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"Cardiovascular genetic risk"

Nicola Martinelli, Oliviero Olivieri, Gong-Qing Shen, Elisabetta Trabetti, Francesca Pizzolo, Fabiana Busti, Simonetta Friso, Antonella Bassi, Lin Li, Ying Hu, Pier Franco Pignatti, Roberto Corrocher, Qing Kenneth Wang, Domenico Girelli
BACKGROUND: The R952Q variant in the low density lipoprotein receptor-related protein 8 (LRP8)/apolipoprotein E receptor 2 (ApoER2) gene has been recently associated with familial and premature myocardial infarction (MI) by means of genome-wide linkage scan/association studies. We were interested in the possible interaction of the R952Q variant with another established cardiovascular genetic risk factor belonging to the same pathway, namely apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 genotype, in modulating apolipoprotein E (ApoE) plasma levels and risk of MI...
May 13, 2009: BMC Medical Genetics
Ilan Goldenberg, Arthur J Moss, Daniel Ryan, Grzegorz Pietrasik, Wojciech Zareba, Scott McNitt, Shirley W Eberly
BACKGROUND: Previously identified atherosclerotic genetic factors have been studied mostly in case-control studies and in nonuniform ethnic populations, whereas data on the cumulative contribution of genetic factors to an earlier onset of a first myocardial infarction (MI) are limited. We hypothesized that several genetic atherosclerotic single nucleotide polymorphisms (SNPs) may exert an additive effect on the earlier occurrence of coronary atherothrombotic disease after adjustment for clinical factors...
July 2008: Annals of Noninvasive Electrocardiology
Gilles Pernod, Jean-Luc Bosson, Dela Golshayan, Claire Barro, Sandro Alloatti, Cécile Turc-Baron, Francesco Quarello, Alberto Jeantet, Beat Von Albertini, Michel Forêt, Guy Lauren, Daniel Cordonnier, Giuseppe Piccoli, Jean-Pierre Wauters et al.
BACKGROUND: Clinical and therapeutic characteristics of chronic dialysis patients vary widely at national and/or regional levels. Their increased cardiovascular (CV) mortality is not explained by traditional cardiovascular disease (CVD) risk factors only. Therefore, this study aimed to investigate and compare the characteristics of patients starting dialysis in a homogeneous Alpin region and possibly to identify new biological parameters (phenotypes or genotypes), which eould be responsible for the increased CVD seen in end-stage renal disease (ESRD) patients...
January 2004: Journal of Nephrology
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