Anna Camps-Vilaró, Mel Lina Pinsach-Abuin, Irene R Degano, Rafel Ramos, Ruth Martí-Lluch, Roberto Elosua, Isaac Subirana, Clàudia Solà-Richarte, Marta Puigmulé, Alexandra Pérez, Ingrid Vilaró, Raquel Cruz, Silvia Diz-de Almeida, Xavier Nogues, Joan R Masclans, Roberto Güerri-Fernández, Judith Marin, Helena Tizon-Marcos, Beatriz Vaquerizo, Ramon Brugada, Jaume Marrugat
Pre-existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID-19 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms of COVID-19 complications has been seldom analysed. Our aim was to test and validate the effect of candidate SNVs on COVID-19 severity. CARGENCORS (CARdiovascular GENetic risk score for Risk Stratification of patients positive for SARS-CoV-2 [COVID-19] virus) is an age- and sex-matched case-control study with 818 COVID-19 cases hospitalized with hypoxemia, and 1636 controls with COVID-19 treated at home...
February 2024: Journal of Medical Virology