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https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#1
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28919554/revisiting-the-wandering-womb-oxytocin-in-endometriosis-and-bipolar-disorder
#2
REVIEW
Natalie L Dinsdale, Bernard J Crespi
Hippocrates attributed women's high emotionality - hysteria - to a 'wandering womb'. Although hysteria diagnoses were abandoned along with the notion that displaced wombs cause emotional disturbance, recent research suggests that elevated levels of oxytocin occur in both bipolar disorder and endometriosis, a gynecological condition involving migration of endometrial tissue beyond the uterus. We propose and evaluate the hypothesis that elevated oxytocinergic system activity jointly contributes to bipolar disorder and endometriosis...
September 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#3
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28905985/it-is-time-for-routine-screening-for-perinatal-mood-and-anxiety-disorders-in-obstetrics-and-gynecology-settings
#4
Eynav Elgavish Accortt, Melissa S Wong
Importance: Women are 2 to 3 times more likely than men to experience depression in their lifetime, and the greatest risk occurs during the reproductive years. As an obstetrics and gynecology physician or provider, you will likely encounter women who are at risk of development or relapse of a mental disorder during this vulnerable time. Objective: The aim of this review is to examine theory and research on mood and anxiety disorders during the perinatal period with an emphasis on screening recommendations...
September 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28904542/claims-about-medical-malpractices-resulting-in-maternal-and-perinatal-mortality-referred-to-iranian-legal-medicine-organization-during-2011-2012
#5
Ziba Taghizadeh, Maryam Pourbakhtiar, Masoud Ghadipasha, Kamran Soltani, Khadijeh Azimi
BACKGROUND: Obstetricians, gynecologists, and midwives are the most common specialists of the medical sciences group against whom medical malpractices are claimed, many of which are avoidable and preventable. Therefore, the present study was conducted to investigate the causes of claims regarding medical malpractices resulting in maternal and perinatal mortality. MATERIALS AND METHODS: A descriptive cross-sectional study was conducted and 7616 claims of medical malpractices in the field of obstetrics, gynecology, and midwifery that were referred from all 31 provinces to the central commission of legal medicine were studied during 2011-2012...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28901313/microrna-30c-inhibits-metastasis-of-ovarian-cancer-by-targeting-metastasis-associated-gene-1
#6
Xia Wang, Li-Wei Qiu, Chen Peng, Shu-Ping Zhong, Lin Ye, Di Wang
BACKGROUND: It is important to find reliable molecular markers or biological targets that associate with ovarian cancer (OC) metastasis for diagnosis and treatment. In this study, researchers investigated the regulated chain of microRNA-30c (miR-30c) and metastasis-associated gene 1 (MTA1) in OC tissues and cells. MATERIALS AND METHODS: Expression of miR-30c and MTA1 was detected with quantitative real-time polymerase chain reaction and immunohistochemistry in 33 OC and matched adjacent tissues...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28888701/direct-mass-spectrometry-differentiation-of-ectopic-and-eutopic-endometrium-in-patients-with-endometriosis
#7
Leila Adamyan, Natalia Starodubtseva, Anna Borisova, Assia Stepanian, Vitaliy Chagovets, Dinara Salimova, Zhihao Wang, Alexey Kononikhin, Igor Popov, Anna Bugrova, Konstantin Chingin, Andrey Kozachenko, Huanwen Chen, Vladimir Frankevich
STUDY OBJECTIVE: To introduce a method for rapid assessment of endometriotic tissues using direct mass spectrometry (MS)-based lipidomics. DESIGN: Prospective observational cohort study. DESIGN CLASSIFICATION: II 2. SETTING: Department of Operative Gynecology of the Research Centre for Obstetrics, Gynecology and Perinatology. PATIENTS: Fifty patients with ovarian cysts and peritoneal endometriosis who underwent laparoscopic surgery between 2014 and 2016...
September 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28885424/creating-flexible-and-sustainable-work-models-for-academic-obstetrician-gynecologists-engaged-in-global-health-work
#8
Rose Molina, Adeline Boatin, Huma Farid, Rebecca Luckett, Dayna Neo, Hope Ricciotti, Jennifer Scott
OBJECTIVE: To describe various work models for obstetrics and gynecology global health faculty affiliated with academic medical centers and to identify barriers and opportunities for pursuing global health work. METHODS: A mixed-methods study was conducted in 2016 among obstetrics and gynecology faculty and leaders from seven academic medical institutions in Boston, Massachusetts. Global health faculty members were invited to complete an online survey about their work models and to participate in semistructured interviews about barriers and facilitators of these models...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28885409/a-plea-for-mersqi-the-medical-education-research-study-quality-instrument
#9
Roger P Smith, Lee A Learman
OBJECTIVE: To describe the quality of educational scholarship presented at a large national conference of obstetrics and gynecology educators. METHODS: We reviewed Council on Resident Education in Obstetrics and Gynecology-Association of Professors of Gynecology and Obstetrics annual meeting abstracts from 2015 and 2016, published as supplements to Obstetrics & Gynecology. For this uncontrolled observational study, abstracts were reviewed and scored using the Medical Education Research Study Quality Instrument (MERSQI)...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28876309/use-of-patient-delivered-partner-therapy-in-us-college-settings-associations-with-legality-perceived-legality-and-other-sexual-and-reproductive-health-services
#10
Matthew Hogben, Alexandra Caccamo, Oscar Beltran, Ryan Cramer, Melissa A Habel
BACKGROUND: Young adults, including college students, have higher rates of chlamydia than the general population. Patient-delivered partner therapy (PDPT) is a partner treatment option for sex partners of individuals diagnosed with chlamydia or gonorrhea. We examined college health center use of PDPT in a national sample of colleges. METHODS: During 2014 to 2015, we collected data from 482 colleges and universities (55% of 885 surveyed), weighting responses by institutional characteristics abstracted from a national database (eg, 2-year vs 4-year status)...
June 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28874936/factors-influencing-participation-in-clinical-trials-emergency-medicine-vs-other-specialties
#11
Anita Kurt, Hope M Kincaid, Charity Curtis, Lauren Semler, Matthew Meyers, Melanie Johnson, Beth A Careyva, Brian Stello, Timothy J Friel, Mark C Knouse, John C Smulian, Jeanne L Jacoby
INTRODUCTION: This study investigated factors that influence emergency medicine (EM) patients' decisions to participate in clinical trials and whether the impact of these factors differs from those of other medical specialties. METHODS: A survey was distributed in EM, family medicine (FM), infectious disease (ID), and obstetrics/gynecology (OB/GYN) outpatient waiting areas. Eligibility criteria included those who were 18 years of age or older, active patients on the day of the survey, and able to complete the survey without assistance...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28872976/serum-il-6-and-il-8-correlate-with-prognostic-factors-in-ovarian-cancer
#12
Marcela Moisés Maluf Sanguinete, Paula Honório De Oliveira, Agrimaldo Martins-Filho, Douglas Côbo Micheli, Beatriz Martins Tavares-Murta, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini
The aim of the study was to correlate serum levels of IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α with clinical, laboratory, and pathological prognostic factors in patients with primary ovarian malignancy. Patients treated at the Pelvic Mass Ambulatory of the Discipline of Gynecology and Obstetrics/Oncology Research Institute (IPON) of the UFTM with confirmed diagnosis of malignant ovarian neoplasia (n = 26) were evaluated. Serum collection was performed preoperatively for the determination of tumor markers...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28871018/early-life-exposure-to-air-pollutants-and-adverse-pregnancy-outcomes-protocol-for-a-prospective-cohort-study-in-beijing
#13
Jing Song, Yi Chen, Ling Wei, Ying Ma, Ning Tian, Shi Yun Huang, Yin Mei Dai, Li Hong Zhao, Yuan Yuan Kong
INTRODUCTION: The association between early exposure to ambient air pollution and adverse pregnancy outcomes in China is unclear. This study will assess the risk of early-life exposure to air pollutants in Beijing and explore the viability of 8-hydroxydeoxyguanosine (8-OHdG) as a biological indicator to assess oxidative stress induced by early-life exposure to air pollution. METHODS AND ANALYSIS: Here, 2500 women with singleton pregnancies and their infants will be recruited from the Beijing Obstetrics and Gynecology Hospital...
September 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28869032/tissue-engineering-as-an-adjunct-to-pelvic-reconstructive-surgery
#14
Hanna Jangö
This PhD-thesis is based on animal studies and comprises three original papers and unpublished data. The studies were con-ducted during my employment as a research fellow at the Department of Obstetrics and Gynecology, Herlev University Hospital, Denmark. New strategies for surgical reconstruction of pelvic organ pro-lapse (POP) are warranted. Traditional native tissue repair may be associated with poor long-term outcome and augmentation with permanent polypropylene meshes is associated with frequent and severe adverse effects...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28862221/pelvic-radiotherapy-does-not-deteriorate-the-quality-of-life-of-women-with-gynecologic-cancers-in-long-term-follow-up-a-2-years-prospective-single-center-study
#15
Guler Yavas, Cagdas Yavas, Nasuh Utku Dogan, Tolgay Tuyan Ilhan, Selen Dogan, Pinar Karabagli, Ozlem Ata, Ebru Yuce, Cetin Celik
PURPOSE: To evaluate the emotional, sexual and health-related quality of life (HRQoL) concerns of the women with gynecologic malignancy treated with curative radiotherapy (RT). PATIENTS AND METHODS: A 100 women with diagnosis of gynecologic malignancy were prospectively enrolled. HRQoL at baseline, at the end of RT and during follow-up was assessed using European Organization for Research and Treatment of Cancer QoL Questionnaire-C30 (EORTC QLQ-C30), EORTC QLQ-cervical cancer module 24, and Hospital Anxiety and Depression Scale...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28861459/development-of-a-comprehensive-and-sustainable-gynecologic-oncology-training-program-in-western-kenya-a-low-resource-setting
#16
Barry Rosen, Peter Itsura, Philip Tonui, Alan Covens, Luc van Lonkhuijzen, Elkanah Omenge Orang'o
To provide information on the development of a gynecologic oncology training program in a low-resource setting in Kenya. This is a review of a collaboration between Kenyan and North American physicians who worked together to develop a gynecologic oncology training in Kenya. We review the published data on the increase of cancer incidence in sub-Saharan Africa and outline the steps that were taken to develop this program. The incidence of cervical cancer in Kenya is very high and is the leading cause of cancer mortality in Kenya...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28859920/sponsoring-surgeons-an-investigation-on-the-influence-of-the-da-vinci-robot
#17
Cory N Criss, Samir K Gadepalli
INTRODUCTION: The integrity of the medical literature about robotic surgery remains unclear despite wide-spread adoption. We sought to determine if payment from Intuitive Surgical Incorporated (ISI) affected quality of the research produced by surgeons. METHODS: Publicly available financial data from the CMS website regarding the top-20 earners from ISI for 2015 was gathered. Studies conducted by these surgeons were identified using PubMed. Inclusion criteria consisted of publications about the da Vinci(®) robot on patient outcomes...
August 26, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28854581/unexplained-recurrent-miscarriages-are-associated-with-an-aberrant-sperm-protamine-mrna-content
#18
Nina Rogenhofer, Johannes Ott, Adrian Pilatz, Julia Wolf, Christian J Thaler, Lisa Windischbauer, Undraga Schagdarsurengin, Klaus Steger, Viktoria von Schönfeldt
STUDY QUESTION: Are unexplained recurrent miscarriages associated with abnormal protamine-1 and protamine-2 mRNA levels in spermatozoa? SUMMARY ANSWER: Both protamine-1 and protamine-2 mRNA levels as well as the protamine-1 to protamine-2 mRNA ratio in spermatozoa from men whose female partners experienced two or more consecutive miscarriages were significantly different compared to those from both healthy control men and subfertile couples undergoing IVF/ICSI. WHAT IS KNOWN ALREADY: Aberrant sperm protamine ratios are known to be associated with male-factor infertility...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28852657/a-content-analysis-of-pediatric-information-in-widely-circulated-newspapers-in-iran
#19
Firoozeh Zare-Farashbandi, Faezeh Amini, Alireza Rahimi, Roya Kelishadi
BACKGROUND: Newspapers play an important role in improving public health literacy. This study analysis the content of pediatric information in widely circulated Iranian newspapers in 2014. MATERIALS AND METHODS: This is an applied survey performed using content analysis method. The data gathering tool was a checklist designed by the researcher. The sample size was determined using nonprobability sampling to be 426 articles with pediatric-related topics of five Iranian newspapers...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28851349/the-utilization-of-traditional-chinese-medicine-in-patients-with-dysfunctional-uterine-bleeding-in-taiwan-a-nationwide-population-based-study
#20
Yi-Rong Lin, Mei-Yao Wu, Jen-Huai Chiang, Hung-Rong Yen, Su-Tso Yang
BACKGROUND: Many patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan. METHODS: We analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626...
August 29, 2017: BMC Complementary and Alternative Medicine
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