keyword
https://read.qxmd.com/read/38390441/b-lines-by-lung-ultrasound-as-a-predictor-of-re-intubation-in-mechanically-ventilated-patients-with-heart-failure
#21
JOURNAL ARTICLE
Junho Hyun, Ah-Ram Kim, Sang Eun Lee, Min-Seok Kim
INTRODUCTION: There have been few studies on predictors of weaning failure from MV in patients with heart failure (HF). We sought to investigate the predictive value of B-lines measured by lung ultrasound (LUS) on the risk of weaning failure from mechanical ventilation (MV) and in-hospital outcomes. METHODS: This was a single-center, prospective observational study that included HF patients who were on invasive MV. LUS was performed immediate before ventilator weaning...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38387810/a-phase-2-randomized-clinical-trial-evaluating-4dct-ventilation-based-functional-lung-avoidance-radiotherapy-for-non-small-cell-lung-cancer
#22
JOURNAL ARTICLE
Andrew M Baschnagel, Mattison J Flakus, Eric M Wallat, Antonia E Wuschner, Richard J Chappell, R Adam Bayliss, Randall J Kimple, Gary E Christensen, Joseph M Reinhardt, Michael F Bassetti, John E Bayouth
PURPOSE: To determine whether 4-dimensional computed tomography (4DCT) ventilation-based functional lung avoidance radiotherapy preserves pulmonary function compared with standard radiotherapy for non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: This single center, randomized, phase 2 trial enrolled patients with NSCLC receiving curative intent radiotherapy with either stereotactic body radiotherapy or conventionally fractionated radiotherapy between 2016 and 2022...
February 20, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38374167/coexistence-of-a-fluid-responsive-state-and-venous-congestion-signals-in-critically-ill-patients-a-multicenter-observational-proof-of-concept-study
#23
MULTICENTER STUDY
Felipe Muñoz, Pablo Born, Mario Bruna, Rodrigo Ulloa, Cecilia González, Valerie Philp, Roberto Mondaca, Juan Pablo Blanco, Emilio Daniel Valenzuela, Jaime Retamal, Francisco Miralles, Pedro D Wendel-Garcia, Gustavo A Ospina-Tascón, Ricardo Castro, Philippe Rola, Jan Bakker, Glenn Hernández, Eduardo Kattan
BACKGROUND: Current recommendations support guiding fluid resuscitation through the assessment of fluid responsiveness. Recently, the concept of fluid tolerance and the prevention of venous congestion (VC) have emerged as relevant aspects to be considered to avoid potentially deleterious side effects of fluid resuscitation. However, there is paucity of data on the relationship of fluid responsiveness and VC. This study aims to compare the prevalence of venous congestion in fluid responsive and fluid unresponsive critically ill patients after intensive care (ICU) admission...
February 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38371066/characteristics-and-outcomes-of-children-with-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-infection-admitted-to-a-quaternary-hospital-a-single-center-experience
#24
JOURNAL ARTICLE
Saleh S Alshehri, Bushra I Minhaji, Mohsina R Pasha, Dina Fouda, Jency Joseph, Nehad Ahmed
Objectives In the setting of the recent global pandemic, children infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causing the coronavirus disease 2019 (COVID-19) presented to our hospital with a variety of symptoms ranging from mild to severe disease including multiorgan dysfunction. Our objective was to study the clinical profile, risk factors, complications, and outcomes in pediatric patients admitted to our center with SARS-CoV-2 infection. Methods This retrospective observational study was conducted at a large quaternary center in Riyadh between May 2020 and September 2021...
January 2024: Curēus
https://read.qxmd.com/read/38369849/pain-trajectories-after-bilateral-orthotopic-lung-transplantation-surgery-performed-via-a-clamshell-incision
#25
JOURNAL ARTICLE
Negmeldeen Mamoun, Morgan A Rosser, Michael Manning, Karthik Raghunathan, Sharon McCartney, Sachin Mehta, Krista Ingle, Brandi Bottiger
INTRODUCTION: The nature, intensity, and progression of acute pain after bilateral orthotopic lung transplantation (BOLT) performed via a clamshell incision has not been well investigated. We aimed to describe acute pain after clamshell incisions using pain trajectories for the study cohort, in addition to stratifying patients into separate pain trajectory groups and investigating their association with donor and recipient perioperative variables. METHODS: After obtaining IRB approval, we retrospectively included all patients ≥18 years old who underwent primary BOLT via clamshell incision at a single center between January 1, 2017, and June 30, 2022...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38365467/perioperative-factors-and-radiographic-severity-scores-for-predicting-the-duration-of-mechanical-ventilation-after-arterial-switch-surgery
#26
JOURNAL ARTICLE
Panop Limratana, Wiriya Maisat, Andy Tsai, Koichi Yuki
OBJECTIVES: Cardiac surgery on cardiopulmonary bypass (CPB) during the neonatal period can cause perioperative organ injuries. The primary aim of this study was to determine the incidence and risk factors associated with postoperative mechanical ventilation duration and acute lung injury after the arterial switch operation (ASO). The secondary aim was to examine the utility of the Brixia score for characterizing postoperative acute lung injury (ALI). DESIGN: A retrospective study...
January 17, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38361987/establishment-of-a-spontaneous-ventilation-anesthesia-model-for-beagle-dogs
#27
JOURNAL ARTICLE
Yuan Zeng, Hui Liu, Fei Cui, Weipeng Cai, Jianxing He, Jun Liu
While spontaneous ventilation (SV) anesthesia is in use for clinical patients, there is still little systematic experimental research into its basic aspects. The rabbit SV model that we established previously has some limitations including the model being too small, differences in anesthetic drugs and anesthesia procedures, so we set out to establish an SV anesthesia model for beagle dogs.•Single lumen tracheal intubation was performed on beagles connecting a ventilator, and the anesthetic dosage was adjusted for spontaneous ventilation before surgery...
June 2024: MethodsX
https://read.qxmd.com/read/38360855/cyclosporine-a-in-hospitalized-covid-19-pneumonia-patients-to-prevent-the-development-of-interstitial-lung-disease-a-pilot-randomized-clinical-trial
#28
JOURNAL ARTICLE
Tatiana Cobo-Ibáñez, Gemma Mora Ortega, Carlos Sánchez-Piedra, Gonzalo Serralta-San Martín, Israel J Thuissard-Vasallo, Vanesa Lores Gutiérrez, Llanos Soler Rangel, Cristina García Yubero, Ana Esteban-Vázquez, Elena López-Aspiroz, Cristina Andreu Vázquez, Inmaculada Toboso, Blanca María Martínez Alonso de Armiño, Rocío Alejandra Olivares Alviso, Rocío Calderón Nieto, Cecilia Yañez, Marlín Alejandra Zakhour González, Tatiana Sainz Sánchez, Silvia Arroyo de la Torre, Nazaret Del Amo Del Arco, Jorge Francisco Gómez-Cerezo, Teresa Ramírez Prieto, Alicia Martínez Hernández, Santiago Muñoz-Fernández
Post-COVID-19 interstitial lung disease (ILD) is a new entity that frequently causes pulmonary fibrosis and can become chronic. We performed a single-center parallel-group open-label pilot randomized clinical trial to investigate the efficacy and safety of cyclosporine A (CsA) in the development of ILD in the medium term among patients hospitalized with COVID-19 pneumonia. Patients were randomized 1:1 to receive CsA plus standard of care or standard of care alone. The primary composite outcome was the percentage of patients without ILD 3 months after diagnosis of pneumonia and not requiring invasive mechanical ventilation (IMV) (response without requiring IMV)...
February 15, 2024: Scientific Reports
https://read.qxmd.com/read/38353403/diaphragm-atrophy-during-invasive-mechanical-ventilation-is-related-to-extubation-failure-in-preterm-infants-an-ultrasound-study
#29
JOURNAL ARTICLE
Stefano Nobile, Annamaria Sbordone, Nicola Salce, Maria Letizia Patti, Alessandro Perri, Simona Fattore, Giorgia Prontera, Lucia Giordano, Milena Tana, Giovanni Vento
BACKGROUND: Diaphragm dysfunction is associated with poor outcomes in critically ill patients. Ventilator-induced diaphragmatic dysfunction (VIDD), including diaphragm atrophy (DA), is poorly studied in newborns. We aimed to assess VIDD and its associations in newborns. METHODS: Single-center prospective study. Diaphragm thickness was measured at end-inspiration (TDI) and end-expiration (TDE) on the right midaxillary line. DA was defined as decrease in TDE ≥ 10%...
February 14, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38351299/the-effect-of-recruitment-maneuvers-on-cerebrovascular-dynamics-and-right-ventricular-function-in-patients-with-acute-brain-injury-a-single-center-prospective-study
#30
JOURNAL ARTICLE
Filippo Sanfilippo, Agnieszka Uryga, Lorenzo Ball, Denise Battaglini, Ida Giorgia Iavarone, Peter Smielewski, Erta Beqiri, Marek Czosnyka, Nicolò Patroniti, Chiara Robba
BACKGROUND: Optimization of ventilatory settings is challenging for patients in the neurointensive care unit, requiring a balance between precise gas exchange control, lung protection, and managing hemodynamic effects of positive pressure ventilation. Although recruitment maneuvers (RMs) may enhance oxygenation, they could also exert profound undesirable systemic impacts. METHODS: The single-center, prospective study investigated the effects of RMs (up-titration of positive end-expiratory pressure) on multimodal neuromonitoring in patients with acute brain injury...
February 13, 2024: Neurocritical Care
https://read.qxmd.com/read/38337547/peep-induced-lung-recruitment-maneuver-combined-with-prone-position-for-ards-a-single-center-prospective-randomized-clinical-trial
#31
JOURNAL ARTICLE
Lan Lan, Yuenan Ni, Yubei Zhou, Linxi Fu, Wentao Wu, Ping Li, He Yu, Guopeng Liang, Fengming Luo
Background: Prone position (PP) and the positive end-expiratory pressure (PEEP)-induced lung recruitment maneuver (LRM) are both efficient in improving oxygenation and prognosis in patients with ARDS. The synergistic effect of PP combined with PEEP-induced LRM in patients with ARDS remains unclear. We aim to explore the effects of PP combined with PEEP-induced LRM on prognosis in patients with moderate to severe ARDS and the predicting role of lung recruitablity. Methods: Patients with moderate to severe ARDS were consecutively enrolled...
February 1, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38333301/clinical-characteristics-and-anaesthetic-management-of-severe-scoliosis-patients-with-spinal-muscular-atrophy-case-series
#32
JOURNAL ARTICLE
Lai Wang, Yi Du, Na Huang, Na Yin, Junming Du, Junlin Yang, Lai Jiang, Yanfei Mao
INTRODUCTION AND IMPORTANCE: There is no expert consensus or guidance on perioperative anaesthesia management for spinal surgery of spinal muscular atrophy (SMA) patients with severe scoliosis (Cobb≧90°). We provide a comprehensive summary of the perioperative characteristics observed in patients with SMA and propose an optimized perioperative management strategy for anaesthesia. METHODS: This study is a retrospective single-centre research. Twenty-six SMA patients with severe scoliosis underwent posterior spinal fusion surgery from September 2019 to September 2022 were enroled...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38327390/intubation-time-lung-mechanics-and-outcome-in-covid-19-patients-suffering-acute-respiratory-distress-syndrome-a-single-center-study
#33
JOURNAL ARTICLE
Diamanto Aretha, Sotiria Kefala, Alexandra Nikolopoulou, Vasilios Karamouzos, Maria Valta, Virginia Mplani, Alexandra Georgakopoulou, Chrysavgi Papamichail, Christina Sklavou, Fotini Fligou
BACKGROUND: We examined the effect of intubation time and the lung mechanics on clinical outcomes in coronavirus disease 2019 (COVID-19) patients. METHODS: Based on the patient's hospital admission, intubation time was defined as early (≤ 2 days) or late (> 2 days). Patients were further divided into three groups; early (≤ 3 days), late (4 - 6 days), and very late (> 6 days) intubated. RESULTS: A total of 194 patients were included; 66...
January 2024: Journal of Clinical Medicine Research
https://read.qxmd.com/read/38316593/pilot-study-of-paediatric-regional-lung-function-assessment-via-x-ray-velocimetry-xv-imaging-in-children-with-normal-lungs-and-in-children-with-cystic-fibrosis
#34
JOURNAL ARTICLE
Matthew Bruorton, Martin Donnelley, Thomas Goddard, Antonia O'Connor, David Parsons, Jessica Phillips, Kristin Carson-Chahhoud, Andrew Tai
INTRODUCTION: Cystic fibrosis (CF) is a life-limiting autosomal recessive genetic condition. It is caused by mutations in the gene that encodes for a chloride and bicarbonate conducting transmembrane channel. X-ray velocimetry (XV) is a novel form of X-ray imaging that can generate lung ventilation data through the breathing cycle. XV technology has been validated in multiple animal models, including the β-ENaC mouse model of CF lung disease. It has since been assessed in early-phase clinical trials in adult human subjects; however, there is a paucity of data in the paediatric cohort, including in CF...
February 5, 2024: BMJ Open
https://read.qxmd.com/read/38314387/surgical-management-of-congenital-pulmonary-airway-malformations-cpam-in-an-infant-and-a-toddler-case-report-depicting-two-distinct-surgical-techniques-with-successful-outcomes
#35
Vishal V Bhende, Tanishq S Sharma, Mathangi Krishnakumar, Deepali M Shah, Rajesh N Pankhaniya, Zalak N Parmar, Alpa M Patel, Dharmendra B Parmar, Amit Kumar, Kartik B Dhami, Sohilkhan R Pathan, Ashwin S Sharma, Vrajana J Parikh, Haryax V Pathak, Rushi B Barot, Dimple B Shah, Swati M Kamani, Nili J Mehta, Gaurav D Bhoraniya, Roshni A Purswani
Congenital pulmonary airway malformations (CPAM) compose the major part of congenital lung malformations (CLM) and have traditionally been treated by pulmonary lobectomy. In terms of surgical strategy, lobectomy has conventionally been the preferred treatment for CPAM localized to a single lobe. More recently, alternative approaches including lung-sparing resections (LSR), such as wedge or non-anatomic resections and segmentectomy, have been suggested. In asymptomatic CPAM early surgical resection is often shown to reduce infection and malignancy development...
February 2024: Curēus
https://read.qxmd.com/read/38309959/-standard-technical-specifications-for-methacholine-chloride-methacholine-bronchial-challenge-test-2023
#36
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38297511/analytical-corrections-for-b-1-inhomogeneity-and-signal-decay-in-multi-slice-2d-spiral-hyperpolarized-129-xe-mri-using-keyhole-reconstruction
#37
JOURNAL ARTICLE
J W Plummer, R Hussain, A S Bdaiwi, M L Costa, M M Willmering, J Parra-Robles, Z I Cleveland, L L Walkup
PURPOSE: Hyperpolarized xenon MRI suffers from heterogeneous coil bias and magnetization decay that obscure pulmonary abnormalities. Non-physiological signal variability can be mitigated by measuring and mapping the nominal flip angle, and by rescaling the images to correct for signal bias and decay. While flip angle maps can be calculated from sequentially acquired images, scan time and breath-hold duration are doubled. Here, we exploit the low-frequency oversampling of 2D-spiral and keyhole reconstruction to measure flip angle maps from a single acquisition...
January 31, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38286417/-prognostic-factors-in-an-individualised-approach-to-non-pharmacological-therapy-of-covid-19-from-oxygen-and-mechanical-ventilation-to-extracorporeal-membrane-oxygenation
#38
JOURNAL ARTICLE
Sandhya Matthes, Johannes Holl, Johannes Randerath, Marcel Treml, Georgios Sofianos, Michael Bockover, Ulrike Oesterlee, Simon Herkenrath, Johannes Knoch, Lars Hagmeyer, Winfried Randerath
BACKGROUND: Our centre followed a stepwise approach in the nonpharmacological treatment of respiratory failure in COVID-19 in accordance with German national guidelines, escalating non-invasive measures before invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO). The aim of this study was to analyse this individualized approach to non-pharmacologic therapy in terms of patient characteristics and clinical features that may help predict more severe disease, particularly the need for intensive care...
January 29, 2024: Pneumologie
https://read.qxmd.com/read/38282310/pulmonary-superinfection-diagnosed-with-bronchoalveolar-lavage-at-intubation-in-covid-patients-a-swedish-single-centre-study
#39
JOURNAL ARTICLE
Fredrik Hammarskjöld, Sören Berg, Herjan Bavelaar, Anna J Henningson, Knut Taxbro
BACKGROUND: Patients with severe coronavirus disease 2019 (COVID) pneumonia and acute respiratory distress syndrome (C-ARDS) on invasive mechanical ventilation (IMV) have been found to be prone to having other microbial findings than severe acute respiratory syndrome coronavirus 2 (SARS-2)-CoV-19 in the bronchoalveolar lavage (BAL) fluid at intubation causing a superinfection. These BAL results could guide empirical antibiotic treatment in complex clinical situations. However, there are limited data on the relationship between microbial findings in the initial BAL at intubation and later ventilator-associated pneumonia (VAP) diagnoses...
January 28, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38276026/fungal-infections-and-colonization-after-bilateral-lung-transplant-a-six-year-single-center-experience
#40
JOURNAL ARTICLE
Annalisa Boscolo, Annamaria Cattelan, Serena Marinello, Francesca Medici, Giovanni Pettenon, Sabrina Congedi, Nicolò Sella, Nicolò Presa, Elisa Pistollato, Stefano Silvestrin, Martina Biscaro, Luisa Muraro, Arianna Peralta, Maria Mazzitelli, Andrea Dell'Amore, Federico Rea, Paolo Navalesi
Fungal infections (FIs) are one of the leading causes of morbidity and mortality within the first year of lung transplant (LT) in LT recipients (LTRs). Their prompt identification and treatment are crucial for a favorable LTR outcome. The objectives of our study were to assess (i) the FI incidence and colonization during the first year after a bilateral LT, (ii) the risk factors associated with FI and colonization, and (iii) the differences in fungal incidence according to the different prophylactic strategies...
January 19, 2024: Journal of Fungi (Basel, Switzerland)
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