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neo-adjuvant chemotherapy

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https://www.readbyqxmd.com/read/29773838/impact-of-timing-of-trastuzumab-initiation-on-long-term-outcome-of-patients-with-early-stage-her2-positive-breast-cancer-the-one-thousand-her2-patients-project
#1
Giuseppe Gullo, Naomi Walsh, David Fennelly, Reetesh Bose, Janice Walshe, Dimitrios Tryfonopoulos, Kate O'Mahony, Lisa Hammond, Nuno Silva, Deirdre McDonnell, Josephine Ballot, Cecily Quinn, Enda W McDermott, Denis Evoy, Ruth Prichard, James Geraghty, John Amstrong, John Crown
BACKGROUND: The optimal timing of (neo)adjuvant trastuzumab initiation with respect to chemotherapy and surgery remains undefined. METHODS: Retrospective analysis of a large institutional database of HER2-positive patients who received anti-HER2 therapy. We included all Stage I to III patients treated with trastuzumab with a minimum follow up of 3 years. The date of first breast biopsy was recorded as initial diagnosis. RESULTS: A total of 506 patients [adjuvant: 386 (76%)-neo-adjuvant: 120 (24%)] were included...
May 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29753611/neo-adjuvant-platinum-based-chemotherapy-followed-by-chemoradiation-and-radical-surgery-in-locally-advanced-cervical-cancer-lacc-patients-a-phase-ii-study
#2
Gabriella Ferrandina, Eleonora Palluzzi, Valerio Gallotta, Maria Antonietta Gambacorta, Rosa Autorino, Luigi Carlo Turco, Gabriella Macchia, Francesco Cosentino, Benedetta Gui, Maria Vittoria Mattoli, Graziana Ronzino, Vincenzo Valentini, Giovanni Scambia
PURPOSE: The aim of this Phase II, non-randomized study was to assess activity and safety of neoadjuvant chemotherapy (NACT) before chemoradiation (CT/RT) followed by radical surgery (RS) in locally advanced cervical cancer (LACC) patients. METHODS AND MATERIALS: The primary end point was rate of pathologic complete response (pCR). FIGO Stage IB2-IVA patients were administered NACT chemotherapy (paclitaxel 80 mg/m2 , carboplatin AUC 2), for 6 weeks, followed by Intensity Modulated Radiotherapy plus simultaneous boost (total dose of 50...
May 3, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29747270/-prognostic-analysis-of-stage-%C3%A2-b2-and%C3%A2-a2-cervical-squamous-cancer-without-high-risk-factors-treated-with-neo-adjuvant-chemotherapy-and-radical-hysterectomy
#3
P P Li, B Li, Y T Wang, S H Liu, Y N Zhang, R Zhang, P Bai, X G Li, L Y Wu
Objective: To analyze the prognosis of Ⅰb2 and Ⅱa2 cervical squamous cancer without high risk factors treated with neo-adjuvant chemotherapy (NACT) and radical hysterectomy. Methods: This retrospective study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ b2 and Ⅱ a2 cervical squamous cancer without high risk factors who underwent platinum-based NACT followed by radical surgery from January 2008 to January 2015. The responses of NACT were observed and compared in their effect on postoperative pathologic risk factors...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29737474/incidence-and-risk-factors-for-congestive-heart-failure-in-patients-with-early-breast-cancer-who-received-anthracycline-and-or-trastuzumab-a-big-data-analysis-of-the-korean-health-insurance-review-and-assessment-service-database
#4
Jung Yoon Choi, Eun Young Cho, Yoon Ji Choi, Jeong Hyeon Lee, Seung Pil Jung, Kyu Ran Cho, Chul Yong Kim, Yeul Hong Kim, Kyong Hwa Park
PURPOSE: We aimed to analyze the incidence, time to occurrence, and congestive heart failure (CHF) risk factors for early breast cancer patients treated with anthracycline (AC)-based chemotherapy and/or trastuzumab (T) therapy in Korea. METHODS: We included female patients > 19 years old from the Health Insurance Review and Assessment Service database who had no prior CHF history and had been diagnosed with early breast cancer between January 2007 and October 2016...
May 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29722200/emergency-department-presentations-in-early-stage-breast-cancer-patients-receiving-adjuvant-and-neoadjuvant-chemotherapy
#5
Monica Tang, Patrick Horsley, Craig R Lewis
(Neo)adjuvant chemotherapy for early stage breast cancer is associated with side-effects, resulting in increased emergency department (ED) presentations. Treatment-related toxicity can affect quality of life, compromise chemotherapy delivery and treatment outcomes, and increase healthcare use. We performed a retrospective study of ED presentations in patients receiving curative chemotherapy for early breast cancer to identify factors contributing to ED presentations. Of 102 patients, 39 (38%) presented to ED within 30 days of chemotherapy, resulting in 63 ED presentations in total...
May 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29721485/practical-consensus-recommendations-for-neo-adjuvant-chemotherapy-in-triple-negative-breast-cancer
#6
G S Bhattacharyya, M Walia, M Nandi, A Murli, S Salim, S Rajpurohit, S Shinde, S Aggarwal, P M Parikh
This manuscript provides a practical and easy to use consensus recommendation to community oncologists on how to use neoadjuvant chemotherapy in triple negative breast cancer patients.
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29719622/glucose-transporter-1-expression-as-a-marker-of-prognosis-in-oesophageal-adenocarcinoma
#7
Jaine K Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J Peters, Nathan B Reid, Veronica J Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid, Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G Coleman, Rebecca C Fitzgerald, Richard D Kennedy, Richard C Turkington
Background: The current TNM staging system for oesophageal adenocarcinoma (OAC) has limited ability to stratify patients and inform clinical management following neo-adjuvant chemotherapy and surgery. Results: Functional genomic analysis of the gene expression data using Gene Set Enrichment Analysis (GSEA) identified GLUT1 as putative prognostic marker in OAC.In the discovery cohort GLUT1 positivity was observed in 114 patients (80.9%) and was associated with poor overall survival (HR 2...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718793/gonadotropin-releasing-hormone-agonists-during-chemotherapy-for-preservation-of-ovarian-function-and-fertility-in-premenopausal-patients-with-early-breast-cancer-a-systematic-review-and-meta-analysis-of-individual-patient-level-data
#8
Matteo Lambertini, Halle C F Moore, Robert C F Leonard, Sibylle Loibl, Pamela Munster, Marco Bruzzone, Luca Boni, Joseph M Unger, Richard A Anderson, Keyur Mehta, Susan Minton, Francesca Poggio, Kathy S Albain, Douglas J A Adamson, Bernd Gerber, Amy Cripps, Gianfilippo Bertelli, Sabine Seiler, Marcello Ceppi, Ann H Partridge, Lucia Del Mastro
Purpose The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient-level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer. Methods The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29706425/outcome-of-neoadjuvant-chemotherapy-in-locally-advanced-borderline-resectable-gallbladder-cancer-the-need-to-define-indications
#9
Vikram A Chaudhari, Vikas Ostwal, Shraddha Patkar, Arvind Sahu, Anup Toshniwal, Anant Ramaswamy, Nitin S Shetty, Shailesh V Shrikhande, Mahesh Goel
BACKGROUND: Studies evaluating neo-adjuvant chemotherapy (NACT) exclusively in gallbladder cancer (GBC) are few and there are no randomized trials on the subject. Locally advanced GBC and indications for NACT in GBC are not yet clearly defined. METHODS: We analysed 160 consecutive GBC patients who received NACT based on clinico-radiologic criteria suggesting high-risk disease (TMH Criteria) from January 2010 to February 2016. RESULTS: On initial assessment, 140 (87...
April 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29687533/squamous-differentiation-in-breast-carcinoma-following-neo-adjuvant-chemotherapy-therapy-effect-vs-tumor-heterogeneity
#10
Pallavi A Patil, Kamaljeet Singh, Cherie Paquette, M Ruhul Quddus
No abstract text is available yet for this article.
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29674444/adjuvant-chemotherapy-seemed-not-to-have-survival-benefit-in-rectal-cancer-patients-with-yptis-2n0-after-preoperative-radiotherapy-and-surgery-from-a-population-based-propensity-score-analysis
#11
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai
BACKGROUND: Adjuvant chemotherapy is currently offered routinely, as standard, after radical resection for patients with rectal cancer receiving neo-adjuvant chemoradiation. However, the efficacy of adjuvant chemotherapy in patients with ypTis-2N0M0 has not been documented to the same extent, and the survival benefit remained controversial. The purpose of this work was to determine the role of chemotherapy in patients with ypTis-2N0M0 classification. MATERIALS AND METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results database ( n  = 4,217)...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29651385/clinicopathological-predictors-of-long-term-benefit-in-breast-cancer-treated-with-neoadjuvant-chemotherapy
#12
Marco Galvez, Carlos A Castaneda, Joselyn Sanchez, Miluska Castillo, Lia Pamela Rebaza, Gabriela Calderon, Miguel De La Cruz, Jose Manuel Cotrina, Julio Abugattas, Jorge Dunstan, Henry Guerra, Omar Mejia, Henry L Gomez
AIM: To investigate the survival impact of clinicopathological factors, including pathological complete response (pCR) and tumor-infiltrating lymphocytes (sTIL) levels according to subtypes, in breast cancer (BC) patients who received neo-adjuvant chemotherapy (NAC). METHODS: We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. sTIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preNAC core biopsy...
April 10, 2018: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29650829/-a-case-of-stage-iv-gastric-cancer-which-showed-pathological-complete-response-after-neo-adjuvant-chemotherapy
#13
Eiichiro Nakao, Rie Ozawa, Mamiko Takii, Nobuaki Kaibe, Yasunori Kurahashi, Tsutomu Oshima, Hirotaka Niwa, Shojiro Kikuchi, Mitsuru Sasako, Hisashi Shinohara
We report a case of Stage IV gastric cancer showing pathological complete response(pCR)after neo-adjuvant chemotherapy( NAC)using S-1 and oxaliplatin(SOX).A woman 73-year-old was diagnosed as harming type 3 Stage IV gastric cancer with para-aortic lymph node(PAN)metastasis.She underwent 4 courses of NAC with SOX regimen.After the treatment, both the primary tumor and the metastatic PAN decreased in size remarkably.She underwent distal gastrectomy with D2 plus PAN dissection with curative intent.Pathological diagnosis revealed complete disappearance of cancer cells in both the primary lesion of the stomach and all dissected lymph nodes, confirming pCR...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29630153/successful-management-of-congenital-infantile-fibrosarcoma-presenting-as-large-non-healing-buttock-ulceration
#14
Madeleine G Sowash, Karen Itumeleng Mosojane, Alan R Anderson, Carrie L Kovari, Victoria L Williams
A two-year-old boy presented with a large, non-healing ulceration on his left buttock, which was originally noted as a brown patch present at birth. Punch skin biopsy was performed and histopathology revealed an atypical, pleomorphic, spindled proliferation in whorled fascicles replacing the dermis and trapping fat in the subcutis, consistent with a diagnosis of congenital/infantile fibrosarcoma. No evidence of metastatic spread was seen on imaging. The tumor was initially deemed unresectable owing to extent of local invasion...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29625257/5-year-overall-survival-after-early-breast-cancer-diagnosed-during-pregnancy-a-retrospective-case-control-multicentre-french-study
#15
A Ploquin, B Pistilli, E Tresch, J S Frenel, F Lerebours, A Lesur, C Loustalot, T Bachelot, M Provansal, J M Ferrero, F Coussy, M Debled, P Kerbrat, A Vinceneux, D Allouache, F Morvan, F Dalenc, S Guiu, R Rouzier, L Vanlemmens
BACKGROUND: Breast cancer diagnosed during pregnancy (BCP) is rare, but the prevalence is expected to rise. Long-term follow-up data regarding this clinically challenging condition are scarce. The main objective of this multicentre case-control French study was to compare the survival between pregnant patients and matched controls. METHODS: Patients from 27 centres diagnosed between 2000 and 2009 with histologically proven invasive breast cancer occurring during pregnancy were retrospectively included...
April 3, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29615063/prediction-of-treatment-responses-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-by-analysis-of-immune-checkpoint-protein-expression
#16
Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: "Avoiding immune destruction" has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression mechanism that allows cancer cells to escape host immunity. The present study investigated how the expressions of these immune checkpoint proteins affected responses to neo-adjuvant chemotherapy (NAC) in breast cancer. METHODS: A total of 177 patients with resectable early-stage breast cancer were treated with NAC...
April 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29602210/predicting-neo-adjuvant-chemotherapy-response-and-progression-free-survival-of-locally-advanced-breast-cancer-using-textural-features-of-intratumoral-heterogeneity-on-f-18-fdg-pet-ct-and-diffusion-weighted-mr-imaging
#17
Hai-Jeon Yoon, Yemi Kim, Jin Chung, Bom Sahn Kim
Predicting response to neo-adjuvant chemotherapy (NAC) and survival in locally advanced breast cancer (LABC) is important. This study investigated the prognostic value of tumor heterogeneity evaluated with textural analysis through F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and diffusion-weighted imaging (DWI). We enrolled 83 patients with LABC who had completed NAC and curative surgery. Tumor texture indices from pretreatment FDG PET and DWI were extracted from histogram analysis and 7 different parent matrices: co-occurrence matrix, the voxel-alignment matrix, neighborhood intensity difference matrix, intensity size-zone matrix (ISZM), normalized gray-level co-occurrence matrix (NGLCM), neighboring gray-level dependence matrix (NGLDM), and texture spectrum matrix...
March 30, 2018: Breast Journal
https://www.readbyqxmd.com/read/29595035/prognostic-role-of-delay-before-radical-cystectomy-retrospective-analysis-of-a-single-centre-cohort-with-376-patients
#18
Alessandro Antonelli, Stefania Zamboni, Carlotta Palumbo, Sandra Belotti, Marco Lattarulo, Maria Furlan, Maria C Marconi, Luca Cristinelli, Claudio Simeone
BACKGROUND: According to International Guidelines radical cystectomy (RC) should not be delayed over 90 days to prevent the risk of intercurrent progression and worse survival. Nevertheless, such a recommendation relies on a few retrospective studies reaching non univocal conclusions. Aim of the present study is to investigate if the latency between diagnosis and cystectomy (LDC) is related to prognosis after RC. METHODS: Retrospective analysis of database collecting complete information on patients undergone RC at single institution since 2004...
March 28, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29594445/the-prognostic-implications-of-primary-tumor-location-on-recurrence-in-early-stage-colorectal-cancer-with-no-associated-risk-factors
#19
Sung Il Kang, Duck-Woo Kim, Yoonjin Kwak, Hye-Seung Lee, Min Hyun Kim, Myung Jo Kim, Heung-Kwon Oh, Sung-Bum Kang
PURPOSE: Recently, several reports have suggested that tumor location serves as a prognostic biomarker in advanced colorectal cancer. However, the prognostic implication of tumor location in patients with early-stage colorectal cancer remains unclear. This study was aimed to examine the prognostic implication of tumor location in patients with early-stage colorectal cancer. METHODS: Patients with stage I and low-risk stage II colorectal cancer, treated with radical surgery in a hospital setting between May 2003 and September 2014, were retrospectively reviewed...
March 28, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29587322/-the-role-of-biomarkers-in-the-diagnosis-prognosis-and-therapy-of-patients-with-immuno-oncological-treatments-of-genito-urinary-carcinomas
#20
Eva Compérat, Caroline Eymerit, Julien Moroch, Justin Varinot
In recent years, fundamental research has yielded new insights into tumour biology, and new treatments have been developed. This review highlights the role of the pathologist and how he can support clinicians to find the right treatment for each patient. We explain the problems of the molecular subgroups of bladder cancer, the role of neo-adjuvant chemotherapy in the context of these findings, and show the important role of checkpoint inhibitors. Furthermore we focus on kidney cancer, with the clear cell carcinoma as the most frequent tumour type...
April 2018: Aktuelle Urologie
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