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Costs cardiovascular disease

Muhammad Imtiaz Ahmad, Parag Anilkumar Chevli, Yabing Li, Elsayed Z Soliman
OBJECTIVE: Association of cardiovascular disease (CVD) with non-traditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC-MI) based on an electrocardiographic score is a simple, cost-effective and innovative way to explore this relationship. METHODS: This analysis included 6079 participants (58.3±13.1 years; 54.1% women) without CVD from NHANES III...
September 21, 2018: Clinical Cardiology
Salahdein Aburuz, Abdulkareem Al-Bekairy, Abdul-Aziz Alqahtani, Khalid Harbi, Mohammed Al Nuhait, Abdullah Khoja, Adel Sadeq, Mohammed Al Rashed
Background: One of the major risk factors for cardiovascular diseases is hyperlipidemia. The primary aim of this study was to estimate the proportion of individuals between 40-75 years old that would be eligible for statin therapy based on ACC/AHA guideline as compared to ATP-III guideline in a population of patients in Saudi Arabia. We also intended to extrapolate the results to the entire Saudi population, and estimate the cost implications of the ACC/AHA treatment guideline. Methods: This study was a retrospective, observational study involving adult patients aged between 40-75 years old...
October 2018: Journal of the Saudi Heart Association
Zanfina Ademi, Ella Zomer, Andrew Tonkin, Danny Liew
OBJECTIVE: In light of the Cardiovascular Outcomes for People using Anticoagulation Strategies (COMPASS) trial, our objective was to assess the cost-effectiveness, from the Australian healthcare perspective, of rivaroxaban in combination with aspirin versus aspirin alone for the prevention of recurrent cardiovascular disease among patients with stable atherosclerotic vascular disease. METHODS: A Markov model was developed using input data from the COMPASS trial to predict the clinical course and costs of patients over a 20-year time-horizon...
November 1, 2018: International Journal of Cardiology
Giancarlo Abis, Rebecca L Charles, Philip Eaton, Maria R Conte
The human soluble Epoxide Hydrolase (hsEH) is an enzyme involved in the hydrolysis of endogenous anti-inflammatory and cardio-protective signalling mediators known as epoxyeicosatrienoic acids (EETs). EETs' conversion into the corresponding diols by hsEH generates non-bioactive molecules, thereby the enzyme inhibition would be expected to enhance the EETs bioavailability, and their beneficial properties. Numerous inhibitors have been developed to target the enzyme, some of which are showing promising antihypertensive and anti-inflammatory properties in vivo...
September 12, 2018: Protein Expression and Purification
Sonja Kroep, Ling-Hsiang Chuang, Alexander Cohen, Pearl Gumbs, Ben van Hout, Manuel Monreal, Stefan N Willich, Anselm Gitt, Rupert Bauersachs, Giancarlo Agnelli
Venous thromboembolism (VTE) is often accompanied by co-morbidities, which complicate and confound data interpretation concerning VTE-related mortality, costs and quality of life. We aimed to assess the contribution of co-morbidities to the burden of VTE. The PREFER in VTE registry, across seven European countries, documented and followed acute VTE patients over 12 months. Patients with co-morbidities were grouped in major co-morbidity groups: cancer, cardiovascular (CV) comorbidity (other than VTE), CV risks, venous, renal, liver, respiratory, bone and joint diseases, and lower extremity paralysis...
September 14, 2018: Journal of Thrombosis and Thrombolysis
Andrew Smith, Chelsea Harris
There is considerable benefit of tight glucose control in patients with type 1 diabetes mellitus. Tight blood glucose control dramatically decreases the incidence of microvascular and macrovascular complications. Although glycemic goals should be individualized, most nonpregnant adults should strive for an A1C level less than 7%. Greater frequency of glucose monitoring and continuous glucose monitoring are both associated with lower A1C levels. The choice to monitor glucose levels via multiple daily capillary blood samples or continuous glucose monitoring is based on cost and patient preference...
August 1, 2018: American Family Physician
Ladislav Batalik, Filip Dosbaba, Martin Hartman, Katerina Batalikova, Jindrich Spinar
BACKGROUND: Cardiovascular diseases remain the most common causes of death in the world. Instructions for secondary prevention recommend multifaceted approach in cardiovascular diseases risk management. Center-based physical exercise training is considered as an important integral part of cardiac rehabilitation (CR). Despite all recognized benefits CR brings, active interest of patients remains low in many countries, including the Czech Republic. That is why there is a need to focus on more effective patients' participation in CR with respect to their preferences and needs...
September 2018: Medicine (Baltimore)
Matthew D Ritchey, Hilary K Wall, Pamela L Owens, Janet S Wright
INTRODUCTION: Despite its preventability, cardiovascular disease remains a leading cause of morbidity, mortality, and health care costs in the United States. This study describes the burden, in 2016, of nonfatal and fatal cardiovascular events targeted for prevention by Million Hearts 2022, a national initiative working to prevent one million cardiovascular events during 2017-2021. METHODS: Emergency department (ED) visits and hospitalizations were identified using Healthcare Cost and Utilization Project databases, and deaths were identified using National Vital Statistics System data...
September 7, 2018: MMWR. Morbidity and Mortality Weekly Report
Alex S Harrison, Patrick Doherty
Aims Cardiac rehabilitation is one of the most cost-effective interventions for patients with cardiovascular disease. Worldwide supervised group-based cardiac rehabilitation is the dominant mode of delivery followed by facilitated self-managed (FSM), which is emerging as part of a cardiac rehabilitation menu. Modern research evidence, using trials and well-resourced interventions, suggests FSM is comparable to supervised rehabilitation in its outcomes for patients; however, this is yet to be established using routine clinical practice data...
September 6, 2018: European Journal of Preventive Cardiology
Elisabeth Lauritzen, Asbjørn Kørvel-Hanquist, Preben Homøe
INTRODUCTION: Obstructive sleep apnoea (OSA) is an increasing health problem related to cardiovascular disease, poor quality of life, daytime sleepiness and un-restorative sleep with an estimated prevalence up to 20% in the adult population. Approximately 82% of men and 93% of women with moderate to severe OSA remain undiagnosed. Relevant, fast, accurate and cost-effective screening methods are essential. The aim of this study was to translate and validate the Danish version of the Berlin Questionnaire (BQ), and to investigate if the questionnaire can be used for screening of OSA in a Danish population...
September 2018: Danish Medical Journal
Veronica Bonderski, Daniel G Morrow, Jessie Chin, Michael D Murray
Heart failure is a chronic disease requiring careful attention to self-care. Patients must follow instructions for diet and medication use to prevent or delay a decline in functional status, quality of life, and expensive care. However, there is considerable heterogeneity in heart failure patients' knowledge of important care routines, their cognition, and their health literacy, which predict the ability to implement self-care. Our interdisciplinary team of cognitive scientists with health literacy expertise, pharmacists, and physicians spent 18 years designing and testing protocols and materials to assist ambulatory heart failure patients with their care...
September 6, 2018: Drugs & Aging
Ruth B Gutiérrez-Perez, Nidia M Zuluaga-Londoño, Felipe A Gallego-López
OBJECTIVES : To determine the cardiovascular risk factors in a coffee population of the department of Caldas. MATERIALS AND METHODS : A Cross-sectional study was carried out in 2015 to 964 coffee growers affiliated to la Cooperativa de Caficultores de Manizales in six sites located in the center and east of the department. After the survey, anthropometric measures and biochemical tests were performed. The results were analyzed in the Statistical Package for the Social Sciences (SPSS)...
November 2017: Revista de Salud Pública
Augusto Martins Lima, Maiia E Bragina, Olivier Burri, Julien Bortoli Chapalay, Fabiana P Costa-Fraga, Marc Chambon, Rodrigo A Fraga-Silva, Nikolaos Stergiopulos
Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughput screening (HTS) format. Currently, all assays capable of assessing platelet function are either expensive, complex, or not validated, which makes them unsuitable for drug discovery. Here, we propose a simple, low-cost, and high-throughput-compatible platelet function assay, validated for the 384-well plate...
September 5, 2018: Platelets
Antonio Cittadini, Roberta D'Assante
Heart failure (HF) is a disease characterized by increasing prevalence, huge direct and indirect costs, and an ominous prognosis, worse than many cancers. At the beginning of the 90s, growth hormone (GH) was proposed as potential adjunctive therapy in HF mostly due to its growth-promoting, vasodilating, and anti-apoptotic actions. However, although several uncontrolled clinical studies showed that GH therapy improved several cardiovascular parameters, two robust trials failed to confirm these findings. Dwelling upon potential explanations for such apparent discrepancy led to the hypothesis that HF patients exhibit an inhomogeneous basal activity of the GH/insulin-like growth factor 1 (IGF-1) axis, ranging from GH/IGF-1 deficiency to GH resistance...
September 5, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Linghua Fu, Wengen Zhu, Lin Huang, Jinzhu Hu, Jianyong Ma, Gregory Y H Lip, Kui Hong
BACKGROUND: There are conflicting published data on non-vitamin K antagonist oral anticoagulants (NOACs), with varying evidence of benefit or harm in acute coronary syndrome (ACS) and non-ACS cohorts. To explore the efficacy and safety of NOAC use in patients with ischemic heart disease (IHD), we conducted a meta-analysis of phase III randomized controlled trials (RCTs). METHODS: We systematically searched the Cochrane Library, PubMed, and Embase databases. A random-effect model was selected to pool the effect measurement estimates (hazard ratios [HRs] and 95% confidence intervals [CIs])...
September 4, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Fernando Estévez-López, Jesus Castro-Marrero, Xia Wang, Inger Johanne Bakken, Andrejs Ivanovs, Luis Nacul, Nuno Sepúlveda, Elin B Strand, Derek Pheby, Jose Alegre, Carmen Scheibenbogen, Evelina Shikova, Lorenzo Lorusso, Enrica Capelli, Slobodan Sekulic, Eliana Lacerda, Modra Murovska
INTRODUCTION: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease involving central nervous system and immune system disorders, as well as cardiovascular abnormalities. ME/CFS is characterised by severe chronic fatigue lasting for at least 6 months, including clinical symptoms such as tender cervical or axillary lymph nodes, muscle pain, joint pain without swelling or redness, post-exertional malaise for more than 24 hours and unrefreshing sleep. Studies on the epidemiology of ME/CFS in Europe only include single countries and, therefore, the prevalence and incidence of ME/CFS in Europe (as a whole) is unknown...
September 4, 2018: BMJ Open
Junichi Ishigami, Kunihiro Matsushita
Infectious disease is recognized as an important complication among patients with end-stage renal disease, contributing to excess morbidity and health care costs. However, recent epidemiological studies have revealed that even mild to moderate stages of chronic kidney disease (CKD) substantially increase risk of infection. Regarding underlying mechanisms, evidence suggests various aspects of altered immune response in patients with CKD including impaired function of T cells, B cells and neutrophil. Multiple conditions surrounding CKD, such as older age, diabetes, and cardiovascular disease are important contributors in the increased susceptibility to infection in this population...
September 3, 2018: Clinical and Experimental Nephrology
Kyoung Im Cho, Ichiro Sakuma, Il Suk Sohn, Sang-Ho Jo, Kwang Kon Koh
Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have identified important regulatory roles for immunological and inflammatory responses, including oxidized lipids, various cytokines, and biomineralization. Recent clinical and experimental studies in atherosclerosis and osteoporosis have demonstrated that oxidative stress and oxidized lipids decrease bone formation in the skeletal system while they increase bone formation in the cardiovascular system...
August 25, 2018: Atherosclerosis
Delphine De Smedt, Lieven Annemans, Guy De Backer, Kornelia Kotseva, Lars Rydèn, David Wood, Philippe Amouyel, Jan Bruthans, Renata Cifkova, Johan De Sutter, Marina Dolzhenko, Andrejs Erglis, Nina Gotcheva, Viveca Gyberg, Aleksandras Laucevicius, Dragan Lovic, Rafael Oganov, Andrzej Pajak, Nana Pogosova, Željko Reiner, Martin Stagmo, Dirk De Bacquer
BACKGROUND: This study aims to assess the cost-effectiveness of optimized guideline adherence in patients with a history of coronary heart disease. METHODS: An individual-based decision tree model was developed using the SMART risk score tool which estimates the 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease (CVD). Analyses were based on the EUROASPIRE IV survey. Outcomes were expressed as an incremental cost-effectiveness ratio (ICER)...
June 28, 2018: International Journal of Cardiology
Jessica L Harding, Meda E Pavkov, Dianna J Magliano, Jonathan E Shaw, Edward W Gregg
In recent decades, large increases in diabetes prevalence have been demonstrated in virtually all regions of the world. The increase in the number of people with diabetes or with a longer duration of diabetes is likely to alter the disease profile in many populations around the globe, particularly due to a higher incidence of diabetes-specific complications, such as kidney failure and peripheral arterial disease. The epidemiology of other conditions frequently associated with diabetes, including infections and cardiovascular disease, may also change, with direct effects on quality of life, demands on health services and economic costs...
August 31, 2018: Diabetologia
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