Lea L Backhausen, Jonas Granzow, Juliane H Fröhner, Eric Artiges, Marie-Laure Paillère-Martinot, Hervé Lemaître, Fabio Sticca, Tobias Banaschewski, Sylvane Desrivières, Antoine Grigis, Andreas Heinz, Rüdiger Brühl, Dimitri Papadopoulos-Orfanos, Luise Poustka, Sarah Hohmann, Lauren Robinson, Henrik Walter, Jeanne Winterer, Gunter Schumann, Jean-Luc Martinot, Michael N Smolka, Nora C Vetter
BACKGROUND: Early negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence...
March 2024: JCPP Adv