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https://www.readbyqxmd.com/read/28525836/arterial-spin-labelling-shows-functional-depression-of-non-lesion-tissue-in-chronic-wernicke-s-aphasia
#1
Holly Robson, Karsten Specht, Helen Beaumont, Laura M Parkes, Karen Sage, Matthew A Lambon Ralph, Roland Zahn
Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow (CBF) is rarely investigated in chronic stroke. This study investigated CBF in individuals with chronic Wernicke's aphasia (WA) and examined the relationship between lesion, CBF and neuropsychological impairment. Arterial spin labelling CBF imaging and structural MRIs were collected in 12 individuals with chronic WA and 13 age-matched control participants...
November 10, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28512508/lhermitte-duclos-disease-and-cerebellar-gangliocytoma-an-incidental-finding-in-a-patient-with-gradual-vision-loss
#2
Akshay Badakere, Pratik Chaugule, Soveeta Souravee Rath
A 50-year-old male patient presented to the neuro-ophthalmology clinic with chief complaints of gradual decrease in vision in both eyes, more in the left eye, for 6 years. On general examination, the patient had a hemiplegic gait. His presenting acuity was 20/50 in the right eye and 20/320 in the left eye, not improving further. He had dense posterior subcapsular cataracts in both eyes, and fundus examination revealed pale discs. Humphrey visual field tests 30-2 revealed a vertical nasal midline defect in the right eye and grossly depressed fields in the left eye...
June 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28505996/depression-one-year-after-hemorrhagic-stroke-is-associated-with-late-worsening-of%C3%A2-outcomes
#3
Sara Stern-Nezer, Irina Eyngorn, Michael Mlynash, Ryan W Snider, Chitra Venkatsubramanian, Christine A C Wijman, Marion S Buckwalter
BACKGROUND: Poststroke depression is the most common psychiatric sequelae of stroke, and it's independently associated with increased morbidity and mortality. Few studies have examined depression after intracranial hemorrhage (ICH). OBJECTIVE: To investigate the relationship between depression, ICH and outcomes. METHODS: A substudy of the prospective Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study, we included 89 subjects assessed for depression 1 year after hemorrhage...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28504840/clinical-utility-of-a-short-resting-state-mri-scan-in-differentiating-bipolar-from-unipolar-depression
#4
M Li, T Das, W Deng, Q Wang, Y Li, L Zhao, X Ma, Y Wang, H Yu, X Li, Y Meng, L Palaniyappan, T Li
OBJECTIVE: Depression in bipolar disorder (BipD) requires a therapeutic approach that is from treating unipolar major depressive disorder (UniD), but to date, no reliable methods could separate these two disorders. The aim of this study was to establish the clinical validity and utility of a non-invasive functional MRI-based method to classify BipD from UniD. METHOD: The degree of connectivity (degree centrality or DC) of every small unit (voxel) with every other unit of the brain was estimated in 22 patients with BipD and 22 age, gender, and depressive severity-matched patients with UniD and 22 healthy controls...
May 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28503674/identifying-brain-nociceptive-information-transmission-in-patients-with-chronic-somatic-pain
#5
Don A Davis, Mariam E Ghantous, Melissa A Farmer, Alexis T Baria, A Vania Apkarian
INTRODUCTION: Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from site of injury-related parameters. These results compel revisiting the role of peripheral nociceptive signaling in chronic pain. We address this issue by examining what brain circuitry transmit information regarding the intensity of chronic pain and how this information may be related to a common co-morbidity, depression...
October 2016: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28501680/dilated-virchow-robin-spaces-in-the-hippocampus-impact-behaviors-and-effects-of-anti-depressant-treatment-in-model-of-depressed-rats
#6
Yuefeng Li, Jinchuan Yan, Xiaolan Zhu, Yan Zhu, Shun Yao, Yuhao Xu, Shenghong Ju
The occurrences of dilated Virchow-Robin spaces (dVRSs) and inflammatory factors were closely related with development of depression and antidepressants. The present study indicated accumulation of inflammatory factors in dVRSs played a practical role in behaviors and the treatment-resistant in rats with depression. Eighty-one male Wistar rats were exposed to chronic unpredictable mild stress (CUMS) until the model was successfully established. According to the detection of dVRSs on 7 T structural magnetic resonance imaging (MRI), rats were divided into two groups (45 CUMS(non-dVRSs) rats and 36 CUMS(dVRSs) rats)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28494346/glutamatergic-and-neural-dysfunction-in-postpartum-depression-using-magnetic-resonance-spectroscopy
#7
Carlos E Rosa, Jair C Soares, Felipe P Figueiredo, Ricardo C Cavalli, Marco A Barbieri, Maristela S Schaufelberger, Carlos E G Salmon, Cristina M Del-Ben, Antonio C Santos
Although postpartum depression (PPD) is a prevalent subtype of major depressive disorder, neuroimaging studies on PPD are rare, particularly those identifying neurochemical abnormalities obtained by proton magnetic resonance spectroscopy (¹H-MRS). The dorsolateral prefrontal (DLPF) and the anterior cingulate gyrus (ACG) are part of the neural pathways involved in executive functions and emotional processing, and both structures have been implicated in the neurobiology of depressive disorders. This study aimed to evaluate brain metabolites abnormalities in women with PPD compared with healthy postpartum (HP) women...
April 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28493898/apathy-but-not-depression-is-associated-with-executive-dysfunction-in-cerebral-small-vessel-disease
#8
Valerie Lohner, Rebecca L Brookes, Matthew J Hollocks, Robin G Morris, Hugh S Markus
OBJECTIVE: To determine the prevalence of apathy and depression in cerebral small vessel disease (SVD), and the relationships between both apathy and depression with cognition. To examine whether apathy is specifically related to impairment in executive functioning and processing speed. METHODS: 196 patients with a clinical lacunar stroke and an anatomically corresponding lacunar infarct on MRI were compared to 300 stroke-free controls. Apathy and depression were measured using the Geriatric Depression Scale, and cognitive functioning was assessed using an SVD cognitive screening tool, the Brief Memory and Executive Test, which measures executive functioning/processing speed and memory/orientation...
2017: PloS One
https://www.readbyqxmd.com/read/28487648/regional-brain-volumes-moderate-but-do-not-mediate-the-effects-of-group-based-exercise-training-on-reductions-in-loneliness-in-older-adults
#9
Diane K Ehlers, Ana M Daugherty, Agnieszka Z Burzynska, Jason Fanning, Elizabeth A Awick, Laura Chaddock-Heyman, Arthur F Kramer, Edward McAuley
Introduction: Despite the prevalence of and negative health consequences associated with perceived loneliness in older adults, few studies have examined interactions among behavioral, psychosocial, and neural mechanisms. Research suggests that physical activity and improvements in perceived social support and stress are related to reductions in loneliness. Yet, the influence of brain structure on these changes is unknown. The present study examined whether change in regional brain volume mediated the effects of changes in social support and stress on change in perceived loneliness after an exercise intervention...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28479531/-structural-brain-development-in-healthy-children-and-adolescents
#10
Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki
Brain maturation progresses throughout childhood into adolescence. Investigating the mechanism of brain development during these periods in healthy people is necessary for some clinical purposes. For example, these mechanisms are needed to investigate the mechanism of impaired brain maturation in neurodevelopmental disorders-such as autism spectrum disorders or attention-deficit hyper disorder-and improve early prevention of psychiatric or neurodegenerative diseases like depression or Alzheimer's disease. Voxel-based morphometry (VBM) is an effective way to analyze brain magnetic resonance images (MRI) of children and adolescents, as the brain structures of children and adolescents vary widely depending on their age, sex, and several other factors...
May 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28469157/brain-iron-chelation-by-deferiprone-in-a-phase-2-randomised-double-blinded-placebo-controlled-clinical-trial-in-parkinson-s-disease
#11
Antonio Martin-Bastida, Roberta J Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R Crichton, David T Dexter
Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomology. In a randomised double-blind, placebo controlled trial, 22 early onset PD patients, were administered deferiprone, 10 or 15 mg/kg BID or placebo, for 6 months. Patients were evaluated for PD severity, cognitive function, depression rating and quality of life...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28458697/myocardial-iron-load-measured-by-cardiac-magnetic-resonance-imaging-to-evaluate-cardiac-systolic-function-in-thalassemia
#12
Masoumeh Kahnooji, Hamid Reza Rashidinejad, Mohammad Shahram Yazdanpanah, Nahid Azdaki, Ahmad Naghibzadeh-Tahami
BACKGROUND: The assessment of cardiac iron overload in thalassemia major has been considered as an important predictive factor of heart injury. The magnetic resonance imaging (MRI)-derived relaxation time parameter (T2*) varies inversely with iron level, and elevated myocardial iron levels by T2* are associated with depressed left ventricular (LV) ejection fraction (EF). We compared echocardiographic (ECHO) indices of systolic function to myocardial T2* in these patients. METHODS: A cross-sectional database review identified 200 consecutive patients with thalassemia who underwent both ECHO and MRI T2* assessment...
September 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28457809/circulating-inflammatory-biomarkers-in-relation-to-brain-structural-measurements-in-a-non-demented-elderly-population
#13
Yian Gu, Robert Vorburger, Nikolaos Scarmeas, José A Luchsinger, Jennifer J Manly, Nicole Schupf, Richard Mayeux, Adam M Brickman
The aim of this investigation was to determine whether circulating inflammatory biomarkers c-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to structural brain measures assessed by magnetic resonance imaging (MRI). High-resolution structural MRI was collected on 680 non-demented elderly (mean age 80.1years) participants of a community-based, multiethnic cohort. Approximately three quarters of these participants also had peripheral inflammatory biomarkers (CRP, IL6, and ACT) measured using ELISA...
April 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28452647/a-case-of-fronto-temporal-dementia-ftd-masquerading-as-mood-disorder
#14
Sarah Pospos, Min Xi, Guanjie Chen, Ruiguo Zhang, Qingrong Tan, Andrius Baskys
A 56-year old Chinese female was referred to an academic medical center with atypical, treatment-resistant depression that continued for approximately 3 years after her sister's death. Comprehensive evaluation including neurocognitive testing, EEG, spinal tap, HIV testing and brain MRI revealed behavioral variant of fronto-temporal dementia (bvFTD) with significant frontal and temporal lobe atrophy.This patient's unusual clinical presentation emphasizes the overlap between depression and bvFTD, and underlines the importance of prompt, accurate diagnosis to minimize often-ineffective pharmacological interventions and caregiver burnout...
December 23, 2016: Clinical Gerontologist
https://www.readbyqxmd.com/read/28450069/circulating-steroids-negatively-correlate-with-tinnitus
#15
Pavel Chrbolka, Zoltán Palúch, Martin Hill, Štefan Alušík
While not a disease entity in itself; symptoms of tinnitus (from Latin tinnio - clink) accompany a number of diseases. Tinnitus prevalence increases with age, deteriorates one's quality of life, and may even result in suicidal behavior. Tinnitus develops in response to a variety of risk factors, otoxic substances, noise exposure, hearing disorders, and psychological alterations. Tinnitus is closely related to mood, depression, and psychological state. In the present study, we focused on alterations of the steroid metabolome and particularly neuroactive, neuroprotective, and immunomodulatory steroids in patients with tinnitus...
April 25, 2017: Steroids
https://www.readbyqxmd.com/read/28446218/increased-galectin-3-may-serve-as-a-serologic-signature-of-pre-rheumatoid-arthritis-while-markers-of-synovitis-and-cartilage-do-not-differ-between-early-undifferentiated-arthritis-subsets
#16
Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M Lindegaard, Jakob M Møller, Peter Junker
BACKGROUND: Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. METHODS: One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR)...
April 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28445740/right-brain-left-brain-in-depressive-disorders-clinical-and-theoretical-implications-of-behavioral-electrophysiological-and-neuroimaging-findings
#17
REVIEW
Gerard E Bruder, Jonathan W Stewart, Patrick J McGrath
The right and left side of the brain are asymmetric in anatomy and function. We review electrophysiological (EEG and event-related potential), behavioral (dichotic and visual perceptual asymmetry), and neuroimaging (PET, MRI, NIRS) evidence of right-left asymmetry in depressive disorders. Recent electrophysiological and fMRI studies of emotional processing have provided new evidence of altered laterality in depressive disorders. EEG alpha asymmetry and neuroimaging findings at rest and during cognitive or emotional tasks are consistent with reduced left prefrontal activity in depressed patients, which may impair downregulation of amygdala response to negative emotional information...
April 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28443058/predicting-outcome-12-months-after-mild-traumatic-brain-injury-in-patients-admitted-to-a-neurosurgery-service
#18
Torgeir Hellstrøm, Tobias Kaufmann, Nada Andelic, Helene L Soberg, Solrun Sigurdardottir, Eirik Helseth, Ole A Andreassen, Lars T Westlye
OBJECTIVE: Accurate outcome prediction models for patients with mild traumatic brain injury (MTBI) are key for prognostic assessment and clinical decision-making. Using multivariate machine learning, we tested the unique and added predictive value of (1) magnetic resonance imaging (MRI)-based brain morphometric and volumetric characterization at 4-week postinjury and (2) demographic, preinjury, injury-related, and postinjury variables on 12-month outcomes, including global functioning level, postconcussion symptoms, and mental health in patients with MTBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28442954/evaluation-of-efficacy-of-dexmedetomidine-versus-propofol-for-sedation-in-children-undergoing-magnetic-resonance-imaging
#19
Kirti Kamal, Unnati Asthana, Teena Bansal, Jagdish Dureja, Geeta Ahlawat, Saloni Kapoor
BACKGROUND: A deep level of sedation is required for magnetic resonance imaging (MRI) in children to ensure optimum image quality. The present study was conducted to evaluate the efficacy and safety of dexmedetomidine versus propofol for sedation in children undergoing MRI. MATERIALS AND METHODS: A total of sixty children aged 2-10 years, having physical status 1 or 2 according to the American Society of Anesthesiologists, undergoing MRI were included in the study...
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28434675/cadasil-as-a-useful-medical-model-and-genetic-form-of-vascular-depression
#20
Joon Hyuk Park, Bong-Hee Jeon, Jung Seok Lee, Paul A Newhouse, Warren D Taylor, Brian D Boyd, Ki Woong Kim, Moon-Doo Kim
OBJECTIVE: The main magnetic resonance imaging (MRI) findings of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are white matter hyperintensities (WMHs), lacunar infarctions, and cerebral microbleeds (CMBs). The purpose of this study was to investigate the effects of these three neuroimaging markers of CADASIL on depression to determine whether CADASIL is a useful medical model supporting the vascular depression hypothesis. METHODS: Eighty-four subjects with CADASIL, aged 34-86 years, participated in this study...
March 23, 2017: American Journal of Geriatric Psychiatry
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