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framingham heart study

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https://www.readbyqxmd.com/read/28431980/shear-stress-alterations-in-the-celiac-trunk-of-patients-with-a-continuous-flow-left-ventricular-assist-device-as-shown-by-in-silico-and-in-vitro-flow-analyses
#1
Francesco Scardulla, Salvatore Pasta, Leonardo D'Acquisto, Sergio Sciacca, Valentina Agnese, Christian Vergara, Alfio Quarteroni, Francesco Clemenza, Diego Bellavia, Michele Pilato
BACKGROUND: The use of left ventricular assist devices (LVADs) to treat advanced cardiac heart failure is constantly increasing, although this device leads to high risk for gastrointestinal bleeding. METHODS: Using in-silico flow analysis, we quantified hemodynamic alterations due to continuous-flow LVAD (HeartWare, Inc., Framingham, MA) in the celiac trunk and major branches of the abdominal aorta, and then explored the relationship between wall shear stress (WSS) and celiac trunk orientation...
March 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28430902/risk-for-hypertension-crosses-generations-in-the-community-a-multi-generational-cohort-study
#2
Teemu J Niiranen, Elizabeth L McCabe, Martin G Larson, Mir Henglin, Neal K Lakdawala, Ramachandran S Vasan, Susan Cheng
Aims: Parental hypertension is known to predict high blood pressure (BP) in children. However, the extent to which risk for hypertension is conferred across multiple generations, notwithstanding the impact of environmental factors, is unclear. Our objective was therefore to evaluate the degree to which risk for hypertension extends across multiple generations of individuals in the community. Methods and results: We studied three generations of Framingham Heart Study participants with standardized blood pressure measurements performed at serial examinations spanning 5 decades (1948 through 2005): First Generation (n = 1809), Second Generation (n = 2631), and Third Generation (n = 3608, mean age 39 years, 53% women)...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28428346/sugar-and-artificially-sweetened-beverages-and-the-risks-of-incident-stroke-and-dementia-a-prospective-cohort-study
#3
Matthew P Pase, Jayandra J Himali, Alexa S Beiser, Hugo J Aparicio, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri, Paul F Jacques
BACKGROUND AND PURPOSE: Sugar- and artificially-sweetened beverage intake have been linked to cardiometabolic risk factors, which increase the risk of cerebrovascular disease and dementia. We examined whether sugar- or artificially sweetened beverage consumption was associated with the prospective risks of incident stroke or dementia in the community-based Framingham Heart Study Offspring cohort. METHODS: We studied 2888 participants aged >45 years for incident stroke (mean age 62 [SD, 9] years; 45% men) and 1484 participants aged >60 years for incident dementia (mean age 69 [SD, 6] years; 46% men)...
April 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28412431/3d-morphological-changes-in-lv-and-rv-during-lvad-ramp-studies
#4
Karima Addetia, Nir Uriel, Francesco Maffessanti, Gabriel Sayer, Sirtaz Adatya, Gene H Kim, Nitasha Sarswat, Savitri Fedson, Diego Medvedofsky, Eric Kruse, Keith Collins, Daniel Rodgers, Takayoshi Ota, Valluvan Jeevanandam, Victor Mor-Avi, Daniel Burkhoff, Roberto M Lang
OBJECTIVES: The purpose of this study was to investigate the differential impact of the 2 most commonly available left ventricular assist device (LVAD) types on the right (RV) and left (LV) ventricles using 3-dimensional (3D) echocardiography-based analysis of ventricular morphology. BACKGROUND: LVADs have emerged as common therapy for advanced heart failure. Recent data suggest that the heart responds differently to speed settings in the 2 main devices available (HeartMate II [HMII], St Jude Medical, Pleasanton, California, and HVAD, HeartWare International, Framingham, Massachusetts)...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28404965/impact-of-statins-therapy-on-morphological-changes-in-lipid-rich-plaques-stratified-by-10-year-framingham-risk-score-a-serial-optical-coherence-tomography-study
#5
Yinchun Zhu, Lin Lin, Chao Wang, Haibo Jia, Sining Hu, Lulu Li, Xiling Zhang, Gonghui Zheng, Yan Wang, Rong Sun, Abigail Afolabi, Irina Mustafina, Jingbo Hou, Shaosong Zhang, Bo Yu
The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52)...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28397943/anthropometric-and-central-obesity-indices-as-predictors-of-long-term-cardiometabolic-risk-among-saudi-young-and-middle-aged-men-and-women
#6
Mahmoud M A Abulmeaty, Ali M Almajwal, Najwa K Almadani, Mona S Aldosari, Ahmed A Alnajim, Saeed B Ali, Heba M Hassan, Hany A Elkatawy
To investigate the prediction of long-term cardiometabolic risk using anthropometric and central obesity parameters.  Methods: A total of 390 Saudi subjects (men 42.8%) aged 18-50 years were enrolled in a cross-sectional study in King Saud University, Riyadh, Kingdom of Saudi Arabia between August 2014 and  January 2016. All   participants were instructed to fast for 12 hours before taking blood samples for glucose and lipid panel analyses. A full anthropometric measurement and bioelectric impedance analysis was performed...
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28396534/aortic-brachial-arterial-stiffness-gradient-and-cardiovascular-risk-in-the-community-the-framingham-heart-study
#7
Teemu J Niiranen, Bindu Kalesan, Martin G Larson, Naomi M Hamburg, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan
A recent study reported that the aortic-brachial arterial stiffness gradient, defined as carotid-radial/carotid-femoral pulse wave velocity (PWV ratio), predicts all-cause mortality better than carotid-femoral pulse wave velocity (CFPWV) alone in dialysis patients. However, the prognostic significance of PWV ratio for cardiovascular disease (CVD) in the community remains unclear. Accordingly, we assessed the correlates and prognostic value of the PWV ratio in 2114 Framingham Heart Study participants (60±10 years; 56% women) free of overt CVD...
April 10, 2017: Hypertension
https://www.readbyqxmd.com/read/28388431/induced-pluripotent-stem-cell-differentiation-enables-functional-validation-of-gwas-variants-in-metabolic-disease
#8
Curtis R Warren, John F O'Sullivan, Max Friesen, Caroline E Becker, Xiaoling Zhang, Poching Liu, Yoshiyuki Wakabayashi, Jordan E Morningstar, Xu Shi, Jihoon Choi, Fang Xia, Derek T Peters, Mary H C Florido, Alexander M Tsankov, Eilene Duberow, Lauren Comisar, Jennifer Shay, Xin Jiang, Alexander Meissner, Kiran Musunuru, Sekar Kathiresan, Laurence Daheron, Jun Zhu, Robert E Gerszten, Rahul C Deo, Ramachandran S Vasan, Christopher J O'Donnell, Chad A Cowan
Genome-wide association studies (GWAS) have highlighted a large number of genetic variants with potential disease association, but functional analysis remains a challenge. Here we describe an approach to functionally validate identified variants through differentiation of induced pluripotent stem cells (iPSCs) to study cellular pathophysiology. We collected peripheral blood cells from Framingham Heart Study participants and reprogrammed them to iPSCs. We then differentiated 68 iPSC lines into hepatocytes and adipocytes to investigate the effect of the 1p13 rs12740374 variant on cardiometabolic disease phenotypes via transcriptomics and metabolomic signatures...
April 6, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28384154/structured-mating-patterns-and-implications
#9
Ronnie Sebro, Gina M Peloso, Josée Dupuis, Neil J Risch
Genetic similarity of spouses can reflect factors influencing mate choice, such as physical/behavioral characteristics, and patterns of social endogamy. Spouse correlations for both genetic ancestry and measured traits may impact genotype distributions (Hardy Weinberg and linkage equilibrium), and therefore genetic association studies. Here we evaluate white spouse-pairs from the Framingham Heart Study (FHS) original and offspring cohorts (N = 124 and 755, respectively) to explore spousal genetic similarity and its consequences...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28373783/analysis-of-three-risk-stratification-systems-in-a-saudi-population
#10
Rami Abazid, Hanna Al Saqqa, Osama Smettei
INTRODUCTION: Coronary artery disease is the leading cause of death worldwide. Although there are a number of algorithms in use for determining the risk of coronary artery disease and thus predicting future cardiovascular events, the data available regarding their validity among the Saudi population are insufficient. OBJECTIVE: We studied the validity of three clinical score systems in predicting a high risk population defined as having excessive coronary calcification: the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Risk Equation, the Framingham Risk Score, and the European Systematic Coronary Risk Evaluation...
April 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28373293/lipid-metabolism-and-its-implications-for-type-1-diabetes-associated-cardiomyopathy
#11
Rebecca H Ritchie, Eser J Zerenturk, Darnel Prakoso, Anna C Calkin
Diabetic cardiomyopathy was first defined over four decades ago. It was observed in small post-mortem studies of diabetic patients who suffered from concomitant heart failure despite the absence of hypertension, coronary disease or other likely causal factors, as well as in large population studies such as the Framingham Heart Study. Subsequent studies continue to demonstrate an increased incidence of heart failure in the setting of diabetes independent of established risk factors, suggesting direct effects of diabetes on the myocardium...
April 3, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28369989/severity-of-nonalcoholic-fatty-liver-disease-on-sonography-and-risk-of-coronary-heart-disease
#12
Sun Hwa Lee, Seong Jong Yun, Dong Hyeon Kim, Hyeon Hwan Jo, Yong Sung Park
PURPOSE: To evaluate the relationship between nonalcoholic fatty liver disease (NAFLD) on sonography (US) and the risk of coronary heart disease (CHD) as well as the predictive value of US-diagnosed NAFLD to determine intermediate/high CHD risk compared with as well as in combination on with NAFLD fibrosis score (NFS). METHODS: This retrospective study included 1,276 patients examined between November 2015 and August 2016. NAFLD was categorized as absent, mild, moderate, or severe based on liver-to-kidney echogenicity, visibility of intrahepatic vessel walls, and the diaphragm...
March 28, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28364691/incidence-of-seizures-following-initial-ischemic-stroke-in-a-community-based-cohort-the-framingham-heart-study
#13
Maria Stefanidou, Rohit R Das, Alexa S Beiser, Banu Sundar, Margaret Kelly-Hayes, Carlos S Kase, Orrin Devinsky, Sudha Seshadri, Daniel Friedman
PURPOSE: We examined the incidence of seizures following ischemic stroke in a community-based sample. METHODS: All subjects with incident ischemic strokes in the Framingham Original and Offspring cohorts between 1982 and 2003 were identified and followed for up to 20 years to determine incidence of seizures. Seizure-type was based on the 2010 International League Against Epilepsy (ILAE) classification. Disability was stratified into mild/none, moderate and severe, based on post-stroke neurological deficit documentation according to the Framingham Heart Study (FHS) protocol and functional status was determined using the Barthel Index...
April 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28350635/evidence-on-the-validity-of-a-comprehensive-health-risk-index-and-implications-for-ambulatory-care-and-population-health-management
#14
Joseph M Massaro, Joanne M Murabito, Rhoda Au, Emily Carnahan, Tamara S Morgan, Christopher Murray, Elliott S Fisher, Eugene C Nelson, Stephen S Lim, Ralph B DʼAgostino
A novel, comprehensive health risk index for adults has been validated and is now ready for use to improve the health of individuals and populations. This health risk index provides an estimate of the avoidable risk of death for adults 30 years or older. It includes 12 evidence-based clinical and behavioral risk factors and was validated on discrimination and calibration using the NHANES (National Health and Nutrition Examination Survey) and Framingham Heart Study cohorts. The results from both cohorts were consistent and similar...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28347929/cerebral-microbleeds-and-risk-of-incident-dementia-the-framingham-heart-study
#15
José R Romero, Alexa Beiser, Jayandra J Himali, Ashkan Shoamanesh, Charles DeCarli, Sudha Seshadri
Cerebral microbleeds (CMBs) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia: hypertensive and cerebral amyloid angiopathy. CMB detection in asymptomatic persons may help identify those at risk for dementia and may influence preventive strategies and design of clinical trials testing treatments for dementia. We studied the association of CMB with risk of incident dementia in community dwelling individuals. A total of 1296 dementia-free Framingham Heart Study participants (mean age 72 years; 54% women) with available brain MRI and incident dementia data during a mean follow-up period of 6...
March 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28334007/a-functional-variant-in-neph3-gene-confers-high-risk-of-renal-failure-in-primary-hematuric-glomerulopathies-evidence-for-predisposition-to-microalbuminuria-in-the-general-population
#16
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Höhne, Linus A Völker, Thomas Benzing, Patrick H Maxwell, Daniel P Gale, Mathias Gorski, Carsten Böger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible development for a subset of patients on long-term follow-up, through the onset of focal and segmental glomerulosclerosis (FSGS). We hypothesize that genetic modifiers may explain this variability of symptoms. METHODS: We looked in silico for potentially deleterious functional SNPs, using very strict criteria, in all the genes significantly expressed in the slit diaphragm (SD)...
2017: PloS One
https://www.readbyqxmd.com/read/28329787/circulating-estrogen-levels-and-self-reported-health-and-mobility-limitation-in-community-dwelling-men-of-the-framingham-heart-study
#17
Guneet Kaur Jasuja, Thomas G Travison, Joanne M Murabito, Maithili N Davda, Adam J Rose, Shehzad Basaria, Andrea Coviello, Ramachandran S Vasan, Ralph D'Agostino, Shalender Bhasin
Background: Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men. Methods: The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8...
October 24, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28324103/harmonized-reference-ranges-for-circulating-testosterone-levels-in-men-of-four-cohort-studies-in-the-united-states-and-europe
#18
Thomas G Travison, Hubert W Vesper, Eric Orwoll, Frederick Wu, Jean Marc Kaufman, Ying Wang, Bruno Lapauw, Tom Fiers, Alvin M Matsumoto, Shalender Bhasin
Background: Reference ranges for testosterone are essential for making a diagnosis of hypogonadism in men. Objective: To establish harmonized reference ranges for total testosterone in men that can be applied across laboratories by cross-calibrating assays to a reference method and standard. Population: The 9054 community-dwelling men in cohort studies in the United States and Europe: Framingham Heart Study; European Male Aging Study; Osteoporotic Fractures in Men Study; and Male Sibling Study of Osteoporosis...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323826/apoe-related-risk-of-mild-cognitive-impairment-and-dementia-for-prevention-trials-an-analysis-of-four-cohorts
#19
Jing Qian, Frank J Wolters, Alexa Beiser, Mary Haan, M Arfan Ikram, Jason Karlawish, Jessica B Langbaum, John M Neuhaus, Eric M Reiman, J Scott Roberts, Sudha Seshadri, Pierre N Tariot, Beth McCarty Woods, Rebecca A Betensky, Deborah Blacker
BACKGROUND: With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genetic disclosure process of the Alzheimer's Prevention Initiative Generation Study, a prevention trial in cognitively unimpaired APOE-e4/e4 homozygote individuals...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28306696/n-terminal-fragment-of-b-type-natriuretic-peptide-predicts-coexisting-subclinical-heart-and-vessel-disease
#20
Luigi E Pastormerlo, Stefano Maffei, Daniele Della Latta, Vladislav Chubuchny, Carla Susini, Sergio Berti, Concetta Prontera, Simona Storti, Claudio Passino, Emilio Pasanisi, Michele Emdin, Dante Chiappino
BACKGROUND: Identification of preclinical cardiovascular disease represents a challenge. We evaluate N-terminal proB-type natriuretic peptides (NT-proBNP) as markers of both cardiac and vascular subclinical disease in a community-based study including asymptomatic middle- aged study participants. METHODS AND RESULTS: In total, 807 study participants without previous cardiovascular disease were recruited. They underwent thorough laboratory assessment (including NT-proBNP), ultrasound examination of heart and evaluation of coronary calcium score and carotid intima-media thickness, by computed tomography and ultrasound, respectively...
March 16, 2017: Journal of Cardiovascular Medicine
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