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https://www.readbyqxmd.com/read/28790831/spontaneous-alterations-of-regional-brain-activity-in-patients-with-adult-generalized-anxiety-disorder
#1
Likun Xia, Shumei Li, Tianyue Wang, Yaping Guo, Lihong Meng, Yunping Feng, Yu Cui, Fan Wang, Jian Ma, Guihua Jiang
OBJECTIVE: We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD). PATIENTS AND METHODS: Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample t-test on the voxel-based analysis of the regional homogeneity (ReHo) maps...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28780181/white-matter-tract-alterations-in-parkinson-s-disease-patients-with-punding
#2
Elisa Canu, Federica Agosta, Vladana Markovic, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess brain white matter tract alterations in patients with Parkinson's disease and punding (PD-punding) compared with controls and PD cases without any impulsive-compulsive behaviour. METHODS: Forty-nine PD patients (21 PD-punding and 28 PD with no impulsive-compulsive behaviours) and 28 controls were consecutively recruited. Clinical, cognitive and psychopathological evaluations were performed. Diffusion tensor MRI metrics of the main white matter tracts were assessed using a tractography approach...
July 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#3
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28770292/cortical-bridging-venous-segment-protruding-into-the-inner-skull-depression-a-potential-site-of-hemorrhage-at-external-ventriculostomy
#4
Satoshi Tsutsumi, Hideo Ono, Yukimasa Yasumoto
PURPOSE: The cortical bridging venous segment protruding into the inner skull depression (CBVISD), a distinctive structure found in the calvarial convexity, may be a potential risk factor for hemorrhagic complications resulting from trephination. However, this subject has not been documented. In the present study, we explore the CBVISD using magnetic resonance imaging (MRI). METHODS: A total of 94 patients underwent contrast-enhanced MRI. Distributions of the CBVISDs were recorded in two symmetrical regions of the frontal calvarial convexity...
August 2, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28764994/alexithymia-in-multiple-sclerosis-a-systematic-review-of-literature
#5
REVIEW
Moussa A Chalah, Samar S Ayache
BACKGROUND: Alexithymia is a multidimensional personality construct characterized by difficulties identifying and describing one's feelings, and externally oriented thinking. Although extensively reported in psychiatric patients, little attention has been paid regarding its occurrence and its pathophysiology in the context of multiple sclerosis (MS). METHODS: A research was conducted according to the PRISMA guidelines aiming to identify original research articles in English and French languages about alexithymia in MS...
July 29, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28736515/heidelberg-neuro-music-therapy-enhances-task-negative-activity-in-tinnitus-patients
#6
Christoph M Krick, Heike Argstatter, Miriam Grapp, Peter K Plinkert, Wolfgang Reith
Background: Suffering from tinnitus causes mental distress in most patients. Recent findings point toward a diminished activity of the brain's default-mode network (DMN) in subjects with mental disorders including depression or anxiety and also recently in subjects with tinnitus-related distress. We recently developed a therapeutic intervention, namely the Heidelberg Neuro-Music Therapy (HNMT), which shows an effective reduction of tinnitus-related distress following a 1-week short-term treatment. This approach offers the possibility to evaluate the neural changes associated with the improvements in tinnitus distress...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28735700/sex-differences-in-the-relationship-between-conduct-disorder-and-cortical-structure-in%C3%A2-adolescents
#7
Areti Smaragdi, Harriet Cornwell, Nicola Toschi, Roberta Riccelli, Karen Gonzalez-Madruga, Amy Wells, Roberta Clanton, Rosalind Baker, Jack Rogers, Nayra Martin-Key, Ignazio Puzzo, Molly Batchelor, Justina Sidlauskaite, Anka Bernhard, Anne Martinelli, Gregor Kohls, Kerstin Konrad, Sarah Baumann, Nora Raschle, Christina Stadler, Christine Freitag, Edmund J S Sonuga-Barke, Stephane De Brito, Graeme Fairchild
OBJECTIVE: Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such sex differences extend to cortical and subcortical structure. METHOD: As part of a European multisite study (FemNAT-CD), structural magnetic resonance imaging (MRI) data were collected from 48 female and 48 male participants with CD and from 104 sex-, age-, and pubertal-status-matched controls (14-18 years of age)...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#8
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28727718/quantity-of-disc-removal-and-radiological-outcomes-of-percutaneous-endoscopic-lumbar-discectomy
#9
Ji Han Heo, Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Young-Geun Seo, Dong Hoi Kim, Sung Bae Park, Jung Hyeon Moon, Won Heo, Jong-Myung Jung
BACKGROUND: Herniated intervertebral disc disease (HIVD) is a common cause of lower back and leg pain. Percutaneous endoscopic lumbar discectomy (PELD) is indicated when non-surgical treatments such as medication and interventions are intractable. Ruptured discs and loose fragments inside discs are removed during PELD. Nerve root decompression is usually assessed by visualizing the free movement of the traversing nerve root or epidural fat, the free passage of a probe into the epidural space, the depression of the annulus, and the removal of the expected ruptured discs and loose fragments based on preoperative magnetic resonance images (MRI)...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28715552/large-perivascular-spaces-visible-on-magnetic-resonance-imaging-cerebral-small-vessel-disease-progression-and-risk-of-dementia-the-age-gene-environment-susceptibility-reykjavik-study
#10
Jie Ding, Sigurður Sigurðsson, Pálmi V Jónsson, Gudny Eiriksdottir, Andreas Charidimou, Oscar L Lopez, Mark A van Buchem, Vilmundur Guðnason, Lenore J Launer
Importance: With advancing age, an increased visibility of perivascular spaces (PVSs) on magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of interstitial fluid from the brain and may reflect underlying cerebral small vessel disease (SVD). However, whether large perivascular spaces (L-PVSs) (>3 mm in diameter) visible on MRI are associated with SVD and cognitive deterioration in older individuals is unknown. Objective: To examine whether L-PVSs are associated with the progression of the established MRI markers of SVD, cognitive decline, and increased risk of dementia...
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28704802/trajectories-of-depressive-symptoms-and-their-relationship-to-the-progression-of-dementia
#11
Maria Lage Barca, Karin Persson, Rannveig Eldholm, Jūratė Šaltytė Benth, Hege Kersten, Anne-Brita Knapskog, Ingvild Saltvedt, Geir Selbaek, Knut Engedal
BACKGROUND: The relationship between progression of Alzheimer's disease and depression and its underlying mechanisms has scarcely been studied. METHODS: A sample of 282 outpatients with Alzheimer's disease (AD; 105 with amnestic AD and 177 with Alzheimer's dementia) from Norway were followed up for an average of two years. Assessment included Cornell Scale for Depression in Dementia and Clinical Dementia Rating Scale (CDR) at baseline and follow-up to examine the relationship between AD and depression...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28700672/prediction-of-clinical-depression-scores-and-detection-of-changes-in-whole-brain-using-resting-state-functional-mri-data-with-partial-least-squares-regression
#12
Kosuke Yoshida, Yu Shimizu, Junichiro Yoshimoto, Masahiro Takamura, Go Okada, Yasumasa Okamoto, Shigeto Yamawaki, Kenji Doya
In diagnostic applications of statistical machine learning methods to brain imaging data, common problems include data high-dimensionality and co-linearity, which often cause over-fitting and instability. To overcome these problems, we applied partial least squares (PLS) regression to resting-state functional magnetic resonance imaging (rs-fMRI) data, creating a low-dimensional representation that relates symptoms to brain activity and that predicts clinical measures. Our experimental results, based upon data from clinically depressed patients and healthy controls, demonstrated that PLS and its kernel variants provided significantly better prediction of clinical measures than ordinary linear regression...
2017: PloS One
https://www.readbyqxmd.com/read/28694044/more-randomized-and-resilient-in-the-topological-properties-of-functional-brain-networks-in-patients-with-major-depressive-disorder
#13
Huaizhou Li, Haiyan Zhou, Yang Yang, Haiyuan Wang, Ning Zhong
Previous studies have reported the enhanced randomization of functional brain networks in patients with major depressive disorder (MDD). However, little is known about the changes of key nodal attributes for randomization, the resilience of network, and the clinical significance of the alterations. In this study, we collected the resting-state functional MRI data from 19 MDD patients and 19 healthy control (HC) individuals. Graph theory analysis showed that decreases were found in the small-worldness, clustering coefficient, local efficiency, and characteristic path length (i...
July 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28691530/depressive-symptoms-in-parkinson-s-disease-are-related-to-decreased-left-hippocampal-volume-correlation-with-the-15-item-shortened-version-of-the-geriatric-depression-scale
#14
Masami Goto, Koji Kamagata, Taku Hatano, Nobutaka Hattori, Osamu Abe, Shigeki Aoki, Masaaki Hori, Tsutomu Gomi
Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson's disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28690225/-grey-matter-concentration-revealed-by-voxel-based-morphometry-in-individuals-with-cognitive-vulnerability-to-depression
#15
Shuwen Yuan, Hui Lei, Shuqiao Yao, Xiaocui Zhang
To explore the grey matter concentration in individuals with cognitive vulnerability to depression.
 Methods: Thirty individuals with cognitive vulnerability to depression and thirty age- and gender-matched healthy controls were enrolled in this study, and they were subjected to magnetic resonance imaging (MRI) examination. The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI.
 Results: Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular, left cerebellum, right supplementary motor area, and left precentral gyrus than those in the healthy controls, while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus, right middle frontal gyrus, and left cuneus than those in the individuals with cognitive vulnerability to depression...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28688824/white-matter-lesions-are-associated-with-specific-depressive-symptom-trajectories-among-incident-depression-and-dementia-populations-three-city-dijon-mri-study
#16
Phillip J Tully, Stephanie Debette, Bernard Mazoyer, Christophe Tzourio
OBJECTIVE: Evidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia. METHODS: In this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age: 72 years; 59...
July 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28681749/bilateral-anterior-capsulotomy-for-patients-with-refractory-obsessive-compulsive-disorder-a-multicenter-long-term-follow-up-study
#17
Hong Bin Liu, Qi Zhong, Wei Wang
OBJECTIVE: The objectives of this retrospective study were to analyze the short-term and long-term effects and complications of stereotactic anterior capsulotomy for patients with refractory obsessive-compulsive disorder (OCD). The advantages and disadvantages of stereotactic anterior capsulotomy have been discussed. MATERIALS AND METHODS: Between October 2007 and June 2010, 37 patients with OCD underwent anterior capsulotomy in West China Hospital of Sichuan University or Mian Yang Central Hospital...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28674759/impaired-sensory-processing-measured-by-functional-mri-in-bipolar-disorder-manic-and-depressed-mood-states
#18
Joseph J Shaffer, Casey P Johnson, Jess G Fiedorowicz, Gary E Christensen, John A Wemmie, Vincent A Magnotta
Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we compare functional magnetic resonance imaging (fMRI) responses during a flashing checkerboard stimulus between bipolar participants across mood states (euthymia, depression, and mania) in order to identify functional differences between these states...
July 3, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28672181/corpus-callosum-macro-and-microstructure-in-late-life-depression
#19
Louise Emsell, Christopher Adamson, François-Laurent De Winter, Thibo Billiet, Daan Christiaens, Filip Bouckaert, Katarzyna Adamczuk, Rik Vandenberghe, Marc L Seal, Pascal Sienaert, Stefan Sunaert, Mathieu Vandenbulcke
BACKGROUND: Differences in corpus callosum (CC) morphology and microstructure have been implicated in late-life depression and may distinguish between late and early-onset forms of the illness. However, a multimodal approach using complementary imaging techniques is required to disentangle microstructural alterations from macrostructural partial volume effects. METHODS: 107 older adults were assessed: 55 currently-depressed patients without dementia and 52 controls without cognitive impairment...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28671125/distribution-of-types-of-dementia-in-the-first-100-patients-seen-at-a-dementia-clinic-in-india
#20
Vijay Chandra, Veer Singh Mehta
The aim of our study was to determine if the distribution of types of dementia could explain the reported lower prevalence of dementia in India. The study is an observational study of the first 100 cases of dementia. All patients were evaluated clinically and with blood tests and MRI of the brain. The causes of dementia were: Lewy body dementia (22%), depression (20%), Alzheimer's disease (13%), and mild cognitive impairment (18%). Other dementias were less common. The distribution of dementia types in this series is different from that reported globally...
2017: Journal of Alzheimer's Disease: JAD
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