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Bone research

Lívia Bonjardim Lima, Nayara Ribeiro de Freitas, Veridiana Resende Novais, Paulo Cézar Simamoto Júnior
PURPOSE: To assess studies on edentulous patients rehabilitated using mandibular implant-supported profile prostheses and analyze the impact of different numbers of implants used on the implant survival rate, peri-implant bone loss, and prosthesis survival rate. MATERIALS AND METHODS: This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement and was registered on PROSPERO. The PubMed/MEDLINE database was searched for articles published before July 18, 2016...
July 2018: International Journal of Oral & Maxillofacial Implants
Chandkiram Gautam, Dibyendu Chakravarty, Amarendra Gautam, Chandra Sekhar Tiwary, Cristiano Francisco Woellner, Vijay Kumar Mishra, Naseer Ahmad, Sehmus Ozden, Sujin Jose, Santoshkumar Biradar, Robert Vajtai, Ritu Trivedi, Douglas S Galvao, Pulickel M Ajayan
Recent advances and demands in biomedical applications drive a large amount of research to synthesize easily scalable low-density, high-strength, and wear-resistant biomaterials. The chemical inertness with low density combined with high strength makes h-BN one of the promising materials for such application. In this work, three-dimensional hexagonal boron nitride (h-BN) interconnected with boron trioxide (B2 O3 ) was prepared by easily scalable and energy efficient spark plasma sintering (SPS) process. The composite structure shows significant densification (1...
June 30, 2018: ACS Omega
Deborah Vickers, Angela Canas, Aneeka Degun, John Briggs, Mina Bingham, Joseph Toner, Huw Cooper, Sarah Rogers, Stacey Cooper, Richard Irving, Patrick Spielman, Samantha Batty, Stephen Jones, Abi Asher, Mark Chung, Neil Donnelly, Anna Skibinska, Robert Gardner, Chris Raine, Rachel Andrew, Kevin Green, Hashmat Ghulam, Terry Nunn, Dan Jiang, Severin Fürhapter, Michael Urban, Kate Hanvey, Sarah Flynn, David Lovegrove, Shakeel Saeed
Background: The Vibrant Soundbridge middle ear implant and the Bonebridge bone conducting hearing device are hearing implants that use radio frequency transmission to send information from the sound processor to the internal transducer. This reduces the risk of skin problems and infection but requires a more involved surgical procedure than competitor skin penetrating devices. It is not known whether more complex surgery will lead to additional complications. There is little information available on the reliability of these systems and adverse medical or surgical events...
June 2018: Contemporary Clinical Trials Communications
M Stefaniuk-Szmukier, K Ropka-Molik, K Piórkowska, K Żukowski, M Bugno-Poniewierska
The impact of exercises on young developing organisms is still of interest to researchers. Similarly like Thoroughbreds, Arabian horses competing at the race track. The high percent of lameness and loss of days in training are often the result of weakness in the condition of the musculoskeletal system. The objective of the presented study was to identify by RNA-Seq method, the possible skeletal system originating transcriptomic profile in peripheral blood of Arabian horses undergoing race training. Obtained results showed that one of the most significantly deregulated pathway involved in bone homeostasis was those involved in osteoclast differentiation...
July 15, 2018: Gene
Zheng-Qi Chen, Chong-Ren Wang, Xiao-Jun Ma, Wei Sun, Jia-Kang Shen, Meng-Xiong Sun, Ze-Ze Fu, Ying-Qi Hua, Zheng-Dong Cai
OBJECTIVE: To reveal the alterations in quality of life (QOL) in bone metastases patients after magnetic resonance guided focused ultrasound (MRgFUS). METHODS: This retrospective study enrolled 26 patients diagnosed with bone metastases. Patients had various primary malignant tumors and tumor lesions in different locations. All patients received MRgFUS for bone metastasis. Each focal spot sonication pulse that was applied to create energy deposition lasted 20 s and was performed at a frequency of 1...
July 18, 2018: Orthopaedic Surgery
Yukari Uemura, Shiro Tanaka, Teruhiko Miyazaki, Mayumi Tsukiyama, Teruki Sone, Akira Taguchi, Satoshi Soen, Satoshi Mori, Hiroshi Hagino, Toshitsugu Sugimoto, Masao Fukunaga, Hiroaki Ohta, Toshitaka Nakamura, Hajime Orimo, Masataka Shiraki
We planned to conduct multi-center, open-labeled, blinded-endpoints, head-to-head randomized trial of minodronate and raloxifene to compare incidences of vertebral and non-vertebral fractures. The study is the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-4). Here, we present the pre-fixed study design. The inclusion criteria are ambulatory older women with osteoporosis, aged > 60 years, and without pre-specified risk factors for secondary osteoporosis and dementia. The subjects who meet selection criteria will be randomly allocated to the raloxifene (60 mg/day) or minodronate (1 mg/day or 50 mg/4 weeks) groups using the central registry...
July 17, 2018: Journal of Bone and Mineral Metabolism
Myeong Seon Kim, Chel-Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Jeeyun Lee, Duk-Soo Bae, Byoung-Gie Kim
Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy...
July 2018: Obstetrics & Gynecology Science
Ashley Davis, Mark P Wilhelm, Timothy J Pendergrass, Dawndra M Sechrist, Jean-Michel Brismée, Phillip S Sizer, Kerry K Gilbert
STUDY DESIGN: Descriptive in situ cadaveric study. INTRODUCTION: Performing accurately directed examination and treatment to the wrist requires clinicians to orient to carpal bone structures. PURPOSE OF THE STUDY: To examine the anatomical relationships that exist within the wrist-hand complex and identify the accuracy of surface anatomy mapping strategies for localizing anatomical landmarks using a palmar approach. METHODS: Twenty-three embalmed cadavers were dissected using standardized procedures...
July 13, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Ran Xue, Qinghua Meng, Juan Li, Jing Wu, Qinwei Yao, Hongwei Yu, Yueke Zhu
Acute-on-chronic liver failure (ACLF) is a serious life-threatening disease with high prevalence. Liver transplantation is the only efficient clinical treatment for ACLF. Because of the rapid progression and lack of liver donors, it is urgent to find an effective and safe therapeutic approach to ACLF. Recent studies showed that multipotent cell transplantation could improve the patients' liver function and enhance their preoperative condition. Cells such as mesenchymal stem cells, bone marrow mononuclear cells and autologous peripheral blood stem cells, which addressed in this study have all been used in multipotent cell transplantation for liver diseases...
June 23, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Erdem Aras Sezgin, O Şahap Atik
Orthobiologics are biologically derived materials which aim to promote healing and regeneration of tissues that are the focus of orthopedic surgery. Since bones, ligaments, tendons, and cartilage have different healing and regeneration characteristics, treatment strategies and clinical problems related to these tissues greatly differ. Although orthobiolgics are an old concept, most of the advancements in this field have been accomplished within the last two decades. A large number of promising laboratory studies show that orthobiolics hold a great potential in launching the next chapter of orthopedics...
August 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
John J Schultz, Michelle M Hawkins, Alexander T Mitchell
Regardless of region, skeletal remains deposited in subaerial contexts are subjected to a progression of taphonomic alterations. However, there are limited postmortem interval (PMI) standards developed, particularly in environments where skeletonization can occur quickly. The research purpose was to evaluate the timing and progression of early weathering alterations in two microenvironments (shaded and open) using pig carcasses (Sus scrofa) in the subtropical humid environment of central Florida. Over nine months, sun bleaching was assessed using Munsell® Soil Color Charts (2009) and scored based on percentage of the bone sun bleached, while bone weathering was further evaluated using Behrensmeyer's (1978) stages...
June 22, 2018: Forensic Science International
Lenka Zátopková, Martin Janík, Petra Urbanová, Jitka Mottlová, Petr Hejna
Laryngohyoid fractures in hanging victims are one of the most studied and paradoxically contradictory topics in forensic pathology. According to literary sources, the incidence of laryngohyoid fractures in hanging varies significantly, from 0% to 100%. To verify the diagnostic significance of these injuries in hanging, we prospectively and consecutively analyzed the occurrence of laryngohyoid fractures in a group of 178 suicidal hanging victims (M/F=150/28, aged 14-94years, mean age=50, complete suspension=111 cases, partial suspension=67 cases) in relation to selected variables (age, sex, weight, the completeness of body suspension, and ligature knot location)...
June 18, 2018: Forensic Science International
Sudip Bhattacharya, Amarjeet Singh
Childhood blindness due to corneal ulceration has historically been prevalent among poor Indian children. To tackle this situation the National Institute of Nutrition (NIN), Hyderabad, India, launched (after field-testing) massive dose based national vitamin A (Vit-A) prophylaxis program. Over a period of time reduction in childhood mortality was also hailed as a beneficial effect of the program. Data from the Indian Council for Medical Research (ICMR) indicate that in most Indian states there has been a gradual reduction in the prevalence of Bitot's spots...
October 2017: Clinical Nutrition ESPEN
Marlijn Hoeks, Marit van der Pol, Rutger Middelburg, Dorothea Evers, Marian van Kraaij, Jaap Jan Zwaginga
OBJECTIVES: Secondary iron overload due to red blood cell transfusions (RBCT) is associated with increased morbidity and mortality. However, attention for secondary iron overload and its side effects in patients with hematological malignancies may need improvement. The aim of this study was to determine the number of transfused RBCT needed to reach a maximum bone marrow iron score (BMIS). METHODS: BMIS was independently assessed by two researchers on consecutive bone marrow samples of 35 acute myeloid leukemia (AML) patients...
July 17, 2018: European Journal of Haematology
Robert Stöhr, Alexander Schuh, Gunnar H Heine, Vincent Brandenburg
Fibroblast growth factor-23 (FGF23) is a mainly osteocytic hormone which increases renal phosphate excretion and reduces calcitriol synthesis. These renal actions are mediated via alpha-klotho as the obligate co-receptor. Beyond these canonical "mineral metabolism" actions, FGF23 has been identified as an independent marker for cardiovascular risk in various patient populations. Previous research has linked elevated FGF23 predominantly to left-ventricular dysfunction and consecutive morbidity and mortality...
2018: Frontiers in Endocrinology
Guojing Luo, Yuedong He, Xijie Yu
The high incidences of bone metastasis in patients with breast cancer, prostate cancer and lung cancer still remains a puzzling issue. The "seeds and soil" hypothesis suggested that bone marrow (soil) may provide a favorable "niche" for tumor cells (seed). When seeking for effective ways to prevent and treat tumor bone metastasis, most researchers focus on tumor cells (seed) but not the bone marrow microenvironment (soil). In reality, only a fraction of circulating tumor cells (CTCs) could survive and colonize in bone...
2018: Frontiers in Endocrinology
Hong Ruan, Youcheng Yu, Xuehua Guo, Qian Jiang, Ying Luo
Background: In this study, simvastatin (SVT) in situ gels were successfully produced by our group. Methods: The preparations were characterized in the following aspects: in vitro gelation, drug release, stability and pharmacodynamics. Results: In this study, drug content of prepared gels was found to be in the range between 89 and 92%. The pH value was in the range between 6.5 and 7.0. The gelation temperature of the prepared thermogelling solutions was 37°C...
2018: Drug Design, Development and Therapy
Hiroaki Tanaka, Toshihiro Miura, Takenori Yamashita, Misao Yoneda, Satoshi Takagi
We evaluated the suitability of Nagoya Shibata Yasuda (NSY) mice as an animal model for examining the influence of a glucose metabolism disorder on bone integrity, using Institute of Cancer Research (ICR) mice as controls. We selected six NSY and ICR mice each that were matched for weight, and measured serum glucose levels, serum insulin levels, and conducted an oral glucose tolerance test. Histological sections of the femurs of both mouse lines were prepared, and the bone strength, mass, and microstructure of the femur were compared, along with bone metabolism...
July 13, 2018: Biological & Pharmaceutical Bulletin
Eric T Rush
BACKGROUND: Hypophosphatasia (HPP) is a rare inborn error of metabolism that results from dysfunction of the tissue non-specific alkaline phosphatase enzyme. Its manifestations are extremely variable, ranging from early lethality to disease limited to the dentition. The disease is life-threatening when manifesting within the first six months of life, excepting the extremely rare benign perinatal hypophosphatasia. Childhood hypophosphatasia, defined as onset of symptoms between six months and eighteen years, can manifest as rickets, pain, decreased mobility, deficits of growth, and fractures...
July 16, 2018: Orphanet Journal of Rare Diseases
Daheui Choi, Jin Chan Park, Ha Na Lee, Ji-Hoi Moon, Hyo-Won Ahn, Kwangyong Park, Jinkee Hong
Chalcone derivatives have been investigated for therapeutic agent such as anticancer, antioxidant and anti-inflammatory fields. In this study, we also have synthesized 4 different type of chalcone derivatives and demonstrated in vitro bioactivities. We divided into 2 groups of chalcones on the basis of similar substituents at aromatic rings and tested cell viability and proliferation potentials, indicating that methoxy substituent on A ring could enhance cytotoxicity and anti-proliferation potential depending on chalcone concentration...
July 16, 2018: Molecular Pharmaceutics
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