keyword
https://read.qxmd.com/read/38475859/analysis-of-related-factors-for-neuropsychiatric-comorbidities-in-children-with-epilepsy
#21
JOURNAL ARTICLE
Xin-Ying Zhang, Meng Sun, Jiang-Ya Wang, Fang-Fang Du, Xue-Fei Liu, Ling-Jun Wang, Zhen-De Hou, Ya-Ying Cheng
OBJECTIVE: To analyze the risk factors affecting psychiatric behavior and study the psychobehavioral conditions of children with epilepsy. METHOD: We randomly selected and enrolled 294 children with epilepsy who visited and were hospitalized in the pediatric clinic of Hebei General Hospital between January 2017 and January 2022, as the study participants. We comprehensively assessed their cognitive functions using the Gesell development schedule or Wechsler Intelligence Scales...
March 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38475798/long-term-outcome-in-new-onset-refractory-status-epilepticus-a-retrospective-study
#22
JOURNAL ARTICLE
Federica Stretti, Stefan Yu Bögli, Francesca Casagrande, Amanda Eisele, Marian Galovic, Emanuela Keller, Giovanna Brandi
BACKGROUND: New onset refractory status epilepticus (NORSE) is a neurologic emergency without an immediately identifiable cause. The complicated and long ICU stay of the patients can lead to perceiving a prolongation of therapies as futile. However, a recovery is possible even in severe cases. This retrospective study investigates ICU treatments, short- and long-term outcome and ethical decisions of a case series of patients with NORSE. METHODS: Overall, 283 adults were admitted with status epilepticus (SE) to the Neurocritical Care Unit of the University Hospital Zurich, Switzerland, between 01...
March 12, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38469308/case-report-successful-treatment-of-an-anti-d2r-and-dppx-antibody-associated-autoimmune-encephalitis-patient-with-high-dose-methylprednisolone-and-intravenous-immunoglobulin
#23
Zhangliang Lin, Feng Zhou, Lili Ni, Shiye Dong, Guoping Fu, Jiangman Zhao
BACKGROUND: Autoimmune encephalitis is a neurological condition caused by abnormal immune responses, manifesting as cognitive impairments, behavioral abnormalities, and seizures. Its diagnosis depends on the detecting neuronal surface antibodies in serum or cerebrospinal fluid. Despite recent advances in understanding, clinical recognition remains challenging, especially with rare antibodies such as anti-dopamine D2 receptor (D2R) and anti-dipeptidyl-peptidase-like protein 6 (DPPX) antibodies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38468526/increased-cyclic-adenosine-monophosphate-responsive-element-is-closely-associated-with-the-pathogenesis-of-drug-resistant-epilepsy
#24
JOURNAL ARTICLE
Jing-Xuan Li, Dai Shi, Si-Ying Ren, Guo-Feng Wu
BACKGROUND: Drug-resistant epilepsy (DRE) is a refractory neurological disorder. There is ample evidence that suggest that γ-aminobutyric acid-a (GABAA) receptors could be one of the mechanisms responsible for the development of drug resistance in epilepsy. It is also known that the cAMP response element binding protein (CREB) plays a possible key role in the transcriptional regulation of GABAA. OBJECTIVE: This study explores the role of CREB in the development of DRE and the effect of CREB on GABA-related receptors in DRE...
March 8, 2024: Current Neurovascular Research
https://read.qxmd.com/read/38466294/treatment-of-refractory-status-epilepticus-with-continuous-intravenous-anesthetic-drugs-a-systematic-review
#25
JOURNAL ARTICLE
Yu Kan Au, Mohammed F Kananeh, Rahul Rahangdale, Timothy Eoin Moore, Gregory A Panza, Nicolas Gaspard, Lawrence J Hirsch, Andres Fernandez, Syed Omar Shah
IMPORTANCE: Multiple continuous intravenous anesthetic drugs (CIVADs) are available for the treatment of refractory status epilepticus (RSE). There is a paucity of data comparing the different types of CIVADs used for RSE. OBJECTIVE: To systematically review and compare outcome measures associated with the initial CIVAD choice in RSE in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. EVIDENCE REVIEW: Data sources included English and non-English articles using Embase, MEDLINE, PubMed, and Web of Science (January 1994-June 2023) as well as manual search...
March 11, 2024: JAMA Neurology
https://read.qxmd.com/read/38465051/therapeutic-time-window-with-dwi-adc-diffusion-weighted-imaging-apparent-diffusion-coefficient-match-and-periodic-discharges-for-status-epilepticus
#26
Daiki Gohara, Shuichiro Neshige, Hideaki Sakahara, Narumi Ohno, Hirofumi Maruyama
A man in his 70s with alcoholic dementia was admitted for acute, prolonged impaired consciousness. Blood and cerebrospinal fluid findings were unremarkable. Brain MRI revealed multiple high-signal cortical regions. Following diazepam and levetiracetam administration, electroencephalography (EEG) revealed <1 Hz lateralized periodic discharges, indicating that the seizures were ceasing. The periodic discharges had disappeared during the gradual recovery process by day 10; however, cortical arterial spin labeling findings persisted only in regions exhibiting cytotoxic edema...
February 2024: Curēus
https://read.qxmd.com/read/38461760/efficacy-and-safety-of-ketamine-for-pediatric-and-adolescent-super-refractory-status-epilepticus-and-the-effect-of-cerebral-inflammatory-conditions
#27
JOURNAL ARTICLE
Ichiro Kuki, Takeshi Inoue, Masataka Fukuoka, Megumi Nukui, Hideo Okuno, Kiyoko Amo, Yasunori Otsuka, Junichi Ishikawa, Hiroshi Rinka, Atushi Ujiro, Masao Togawa, Masashi Shiomi, Shin Okazaki
OBJECTIVE: To investigate the short-term benefits and adverse effects of ketamine in the treatment of pediatric and adolescent super-refractory status epilepticus (SRSE), with a focus on the inflammatory etiology. METHODS: This retrospective observational cohort study included a consecutive series of 18 pediatric to adolescent patients with SRSE admitted between 2008 and 2023 and treated with ketamine. Seizure frequency per hour before and after ketamine administration and response rate were calculated...
March 6, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38456595/surgical-management-of-status-epilepticus-a-systematic-review
#28
REVIEW
Rohan Jha, Sarah E Blitz, Melissa M J Chua, Aaron E L Warren, Jong Woo Lee, John D Rolston
Status Epilepticus (SE), unresponsive to medical management, is associated with high morbidity and mortality. Surgical management is typically considered in these refractory cases. The best surgical approach for affected patients remains unclear; however, given the lack of controlled trials exploring the role of surgery. We performed a systematic review according to PRIMSA guidelines, including case reports and series describing surgical interventions for patients in SE. Cases (157 patients, median age 12.9 years) were followed for a median of 12 months...
March 8, 2024: Epilepsia Open
https://read.qxmd.com/read/38454370/novel-cad-gene-mutations-in-a-boy-with-developmental-and-epileptic-encephalopathy-50-with-dramatic-response-to-uridine-therapy-a-case-report-and-a-review-of-the-literature
#29
REVIEW
Lifen Duan, Lei Ye, Runxiu Yin, Ying Sun, Wei Yu, Yi Zhang, Haiyan Zhong, Xinhua Bao, Xin Tian
BACKGROUND: Developmental and epileptic encephalopathy-50 (DEE-50) is a rare clinical condition believed to be caused by a mutation in the CAD gene and is associated with a bleak prognosis. CAD-related diseases have a wide range of clinical manifestations and other symptoms that may be easily overlooked. Like other rare diseases, the clinical manifestations and the treatment of DEE-50 necessitate further investigation. CASE PRESENTATION: A 1-year-old male patient presented with developmental delay, seizures, and anaemia at 3 months of age...
March 7, 2024: BMC Pediatrics
https://read.qxmd.com/read/38453164/eeg-and-video-documentation-of-benzodiazepine-challenge-in-catatonic-stupor-a-case-report
#30
Hidetaka Tamune, Yu Tsukioka, Shota Sakuma, Daiki Taira, Yoshie Takaoka, Naoto Tamura, Tadafumi Kato
INTRODUCTION: Catatonia, a psychomotor disorder characterized by diverse clinical signs, including stupor and mutism, remains elusive in its causes and a challenge to diagnose. Moreover, it is often underrecognized due to its resemblance to disorders of consciousness. However, when diagnosing catatonia, an antipsychotic medication may exacerbate the condition. The first-line treatment typically includes benzodiazepines and/or electroconvulsive therapy (ECT). CASE REPORT: A 60-year-old woman with systemic lupus erythematosus (SLE) and epilepsy presented with catatonic stupor...
March 7, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38447759/binding-of-the-monoacylglycerol-lipase-magl-radiotracer-3-h-t-401-in-the-rat-brain-after-status-epilepticus
#31
JOURNAL ARTICLE
Jens D Mikkelsen, Sanjay S Aripaka, Cansu B Egilmez, Burcu A Pazarlar
OBJECTIVES: Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase considered a potential novel drug target for the treatment of CNS disorders including epilepsy. Here we examined MAGL levels in a rat model of epilepsy. METHODS: Autoradiography has been used to validate the binding properties of the MAGL radiotracer, [3 H]T-401, in the rat brain, and to explore spatial and temporal changes in binding levels in a model of temporal lobe epilepsy model using unilateral intra-hippocampal injections of kainic acid (KA) in rats...
March 5, 2024: Neurochemistry International
https://read.qxmd.com/read/38446345/long-term-effect-of-multichannel-tdcs-protocol-in-patients-with-central-cortex-epilepsies-associated-with-epilepsia-partialis-continua
#32
JOURNAL ARTICLE
M Daoud, C Durelle, A Fierain, El Youssef N, F Wendling, G Ruffini, P Benquet, F Bartolomei
Epilepsia partialis continua (EPC) is a rare type of focal motor status epilepticus that causes continuous muscle jerking in a specific part of the body. Experiencing this type of seizure, along with other seizure types, such as focal motor seizures and focal to bilateral tonic-clonic seizures, can result in a disabling situation. Non-invasive brain stimulation methods like transcranial direct current stimulation (tDCS) show promise in reducing seizure frequency (SF) when medications are ineffective. However, research on tDCS for EPC and related seizures is limited...
March 6, 2024: Brain Topography
https://read.qxmd.com/read/38441162/status-epilepticus-what-s-new-for-the-intensivist
#33
JOURNAL ARTICLE
Sarah Benghanem, Estelle Pruvost Robieux, Aidan Neligan, Matthew C Walker
PURPOSE OF REVIEW: Status epilepticus (SE) is a common neurologic emergency affecting about 36.1/100 000 person-years that frequently requires intensive care unit (ICU) admission. There have been advances in our understanding of epidemiology, pathophysiology, and EEG monitoring of SE, and there have been large-scale treatment trials, discussed in this review. RECENT FINDINGS: Recent changes in the definitions of SE have helped guide management protocols and we have much better predictors of outcome...
February 14, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38436644/gender-related-variation-expressions-of-neuroplastin-traf6-glua1-gaba-a-receptor-and-pmca-in-cortex-hippocampus-and-brainstem-in-an-experimental-epilepsy-model
#34
JOURNAL ARTICLE
Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyüz
Epileptic seizures are seen as a result of changing excitability balance depending on the deterioration in synaptic plasticity in the brain. Neuroplastin, and its related molecules which are known to play a role in synaptic plasticity, neurotransmitter activities that provide balance of excitability and, different neurological diseases, have not been studied before in epilepsy. In this study, a total of 34 Sprague-Dawley male and female rats, 2 months old, weighing 250-300 g were used. The epilepsy model in rats was made via pentylenetetrazole (PTZ)...
March 2024: Synapse
https://read.qxmd.com/read/38432120/outcomes-and-predictors-of-seizure-recurrence-in-post-stroke-epilepsy-a-retrospective-hospital-based-study
#35
JOURNAL ARTICLE
Erum Shariff, Saima Nazish, Rizwana Shahid, Azra Zafar, Zakia M Yasawy, Norah A AlKhaldi, Danah AlJaafari, Nehad M Soltan, Foziah Alshamrani, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Rana Alameri, Majed Alabdali
BACKGROUND: The occurrence of seizures following a stroke is a well-recognized complication associated with a significant increase in morbidity and mortality. Despite the numerous studies examining outcomes and risk factors related to post-stroke seizures (PSS), there remains a lack of clarity regarding the clinical characteristics, treatment, and PSS recurrence (PSSR) rates in patients experiencing their initial episode of PSS. PURPOSE: This study aimed to determine the risk factors for developing recurrent seizures after first PSS and their effects on functional outcomes and mortality...
February 27, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38430119/second-line-immunotherapy-in-new-onset-refractory-status-epilepticus
#36
REVIEW
Aurélie Hanin, Eyal Muscal, Lawrence J Hirsch
Several pieces of evidence suggest immune dysregulation could trigger the onset and modulate sequelae of new onset refractory status epilepticus (NORSE), including its subtype with prior fever known as febrile infection-related epilepsy syndrome (FIRES). Consensus-driven recommendations have been established to guide the initiation of first- and second-line immunotherapies in these patients. Here, we review the literature to date on second-line immunotherapy for NORSE/FIRES, presenting results from 28 case reports and series describing the use of anakinra, tocilizumab, or intrathecal dexamethasone in 75 patients with NORSE...
March 2, 2024: Epilepsia
https://read.qxmd.com/read/38428176/comprehensive-review-of-status-gelasticus-diagnostic-challenges-and-therapeutic-insights
#37
REVIEW
Antonio Gennaro Nicotera, Giulia Spoto, Greta Amore, Ambra Butera, Gabriella Di Rosa
Status gelasticus is a rare form of status epilepticus characterized by prolonged and/or clustered gelastic seizures. The review encompasses an analysis of cases reported in the literature, focusing on causes, clinical-electroencephalographic features, and therapeutic interventions. The study reveals the challenges in defining and understanding status gelasticus due to its diverse etiologies and limited reported cases. The association with hypothalamic hamartomas and other brain abnormalities underscores the importance of thorough evaluations...
February 29, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38417192/comparing-the-efficacy-of-anti-seizure-medications-using-matched-cohorts-on-a-large-insurance-claims-database
#38
JOURNAL ARTICLE
Yoav Kan-Tor, Lior Ness, Liran Szlak, Felix Benninger, Sivan Ravid, Michal Chorev, Michal Rosen-Zvi, Yishai Shimoni, Robert S Fisher
Epilepsy is a severe chronic neurological disease affecting 60 million people worldwide. Primary treatment is with anti-seizure medicines (ASMs), but many patients continue to experience seizures. We used retrospective insurance claims data on 280,587 patients with uncontrolled epilepsy (UE), defined as status epilepticus, need for a rescue medicine, or admission or emergency visit for an epilepsy code. We conducted a computational risk ratio analysis between pairs of ASMs using a causal inference method, in order to match 1034 clinical factors and simulate randomization...
March 2024: Epilepsy Research
https://read.qxmd.com/read/38411568/efficacy-and-safety-of-corticosteroids-and-acth-in-epileptic-syndromes-beyond-infantile-epileptic-spasms-syndrome-iess-a-systematic-review-and-meta-analysis
#39
REVIEW
Rudolf Korinthenberg, Thomas Bast, Edda Haberlandt, Ulrich Stephani, Adam Strzelczyk, Gerta Rücker
We conducted a systematic review investigating the efficacy and tolerability of adrenocorticotropic hormone (ACTH) and corticosteroids in children with epilepsies other than infantile epileptic spasm syndrome (IESS) that are resistant to anti-seizure medication (ASM). We included retrospective and prospective studies reporting on more than five patients and with clear case definitions and descriptions of treatment and outcome measures. We searched multiple databases and registries, and we assessed the risk of bias in the selected studies using a questionnaire based on published templates...
February 27, 2024: Epilepsia
https://read.qxmd.com/read/38410694/role-of-trak1-variants-in-epilepsy-genotype-phenotype-analysis-in-a-pediatric-case-of-epilepsy-with-developmental-disorder
#40
JOURNAL ARTICLE
Ren-Ke Li, Yu-Rong Xiong, Shu-Jing Pan, Wen-Ting Lei, Xiao-Mei Shu, Xiao-Qi Shi, Mao-Qiang Tian
PURPOSE: The TRAK1 gene is mapped to chromosome 3p22.1 and encodes trafficking protein kinesin binding 1. The aim of this study was to investigate the genotype-phenotype of TRAK1 -associated epilepsy. METHODS: Trio-based whole-exome sequencing was performed on a cohort of 98 patients with epilepsy of unknown etiologies. Protein modeling and the VarCards database were used to predict the damaging effects of the variants. Detailed neurological phenotypes of all patients with epilepsy having TRAK1 variants were analyzed to assess the genotype-phenotype correlations...
2024: Frontiers in Molecular Neuroscience
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