keyword
https://read.qxmd.com/read/36543346/new-antibiotics-for-gram-negative-pneumonia
#21
REVIEW
Matteo Bassetti, Federica Magnè, Daniele Roberto Giacobbe, Lorenzo Bini, Antonio Vena
Pneumonia is frequently encountered in clinical practice, and Gram-negative bacilli constitute a significant proportion of its aetiology, especially when it is acquired in a hospital setting. With the alarming global rise in multidrug resistance in Gram-negative bacilli, antibiotic therapy for treating patients with pneumonia is challenging and must be guided by in vitro susceptibility results. In this review, we provide an overview of antibiotics newly approved for the treatment of pneumonia caused by Gram-negative bacilli...
December 31, 2022: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/36365188/membrane-vesicles-derived-from-gut-microbiota-and-probiotics-cutting-edge-therapeutic-approaches-for-multidrug-resistant-superbugs-linked-to-neurological-anomalies
#22
REVIEW
Prakhar Srivastava, Kwang-Sun Kim
Multidrug-resistant (MDR) superbugs can breach the blood-brain barrier (BBB), leading to a continuous barrage of pro-inflammatory modulators and induction of severe infection-related pathologies, including meningitis and brain abscess. Both broad-spectrum or species-specific antibiotics (β-lactamase inhibitors, polymyxins, vancomycin, meropenem, plazomicin, and sarecycline) and biocompatible poly (lactic-co-glycolic acid) (PLGA) nanoparticles have been used to treat these infections. However, new therapeutic platforms with a broad impact that do not exert off-target deleterious effects are needed...
November 3, 2022: Pharmaceutics
https://read.qxmd.com/read/36312785/prevalence-of-esbl-producing-enterobacter-species-resistant-to-carbapenems-in-iran-a-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Farzad Khademi, Hamid Vaez, Zohreh Neyestani, Amirhossein Sahebkar
Background: Carbapenems are the last-line therapy for multidrug-resistant (MDR) infections caused by Enterobacterales, including those caused by Enterobacter species. However, the recent emergence of carbapenem-resistant (CR) and extended-spectrum β -lactamase (ESBL)-producing Enterobacteriaceae pathogens, which are resistant to nearly all antibiotics, has raised concerns among international healthcare organizations. Hence, because there is no comprehensive data in Iran, the current study aimed to evaluate the prevalence of antibiotic resistance among Enterobacter species, especially CR and ESBL-producing strains, in Iran...
2022: International Journal of Microbiology
https://read.qxmd.com/read/36201154/correction-to-epidemiology-and-in-vitro-activity-of-ceftazidime-avibactam-meropenem-vaborbactam-imipenem-relebactam-eravacycline-plazomicin-and-comparators-against-greek-carbapenemase-producing-klebsiella-pneumoniae-isolates
#24
Sofia Maraki, Viktoria Eirini Mavromanolaki, Eleni Magkafouraki, Panagiotis Moraitis, Dimitra Stafylaki, Anna Kasimati, Effie Scoulica
No abstract text is available yet for this article.
October 6, 2022: Infection
https://read.qxmd.com/read/36122516/use-of-pharmacokinetic-pharmacodynamic-approaches-for-dose-optimization-a-case-study-of-plazomicin
#25
REVIEW
Courtney L Luterbach, Gauri G Rao
With limited treatment options available for multidrug-resistant bacteria, dose optimization is critical for achieving effective drug concentrations at the site of infection. Yet, selecting an appropriate dose and appropriate time to administer the dose with dosing frequency requires extensive understanding of the interplay between drug pharmacokinetics/pharmacodynamics (PK/PD), the host immune system, and bacterial-resistant mechanisms. Model-informed dose optimization (MIDO) uses PK/PD models (e.g. population PK, mechanism-based models, etc...
September 16, 2022: Current Opinion in Microbiology
https://read.qxmd.com/read/36092826/efficacy-and-safety-of-plazomicin-in-the-treatment-of-enterobacterales-infections-a-meta-analysis-of-randomized-controlled-trials
#26
REVIEW
Kaicheng Yan, Beibei Liang, Guanxuanzi Zhang, Jin Wang, Man Zhu, Yun Cai
BACKGROUND: In the present study, we aimed to compare the efficacy and safety of plazomicin with comparators for the treatment of Enterobacterales infections. METHODS: Randomized controlled trials (RCTs) assessing plazomicin for Enterobacterales infections were searched on the PubMed, Embase, and Cochrane Library databases. Meta-analyses were used to evaluate the efficacy and safety in RCTs. RESULTS: A total of 3 RCTs consisting of 761 patients were included in the present analysis...
September 2022: Open Forum Infectious Diseases
https://read.qxmd.com/read/35942725/new-antimicrobial-treatment-options-for-severe-gram-negative-infections
#27
REVIEW
Lauren Hetzler, Marin H Kollef, Valerie Yuenger, Scott T Micek, Kevin D Betthauser
PURPOSE OF REVIEW: This review will provide rationale for the development of new antibiotics to treat severe or multidrug-resistant (MDR) Gram-negative infections. It will also provide an overview of recently approved and pipeline antibiotics for severe/MDR Gram-negative infections. RECENT FINDINGS: MDR Gram-negative infections are recognized as critical threats by global and national organizations and carry a significant morbidity and mortality risk. Increasing antibiotic resistance amongst Gram-negative bacteria, including carbapenem-resistant Acinetobacter baumannii , extended-spectrum β-lactamase-producing Enterobacterales, carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa , with difficult-to-treat-resistance has made both empiric and definitive treatment of these infections increasingly problematic...
October 1, 2022: Current Opinion in Critical Care
https://read.qxmd.com/read/35921328/structural-elucidation-of-substrate-bound-aminoglycoside-acetyltransferase-3-iiia
#28
JOURNAL ARTICLE
Michał Zieliński, Jonathan Blanchet, Sophia Hailemariam, Albert M Berghuis
Canonical aminoglycosides are a large group of antibiotics, where the part of chemical diversity stems from the substitution of the neamine ring system on positions 5 and 6. Certain aminoglycoside modifying enzymes can modify a broad range of 4,5- and 4,6-disubstituted aminoglycosides, with some as many as 15. This study presents the structural and kinetic results describing a promiscuous aminoglycoside acetyltransferase AAC(3)-IIIa. This enzyme has been crystallized in ternary complex with coenzyme A and 4,5- and 4,6-disubstituted aminoglycosides...
2022: PloS One
https://read.qxmd.com/read/35896514/characterization-of-resistance-to-newer-antimicrobials-among-carbapenem-resistant-klebsiella-pneumoniae-in-the-post-acute-care-setting
#29
JOURNAL ARTICLE
Helen L Zhang, Kyle J Gontjes, Jennifer H Han, Kevin Alby, Zena Lapp, Evan Snitkin, Ellie J C Goldstein, Sean Muldoon, Pam Tolomeo, Ebbing Lautenbach
We assessed susceptibility patterns to newer antimicrobial agents among clinical carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from patients in long-term acute-care hospitals (LTACHs) from 2014 to 2015. Meropenem-vaborbactam and imipenem-relebactam nonsusceptibility were observed among 9.9% and 9.1% of isolates, respectively. Nonsusceptibility to ceftazidime-avibactam (1.1%) and plazomicin (0.8%) were uncommon.
July 28, 2022: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/35822495/in-vitro-activity-of-plazomicin-meropenem-vaborbactam-and-omadacycline-against-carbapenem-resistant-gram-negative-isolates-in-egypt
#30
JOURNAL ARTICLE
Mona Abd El-Aziz Gadallah, Wasila Moursy El-Sayed, Mohammed Zakaria Hussien, Mohammed Ahmed Elheniedy, Sara Youssef Maxwell
Anti-microbial resistance is an escalating worldwide threat. Thus, there is an utmost necessity for the introduction of novel anti-microbial agents. This research aimed to evaluate the in-vitro activity of plazomicin, meropenem-vaborbactam, and omadacycline against carbapenem-resistant Gram-negative isolates gathered from one Egyptian University group of Hospitals. 210 intensive care units (ICU) and 113 non-ICU samples were included. Resistance to carbapenems was reported in 37.5% and 21.05% of the isolated Gram-negative ICU and non-ICU organisms respectively (P < 0...
July 13, 2022: Journal of Chemotherapy
https://read.qxmd.com/read/35822340/comparing-the-activity-of-novel-antibiotic-agents-against-carbapenem-resistant-enterobacterales-clinical-isolates
#31
JOURNAL ARTICLE
Pranita D Tamma, Yehudit Bergman, Emily B Jacobs, Jae Hyoung Lee, Shawna Lewis, Sara E Cosgrove, Patricia J Simner
OBJECTIVE: We compared the activity of 8 novel β-lactam and tetracycline-derivative antibiotics against a cohort of clinical carbapenem-resistant Enterobacterales (CRE) isolates and investigated the incremental susceptibility benefit of the addition of an aminoglycoside, fluoroquinolone, or polymyxin to the β-lactam agents to assist with empiric antibiotic decision making. METHODS: A collection of consecutive CRE clinical isolates from unique patients at 3 US hospitals (2016-2021) was assembled...
July 13, 2022: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/35704736/in-vitro-activity-of-plazomicin-against-carbapenem-resistant-klebsiella-pneumoniae-strains
#32
JOURNAL ARTICLE
Z Demirbas, H Selcuk Ozger, Serap Suzuk-Yildiz, Zekiye Bakkaloglu, Murat Dizbay
BACKGROUND: In our study, we evaluated the in vitro activities of plazomicin, amikacin, gentamicin, and tobramycin among fifty carbapenem resistant Klebsiella pneumoniae (CR-Kp) isolates. Aminoglycoside resistance genes in selected CR-Kp strains were also examined. METHODS: Minimum inhibitory concentration (MIC) of meropenem, plazomicin, tobramycin, gentamicin, and amikacin were determined by gradient test (G-test) method. In all strains carbapenemase activity was assessed by polymerase chain reaction (PCR)...
June 1, 2022: Clinical Laboratory
https://read.qxmd.com/read/35686013/escaping-mechanisms-of-eskape-pathogens-from-antibiotics-and-their-targeting-by-natural-compounds
#33
JOURNAL ARTICLE
Ragi Jadimurthy, Shilpa Borehalli Mayegowda, S Chandra Nayak, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal S Rangappa
The microorganisms that have developed resistance to available therapeutic agents are threatening the globe and multidrug resistance among the bacterial pathogens is becoming a major concern of public health worldwide. Bacteria develop protective mechanisms to counteract the deleterious effects of antibiotics, which may eventually result in loss of growth-inhibitory potential of antibiotics. ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp...
June 2022: Biotechnology Reports
https://read.qxmd.com/read/35669117/efficacy-and-in-vitro-activity-of-novel-antibiotics-for-infections-with-carbapenem-resistant-gram-negative-pathogens
#34
REVIEW
Flora Cruz-López, Adrian Martínez-Meléndez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Héctor J Maldonado-Garza, Elvira Garza-González
Infections by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat using available antibiotics. Overuse of carbapenems has contributed to widespread resistance to these antibiotics; as a result, carbapenem-resistant Enterobacterales (CRE), A. baumannii (CRAB), and P. aeruginosa (CRPA) have become common causes of healthcare-associated infections. Carbapenems, tigecycline, and colistin are the last resource antibiotics currently used; however, multiple reports of resistance to these antimicrobial agents have been documented worldwide...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/35625223/new-drugs-for-the-treatment-of-pseudomonas-aeruginosa-infections-with-limited-treatment-options-a-narrative-review
#35
REVIEW
Angela Raffaella Losito, Francesca Raffaelli, Paola Del Giacomo, Mario Tumbarello
P. aeruginosa is still one of the most threatening pathogens responsible for serious hospital-acquired infections. It is intrinsically resistant to many antimicrobial agents and additional acquired resistance further complicates the management of such infections. High rates of combined antimicrobial resistance persist in many countries, especially in the eastern and south-eastern parts of Europe. The aim of this narrative review is to provide a comprehensive assessment of the epidemiology, latest data, and clinical evidence on the current and new available drugs active against P...
April 26, 2022: Antibiotics
https://read.qxmd.com/read/35107163/aminoglycoside-resistance-gene-signatures-are-predictive-of-aminoglycoside-mics-for-carbapenem-resistant-klebsiella-pneumoniae
#36
JOURNAL ARTICLE
Yanqin Huang, Amisha P Rana, Eric Wenzler, Egon A Ozer, Fiorella Krapp, Jürgen B Bulitta, Alan R Hauser, Zackery P Bulman
BACKGROUND: Aminoglycoside-containing regimens may be an effective treatment option for infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but aminoglycoside-resistance genes are common in these strains. The relationship between the aminoglycoside-resistance genes and aminoglycoside MICs remains poorly defined. OBJECTIVES: To identify genotypic signatures capable of predicting aminoglycoside MICs for CR-Kp. METHODS: Clinical CR-Kp isolates (n = 158) underwent WGS to detect aminoglycoside-resistance genes...
February 2, 2022: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/35107156/aminoglycoside-resistance-gene-signatures-are-predictive-of-aminoglycoside-mics-for-carbapenem-resistant-klebsiella-pneumoniae
#37
JOURNAL ARTICLE
Yanqin Huang, Amisha P Rana, Eric Wenzler, Egon A Ozer, Fiorella Krapp, Jürgen B Bulitta, Alan R Hauser, Zackery P Bulman
BACKGROUND: Aminoglycoside-containing regimens may be an effective treatment option for infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but aminoglycoside-resistance genes are common in these strains. The relationship between the aminoglycoside-resistance genes and aminoglycoside MICs remains poorly defined. OBJECTIVES: To identify genotypic signatures capable of predicting aminoglycoside MICs for CR-Kp. METHODS: Clinical CR-Kp isolates (n = 158) underwent WGS to detect aminoglycoside-resistance genes...
February 2, 2022: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/35063651/carbapenemase-producing-enterobacterales-infections-recent-advances-in-diagnosis-and-treatment
#38
REVIEW
Yu-Lin Lee, Hsien-Meng Chen, Ing-Moi Hii, Po-Ren Hsueh
Increasing carbapenem resistance in Enterobacterales poses a threat to public health. In recent decades, this increase in carbapenem resistance has been caused by the global dissemination of carbapenemase-producing Enterobacterales (CPE). Carbapenemases are members of the β-lactamases that are divided into classes A, B and D based on their molecular structures. Although certain traditionally used antibiotics, such as amikacin, polymyxins, tigecycline and fosfomycin, may remain effective against some CPE, their clinical use is limited owing to adverse effects, including renal toxicity, tissue penetration or the requirement for combination treatment...
February 2022: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/35034551/meropenem-vaborbactam-a-critical-positioning-for-the-management-of-infections-by-carbapenem-resistant-enterobacteriaceae
#39
JOURNAL ARTICLE
Maria Mouktaroudi, Antigone Kotsaki, Evangelos J Giamarellos-Bourboulis
INTRODUCTION: The review aims to review the positioning of meropenem-vaborbactam in clinical practice, taking into consideration the characteristics of other available drugs, namely ceftazidime-avibactam, plazomicin, and colistin. AREAS COVERED: The search terms 'meropenem-vaborbactam' or RX7009 for the years 2006 until 2021 were used. EXPERT OPINION: Coupling of meropenem with the cyclic boronate derivative varobactam enhances considerably the in vitro intrinsic activity of meropenem against isolates producing KPC ( Klebsiella pneumoniae- producing carbapenemase)...
January 26, 2022: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/34939541/discovery-and-development-of-antibacterial-agents-fortuitous-and-designed
#40
REVIEW
Ravleen Kaur, Pooja Rani, Atanas G Atanasov, Qushmua Alzahrani, Reena Gupta, Bhupinder Kapoor, Monica Gulati, Pooja Chawla
Today, antibacterial drug resistance has turned into a significant public health issue. Repeated intake, suboptimal and/or unnecessary use of antibiotics, and, additionally, the transfer of resistance genes are the critical elements that make microorganisms resistant to conventional antibiotics. A substantial number of antibacterials that were successfully utilized earlier for prophylaxis and therapeutic purposes have been rendered inadequate due to this phenomenon. Therefore, the exploration of new molecules has become a continuous endeavour...
2022: Mini Reviews in Medicinal Chemistry
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