keyword
https://read.qxmd.com/read/38492550/trait-anxiety-is-associated-with-attentional-brain-networks
#1
JOURNAL ARTICLE
Víctor De la Peña-Arteaga, Pamela Chavarría-Elizondo, Asier Juaneda-Seguí, Ignacio Martínez-Zalacaín, Pedro Morgado, José Manuel Menchón, Maria Picó-Pérez, Miquel A Fullana, Carles Soriano-Mas
Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a large sample (n = 179) of individuals who completed the trait and state versions of the State-Trait Anxiety Inventory and underwent resting-state functional magnetic resonance imaging. We used independent component analysis to characterize individual resting-state networks (RSNs), and multiple regression analyses to assess the relationship between trait anxiety and intrinsic connectivity...
March 15, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38487076/alzheimer-s-disease-heterogeneity-revealed-by-neuroanatomical-normative-modeling
#2
JOURNAL ARTICLE
Flavia Loreto, Serena Verdi, Seyed Mostafa Kia, Aleksandar Duvnjak, Haneen Hakeem, Anna Fitzgerald, Neva Patel, Johan Lilja, Zarni Win, Richard Perry, Andre F Marquand, James H Cole, Paresh Malhotra
INTRODUCTION: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD-related atrophy. METHODS: We applied neuroanatomical normative modeling to magnetic resonance imaging from a real-world clinical cohort with confirmed AD ( n  = 86). Regional cortical thickness was compared to a healthy reference cohort ( n  = 33,072) and the number of outlying regions was summed (total outlier count) and mapped at individual- and group-levels...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38486954/interplay-of-early-negative-life-events-development-of-orbitofrontal-cortical-thickness-and-depression-in-young-adulthood
#3
JOURNAL ARTICLE
Lea L Backhausen, Jonas Granzow, Juliane H Fröhner, Eric Artiges, Marie-Laure Paillère-Martinot, Hervé Lemaître, Fabio Sticca, Tobias Banaschewski, Sylvane Desrivières, Antoine Grigis, Andreas Heinz, Rüdiger Brühl, Dimitri Papadopoulos-Orfanos, Luise Poustka, Sarah Hohmann, Lauren Robinson, Henrik Walter, Jeanne Winterer, Gunter Schumann, Jean-Luc Martinot, Michael N Smolka, Nora C Vetter
BACKGROUND: Early negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence...
March 2024: JCPP Adv
https://read.qxmd.com/read/38485934/preliminary-evidence-for-preserved-synaptic-density-in-late-life-depression
#4
JOURNAL ARTICLE
Thomas Vande Casteele, Maarten Laroy, Margot Van Cauwenberge, Michel Koole, Patrick Dupont, Stefan Sunaert, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo PET findings in early-onset depression and Alzheimer's Disease suggest that synaptic deficits contribute to the pathophysiology of these disorders and may therefore contribute to lower gray matter volume in late-life depression. Here, we investigate synaptic density in vivo for the first time in late-life depression using the synaptic vesicle glycoprotein 2A receptor radioligand 11 C-UCB-J...
March 14, 2024: Translational Psychiatry
https://read.qxmd.com/read/38484877/reduced-coupling-between-global-signal-and-cerebrospinal-fluid-inflow-in-patients-with-depressive-disorder-a-resting-state-functional-mri-study
#5
JOURNAL ARTICLE
Yanyu Zhang, Bo Peng, Shengli Chen, Qunjun Liang, Yingli Zhang, Shiwei Lin, Ziyun Xu, Jiayun Zhang, Gangqiang Hou, Yingwei Qiu
BACKGROUND: Depressed patients often suffer from sleep disturbance, which has been recognized to be responsible for glymphatic dysfunction. The purpose of this study was to investigate the coupling strength of global blood‑oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics, which is a biomarker for glymphatic function, in depressed patients and to explore its potential relationship with sleep disturbance by using resting-state functional MRI. METHODS: A total of 138 depressed patients (112 females, age: 34...
March 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38484532/alterations-of-the-amplitude-of-low-frequency-fluctuation-induced-by-repetitive-transcranial-magnetic-stimulation-combined-with-antidepressants-treatment-for-major-depressive-disorder
#6
JOURNAL ARTICLE
Jing Qiu, Weiguo Gu, Yuan Zhang, Lei Wang, Junkang Shen
We investigated the neuroimaging changes and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants in major depressive disorder (MDD) patients. We scanned 35 patients with MDD and 27 healthy controls (HC) with resting-state functional magnetic resonance imaging (fMRI) before and after treatment. We analyzed amplitude of low-frequency fluctuation (ALFF) and the correlation with clinical variables. The rate of significant efficacy after treatment was higher in the combination treatment group than in the antidepressant group, although not statistically significant...
March 13, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38483760/amygdala-volume-is-associated-with-adhd-risk-and-severity-beyond-comorbidities-in-adolescents-clinical-testing-of-brain-chart-reference-standards
#7
JOURNAL ARTICLE
Ádám Nárai, Petra Hermann, Alexandra Rádosi, Pál Vakli, Béla Weiss, János M Réthelyi, Nóra Bunford, Zoltán Vidnyánszky
UNLABELLED: Understanding atypicalities in ADHD brain correlates is a step towards better understanding ADHD etiology. Efforts to map atypicalities at the level of brain structure have been hindered by the absence of normative reference standards. Recent publication of brain charts allows for assessment of individual variation relative to age- and sex-adjusted reference standards and thus estimation not only of case-control differences but also of intraindividual prediction. METHODS: Aim was to examine, whether brain charts can be applied in a sample of adolescents (N = 140, 38% female) to determine whether atypical brain subcortical and total volumes are associated with ADHD at-risk status and severity of parent-rated symptoms, accounting for self-rated anxiety and depression, and parent-rated oppositional defiant disorder (ODD) as well as motion...
March 14, 2024: Research on child and adolescent psychopathology
https://read.qxmd.com/read/38482853/the-protective-effect-of-vitamin-d-supplementation-as-adjunctive-therapy-to-antidepressants-on-brain-structural-and-functional-connectivity-of-patients-with-major-depressive-disorder-a-randomized-controlled-trial
#8
JOURNAL ARTICLE
Wenming Zhao, Dao-Min Zhu, Yuhao Shen, Yu Zhang, Tao Chen, Huanhuan Cai, Jiajia Zhu, Yongqiang Yu
BACKGROUND: Growing evidence points to the pivotal role of vitamin D in the pathophysiology and treatment of major depressive disorder (MDD). However, there is a paucity of longitudinal research investigating the effects of vitamin D supplementation on the brain of MDD patients. METHODS: We conducted a double-blind randomized controlled trial in 46 MDD patients, who were randomly allocated into either VD (antidepressant medication + vitamin D supplementation) or NVD (antidepressant medication + placebos) groups...
March 14, 2024: Psychological Medicine
https://read.qxmd.com/read/38479482/microstructural-alterations-of-the-hypothalamus-in-parkinson-s-disease-and-probable-rem-sleep-behavior-disorder
#9
JOURNAL ARTICLE
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xioajie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
BACKGROUND: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. OBJECTIVES: We aimed to quantify microstructural changes in hypothalamus using a novel deep learning-based tool in patients with PD and those with probable rapid-eye-movement sleep behavior disorder (pRBD). We further assessed whether these microstructural changes associated with clinical symptoms and free thyroxine (FT4) levels...
March 11, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38479347/abnormal-amplitude-of-low-frequency-fluctuations-associated-with-sleep-efficiency-in-major-depressive-disorder
#10
JOURNAL ARTICLE
Yifei Li, Wenming Zhao, Xinyu Li, Lianzi Guan, Yu Zhang, Jiakuai Yu, Jiajia Zhu, Dao-Min Zhu
BACKGROUND: Sleep disturbance is one of the most frequent somatic symptoms in major depressive disorder (MDD), but the neural mechanisms behind it are not well understood. Sleep efficiency (SE) is a good indicator of early awakening and difficulty falling asleep in MDD patients. Our study aimed to investigate the relationship between sleep efficiency and brain function in MDD patients. METHODS: We recruited 131 MDD patients from the Fourth People's Hospital in Hefei, and 71 well-matched healthy controls who were enrolled from the community...
February 21, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38479178/decoupling-the-mutual-promotion-of-inflammation-and-oxidative-stress-mitigates-cognitive-decline-and-depression-like-behavior-in-rmtbi-mice-by-promoting-myelin-renewal-and-neuronal-survival
#11
JOURNAL ARTICLE
Shenghua Lu, QianQian Ge, MengShi Yang, Yuan Zhuang, Xiaojian Xu, Fei Niu, Baiyun Liu, Runfa Tian
BACKGROUND: Repetitive mild traumatic brain injury (rmTBI) can lead to somatic, emotional, and cognitive symptoms that persist for years after the initial injury. Although the ability of various treatments to promote recovery after rmTBI has been explored, the optimal time window for early intervention after rmTBI is unclear. Previous research has shown that hydrogen-rich water (HRW) can diffuse through the blood-brain - barrier, attenuate local oxidative stress, and reduce neuronal apoptosis in patients with severe traumatic brain injury...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38478052/altered-functional-structural-coupling-may-predict-parkinson-s-patient-s-depression
#12
JOURNAL ARTICLE
Min Wang, Changlian Tan, Qin Shen, Sainan Cai, Qinru Liu, Haiyan Liao
We aimed to elucidate the neurobiological basis of depression in Parkinson's disease and identify potential imaging markers for depression in patients with Parkinson's disease. We recruited 43 normal controls (NC), 46 depressed Parkinson's disease patients (DPD) and 56 non-depressed Parkinson's disease (NDPD). All participants underwent routine T2-weighted, T2Flair, and resting-state scans on the same 3.0 T magnetic resonance imaging (MRI) scanner at our hospital. Pre-processing includes calculating surface-based Regional Homogeneity (2DReHo) and cortical thickness...
March 13, 2024: Brain Structure & Function
https://read.qxmd.com/read/38476648/brain-wide-activation-involved-in-15-ma-transcranial-alternating-current-stimulation-in-patients-with-first-episode-major-depressive-disorder
#13
JOURNAL ARTICLE
Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang
BACKGROUND: Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown. AIMS: To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain. METHODS: Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software...
2024: General Psychiatry
https://read.qxmd.com/read/38470418/reconfiguration-of-structural-and-functional-connectivity-coupling-in-patient-subgroups-with-adolescent-depression
#14
JOURNAL ARTICLE
Ming Xu, Xuemei Li, Teng Teng, Yang Huang, Mengqi Liu, Yicheng Long, Fajin Lv, Dongmei Zhi, Xiang Li, Aichen Feng, Shan Yu, Vince Calhoun, Xinyu Zhou, Jing Sui
IMPORTANCE: Adolescent major depressive disorder (MDD) is associated with serious adverse implications for brain development and higher rates of self-injury and suicide, raising concerns about its neurobiological mechanisms in clinical neuroscience. However, most previous studies regarding the brain alterations in adolescent MDD focused on single-modal images or analyzed images of different modalities separately, ignoring the potential role of aberrant interactions between brain structure and function in the psychopathology...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38469287/a-case-of-kleine-levin-syndrome-arising-during-chemotherapy-efficacy-of-oral-l-carnitine
#15
Ryuji Furihata, Daisuke Endo, Kenichi Nagaoka, Ayako Hori, Tatsuya Ito, Kazuo Chin, Toshiki Akahoshi
A woman in her 50 s with Kleine-Levin syndrome (KLS) was referred to our sleep clinic for recurrent episodes of sleep hypersomnia lasting for two to 3 days, despite attempts to remain awake. These episodes were unaccompanied by anxiety or depression, increased appetite, increased sex drive, irritability, or hallucinations, and had first appeared during chemotherapy for malignant lymphoma. Video polysomnography revealed mild obstructive sleep apnea syndrome (apnea-hypopnea index 7.9/h), but no other abnormalities...
April 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38467915/interleukin-6-is-correlated-with-amygdala-volume-and-depression-severity-in-adolescents-and-young-adults-with-first-episode-major-depressive-disorder
#16
JOURNAL ARTICLE
Yingying Chen, Xiaodi Xia, Zheyi Zhou, Meng Yuan, Yadong Peng, Ying Liu, Jinxiang Tang, Yixiao Fu
Inflammatory mechanisms may play crucial roles in the pathophysiology of major depressive disorder (MDD), and cytokine concentrations are correlated with brain alterations. Adolescents and young adults with MDD have higher recurrence and suicide rates than adults, but there has been limited research on the underlying mechanisms. In this study, we aimed to investigate the potential correlations among cytokines, depression severity, and the volumes of the amygdala, hippocampus, and nucleus accumbens in Han Chinese adolescents and young adults with first-episode MDD...
March 12, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38466739/characterizing-major-depressive-disorder-and-substance-use-disorder-using-heatmaps-and-variable-interactions-the-utility-of-operant-behavior-and-brain-structure-relationships
#17
JOURNAL ARTICLE
Nicole L Vike, Sumra Bari, Byoung Woo Kim, Aggelos K Katsaggelos, Anne J Blood, Hans C Breiter
BACKGROUND: Rates of depression and addiction have risen drastically over the past decade, but the lack of integrative techniques remains a barrier to accurate diagnoses of these mental illnesses. Changes in reward/aversion behavior and corresponding brain structures have been identified in those with major depressive disorder (MDD) and cocaine-dependence polysubstance abuse disorder (CD). Assessment of statistical interactions between computational behavior and brain structure may quantitatively segregate MDD and CD...
2024: PloS One
https://read.qxmd.com/read/38464765/neuropathological-characteristics-of-abnormal-white-matter-functional-signaling-in-adolescents-with-major-depression
#18
JOURNAL ARTICLE
Xin-Lin Huang, Ju Gao, Yong-Ming Wang, Feng Zhu, Jing Qin, Qian-Nan Yao, Xiao-Bin Zhang, Hong-Yan Sun
BACKGROUND: Major depression disorder (MDD) constitutes a significant mental health concern. Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults, with a corresponding increased risk of suicide. In studying brain dysfunction associated with MDD in adole-scents, research on brain white matter (WM) is sparse. Some researchers even mistakenly regard the signals generated by the WM as noise points. In fact, studies have shown that WM exhibits similar blood oxygen level-dependent signal fluctuations...
February 19, 2024: World Journal of Psychiatry
https://read.qxmd.com/read/38463457/severe-refractory-obsessive-compulsive-disorder-and-depression-should-we-consider-stereotactic-neurosurgery
#19
JOURNAL ARTICLE
Ludvic Zrinzo
Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as "standard of care", benefiting hundreds of thousands of patients. As with movement disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder and depression, can be framed as disorders of neural networks...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38462522/mild-encephalopathy-encephalitis-with-reversible-splenial-lesions-after-amphetamine-and-opioid-use
#20
JOURNAL ARTICLE
Youichi Yanagawa, Hiroki Nagasawa, Noriko Torizawa, Ikuto Takeuchi
A 47-year-old woman with a history of substance abuse, depression, and insomnia experienced a collapse. Upon arrival at the hospital, the patient displayed low systolic blood pressure, confusion, dehydration, and renal failure. Urine tests confirmed an amphetamine and opioid overdose. Her condition fluctuated with reduced consciousness, myoclonic movements, fever, and suspected psychogenic seizures. Brain magnetic resonance imaging revealed abnormalities in the splenium of the corpus callosum, which later resolved...
March 11, 2024: Internal Medicine
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