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https://www.readbyqxmd.com/read/29136110/meta-connectomic-analysis-reveals-commonly-disrupted-functional-architectures-in-network-modules-and-connectors-across-brain-disorders
#1
Zhiqiang Sha, Mingrui Xia, Qixiang Lin, Miao Cao, Yanqing Tang, Ke Xu, Haiqing Song, Zhiqun Wang, Fei Wang, Peter T Fox, Alan C Evans, Yong He
Neuropsychiatric disorders are increasingly conceptualized as disconnection syndromes that are associated with abnormal network integrity in the brain. However, whether different neuropsychiatric disorders show commonly dysfunctional connectivity architectures in large-scale brain networks remains largely unknown. Here, we performed a meta-connectomic study to identify disorder-related functional modules and brain regions by combining meta-analyses of 182 published resting-state functional MRI studies in 11 neuropsychiatric disorders and graph-theoretical analyses of 3 independent resting-state functional MRI datasets with healthy and diseased populations (Alzheimer's disease and major depressive disorder [MDD])...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29133948/increased-hippocampal-tail-volume-predicts-depression-status-and-remission-to-anti-depressant-medications-in-major-depression
#2
J J Maller, K Broadhouse, A J Rush, E Gordon, S Koslow, S M Grieve
Studies of patients with major depressive disorder (MDD) have consistently reported reduced hippocampal volumes; however, the exact pattern of these volume changes in specific anatomical subfields and their functional significance is unclear. We sought to clarify the relationship between hippocampal tail volumes and (i) a diagnosis of MDD, and (ii) clinical remission to anti-depressant medications (ADMs). Outpatients with nonpsychotic MDD (n=202) based on DSM-IV criteria and a 17-item Hamilton Rating Scale for Depression (HRSD17) score ⩾16 underwent pretreatment magnetic resonance imaging as part of the international Study to Predict Optimized Treatment for Depression (iSPOT-D)...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29132998/waiting-for-radiology-test-results-patient%C3%A2-expectations-and-emotional-disutility
#3
Sean Woolen, Ella A Kazerooni, Amber Wall, Kelly Parent, Shannon Cahalan, Mitchell Alameddine, Matthew S Davenport
PURPOSE: To measure patient willingness to wait and emotional disutility of waiting for outpatient imaging test results. METHODS: A prospective HIPAA-compliant multicenter outpatient quality improvement survey was administered by a trained interviewer to 218 outpatients from November 1, 2016, to February 1, 2017. The survey was vetted by patient- and family-centered care advocates with experience in survey design and underwent precognitive testing for readability...
November 9, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29130510/heterogenous-migraine-aura-symptoms-correlate-with-visual-cortex-fmri-responses
#4
Nanna Arngrim, Anders Hougaard, Khazar Ahmadi, Mark Bitsch Vestergaard, Henrik Winther Schytz, Faisal Mohammad Amin, Henrik Bo Wiberg Larsson, Jes Olesen, Michael B Hoffmann, Messoud Ashina
OBJECTIVE: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. METHODS: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham or physical exercise and photostimulation...
November 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29129723/neural-correlates-of-impaired-self-regulation-in-male-youths-with-autism-spectrum-disorder-a-voxel-based-morphometry-study
#5
Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7-17years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist>180. There were 53 and 28 boys in the ASD+Dysregulation and ASD-Dysregulation groups, respectively...
November 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128327/clinical-predictors-of-stroke-mimics-in-patients-treated-with-recombinant-tissue-plasminogen-activator-according-to-a-normal-multimodal-computed-tomography-imaging
#6
Stephane Olindo, Martin Chardonnet, Pauline Renou, Cyrielle Coignion, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, François Rouanet, Igor Sibon
BACKGROUND: Multimodal computed tomography imaging (MCTI) is increasingly used for rapid assessment of acute stroke. We investigated characteristics and final diagnoses of patients treated with recombinant tissue plasminogen activator (rt-PA) while admission imaging was unremarkable. METHODS: From our prospectively collected stroke database (2013-2016), we identified consecutive patients treated with rt-PA on the basis of an unremarkable brain MCTI and assessed with a 24-hour follow-up brain magnetic resonance imaging (MRI)...
November 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29118724/alternations-of-white-matter-structural-networks-in-first-episode-untreated-major-depressive-disorder-with-short-duration
#7
Yi Lu, Zonglin Shen, Yuqi Cheng, Hui Yang, Bo He, Yue Xie, Liang Wen, Zhenguang Zhang, Xuejin Sun, Wei Zhao, Xiufeng Xu, Dan Han
It is crucial to explore the pathogenesis of major depressive disorder (MDD) at the early stage for the better diagnostic and treatment strategies. It was suggested that MDD might be involving in functional or structural alternations at the brain network level. However, at the onset of MDD, whether the whole brain white matter (WM) alterations at network level are already evident still remains unclear. In the present study, diffusion MRI scanning was adopt to depict the unique WM structural network topology across the entire brain at the early stage of MDD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29111383/disturbed-glutathione-antioxidative-defense-is-associated-with-structural-brain-changes-in-neuroleptic-na%C3%A3-ve-first-episode-psychosis-patients
#8
K Langbein, J Hesse, A Gussew, B Milleit, S Lavoie, G P Amminger, C Gaser, G Wagner, J R Reichenbach, U-C Hipler, D Winter, S Smesny
BACKGROUND: Oxidative stress and impaired antioxidant defense are reported in schizophrenia and are thought to be associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, negative symptomatology, and cognitive impairment. To test some of these assumptions we investigated the glutathione (GSH) antioxidant defense system (AODS) and brain structural abnormalities in drug-naïve individuals with first acute episode of psychosis (FEP). METHOD: The study involved 27 drug-naïve FEP patients and 31 healthy controls (HC)...
October 18, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29107830/magnetic-resonance-imaging-of-the-human-locus-coeruleus-a-systematic-review
#9
REVIEW
Kathy Y Liu, Freya Marijatta, Dorothea Hämmerer, Julio Acosta-Cabronero, Emrah Düzel, Robert J Howard
The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, innervates extensive areas throughout the brain and is implicated in a variety of autonomic and cognitive functions. Alterations in the LC-noradrenergic system have been associated with healthy ageing and neuropsychiatric disorders including Parkinson's disease, Alzheimer's disease and depression. The last decade has seen advances in imaging the structure and function of the LC, and this paper systematically reviews the methodology and outcomes of sixty-nine structural and functional MRI studies of the LC in humans...
October 28, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29100658/the-role-of-genes-and-environment-on-brain-alterations-in-major-depressive-disorder-a-review-of-twin-studies
#10
A Pigoni, G Delvecchio, A C Altamura, J C Soares, C Fagnani, P Brambilla
BACKGROUND: Although it has been consistently reported the important role of genetic and environmental risk factors on structural and functional alterations in Major Depressive Disorder (MDD), the mechanism and the magnitude of the interactions between specific genetic and/or environmental risk factors on brain structures in this disabling disorder are still elusive. Therefore, in the last two decades an increased interest has been devoted to neuroimaging investigations on monozygotic and dizygotic twin samples mainly because their intrinsic characteristics may help to separate the effects of genetic and environmental risk factors on clinical phenotypes, including MDD...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29100305/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#11
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#12
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29089886/depression-and-dementia-in-old-old-population-history-of-depression-may-be-associated-with-dementia-onset-the-tome-project
#13
Yi-Chien Liu, Kenichi Meguro, Kei Nakamura, Kyoko Akanuma, Masahiro Nakatsuka, Takashi Seki, Shutaro Nakaaki, Masaru Mimura, Norito Kawakami
Background: In this study, we investigated the relationship among a history of depression, depressive states, and dementia in a community-based old-old cohort. Methods: From 2012 to 2013, we recruited 200 subjects residing in Tome, Japan. Ultimately, 181 subjects were enrolled in our study and completed the whole study protocol. We used the World Mental Health-Composite International Diagnostic Interview 3.0 to evaluate whether subjects had a history of depression or other affective disorders. Simultaneously, 3...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29080235/cortical-thickness-alterations-linked-to-somatoform-and-psychological-dissociation-in-functional-neurological-disorders
#14
David L Perez, Nassim Matin, Benjamin Williams, Kaloyan Tanev, Nikos Makris, W Curt LaFrance, Bradford C Dickerson
BACKGROUND: Links between dissociation and functional neurological disorder (FND)/conversion disorder are well-established, yet the pathophysiology of dissociation remains poorly understood. This MRI study investigated structural alterations associated with somatoform and psychological dissociation in FND. We hypothesized that multimodal, paralimbic cingulo-insular regions would relate to the severity of somatoform dissociation in patients with FND. METHODS: FreeSurfer cortical thickness and subcortical volumetric analyses were performed in 26 patients with motor FND and 27 matched healthy controls...
October 28, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29079433/other-race-effect-on-amygdala-response-during-affective-facial-processing-in-major-depression
#15
Anjali Sankar, Sergi G Costafreda, Lauren B Marangell, Cynthia H Y Fu
OBJECTIVE: The other race effect, also known as own race bias, refers to the enhanced ability to recognize faces belonging to one's own race relative to faces from another race. The other race effect is associated with increased amygdala response in healthy individuals. The amygdala is a key node in emotion processing which shows impaired functioning in depression and has been proposed to be a marker of depressive state. We investigated the impact of the other race effect on amygdala responses in depression...
October 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29079138/a-homer-1-gene-variant-influences-brain-structure-and-function-lithium-effects-on-white-matter-and-antidepressant-response-in-bipolar-disorder-a-multimodal-genetic-imaging-study
#16
Francesco Benedetti, Sara Poletti, Clara Locatelli, Elena Mazza, Cristina Lorenzi, Alice Vitali, Martina Riberto, Silvia Brioschi, Benedetta Vai, Irene Bollettini, Elisa Melloni, Veronica Aggio, Andrea Falini, Andrea De Bartolomeis, Cristina Colombo
BACKGROUND: The Homer family of postsynaptic scaffolding proteins plays a crucial role in glutamate-mediated synaptic plasticity, a phenotype associated with Bipolar Disorder (BD). Homer is a target for antidepressants and mood stabilizers. The AA risk genotype of the Homer rs7713917 A>G SNP has been associated with mood disorders and suicide, and in healthy humans with brain function. Despite the evidence linking Homer 1 gene and function to mood disorder, as well as its involvement in animal models of depression, no study has yet investigated the role of Homer in bipolar depression and treatment response...
October 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29075837/an-open-label-study-to-assess-the-feasibility-and-tolerability-of-rilmenidine-for-the-treatment-of-huntington-s-disease
#17
Benjamin R Underwood, Zeyn W Green-Thompson, Peter J Pugh, Stanley E Lazic, Sarah L Mason, Jules Griffin, P Simon Jones, James B Rowe, David C Rubinsztein, Roger A Barker
Preclinical data have shown that rilmenidine can regulate autophagy in models of Huntington's disease (HD), providing a potential route to alter the disease course in patients. Consequently, a 2-year open-label study examining the tolerability and feasibility of rilmenidine in mild-moderate HD was undertaken. 18 non-demented patients with mild to moderate HD took daily doses of 1 mg Rilmenidine for 6 months and 2 mg for a further 18 months followed by a 3-month washout period. The primary outcome was the number of withdrawals and serious adverse events...
October 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29075345/factors-that-influence-the-severity-of-post-stroke-depression
#18
S Ilut, A Stan, A Blesneag, V Vacaras, S Vesa, L Fodoreanu
AIM: The aim of this paper was to investigate whether the extent of neurological impairment, the location of ischemic lesions due to stroke are associated with the severity of post-stroke depression. MATERIALS AND METHODS: The study included 82 patients, who were diagnosed with acute ischemic stroke and post-stroke depression and were admitted to the Neurology Clinic of Cluj-Napoca County Emergency Hospital between 2009 and 2011. A head MRI was performed with a 1...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29069932/lumbar-intravertebral-disc-herniation-secondary-to-idiopathic-calcific-discitis
#19
Ahmed-Ramadan Sadek, Christopher Dare, Stephen McGillion, Ali Nader-Sepahi, Vasileios Skiadas
Calcific discitis is a well recognized entity in the paediatric population but more recently has been increasingly reported in adults. It typically involves the lower thoracic vertebrae and is of unknown aetiology. Herniation of the calcified fragment is rare but typically occurs out through the annulus fibrosus into the canal space. Herein we describe the first reported case of calcific discitis involving the lumbar vertebrae with subsequent herniation of the calcified disc into and through the anterior aspect of the L5 vertebra...
October 26, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29065364/effects-of-behavioral-activation-on-default-mode-network-connectivity-in-subthreshold-depression-a-preliminary-resting-state-fmri-study
#20
Satoshi Yokoyama, Yasumasa Okamoto, Koki Takagaki, Go Okada, Masahiro Takamura, Asako Mori, Syouichi Shiota, Naho Ichikawa, Ran Jinnin, Shigeto Yamawaki
BACKGROUND: Subthreshold depression is a risk factor for major depressive disorder, and it is known to have a negative impact on quality of life (QOL). Although behavioral activation, which is one type of cognitive behavioral therapy, is an effective psychological intervention for subthreshold depression, neural mechanisms of behavioral activation are unclear. Enhanced functional connectivity between default mode network (DMN) and the other regions has been demonstrated in participants with subthreshold depression...
October 7, 2017: Journal of Affective Disorders
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