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https://www.readbyqxmd.com/read/28446218/increased-galectin-3-may-serve-as-a-serologic-signature-of-pre-rheumatoid-arthritis-while-markers-of-synovitis-and-cartilage-do-not-differ-between-early-undifferentiated-arthritis-subsets
#1
Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M Lindegaard, Jakob M Møller, Peter Junker
BACKGROUND: Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. METHODS: One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR)...
April 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28445740/right-brain-left-brain-in-depressive-disorders-clinical-and-theoretical-implications-of-behavioral-electrophysiological-and-neuroimaging-findings
#2
REVIEW
Gerard E Bruder, Jonathan W Stewart, Patrick J McGrath
The right and left side of the brain are asymmetric in anatomy and function. We review electrophysiological (EEG and event-related potential), behavioral (dichotic and visual perceptual asymmetry), and neuroimaging (PET, MRI, NIRS) evidence of right-left asymmetry in depressive disorders. Recent electrophysiological and fMRI studies of emotional processing have provided new evidence of altered laterality in depressive disorders. EEG alpha asymmetry and neuroimaging findings at rest and during cognitive or emotional tasks are consistent with reduced left prefrontal activity in depressed patients, which may impair downregulation of amygdala response to negative emotional information...
April 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28443058/predicting-outcome-12-months-after-mild-traumatic-brain-injury-in-patients-admitted-to-a-neurosurgery-service
#3
Torgeir Hellstrøm, Tobias Kaufmann, Nada Andelic, Helene L Soberg, Solrun Sigurdardottir, Eirik Helseth, Ole A Andreassen, Lars T Westlye
OBJECTIVE: Accurate outcome prediction models for patients with mild traumatic brain injury (MTBI) are key for prognostic assessment and clinical decision-making. Using multivariate machine learning, we tested the unique and added predictive value of (1) magnetic resonance imaging (MRI)-based brain morphometric and volumetric characterization at 4-week postinjury and (2) demographic, preinjury, injury-related, and postinjury variables on 12-month outcomes, including global functioning level, postconcussion symptoms, and mental health in patients with MTBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28442954/evaluation-of-efficacy-of-dexmedetomidine-versus-propofol-for-sedation-in-children-undergoing-magnetic-resonance-imaging
#4
Kirti Kamal, Unnati Asthana, Teena Bansal, Jagdish Dureja, Geeta Ahlawat, Saloni Kapoor
BACKGROUND: A deep level of sedation is required for magnetic resonance imaging (MRI) in children to ensure optimum image quality. The present study was conducted to evaluate the efficacy and safety of dexmedetomidine versus propofol for sedation in children undergoing MRI. MATERIALS AND METHODS: A total of sixty children aged 2-10 years, having physical status 1 or 2 according to the American Society of Anesthesiologists, undergoing MRI were included in the study...
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28434675/cadasil-as-a-useful-medical-model-and-genetic-form-of-vascular-depression
#5
Joon Hyuk Park, Bong-Hee Jeon, Jung Seok Lee, Paul A Newhouse, Warren D Taylor, Brian D Boyd, Ki Woong Kim, Moon-Doo Kim
OBJECTIVE: The main magnetic resonance imaging (MRI) findings of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are white matter hyperintensities (WMHs), lacunar infarctions, and cerebral microbleeds (CMBs). The purpose of this study was to investigate the effects of these three neuroimaging markers of CADASIL on depression to determine whether CADASIL is a useful medical model supporting the vascular depression hypothesis. METHODS: Eighty-four subjects with CADASIL, aged 34-86 years, participated in this study...
March 23, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#6
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28420004/hearing-loss-and-risk-of-mild-cognitive-impairment-and-dementia-findings-from-the-singapore-longitudinal-ageing-study
#7
Rebecca Heywood, Qi Gao, Ma Shwe Zin Nyunt, Lei Feng, Mei Sian Chong, Wee Shiong Lim, Philip Yap, Tih-Shih Lee, Keng Bee Yap, Shiou Liang Wee, Tze Pin Ng
AIM: To investigate the associations between hearing loss and prevalent and incident mild cognitive impairment (MCI), dementia and MCI or dementia (all cases). METHODS: Cross-sectional and longitudinal analyses of baseline and follow-up data were performed in a population-based cohort. The baseline sample of 2,599 adults aged ≥55 included 1,515 cognitively normal subjects who were followed up to 8 years. Hearing loss at baseline was determined by the whispered voice test, and MCI and dementia by Mini-Mental State Examination screening, Clinical Dementia Rating scale, neurocognitive tests, MRI, and panel consensus diagnosis...
April 19, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28412557/electroconvulsive-therapy-changes-the-regional-resting-state-function-measured-by-regional-homogeneity-reho-and-amplitude-of-low-frequency-fluctuations-alff-in-elderly-major-depressive-disorder-patients-an-exploratory-study
#8
Xiao-Ming Kong, Shu-Xian Xu, Yan Sun, Ke-Yong Wang, Chen Wang, Ji Zhang, Jin-Xiang Xia, Li Zhang, Bo-Jian Tan, Xin-Hui Xie
Electroconvulsive therapy (ECT) is the most effective and rapid treatment for severe major depressive disorder (MDD) in elderly patients. The mechanism of ECT is unclear, and studies on ECT in elderly MDD patients by resting-state functional magnetic resonance imaging are rare. Thirteen elderly MDD patients were scanned before and after ECT using a 3.0T MRI scanner. Regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) were processed to compare resting-state function before and after treatment...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28412090/pituitary-gland-in-bipolar-disorder-and-major-depression-evidence-from-structural-mri-studies
#9
G Delvecchio, A C Altamura, J C Soares, P Brambilla
BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28407727/randomized-clinical-trial-of-real-time-fmri-amygdala-neurofeedback-for-major-depressive-disorder-effects-on-symptoms-and-autobiographical-memory-recall
#10
Kymberly D Young, Greg J Siegle, Vadim Zotev, Raquel Phillips, Masaya Misaki, Han Yuan, Wayne C Drevets, Jerzy Bodurka
OBJECTIVE: Patients with depression show blunted amygdala hemodynamic activity to positive stimuli, including autobiographical memories. The authors examined the therapeutic efficacy of real-time functional MRI neurofeedback (rtfMRI-nf) training aimed at increasing the amygdala's hemodynamic response to positive memories in patients with depression. METHOD: In a double-blind, placebo-controlled, randomized clinical trial, unmedicated adults with depression (N=36) were randomly assigned to receive two sessions of rtfMRI-nf either from the amygdala (N=19) or from a parietal control region not involved in emotional processing (N=17)...
April 14, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28392326/preliminary-investigation-of-pain-related-changes-in-cerebral-blood-volume-in-patients-with-phantom-limb-pain
#11
Cheong Hoon Seo, Chang-Hyun Park, Myung Hun Jung, Soyeon Jang, So Young Joo, Yoonkyeong Kang, Suk Hoon Ohn
OBJECTIVE: We utilized MRI to measure CBV in patients who had undergone unilateral arm amputation following electrical injury to investigate changes in the pain network associated with phantom limb pain. DESIGN: Case-controlled exploratory MRI study of cerebral blood volume (CBV) via magnetic resonance imaging (MRI) SETTING: University hospital PARTICIPANTS: Ten patients with phantom limb pain following unilateral arm amputation and 16 healthy, age-matched participants...
April 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28388468/evaluating-the-diagnostic-utility-of-applying-a-machine-learning-algorithm-to-diffusion-tensor-mri-measures-in-individuals-with-major-depressive-disorder
#12
David M Schnyer, Peter C Clasen, Christopher Gonzalez, Christopher G Beevers
Using MRI to diagnose mental disorders has been a long-term goal. Despite this, the vast majority of prior neuroimaging work has been descriptive rather than predictive. The current study applies support vector machine (SVM) learning to MRI measures of brain white matter to classify adults with Major Depressive Disorder (MDD) and healthy controls. In a precisely matched group of individuals with MDD (n =25) and healthy controls (n =25), SVM learning accurately (74%) classified patients and controls across a brain map of white matter fractional anisotropy values (FA)...
March 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28386766/high-levels-of-neuroticism-are-associated-with-decreased-cortical-folding-of-the-dorsolateral-prefrontal-cortex
#13
C Christoph Schultz, Heide Warziniak, Kathrin Koch, Claudia Schachtzabel, Daniel Güllmar, Jürgen R Reichenbach, Ralf G Schlösser, Heinrich Sauer, Gerd Wagner
The personality trait neuroticism has been identified as a vulnerability factor for common psychiatric diseases and defining potential neuroanatomical markers for early recognition and prevention strategies is mandatory. Because both personality traits and cortical folding patterns are early imprinted and timely stable there is reason to hypothesize an association between neuroticism and cortical folding. Thus, to identify a putative linkage, we tested whether the degree of neuroticism is associated with local cortical folding in a sample of 109 healthy individuals using a surface-based MRI approach...
April 6, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28382614/migraine-with-multiple-sensory-auras
#14
Nicodemus E Oey, Yew Long Lo
Migraine auras are typically visual in nature but can manifest as disturbances in somatosensory, auditory, and olfactory senses. Reports of multiple sensory auras are rare in the literature, but their existence may offer novel insights into the pathogenesis of this highly common yet complex neurological condition. Here we report a case of multiple sensory auras involving somatosensory, auditory, and olfactory disturbances in a patient with migraine without visual manifestations. A 45-year-old woman with a 20-year history of migrainous headaches presented with complaints of rightsided facial and hand numbness and paraesthesia...
December 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/28376079/pattern-of-brain-injury-and-depressed-heart-rate-variability-in-newborns-with-hypoxic-ischemic-encephalopathy
#15
Marina Metzler, Rathinaswamy Govindan, Tareq Al-Shargabi, Gilbert Vezina, Nickie Andescavage, Yunfei Wang, Adre du Plessis, An N Massaro
BACKGROUND: Decreased heart rate variability (HRV) is a measure of autonomic dysfunction and brain injury in newborns with hypoxic ischemic encephalopathy (HIE). This study aimed to characterize the relationship between HRV and brain injury pattern by MRI in newborns with HIE undergoing therapeutic hypothermia. METHODS: HRV metrics were quantified in the time domain (αS, αL, and root mean square at short [RMSS] and long [RMSL] time scales) and frequency domain (relative low-[LF] and high-frequency [HF] power) during the time period 24-27 h of life...
April 4, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28371656/functional-network-connectivity-alterations-in-schizophrenia-and-depression
#16
Xing-Jie Wu, Ling-Li Zeng, Hui Shen, Lin Yuan, Jian Qin, Peng Zhang, Dewen Hu
There is a high degree of overlap between the symptoms of major depressive disorder (MDD) and schizophrenia, but it remains unclear whether the similar symptoms are derived from convergent alterations in functional network connectivity. In this study, we performed a group independent component analysis on resting-state functional MRI data from 20 MDD patients, 24 schizophrenia patients, and 43 matched healthy controls. The functional network connectivity analysis revealed that, compared to healthy controls, the MDD and schizophrenia patients exhibited convergent decreased positive connectivity between the left and right fronto-parietal control network and decreased negative connectivity between the left control and medial visual networks...
March 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28353539/coronary-artery-endothelial-dysfunction-is-present-in-hiv-positive-individuals-without-significant-coronary-artery-disease
#17
Micaela Iantorno, Michael Schär, Sahar Soleimanifard, Todd T Brown, Richard Moore, Patricia Barditch-Crovo, Matthias Stuber, Shenghan Lai, Gary Gerstenblith, Robert G Weiss, Allison G Hays
OBJECTIVE: HIV+ individuals experience an increased burden of coronary artery disease (CAD) not adequately accounted for by traditional CAD risk factors. Coronary endothelial function (CEF), a barometer of vascular health, is depressed early in atherosclerosis and predicts future events but has not been studied in HIV+ individuals. We tested whether CEF is impaired in HIV+ subjects without CAD as compared to an HIV- population matched for cardiac risk factors. DESIGN/METHODS: In this observational study, CEF was measured noninvasively by quantifying isometric handgrip exercise (IHE)-induced changes in coronary vasoreactivity with MRI in 18 participants with HIV but no CAD (HIV+CAD-, based on prior imaging), 36 age- and cardiac risk factor-matched healthy participants with neither HIV nor CAD (HIV-CAD-), 41 subjects with no HIV but with known CAD (HIV-CAD+) and 17 subjects with both HIV and CAD (HIV+CAD+)...
March 28, 2017: AIDS
https://www.readbyqxmd.com/read/28344075/functional-reorganization-in-obstructive-sleep-apnoea-and-insomnia-a-systematic-review-of-the-resting-state-fmri
#18
REVIEW
Habibolah Khazaie, Mattia Veronese, Khadijeh Noori, Farnoosh Emamian, Mojtaba Zarei, Keyoumars Ashkan, Guy D Leschziner, Claudia R Eickhoff, Simon B Eickhoff, Mary J Morrell, Ricardo S Osorio, Kai Spiegelhalder, Masoud Tahmasian, Ivana Rosenzweig
Functional neuroimaging techniques have accelerated progress in the study of sleep disorders. Considering the striking prevalence of these disorders in the general population, however, as well as their strong bidirectional relationship with major neuropsychiatric disorders, including major depressive disorder, their numbers are still surprisingly low. This review examines the contribution of resting state functional MRI to current understanding of two major sleep disorders, insomnia disorder and obstructive sleep apnoea...
March 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28340447/fronto-limbic-disconnection-in-depressed-patients-with-suicidal-ideation-a-resting-state-functional-connectivity-study
#19
Lian Du, Jinkun Zeng, Huan Liu, Dejian Tang, Huaqing Meng, Yongmei Li, Yixiao Fu
BACKGROUND: Suicidal ideation (SI) is highly prevalent and a known symptom of Major Depressive Disorder (MDD), but its underlying biological mechanisms are relatively unknown. Several studies linked suicidal ideation to dysfunctional brain circuits, specifically fronto-limbic connections. The purpose of this work was to investigate fronto-limbic disconnection in MDD patients with or without SI. METHODS: MDD patients with SI (SI, n=28) or without SI (NSI, n=20), identified by the Scale for Suicide Ideation and healthy controls (HCs, n=30) underwent resting-state functional MRI scanning...
February 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28336265/brain-structural-markers-and-caregiving-characteristics-as-interacting-correlates-of-caregiving-strain
#20
Stephen F Smagula, Scott Beach, Andrea L Rosso, Anne B Newman, Richard Schulz
OBJECTIVE: To evaluate the association between brain structural markers and caregiving strain among older informal caregivers. DESIGN: A secondary data analysis combining data from the Caregiver Health Effects Study (1993-1994) and the Cardiovascular Health Study MRI examination (1992-1994). SETTING: Four United States communities. PARTICIPANTS: Co-residing spousal caregivers (N = 237; mean age: 76.2 years, SD: 2...
February 21, 2017: American Journal of Geriatric Psychiatry
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