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gynecologic researches

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https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-%C3%A2-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#1
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29342108/different-lipid-regulation-in-ovarian-cancer-inhibition-of-the-immune-system
#2
Christina Wefers, Tjitske Duiveman-de Boer, Petra L M Zusterzeel, Leon F A G Massuger, David Fuchs, Ruurd Torensma, Craig E Wheelock, I Jolanda M de Vries
Lipid metabolism is altered in several cancer settings leading to different ratios of intermediates. Ovarian cancer is the most lethal gynecological malignancy. Cancer cells disperse in the abdominal space and ascites occurs. T cells obtained from ascites are unable to proliferate after an antigenic stimulus. The proliferation of ascites-derived T cells can be restored after culturing the cells for ten days in normal culture medium. No pathway aberrancies were detected. The acellular fraction of ascites can inhibit the proliferation of autologous as well as allogeneic peripheral blood lymphocytes, indicating the presence of soluble factors that interfere with T cell functionality...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29331372/cancer-care-delivery-research-in-gynecologic-oncology
#3
EDITORIAL
David I Shalowitz, David E Cohn
No abstract text is available yet for this article.
January 10, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29324544/gestational-trophoblastic-disease-electronic-consults-what-do-patients-and-physicians-want-to-know
#4
Roni Nitecki, Ross S Berkowitz, Kevin M Elias, Donald P Goldstein, Neil S Horowitz
OBJECTIVES: Given the rarity of gestational trophoblastic disease (GTD), specialized regional and national centers for GTD have been established. These centers serve at least 3 purposes: to improve care for women with GTD, to enhance research though collaboration, and to educate other clinicians. This study was undertaken to understand the potential GTD knowledge gap by examining both patient and physician inquiries received at a specialized GTD center. METHODS: All electronic consults received by specialists at our center between March 2016 and March 2017 were analyzed...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29322704/evaluation-of-cerebral-venous-thrombosis-by-ct-mri-and-mr-venography
#5
Pratibha Issar, Sirasapalli Chinna, Sanjeev Kumar Issar
Objective: To study and compare cerebral parenchymal changes and sinuses involvement in CT with MRI and MRV in Cerebral Venous Thrombosis patients. Method: This study was carried out in the Department of Radiodiagnosis, JLN Hospital and Research Center, Bhilai, Chhattisgarh from October 2012 to Nov 2014 and includes fifty patients of all age groups presenting with clinical symptoms of CVT, admitted in Neurology, Neurosurgery, Medicine, Pediatric, obstetric and Gynecology wards...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29322213/translation-and-validation-of-the-international-consultation-on-incontinence-questionnaire-vaginal-symptoms-iciq-vs-the-danish-version
#6
Louise Thomsen Schmidt Arenholt, Marianne Glavind-Kristensen, Henrik Bøggild, Karin Glavind
INTRODUCTION: In the clinical evaluation of women with pelvic organ prolapse (POP), it is important to evaluate both objective and subjective presentations. The objective evaluation is done by gynecological examination, but the subjective presentation is more complex. The International Consultation on Incontinence Questionnaire-Vaginal Symptoms (ICIQ-VS) is an important tool for subjective evaluation, and a Danish version was developed. MATERIALS AND METHODS: The English version was translated into Danish in accordance with guidelines...
January 10, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29318118/evaluation-of-the-health-related-behaviour-of-pregnant-women-from-warsaw-poland
#7
Dariusz Boguszewski, Jakub Grzegorz Adamczyk, Wiesław Tomaszewski, Daria Sałata, Ewelina Skowera, Marta Patalon, Anna Obszyńska-Litwiniec, Dariusz Białoszewski
Background: Pregnancy is a period of time when women tend to suffer from the weakening of their psychophysical fitness. This research evaluated several selected elements of the lifestyle of pregnant women compared to those of non-pregnant women. Methods: Overall, 482 women attended to the Childbirth School in Gynecological-Obstetric Hospital "Inflancka" in Warsaw, Poland, in the years 2011-2013; Group 1 contained 214 pregnant, and Group 2 contained 268 non-pregnant completed a survey inquiry...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29313498/the-delegation-of-tasks-in-the-era-of-e-health-to-support-community-interventions-in-maternal-and-child-health-lessons-learned-from-the-pact-denbaya-project
#8
C-O Bagayoko, M Niang, A Anne, D Traoré, H Sangho, A-K Traoré, A Geissbuhler
The PACT-Denbaya project (Program for community access to telemedicine for families) aimed to help improve the health of mothers and child in rural communities through the delegation of obstetric-gynecologic and pediatric tasks, supported by teleconsultations. This operational research took place in 6 community health centers in the Dioïla health district in Mali. Our method was based of the delegation of tasks, supported by teleconsultations. Experts in pediatrics and obstetrics/gynecology provided a week-long training program to general practitioners and midwives, in the management of the most common problems in the field and in the use of the "Bogou" teleconsultation and "Dudal" tele-education platforms to ensure exchanges and follow-up...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29304796/referral-gynecological-ambulatory-clinic-principal-diagnosis-and-distribution-in-health-services
#9
Adna Thaysa Marcial da Silva, Camila Lohmann Menezes, Edige Felipe de Sousa Santos, Paulo Francisco Ramos Margarido, José Maria Soares, Edmund Chada Baracat, Luiz Carlos de Abreu, Isabel Cristina Esposito Sorpreso
BACKGROUND: The association between gynecological diagnoses and their distribution in the health sectors provides benefits in the field of women's health promotion and in medical and interdisciplinary education, along with rationalization according to level of care complexity. Thus, the objective is analyze the clinical-demographic characteristics, main diagnoses in gynecological ambulatory care, and their distribution in health services. METHOD: This is a research project of retrospective audit study design with a chart review of data from 428 women treated at University Ambulatory Clinic of Women's Health, the facility in gynecology and training for Family and Community Medical Residents, São Paulo, Brazil, from 2012 to 2014...
January 5, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29304240/adipose-tissue-derived-stem-cells-in-a-fibrin-implant-enhance-neovascularization-in-a-peritoneal-grafting-site-a-potential-way-to-improve-ovarian-tissue-transplantation
#10
D D Manavella, L Cacciottola, C M Desmet, B F Jordan, J Donnez, C A Amorim, M M Dolmans
STUDY QUESTION: Do two different concentrations of human adipose tissue-derived stem cells (ASCs) embedded inside a fibrin scaffold have the potential to differentiate into vessels and aid vascularization in a peritoneal grafting site intended for ovarian tissue transplantation? SUMMARY ANSWER: Human ASCs in low and high concentrations differentiated into vessels when transplanted to mouse peritoneum inside a fibrin matrix, but only high ASC concentrations significantly increased human vessel area 14 days after transplantation...
January 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29303934/calcification-a-disregarded-or-ignored-issue-in-the-gynecologic-tumor-microenvironments
#11
Jirui Wen, Yali Miao, Shichao Wang, Ruijie Tong, Zhiwei Zhao, Jiang Wu
Although calcification in the gynecologic tumor microenvironments is a common phenomenon, doctors and researchers still disregard or ignore the issue. In fact, this change in the gynecologic tumor microenvironments is clinically significant and a number of studies have reported an association between calcification and gynecological tumor progression. In ovarian cancer, calcification is predominantly psammomatous and largely occurs in serous papillary ovarian tumors. In addition, calcification in ovarian cancer correlated with lower histologic grade and may indicate a poorer survival rate...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29298821/physiological-and-pathological-implications-of-retinoid-action-in-the-endometrium
#12
Yanwen Jiang, Lu Chen, Robert Taylor, Chunjin Li, Xu Zhou
Retinol (vitamin A) and its derivatives, collectively known as retinoids, are required for maintaining vision, immunity, barrier function, reproduction, embryogenesis, and cell proliferation and differentiation. Despite the fact that most events in the endometrium are predominantly regulated by steroid hormones (estrogens and progesterone), accumulating evidence shows that retinoid signaling is also involved in the development and maintenance of the endometrium, stromal decidualization, and blastocyst implantation...
January 3, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29294986/individual-and-institutional-predictors-of-ipv-sv-screening-in-college-health-centers
#13
Melissa A Sutherland, Heidi Collins Fantasia, M Katherine Hutchinson, Jennifer Katz
Intimate partner violence (IPV) and sexual violence (SV) are significant public health issues for women, particularly for college women. IPV and SV have been associated with numerous adverse health consequences and involvement in unhealthy behaviors. Given the health risks and high rates of IPV/SV among college women, it is important to understand and promote screening in this population. The purpose of this study was to examine college women's experiences with IPV/SV screening at college health centers and identify individual and institutional characteristics associated with screening...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29286461/ultrasonography-in-experimental-reproductive-investigations-on-rats
#14
Tianjuang Wang, Lidia Oltra-Rodríguez, Nuria García-Carrillo, Anibal Nieto, Yunxia Cao, María L Sánchez-Ferrer
With the development of assisted reproductive technology and the ethical limitations of research on humans, rat animal models have been widely used in reproductive medicine. In the past, the study of reproductive system development in rodents has been based on one-time histological examination of excised tissues. Recently, with the development of high-resolution transabdominal ultrasound, high-quality sonography can now be performed to evaluate the reproductive organs of rats, allowing a new method for studying the reproductive system...
December 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29282582/rural-urban-differences-in-surgical-treatment-regional-lymph-node-examination-and-survival-in-endometrial-cancer-patients
#15
Whitney E Zahnd, Katherine S Hyon, Paula Diaz-Sylvester, Sonya R Izadi, Graham A Colditz, Laurent Brard
PURPOSE: Endometrial cancer (EC) is the most common gynecological malignancy and one of few cancers with an increasing US mortality rate. Rural patients may have less access to specialty care affecting their receipt of surgery and adequate lymphadenectomy (AL). We sought to assess rural-urban differences in EC surgery, lymphadenectomy, and survival. METHODS: We analyzed data from the Surveillance Epidemiology and End Results database on EC patients (2004-2013). We performed univariate analyses to compare rural and urban patients on demographic and clinical characteristics and receipt of nodal examination and AL...
December 27, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29278598/research-summaries-the-11th-biennial-rivkin-center-ovarian-cancer-research-symposium
#16
Deborah K Armstrong
In September 2016, the 11th biennial ovarian cancer research symposium was presented by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research. The 2016 symposium focused on 4 broad areas of research: Mechanisms of Initiation and Progression of Ovarian Cancer, Tumor Microenvironment and Models of Ovarian Cancer, Detection and Prevention of Ovarian Cancer, and Novel Therapeutics for Ovarian Cancer. The presentations and abstracts from each of these areas are reviewed in this supplement to the International Journal of Gynecologic Oncology...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29277039/the-development-and-validation-of-a-new-postpartum-sexual-function-and-dyspareunia-assessment-tool-the-carol-scale
#17
Carolina López-Lapeyrere, Noelia Serna-Gómez, Ana Belén Hernández-López, María Francisca Pérez-García, Ana Tejeda-Esteban, Montserrat Solís-Muñoz
OBJECTIVE: The aim is to develop a new tool to evaluate postpartum sexual function and dyspareunia which will facilitate better evaluation of perineal pain in woman after vaginal delivery. DESIGN: The development and validation of the Carol Postpartum Sexual Function and Dyspareunia Assessment Scale. SETTING: The Obstetrics and Gynecology Service of a University Hospital in central Spain. PARTICIPANTS: 102 women after being attended for vaginal birth, and 5 midwife assessors...
December 6, 2017: Midwifery
https://www.readbyqxmd.com/read/29260313/post-operative-cognitive-decline-pocd-after-gynaecologic-surgery-current-opinions-and-future-applications
#18
Zarbo Cristina, Brivio Michela, Brugnera Agostino, Malandrino Chiara, Trezzi Gaetano, Rabboni Massimo, Bondi Emi, Compare Angelo, Frigerio Luigi
OBJECTIVE: Postoperative cognitive decline (POCD) is known to occur quite frequently after a cardiac surgery, especially in older population. Few studies specifically focused on its incidence and characteristics in gynecological setting. METHODS: Current opinions and future applications of POCD studies in gynecological setting have been discussed. RESULT: There are still many questions and issues about POCD in gynecological setting that remain unanswered as well as numerous research fields that have not been still explored...
December 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29258459/-once-the-delivery-is-done-they-have-finished-a-qualitative-study-of-perspectives-on-postnatal-care-referrals-by-traditional-birth-attendants-in-ebonyi-state-nigeria
#19
Adanna Chukwuma, Chinyere Mbachu, Jessica Cohen, Thomas Bossert, Margaret McConnell
BACKGROUND: While 79% of Nigerian mothers who deliver in facilities receive postnatal care within 48 h of delivery, this is only true for 16% of mothers who deliver outside facilities. Most maternal deaths can be prevented with access to timely and competent health care. Thus, the World Health Organization, International Confederation of Midwives, and International Federation of Gynecology and Obstetrics recommend that unskilled birth attendants be involved in advocacy for skilled care use among mothers...
December 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29251679/morcellation-in-gynecologic-oncology
#20
Eva Chalas
PURPOSE OF REVIEW: Morcellation of uteri with unsuspected malignancies has been the focus of reports for decades. More intensive evaluation of clinical outcomes and evaluation of impact of changes in practice has occurred since the release of FDA statement advising against the use of power morcellators. The review summarizes some of the most relevant publications on this topic. RECENT FINDINGS: The Society of Gynecologic Oncology and the American College of Obstetricians and Gynecologists concur that symptomatic women should undergo appropriate evaluation, morcellation should not be performed whenever malignancy is suspected or diagnosed, and acknowledge the limitations of diagnostic testing currently available to detect leiomyosarcoma...
February 2018: Current Opinion in Obstetrics & Gynecology
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