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https://www.readbyqxmd.com/read/30419449/assessing-the-burden-of-type-2-diabetes-in-china-considering-the-current-status-quo-management-and-implications-of-improved-management-using-a-modeling-approach
#1
Volker Foos, Ke Wang, Phil McEwan, Yanlei Zhang, Ping Xin, Xiaohua Jiang, Shuli Qu, Tengbin Xiong, Raf De Moor, Mafalda Ramos, Mark Lamotte, Linong Ji
BACKGROUND: Recent estimates from the International Diabetes Federation Diabetes Atlas have quantified the total annual expenditure for diabetes in China to be between 354 and 611 billion Chinese yuan (¥) (2015). OBJECTIVES: To use a modeling approach to assess the current and possible future diabetes burden in China on the basis of the current standard of type 2 diabetes (T2D) management (status quo [SQ]) and a series of hypothetical improved management strategies...
November 9, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/30412596/cost-effectiveness-evaluation-of-the-45-49-year-old-health-check-versus-usual-care-in-australian-general-practice-a-modelling-study
#2
Si Si, John Moss, Jonathan Karnon, Nigel Stocks
OBJECTIVES: To assess the potential cost-effectiveness of the 45-49 year old health check versus usual care in Australian general practice using secondary data sources. METHOD: Risk factor profiles were generated for a hypothetical Australian cohort using data from the National Health Survey. Intervention effects were modelled based on a meta-analysis on risk factor changes in the 5 years after a health check. The Framingham Risk Equation was applied to estimate the 5-year cardiovascular disease (CVD) incidence in the health check and usual care group respectively...
2018: PloS One
https://www.readbyqxmd.com/read/30412008/pharmacoeconomic-evaluation-of-sodium-glucose-transporter-2-sglt2-inhibitors-for-the-treatment-of-type-2-diabetes
#3
Wedad Rahman, Paul Joseph Solinsky, Kashif M Munir, Elizabeth M Lamos
Clinicians have many safe and effective options for the treatment of type 2 diabetes that can improve glycemic control and effect other cardio-metabolic parameters. Sodium-glucose transporter-2 inhibitors (SGLT-2) are the most recent class of therapies, have a novel mechanism of action, and provide good glycemic efficacy and a favorable cardiovascular risk profile. Cost-effectiveness data can play an important role in assessing the benefits of this class of therapy in anti-diabetes treatment regimens. Areas covered: This review summarizes all the available evidence regarding the cost-effectiveness of SGLT-2 inhibitors...
November 9, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30410312/integrating-factors-associated-with-hypertensive-patients-self-management-using-structural-equation-modeling-a-cross-sectional-study-in-guangdong-china
#4
Weiwei Ding, Tong Li, Qiying Su, Maohua Yuan, Aihua Lin
Purpose: Hypertension is considered a major public health issue worldwide because of its high frequency and concomitant risk of cardiovascular disease (CVD). Chronic-disease self-management has been proven to be cost-effective, but influencing factors and pathways remain complex and unclear. The purpose of this study was to integrate factors associated with hypertension self-management to provide a theoretical reference for community hypertension management. Methods: A total of 268 community-dwelling hypertensive patients were enrolled in a cross-sectional study conducted from July to September in 2017...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30404981/repurposing-of-approved-cardiovascular-drugs-against-ischemic-cerebrovascular-disease-by-disease-disease-associated-network-assisted-prediction
#5
Qin-Qin Zhao, Xiang Li, Li-Ping Luo, Yi Qian, Yi-Lin Liu, Hang-Ting Wu
Stroke is one of the leading causes of death and disability globally, while intravenous thrombolysis with recombinant tissue plasminogen activator remains the only FDA-approved therapy for ischemic stroke. The attempts to develop new treatments for acute ischemic stroke meet costly and spectacularly disappointing results, which requires both long time and high costs, whereas repurposing of safe existing drugs to new indications provides a cost-effective and not time-consuming alternative. Vascular protection is a promising strategy for improving stroke outcome, as vascular function is critical to both cardiovascular diseases (CVD) and ischemic cerebrovascular disease (ICD)...
November 8, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30402668/integrating-active-learning-and-transfer-learning-for-carotid-intima-media-thickness-video-interpretation
#6
Zongwei Zhou, Jae Shin, Ruibin Feng, R Todd Hurst, Christopher B Kendall, Jianming Liang
Cardiovascular disease (CVD) is the number one killer in the USA, yet it is largely preventable (World Health Organization 2011). To prevent CVD, carotid intima-media thickness (CIMT) imaging, a noninvasive ultrasonography method, has proven to be clinically valuable in identifying at-risk persons before adverse events. Researchers are developing systems to automate CIMT video interpretation based on deep learning, but such efforts are impeded by the lack of large annotated CIMT video datasets. CIMT video annotation is not only tedious, laborious, and time consuming, but also demanding of costly, specialty-oriented knowledge and skills, which are not easily accessible...
November 6, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/30402533/cardiologist-and-diabetologist-crosstalk-in-the-era-of-cardiovascular-outcome-trials-of-novel-glucose-lowering-drugs
#7
REVIEW
Francesco Maranta, Lorenzo Cianfanelli, Maria Regoni, Domenico Cianflone
The prevalence of type 2 diabetes continues to increase and cardiovascular (CV) diseases remain the leading cause of death in diabetic patients. Diabetologists and Cardiologists have to work together in order to provide the best management to these patients. After years of disappointing studies showing no reduction of CV events with strict glycaemic control, some of the novel glucose-lowering drugs (GLDs) seem to offer a new approach to tackle the problem, since the CV outcome trials (CVOTs-D) of liraglutide, semaglutide, empagliflozin and canagliflozin have demonstrated not only their CV safety but also their efficacy in the reduction of CV morbidity and mortality...
December 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/30398481/sodium-zirconium-cyclosilicate-a-new-potassium-binder-for-the-treatment-of-hyperkalemia
#8
A Cases, J L Gorriz
Hyperkalemia is one of the most common electrolyte disturbances, especially among some groups of patients, such as in those with chronic kidney disease, diabetes or heart failure. Hyperkalemia has been associated with increased risks of mortality, arrhythmias, hospitalization and costs, as well as the need to down titrate/discontinue renin-angiotensin-aldosterone system inhibitors (RAASIs), despite their well-known cardiovascular and nephroprotective benefits. Current potassium binders have limitations (slow onset of action, limited selectivity for potassium binding, risk of drug interactions or gastrointestinal intolerance)...
October 2018: Drugs of Today
https://www.readbyqxmd.com/read/30396516/colchicine-in-stable-coronary-artery-disease
#9
REVIEW
Aernoud T L Fiolet, Stefan M Nidorf, Arend Mosterd, Jan H Cornel
PURPOSE: Disease management of stable coronary artery disease consists of controlling hemostasis and lipid regulation. No treatment strategies preventing plaque erosion or rupture are yet available. Cholesterol crystal-induced inflammation leading to plaque destabilization is believed to be an important factor contributing to plaque instability and might well be amenable to treatment with anti-inflammatory drugs. Colchicine has anti-inflammatory properties with the potential to address both the direct and indirect inflammatory mechanisms in the plaque...
November 2, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/30396378/cyp2c19-polymorphism-in-relation-to-the-pharmacotherapy-optimization-of-commonly-used-drugs
#10
B Sienkiewicz-Oleszkiewicz, A Wiela-Hojeńska
Purpose : The CYP2C19 isoenzyme plays an important role in the efficacy and safe use of many drugs. The aim of this review is to demonstrate how CYP2C19 mutations influence everyday patient treatment, leading to adverse drug reactions or therapy failure in many common diseases. Methods : A PubMed literature search was performed on clinical publications evaluating the impact of CYP2C19 on pharmacotherapy outcome. Main fields of medicine with strong outcome dependency on the CYP2C19 genotype were selected. We also focused on clinical recommendations for the use of drugs referring to CYP2C19 polymorphism...
November 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/30389756/general-practitioners-perspectives-on-the-prevention-of-cardiovascular-disease-systematic-review-and-thematic-synthesis-of-qualitative-studies
#11
Irene Ju, Emily Banks, Bianca Calabria, Angela Ju, Jason Agostino, Rosemary J Korda, Tim Usherwood, Karine Manera, Camilla S Hanson, Jonathan C Craig, Allison Tong
OBJECTIVE: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally, and prevention of CVD is a public health priority. This paper aims to describe the perspectives of general practitioners (GPs) on the prevention of CVD across different contexts. DESIGN: Systematic review and thematic synthesis of qualitative studies using the Enhancing Transparency of Reporting the Synthesis of Qualitative research (ENTREQ) framework. DATA SOURCES: MEDLINE, Embase, PsycINFO and CINAHL from database inception to April 2018...
November 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/30386701/recent-advances-and-challenges-on-application-of-tissue-engineering-for-treatment-of-congenital-heart-disease
#12
Antonia Mantakaki, Adegbenro Omotuyi John Fakoya, Fatemeh Sharifpanah
Congenital heart disease (CHD) affects a considerable number of children and adults worldwide. This implicates not only developmental disorders, high mortality, and reduced quality of life but also, high costs for the healthcare systems. CHD refers to a variety of heart and vascular malformations which could be very challenging to reconstruct the malformed region surgically, especially when the patient is an infant or a child. Advanced technology and research have offered a better mechanistic insight on the impact of CHD in the heart and vascular system of infants, children, and adults and identified potential therapeutic solutions...
2018: PeerJ
https://www.readbyqxmd.com/read/30382178/accuracy-of-blood-pressure-monitoring-devices-a-critical-need-for-improvement-that-could-resolve-discrepancy-in-hypertension-guidelines
#13
James E Sharman, Thomas H Marwick
Hypertension is the most significant modifiable risk factor for cardiovascular disease and contributes to the highest global burden of disease. Blood pressure (BP) measurement is among the most important of all medical tests, and it is critical for BP monitoring devices to be accurate. Comprehensive new evidence from meta-analyses clearly shows that many BP monitoring devices (including oscillometric machines and "gold standard" mercury auscultation) do not accurately represent the BP within the arteries at the upper arm (brachial) or central aorta...
October 31, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/30376360/thy1-cd90-expression-is-regulated-by-dna-methylation-during-adipogenesis
#14
E'Lissa M Flores, Collynn F Woeller, Megan L Falsetta, Martha Susiarjo, Richard P Phipps
The obesity epidemic is developing into the most costly health problem facing the world. Obesity, characterized by excessive adipogenesis and enlarged adipocytes, promotes morbidities, such as diabetes, cardiovascular disease, and cancer. Regulation of adipogenesis is critical to our understanding of how fat cell formation causes obesity and associated health problems. Thy1 (also called CD90), a widely used stem cell marker, blocks adipogenesis and reduces lipid accumulation. Thy1-knockout mice are prone to diet-induced obesity...
October 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30373089/the-strong-heart-water-study-informing-and-designing-a-multi-level-intervention-to-reduce-arsenic-exposure-among-private-well-users-in-great-plains-indian-nations
#15
Elizabeth D Thomas, Joel Gittelsohn, Joseph Yracheta, Martha Powers, Marcia O'Leary, David E Harvey, Reno Red Cloud, Lyle G Best, Annabelle Black Bear, Ana Navas-Acien, Christine Marie George
Elevated arsenic exposure from drinking water is associated with an increased risk of cardiovascular disease, diabetes, kidney disease, and skin, lung, and bladder cancer. Arsenic contamination in groundwater supplies disproportionately affects rural populations using private wells. Arsenic mitigation programs for American Indian communities are limited. There is an urgent need for targeted approaches to reduce arsenic exposure for at-risk communities using private wells. Formative research was conducted to inform and design a community-based arsenic mitigation intervention for Lakota and Dakota Nations in the Great Plains Area of the United States, where, in some communities, one-quarter of private wells are estimated to have elevated arsenic...
February 10, 2019: Science of the Total Environment
https://www.readbyqxmd.com/read/30371242/high-triglycerides-are-associated-with-increased-cardiovascular-events-medical-costs-and-resource-use-a-real-world-administrative-claims-analysis-of-statin-treated-patients-with-high-residual-cardiovascular-risk
#16
Peter P Toth, Craig Granowitz, Michael Hull, Djibril Liassou, Amy Anderson, Sephy Philip
Background The American Heart Association recognizes high triglycerides as a cardiovascular risk factor. Methods and Results This retrospective observational administrative claims analysis (Optum Research Database) included statin-treated patients ≥45 years old with diabetes mellitus and/or atherosclerotic cardiovascular disease, triglycerides 2.26 to 5.64 mmol/L, and a propensity-matched comparator cohort with triglycerides <1.69 mmol/L and high-density lipoprotein cholesterol >1.04 mmol/L. In the high-triglycerides cohort versus comparators (both n=10 990, 49% women), mean age was 61...
August 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30368802/predictors-of-cardiovascular-outcome-and-re-hospitalization-in-elderly-patients-with-heart-failure
#17
REVIEW
Gian Marco Rosa, Riccardo Scagliola, Paola Ghione, Alberto Valbusa, Claudio Brunelli, Federico Carbone, Fabrizio Montecucco, Fiammetta Monacelli
BACKGROUND: Heart failure (HF) is a major public health problem and represents the only cardiac disease continuing to increase in prevalence, in particular among elderly patients. The frequent re-hospitalizations have a negative impact on quality of life of patients with HF, constituting a substantial cost for patients and the health system. The aim of this review is to look into biochemical, echocardiographic and socio-economical parameters as predictors of clinical outcomes and re-hospitalizations...
October 28, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30368693/preventing-lethal-prostate-cancer-with-diet-supplements-and-rx-heart-healthy-continues-to-be-prostate-healthy-and-first-do-no-harm-part-i
#18
REVIEW
Mark A Moyad
PURPOSE OF REVIEW: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention. RECENT FINDINGS: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, but heart unhealthy is prostate unhealthy...
October 27, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/30365662/hypertension-bearers-with-high-risk-big-risk-of-cardiovascular-diseases-and-socioeconomic-and-health-indicators
#19
Simone de Melo Costa, Cássio de Almeida Lima, André Luiz Cândido Sarmento Drumond Nobre, Davi de Melo Alvarenga Vieira, André Luiz Ramos Leal
OBJECTIVE: To correlate the number of hypertensive patients with high and very high risk for cardiovascular diseases with socioeconomic and health indicators. METHODS: An ecological study carried out from the National Registry of Hypertension and Diabetes (SisHiperDia). The variable "hypertensive patients with high and very high risk" was correlated with the Human Development Index, health care costs and services, average household income per capita, per capita municipal income, number of hospital admissions in SUS, number of medical consultations in the SUS and specific mortality due to diseases of the circulatory system, considering the 27 federative units of Brazil...
July 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30364059/beyond-conventional-secondary-prevention-in-coronary-artery-disease-what-to-choose-in-the-era-of-cantos-compass-fourier-odyssey-and-pegasus-timi-54-a-review-on-contemporary-literature
#20
REVIEW
Daniel Kalbacher, Christoph Waldeyer, Stefan Blankenberg, Dirk Westermann
Patients with established cardiovascular (CV) disease remain at dramatic residual risk for subsequent events, despite growing evidence in secondary prevention and wider dissemination of intensive treatment. This review focuses on new options in secondary risk prevention as presented by these five major randomized controlled trials (RCT): PEGASUS-TIMI 54, COMPASS, FOURIER, ODYSSEY and CANTOS. Three main therapeutic targets are addressed: residual cholesterol, residual inflammatory and residual thrombotic risk...
August 2018: Annals of Translational Medicine
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