples and cell lines. PON3 was associated with accelerating cell proliferation, cell cycle, migration and invasion in OSCC cells. Further research showed that PON3 was regulated by PI3K/Akt pathway. We also found that AP-1 was an important transcriptional factor regulating PON3 expression in OSCC...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27914538/adaptive-response-of-rat-pancreatic-%C3%AE-cells-to-insulin-resistance-induced-by-monocrotophos-biochemical-evidence
#13
Raju Nagaraju, Padmanabhan Sharda Rajini
Our previous findings clearly suggested the role of duration of exposure to monocrotophos (MCP) in the development of insulin resistance. Rats exposed chronically to MCP developed insulin resistance with hyperinsulinemia without overt diabetes. In continuation of this vital observation, we sought to delineate the biochemical mechanisms that mediate heightened pancreatic β-cell response in the wake of MCP-induced insulin resistance in rats. Adult rats were orally administered (0.9 and 1.8mg/kgb.w/d) MCP for 180days...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27892863/nutrigenomic-activity-of-plant-derived-compounds-in-health-and-disease-results-of-a-dietary-intervention-study-in-dog
#14
Sandy Sgorlon, Bruno Stefanon, Misa Sandri, Monica Colitti
The study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. Seventy four dogs were enrolled in the trials, 24 healthy dogs were fed with a control diet (CT) and the experimental groups received for 60days the same diet supplemented with nutraceuticals, namely Echinacea angustifolia (EA, 0.10mg/kg live weight as echinacoside; 14 dogs), Vaccinium myrtillus (VM, 0.20mg/kg live weight as anthocyanidin, 13 dogs), Curcuma longa (CL, 6.60mg/kg live weight as curcumin, 18 dogs with arthrosis), and Sylibum marianum (SM, 1...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27891663/extended-release-niacin-increases-anti-apoa-i-antibodies-that-block-the-anti-oxidant-effect-of-hdl-c-the-explore-clinical-trial
#15
J R Batuca, M C Amaral, C Favas, F S Paula, P R J Ames, A L Papoila, J Delgado Alves
AIMS: Extended Release-Niacin (ERN) is the most effective agent for increasing high-density lipoprotein-cholesterol (HDL-C). Having previously identified anti-HDL antibodies, we investigated whether ERN affected the antioxidant capacity of HDL and whether ERN was associated with the production of antibodies against HDL (aHDL) and apolipoprotein A-I (aApoA-I). METHODS: Twenty-one patients older than 18 years, with HDL-C ≤ 40 mg/dL (men) or ≤ 50 mg/dL (women) were randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over...
November 27, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27890370/acetylcholinesterase-butyrylcholinesterase-and-paraoxonase-1-activities-in-rats-treated-with-cannabis-tramadol-or-both
#16
Omar M E Abdel-Salam, Eman R Youness, Yasser A Khadrawy, Amany A Sleem
OBJECTIVE: To investigate the effect of Cannabis sativa resin and/or tramadol, two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these agents. METHODS: Rats were treated with cannabis resin (5, 10 or 20 mg/kg) (equivalent to the active constituent Δ(9)-tetrahydrocannabinol), tramadol (5, 10 and 20 mg/kg) or tramadol (10 mg/kg) combined with cannabis resin (5, 10 and 20 mg/kg) subcutaneously daily for 6 weeks...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27881290/mercury-eicosapentanoic-acid-and-docosahexaenoic-acid-demonstrate-limited-effect-on-plasma-paraoxonase-1-activity-and-blood-pressure-among-avid-seafood-consumers-in-the-long-island-study-of-seafood-consumption-ny-usa
#17
Charles Miller, Roxanne Karimi, Qiao Zhang, Jie Yang, Jaymie Meliker
BACKGROUND AND AIM: Moderate fish consumption is recommended for prevention of coronary heart disease (CHD) as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have known beneficial effects on risk factors such as reducing blood pressure (BP) and increasing paraoxonase-1 (PON-1) activity. However concomitant methylmercury (MeHg) exposure from fish consumption may mitigate these benefits and the net effect on BP and PON-1 activity has not been extensively studied in western populations consuming diverse seafood types...
November 17, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27878751/assessment-of-the-relationship-between-serum-paraoxonase-activity-and-epicardial-adipose-tissue-in-hemodialysis-patients
#18
Emad Abdallah, Samya El-Shishtawy, Nevine Sherif, Ahmed Ali, Omnia El-Bendary
PURPOSE: Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease...
November 23, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27869741/isoliquiritigenin-attenuates-atherogenesis-in-apolipoprotein-e-deficient-mice
#19
Fen Du, Quzhen Gesang, Jia Cao, Mei Qian, Li Ma, Dongfang Wu, Hong Yu
Isoliquiritigenin (ISL) exhibits antioxidation and anti-inflammation activity. We sought to investigate the effects and mechanism of ISL on the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice. Firstly, we determined that ISL reduced the mRNA levels of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and monocyte chemotactic protein-1 (MCP-1), while it increased the expression of several lipoprotein-related genes in peritoneal macrophages treated with lipopolysaccharide (LPS)...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27865893/sex-and-genetic-differences-in-the-effects-of-acute-diesel-exhaust-exposure-on-inflammation-and-oxidative-stress-in-mouse-brain
#20
Toby B Cole, Jacki Coburn, Khoi Dao, Pam Roqué, Yu-Chi Chang, Vrinda Kalia, Tomas R Guilarte, Jennifer Dziedzic, Lucio G Costa
In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component. DE contains more than 40 toxic air pollutants and is a major constituent of ambient particulate matter (PM), particularly of ultrafine-PM. Limited information suggests that exposure to DE may cause oxidative stress and neuroinflammation in the CNS...
December 30, 2016: Toxicology
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