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framingham heart study

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https://www.readbyqxmd.com/read/29774558/clinical-outcome-and-comparison-of-three-different-left-ventricular-assist-devices-in-a-high-risk-cohort
#1
Konstantin Zhigalov, Ahmed Mashhour, Marcin Szczechowicz, Sabreen Mkalaluh, Sergei Karagezian, Irakli Gogia, Maxim Isaev, Bakitbek K Kadyraliev, Jerry Easo, Juergen Ennker, Harald C Eichstaedt, Alexander Weymann
We present a comparison between three left ventricular assist devices (LVADs): HeartWare (HVAD) (HeartWare International Inc., Framingham, MA, USA), HeartMate II (HMII) and HeartMate III (HMIII) (Thoratec Corp., Pleasanton, CA, USA). To our knowledge, no study to date has aimed at placing these three devices in juxtaposition. Between June 2007 and June 2017, 108 consecutive patients received HMII, n = 77 (71.3%), HVAD, n = 14 (13%), or HM III, n = 17 (15.7%), for end-stage heart failure. Mean age was 63...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29773573/twenty-year-trends-in-the-american-heart-association-cardiovascular-health-score-and-impact-on-subclinical-and-clinical-cardiovascular-disease-the-framingham-offspring-study
#2
Danielle M Enserro, Ramachandran S Vasan, Vanessa Xanthakis
BACKGROUND: Data on the temporal trends in ideal cardiovascular health (CVH) as well as on their association with subclinical/overt cardiovascular disease (CVD) and death are limited. METHODS AND RESULTS: This study included 3460 participants attending ≥1 of 4 consecutive exams of the Framingham Heart Study (1991-2008, mean age 55.4 years, CVH score ranged 0-14). We created 4 groups describing changes in CVH score between examination cycles 5 and 8, using first and last exams attended (high-high: starting CVH score ≥8, last score of ≥8, referent; high-low: ≥8 start and ≤7 last; low-high: ≤7 start and ≥8 last; and low-low: ≤7 start and ≤7 last) and related them to subclinical CVD cross-sectionally, and incident CVD and death...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29762858/evaluation-of-cardiovascular-risk-profile-a-comparative-analysis-between-cuore-algorithm-and-the-framingham-risk-scores
#3
G La Torre, V Palmeri, L Pagano, G Nati, S Sernia, A Mannocci
OBJECTIVE: Coronary heart diseases (CHD) are the leading cause of premature death and loss of disability adjusted life years in Europe. In order to implement appropriate health interventions as preventive tools, it is necessary to understand the epidemiological stratification of cardiovascular risk and the specific situation of each individual reality. This study investigates the reliability of two algorithms used to assess cardiovascular risk: the Framingham algorithm and the CUORE algorithm...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29759909/the-predictive-value-of-arteriogenic-erectile-dysfunction-for-coronary-artery-disease-in-men
#4
Sherif Salah Azab, Hossam El Din Hosni, Taha A El Far, Nashaat Nabil Ismail, Yasser K El Bakdady, Ahmed F Mohamed
BACKGROUND: Erectile dysfunction (ED) is assumed to be connected with vascular disease caused by endothelial dysfunction, and characterized by the incapability of the smooth muscle cells lining the arterioles to relax, therefore, inhibit vasodilatation. AIM: To assess the predictive value of arteriogenic ED for coronary artery disease in men above the age of 40 years. METHODS: 75 Patients reporting arteriogenic ED and 25 men with normal erectile function were enrolled in the study...
May 11, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29740313/epigenome-wide-association-study-of-soluble-tumor-necrosis-factor-receptor-2-levels-in-the-framingham-heart-study
#5
Michael M Mendelson, Roby Johannes, Chunyu Liu, Tianxiao Huan, Chen Yao, Xiao Miao, Joanne M Murabito, Josée Dupuis, Daniel Levy, Emelia J Benjamin, Honghuang Lin
Background: Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF receptor II (sTNFR2) can modify the inflammatory response of immune cells and is predictive of cardiovascular disease risk. We hypothesize that sTNFR2 is associated with epigenetic modifications of circulating leukocytes, which may relate to the pathophysiology underlying atherogenic risk. Methods: We conducted an epigenome-wide association study of sTNFR2 levels in the Framingham Heart Study Offspring cohort (examination 8; 2005-2008)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29739677/soy-isoflavones-improve-cardiovascular-disease-risk-markers-in-women-during-the-early-menopause
#6
T Sathyapalan, M Aye, A S Rigby, N J Thatcher, S R Dargham, E S Kilpatrick, S L Atkin
BACKGROUND: Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers. METHODS: The expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months...
April 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29737513/development-and-validation-of-a-difficulty-score-to-predict-intraoperative-complications-during-laparoscopic-liver-resection
#7
M C Halls, G Berardi, F Cipriani, L Barkhatov, P Lainas, S Harris, M D'Hondt, F Rotellar, I Dagher, L Aldrighetti, R I Troisi, B Edwin, M Abu Hilal
BACKGROUND: Previous studies have demonstrated that patient, surgical, tumour and operative variables affect the complexity of laparoscopic liver resections. However, current difficulty scoring systems address only tumour factors. The aim of this study was to develop and validate a predictive model for the risk of intraoperative complications during laparoscopic liver resections. METHODS: The prospectively maintained databases of seven European tertiary referral liver centres were compiled...
May 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29734516/dermal-capillary-rarefaction-as-a-marker-of-microvascular-damage-in-patients-with-rheumatoid-arthritis-association-with-inflammation-and-disorders-of-the-macrocirculation
#8
Panagiota Anyfanti, Eugenia Gkaliagkousi, Areti Triantafyllou, Xenophon Zabulis, Panagiotis Dolgyras, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Capillary rarefaction is observed in various cardiovascular diseases, yet it remains understudied in RA, a chronic inflammatory disease accompanied by excess cardiovascular risk. We quantified capillary density in RA patients and explored potential associations with macrocirculatory disorders, inflammation and cardiovascular risk. METHODS: Dermal capillary density was assessed with nailfold capillaroscopy in RA and non-RA individuals, using specifically designed semiautomated software...
May 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29728014/ceramide-remodeling-and-risk-of-cardiovascular-events-and-mortality
#9
Linda R Peterson, Vanessa Xanthakis, Meredith S Duncan, Stefan Gross, Nele Friedrich, Henry Völzke, Stephan B Felix, Hui Jiang, Rohini Sidhu, Matthias Nauck, Xuntian Jiang, Daniel S Ory, Marcus Dörr, Ramachandran S Vasan, Jean E Schaffer
BACKGROUND: Recent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl chain lengths and the risk of coronary heart disease (CHD) and mortality in community-based samples. METHODS AND RESULTS: We developed a liquid chromatography/mass spectrometry assay to quantify plasma C24:0, C22:0, and C16:0 ceramides and ratios of these very-long-chain/long-chain ceramides in 2642 FHS (Framingham Heart Study) participants and in 3134 SHIP (Study of Health in Pomerania) participants...
May 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29727376/cardiovascular-disease-risk-among-older-immigrants-in-the-united-states-a-comparison-of-risk-measures
#10
Tina R Sadarangani, Deborah Chyun, Chau Trinh-Shevrin, Gary Yu, Christine Kovner
BACKGROUND: In the United States, 16 million immigrants are 50 years and older, but little is known about their cardiometabolic health and how to best assess their cardiovascular disease (CVD) risk. Aging immigrants may therefore not be benefitting from advances in CVD prevention. OBJECTIVE: In this study, we estimate and compare CVD risk in a nationally representative sample of aging immigrants using 3 different measures. METHODS: This was a cross-sectional analysis using National Health and Nutrition Examination Survey data...
April 27, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29710704/assessment-of-the-mid-life-demographic-and-lifestyle-risk-factors-of-dementia-using-data-from-the-framingham-heart-study-offspring-cohort
#11
Jinlei Li, Matthew Ogrodnik, Vijaya B Kolachalama, Honghuang Lin, Rhoda Au
BACKGROUND: Dementia is the leading cause of dependence and disability in the elderly population worldwide. However, currently there is no effective medication for dementia treatment. Therefore, identifying life-related risk factors including some that are modifiable may provide important strategies for reducing risk of dementia. OBJECTIVE: This study aims to highlight associations between easily obtainable life risk factors in mid-life and dementia in later adulthood...
April 27, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29706397/cardiovascular-risk-goes-up-as-your-mood-goes-down-interaction-of-depression-and-socioeconomic-status-in-determination-of-cardiovascular-risk-in-the-constances-cohort
#12
Emmanuel Wiernik, Pierre Meneton, Jean-Philippe Empana, Jack Siemiatycki, Nicolas Hoertel, Hélène Vulser, Hermann Nabi, Frédéric Limosin, Sébastien Czernichow, Marcel Goldberg, Anna Ozguler, Marie Zins, Cédric Lemogne
BACKGROUND: Recent evidence suggests that the association of psychological variables with the risk of coronary heart disease (CHD) might depend upon socioeconomic status (SES). However, it is unclear whether the association between depressive symptoms and CHD risk might differ according to three SES indicators (education, occupational status and household monthly income). METHODS: Among 34,836 working participants of the French CONSTANCES cohort (16,221 men, mean age [SD]: 44...
July 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29699974/lifetime-risk-of-atrial-fibrillation-according-to-optimal-borderline-or-elevated-levels-of-risk-factors-cohort-study-based-on-longitudinal-data-from-the-framingham-heart-study
#13
Laila Staerk, Biqi Wang, Sarah R Preis, Martin G Larson, Steven A Lubitz, Patrick T Ellinor, David D McManus, Darae Ko, Lu-Chen Weng, Kathryn L Lunetta, Lars Frost, Emelia J Benjamin, Ludovic Trinquart
OBJECTIVE: To examine the association between risk factor burdens-categorized as optimal, borderline, or elevated-and the lifetime risk of atrial fibrillation. DESIGN: Community based cohort study. SETTING: Longitudinal data from the Framingham Heart Study. PARTICIPANTS: Individuals free of atrial fibrillation at index ages 55, 65, and 75 years were assessed. Smoking, alcohol consumption, body mass index, blood pressure, diabetes, and history of heart failure or myocardial infarction were assessed as being optimal (that is, all risk factors were optimal), borderline (presence of borderline risk factors and absence of any elevated risk factor), or elevated (presence of at least one elevated risk factor) at index age...
April 26, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29688268/a-longitudinal-study-of-trunk-muscle-properties-and-severity-of-thoracic-kyphosis-in-women-and-men-the-framingham-study
#14
Amanda L Lorbergs, Brett T Allaire, Laiji Yang, Douglas P Kiel, L Adrienne Cupples, Mohamed Jarraya, Ali Guermazi, Thomas G Travison, Mary L Bouxsein, Dennis E Anderson, Elizabeth J Samelson
Background: Cross-sectional studies suggest that trunk muscle morphology in the lumbar spine is an important determinant of kyphosis severity in older adults. The contribution of age-related changes in muscle morphology in the thoracic and lumbar spine to progression of kyphosis is not known. Our objective was to determine cross-sectional and longitudinal associations of thoracic and lumbar muscle size and density with kyphosis. Methods: Participants were 1,087 women and men (mean age 61y) of the Framingham Heart Study who underwent baseline and follow-up quantitative computed tomography (QCT) scanning 6y apart...
April 24, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29686252/micro-rnas-from-dna-viruses-are-found-widely-in-plasma-in-a-large-observational-human-population
#15
Milka Koupenova, Eric Mick, Heather A Corkrey, Tianxiao Huan, Lauren Clancy, Ravi Shah, Emelia J Benjamin, Daniel Levy, Evelyn A Kurt-Jones, Kahraman Tanriverdi, Jane E Freedman
Viral infections associate with disease risk and select families of viruses encode miRNAs that control an efficient viral cycle. The association of viral miRNA expression with disease in a large human population has not been previously explored. We sequenced plasma RNA from 40 participants of the Framingham Heart Study (FHS, Offspring Cohort, Visit 8) and identified 3 viral miRNAs from 3 different human Herpesviridae. These miRNAs were mostly related to viral latency and have not been previously detected in human plasma...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29676517/impact-of-changes-in-inflammation-on-estimated-10-year-cardiovascular-risk-in-rheumatoid-arthritis
#16
Zhi Yu, Nicole Yang, Brendan M Everett, Michelle Frits, Christine Iannaccone, Jonathan Coblyn, Michael Weinblatt, Nancy Shadick, Daniel H Solomon, Katherine P Liao
BACKGROUND: Validated cardiovascular (CV) risk estimates were developed in populations with relatively stable inflammatory levels. In rheumatoid arthritis (RA), patients routinely experience significant changes in inflammation. We tested whether changes in inflammation impact estimated CV risk as measured using validated population-based risk calculators. METHODS: We studied participants in a prospective RA cohort. We included participants who experienced a decrease (CRP decrease group) or increase (CRP increase group) of ≥10mg/L in C-reactive protein (CRP) at 2 consecutive time points, 1 year apart...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#17
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29669105/are-trends-in-dementia-incidence-associated-with-compression-in-morbidity-evidence-from-the-framingham-heart-study
#18
Carole Dufouil, Alexa Beiser, Geneviève Chêne, Sudha Seshadri
Objectives: Several epidemiological studies suggest declining trends in dementia over the last three decades with both decreasing age-specific prevalence and incidence. There is limited data on whether this delayed clinical onset is accompanied by a shorter postdiagnosis survival. Methods: A total of 5,205 participants from the Framingham Original and Offspring cohorts were studied. Four epochs were considered from 1977-1984 to 2004-2008. Gender and education adjusted 5-year mortality risks were estimated using delayed entry Cox models with the earliest epoch as reference category...
April 16, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#19
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657043/endothelial-dysfunction-abnormal-vascular-structure-and-lower-urinary-tract-symptoms-in-men-and-women
#20
Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Yumiko Iwamoto, Nozomu Oda, Shinji Kishimoto, Haruki Hashimoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Eisuke Hida, Chikara Goto, Yoshiki Aibara, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yoshitaka Kuwahara, Akio Matsubara, Yukihito Higashi
BACKGROUND: Lower urinary tract symptoms (LUTS) is not only common symptoms in elderly men and women but also risk of future cardiovascular events. The purpose of this study was to evaluate the relationships of vascular function and structure with LUTS in men and women. METHODS: We investigated flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) as vascular function, brachial-ankle pulse wave velocity (baPWV) as vascular structure, and LUTS assessed by International Prostate Symptom Score (IPSS) in 287 men and 147 women...
June 15, 2018: International Journal of Cardiology
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