keyword
MENU ▼
Read by QxMD icon Read
search

framingham heart study

keyword
https://www.readbyqxmd.com/read/27908389/hypertension-obesity-diabetes-and%C3%A2-heart%C3%A2-failure-free-survival-the-cardiovascular-disease-lifetime-risk-pooling-project
#1
Faraz S Ahmad, Hongyan Ning, Jonathan D Rich, Clyde W Yancy, Donald M Lloyd-Jones, John T Wilkins
OBJECTIVES: This study was designed to quantify the relationship between the absence of heart failure risk factors in middle age and incident heart failure, heart failure-free survival, and overall survival. BACKGROUND: Quantification of years lived free from heart failure in the context of risk factor burden in mid-life may improve risk communication and prevention efforts. METHODS: We conducted a pooled, individual-level analysis sampling from communities across the United States as part of 4 cohort studies: the Framingham Heart, Framingham Offspring, Chicago Heart Association Detection Project in Industry, and ARIC (Atherosclerosis Risk In Communities) studies...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27901176/different-methods-of-calculating-ankle-brachial-index-in-mid-elderly-men-and-women-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#2
M Miname, I M Bensenor, P A Lotufo
The ankle-brachial index (ABI) is a marker of subclinical atherosclerosis related to health-adverse outcomes. ABI is inexpensive compared to other indexes, such as coronary calcium score and determination of carotid artery intima-media thickness (IMT). Our objective was to identify how the ABI can be applied to primary care. Three different methods of calculating the ABI were compared among 13,921 men and women aged 35 to 74 years who were free of cardiovascular diseases and enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27893863/high-vitamin-d-consumption-is-inversely-associated-with-cardiovascular-disease-risk-in-an-urban-mexican-population
#3
Paloma Muñoz-Aguirre, Edgar Denova-Gutiérrez, Mario Flores, Eduardo Salazar-Martínez, Jorge Salmerón
BACKGROUND: Vitamin D deficiency is a major global public health problem. Recent epidemiological studies have assessed the relationship between vitamin D and multiple outcomes, including cardiovascular disease. However, this evidence is limited and inconclusive. Our purpose in this study was to evaluate the association between dietary vitamin D intake and cardiovascular disease risk in adult Mexican population. METHODS: We conducted a cross-sectional analysis with the baseline data from 6294 men and women aged 20-80 years participating in the Health Workers Cohort Study...
2016: PloS One
https://www.readbyqxmd.com/read/27873227/the-relationship-between-aortic-root-size-and-hypertension-an-unsolved-conundrum
#4
Giuseppe Mulè, Emilio Nardi, Massimiliano Morreale, Antonella Castiglia, Giulio Geraci, Dario Altieri, Valentina Cacciatore, Margherita Schillaci, Francesco Vaccaro, Santina Cottone
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques.An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation.Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27870979/coronary-disease-risk-assessment-in-men-comparison-between-ascvd-risk-versus-framingham
#5
Natália Maria Maciel Guerra-Silva, Fernanda Sene Santucci, Ricardo Castanho Moreira, Cristiano Massao Tashima, Simone Cristina Castanho Sabaini de Melo, Leonardo Regis Leira Pereira, Debora de Mello Gonçales Sant'Ana
INTRODUCTION: This study evaluated the risk of men developing coronary heart disease and its determinant variables, comparing these results through two validated coronary risk scales. METHODS: A cross sectional epidemiological analytical study in which data were collected by spontaneous demand, through a semi-structured questionnaire, clinical examination, and blood collection. The Chi-square test, logistic regression and Kappa for statistical analysis were performed...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27863362/comparison-of-cardiovascular-risk-assessment-tools-and-their-guidelines-in-evaluation-of-10-year-cvd-risk-and-preventive-recommendations-a-population-based-study
#6
Nima Motamed, Behnam Rabiee, Dhaya Perumal, Hossein Poustchi, Seyed Javad Haji Miresmail, Behzad Farahani, Mansooreh Maadi, Fatemeh Sima Saeedian, Hossein Ajdarkosh, Mahmood Reza Khonsari, Gholam Reza Hemasi, Farhad Zamani
BACKGROUND: Identification of individuals at risk of cardiovascular diseases (CVDs) results in better clinical outcomes and may help policy makers in conscious decision making for community based and national intervention strategies. The main aim of this study was to compare various CVD risk assessment tools and their related guidelines in estimation of 10-year CVD risk and subsequent therapeutic recommendations, respectively. METHODS: Data of 3086 subjects aged 40-74years from a cohort study of northern Iran were utilized in this cross-sectional study...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861717/a-semiparametric-model-for-vqtl-mapping
#7
Chuan Hong, Yang Ning, Peng Wei, Ying Cao, Yong Chen
Quantitative trait locus analysis has been used as an important tool to identify markers where the phenotype or quantitative trait is linked with the genotype. Most existing tests for single locus association with quantitative traits aim at the detection of the mean differences across genotypic groups. However, recent research has revealed functional genetic loci that affect the variance of traits, known as variability-controlling quantitative trait locus. In addition, it has been suggested that many genotypes have both mean and variance effects, while the mean effects or variance effects alone may not be strong enough to be detected...
November 14, 2016: Biometrics
https://www.readbyqxmd.com/read/27859628/longitudinal-snp-set-association-analysis-of-quantitative-phenotypes
#8
Zhong Wang, Ke Xu, Xinyu Zhang, Xiaowei Wu, Zuoheng Wang
Many genetic epidemiological studies collect repeated measurements over time. This design not only provides a more accurate assessment of disease condition, but allows us to explore the genetic influence on disease development and progression. Thus, it is of great interest to study the longitudinal contribution of genes to disease susceptibility. Most association testing methods for longitudinal phenotypes are developed for single variant, and may have limited power to detect association, especially for variants with low minor allele frequency...
November 9, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27856811/increased-heart-rate-is-associated-with-a-prothrombotic-state-the-framingham-heart-study
#9
Geoffrey H Tofler, Joseph Massaro, Daniel A Levy, Patrice A Sutherland, Thomas Buckley, Ralph B D'Agostino
BACKGROUND: Although a higher heart rate is associated with an increased risk of cardiovascular disease, the mechanism is not well understood. As thrombosis has an important role in plaque development and acute coronary syndromes, the increase related to heart rate may result from a prothrombotic imbalance. METHODS: We investigated the relation between heart rate and thrombotic potential in 3451 participants from the Offspring Cohort of the Framingham Heart Study (mean age 54 years, 55% women)...
November 17, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27846641/prevalence-and-prognostic-implications-of-coronary-artery-calcification-in-low-risk-women-a-meta-analysis
#10
Maryam Kavousi, Chintan S Desai, Colby Ayers, Roger S Blumenthal, Matthew J Budoff, Amir-Abbas Mahabadi, M Arfan Ikram, Aad van der Lugt, Albert Hofman, Raimund Erbel, Amit Khera, Marie H Geisel, Karl-Heinz Jöckel, Nils Lehmann, Udo Hoffmann, Christopher J O'Donnell, Joseph M Massaro, Kiang Liu, Stefan Möhlenkamp, Hongyan Ning, Oscar H Franco, Philip Greenland
Importance: The role of coronary artery calcium (CAC) testing for guiding preventive strategies among women at low cardiovascular disease (CVD) risk based on the American College of Cardiology and American Heart Association CVD prevention guidelines is unclear. Objective: To assess the potential utility of CAC testing for CVD risk estimation and stratification among low-risk women. Design, Setting, and Participants: Women with 10-year atherosclerotic CVD (ASCVD) risk lower than 7...
November 22, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27832125/cluster-individuals-based-on-phenotype-and-determine-the-risk-for-atrial-fibrillation-in-the-prevend-and-framingham-heart-study-populations
#11
Michiel Rienstra, Bastiaan Geelhoed, Xiaoyan Yin, Joylene E Siland, Rob A Vermond, Bart A Mulder, Pim Van Der Harst, Hans L Hillege, Emelia J Benjamin, Isabelle C Van Gelder
BACKGROUND: Risk prediction of atrial fibrillation (AF) is of importance to improve the early diagnosis and treatment of AF. Latent class analysis takes into account the possible existence of classes of individuals each with shared risk factors, and maybe a better method of incorporating the phenotypic heterogeneity underlying AF. METHODS AND FINDINGS: Two prospective community-based cohort studies from Netherlands and United States were used. Prevention of Renal and Vascular End-stage Disease (PREVEND) study, started in 1997, and the Framingham Heart Study (FHS) Offspring cohort started in 1971, both with 10-years follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27832070/pleiotropic-associations-of-allelic-variants-in-a-2q22-region-with-risks-of-major-human-diseases-and-mortality
#12
Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu, Anatoliy I Yashin
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene studies. Genome-wide scan in the Atherosclerosis Risk in Communities (ARIC) Study (N = 9,573) was used to pre-select promising loci. Candidate-gene methods were used to comprehensively analyze associations of novel uncommon variants in Caucasians (minor allele frequency~2...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27831900/aggregate-penetrance-of-genomic-variants-for-actionable-disorders-in-european-and-african-americans
#13
Pradeep Natarajan, Nina B Gold, Alexander G Bick, Heather McLaughlin, Peter Kraft, Heidi L Rehm, Gina M Peloso, James G Wilson, Adolfo Correa, Jonathan G Seidman, Christine E Seidman, Sekar Kathiresan, Robert C Green
In populations that have not been selected for family history of disease, it is unclear how commonly pathogenic variants (PVs) in disease-associated genes for rare Mendelian conditions are found and how often they are associated with clinical features of these conditions. We conducted independent, prospective analyses of participants in two community-based epidemiological studies to test the hypothesis that persons carrying PVs in any of 56 genes that lead to 24 dominantly inherited, actionable conditions are more likely to exhibit the clinical features of the corresponding diseases than those without PVs...
November 9, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27822124/changes-in-coronary-heart-disease-risk-profiles-of-hiv-patients-in-zimbabwe-over-9-months-a-follow-up-study
#14
Danai Tavonga Zhou, Olav Oektedalen, Sandra Shawarira-Bote, Babill Stray-Pedersen
Dyslipidemia, hypertension, inflammation, and coronary heart disease (CHD) are adverse events in human immunodeficiency virus (HIV)-infected patients even if they are receiving antiretroviral therapy (ART). Yet, data on CHD risk induced by HIV or ART in sub-Saharan Africa are limited. The aim of this longitudinal study was to describe changes in CHD risk profiles measured by lipids, inflammatory markers, and Framingham scores among HIV-positive patients previously reported from Harare, Zimbabwe. Patients were grouped into ART-experienced patients (n=147) and ART-naïve patients (n=23) and followed up for 9 months...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27816938/genome-wide-association-study-of-parental-life-span
#15
Toshiko Tanaka, Ambarish Dutta, Luke C Pilling, Luting Xue, Kathryn L Lunetta, Joanne M Murabito, Stefania Bandinelli, Robert Wallace, David Melzer, Luigi Ferrucci
BACKGROUND: Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity. METHODS: A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted. RESULTS: A genome-wide significant association was observed for rs35715456 (log10BF = 6...
November 5, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27815376/impact-of-smoking-on-circulating-cardiac-troponin-i-concentrations-and-cardiovascular-events-in-the-general-population-the-hunt-study
#16
Magnus N Lyngbakken, Julia B Skranes, James A de Lemos, Ståle Nygård, Håvard Dalen, Kristian Hveem, Helge Røsjø, Torbjørn Omland
BACKGROUND: -Both tobacco smoking and circulating cardiac troponin I (cTnI) levels are associated with the risk of acute myocardial infarction (AMI), heart failure (HF) and cardiovascular death. However, whether cardiac troponin I levels differ according to smoking status, or whether smoking modifies the prognostic relationship between cardiac troponin I and outcomes remain unclear. METHODS: -Using data from a large population-based cohort, we assessed the association between smoking and cTnI, and the impact of smoking on the associations between cTnI levels and the incidence of AMI, HF and cardiovascular death...
November 4, 2016: Circulation
https://www.readbyqxmd.com/read/27814369/non-communicable-disease-risk-factors-among-employees-and-their-families-of-a-saudi-university-an-epidemiological-study
#17
Rasmieh Alzeidan, Fatemeh Rabiee, Ahmed Mandil, Ahmad Hersi, Amel Fayed
OBJECTIVES: To assess the prevalence of noncommunicable disease (NCD) risk factors among Saudi university employees and their families; to estimate the cardiovascular risk (CVR) amongst the study population in the following 10years. METHODS: The NCD risk factors prevalence was estimated using a cross-sectional approach for a sample of employees and their families aged ≥ 18 years old, in a Saudi university (Riyadh in Kingdom of Saudi Arabia; KSA). WHO STEPwise standardized tools were used to estimate NCD risk factors and the Framingham Coronary Heart Risk Score calculator was used to calculate the CVR...
2016: PloS One
https://www.readbyqxmd.com/read/27813215/mendelian-randomization-analysis-of-a-time-varying-exposure-for-binary-disease-outcomes-using-functional-data-analysis-methods
#18
Ying Cao, Suja S Rajan, Peng Wei
A Mendelian randomization (MR) analysis is performed to analyze the causal effect of an exposure variable on a disease outcome in observational studies, by using genetic variants that affect the disease outcome only through the exposure variable. This method has recently gained popularity among epidemiologists given the success of genetic association studies. Many exposure variables of interest in epidemiological studies are time varying, for example, body mass index (BMI). Although longitudinal data have been collected in many cohort studies, current MR studies only use one measurement of a time-varying exposure variable, which cannot adequately capture the long-term time-varying information...
December 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27811210/a-novel-protein-glycan-derived-inflammation-biomarker-independently-predicts-cardiovascular-disease-and-modifies-the-association-of-hdl-subclasses-with-mortality
#19
Robert W McGarrah, Jacob P Kelly, Damian M Craig, Carol Haynes, Ryan C Jessee, Kim M Huffman, William E Kraus, Svati H Shah
BACKGROUND: Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of glycoprotein acetylation (GlycA)-a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins-and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL subclasses...
November 3, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27809784/a-comparison-of-time-dependent-cox-regression-pooled-logistic-regression-and-cross-sectional-pooling-with-simulations-and-an-application-to-the-framingham-heart-study
#20
Julius S Ngwa, Howard J Cabral, Debbie M Cheng, Michael J Pencina, David R Gagnon, Michael P LaValley, L Adrienne Cupples
BACKGROUND: Typical survival studies follow individuals to an event and measure explanatory variables for that event, sometimes repeatedly over the course of follow up. The Cox regression model has been used widely in the analyses of time to diagnosis or death from disease. The associations between the survival outcome and time dependent measures may be biased unless they are modeled appropriately. METHODS: In this paper we explore the Time Dependent Cox Regression Model (TDCM), which quantifies the effect of repeated measures of covariates in the analysis of time to event data...
November 3, 2016: BMC Medical Research Methodology
keyword
keyword
109150
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"