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neo-adjuvant chemotherapy

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https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#1
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27903675/a-pam50-based-chemo-endocrine-score-for-hormone-receptor-positive-breast-cancer-with-an-intermediate-risk-of-relapse
#2
Aleix Prat, Ana Lluch, Arran K Turnbull, Anita K Dunbier, Lourdes Calvo, Joan Albanell, Juan de la Haba-Rodríguez, Angels Arcusa, Ignacio Chacón, Pedro Sánchez-Rovira, Arrate Plazaola, Montse Muñoz, Laia Paré, Joel S Parker, Nuria Ribelles, Begona Jimenez, Abdul Aziz Bin Aiderus, Rosalía Caballero, Barbara Adamo, Mitch Dowsett, Eva M Carrasco, Miguel Martín, J Michael Dixon, Charles M Perou, Emilio Alba
PURPOSE: Hormone receptor-positive (HR+) breast cancer is clinically and biologically heterogeneous and subgroups with different prognostic and treatment sensitivities need to be identified. EXPERIMENTAL DESIGN: Research-based PAM50 subtyping and expression of additional genes was performed on 63 patients with HR+/HER2- disease randomized to neoadjuvant multi-agent chemotherapy versus endocrine therapy in a phase II trial. The biology associated with treatment response was used to derive a PAM50-based Chemo-Endocrine Score (CES)...
November 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27896952/muscle-strength-in-breast-cancer-patients-receiving-different-treatment-regimes
#3
Oliver Klassen, Martina E Schmidt, Cornelia M Ulrich, Andreas Schneeweiss, Karin Potthoff, Karen Steindorf, Joachim Wiskemann
BACKGROUND: Muscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals. METHODS: Breast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0-III and aged 54...
November 28, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27893634/comparison-of-different-acellular-dermal-matrix-adm-in-breast-reconstruction-the-50-50-study
#4
Troy A Pittman, Kenneth L Fan, Andrew Knapp, Shelby Frantz, Scott L Spear
BACKGROUND: Acellular Dermal Matrix (ADM) has enjoyed extensive use in primary and secondary alloplastic breast aesthetic and reconstructive surgery. The objective of this study is to examine clinical outcomes between available ADM: DermACELL(LifeNet Health, Virginia Beach, VA) and AlloDerm RTU (LifeCell, Branchburg, New Jersey). METHODS: A retrospective chart review was performed on 58 consecutive patients (100 breasts) reconstructed with either DermACELL(n=30 patients; 50 breasts) or AlloDerm RTU (n=28 patients; 50 breasts)...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27869361/clinical-outcomes-according-to-molecular-subtypes-in-stage-ii-iii-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-followed-by-surgery-and-radiotherapy
#5
Hakyoung Kim, Won Park, Seung Jae Huh, Doo Ho Choi, Jae Myoung Noh, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Eun Yoon Cho
AIM: We evaluated the tumor response and clinical outcomes according to molecular subtypes in stage II-III breast cancer patients who received neo-adjuvant chemotherapy (NAC) followed by surgery and radiotherapy. METHODS: We retrospectively analyzed 329 patients with clinical stage II-III breast cancer who received NAC followed by surgery and radiotherapy. Luminal A and B, HER2-enriched and triple-negative subgroups were identified. RESULTS: The overall pathologic complete response (pCR) rate after NAC was 20...
November 21, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27866094/-neo-adjuvant-treatment-in-localised-soft-tissue-sarcoma-the-unsolved-affair
#6
REVIEW
Maristella Saponara, Silvia Stacchiotti, Paolo G Casali, Alessandro Gronchi
Soft tissue sarcomas (STS) are rare and heterogeneous tumours. A correct definition of STS is imperative from the very beginning of disease management, to guide the diagnostic and imaging work-up, and help to establish the prognosis on which the therapeutic strategy will be based. Over the last few years, many efforts have been made to identify characteristics that could predict disease behaviour and to enrich the therapeutic armamentarium against the advanced disease, that is still characterised by poor prognosis...
November 17, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27846931/-ccafu-french-national-guidelines-2016-2018-on-retroperitoneal-sarcoma
#7
T Murez, A Fléchon, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean, X Durand
INTRODUCTION: The purpose of this article was established by the external genitalia group CCAFU recommandations for diagnosis, treatment and monitoring of retroperitoneal sarcomas, intended for urologists. MATERIAL AND METHODS: The multidisciplinary working group has updated the 2013 guidelines, based on an exhaustive review of the literature on PubMed, valued references, level of evidence, to assign grades of recommendation. RESULTS: From a clinical suspicion evoking a RPS, computed tomography thoraco abdominal and pelvic is the gold standard...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27845242/neo-adjuvant-chemotherapy-with-cisplatin-induces-low-expression-of-nmda-receptors-and-postoperative-cognitive-impairment
#8
Jing Cheng, Xiaoqing Liu, Longhui Cao, Tianhua Zhang, Huiting Li, Wenqian Lin
Whether Neo-adjuvant chemotherapy can affect patients' postoperative brain function is not clear. In this study, we investigated the effect of preoperative cisplatin treatment on postoperative cognitive function and its possible mechanism in rats. Moreover, we also tested whether the NMDAR inhibitor memantine could attenuate cisplatin-induced alterations. 12-month-oldSprague-Dawley rats randomly received an intraperitoneal injection of either cisplatin once a week at a dose of 3mg/kg for three consecutive weeks or an equivalent volume of normal saline...
November 11, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27835573/the-associations-between-mast-cell-infiltration-clinical-features-and-molecular-types-of-invasive-breast-cancer
#9
Jianfeng Sang, Dandan Yi, Xiaoqiao Tang, Yifen Zhang, Tao Huang
Associations between mast cell infiltration and the clinical features and known molecular profile of breast cancer remain unclear. The distribution difference of mast cell was evaluated, in 219 patients with no special type of invasive carcinoma, using sorts of age, max diameter of cancer, histological type, lymph node metastasis as well as the expressions of estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor 2 (HER-2) and nuclear protein Ki67. The mast cell density (MCD) in patients younger than 50 years old was significantly higher than that in patients with age ≥ 50...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27818590/preoperative-therapy-in-locally-advanced-esophageal-cancer
#10
REVIEW
Pankaj Kumar Garg, Jyoti Sharma, Ashish Jakhetiya, Aakanksha Goel, Manish Kumar Gaur
Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer (T2 or greater or node positive); however, a high rate of disease recurrence (systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment (preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27798913/influence-of-organ-invasion-in-clinical-outcomes-for-locally-advanced-rectal-cancer
#11
Francesca DE Felice, Daniela Musio, Ilaria Benevento, Annalisa Magnante, Nadia Bulzonetti, Caiazzo Rossella, Vincenzo Tombolini
AIM: To evaluate whether patients with external sphincter invasion have a better prognosis than patients with invasion of other organs. PATIENTS AND METHODS: Patients with cT4b adenocarcinoma of the rectum were treated with a tri-modality approach, including neo-adjuvant chemoradiotherapy (CRT), surgery and adjuvant chemotherapy. Patients with external sphincter invasion were classified as cT4b1, whereas patients with invasion of other organs as cT4b2. Survival curves were compared for cT4b sub-stage...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27785427/adjuvant-radiotherapy-for-pathological-high-risk-muscle-invasive-bladder-cancer-time-to-reconsider
#12
REVIEW
Paul Sargos, Brian C Baumann, Libni J Eapen, Amit Bahl, Vedang Murthy, Guilhem Roubaud, Mathieu Orré, Jason A Efstathiou, Shahrokh Shariat, Stephane Larré, Pierre Richaud, John P Christodouleas
Radical cystectomy with extended pelvic lymph-node dissection, associated with neo-adjuvant chemotherapy, remains the standard of care for advanced, non-metastatic muscle-invasive bladder cancer (MIBC). Loco-regional control is a key factor in the outcome of patients since it is related to overall survival (OS), disease-free survival (DFS) and cause-specific survival. The risk of loco-regional recurrence (LRR) is correlated to pathological factors as well as the extent of the lymphadenectomy. In addition, neither pre- nor post-operative chemotherapy have shown a clear impact on LRR-free survival...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27769634/upper-outer-boundaries-of-the-axillary-dissection-result-of-the-sentibras-protocol-multicentric-protocol-using-axillary-reverse-mapping-in-breast-cancer-patients-requiring-axillary-dissection
#13
C Nos, K B Clough, P Bonnier, S Lasry, G Le Bouedec, B Flipo, J-M Classe, M-C Missana, V Doridot, S Giard, H Charitansky, A Charles-Nelson, A-S Bats, C Ngo
BACKGROUND: Two thirds of node-positive breast cancer patients have limited pN1 disease and could benefit from a less extensive axillary lymph node dissection (ALND). METHODS: 172 breast cancers patients requiring an ALND were prospectively enrolled in the Sentibras Protocol of Axillary Reverse Mapping (ARM). Radioisotope was injected in the ipsilateral hand the day before surgery. ALND was standard. Removed lymph nodes were classified into non radioactive nodes and radioactive nodes (ARM nodes)...
August 26, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27756884/early2-factor-e2f-deregulation-is-a-prognostic-and-predictive-biomarker-in-lung-adenocarcinoma
#14
Lu Chen, Courtney A Kurtyka, Eric A Welsh, Jason I Rivera, Brienne E Engel, Teresita Muñoz-Antonia, Sean J Yoder, Steven A Eschrich, Ben C Creelan, Alberto A Chiappori, Jhanelle E Gray, Jose Luis Ramirez, Rafael Rosell, Matthew B Schabath, Eric B Haura, Dung-Tsa Chen, W Douglas Cress
Clinicians routinely prescribe adjuvant chemotherapy (ACT) for resected non-small cell lung cancer patients. However, ACT only improves five-year disease-free survival in stage I-III non-small cell lung cancer by 5-15%, with most patients deriving no benefit. Herein, deregulation of the E2F pathway was explored as a biomarker in lung adenocarcinoma patients. An E2F pathway scoring system, based on 74 E2F-regulated genes, was trained for RNA from two platforms: fresh-frozen (FF) or formalin-fixed paraffin-embedded (FFPE) tissues...
October 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27756583/final-results-of-the-randomized-phase-ii-norcap-ca223-trial-comparing-first-line-all-oral-versus-taxane-based-chemotherapy-for%C3%A2-her2-negative-metastatic-breast-cancer
#15
Saverio Cinieri, Arlene Chan, Kadri Altundag, An Vandebroek, Nicole Tubiana-Mathieu, Agusti Barnadas, Patricia Dodyk, Silvia Lazzarelli, Michiel Botha, Daniel Rauch, Gustavo Villanova, Ugur Coskun
BACKGROUND: The purpose of this study was to evaluate the efficacy of 3 first-line chemotherapy combination regimens for HER2-negative metastatic breast cancer (mBC). PATIENTS AND METHODS: In this open-label, 3-arm, randomized phase II trial, patients were randomized to all-oral NORCAP (vinorelbine/capecitabine), GEMPAC (gemcitabine/paclitaxel), or GEMDOC (gemcitabine/docetaxel) as first-line chemotherapy for HER2-negative mBC. Stratification factors were center, previous (neo)adjuvant anthracycline, and age...
June 25, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27740855/neutrophil-to-lymphocyte-ratio-nlr-and-derived-neutrophil-to-lymphocyte-ratio-d-nlr-predict-non-responders-and-postoperative-complications-in-patients-undergoing-radical-surgery-after-neo-adjuvant-radio-chemotherapy-for-rectal-adenocarcinoma
#16
Damiano Caputo, Marco Caricato, Alessandro Coppola, Vincenzo La Vaccara, Michele Fiore, Roberto Coppola
In order to evaluate neutrophil-to-lymphocyte ratio (NLR) and derived neutrophil-to-lymphocyte ratio (d-NLR) in predicting response and complications in rectal cancer patients who underwent surgery after neo-adjuvant radio-chemotherapy, 87 patients were evaluated. Cutoffs before and after radio-chemotherapy were respectively 2.8 and 3.8 for NLR, and 1.4 and 2.3 for d-NLR. They were analyzed in relation to clinical and pathological outcomes. Patients with preoperative NLR and d-NLR higher than cutoffs had significantly higher rates of tumor regression grade response (TRG ≥ 4) and postoperative complications...
October 14, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27729748/defining-response-to-radiotherapy-in-rectal-cancer-using-magnetic-resonance-imaging-and-histopathological-scales
#17
Muhammed R S Siddiqui, Jemma Bhoday, Nicholas J Battersby, Manish Chand, Nicholas P West, Al-Mutaz Abulafi, Paris P Tekkis, Gina Brown
AIM: To define good and poor regression using pathology and magnetic resonance imaging (MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer. METHODS: A systematic review was performed on all studies up to December 2015, without language restriction, that were identified from MEDLINE, Cochrane Controlled Trials Register (1960-2015), and EMBASE (1991-2015). Searches were performed of article bibliographies and conference abstracts. MeSH and text words used included "tumour regression", "mrTRG", "poor response" and "colorectal cancers"...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27697137/cancer-of-the-upper-rectum
#18
Peter Bondeven
Rectal cancer constitutes one-third of all colorectal cancers, and the incidence in Denmark increasing. In 2012, 1.400 cases were registered, and of these 38% were located in the upper rectum. There have been several key advances in the optimal management of rectal cancer during the past decades, primarily by standardisation and improvement of the surgical procedure. There is now general agreement that the optimal surgical treatment involves the concept of total mesorectal excision and that a resection with tumour-free margins is crucial...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27692894/mrna-expression-profiles-of-colorectal-liver-metastases-as-a-novel-biomarker-for-early-recurrence-after-partial-hepatectomy
#19
E P van der Stok, M Smid, A M Sieuwerts, P B Vermeulen, S Sleijfer, N Ayez, D J Grünhagen, J W M Martens, C Verhoef
BACKGROUND: Identification of specific risk groups for recurrence after surgery for isolated colorectal liver metastases (CRLM) remains challenging due to the heterogeneity of the disease. Classical clinicopathologic parameters have limited prognostic value. The aim of this study was to identify a gene expression signature measured in CRLM discriminating early from late recurrence after partial hepatectomy. METHODS: CRLM from two patient groups were collected: I) with recurrent disease ≤12 months after surgery (N = 33), and II) without recurrences and disease free for ≥36 months (N = 30)...
September 20, 2016: Molecular Oncology
https://www.readbyqxmd.com/read/27663951/radiotherapy-induced-dermatitis-is-a-strong-predictor-for-late-fibrosis-in-head-and-neck-cancer-the-development-of-a-predictive-model-for-late-fibrosis
#20
Daan Nevens, Fréderic Duprez, Jean Francois Daisne, Annouschka Laenen, Wilfried De Neve, Sandra Nuyts
PURPOSE: To determine if the severity of radiodermatitis at the end of radio(chemo)therapy (R(C)T) for head and neck cancer (HNC) is a predictive factor for late fibrosis of the neck and to find a model to predict neck fibrosis grade⩾2 (fibrosis RTOG2-4) at 6months following R(C)T for HNC. MATERIAL/METHODS: 161 patients were prospectively included. We correlated radiodermatitis at the end of RCT, age, sex, T/N stage, tumor site, concomitant chemotherapy, upfront neck dissection, neo-adjuvant chemotherapy, accelerated RT, smoking, alcohol consumption, HPV status and the dose prescribed to the elective neck with fibrosis RTOG2-4 6months after the end of treatment...
September 20, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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